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JOURNAL ARTICLE
Fara Hassan, Jiang Huai Wang, Donal Peter O'Leary, Mark Corrigan, Henry Paul Redmond
BACKGROUND: Circulating tumour DNA (ctDNA), contains tumour-specific gene mutation in blood circulation and could aid in postoperative risk stratification of non-metastatic breast cancer. In this study, we investigated the feasibility of detecting PIK3CA gene mutations in ctDNA in the preoperative (preop) and postoperative period (postop), and its prognostic significance in patients with breast cancer. METHODS: A cohort of patients with breast cancer undergoing curative surgery with available blood samples preoperatively and postoperatively (Post op) at either Post op time period; week 1-2, week 3-4 or weeks 5-12 were enrolled...
March 5, 2024: Surgical Oncology
#2
JOURNAL ARTICLE
Rosalie B T M Sterenborg, Inga Steinbrenner, Yong Li, Melissa N Bujnis, Tatsuhiko Naito, Eirini Marouli, Tessel E Galesloot, Oladapo Babajide, Laura Andreasen, Arne Astrup, Bjørn Olav Åsvold, Stefania Bandinelli, Marian Beekman, John P Beilby, Jette Bork-Jensen, Thibaud Boutin, Jennifer A Brody, Suzanne J Brown, Ben Brumpton, Purdey J Campbell, Anne R Cappola, Graziano Ceresini, Layal Chaker, Daniel I Chasman, Maria Pina Concas, Rodrigo Coutinho de Almeida, Simone M Cross, Francesco Cucca, Ian J Deary, Alisa Devedzic Kjaergaard, Justin B Echouffo Tcheugui, Christina Ellervik, Johan G Eriksson, Luigi Ferrucci, Jan Freudenberg, Christian Fuchsberger, Christian Gieger, Franco Giulianini, Martin Gögele, Sarah E Graham, Niels Grarup, Ivana Gunjača, Torben Hansen, Barbara N Harding, Sarah E Harris, Stig Haunsø, Caroline Hayward, Jennie Hui, Till Ittermann, J Wouter Jukema, Eero Kajantie, Jørgen K Kanters, Line L Kårhus, Lambertus A L M Kiemeney, Margreet Kloppenburg, Brigitte Kühnel, Jari Lahti, Claudia Langenberg, Bruno Lapauw, Graham Leese, Shuo Li, David C M Liewald, Allan Linneberg, Jesus V T Lominchar, Jian'an Luan, Nicholas G Martin, Antonela Matana, Marcel E Meima, Thomas Meitinger, Ingrid Meulenbelt, Braxton D Mitchell, Line T Møllehave, Samia Mora, Silvia Naitza, Matthias Nauck, Romana T Netea-Maier, Raymond Noordam, Casia Nursyifa, Yukinori Okada, Stefano Onano, Areti Papadopoulou, Colin N A Palmer, Cristian Pattaro, Oluf Pedersen, Annette Peters, Maik Pietzner, Ozren Polašek, Peter P Pramstaller, Bruce M Psaty, Ante Punda, Debashree Ray, Paul Redmond, J Brent Richards, Paul M Ridker, Tom C Russ, Kathleen A Ryan, Morten Salling Olesen, Ulla T Schultheiss, Elizabeth Selvin, Moneeza K Siddiqui, Carlo Sidore, P Eline Slagboom, Thorkild I A Sørensen, Enrique Soto-Pedre, Tim D Spector, Beatrice Spedicati, Sundararajan Srinivasan, John M Starr, David J Stott, Toshiko Tanaka, Vesela Torlak, Stella Trompet, Johanna Tuhkanen, André G Uitterlinden, Erik B van den Akker, Tibbert van den Eynde, Melanie M van der Klauw, Diana van Heemst, Charlotte Verroken, W Edward Visser, Dina Vojinovic, Henry Völzke, Melanie Waldenberger, John P Walsh, Nicholas J Wareham, Stefan Weiss, Cristen J Willer, Scott G Wilson, Bruce H R Wolffenbuttel, Hanneke J C M Wouters, Margaret J Wright, Qiong Yang, Tatijana Zemunik, Wei Zhou, Gu Zhu, Sebastian Zöllner, Johannes W A Smit, Robin P Peeters, Anna Köttgen, Alexander Teumer, Marco Medici
To date only a fraction of the genetic footprint of thyroid function has been clarified. We report a genome-wide association study meta-analysis of thyroid function in up to 271,040 individuals of European ancestry, including reference range thyrotropin (TSH), free thyroxine (FT4), free and total triiodothyronine (T3), proxies for metabolism (T3/FT4 ratio) as well as dichotomized high and low TSH levels. We revealed 259 independent significant associations for TSH (61% novel), 85 for FT4 (67% novel), and 62 novel signals for the T3 related traits...
January 30, 2024: Nature Communications
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JOURNAL ARTICLE
Adrienne Tin, Alison E Fohner, Qiong Yang, Jennifer A Brody, Gail Davies, Jie Yao, Dan Liu, Ilana Caro, Joni V Lindbohm, Michael R Duggan, Osorio Meirelles, Sarah E Harris, Valborg Gudmundsdottir, Adele M Taylor, Albert Henry, Alexa S Beiser, Ali Shojaie, Annabell Coors, Annette L Fitzpatrick, Claudia Langenberg, Claudia L Satizabal, Colleen M Sitlani, Eleanor Wheeler, Elliot M Tucker-Drob, Jan Bressler, Josef Coresh, Joshua C Bis, Julián Candia, Lori L Jennings, Maik Pietzner, Mark Lathrop, Oscar L Lopez, Paul Redmond, Robert E Gerszten, Stephen S Rich, Susan R Heckbert, Thomas R Austin, Timothy M Hughes, Toshiko Tanaka, Valur Emilsson, Ramachandran S Vasan, Xiuqing Guo, Yineng Zhu, Christophe Tzourio, Jerome I Rotter, Keenan A Walker, Luigi Ferrucci, Mika Kivimäki, Monique M B Breteler, Simon R Cox, Stephanie Debette, Thomas H Mosley, Vilmundur G Gudnason, Lenore J Launer, Bruce M Psaty, Sudha Seshadri, Myriam Fornage
Identifying circulating proteins associated with cognitive function may point to biomarkers and molecular process of cognitive impairment. Few studies have investigated the association between circulating proteins and cognitive function. We identify 246 protein measures quantified by the SomaScan assay as associated with cognitive function (p < 4.9E-5, n up to 7289). Of these, 45 were replicated using SomaScan data, and three were replicated using Olink data at Bonferroni-corrected significance...
November 3, 2023: Communications Biology
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REVIEW
Martyna Bakierzynska, Ms Carolyn Cullinane, Henry Paul Redmond, Mark Corrigan
Breast Cancer (BC) is the most common cancer amongst women. The chemo-preventative effects of aspirin on breast cancer have been demonstrated in several longitudinal studies however previous meta-analysis have shown inconsistent results. This study aimed to assess the relationship between aspirin use and BC risk, and to determine if there is a dose-response relationship between aspirin and BC risk. Studies incorporating BC risk with aspirin use published within the last twenty years were included. The study report is based on the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) and Meta-Analysis of Observational Studies in Epidemiology...
October 2023: European Journal of Surgical Oncology
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JOURNAL ARTICLE
Armin Ghomeshi, Parris Diaz, Valencia Henry, Ranjith Ramasamy, Thomas A Masterson
Introduction With the leaked Supreme Court draft regarding Roe vs. Wade, substantial public reactions followed as the horizon of abortion laws within the United States of America have been changing. We sought to compare internet searches for vasectomy and tubal ligation seven days following the leaked draft on May 2, 2022. Methods We used public data provided by Google Trends to investigate the interest and geographic distribution of searches for the two forms of permanent contraception: Vasectomy and tubal ligation...
October 2022: Curēus
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JOURNAL ARTICLE
Jim Byrne, Samuel Keogh, Carolyn Cullinane, Zeeshan Razzaq, Henry Paul Redmond
Objective: Assessment of the readability and quality of online health information regarding parathyroidectomy. Study Design: Cross-sectional analysis. Setting: Websites providing patient-oriented health information regarding parathyroidectomy obtained via the Google search engine. Methods: The top 75 Google search results for "parathyroidectomy,""parathyroid surgery," and "parathyroid gland removal" were reviewed. Websites were categorized by website type and country of origin...
October 2022: OTO Open
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JOURNAL ARTICLE
Fara Hassan, Jiang Huai Wang, Carolyn Cullinane, Michael Ita, Mark Corrigan, Donal Peter O'Leary, Henry Paul Redmond
BACKGROUND: Circulating cell-free DNA (cfDNA) is a potential non-invasive biomarker of disease status in patients with cancer, and provides important diagnostic and prognostic information in breast cancer. The goal of this study was to quantify cfDNA concentrations during the perioperative period and investigate its potential utility to detect recurrence outcomes in patients with breast cancer. METHODS: Sixty-two (n = 62) patients with non-metastatic breast cancer, undergoing curative-intent surgery were screened for inclusion...
April 3, 2022: Surgical Oncology
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JOURNAL ARTICLE
Michael I Ita, Jiang H Wang, Cynthia C Heffron, Derek G Power, Yvonne Nolan, André Toulouse, Chris C H Lim, Noel Fanning, Henry P Redmond
BACKGROUND/AIM: Current treatment strategies for advanced melanoma require serial assessment of disease status in affected patients. In this study, we sought to examine the relationship between radiographic tumour burden and blood borne biomarkers including plasma cfDNA, serum LDH, plasma VEGF, PD-L1 and IFN-γ in advanced melanoma patients receiving immunotherapy. We hypothesized that a combination of these explanatory variables in a suitable regression analysis model may predict changes in tumour burden during patient treatment...
February 2022: Anticancer Research
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JOURNAL ARTICLE
Michael Itak Ita, Jiang Huai Wang, André Toulouse, Chris Lim, Noel Fanning, Michael O'Sullivan, Yvonne Nolan, George Finbarr Kaar, Henry Paul Redmond
BACKGROUND: Research into the potential utility of plasma-derived circulating cell-free nucleic acids as non-invasive adjuncts to radiological imaging have been occasioned by the invasive nature of brain tumour biopsy. The objective of this study was to determine whether significant differences exist in the plasma transcriptomic profile of glioma patients relative to differences in their tumour characteristics, and also whether any observed differences were representative of synchronously obtained glioma samples and TCGA glioma-derived RNA...
March 2022: Acta Neurochirurgica
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JOURNAL ARTICLE
Christina A Fleming, Emer P O'Connell, Richard G Kavanagh, Donal P O'Leary, Maria Twomey, Mark A Corrigan, Jiang H Wang, Michael M Maher, Owen J O'Connor, Henry P Redmond
Importance: Obesity, particularly visceral obesity and sarcopenia, are poor prognostic indicators in colon cancer. Objectives: To explore the association between body composition profiles and 5-year colon cancer outcomes and delineate the associated underlying inflammatory processes. Design, Setting, and Participants: This multicenter translational cohort study included patients with nonmetastatic colon cancer who did not have underlying chronic inflammatory disorders and were not receiving anti-inflammatory drugs referred to tertiary cancer centers from 2009 to 2015...
August 2, 2021: JAMA Network Open
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JOURNAL ARTICLE
Michael Itak Ita, Jiang Huai Wang, Noel Fanning, George Kaar, Chris Lim, Henry Paul Redmond
BACKGROUND: Blood borne cell free nucleic acids are increasingly emerging as significant non-invasive adjuncts to current methods of disease status evaluation in cancer patients. In this study, we sought to examine whether significant differences exist in the plasma transcriptomic profile of advanced melanoma patients with a high disease burden compared to patients with a low disease burden or therapeutic response. METHODS: Pathway focussed gene expression analysis was performed using cDNA derived from the plasma circulating cell free messenger ribonucleic acid (ccfmRNA) samples of twenty-two patients with advanced melanoma...
September 2021: Acta Oncologica
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JOURNAL ARTICLE
Ravi Medikonda, Siddhartha Srivastava, Timothy Kim, Yuanxuan Xia, Jennifer Kim, Christopher Jackson, Jon Weingart, Debraj Mukherjee, Chetan Bettegowda, Gary Gallia, Henry Brem, Kristin Redmond, Vered Stearns, Lawrence Kleinberg, Michael Lim
BACKGROUND: Brain metastases are common in patients with breast cancer, and those with triple negative status have an even higher risk. Triple negative status is currently not considered when managing brain metastases. OBJECTIVE: To determine whether triple negative breast cancer (TNBC) patients with brain metastases have a higher burden of intracranial disease and whether WBRT has a survival benefit in this cohort of patients. METHODS: We conducted a retrospective cohort study with 85 patients meeting the inclusion criteria...
April 2021: Journal of Neuro-oncology
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JOURNAL ARTICLE
Carolyn Cullinane, Christina Fleming, Donal Peter O'Leary, Fara Hassan, Louise Kelly, Martin J O'Sullivan, Mark Antony Corrigan, Henry Paul Redmond
Importance: Fragmented DNA is continuously released into the circulation following apoptosis and necrosis of both cancerous and noncancerous cells; when it is released by cancer cells, it is specifically known as circulating tumor DNA (ctDNA). Previous studies have suggested that ctDNA can reflect tumor burden and guide potential therapeutic targets. Objective: To determine the association of ctDNA with breast cancer disease-free survival (DFS) and progression-free survival in early, locally advanced, and metastatic breast cancer...
November 2, 2020: JAMA Network Open
#14
JOURNAL ARTICLE
Carolyn M Cullinane, James Byrne, Liga Akmenkalne, Donal P O' Leary, Alissa M Connors, Mark A Corrigan, Henry Paul Redmond, Louise Kelly, Martin J O' Sullivan
Background. Breast screening has decreased morbidity and mortality due to detection of early, non-palpable breast cancers. One of the challenges of performing breast-conserving surgery on non-palpable breast tumours is accurate localization of the cancer. We aimed to perform a feasibility study to examine the outcomes associated with the introduction of a novel radiofrequency identification system (RFID) called LOCalizer as an alternative to traditional wire-guided localization. Methods. Data were prospectively collected on all patients undergoing breast-conserving surgery using the LOCalizer RFID system in a regional cancer centre between July 2019 and March 2020...
October 21, 2020: Surgical Innovation
#15
REVIEW
Carolyn Cullinane, Ben Creavin, Donal Peter O'Leary, Martin J O'Sullivan, Louise Kelly, Henry Paul Redmond, Mark Antony Corrigan
The systemic inflammatory response plays a role in tumor progression and development. The neutrophil to lymphocyte ratio (NLR) is a biochemical marker of systemic inflammation and is increasingly gaining appreciation for its prognostic role in predicting breast cancer outcomes. Previous research has demonstrated that patients who achieve a complete pathologic response (pCR) to neoadjuvant breast cancer treatment have a more favorable disease-free survival. This study aimed to assess whether the NLR can predict pCR to neoadjuvant therapy in breast cancer...
December 2020: Clinical Breast Cancer
#16
JOURNAL ARTICLE
David Cagney, Michael Hanrahan, Zeeshan Razzaq, Mudassar Majeed, Donal Peter O'Leary, Henry Paul Redmond
BACKGROUND: Laparoscopic transperitoneal and retroperitoneoscopic adrenalectomy have largely replaced open adrenal surgery, particularly in benign disease. Laparoscopic surgery results in less post-operative pain, fewer surgical site complications and reduced length of hospital stay. The aim of this retrospective study was to analyse the characteristics of patients and evolution of surgical technique in adrenal surgery at Cork University Hospital over a 12-year period. METHODS: All cases of adrenalectomy between January 1st, 2007 and December 31st, 2018 were retrospectively reviewed...
March 5, 2020: Irish Journal of Medical Science
#17
RANDOMIZED CONTROLLED TRIAL
Bruce C V Campbell, Peter J Mitchell, Leonid Churilov, Nawaf Yassi, Timothy J Kleinig, Richard J Dowling, Bernard Yan, Steven J Bush, Vincent Thijs, Rebecca Scroop, Marion Simpson, Mark Brooks, Hamed Asadi, Teddy Y Wu, Darshan G Shah, Tissa Wijeratne, Henry Zhao, Fana Alemseged, Felix Ng, Peter Bailey, Henry Rice, Laetitia de Villiers, Helen M Dewey, Philip M C Choi, Helen Brown, Kendal Redmond, David Leggett, John N Fink, Wayne Collecutt, Thomas Kraemer, Martin Krause, Dennis Cordato, Deborah Field, Henry Ma, Bill O'Brien, Benjamin Clissold, Ferdinand Miteff, Anna Clissold, Geoffrey C Cloud, Leslie E Bolitho, Luke Bonavia, Arup Bhattacharya, Alistair Wright, Abul Mamun, Fintan O'Rourke, John Worthington, Andrew A Wong, Christopher R Levi, Christopher F Bladin, Gagan Sharma, Patricia M Desmond, Mark W Parsons, Geoffrey A Donnan, Stephen M Davis
Importance: Intravenous thrombolysis with tenecteplase improves reperfusion prior to endovascular thrombectomy for ischemic stroke compared with alteplase. Objective: To determine whether 0.40 mg/kg of tenecteplase safely improves reperfusion before endovascular thrombectomy vs 0.25 mg/kg of tenecteplase in patients with large vessel occlusion ischemic stroke. Design, Setting, and Participants: Randomized clinical trial at 27 hospitals in Australia and 1 in New Zealand using open-label treatment and blinded assessment of radiological and clinical outcomes...
April 7, 2020: JAMA
#18
JOURNAL ARTICLE
David Cagney, Lydia Simmons, Donal Peter O'Leary, Mark Corrigan, Louise Kelly, M J O'Sullivan, Aaron Liew, Henry Paul Redmond
BACKGROUND: Negative pressure wound therapy (NPWT) is a promising advance in the management of closed surgical incisions. NPWT application induces several effects locally within the wound including reduced lateral tension and improving lymphatic drainage. As a result, NPWT may improve wound healing and reduce surgical site complications. We aim to evaluate the efficacy of prophylactic application of NPWT in preventing surgical site complications for closed incisions in breast surgery...
May 2020: World Journal of Surgery
#19
JOURNAL ARTICLE
Angela N Henderson-Redmond, Caitlin M Nealon, Brian J Davis, Matthew B Yuill, Diana E Sepulveda, Henry Blanton, Mary K Piscura, Michael L Zee, Chris P Haskins, David J Marcus, Ken Mackie, Josee Guindon, Daniel J Morgan
Tolerance to the antinociceptive effects of cannabinoids represents a significant limitation to their clinical use in managing chronic pain. Tolerance likely results from desensitization and down-regulation of the cannabinoid type 1 receptor (CB1 R), with CB1 R desensitization occurring via phosphorylation of CB1 Rs by a G protein-coupled receptor kinase and subsequent association with an arrestin protein. Previous studies have shown that (1) desensitization-resistant S426A/S430A mice exhibit a modest delay in tolerance for Δ9 -THC and CP55,940 but a more pronounced disruption in tolerance for WIN 55,212-2 and (2) that c-Jun N-terminal kinase (JNK) signaling may selectively mediate antinociceptive tolerance to morphine compared to other opioid analgesics...
November 20, 2019: Neuropharmacology
#20
JOURNAL ARTICLE
Mary P Chang, Yuanzheng Lu, Brian Leroux, Elisabete Aramendi Ecenarro, Pamela Owens, Henry E Wang, Ahamed H Idris
AIM OF STUDY: To determine the association between bioimpedence-detected ventilation and out-of-hospital cardiac arrest (OHCA) outcomes. METHODS: This is a retrospective, observational study of 560 OHCA patients from the Dallas-Fort Worth site enrolled in the Resuscitation Outcomes Consortium Trial of Continuous or Interrupted Chest Compressions During CPR from 4/2012 to 7/2015. We measured bioimpedance ventilation (lung inflation) waveforms in the pause between chest compression segments (Physio-Control LIFEPAK 12 and 15, Redmond, WA) recorded through defibrillation pads...
August 2019: Resuscitation
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