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Pattern hair loss

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https://www.readbyqxmd.com/read/29259106/identification-of-transcriptional-and-receptor-networks-that-control-root-responses-to-ethylene
#1
Alexandria F Harkey, Justin Watkins, Amy L Olex, Kathleen T DiNapoli, Daniel Lewis, Brad Binder, Jacquelyn S Fetrow, Gloria K Muday
Transcriptomic analyses with high temporal resolution provide substantial new insight into hormonal response networks. This study identified the kinetics of genome-wide transcript abundance changes in response to elevated levels of the plant hormone ethylene in roots from light grown Arabidopsis seedlings, which were overlaid on time matched developmental changes. Functional annotation of clusters of transcripts with similar temporal patterns revealed rapidly-induced clusters with known ethylene function, and more slowly regulated clusters with novel predicted functions linked to root development...
December 19, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29231239/female-pattern-hair-loss-a-pilot-study-investigating-combination-therapy-with-low-dose-oral-minoxidil-and-spironolactone
#2
Rodney D Sinclair
BACKGROUND: Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. OBJECTIVE: To report on a case series of women with pattern hair loss (PHL) treated with once daily minoxidil 0.25 mg and spironolactone 25 mg. METHODS: Women newly diagnosed with a Sinclair stage 2-5 PHL were scored for hair shedding and hair density before and after 12 months of treatment with oral minoxidil 0.25 mg and spironolactone 25 mg...
December 12, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29224108/negative-impact-of-testosterone-deficiency-and-5%C3%AE-reductase-inhibitors-therapy-on-metabolic-and-sexual-function-in-men
#3
Abdulmaged M Traish
Androgens are steroid hormones with pleotropic and diverse biochemical and physiological functions, and androgen deficiency exerts a negative impact on human health. Testosterone (T) either directly or via its transformation into the more potent metabolite 5α-dihydrotestosterone (5α-DHT) or via aromatization into estradiol (E2) modulates important biochemical signaling pathways of human physiology and plays a critical role in the growth and/or maintenance of functions in a host of tissues and organs. T and 5α-DHT play an important role in regulating physiology of the muscle, adipose tissue, liver, bone, and central nervous system, as well as reproductive and sexual functions...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29215595/the-role-of-vitamin-d-in-non-scarring-alopecia
#4
REVIEW
Agnieszka Gerkowicz, Katarzyna Chyl-Surdacka, Dorota Krasowska, Grażyna Chodorowska
Non-scarring hair loss is a common problem that affects both male and female patients. Since any disturbances in the hair follicle cycle may lead to hair shedding, or alopecia, it is not surprising that the possible role of vitamin D in alopecia was investigated in many studies. Vitamin D has been shown to have many important functions. A growing body of evidence shows that vitamin D and its receptor are responsible for maintaining not only calcium homeostasis but also skin homeostasis. Moreover, vitamin D could also regulate cutaneous innate and adaptive immunity...
December 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29212074/late-onset-alopecia-areata-a-retrospective-cohort-study
#5
Anna Lyakhovitsky, Sarit Gilboa, Anna Eshkol, Aviv Barzilai, Sharon Baum
BACKGROUND: Alopecia areata is an immune-mediated disease presenting with sudden onset of nonscarring hair loss. Onset is more common earlier in life, and little is known regarding late-onset alopecia areata. OBJECTIVES: To describe the epidemiology, clinical patterns, disease course, and outcome of late-onset alopecia areata in Israeli patients referred to a tertiary medical center. MATERIALS AND METHODS: This retrospective cohort study considered patients whose disease onset occurred at age ≥50 years...
December 7, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29189940/the-relationship-between-dietary-protein-content-body-condition-and-%C3%AE-15n-in-a-mammalian-omnivore
#6
Kelli L Hughes, John P Whiteman, Seth D Newsome
Seasonal reductions in food availability may cause animals to catabolize endogenous tissue and the resulting loss of lean mass can hinder their ability to forage and reproduce. While several studies have considered nitrogen isotopes (δ15N) as an indicator of catabolism, relationships between protein intake, body condition, and tissue δ15N have not been assessed simultaneously in controlled conditions. We conducted a feeding experiment on laboratory mice (Mus musculus) to test the effects of low (5%) versus high (30-40%) dietary protein content on lean mass, fat mass, and tissue δ15N...
November 30, 2017: Oecologia
https://www.readbyqxmd.com/read/29186269/aryl-hydrocarbon-receptor-overexpression-in-miniaturized-follicles-in-female-pattern-hair-loss
#7
Paulo Müller Ramos, Gabrielli Brianezi, Ana Carolina Pereira Martins, Márcia Guimarães da Silva, Mariângela Esther Alencar Marques, Hélio Amante Miot
The etiopathogenesis of female pattern hair loss is still poorly understood. In addition to genetic and hormonal elements, environmental factors could be involved. The aryl hydrocarbon receptor is expressed in keratinocytes and can be activated by environmental pollutants leading to alterations in the cell cycle, inflammation, and apoptosis. Here we demonstrate the overexpression of nuclear aryl hydrocarbon receptors in miniaturized hair follicles in female pattern hair loss.
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29185104/5%C3%AE-reductase-isozymes-and-aromatase-mrna-levels-in-plucked-hair-from-young-women-with-female-pattern-hair-loss
#8
P Sánchez, C Serrano-Falcón, J M Torres, S Serrano, E Ortega
Female pattern hair loss (FPHL) is an important hair disorder, especially when young women are affected. However, pharmacological treatments are not successful in all women. Androgens, especially dihydrotestosterone (DHT), may play a role in FPHL, but many women with this disorder have normal serum androgen levels. It therefore appears that hair follicle levels of DHT depend on in situ testosterone (T) metabolism. Because T can be converted to DHT or estradiol (E2) by 5α-reductase (5α-R) and aromatase, respectively, these enzymes would determine DHT and E2 concentrations and their ratio...
November 28, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29177154/syphilitic-alopecia-case-reports-and-trichoscopic-findings
#9
Isabella Doche, Maria K Hordinsky, Neusa Y S Valente, Ricardo Romiti, Antonella Tosti
There has been a resurgence of syphilis in the last decade. Although alopecia is not a common manifestation of the disease, the "moth-eaten" pattern is considered patognomonic. However, diffuse hair loss, termed essential alopecia, sometimes can be the only sign of syphilis infection and mimic other conditions, such as alopecia areata and telogen effluvium. We describe three patients with syphilis in whom the pattern of alopecia was not typical. Although clinical, histopathological, and trichoscopic examinations may share some similar findings with other hair diseases, the inclusion of syphilis in the differential diagnosis of hair loss causes is fundamental to a correct screening and diagnosis...
October 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29168293/changes-in-intraepidermal-nerve-fiber-and-langerhans-cell-densities-in-the-plantar-skin-of-rats-after-mercuric-chloride-exposure
#10
Binbin Sun, Shuangyi Fan, Kai Yao, Yifan Li, Xusheng Huang
BACKGROUND: Mercury and its compounds possess strong neurotoxicity, and patients with mercury poisoning often report pain and numbness in the distal extremities that conform to the "stocking-glove" pattern. However, no study has investigated whether damage to small nerve fibers is associated with mercury poisoning. The aims of the present study were to evaluate the effects of different doses of mercury chloride (HgCl2 ) on intraepidermal nerve fibers density (IENFD) and Langerhans cells (LCs) in the plantar skin of rats and to assess the possible relationship between changes in IENFD and sensory testing...
November 23, 2017: Journal of the Peripheral Nervous System: JPNS
https://www.readbyqxmd.com/read/29167734/treatment-of-chronic-telogen-effluvium-with-oral-minoxidil-a-retrospective-study
#11
Eshini Perera, Rodney Sinclair
Background: Chronic telogen effluvium (CTE) may be primary or secondary to various causes, including drug reaction, nutritional deficiency and female pattern hair loss (FPHL).  Oral minoxidil stimulates hair growth, and topical minoxidil is used in the treatment of FPHL and male androgenetic alopecia. minoxidil has not been used to treat CTE. This study aimed to assess the treatment of CTE with once daily oral minoxidil. Methods: Women with a diagnosis of CTE based on >6 month history of increased telogen hair shedding, no visible mid frontal scalp hair loss (Sinclair stage 1) and no hair follicle miniaturization on scalp biopsy were treated with once daily oral minoxidil...
2017: F1000Research
https://www.readbyqxmd.com/read/29136266/prostanoids-and-hair-follicles-implications-for-therapy-of-hair-disorders
#12
Xue-Gang Xu, Hong-Duo Chen
Prostanoids, including prostaglandins (PGs) and thromboxane A2 (TXA2), are a family of lipid-derived autacoids that modulate many physiological systems and pathological contexts. Prostanoids are generated by sequential metabolism of arachidonic acid, catalysed by cyclo-oxygenase, to PGH2, which is then converted to PGD2, PGE2, PGF2α, PGI2 and TXA2, catalysed by their specific synthases. Recent evidence suggests that prostanoids play a role in regulating hair growth. The PGF2α analogue is Food and Drug Administration-approved and routinely used to enhance the growth of human eyelashes...
November 14, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29094203/creation-of-miniature-pig-model-of-human-waardenburg-syndrome-type-2a-by-enu-mutagenesis
#13
Tang Hai, Weiwei Guo, Jing Yao, Chunwei Cao, Ailing Luo, Meng Qi, Xianlong Wang, Xiao Wang, Jiaojiao Huang, Ying Zhang, Hongyong Zhang, Dayu Wang, Haitao Shang, Qianlong Hong, Rui Zhang, Qitao Jia, Qiantao Zheng, Guosong Qin, Yongshun Li, Tao Zhang, Weiwu Jin, Zheng-Yi Chen, Hongmei Wang, Qi Zhou, Anming Meng, Hong Wei, Shiming Yang, Jianguo Zhao
Human Waardenburg syndrome 2A (WS2A) is a dominant hearing loss (HL) syndrome caused by mutations in the microphthalmia-associated transcription factor (MITF) gene. In mouse models with MITF mutations, WS2A is transmitted in a recessive pattern, which limits the study of hearing loss (HL) pathology. In the current study, we performed ENU (ethylnitrosourea) mutagenesis that resulted in substituting a conserved lysine with a serine (p. L247S) in the DNA-binding domain of the MITF gene to generate a novel miniature pig model of WS2A...
November 1, 2017: Human Genetics
https://www.readbyqxmd.com/read/29084289/neuronal-differentiation-of-hair-follicle-bulge-derived-stem-cells-co-cultured-with-mouse-cochlear-modiolus-explants
#14
Timo Schomann, Laura Mezzanotte, John C M J De Groot, Marcelo N Rivolta, Sanne H Hendriks, Johan H M Frijns, Margriet A Huisman
Stem-cell-based repair of auditory neurons may represent an attractive therapeutic option to restore sensorineural hearing loss. Hair-follicle-bulge-derived stem cells (HFBSCs) are promising candidates for this type of therapy, because they (1) have migratory properties, enabling migration after transplantation, (2) can differentiate into sensory neurons and glial cells, and (3) can easily be harvested in relatively high numbers. However, HFBSCs have never been used for this purpose. We hypothesized that HFBSCs can be used for cell-based repair of the auditory nerve and we have examined their migration and incorporation into cochlear modiolus explants and their subsequent differentiation...
2017: PloS One
https://www.readbyqxmd.com/read/29059194/role-of-neuropilin-1-semaphorin-3a-signaling-in-the-functional-and-morphological-integrity-of-the-cochlea
#15
Pezhman Salehi, Marshall X Ge, Usha Gundimeda, Leah Michelle Baum, Homero Lael Cantu, Joel Lavinsky, Litao Tao, Anthony Myint, Charlene Cruz, Juemei Wang, Angeliki Maria Nikolakopoulou, Carolina Abdala, Matthew William Kelley, Takahiro Ohyama, Thomas Matthew Coate, Rick A Friedman
Neuropilin-1 (Nrp1) encodes the transmembrane cellular receptor neuropilin-1, which is associated with cardiovascular and neuronal development and was within the peak SNP interval on chromosome 8 in our prior GWAS study on age-related hearing loss (ARHL) in mice. In this study, we generated and characterized an inner ear-specific Nrp1 conditional knockout (CKO) mouse line because Nrp1 constitutive knockouts are embryonic lethal. In situ hybridization demonstrated weak Nrp1 mRNA expression late in embryonic cochlear development, but increased expression in early postnatal stages when cochlear hair cell innervation patterns have been shown to mature...
October 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29055061/preservation-of-stem-cells-in-androgenetic-alopecia
#16
LETTER
H Gamil, M Assaf, M Elsayed, K Gharib, M Soliman, N A Mostafa
No abstract text is available yet for this article.
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29054497/association-between-male-pattern-baldness-and-prostate-disease-a-meta-analysis
#17
Tao Jin, Tao Wu, Zhumei Luo, Xi Duan, Shi Deng, Yin Tang
BACKGROUND: Male pattern baldness (MPB) has been associated with an increased risk of prostate cancer (PC) as well as benign prostatic hyperplasia (BPH). We performed a meta-analysis to quantitatively determine the level of risk of PC and BPH in individuals with baldness. METHODS: A systematic literature search was conducted using several databases. We calculated pooled odds ratios (OR) and 95% CIs. RESULTS: In total, 17 studies comprising 68,448 participants were eligible for the meta-analysis and showed that MPB is associated with an increased risk of aggressive PC (OR = 1...
October 17, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29054432/expression-pattern-of-eya4-in-the-common-marmoset-callithrix-jacchus-cochlea
#18
Saeko Matsuzaki, Makoto Hosoya, Hideyuki Okano, Masato Fujioka, Kaoru Ogawa
The eyes absent (EYA)-like genes are essential for the formation of sensory organs among fly (Drosophila melanogaster) and mammals. EYA4, one of the vertebrate genes of Eya family, is reported to be causative for late-onset mid-frequency sensorineural hearing loss in humans, while Eya4-deficient mice exhibited congenital profound deafness and otitis media with effusion due to the eustachian tube dysmorphology. Because of the species difference in the phenotype, the pathophysiology of EYA4 in the human cochlea has yet to be elucidated...
October 18, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29035284/traction-alopecia-a-neglected-entity-in-2017
#19
REVIEW
Christiana Oyinlola Akingbola, Jui Vyas
Traction alopecia was first described in 1904 but is still a cause of scarring hair loss in young women worldwide. It is unique in being initially a reversible then an irreversible (scarring) form of alopecia. Linked to tightly-pulled hairstyles, it is seen across all races. The pattern of hair loss depends on the style creating it but most commonly affects the frontotemporal hairline. There are some new examination findings associated with traction alopecia, which are traction folliculitis, the fringe sign and hair casts (pseudonits) on dermatoscopy...
November 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29028860/-man-some-a-review-of-male-facial-aging-and-beauty
#20
Terrence Colin Keaney
<p>Gender plays a significant role in determining facial anatomy and behavior, both of which are key factors in the aging process. Understanding the pattern of male facial aging is critical when planning aesthetic treatments on men. Men develop more severe rhytides in a unique pattern, show increased periocular aging changes, and are more prone to hair loss. What also needs to be considered when planning a treatment is what makes men beautiful or "man-some". Male beauty strikes a balance between masculine and feminine facial features...
June 1, 2017: Journal of Drugs in Dermatology: JDD
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