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Poli l latic acid

Yanchun Liu, Tyler Nelson, Barrett Cromeens, Terrence Rager, John Lannutti, Jed Johnson, Gail E Besner
The ability to deliver sustained-release, biologically active growth factors through custom designed tissue engineering scaffolds at sites of tissue regeneration offers great therapeutic opportunity. Due to the short in vivo half-lives of most growth factors, it is challenging to deliver these proteins to sites of interest where they may be used before being degraded. The application of subcritical CO2 uses gas-phase CO2 at subcritical pressures ranging from 41 to 62 bar (595-913 PSI) which avoids foaming by reducing the amount of CO2 dissolved in the polymer and maintains completely reversible plasticization...
October 2016: Biomaterials
Weiwei Zheng, Min Yang, Cheng Wu, Xianlin Su
OBJECTIVE: To investigate the osteogenic differentiation potential and the biological features of synovium-derived mesenchymal stem cells (SMSCs) in vitro and to observe the osteogenic capability of the composite scaffolds constructed with SMSCs and hydroxylapatite/chitosan/poly L-latic acid (HA/CS/PLLA) in vivo. METHODS: SMSCs were separated and cultured with adherent method and enzymatic digestion method. Specific phenotypes of SMSCs were detected by flow cytometry after purification...
January 2016: Chinese Journal of Reparative and Reconstructive Surgery
C V Leal, D S T Martinez, B A Más, O L Alves, E A R Duek
Poly (L-latic acid) (PLLA) is a bioresorbable polymer widely used as a biomaterial, but its fragility can limit its use. An alternative is to produce polymer nanocomposites, which can enhance the mechanical properties of polymeric matrix, resulting in a material with differentiated properties. In this work, PLLA based nanocomposites containing 0.25, 0.5 and 1.0wt% of purified multiwalled carbon nanotubes (p-MWCNTs) were prepared by the solvent casting method. The morphology and mechanical properties results show an improvement in strain at break for 0...
June 2016: Journal of the Mechanical Behavior of Biomedical Materials
Rhoda S Narins
BACKGROUND Injectable devices offer an attractive alternative to surgical cosmetic rejuvenation. Many injectable products are biocompatible but demonstrate varying levels of durability, ranging from temporary to permanent. Product duration is determined, in part, by its mode of operation. Passive fillers, such as collagen, generally add volume through mass, whereas other injectables, such as poly-L-latic acid (PLLA), rely on a foreign-body response in which endogenous collagen production by fibroblasts is thought to generate new volume...
June 2008: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Guangyao Liu, Hiroshi Kawaguchi, Toru Ogasawara, Yukiyo Asawa, Junji Kishimoto, Tsuguharu Takahashi, Ung-Il Chung, Hisayo Yamaoka, Hirotaka Asato, Kozo Nakamura, Tsuyoshi Takato, Kazuto Hoshi
Since permanent cartilage has poor self-regenerative capacity, its regeneration from autologous human chondrocytes using a tissue engineering technique may greatly benefit the treatment of various skeletal disorders. However, the conventional autologous chondrocyte implantation is insufficient both in quantity and in quality due to two major limitations: dedifferentiation during a long term culture for multiplication and hypertrophic differentiation by stimulation for the redifferentiation. To overcome the limitations, this study attempted to determine the optimal combination in primary human chondrocyte cultures under a serum-free condition, from among 12 putative chondrocyte regulators...
July 13, 2007: Journal of Biological Chemistry
Eduardo Ricci-Júnior, Juliana Maldonado Marchetti
Sophisticated delivery systems, such as nanoparticles, represent a growing area in biomedical research. Nanoparticles (Np) were prepared using a solvent emulsion evaporation method (SEEM) to load zinc(II) phthalocyanine (ZnPc). Np were obtained using poly (D,L latic-co-glycolic acid) (PLGA). ZnPc is a second generation of photoactive agents used in photodynamic therapy. ZnPc loaded PLGA nanoparticles were prepared by SEEM, characterized and available in cellular culture. The process yield and encapsulation efficiency were 80 and 70%, respectively...
March 9, 2006: International Journal of Pharmaceutics
T Reihs, M Müller, K Lunkwitz
We report on bulk and surface properties of centrifuged nonstoichiometric polyelectrolyte complex (PEC) dispersions. PECs were prepared by mixing poly(diallyldimethylammonium chloride) (PDADMAC) and sodium poly(maleic acid-co-alpha-methylstyrene) (PMA-MS) at the monomolar mixing ratio of 0.6 and polymer concentration >/=1 mmol/l. Centrifugation of initial PEC dispersions revealed three phases: supernatant (SUP), coacervate (COAC), and an insoluble precipitate. Mass, turbidity, particle hydrodynamic radii (R(h)), and the titratable charge amount were determined for those phases...
March 1, 2004: Journal of Colloid and Interface Science
A Westermark
Twenty patients had sagittal split osteosynthesis performed with three or four 2.5-mm resorbable screws on each side without additional fixation. The screws consisted of a poly-L-latic/polyglycolic copolymer (LactoSorb). Of the 20 patients, 17 had mandibular advancement, two had mandibular setback, and one underwent unilateral mandibular advancement after previous condylectomy. Six patients underwent simultaneous Le Fort I osteotomy and four patients had simultaneous genioplasty. Postoperative training elastics were maintained for an average of 2...
November 1999: Journal of Craniofacial Surgery
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