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https://www.readbyqxmd.com/read/29924878/chiari-i-malformation-and-basilar-invagination-in-fibrous-dysplasia-prevalence-mechanisms-and-clinical-implications
#1
Kristen S Pan, John D Heiss, Sydney M Brown, Michael T Collins, Alison M Boyce
Fibrous dysplasia (FD) is a mosaic disorder of benign fibro-osseous lesions, which may be associated with extraskeletal features as part of McCune-Albright syndrome (MAS). Cranial base abnormalities, including Chiari I malformation (CM1), in which the cerebellum extends below the foramen magnum, and secondary basilar invagination (BI), in which the odontoid prolapses into the posterior cranial fossa, are potentially serious complications of metabolic bone disorders. The purpose of this study was to determine the prevalence, natural history, and risk factors for CM1 and BI in patients with FD/MAS, and to determine mechanisms of cranial base deformities...
June 20, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29923952/a-cadaver-study-investigating-structures-encountered-by-the-needle-during-a-retroclavicular-approach-to-infraclavicular-brachial-plexus-block
#2
Sushil F Sancheti, Vishal Uppal, Robert Sandeski, M Kwesi Kwofie, Jennifer J Szerb
BACKGROUND AND OBJECTIVES: Retroclavicular block is designed to overcome the negative aspects of the commonly utilized ultrasound-guided parasagittal approach to the infraclavicular block. However, this approach necessitates the needle traversing an area posterior to the clavicle inaccessible to ultrasound wave conduction. This study sought to document the structures vulnerable to needle injury during a retroclavicular block. METHODS: A Tuohy needle was inserted using a retroclavicular approach to the infraclavicular block in 3 lightly embalmed cadavers followed by a catheter insertion 4 cm beyond the needle tip...
June 19, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29923837/geometric-and-dosimetric-comparison-of-four-intrafraction-motion-adaptation-strategies-for-stereotactic-liver-radiotherapy
#3
Saber Nankali, Esben S Worm, Rune Hansen, Britta Weber, Morten Høyer, Alireza Zirak, Per Rugaard Poulsen
The accuracy of stereotactic body radiotherapy (SBRT) in the liver is limited by tumor motion. Selection of the most suitable motion mitigation strategy requires good understanding of the geometric and dosimetric consequences. This study compares the geometric and dosimetric accuracy of actually delivered respiratory gated SBRT treatments for 15 patients with liver tumors with three simulated alternative motion adaptation strategies. The simulated alternatives are MLC tracking, baseline shift adaptation by inter-field couch corrections and no intrafraction motion adaptation...
June 20, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29923043/current-treatment-of-endolymphatic-sac-tumor-of-the-temporal-bone
#4
REVIEW
William M Mendenhall, Carlos Suárez, Alena Skálová, Primož Strojan, Asterios Triantafyllou, Kenneth O Devaney, Michelle D Williams, Alessandra Rinaldo, Alfio Ferlito
An endolymphatic sac tumor (ELST) is a rare, indolent but locally aggressive tumor arising in the posterior petrous ridge. Patients present with sensorineural hearing loss and tinnitus. As the tumor progresses, patients may experience vertigo, ataxia, facial nerve paresis, pain and otorrhea. Most patients present in their 4th or 5th decade with a wide age range. Patients with von Hippel-Lindau disease have an increased likelihood of developing ELST. Histologically, ELST is a low-grade adenocarcinoma. As it progresses, it destroys bone and extends into adjacent tissues...
June 19, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29922837/intrinsic-laryngeal-muscle-response-to-a-public-speech-preparation-stressor
#5
Leah B Helou, Clark A Rosen, Wei Wang, Katherine Verdolini Abbott
Purpose: Research suggests that abnormal levels of intrinsic laryngeal muscle (ILM) contraction is a potential causal factor in stress-induced voice disorders. This study seeks to characterize the ILM stress response in a cohort of vocally healthy women. Method: The authors used an unblinded, nonrandomized, repeated-measures design. Forty vocally healthy female adults were subjected to a stressful speech preparation task. Measurements of heart rate, blood pressure, trapezius muscle (positive control) activation, and tibialis muscle (negative control) activation were obtained from 37 participants before and during stressor exposure, in a nonvoice and nonspeaking task paradigm, to confirm physiological stress response compared to baseline...
June 19, 2018: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29922605/efficacy-of-srm-iv-vestibular-function-diagnosis-and-treatment-system-in-treating-benign-paroxysmal-positional-vertigo
#6
Nuan Wang, Hao Zhou, Hongli Huang, Deqin Geng, Xiuhua Yang, Chunyu Yu, Di Shi
Background: We determined the diagnostic and therapeutic effects of SRM-IV vestibular function diagnosis and treatment system on benign paroxysmal positional vertigo (BPPV). Methods: Overall, 120 patients with BPPV diagnosed in the outpatient and in-patient departments of the Vertigo Treatment Center of the First People's Hospital of Xuzhou from January 2013 to December 2015 were selected for this study. They were randomly divided into three groups. Automatic repositioning procedure was conducted for 40 patients in the equipment repositioning group by SRM-IV vestibular function diagnosis and treatment system, conventional manual repositioning procedure was used for 40 patients in the manual repositioning group, and combination of treatment drugs (alprostadil and safflower injection) with acclimatization training was adopted in 40 patients in the drug therapy group...
May 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29922373/balance-and-lower-limb-muscle-activation-between-in-line-and-traditional-lunge-exercises
#7
Paulo H Marchetti, Mauro A Guiselini, Josinaldo J da Silva, Raymond Tucker, David G Behm, Lee E Brown
In-line and traditional lunge exercises present differences in technique as lower limb positioning (anterioposterior), and medio-lateral (ML) balance may differentially affect primary and stabilizer muscles. The purposes of this study were to examine ML balance and muscle activation in anterior and posterior leg positions between in-line and traditional lunge exercises. Fifteen young, healthy, resistance-trained men (25 ± 5 years) performed 2 different lunge exercises (in-line and traditional) at their 10 repetition maximum in a randomized, counterbalanced fashion...
June 2018: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29921835/one-dimensional-mathematical-model-based-automated-assessment-of-fractional-flow-reserve-in-a-patient-with-silent-myocardial-ischemia
#8
Daria Gognieva, Timur Gamilov, Roman Pryamonosov, Vladimir Betelin, Sergey K Ternovoy, Natalya S Serova, Sergej Abugov, Dmitry Shchekochikhin, Yulia Mitina, Houssem El-Manaa, Philippe Kopylov
BACKGROUND Noninvasive assessment of the fractional flow reserve (FFR) in patients with coronary artery disease plays an important role in determining the need for revascularization. It is particularly relevant for patients with a borderline stenoses and painless myocardial ischemia. Our article describes the first clinical experience in the Russian Federation of using an automated method of noninvasive assessment of the fractional flow reserve (FFRct) with a one-dimensional (1-D) mathematical model in a patient with painless myocardial ischemia...
June 20, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29921074/-clinical-analysis-of-idiopathic-sudden-sensorineural-hearing-loss-with-vertigo-and-without-vertigo
#9
F Zhou, M C Zhu, M Wang, H T Wang, Y L Jiao, L F Huang, Z J Liang
Objective: To explore the clinical characteristics and treatments of patients with idiopathic sudden sensorineural hearing loss(ISSHL) with or without vertigo. Method: One hundred and twenty ISSHL cases were divided into vertigo group ( n =36) , without vertigo group ( n =84) , and with benign paroxysmal positional vertigo group ( n =15). All patients were in regular treatment. Besides, according to the types of BPPV, patients do the Epley maneuver or Barbecue roll maneuver. We summarized the result and treatment of the patients...
June 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29921055/-features-of-vestibular-evoked-myogenic-potential-in-patients-with-residual-dizziness-after-canalith-repositioning-procedures-for-benign-paroxysmal-positional-vertigo
#10
Y S Tian, Y Zhang, R Ma, P Liu
Objective: To ananlyze the characteristics of the vestibular evoked myogenic action potential of patients with residual dizziness after successful canalith repositioning procedures(CRP)for idiopathic benign paroxysmal positional vertigo(IBPPV). Method: Ninety-seven consecutive patients with IBPPV of the unilateral posterior semicircular canal and health controls were initially enrolled. The patients received 500 Hz tone burst evoked ocular vestibular evoked myogenic potentials(oVEMP) and cervical vestibular evoked myogenic potentials (cVEMP)...
June 5, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29921050/-clinical-features-of-recurrences-in-benign-paroxysmal-positional-vertigo
#11
X X Li, Y K Ou, X W Tang, L Chen, P Liu, Q H Huang, Y Q Zheng
Objective: To study the clinical features of patients with recurrent benign paroxysmal positional vertigo (BPPV) and to analyze potential related factors of recurrences. Method: Eighty patients who suffered recurrent BPPV were enrolled in this study. Patients were divided into three groups: young group (21 cases), middle-aged group (25 cases) and old-aged group (34 cases). Theclinical data including age, gender, pathological pattern and canal type of BPPV were collected. We further analyzed the efficacy of repositioning treatment for recurrent BPPV...
June 5, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29921048/-diagnosis-and-treatment-of-canal-conversion-during-canalith-repositioning-procedure-for-benign-paroxysmal-positional-vertigo
#12
H M Huang, Y Huang, Y Cui, R M Ge, M Fu
Objective: To investigate the diagnosis and treatment of canal conversion during canalith repositioning procedure for benign paroxysmal positional vertigo. Method: The clinic features, nystagmus characteristics, diagnosis and treatment of the patients with benign paroxysmal positional vertigo who suffered from canal conversion during canalith repositioning procedure were analyzed retrospectively.All patients'positioning test and canalith repositioning procedure were done with the aid of videonystagmography...
June 5, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29920914/robot-assisted-percutaneous-screw-placement-combined-with-pelvic-internal-fixator-for-minimally-invasive-treatment-of-unstable-pelvic-ring-fractures
#13
Hua-Shui Liu, Sheng-Jun Duan, Shi-Dong Liu, Feng-Shuang Jia, Li-Ming Zhu, Min-Cen Liu
PURPOSE: The purpose of this study was to investigate the safety and efficacy of the combination of robot-assisted percutaneous screw placement and pelvic internal fixator (INFIX) for minimally invasive treatment of unstable anterior and posterior pelvic ring injuries. METHODS: From September 2016 to June 2017, twenty-four patients with unstable anterior and posterior pelvic ring injuries were treated with TiRobot-assisted percutaneous sacroiliac cannulated screw fixation on the posterior pelvic ring combined with robot-assisted pedicle screw placement in the anterior inferior iliac spine along with INFIX on the anterior pelvic ring...
June 19, 2018: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/29915974/managing-a-positive-air-leak-test-during-a-gastrojejunostomy-revision
#14
Dvir Froylich, Matthew Davis, Gautam Sharma, Tammy Fouse, Philip Schauer, Stacy Brethauer
BACKGROUND: Gastrojejunostomy revision after gastric bypass surgery is a challenging procedure that requires advanced skills. The air-leak test was performed to identify gastrojejunostomy leaks. Omental patch seal technique is a well-known treatment of perforated gastrojejunostomy ulcers (Surg Obes Relat Dis 4:423-8, 2012; Surg Endosc 2:384-9, 2013; Surg Endosc 11:2110, 2007). METHODS: We present a case of a 40-year-old female, who underwent laparoscopic gastric bypass 6 years prior and subsequently developed marginal ulcer, resulting in chronic gastrojejunostomy stricture...
June 18, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29915557/enhanced-positive-emotional-reactivity-undermines-empathy-in-behavioral-variant-frontotemporal-dementia
#15
Alice Y Hua, Isabel J Sible, David C Perry, Katherine P Rankin, Joel H Kramer, Bruce L Miller, Howard J Rosen, Virginia E Sturm
Behavioral variant frontotemporal dementia (bvFTD) is a neurodegenerative disease characterized by profound changes in emotions and empathy. Although most patients with bvFTD become less sensitive to negative emotional cues, some patients become more sensitive to positive emotional stimuli. We investigated whether dysregulated positive emotions in bvFTD undermine empathy by making it difficult for patients to share (emotional empathy), recognize (cognitive empathy), and respond (real-world empathy) to emotions in others...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29915363/ghrelin-reductions-following-bariatric-surgery-were-associated-with-decreased-resting-state-activity-in-the-hippocampus
#16
Yi Zhang, Gang Ji, Guanya Li, Yang Hu, Li Liu, Qingchao Jin, Qianqian Meng, Jizheng Zhao, Kai Yuan, Jixn Liu, Karen M von Deneen, Antao Chen, Guangbin Cui, Huaning Wang, Qingchuan Zhao, Kaichun Wu, Jie Tian, Peter Manza, Dardo Tomasi, Nora D Volkow, Yongzhan Nie, Gene-Jack Wang
BACKGROUND/OBJECTIVE: Laparoscopic sleeve gastrectomy (LSG) is an effective bariatric surgery to treat obesity, and involves removal of the gastric fundus where ghrelin is mainly produced. Ghrelin stimulates appetite and regulates food intake through its effect on the hypothalamus and hippocampus (HIPP). While ghrelin's role on the hypothalamus has been explored, little is known about its role on HIPP. We tested the hypothesis that LSG-induced reductions in ghrelin levels would be associated with changes in HIPP activity...
June 18, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29915285/guided-morphogenesis-through-optogenetic-activation-of-rho-signalling-during-early-drosophila-embryogenesis
#17
Emiliano Izquierdo, Theresa Quinkler, Stefano De Renzis
During organismal development, cells undergo complex changes in shape whose causal relationship to individual morphogenetic processes remains unclear. The modular nature of such processes suggests that it should be possible to isolate individual modules, determine the minimum set of requirements sufficient to drive tissue remodeling, and re-construct morphogenesis. Here we use optogenetics to reconstitute epithelial folding in embryonic Drosophila tissues that otherwise would not undergo invagination. We show that precise spatial and temporal activation of Rho signaling is sufficient to trigger apical constriction and tissue folding...
June 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29915214/ventral-striatal-dysfunction-in-cocaine-dependence-difference-mapping-for-subregional-resting-state-functional-connectivity
#18
Sheng Zhang, Chiang-Shan R Li
Research of dopaminergic deficits has focused on the ventral striatum (VS) with many studies elucidating altered resting state functional connectivity (rsFC) in individuals with cocaine dependence (CD). The VS comprises functional subregions and delineation of subregional changes in rsFC requires careful consideration of the differences between addicted and healthy populations. In the current study, we parcellated the VS using whole-brain rsFC differences between CD and non-drug-using controls (HC). Voxels with similar rsFC changes formed functional clusters...
June 18, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29915137/monoamines-inhibit-gabaergic-neurons-in-ventrolateral-preoptic-area-that-make-direct-synaptic-connections-to-hypothalamic-arousal-neurons
#19
Yuki Saito, Takashi Maejima, Mitsuhiro Nishitani, Emi Hasegawa, Yuchio Yanagawa, Michihiro Mieda, Takeshi Sakurai
The hypothalamus plays an important role in regulation of sleep/wakefulness states. While the ventrolateral preoptic nucleus (VLPO) plays a critical role in the initiation and maintenance of sleep, the lateral posterior part of the hypothalamus contains neuronal populations implicated in maintenance of arousal, including orexin-producing neurons (orexin neurons) in the lateral hypothalamic area (LHA) and histaminergic neurons in the tuberomammillary nucleus (TMN). During a search for neurons that make direct synaptic contact with histidine decarboxylase (HDC)-positive, histaminergic neurons (HDC neurons) in the TMN and orexin neurons in the LHA of male mice, we found that these arousal-related neurons are heavily innervated by GABAergic neurons in the preoptic area (POA) including the VLPO...
June 18, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29915126/oct4-regulates-the-embryonic-axis-and-coordinates-exit-from-pluripotency-and-germ-layer-specification-in-the-mouse-embryo
#20
Carla Mulas, Gloryn Chia, Kenneth Alan Jones, Andrew Christopher Hodgson, Giuliano Giuseppe Stirparo, Jennifer Nichols
Lineage segregation in the mouse embryo is a finely controlled process dependent upon coordination of signalling pathways and transcriptional responses. Here we employ a conditional deletion system to investigate embryonic patterning and lineage specification in response to loss of Oct4. We first observe ectopic expression of Nanog in Oct4-negative postimplantation epiblast cells. The expression domains of lineage markers are subsequently disrupted. Definitive endoderm expands at the expense of mesoderm; the anterior-posterior axis is positioned more distally and an ectopic posterior-like domain appears anteriorly, suggesting a role for Oct4 in maintaining the embryonic axis...
June 18, 2018: Development
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