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Henry p Redmond

P Maheshwari, J Alphonse, A Henry, J Wang, S J Redmond, A Welsh
OBJECTIVES: To determine whether there is beat-to-beat (BTB) variability in the fetal left myocardial performance index (MPI) as evaluated by an automated system, and whether MPI and fetal heart rate (FHR) correlate. METHODS: Prospective cross-sectional study of women at 20-38 weeks gestation with uncomplicated, morphologically normal singleton pregnancies. Multiple cineloops for left MPI measurement were acquired during a single examination in each fetus. Raw cineloop data was analysed by our automated MPI system (ICC of 1...
July 8, 2016: Ultrasound in Obstetrics & Gynecology
Emer P O'Connell, Donal P O'Leary, Katrina Fogarty, Zeb J Khan, Henry P Redmond
To analyse the patient demographics, tumour characteristics and follow-up data of patients with recurrence of melanoma following a negative sentinel lymph node biopsy. A retrospective review of a prospectively maintained melanoma database was conducted. Melanoma patients who had a negative sentinel lymph node were identified and we performed statistical analysis on their respective demographics, tumour histology characteristics and follow-up data. Of 164 patients studied, 40 (24%) had a recurrence of melanoma at a median of 39...
February 2016: Melanoma Research
A W Welsh, P Maheshwari, J Wang, A Henry, D Chang, F Crispi, H M Gardiner, E Hernandez-Andrade, N Meriki, S Redmond, S Yagel
OBJECTIVE: To compare automated measurements of the fetal left myocardial performance index (MPI) with manual measurements for absolute value, repeatability and waveform acceptability. METHODS: This was a multicenter international online study using images from uncomplicated, morphologically normal singleton pregnancies (16-38 weeks' gestation). Single Doppler ultrasound cardiac cycle images of 25 cases were selected, triplicated and randomized (n = 75). Six senior observers, unaware of the repetition of images, manually calculated MPI for each waveform and the results were compared with automation...
October 2016: Ultrasound in Obstetrics & Gynecology
Mina C Johnson-Glenberg, Caroline Savio-Ramos, Hue Henry
Objective: A feasibility study was run on an embodied exergame designed to teach 4th-12th grade students about nutrition and several U.S. Department of Agriculture (USDA) MyPlate guidelines. The study assessed efficacy on a new version of a game that was first implemented on an immersive platform and published in this journal in 2013. The earlier "Alien Health" game was redesigned for use with the Microsoft(®) (Redmond, WA) Kinect(®) sensor. Players learned about the amount of nutrients and optimizers in common food items and practiced making food choices while engaging in short cardio exercises...
August 1, 2014: Games for Health
Andrew P Coveney, Timothy Switzer, Mark A Corrigan, Henry P Redmond
BACKGROUND: Psychologists have previously demonstrated that information recall is context dependent. However, how this influences the way we deliver medical education is unclear. This study aimed to determine if changing the recall context from the learning context affects the ability of medical students to recall information. METHODS: Using a free recall experimental model, fourteen medical student participants were administered audio lists of 30 words in two separate learning environments, a tutorial room and an operating theatre...
2013: BMC Medical Education
Chythanya Rajanna, Gary Ouellette, Mohammed Rashid, Adam Zemla, Mark Karavis, Carol Zhou, Tamara Revazishvili, Brady Redmond, Lauren McNew, Lela Bakanidze, Paata Imnadze, Bryan Rivers, Evan W Skowronski, Kevin P O'Connell, Alexander Sulakvelidze, Henry S Gibbons
We describe here a strain of Yersinia pestis, G1670A, which exhibits a baseline mutation rate elevated 250-fold over wild-type Y. pestis. The responsible mutation, a C to T substitution in the mutS gene, results in the transition of a highly conserved leucine at position 689 to arginine (mutS(L689R)). When the MutSL 689R protein of G1670A was expressed in a ΔmutS derivative of Y. pestis strain EV76, mutation rates observed were equivalent to those observed in G1670A, consistent with a causal association between the mutS mutation and the mutator phenotype...
June 2013: FEMS Microbiology Letters
Edel M Quinn, Mark A Corrigan, Seamus M McHugh, David Murphy, John O'Mullane, Arnold D Hill, Henry Paul Redmond
OBJECTIVE: Breast cancer is the cancer most commonly searched for on the internet. Our aim was to assess daily new breast cancer related posting on the internet. METHODS: We analyzed numbers of new daily posts for common cancers for one month and subsequently analyzed content of 1426 breast cancer related posts. We also assessed use of online discussion forums for breast cancer related dialogue. RESULTS: Breast related topics had significantly more posts per day compared to others (mean 66...
February 2013: Breast: Official Journal of the European Society of Mastology
Peter M Neary, Owen J O'Connor, Azher Shafiq, Edel M Quinn, Justin J Kelly, Buckley Juliette, Ronan A Cahill, Josephine Barry, Henry P Redmond
BACKGROUND: Thyroid drains following thyroid surgery are routinely used despite minimal supportive evidence. Our aim in this study is to determine the impact of routine open drainage of the thyroid bed postoperatively on ultrasound-determined fluid accumulation at 24 hours. METHODS: We conducted a prospective randomised clinical trial on patients undergoing thyroid surgery. Patients were randomly assigned to a drain group (n = 49) or a no-drain group (n = 44) immediately prior to wound closure...
2012: World Journal of Surgical Oncology
Edel M Quinn, JiangHuai Wang, Henry P Redmond
Endotoxin tolerance is a phenomenon where cells show reduced responsiveness toward repeated endotoxin stimulation. Regulation of tolerance occurs at multiple levels of the cell signaling cascade, and many of these levels are potentially regulated by miRNA, which are a class of small RNA that bind to mRNA to down-regulate gene expression at the post-transcriptional level. Roles have been identified for miR-146a, miR-221, miR-579, miR-125b, miR-155, let-7e, and miR-98 in regulating the TLR4 signaling pathway during the development of endotoxin tolerance at receptor, signaling pathway, and gene transcription and translational levels...
May 2012: Journal of Leukocyte Biology
Masayuki Iyanaga, Randal Gray, Shannon W Stephens, Olajide Akinsanya, Joel Rodgers, Kathleen Smyrski, Henry E Wang
OBJECTIVE: While cardiopulmonary resuscitation (CPR) chest compression fraction (CCF) is associated with out-of-hospital cardiac arrest (OHCA) outcomes, there is no standard method for the determination of CCF. We compared nine methods for calculating CCF. METHODS: We studied consecutive adult OHCA patients treated by Alabama Emergency Medical Services (EMS) agencies of the Resuscitation Outcomes Consortium (ROC) during January 1, 2010 to October 28, 2010. Paramedics used portable cardiac monitors with real-time chest compression detection technology (LifePak 12, Physio-Control, Redmond, WA)...
May 2012: Resuscitation
Edel Marie Quinn, David E Kearney, Justin Kelly, Catherine Keohane, Henry Paul Redmond
BACKGROUND: Temporal artery biopsy (TAB) is performed during the diagnostic workup for giant cell arteritis (GCA), a vasculitis with the potential to cause irreversible blindness or stroke. However, treatment is often started on clinical grounds, and TAB result frequently does not influence patient management. The aim of this study was to assess the need for TAB in cases of suspected GCA. METHODS: We performed a retrospective review of 185 TABs performed in our institution from 1990 to 2010...
July 2012: Annals of Vascular Surgery
S Tsao, M Yao, H Tsao, F P Henry, Y Zhao, J J Kochevar, R W Redmond, I E Kochevar
BACKGROUND: Apposition of wound edges by sutures provides a temporary scaffold and tension support for healing. We have developed a novel tissue-sealing technology, photoactivated tissue bonding (PTB), which immediately crosslinks proteins between tissue planes, thereby sealing on a molecular scale. OBJECTIVES: To determine the effectiveness of PTB for superficial closure of skin excisions and to compare the results with standard epidermal suturing. METHODS: A split-lesion, paired comparison study of 31 skin excisions was performed...
March 2012: British Journal of Dermatology
Osama Al Sahaf, Eddie Myers, Mohamed Jawad, Tara J Browne, Desmond C Winter, Henry P Redmond
BACKGROUND: The status of resected lymph nodes in colon cancer determines prognosis and further treatment. The American Joint Committee on Cancer staging system has designated extramural nodules as nonnodal disease and classified them as extensions of the T category in the sixth edition and as site-specific tumor deposits in the seventh edition. Extracapsular lymph node extension is an established poor prognostic indicator in many cancers. Its significance in colon cancer has not been extensively investigated...
August 2011: Diseases of the Colon and Rectum
Kishore K Doddakula, Peter M Neary, Jiang H Wang, Shastri Sookhai, Aongus O'Donnell, Tom Aherne, David J Bouchier-Hayes, Henry P Redmond
BACKGROUND: Cardiopulmonary bypass results in ischemia/reperfusion (I/R)-induced endotoxemia. We conducted a prospective randomized trial to investigate the effect of taurolidine, an antiendotoxin agent with antioxidant and membrane-stabilizing properties, on patients undergoing coronary artery bypass grafting (CABG). METHODS: A total of 60 patients undergoing CABG were randomized into 4 groups. St Thomas' Hospital cold crystalloid cardioplegia was used in groups A and B, and cold blood cardioplegia in groups C and D...
September 2010: Surgery
William S David, Namita Goyal, Francis P Henry, Laura E Baldassari, Robert W Redmond
Motor unit number estimation (MUNE) allows for quantitative assessment of functional motor units in a nerve. Several techniques have been applied to human studies. Although MUNE has been performed in animals to study neurological disorders, reproducibility has not been addressed. We analyzed the test-retest reproducibility of an incremental MUNE technique in rabbits and performed histological correlation. A peroneal MUNE was performed in 9 rabbits on two occasions separated by 30 days. MUNE was then performed on 18 rabbits prior to euthanize...
June 2010: Muscle & Nerve
Min Yao, Anna Yaroslavsky, Frank P Henry, Robert W Redmond, Irene E Kochevar
BACKGROUND AND OBJECTIVE: We have developed a light-activated method called photochemical tissue bonding (PTB) for closing wounds using green light and a photosensitizing dye (Rose Bengal-RB) to initiate photochemical crosslinking of wound surface proteins. These studies were designed to determine whether RB causes phototoxicity during closure of skin incisions with PTB. STUDY DESIGN/MATERIALS AND METHODS: RB phototoxicity was evaluated after sealing incisions in porcine skin ex vivo and rabbit skin in vivo using PTB (1 mM RB, 100 J/cm(2), 532 nm, 0...
February 2010: Lasers in Surgery and Medicine
Peter M Neary, Patrick Hallihan, Jiang H Wang, Rolf W Pfirrmann, David J Bouchier-Hayes, Henry P Redmond
BACKGROUND AND DESIGN: Taurolidine consists of two taurinamide rings derived from the naturally occurring amino acid taurine. It has been utilized to prevent adhesions, as an antimicrobial, and as an anti-inflammatory agent. More recently, it has been found to exert antineoplastic activity. We reviewed the literature regarding taurolidine and its role in cancer treatment. RESULTS AND CONCLUSION: Taurolidine induces cancer cell death through a variety of mechanisms...
April 2010: Annals of Surgical Oncology
Adrian W O'Sullivan, Jiang H Wang, Henry P Redmond
BACKGROUND: The surgical insult induces an inflammatory response that activates P38 MAP kinases and solid tumours can also release cytokines. Therfore inhibition of these pathways may reduce tumour growth We set out to examine the effects of P38-MAPK inhibition on apoptosis, proliferation, VEGF release and cell cycle effects in-vitro and on primary tumour growth in-vivo. METHODS: 4T-1 cells (2 x 105 cells/well) were incubated, in 24 well plates with control, 25, 50 or 100 ng/ml of SB-202190 for 24 hours...
2009: World Journal of Surgical Oncology
Adrian O'Sullivan, Diarmuid O'Malley, John Coffey, Jiang Huai Wang, Henry Redmond
BACKGROUND: Inflammatory stimuli that activate p38 mitogen-activated protein kinase (MAPK) and nuclear factor-kappaB (NF-kappaB) contribute to inflammation and fibroblast function, which are necessary components of incision and wound healing. Inhibition of these signal transduction pathways may provide novel strategies to prevent sepsis but may interfere with healing. We examined the effects of inhibiting p38 activation and NF-kappaB translation on incision healing in a dorsal slit model...
February 2010: Surgical Infections
Francis P Henry, Namita A Goyal, William S David, David Wes, Kenneth E Bujold, Mark A Randolph, Jonathan M Winograd, Irene E Kochevar, Robert W Redmond
BACKGROUND: The surgical approach used today in the repair of peripheral nerve injuries rarely achieves full functional recovery. This study determines whether isolation of the nerve repair site using photochemical tissue bonding (PTB) in combination with human amniotic membrane can improve both functional and histologic recovery. METHODS: New Zealand white rabbits (n = 24) underwent transection of the right common peroneal nerve. Epineural nerve repair was performed using 10-0 nylon sutures...
March 2009: Surgery
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