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Pattern hair loss

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https://www.readbyqxmd.com/read/28740409/hair-follicle-growth-by-stromal-vascular-fraction-enhanced-adipose-transplantation-in-baldness
#1
David Perez-Meza, Craig Ziering, Marcos Sforza, Ganesh Krishnan, Edward Ball, Eric Daniels
Great interest remains in finding new and emerging therapies for the treatment of male and female pattern hair loss. The autologous fat grafting technique is >100 years old, with a recent and dramatic increase in clinical experience over the past 10-15 years. Recently, in 2001, Zuk et al published the presence of adipose-derived stem cells, and abundant research has shown that adipose is a complex, biological active, and important tissue. Festa et al, in 2011, reported that adipocyte lineage cells support the stem cell niche and help drive the complex hair growth cycle...
2017: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/28728330/hair-diameter-variation-in-different-vertical-regions-of-the-occipital-safe-donor-area
#2
Seon Sik Yun, Jae Hyun Park, Young Cheon Na
BACKGROUND: Little is known concerning hair diameter variation within the safe donor area for hair transplantation surgery. Thicker or thinner hair may be needed, depending on the recipient area, hairline design, and the purpose of surgery. METHODS: Twenty-seven patients (7 men and 20 women; mean age, 28 years; range, 20-47 years) were included in this study. The midoccipital point was used as the reference point on the horizontal plane at the upper border of the helical rim...
July 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28722458/-androgenetic-alopecia-in-women
#3
Jana Krabcová
Androgenetic alopecia is one of the most common diagnoses in a hair clinic. It is non-scarring pattern hair losses that affect individuals, independent on severity, age and gender. The incidence of AGA increases within the age. AGA affects women less frequently, is usually milder and is associated with diffuse thinning of the hair scalp. Prompt diagnosis and treatment are essential for obtaining optimal outcome.
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28679963/transgenic-mice-display-hair-loss-and-regrowth-overexpressing-mutant-hr-gene
#4
Kuicheng Zhu, Cunshuan Xu, Jintao Zhang, Yingying Chen, Mengduan Liu
Mutations in the hairless (Hr) gene in both mice and humans have been implicated in the development of congenital atrichia, but the role of Hr in skin and hair follicle (HF) biology remains unknown. Here, we established transgenic mice (TG) overexpressing mutant Hr to investigate its specific role in the development of HF. Three transgenic lines were successfully constructed, and two of them (TG3 and TG8) displayed a pattern of hair loss and regrowth with alternation in the expression of HR protein. The mutant Hr gene inhibited the expression of the endogenous gene in transgenic individuals, which led to the development of alopecia...
July 5, 2017: Experimental Animals
https://www.readbyqxmd.com/read/28668292/a-longitudinal-study-of-diurnal-cortisol-patterns-and-associated-factors-in-breast-cancer-patients-from-the-transition-stage-of-the-end-of-active-cancer-treatment-to-post-treatment-survivorship
#5
Fei-Hsiu Hsiao, Guey-Mei Jow, Wen-Hung Kuo, Ming-Yang Wang, King-Jen Chang, Yu-Ming Lai, Yu-Ting Chen, Chiun-Sheng Huang
OBJECTIVES: The aim of this study was to examine the changes in diurnal cortisol patterns and its associated factors among breast cancer patients over a 14-month follow up period. MATERIALS AND METHODS: A total of 85 breast cancer patients were recruited to participate in this study. Assessments were performed at baseline (T0), T1 (the 2nd month), T2 (the 5th month), T3 (the 8th month), and T4 (the 14th month). Salivary cortisol was measured and the following questionnaires were administered: BDI-II depression scale, European Organization for Research and Treatment of Cancer Core Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and its breast cancer-specific complementary measure (EORTC QLQ-BR23)...
June 28, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28618834/psychophysical-and-modeling-approaches-towards-determining-the-cochlear-phase-response-based-on-interaural-time-differences
#6
Hisaaki Tabuchi, Bernhard Laback
The cochlear phase response is often estimated by measuring masking of a tonal target by harmonic complexes with various phase curvatures. Maskers yielding most modulated internal envelope representations after passing the cochlear filter are thought to produce minimum masking, with fast-acting cochlear compression as the main contributor to that effect. Thus, in hearing-impaired (HI) listeners, reduced cochlear compression hampers estimation of the phase response using the masking method. This study proposes an alternative approach, based on the effect of the envelope modulation strength on the sensitivity to interaural time differences (ITDs)...
June 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28611622/psoriatic-alopecia-in-a-patient-with-systemic-lupus-erythematosus
#7
Wimolsiri Iamsumang, Tueboon Sriphojanart, Poonkiat Suchonwanit
Psoriasis is a chronic, recurrent, and relatively common inflammatory dermatologic condition, which demonstrates various clinical manifestations including hair loss. It was once believed that alopecia was not a presentation of scalp psoriasis, but it is now widely accepted that psoriatic alopecia exists. Although the majority of patients get hair regrowth, it can potentially lead to permanent hair loss. Herein, we report a case of 26-year-old female patient with systemic lupus erythematosus who presented with scalp hair loss and nonpruritic scaly plaques on the scalp...
January 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28589172/genome-wide-gene-expression-dataset-used-to-identify-potential-therapeutic-targets-in-androgenetic-alopecia
#8
R Dey-Rao, A A Sinha
The microarray dataset attached to this report is related to the research article with the title: "A genomic approach to susceptibility and pathogenesis leads to identifying potential novel therapeutic targets in androgenetic alopecia" (Dey-Rao and Sinha, 2017) [1]. Male-pattern hair loss that is induced by androgens (testosterone) in genetically predisposed individuals is known as androgenetic alopecia (AGA). The raw dataset is being made publicly available to enable critical and/or extended analyses. Our related research paper utilizes the attached raw dataset, for genome-wide gene-expression associated investigations...
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28566902/therapeutic-efficacy-of-a-combination-therapy-of-topical-17%C3%AE-estradiol-and-topical-minoxidil-on-female-pattern-hair-loss-a-noncomparative-retrospective-evaluation
#9
Sung Jay Choe, Solam Lee, Jaewoong Choi, Won-Soo Lee
BACKGROUND: A variety of agents have been used to treat female pattern hair loss (FPHL), including topical minoxidil, topical 17α-estradiol, oral anti-androgen agents, and mineral supplements. Compared with these single agent regimens, combination therapies could be a better therapeutic option in expectation of superior treatment outcome. OBJECTIVE: This study was designed to determine the efficacy of a combination therapy consisting of topical 0.025% 17α-estradiol and 3% minoxidil in Korean patients with FPHL...
June 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28526588/adam10-and-%C3%AE-secretase-regulate-sensory-regeneration-in-the-avian-vestibular-organs
#10
Mark E Warchol, Jennifer Stone, Matthew Barton, Jeffrey Ku, Rose Veile, Nicolas Daudet, Michael Lovett
The loss of sensory hair cells from the inner ear is a leading cause of hearing and balance disorders. The mammalian ear has a very limited ability to replace lost hair cells, but the inner ears of non-mammalian vertebrates can spontaneously regenerate hair cells after injury. Prior studies have shown that replacement hair cells are derived from epithelial supporting cells and that the differentiation of new hair cells is regulated by the Notch signaling pathway. The present study examined molecular influences on regeneration in the avian utricle, which has a particularly robust regenerative ability...
August 1, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28503741/the-effect-of-autologous-activated-platelet-rich-plasma-injection-on-female-pattern-hair-loss-a-randomized-placebo-controlled-study
#11
Abeer Attia Tawfik, Mai Abdel Raouf Osman
BACKGROUND: Hair is an essential part of a woman's appearance and attractiveness. This is reflected in the predominantly psychological morbidity that can be associated with female pattern hair loss. Platelet-rich plasma(PRP) has been used in numerous fields of medicine. Recently, PRP has received growing attention as a potential therapeutic tool for hair loss. OBJECTIVE: To evaluate the efficacy and safety of autologous platelet-rich plasma in the treatment of female pattern hair loss...
May 14, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28502801/genome-wide-association-reveals-pigmentation-genes-play-a-role-in-skin-aging
#12
Matthew H Law, Sarah E Medland, Gu Zhu, Seyhan Yazar, Ana Viñuela, Leanne Wallace, Sri Niranjan Shekar, David L Duffy, Veronique Bataille, Dan Glass, Tim D Spector, Diane Wood, Scott D Gordon, Julie M Barbour, Anjali K Henders, Alex W Hewitt, Grant W Montgomery, Richard A Sturm, David A Mackey, Adèle C Green, Nicholas G Martin, Stuart MacGregor
Loss of fine skin patterning is a sign of both aging and photoaging. Studies investigating the genetic contribution to skin patterning offer an opportunity to better understand a trait that influences both physical appearance and risk of keratinocyte skin cancer. We undertook a meta-analysis of genome-wide association studies (GWAS) of a measure of skin pattern (microtopography score) damage in 1,671 twin pairs and 1,745 singletons (N = 5,087) drawn from three independent cohorts. We identified that rs185146 near SLC45A2 is associated with a skin aging trait (p = 4...
May 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28492055/hormonal-therapy-in-female-pattern-hair-loss
#13
REVIEW
Kevin R Brough, Rochelle R Torgerson
No abstract text is available yet for this article.
March 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28489273/low-level-light-minoxidil-5-combination-versus-either-therapeutic-modality-alone-in-management-of-female-patterned-hair-loss-a-randomized-controlled-study
#14
Samia M Esmat, Rehab A Hegazy, Heba I Gawdat, Rania M Abdel Hay, Riham S Allam, Rofaida El Naggar, Hoda Moneib
BACKGROUND: Female pattern hair loss (FPHL) is the most common form of hair loss in women. Nevertheless, its management represents a real challenge. Among the FDA approved therapeutic modalities for FPHL are topical minoxidil and more recently low-level light therapy (LLLT). AIM OF WORK: Assess the efficacy and safety of LLLT in comparison to topical minoxidil 5% and to a combination of both therapies in the treatment of FPHL. PATIENTS AND METHODS: This study included 45 female patients with proven FPHL...
May 10, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28474542/up-to-date-clinical-trials-of-hair-regeneration-using-conditioned-media-of-adipose-derived-stem-cells-in-male-and-female-pattern-hair-loss
#15
Hyoseung Shin, Chong Hyun Won, Woon-Kyung Chung, Byung-Soon Park
The primary roles of mesenchymal stem cells (MSCs) are to maintain the stem cell niche, facilitate recovery after injury, and ensure healthy aging and the homeostasis of organ and tissues. MSCs have recently emerged as a new therapeutic option for hair loss. Since adipose-derived stem cells (ADSCs) are the most accessible sources of MSCs, ADSC-based hair regeneration is currently under investigation. Besides replacing degenerated cells in affected organs, ADSCs exhibit their beneficial effects through the paracrine actions of various cytokines and growth factors...
May 4, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28460251/streptococcus-pneumoniae-induced-ototoxicity-in-organ-of-corti-explant-cultures
#16
Michael Perny, Magdalena Solyga, Denis Grandgirard, Marta Roccio, Stephen L Leib, Pascal Senn
Hearing loss remains the most common long-term complication of pneumococcal meningitis (PM) reported in up to 30% of survivors. Streptococcus pneumoniae have been shown to possess different ototoxic properties. Here we present a novel ex vivo experimental setup to examine in detail the pattern of hair cell loss upon exposure to different S. pneumoniae strains, therefore recapitulating pathogen derived aspects of PM-induced hearing loss. Our results show a higher susceptibility towards S. pneumoniae-induced cochlear damage for outer hair cells (OHC) compared to inner hair cells (IHC), which is consistent with in vivo data...
April 25, 2017: Hearing Research
https://www.readbyqxmd.com/read/28453904/genetics-and-other-factors-in-the-aetiology-of-female-pattern-hair-loss
#17
REVIEW
Silke Redler, Andrew G Messenger, Regina C Betz
Pattern hair loss is the most common form of hair loss in both women and men. Male pattern hair loss, also termed male androgenetic alopecia (M-AGA), is an androgen-dependent trait that is predominantly genetically determined. Androgen-mediated mechanisms are probably involved in FPHL in some women but the evidence is less strong than in M-AGA; and other non-androgenic pathways, including environmental influences, may contribute to the aetiology. Genome-wide association studies (GWASs) have identified several genetic loci for M-AGA and have provided better insight into the underlying biology...
April 28, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28438658/antioxidants-reduce-neurodegeneration-and-accumulation-of-pathologic-tau-proteins-in-the-auditory-system-after-blast-exposure
#18
Xiaoping Du, Matthew B West, Qunfeng Cai, Weihua Cheng, Donald L Ewert, Wei Li, Robert A Floyd, Richard D Kopke
Cochlear neurodegeneration commonly accompanies hair cell loss resulting from aging, ototoxicity, or exposures to intense noise or blast overpressures. However, the precise pathophysiological mechanisms that drive this degenerative response have not been fully elucidated. Our laboratory previously demonstrated that non-transgenic rats exposed to blast overpressures exhibited marked somatic accumulation of neurotoxic variants of the microtubule-associated protein, Tau, in the hippocampus. In the present study, we extended these analyses to examine neurodegeneration and pathologic Tau accumulation in the auditory system in response to blast exposure and evaluated the potential therapeutic efficacy of antioxidants on short-circuiting this pathological process...
April 22, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28436024/hair-diameter-evaluation-in-different-regions-of-the-safe-donor-area-in-asian-populations
#19
Jae H Park, Jae M Park, Na R Kim, Kotchamol Manonukul
BACKGROUND: There is little information about how hair diameter differences within the safe donor area. Thicker or thinner hair may be needed depending on the recipient area, hairline design, and surgical purpose. METHODS: Thirty-eight non-alopecic subjects (19 males and 19 females) were evaluated. The safe donor area was defined as the area contained within 28 cm from the horizontal plane of the upper border of the hair rim to the vertical line of the bilateral external acoustic meatus...
July 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28432872/human-effector-memory-t-helper-cells-engage-with-mouse-macrophages-and-cause-graft-versus-host-like-pathology-in-skin-of-humanized-mice-used-in-a-nonclinical-immunization-study
#20
Balasai Sundarasetty, Valery Volk, Sebastian J Theobald, Susanne Rittinghausen, Dirk Schaudien, Vanessa Neuhaus, Constanca Figueiredo, Andreas Schneider, Laura Gerasch, Adele Mucci, Thomas Moritz, Constantin von Kaisenberg, Loukia M Spineli, Katherina Sewald, Armin Braun, Henning Weigt, Arnold Ganser, Renata Stripecke
Humanized mice engrafted with human hematopoietic stem cells and developing functional human T-cell adaptive responses are in critical demand to test human-specific therapeutics. We previously showed that humanized mice immunized with long-lived induced-dendritic cells loaded with the pp65 viral antigen (iDCpp65) exhibited a faster development and maturation of T cells. Herein, we evaluated these effects in a long-term (36 weeks) nonclinical model using two stem cell donors to assess efficacy and safety. Relative to baseline, iDCpp65 immunization boosted the output of effector memory CD4(+) T cells in peripheral blood and lymph nodes...
June 2017: American Journal of Pathology
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