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Pattern hair loss

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https://www.readbyqxmd.com/read/28526588/adam10-and-%C3%AE-secretase-regulate-sensory-regeneration-in-the-avian-vestibular-organs
#1
Mark E Warchol, Jennifer Stone, Matthew Barton, Jeffrey Ku, Rose Veile, Nicolas Daudet, Michael Lovett
The loss of sensory hair cells from the inner ear is a leading cause of hearing and balance disorders. The mammalian ear has a very limited ability to replace lost hair cells, but the inner ears of non-mammalian vertebrates can spontaneously regenerate hair cells after injury. Prior studies have shown that replacement hair cells are derived from epithelial supporting cells and that the differentiation of new hair cells is regulated by the Notch signaling pathway. The present study examined molecular influences on regeneration in the avian utricle, which has a particularly robust regenerative ability...
May 16, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28503741/the-effect-of-autologous-activated-platelet-rich-plasma-injection-on-female-pattern-hair-loss-a-randomized-placebo-controlled-study
#2
Abeer Attia Tawfik, Mai Abdel Raouf Osman
BACKGROUND: Hair is an essential part of a woman's appearance and attractiveness. This is reflected in the predominantly psychological morbidity that can be associated with female pattern hair loss. Platelet-rich plasma(PRP) has been used in numerous fields of medicine. Recently, PRP has received growing attention as a potential therapeutic tool for hair loss. OBJECTIVE: To evaluate the efficacy and safety of autologous platelet-rich plasma in the treatment of female pattern hair loss...
May 14, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28502801/genome-wide-association-reveals-pigmentation-genes-play-a-role-in-skin-aging
#3
Matthew H Law, Sarah E Medland, Gu Zhu, Seyhan Yazar, Ana Viñuela, Leanne Wallace, Sri Niranjan Shekar, David L Duffy, Veronique Bataille, Dan Glass, Tim D Spector, Diane Wood, Scott D Gordon, Julie M Barbour, Anjali K Henders, Alex W Hewitt, Grant W Montgomery, Richard A Sturm, David A Mackey, Adèle C Green, Nicholas G Martin, Stuart MacGregor
Loss of fine skin patterning is a sign of both aging and photoaging. Studies investigating the genetic contribution to skin patterning offer an opportunity to better understand a trait that influences both physical appearance and risk of keratinocyte skin cancer. We undertook a meta-analysis of genome-wide association studies (GWAS) of a measure of skin pattern (microtopography score) damage in 1,671 twin pairs and 1,745 singletons (N = 5,087) drawn from three independent cohorts. We identified that rs185146 near SLC45A2 is associated with a skin aging trait (p = 4...
May 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28492055/hormonal-therapy-in-female-pattern-hair-loss
#4
REVIEW
Kevin R Brough, Rochelle R Torgerson
No abstract text is available yet for this article.
March 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28489273/low-level-light-minoxidil-5-combination-versus-either-therapeutic-modality-alone-in-management-of-female-patterned-hair-loss-a-randomized-controlled-study
#5
Samia M Esmat, Rehab A Hegazy, Heba I Gawdat, Rania M Abdel Hay, Riham S Allam, Rofaida El Naggar, Hoda Moneib
BACKGROUND: Female pattern hair loss (FPHL) is the most common form of hair loss in women. Nevertheless, its management represents a real challenge. Among the FDA approved therapeutic modalities for FPHL are topical minoxidil and more recently low-level light therapy (LLLT). AIM OF WORK: Assess the efficacy and safety of LLLT in comparison to topical minoxidil 5% and to a combination of both therapies in the treatment of FPHL. PATIENTS AND METHODS: This study included 45 female patients with proven FPHL...
May 10, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28474542/up-to-date-clinical-trials-of-hair-regeneration-using-conditioned-media-of-adipose-derived-stem-cells-in-male-and-female-pattern-hair-loss
#6
Hyoseung Shin, Chong Hyun Won, Woon-Kyung Chung, Byung-Soon Park
The primary roles of mesenchymal stem cells (MSCs) are to maintain the stem cell niche, facilitate recovery after injury, and ensure healthy aging and the homeostasis of organ and tissues. MSCs have recently emerged as a new therapeutic option for hair loss. Since adipose-derived stem cells (ADSCs) are the most accessible sources of MSCs, ADSC-based hair regeneration is currently under investigation. Besides replacing degenerated cells in affected organs, ADSCs exhibit their beneficial effects through the paracrine actions of various cytokines and growth factors...
May 4, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28460251/streptococcus-pneumoniae-induced-ototoxicity-in-organ-of-corti-explant-cultures
#7
Michael Perny, Magdalena Solyga, Denis Grandgirard, Marta Roccio, Stephen L Leib, Pascal Senn
Hearing loss remains the most common long-term complication of pneumococcal meningitis (PM) reported in up to 30% of survivors. Streptococcus pneumoniae have been shown to possess different ototoxic properties. Here we present a novel ex vivo experimental setup to examine in detail the pattern of hair cell loss upon exposure to different S. pneumoniae strains, therefore recapitulating pathogen derived aspects of PM-induced hearing loss. Our results show a higher susceptibility towards S. pneumoniae-induced cochlear damage for outer hair cells (OHC) compared to inner hair cells (IHC), which is consistent with in vivo data...
April 25, 2017: Hearing Research
https://www.readbyqxmd.com/read/28453904/genetics-and-other-factors-in-the-aetiology-of-female-pattern-hair-loss
#8
REVIEW
Silke Redler, Andrew G Messenger, Regina C Betz
Pattern hair loss is the most common form of hair loss in both women and men. Male pattern hair loss, also termed male androgenetic alopecia (M-AGA), is an androgen-dependent trait that is predominantly genetically determined. Androgen-mediated mechanisms are probably involved in FPHL in some women but the evidence is less strong than in M-AGA; and other non-androgenic pathways, including environmental influences, may contribute to the aetiology. Genome-wide association studies (GWASs) have identified several genetic loci for M-AGA and have provided better insight into the underlying biology...
April 28, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28438658/antioxidants-reduce-neurodegeneration-and-accumulation-of-pathologic-tau-proteins-in-the-auditory-system-after-blast-exposure
#9
Xiaoping Du, Matthew B West, Qunfeng Cai, Weihua Cheng, Donald L Ewert, Wei Li, Robert A Floyd, Richard D Kopke
Cochlear neurodegeneration commonly accompanies hair cell loss resulting from aging, ototoxicity, or exposures to intense noise or blast overpressures. However, the precise pathophysiological mechanisms that drive this degenerative response have not been fully elucidated. Our laboratory previously demonstrated that non-transgenic rats exposed to blast overpressures exhibited marked somatic accumulation of neurotoxic variants of the microtubule-associated protein, Tau, in the hippocampus. In the present study, we extended these analyses to examine neurodegeneration and pathologic Tau accumulation in the auditory system in response to blast exposure and evaluated the potential therapeutic efficacy of antioxidants on short-circuiting this pathological process...
April 22, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28436024/hair-diameter-evaluation-in-different-regions-of-the-safe-donor-area-in-asian-populations
#10
Jae H Park, Jae M Park, Na R Kim, Kotchamol Manonukul
BACKGROUND: There is little information about how hair diameter differences within the safe donor area. Thicker or thinner hair may be needed depending on the recipient area, hairline design, and surgical purpose. METHODS: Thirty-eight non-alopecic subjects (19 males and 19 females) were evaluated. The safe donor area was defined as the area contained within 28 cm from the horizontal plane of the upper border of the hair rim to the vertical line of the bilateral external acoustic meatus...
April 24, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28432872/human-effector-memory-t-helper-cells-engage-with-mouse-macrophages-and-cause-graft-versus-host-like-pathology-in-skin-of-humanized-mice-used-in-a-nonclinical-immunization-study
#11
Balasai Sundarasetty, Valery Volk, Sebastian J Theobald, Susanne Rittinghausen, Dirk Schaudien, Vanessa Neuhaus, Constanca Figueiredo, Andreas Schneider, Laura Gerasch, Adele Mucci, Thomas Moritz, Constantin von Kaisenberg, Loukia M Spineli, Katherina Sewald, Armin Braun, Henning Weigt, Arnold Ganser, Renata Stripecke
Humanized mice engrafted with human hematopoietic stem cells and developing functional human T-cell adaptive responses are in critical demand to test human-specific therapeutics. We previously showed that humanized mice immunized with long-lived induced-dendritic cells loaded with the pp65 viral antigen (iDCpp65) exhibited a faster development and maturation of T cells. Herein, we evaluated these effects in a long-term (36 weeks) nonclinical model using two stem cell donors to assess efficacy and safety. Relative to baseline, iDCpp65 immunization boosted the output of effector memory CD4(+) T cells in peripheral blood and lymph nodes...
June 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28420953/using-cochlear-microphonic-potentials-to-localize-peripheral-hearing-loss
#12
Karolina K Charaziak, Christopher A Shera, Jonathan H Siegel
The cochlear microphonic (CM) is created primarily by the receptor currents of outer hair cells (OHCs) and may therefore be useful for identifying cochlear regions with impaired OHCs. However, the CM measured across the frequency range with round-window or ear-canal electrodes lacks place-specificity as it is dominated by cellular sources located most proximal to the recording site (e.g., at the cochlear base). To overcome this limitation, we extract the "residual" CM (rCM), defined as the complex difference between the CM measured with and without an additional tone (saturating tone, ST)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28419572/genome-wide-differential-expression-profiling-of-long-non-coding-rnas-in-androgenetic-alopecia-in-a-chinese-male-population
#13
Linlin Bao, Aijiao Yu, Yaojia Luo, Tian Tian, Yuxi Dong, Haifeng Zong, Hongduo Chen, Xinghua Gao, Xuegang Xu, Yuanhong Li
BACKGROUND: Androgenetic alopecia (AGA), or male pattern baldness (MPB), is the most common form of hair loss in males. A combination of genetic and androgen causes have been suggested as factors that contribute to the development of AGA. However, the specific molecular mechanisms that underly AGA remain largely unknown. Long noncoding RNAs (lncRNAs), a new class of regulatory noncoding RNAs that are longer than 200 nucleotides, have been shown to play important roles in a number of cellular processes, including transcription, chromosome remodelling, and posttranscriptional processing...
April 17, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28408350/neuroactive-steroid-levels-and-psychiatric-and-andrological-features-in-post-finasteride-patients
#14
Roberto Cosimo Melcangi, Daniele Santi, Roberto Spezzano, Maria Grimoldi, Tommaso Tabacchi, Maria Letizia Fusco, Silvia Diviccaro, Silvia Giatti, Giuseppe Carrà, Donatella Caruso, Manuela Simoni, Guido Cavaletti
Recent reports show that, in patients treated with finasteride for male pattern hair loss, persistent side effects including sexual side effects, depression, anxiety and cognitive complaints may occur. We here explored the psychiatric and andrological features of patients affected by post-finasteride syndrome (PFS) and verified whether the cerebrospinal fluid (CSF) and plasma levels of neuroactive steroids (i.e., important regulators of nervous function) are modified. We found that eight out of sixteen PFS male patients considered suffered from a DSM-IV major depressive disorder (MDD)...
April 10, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28405549/cutaneous-manifestations-of-polycystic-ovary-syndrome-a-cross-sectional-clinical-study
#15
Mohammad Abid Keen, Iffat Hassan Shah, Gousia Sheikh
BACKGROUND: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, affecting 5-10% of reproductive-aged women. The dermatologic manifestations of hyperandrogenism, chiefly hirsutism, acne vulgaris, androgenic alopecia, and acanthosis nigricans, are among the cardinal manifestations of PCOS. AIM: To study the incidence and prevalence of various cutaneous manifestations in patients with PCOS and to correlate these skin manifestations with hormonal changes...
March 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28403520/study-of-gene-expression-alteration-in-male-androgenetic-alopecia-evidence-of-predominant-molecular-signaling-pathways
#16
L Michel, P Reygagne, P Benech, F Jean-Louis, S Scalvino, S Ly Ka So, Z Hamidou, S Bianovici, J Pouch, B Ducos, M Bonnet, A Bensussan, A Patatian, E Lati, J Wdzieczak-Bakala, J-C Choulot, E Loing, M Hocquaux
BACKGROUND: Male androgenetic alopecia (AGA) is the most common form of hair loss in men and is characterized by a distinct pattern of progressive hair loss starting from the frontal area and the vertex of the scalp. Although several genetic risk loci have been identified, relevant genes for AGA remain to be defined. OBJECTIVES: Herein, molecular biomarkers associated with premature AGA were identified through gene expression analysis using cDNA generated from scalp vertex biopsies of hairless/bald men with premature AGA and healthy volunteers...
April 12, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28396101/the-effectiveness-of-treatments-for-androgenetic-alopecia-a-systematic-review-and-meta-analysis
#17
REVIEW
Areej Adil, Marshall Godwin
BACKGROUND: Androgenetic alopecia, or male pattern hair loss, is a hair loss disorder mediated by dihydrotestosterone, the potent form of testosterone. Currently, minoxidil and finasteride are Food and Drug Administration (FDA)-approved, and HairMax LaserComb, which is FDA-cleared, are the only treatments recognized by the FDA as treatments of androgenetic alopecia. OBJECTIVE: This systematic review and meta-analysis assesses the efficacy of nonsurgical treatments of androgenetic alopecia in comparison to placebo for improving hair density, thickness, growth (defined by an increased anagen:telogen ratio), or subjective global assessments done by patients and investigators...
April 7, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28393993/-finasteride-adverse-effects-an-update
#18
Néstor Carreño-Orellana, Catherina Moll-Manzur, Juan Eduardo Carrasco-Zuber, Sergio Álvarez-Véliz, Daniela Berroeta-Mauriziano, Ninoska Porras-Kusmanic
Finasteride is a 5-α reductase inhibitor that is widely used in the management of benign prostate hyperplasia and male pattern hair loss. It is well known that these agents improve the quality of life in men suffering from these conditions. However, they are associated with some transient and even permanent adverse effects. The aim of this article is to clarify the controversies about the safety of finasteride by analyzing the evidence available in the literature.
December 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28392642/the-contributory-roles-of-th17-lymphocyte-and-cytotoxic-t-lymphocyte-at-the-hair-bulge-region-as-well-as-the-hair-bulb-area-in-the-chronic-alopecia-areata-patients
#19
Jin-Woo Hong, Chae-Young Lee, Seung-Min Ha, Seung-Hwan Choi, Tae-Hoon Kim, Ki-Hoon Song, Ki-Ho Kim
BACKGROUND: Alopecia areata (AA) is a T cell-mediated autoimmune disease that targets hair follicles and interrupts hair regrowth. The microenvironment of the effector T cells and their related cytokines may affect immunopathogenesis around the hair bulb/bulge. OBJECTIVE: To determine the contributory roles of the effector T cell subsets and related cytokines to the pathogenesis of AA. METHODS: We investigated the correlation between histopathological grades and four clinical prognostic factors in 331 patients with AA, and analyzed the topography of T cell infiltrates and related cytokines around the hair bulb/bulge according to histopathological grades through immunohistochemical and double immunofluorescence studies on a subset of AA specimens...
April 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28392345/lifestyle-and-physiological-factors-associated-with-facial-wrinkling-in-men-and-women
#20
Merel A Hamer, Luba M Pardo, Leonie C Jacobs, M Arfan Ikram, Joop S Laven, Manfred Kayser, Loes M Hollestein, David A Gunn, Tamar Nijsten
Facial wrinkling is one of the most notable signs of skin aging. Men and women show different wrinkling patterns yet the lifestyle and physiological factors underlying these sex-specific patterns are relatively unknown. Here, we investigated sex-specific determinants for facial wrinkles. Wrinkle area was quantified digitally using facial photographs of 3,831 north-western Europeans (51-98 years, 58% female). Effect estimates from multivariable linear regressions are presented as the percentage difference in the mean value of wrinkle area per unit increase of a determinant (%Δ)...
April 6, 2017: Journal of Investigative Dermatology
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