Adrian T Billeter, Jason Hellmann, Henry Roberts, Devin Druen, Sarah A Gardner, Harshini Sarojini, Susan Galandiuk, Sufan Chien, Aruni Bhatnagar, Matthew Spite, Hiram C Polk
Therapeutic hypothermia is commonly used to improve neurological outcomes in patients after cardiac arrest. However, therapeutic hypothermia increases sepsis risk and unintentional hypothermia in surgical patients increases infectious complications. Nonetheless, the molecular mechanisms by which hypothermia dysregulates innate immunity are incompletely understood. We found that exposure of human monocytes to cold (32°C) potentiated LPS-induced production of TNF and IL-6, while blunting IL-10 production. This dysregulation was associated with increased expression of microRNA-155 (miR-155), which potentiates Toll-like receptor (TLR) signaling by negatively regulating Ship1 and Socs1...
December 2014: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology