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Henry Paul Redmond

Michael Ita, Kevin Koh, Abeeda Butt, Shaheed KaimKhani, Louise Kelly, Martin J O'Sullivan, Henry Paul Redmond, Mark A Corrigan
BACKGROUND: Cosmetic outcomes and scar lengths remain important considerations in breast cancer surgery. Suturing techniques should decrease scar tissue formation and provide good cosmetic results. The use of an accordion suturing technique may result in decreased surgical wound lengths and better cosmetic outcomes. We compared the outcomes of the accordion suturing technique with the standard suturing technique in breast cancer surgeries. MATERIALS AND METHODS: Female patients undergoing wide local excision of breast cancers were randomised to undergo closure of their surgical wound by either the accordion or the non-accordion (standard) suturing techniques between the months of May and October 2015...
March 21, 2018: Irish Journal of Medical Science
Asad Ali Toor, Muhammad Waris Farooka, Mahmood Ayyaz, Zeeshan Razzaq, Awais Amjad Malik, Allah Nawaz, Asif Mahmood, Henry Paul Redmond
BACKGROUND: Morbid obesity has become a surgically treatable problem. Laparoscopic sleeve gastrectomy is becoming a popular choice both for surgeons and patients due to effectiveness and low complication rates. METHODS: It was a prospective case series spanning over 6 years. Patient enrolment started from January 2009 and data collection completed in January 2015. Patient with BMI (weight in kilogram/height in meter square) of more than 35 were included in the study...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
Louise E Daly, Derek G Power, Áine O'Reilly, Paul Donnellan, Samantha J Cushen, Kathleen O'Sullivan, Maria Twomey, David P Woodlock, Henry P Redmond, Aoife M Ryan
BACKGROUND: Body composition is an important predictor of drug toxicity and outcome. Ipilimumab (Ipi), a monoclonal antibody used to treat metastatic melanoma, has specific toxicities. No validated biomarkers that predict Ipi toxicity and efficacy exist. Also, the impact of Ipi on body composition has not been established. METHODS: Patients with metastatic melanoma treated with Ipi between 2009 and 2015 were included. Body composition was assessed by computed tomography at baseline and after four cycles of Ipi...
January 2017: British Journal of Cancer
Henry Zhao, Henry M Marshall, Ian A Yang, Rayleen V Bowman, John Ayres, Jane Crossin, Melanie Lau, Richard E Slaughter, Stanley Redmond, Linda Passmore, Elizabeth McCaul, Deborah Courtney, Steven C Leong, Morgan Windsor, Paul V Zimmerman, Kwun M Fong
OBJECTIVE: To report the long-term follow-up of subsolid nodules (SSNs) detected in participants of a prospective low-dose CT lung cancer screening cohort, and to investigate the utility of the PanCan model in stratifying risk in baseline SSNs. METHODS: Participants underwent a baseline scan, two annual incidence scans and further follow-up scans for the detected nodules. All SSNs underwent a minimum of 2 years of follow-up (unless resolved or resected). Risk of malignancy was estimated using the PanCan model; discrimination [area under the receiver-operating characteristic curve (AUC)] and calibration (Hosmer-Lemeshow goodness-of-fit test) were assessed...
2016: British Journal of Radiology
Edel Marie Quinn, Peter Cantillon, Henry Paul Redmond, Deirdre Bennett
BACKGROUND: Journal club has become a signature pedagogy in postgraduate medical education. In this article, social learning theory, through the lens of "communities of practice" (CoP), is applied to elucidate the process of learning in journal club. MATERIALS AND METHODS: The study is a case study of a surgical journal club. Video recordings of 2 journal club sessions were followed by semistructured audio-recorded interviews with a sample of journal club participants...
July 2014: Journal of Surgical Education
Edel Marie Quinn, Mark A Corrigan, John O'Mullane, David Murphy, Elaine A Lehane, Patricia Leahy-Warren, Alice Coffey, Patricia McCluskey, Henry Paul Redmond, Greg J Fulton
BACKGROUND: Chronic ulcers affect roughly 60,000 Irish people, at a total cost of €600,000,000, or €10,000 per patient annually. By virtue of their chronicity, these ulcers also contribute a significant burden to tertiary outpatient vascular clinics. OBJECTIVE: We propose utilizing mobile phone technology to decentralise care from tertiary centres to the community, improving efficiency and patient satisfaction, while maintaining patient safety. METHODS: Bespoke mobile software was developed for Apples iPhone 4 platform...
2013: PloS One
Edel M Quinn, Mark A Corrigan, Seamus M McHugh, David Murphy, John O'Mullane, Arnold D Hill, Henry Paul Redmond
OBJECTIVE: Breast cancer is the cancer most commonly searched for on the internet. Our aim was to assess daily new breast cancer related posting on the internet. METHODS: We analyzed numbers of new daily posts for common cancers for one month and subsequently analyzed content of 1426 breast cancer related posts. We also assessed use of online discussion forums for breast cancer related dialogue. RESULTS: Breast related topics had significantly more posts per day compared to others (mean 66...
February 2013: Breast: Official Journal of the European Society of Mastology
Edel Marie Quinn, Andrew Peter Coveney, Henry Paul Redmond
BACKGROUND: Diagnosis of breast cancer recurrence can be difficult as a result of the presence of scar tissue in the breast. Magnetic resonance imaging (MRI) may be superior to traditional imaging in diagnosis of recurrence because of its ability to differentiate malignancy from scarring. Current guidelines on investigation of suspected breast cancer recurrence recommend MRI when other investigations have equivocal findings. We performed the first systematic review on this topic. METHODS: Literature search revealed 35 potentially relevant studies; 10 were included in final analysis...
September 2012: Annals of Surgical Oncology
Edel Marie Quinn, David E Kearney, Justin Kelly, Catherine Keohane, Henry Paul Redmond
BACKGROUND: Temporal artery biopsy (TAB) is performed during the diagnostic workup for giant cell arteritis (GCA), a vasculitis with the potential to cause irreversible blindness or stroke. However, treatment is often started on clinical grounds, and TAB result frequently does not influence patient management. The aim of this study was to assess the need for TAB in cases of suspected GCA. METHODS: We performed a retrospective review of 185 TABs performed in our institution from 1990 to 2010...
July 2012: Annals of Vascular Surgery
John Calvin Coffey, Eoghan McCarthy, Eamon Kavanagh, Henry Paul Redmond, William Oliver Kirwan
While the overall incidence of pouchitis is low, extensive research continues at clinical and experimental levels in attempts to unravel its etiology. The ileal pouch and pouchitis together represent a unique in vivo opportunity to study mucosal adaptation and inflammation in depth. In the recent past, molecular data relating to pouchitis has significantly expanded. These data provide invaluable insight into intracellular and extracellular events that underpin mucosal adaptation and inflammation. Advances in classification, risk factor evaluation, and prevention have meant that a review of this data, as well as its relationship to our current understanding of pouchitis, is both timely and warranted...
January 2009: Diseases of the Colon and Rectum
Hilary Hurley, Ronan A Cahill, Paul Ryan, Ashraf I Morcos, Henry P Redmond, Helen M Kiely
We report here how a heterotopic penetrating peptic ulcer progressed to cause small bowel obstruction in a patient with multiple previous negative investigations. The clinical presentation, radiographic features and pathological findings of this case are described, along with the salient lessons learnt. The added value of wireless capsule endoscopy (WCE) in such circumstances is debated.
December 14, 2007: World Journal of Gastroenterology: WJG
Mark Corrigan, Ronan A Cahill, Henry Paul Redmond
Laparoscopic alternatives to conventional surgical procedures confer many advantages to patients including reduced postoperative pain, shortened convalescence and, perhaps, improved disease-related outcomes. The diminished degree of immune dysfunction apparent with these techniques may underpin these beneficial aspects. However, minimal access is accompanied by various ancillary anesthetic and mechanical associations (including the induction of a carbon dioxide pneumoperitoneum), which must be considered in addition to reduced tissue trauma when attempting to correlate cause with effect...
August 2007: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
Mahmood Alam, Jiang Huai Wang, John Calvin Coffey, Syed Suhail Qadri, Aonghus O'Donnell, Thomas Aherne, Henry Paul Redmond
BACKGROUND: Cyclooxygenase-2 enzyme (COX-2) is overexpressed in human non-small cell lung cancer (NSCLC) but is not expressed in small cell lung cancer. Selective COX-2 inhibitors have been shown to induce apoptosis in NSCLC cells, an effect which is associated with the regulation of intracellular MAP kinase (MAPK) signal pathways. Our aims were to characterize the effects of COX-2 inhibition by rofecoxib on apoptosis in human NSCLC and small cell lung cancer cell lines. METHODS: The human NSCLC cell line NCI-H2126 and small cell lung cancer cell line DMS-79 were used...
September 2007: Annals of Surgical Oncology
Laszlo Romics, Gyongyi Szabo, John Calvin Coffey, Jiang Huai Wang, Henry Paul Redmond
OBJECTIVE: To outline the emerging significance of Toll-like receptor (TLR) signaling pathways in surgical diseases. DATA SOURCES: A systematic review of the literature was undertaken by searching the MEDLINE database for the period 1966 to 2005 without language restriction. STUDY SELECTION: Original or review articles that described experimental data on the activation of TLR signaling pathways in surgically relevant diseases were selected for inclusion in this review...
June 2006: Archives of Surgery
Liam O'Mahony, Louise O'Callaghan, Jane McCarthy, David Shilling, Paul Scully, Shomik Sibartie, Eamon Kavanagh, William O Kirwan, Henry Paul Redmond, John Kevin Collins, Fergus Shanahan
Resident host microflora condition and prime the immune system. However, systemic and mucosal immune responses to bacteria may be divergent. Our aim was to compare, in vitro, cytokine production by human mononuclear and dendritic cells (DCs) from mesenteric lymph nodes (MLNs) and peripheral blood mononuclear cells (PBMCs) to defined microbial stimuli. Mononuclear cells and DCs isolated from the MLN (n = 10) and peripheral blood (n = 12) of patients with active colitis were incubated in vitro with the probiotic bacteria Lactobacillus salivarius UCC118 or Bifidobacterium infantis 35624 or the pathogenic organism Salmonella typhimurium UK1...
April 2006: American Journal of Physiology. Gastrointestinal and Liver Physiology
László Romics, John Calvin Coffey, Jiang Huai Wang, Henry Paul Redmond, Gyöngyi Szabó
The discovery of Toll-like receptors has substantially changed our knowledge of pathogen recognition. 11 Toll-like receptors have so far been described in humans. These recognize distinct pathogen associated molecular patterns, as well as endogenous ligands and small molecular synthetic compounds. TLRs have a multifunctional role in pathogen-triggered immune responses and represent an important connection between the "innate" and "adaptive" immunity. The role of the TLRs in the recognition of pathogens renders them a key figure in the activation of the immune response during surgical sepsis...
August 2004: Magyar Sebészet
Claire Condron, Paul Neary, Deirdre Toomey, Henry Paul Redmond, David Bouchier-Hayes
The pathway involved in Fas-mediated neutrophil apoptosis remains to be fully elucidated. We examined whether this pathway involved either oxygen-dependent or calcium-dependent mechanisms. We also investigated whether taurine, a powerful antioxidant and regulator of intracellular calcium fluxes, could inhibit Fas-mediated neutrophil apoptosis. Neutrophils were stimulated with Fas monoclonal antibody in the presence or absence of taurine. Fas receptor ligation resulted in significant neutrophil apoptosis at 18 h...
June 2003: Shock
Syed Suhail Ahmed Qadri, Jiag Huai Wang, Karen Christina Redmond, Aonghus F O' Donnell, Thomas Aherne, Henry Paul Redmond
BACKGROUND: Human lung cancer is a major cause of death worldwide with few known effective therapeutic modalities. The isoenzyme cyclooxygenase 2 (COX-2) is an inducible inflammatory enzyme with increased activity evidenced in lung carcinoma. The objective was to determine the effect of a selective COX-2 inhibitor on proliferation and apoptosis rates in the Lewis lung (3LL) tumor cell line in vitro. METHODS: First, 1 x 10(4) 3LL cells were plated in a 96-well plate...
November 2002: Annals of Thoracic Surgery
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