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https://www.readbyqxmd.com/read/27925662/clinical-and-pathological-features-of-hair-coat-abnormalities-in-curly-coated-retrievers-from-uk-and-sweden
#1
R Bond, K Varjonen, A Hendricks, Y M Chang, H Brooks Brownlie
OBJECTIVES: To gain information on hair loss amongst curly coated retrievers by questionnaire and to define the clinical and pathological features of hair coat abnormalities in affected dogs in the United Kingdom and Sweden. MATERIALS AND METHODS: Questionnaires were completed by members of the Curly Coated Retriever Clubs. Fourteen dogs (six in the United Kingdom, eight in Sweden) were clinically examined and skin/hair samples collected for microscopy and histopathology...
December 2016: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/27925611/differential-expression-of-bcl-2-in-the-cochlea-and-auditory-cortex-of-a-mouse-model-of-age-related-hearing-loss
#2
Qiuhong Huang, Hao Xiong, Haidi Yang, Yongkang Ou, Zhigang Zhang, Suijun Chen, Yongyi Ye, Yiqing Zheng
Bcl-2, the first gene shown to be involved in apoptosis, is a potent regulator of cell survival and known to have protective effects against a variety of age-related diseases. However, the possible relationship between hearing and Bcl-2 expression in the cochlea or auditory cortex of C57BL/6 mice, a mouse model of age-related hearing loss, is still unknown. Using RT-PCR, immunohistochemistry, and Western blot analysis, our results show that Bcl-2 is strongly expressed in the inner hair cells and spiral ganglion neurons of young mice...
December 8, 2016: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/27915094/clinical-features-associated-with-ctnnb1-de-novo-loss-of-function-mutations-in-ten-individuals
#3
Mira Kharbanda, Daniela T Pilz, Susan Tomkins, Kate Chandler, Anand Saggar, Alan Fryer, Victoria McKay, Pedro Louro, Jill Clayton Smith, John Burn, Usha Kini, Anna De Burca, David R FitzPatrick, Esther Kinning
Loss of function mutations in CTNNB1 have been reported in individuals with intellectual disability [MIM #615075] associated with peripheral spasticity, microcephaly and central hypotonia, suggesting a recognisable phenotype associated with haploinsufficiency for this gene. Trio based whole exome sequencing via the Deciphering Developmental Disorders (DDD) study has identified eleven further individuals with de novo loss of function mutations in CTNNB1. Here we report detailed phenotypic information on ten of these...
November 30, 2016: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/27904180/evaluation-of-clinical-significance-of-dermoscopy-in-alopecia-areata
#4
Akhila Sai Guttikonda, Chintaginjala Aruna, D V S B Ramamurthy, K Sridevi, Senthil Kumar L Alagappan
BACKGROUND: Alopecia areata (AA) is a common, chronic inflammatory disease characterized by nonscarring hair loss on the scalp or any hair-bearing area of the body. Recently, dermoscopy, a noninvasive diagnostic procedure, has been employed for the diagnosis of AA. AIM: To evaluate various dermoscopic patterns in AA and correlate these patterns with the disease activity and severity. MATERIALS AND METHODS: Dermoscopy was performed on AA patients using DL1 dermoscope (magnification ×10 was used)...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27890673/functional-validation-of-abhd12-mutations-in-the-neurodegenerative-disease-pharc
#5
Angèle Tingaud-Sequeira, Demetrio Raldúa, Julie Lavie, Guilaine Mathieu, Magali Bordier, Anja Knoll-Gellida, Pierre Rambeau, Isabelle Coupry, Michèle André, Eva Malm, Claes Möller, Sten Andreasson, Nanna D Rendtorff, Lisbeth Tranebjærg, Michel Koenig, Didier Lacombe, Cyril Goizet, Patrick J Babin
ABHD12 mutations have been linked to neurodegenerative PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and early-onset cataract), a rare, progressive, autosomal, recessive disease. Although ABHD12 is suspected to play a role in the lysophosphatidylserine and/or endocannabinoid pathways, its precise functional role(s) leading to PHARC disease had not previously been characterized. Cell and zebrafish models were designed to demonstrate the causal link between an identified new missense mutation p...
November 23, 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/27866090/relationship-between-anxiety-disorders-and-domains-of-health-related-quality-of-life-among-nigerians-with-breast-cancer
#6
Olamijulo Adedeji Fatiregun, Andrew Toyin Olagunju, Adebayo Rasheed Erinfolami, Olubunmi Ayodele Arogunmati, Omolara Amina Fatiregun, Joseph Dada Adeyemi
PURPOSE: Health Related Quality of life (HRQoL) is increasingly recognised as an important indicator of outcome and well-being in oncology care. We set out in this study to evaluate whether significant association exists between anxiety disorders (ADs) and HRQoL in breast cancer, such that any intervention addressing ADs would potentially improve HRQoL. METHODS: A cross sectional evaluation of 200 attendees of an oncology clinic was done using designed questionnaire to gather socio-demographic and clinical data...
November 17, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27859195/energetic-costs-of-mange-in-wolves-estimated-from-infrared-thermography
#7
P C Cross, E S Almberg, C G Haase, P J Hudson, S K Maloney, M C Metz, A J Munn, P Nugent, O Putzeys, D R Stahler, A C Stewart, D W Smith
Parasites, by definition, extract energy from their hosts and thus affect trophic and food web dynamics even when the parasite may have limited effects on host population size. We studied the energetic costs of mange (Sarcoptes scabiei) in wolves (Canis lupus) using thermal cameras to estimate heat losses associated with compromised insulation during the winter. We combined the field data of known, naturally infected wolves with a data set on captive wolves with shaved patches of fur as a positive control to simulate mange-induced hair loss...
August 2016: Ecology
https://www.readbyqxmd.com/read/27853485/study-on-the-efficacy-of-platelet-rich-fibrin-matrix-in-hair-follicular-unit-transplantation-in-androgenetic-alopecia-patients
#8
Sandeep Mahapatra, Dhruva Kumar, Vignesh Subramanian, Swarup K Chakrabarti, Kaushik D Deb
Objective: Hair loss is a significant problem worldwide. The most common cause of hair loss in men is male androgenetic alopecia, male pattern baldness, which is primarily due to the presence of nonfunctional or dead hair follicles in the scalp. Hair follicular unit transplantation has been a widely used technique to transplant hair follicles into bald areas. Although follicular unit transplantation generally gives satisfactory hair transplantation, efforts have been made to further increase the efficacy of follicular unit transplantation in hair regeneration...
September 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27843917/differential-diagnosis-of-female-pattern-hair-loss
#9
Daniel Asz-Sigall, Ana Cecilia González-de-Cossio-Hernández, Erika Rodríguez-Lobato, María Fernanda Ortega-Springall, Maria Elisa Vega-Memije, Roberto Arenas Guzmán
No abstract text is available yet for this article.
September 2016: Skin Appendage Disorders
https://www.readbyqxmd.com/read/27831874/content-adaptive-sketch-portrait-generation-by-decompositional-representation-learning
#10
Dongyu Zhang, Liang Lin, Tianshui Chen, Xian Wu, Wenwei Tan, Ebroul Izquierdo
Sketch portrait generation benefits a wide range of applications such as digital entertainment and law enforcement. Although plenty of efforts have been dedicated to this task, several issues still remain unsolved for generating vivid and detail-preserving personal sketch portraits. For example, quite a few artifacts may exist in synthesizing hairpins and glasses, and textural details may be lost in the regions of hair or mustache. Moreover, the generalization ability of current systems is somewhat limited since they usually require elaborately collecting a dictionary of examples or carefully tuning features/components...
January 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/27830323/study-of-frontal-hairline-patterns-for-natural-design-and-restoration
#11
Suzan Sirinturk, Hassan Bagheri, Figen Govsa, Yelda Pinar, Mehmet Asim Ozer
OBJECTIVE: Hair loss is one of the most noticeable esthetic problems of the mankind. Hair transplantation has been a highly effective technique in reducing wide foreheads and recontouring the hairline. Creating a natural hairline is one of the most important elements of a successful hair transplant. This study aims at the requirements which are essential in designing hairline morphometrics and natural frontline. METHODS: Standard photographs of the forehead region were obtained from two hundred young Turkish adults participated in this study...
November 10, 2016: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/27785535/-conversion-of-sound-into-auditory-nerve-action-potentials
#12
J Encke, J Kreh, F Völk, W Hemmert
Outer hair cells play a major role in the hearing process: they amplify the motion of the basilar membrane up to a 1000-fold and at the same time sharpen the excitation patterns. These patterns are converted by inner hair cells into action potentials of the auditory nerve. Outer hair cells are delicate structures and easily damaged, e. g., by overexposure to noise. Hearing aids can amplify the amplitude of the excitation patterns, but they cannot restore their degraded frequency selectivity. Noise overexposure also leads to delayed degeneration of auditory nerve fibers, particularly those with low a spontaneous rate, which are important for the coding of sound in noise...
October 26, 2016: HNO
https://www.readbyqxmd.com/read/27769922/styrene-enhances-the-noise-induced-oxidative-stress-in-the-cochlea-and-affects-differently-mechanosensory-and-supporting-cells
#13
REVIEW
A R Fetoni, R Rolesi, F Paciello, S L M Eramo, C Grassi, D Troiani, G Paludetti
Experimental and human investigations have raised the level of concern about the potential ototoxicity of organic solvents and their interaction with noise. The main objective of this study was to characterize the effects of the combined noise and styrene exposure on hearing focusing on the mechanism of damage on the sensorineural cells and supporting cells of the organ of Corti and neurons of the ganglion of Corti. The impact of single and combined exposures on hearing was evaluated by auditory functional testing and histological analyses of cochlear specimens...
October 18, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27754889/the-zebrafish-homologs-of-set-i2pp2a-oncoprotein-expression-patterns-and-insights-into-their-physiological-roles-during-development
#14
Iliana Serifi, Eleni Tzima, Katerina Soupsana, Zoe Karetsou, Dimitris Beis, Thomais Papamarcaki
The oncoprotein SET/I2PP2A participates in various cellular mechanisms such as transcription, cell cycle regulation and cell migration. SET is also an inhibitor of the serine/threonine phosphatase PP2A, which is involved in the regulation of cell homeostasis. In zebrafish there are two paralogous set genes that encode Seta (269 aa) and Setb (275 aa) proteins which share 94% identity. We show here that seta and set b are similarly expressed in the eye, the otic vesicle, the brain and the lateral line system, as indicated by in situ hybridization labeling...
October 17, 2016: Biochemical Journal
https://www.readbyqxmd.com/read/27747798/traditional-anticoagulants-and-hair-loss-a-role-for-direct-oral-anticoagulants-a-review-of-the-literature
#15
Magdalena M Watras, Jignesh P Patel, Roopen Arya
Hair loss is associated with the anticoagulants heparin and warfarin. With the recent availability of direct oral anticoagulants (DOACs) it is of clinical interest to know if they are implicated with hair loss and/or whether they could be successfully prescribed for patients who suffer from coumarin- or heparin-related alopecia. Initially reports of heparin- and coumarin-associated alopecia available through PubMed and Medline were explored in order to establish the cause of this side effect. Currently there is a lack of unanimity on why anticoagulants cause alopecia...
March 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27712018/prevalence-of-hair-shedding-among-women
#16
Maja Kovacevic, Andy Goren, Jerry Shapiro, Rodney Sinclair, Neal M Lonky, Mirna Situm, Vedrana Bulat, Zeljana Bolanca, John McCoy
Hair shedding in female patients is a frequent complaint in dermatological, endocrinological, and gynecological consults. Previously, the Sinclair Hair Shedding Scale was developed to assess normal versus excessive hair shedding in female pattern hair loss (FPHL) subjects. However, the prevalence of hair shedding in females not suffering from FPHL is unknown. To gain better understanding of hair shedding in the general population, we recruited 300 subjects visiting a public hospital for conditions other than alopecia...
October 6, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27695865/efficacy-and-safety-of-5-minoxidil-topical-foam-in-male-pattern-hair-loss-treatment-and-patient-satisfaction
#17
Hournaz Hasanzadeh, Saman Ahmad Nasrollahi, Nader Halavati, Maryam Saberi, Alireza Firooz
INTRODUCTION: Male pattern hair loss is widespread around the world. Its prevalence indicates the importance of finding the best treatment modalities. This study evaluates the efficacy and safety of minoxidil 5% topical foam in male pattern hair loss treatment and patient satisfaction. METHODS: This study was a before-and-after trial on 17 male patients with male pattern hair loss. Subjects were instructed to apply one capful (1 ml) of minoxidil 5% topical foam on the scalp daily for 6 months...
September 2016: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/27688442/dermatoses-among-children-from-celebration-of-holi-the-spring-festival-in-india-a-cross-sectional-observational-study
#18
Sudip Kumar Ghosh, Debabrata Bandyopadhyay, Megha Agarwal, Olympia Rudra
BACKGROUND: "Holi" is a spring festival celebrated primarily in the Indian subcontinent and also abroad by expatriate Indians. It is a festival of colors, traditionally celebrated by mutual application of colors in different forms on a particular day of the year. These colors frequently comprise a range of synthetic dyes which have harmful effects on the skin and mucosae. Children take part in this colorful festival with much enthusiasm and vigor, making them prone to develop different "Holi"-related dermatoses...
September 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27661430/a-new-subtype-of-lichen-planopilaris-affecting-vellus-hairs-and-clinically-mimicking-androgenetic-alopecia
#19
Ali Abbasi, Kambiz Kamyab-Hesari, Ramin Rabbani, Farzaneh Mollaee, Sheida Abbasi
BACKGROUND: Lichen planopilaris (LPP) is a follicular variant of lichen planus. A new subtype of LPP mimicking androgenetic alopecia (AGA) may be misdiagnosed. Inappropriate medical therapy or hair transplantation may exacerbate this subtype. OBJECTIVE: To introduce clinicopathologic findings of a new subtype of LPP that selectively affects vellus hair in the pattern of AGA. MATERIALS AND METHODS: In a cross-sectional study, 433 (66.6%) men and 217 (33...
October 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27650741/female-pattern-hair-loss-biological-ageing-and-the-leiden-longevity-study
#20
R Sinclair
No abstract text is available yet for this article.
October 2016: British Journal of Dermatology
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