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JOURNAL ARTICLE
Fara Hassan, Jiang Huai Wang, Donal Peter O'Leary, Mark Corrigan, Henry Paul Redmond
BACKGROUND: Circulating tumour DNA (ctDNA), contains tumour-specific gene mutation in blood circulation and could aid in postoperative risk stratification of non-metastatic breast cancer. In this study, we investigated the feasibility of detecting PIK3CA gene mutations in ctDNA in the preoperative (preop) and postoperative period (postop), and its prognostic significance in patients with breast cancer. METHODS: A cohort of patients with breast cancer undergoing curative surgery with available blood samples preoperatively and postoperatively (Post op) at either Post op time period; week 1-2, week 3-4 or weeks 5-12 were enrolled...
March 5, 2024: Surgical Oncology
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JOURNAL ARTICLE
Rosalie B T M Sterenborg, Inga Steinbrenner, Yong Li, Melissa N Bujnis, Tatsuhiko Naito, Eirini Marouli, Tessel E Galesloot, Oladapo Babajide, Laura Andreasen, Arne Astrup, Bjørn Olav Åsvold, Stefania Bandinelli, Marian Beekman, John P Beilby, Jette Bork-Jensen, Thibaud Boutin, Jennifer A Brody, Suzanne J Brown, Ben Brumpton, Purdey J Campbell, Anne R Cappola, Graziano Ceresini, Layal Chaker, Daniel I Chasman, Maria Pina Concas, Rodrigo Coutinho de Almeida, Simone M Cross, Francesco Cucca, Ian J Deary, Alisa Devedzic Kjaergaard, Justin B Echouffo Tcheugui, Christina Ellervik, Johan G Eriksson, Luigi Ferrucci, Jan Freudenberg, Christian Fuchsberger, Christian Gieger, Franco Giulianini, Martin Gögele, Sarah E Graham, Niels Grarup, Ivana Gunjača, Torben Hansen, Barbara N Harding, Sarah E Harris, Stig Haunsø, Caroline Hayward, Jennie Hui, Till Ittermann, J Wouter Jukema, Eero Kajantie, Jørgen K Kanters, Line L Kårhus, Lambertus A L M Kiemeney, Margreet Kloppenburg, Brigitte Kühnel, Jari Lahti, Claudia Langenberg, Bruno Lapauw, Graham Leese, Shuo Li, David C M Liewald, Allan Linneberg, Jesus V T Lominchar, Jian'an Luan, Nicholas G Martin, Antonela Matana, Marcel E Meima, Thomas Meitinger, Ingrid Meulenbelt, Braxton D Mitchell, Line T Møllehave, Samia Mora, Silvia Naitza, Matthias Nauck, Romana T Netea-Maier, Raymond Noordam, Casia Nursyifa, Yukinori Okada, Stefano Onano, Areti Papadopoulou, Colin N A Palmer, Cristian Pattaro, Oluf Pedersen, Annette Peters, Maik Pietzner, Ozren Polašek, Peter P Pramstaller, Bruce M Psaty, Ante Punda, Debashree Ray, Paul Redmond, J Brent Richards, Paul M Ridker, Tom C Russ, Kathleen A Ryan, Morten Salling Olesen, Ulla T Schultheiss, Elizabeth Selvin, Moneeza K Siddiqui, Carlo Sidore, P Eline Slagboom, Thorkild I A Sørensen, Enrique Soto-Pedre, Tim D Spector, Beatrice Spedicati, Sundararajan Srinivasan, John M Starr, David J Stott, Toshiko Tanaka, Vesela Torlak, Stella Trompet, Johanna Tuhkanen, André G Uitterlinden, Erik B van den Akker, Tibbert van den Eynde, Melanie M van der Klauw, Diana van Heemst, Charlotte Verroken, W Edward Visser, Dina Vojinovic, Henry Völzke, Melanie Waldenberger, John P Walsh, Nicholas J Wareham, Stefan Weiss, Cristen J Willer, Scott G Wilson, Bruce H R Wolffenbuttel, Hanneke J C M Wouters, Margaret J Wright, Qiong Yang, Tatijana Zemunik, Wei Zhou, Gu Zhu, Sebastian Zöllner, Johannes W A Smit, Robin P Peeters, Anna Köttgen, Alexander Teumer, Marco Medici
To date only a fraction of the genetic footprint of thyroid function has been clarified. We report a genome-wide association study meta-analysis of thyroid function in up to 271,040 individuals of European ancestry, including reference range thyrotropin (TSH), free thyroxine (FT4), free and total triiodothyronine (T3), proxies for metabolism (T3/FT4 ratio) as well as dichotomized high and low TSH levels. We revealed 259 independent significant associations for TSH (61% novel), 85 for FT4 (67% novel), and 62 novel signals for the T3 related traits...
January 30, 2024: Nature Communications
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JOURNAL ARTICLE
Adrienne Tin, Alison E Fohner, Qiong Yang, Jennifer A Brody, Gail Davies, Jie Yao, Dan Liu, Ilana Caro, Joni V Lindbohm, Michael R Duggan, Osorio Meirelles, Sarah E Harris, Valborg Gudmundsdottir, Adele M Taylor, Albert Henry, Alexa S Beiser, Ali Shojaie, Annabell Coors, Annette L Fitzpatrick, Claudia Langenberg, Claudia L Satizabal, Colleen M Sitlani, Eleanor Wheeler, Elliot M Tucker-Drob, Jan Bressler, Josef Coresh, Joshua C Bis, Julián Candia, Lori L Jennings, Maik Pietzner, Mark Lathrop, Oscar L Lopez, Paul Redmond, Robert E Gerszten, Stephen S Rich, Susan R Heckbert, Thomas R Austin, Timothy M Hughes, Toshiko Tanaka, Valur Emilsson, Ramachandran S Vasan, Xiuqing Guo, Yineng Zhu, Christophe Tzourio, Jerome I Rotter, Keenan A Walker, Luigi Ferrucci, Mika Kivimäki, Monique M B Breteler, Simon R Cox, Stephanie Debette, Thomas H Mosley, Vilmundur G Gudnason, Lenore J Launer, Bruce M Psaty, Sudha Seshadri, Myriam Fornage
Identifying circulating proteins associated with cognitive function may point to biomarkers and molecular process of cognitive impairment. Few studies have investigated the association between circulating proteins and cognitive function. We identify 246 protein measures quantified by the SomaScan assay as associated with cognitive function (p < 4.9E-5, n up to 7289). Of these, 45 were replicated using SomaScan data, and three were replicated using Olink data at Bonferroni-corrected significance...
November 3, 2023: Communications Biology
#4
REVIEW
Martyna Bakierzynska, Ms Carolyn Cullinane, Henry Paul Redmond, Mark Corrigan
Breast Cancer (BC) is the most common cancer amongst women. The chemo-preventative effects of aspirin on breast cancer have been demonstrated in several longitudinal studies however previous meta-analysis have shown inconsistent results. This study aimed to assess the relationship between aspirin use and BC risk, and to determine if there is a dose-response relationship between aspirin and BC risk. Studies incorporating BC risk with aspirin use published within the last twenty years were included. The study report is based on the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) and Meta-Analysis of Observational Studies in Epidemiology...
October 2023: European Journal of Surgical Oncology
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JOURNAL ARTICLE
Jim Byrne, Samuel Keogh, Carolyn Cullinane, Zeeshan Razzaq, Henry Paul Redmond
Objective: Assessment of the readability and quality of online health information regarding parathyroidectomy. Study Design: Cross-sectional analysis. Setting: Websites providing patient-oriented health information regarding parathyroidectomy obtained via the Google search engine. Methods: The top 75 Google search results for "parathyroidectomy,""parathyroid surgery," and "parathyroid gland removal" were reviewed. Websites were categorized by website type and country of origin...
October 2022: OTO Open
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JOURNAL ARTICLE
Fara Hassan, Jiang Huai Wang, Carolyn Cullinane, Michael Ita, Mark Corrigan, Donal Peter O'Leary, Henry Paul Redmond
BACKGROUND: Circulating cell-free DNA (cfDNA) is a potential non-invasive biomarker of disease status in patients with cancer, and provides important diagnostic and prognostic information in breast cancer. The goal of this study was to quantify cfDNA concentrations during the perioperative period and investigate its potential utility to detect recurrence outcomes in patients with breast cancer. METHODS: Sixty-two (n = 62) patients with non-metastatic breast cancer, undergoing curative-intent surgery were screened for inclusion...
April 3, 2022: Surgical Oncology
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REVIEW
Carolyn Cullinane, James Byrne, Louise Kelly, Martin O Sullivan, Mark Antony Corrigan, Henry Paul Redmond
INTRODUCTION: High-risk or B3 breast lesions are considered lesions of uncertain malignant potential and comprise between 5 and 12% of initial biopsy results. We sought to perform a systematic review and meta-analysis of studies published within the last twenty years to determine the pooled Positive Predictive Value (PPV) of VAB in selected B3 lesions. METHODS: The study report is based on the guidelines of PRISMA and Meta-Analysis of Observational Studies in Epidemiology...
July 2022: European Journal of Surgical Oncology
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JOURNAL ARTICLE
Raphaela Fritsche-Guenther, Yoann Gloaguen, Anna Bauer, Tobias Opialla, Stefan Kempa, Christina A Fleming, Henry Paul Redmond, Jennifer A Kirwan
Using manual derivatization in gas chromatography-mass spectrometry samples have varying equilibration times before analysis which increases technical variability and limits the number of potential samples analyzed. By contrast, automated derivatization methods can derivatize and inject each sample in an identical manner. We present a fully automated (on-line) derivatization method used for targeted analysis of different matrices. We describe method optimization and compare results from using off-line and on-line derivatization protocols, including the robustness and reproducibility of the methods...
December 18, 2021: Metabolites
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JOURNAL ARTICLE
Michael Itak Ita, Jiang Huai Wang, André Toulouse, Chris Lim, Noel Fanning, Michael O'Sullivan, Yvonne Nolan, George Finbarr Kaar, Henry Paul Redmond
BACKGROUND: Research into the potential utility of plasma-derived circulating cell-free nucleic acids as non-invasive adjuncts to radiological imaging have been occasioned by the invasive nature of brain tumour biopsy. The objective of this study was to determine whether significant differences exist in the plasma transcriptomic profile of glioma patients relative to differences in their tumour characteristics, and also whether any observed differences were representative of synchronously obtained glioma samples and TCGA glioma-derived RNA...
March 2022: Acta Neurochirurgica
#10
REVIEW
Patrick R Jordan, Donal Peter O'Leary, Cristina A Fleming, Jianghuai Wang, Henry Paul Redmond
BACKGROUND: Liquid biopsy is gaining increasing clinical utility in the management of cancer patients. The main components of a liquid biopsy are circulating nucleic acids, circulating tumour cells and extracellular vesicles such as exosomes. Circulating nucleic acids including cell free DNA (cfDNA) and circulating tumour DNA (ctDNA) in particular have been the focus of recent attention as they have demonstrated excellent potential in cancer screening, provision of prognostic information and in genomic profiling of a tumour without the need for repeated tissue biopsies...
August 3, 2021: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
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JOURNAL ARTICLE
Orla A Houlihan, Richard Moore, Muhammad F Jamaluddin, Adrinda Sharifah, Henry Paul Redmond, Seamus O'Reilly, Linda Feeley, Patrick Sheahan, Kathy Rock
Backround: The purpose of this study is to assess the impact of trimodal therapy [surgery, chemotherapy and external beam radiotherapy (EBRT)] in patients with anaplastic thyroid cancer (ATC) treated with curative intent. Materials and methods: Retrospective review of patients with ATC treated at a tertiary referral centre between January 2009 and June 2020. Data were collected regarding demographics, histology, staging, treatment and outcomes. Results: Seven patients (4 female) were identified...
2021: Reports of Practical Oncology and Radiotherapy
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JOURNAL ARTICLE
Michael Itak Ita, Jiang Huai Wang, Noel Fanning, George Kaar, Chris Lim, Henry Paul Redmond
BACKGROUND: Blood borne cell free nucleic acids are increasingly emerging as significant non-invasive adjuncts to current methods of disease status evaluation in cancer patients. In this study, we sought to examine whether significant differences exist in the plasma transcriptomic profile of advanced melanoma patients with a high disease burden compared to patients with a low disease burden or therapeutic response. METHODS: Pathway focussed gene expression analysis was performed using cDNA derived from the plasma circulating cell free messenger ribonucleic acid (ccfmRNA) samples of twenty-two patients with advanced melanoma...
September 2021: Acta Oncologica
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JOURNAL ARTICLE
Carolyn Cullinane, Christina Fleming, Donal Peter O'Leary, Fara Hassan, Louise Kelly, Martin J O'Sullivan, Mark Antony Corrigan, Henry Paul Redmond
Importance: Fragmented DNA is continuously released into the circulation following apoptosis and necrosis of both cancerous and noncancerous cells; when it is released by cancer cells, it is specifically known as circulating tumor DNA (ctDNA). Previous studies have suggested that ctDNA can reflect tumor burden and guide potential therapeutic targets. Objective: To determine the association of ctDNA with breast cancer disease-free survival (DFS) and progression-free survival in early, locally advanced, and metastatic breast cancer...
November 2, 2020: JAMA Network Open
#14
JOURNAL ARTICLE
Lisa Christine Murphy, Edel Marie Quinn, Zeeshan Razzaq, Claire Brady, Vicki Livingstone, Lorna Duddy, Josephine Barry, Henry Paul Redmond, Mark Anthony Corrigan
Management of the axilla in the era of neoadjuvant chemotherapy for breast cancer is evolving. The aim of this study is to determine if conventional gadolinium-enhanced breast MRI can aid in evaluation of the response to neoadjuvant chemotherapy in the axilla. A retrospective review of a prospectively maintained database of patients undergoing neoadjuvant chemotherapy for breast cancer was performed. Pre and post-neoadjuvant chemotherapy MRI reports for node-positive patients were examined in conjunction with demographic data, treatment type, and final histopathology reports...
November 2020: Breast Journal
#15
JOURNAL ARTICLE
Carolyn M Cullinane, James Byrne, Liga Akmenkalne, Donal P O' Leary, Alissa M Connors, Mark A Corrigan, Henry Paul Redmond, Louise Kelly, Martin J O' Sullivan
Background. Breast screening has decreased morbidity and mortality due to detection of early, non-palpable breast cancers. One of the challenges of performing breast-conserving surgery on non-palpable breast tumours is accurate localization of the cancer. We aimed to perform a feasibility study to examine the outcomes associated with the introduction of a novel radiofrequency identification system (RFID) called LOCalizer as an alternative to traditional wire-guided localization. Methods. Data were prospectively collected on all patients undergoing breast-conserving surgery using the LOCalizer RFID system in a regional cancer centre between July 2019 and March 2020...
October 21, 2020: Surgical Innovation
#16
REVIEW
Carolyn Cullinane, Ben Creavin, Donal Peter O'Leary, Martin J O'Sullivan, Louise Kelly, Henry Paul Redmond, Mark Antony Corrigan
The systemic inflammatory response plays a role in tumor progression and development. The neutrophil to lymphocyte ratio (NLR) is a biochemical marker of systemic inflammation and is increasingly gaining appreciation for its prognostic role in predicting breast cancer outcomes. Previous research has demonstrated that patients who achieve a complete pathologic response (pCR) to neoadjuvant breast cancer treatment have a more favorable disease-free survival. This study aimed to assess whether the NLR can predict pCR to neoadjuvant therapy in breast cancer...
December 2020: Clinical Breast Cancer
#17
JOURNAL ARTICLE
Carlos Sánchez Belmar, Alexandra White, Mudassar Majeed, Henry Paul Redmond
An unusual presentation of sclerosing angiomatoid nodular transformation in a 42-year-old man who was admitted with jaundice, deranged liver function tests and subsequently diagnosed with acute hepatitis C infection in the context of recent intravenous drug use. During his admission, he had an ultrasound of the abdomen followed by a CT thorax, abdomen and pelvis which showed splenomegaly and a large splenic lower pole mass that was hypoechoic and concerning for lymphoma. A bone marrow biopsy showed no evidence of lymphoma and an ultrasound-guided biopsy of the splenic mass suggested unusual features with vascular proliferation, either neoplastic or reactive, with no evidence of lymphoma or high-grade sarcoma...
June 21, 2020: BMJ Case Reports
#18
JOURNAL ARTICLE
David Cagney, Michael Hanrahan, Zeeshan Razzaq, Mudassar Majeed, Donal Peter O'Leary, Henry Paul Redmond
BACKGROUND: Laparoscopic transperitoneal and retroperitoneoscopic adrenalectomy have largely replaced open adrenal surgery, particularly in benign disease. Laparoscopic surgery results in less post-operative pain, fewer surgical site complications and reduced length of hospital stay. The aim of this retrospective study was to analyse the characteristics of patients and evolution of surgical technique in adrenal surgery at Cork University Hospital over a 12-year period. METHODS: All cases of adrenalectomy between January 1st, 2007 and December 31st, 2018 were retrospectively reviewed...
March 5, 2020: Irish Journal of Medical Science
#19
JOURNAL ARTICLE
David Cagney, Lydia Simmons, Donal Peter O'Leary, Mark Corrigan, Louise Kelly, M J O'Sullivan, Aaron Liew, Henry Paul Redmond
BACKGROUND: Negative pressure wound therapy (NPWT) is a promising advance in the management of closed surgical incisions. NPWT application induces several effects locally within the wound including reduced lateral tension and improving lymphatic drainage. As a result, NPWT may improve wound healing and reduce surgical site complications. We aim to evaluate the efficacy of prophylactic application of NPWT in preventing surgical site complications for closed incisions in breast surgery...
May 2020: World Journal of Surgery
#20
JOURNAL ARTICLE
Christina A Fleming, Donal Peter O'Leary, Jianghuai Wang, Henry Paul Redmond
No abstract text is available yet for this article.
December 4, 2019: JAMA Surgery
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