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O Ak├ža, A Kurz, E Fleischmann, D Buggy, F Herbst, L Stocchi, S Galandiuk, S Iscoe, J Fisher, C C Apfel, D I Sessler
BACKGROUND: Tissue oxygenation is a strong predictor of surgical site infection (SSI). Mild intraoperative hypercapnia increases peripheral, gastrointestinal, and splanchnic tissue oxygenation and perfusion. Hypercapnia also has anti-inflammatory effects. However, it is unknown whether hypercapnia reduces SSI risk. We tested the hypothesis that mild intraoperative hypercapnia reduces the risk of SSI in patients having colon resection surgery. METHODS: With institutional review board approval and subject consent, patients having elective colon resection (e...
November 2013: British Journal of Anaesthesia
S Galandiuk
No abstract text is available yet for this article.
June 2013: British Journal of Surgery
S Galandiuk
No abstract text is available yet for this article.
July 2013: British Journal of Surgery
Ziad Kanaan, Shesh N Rai, M Robert Eichenberger, Christopher Barnes, Amy M Dworkin, Clayton Weller, Eric Cohen, Henry Roberts, Bobby Keskey, Robert E Petras, Nigel P S Crawford, Susan Galandiuk
One of the most serious complications faced by patients with inflammatory bowel disease (IBD) is the potential development of colorectal cancer (CRC). There is a compelling need to enhance the accuracy of cancer screening of IBD patients. MicroRNAs (miRNAs) are small nonprotein-coding RNAs that play important roles in CRC oncogenesis. In this study, we report differential miRNA expression in IBD patients with associated CRC from non-neoplastic tissue to dysplasia and eventually cancer. In addition, we identify and examine the role of dysregulated miRNAs in the TP53 pathway...
March 2012: Human Mutation
Ziad Kanaan, M Robert Eichenberger, Michael Young, Daniel Colliver, Nigel Crawford, Gary A Cobbs, David W Hein, Susan Galandiuk
BACKGROUND: Inflammatory bowel diseases (IBD) encompass inflammatory disorders affecting the gastrointestinal tract, primarily ulcerative colitis (UC) and Crohn's disease (CD). The risk of developing colorectal cancer (CRC) is increased in patients with IBD. The CCND1 protein is the regulatory subunit of an enzyme that inactivates the retinoblastoma protein, a tumor suppressor protein, and promotes progression through the G1-S phase of the cell cycle. The CCND1 870G-A gene polymorphism influences susceptibility to colorectal cancer...
January 2010: International Journal of Biological Markers
Aaron M Mulhall, Suhal S Mahid, Robert E Petras, Susan Galandiuk
PURPOSE: Diverticular-associated colitis significantly overlaps clinically with primary inflammatory bowel disease. However, the clinical and the pathologic features of diverticular-associated colitis suggest that it is a distinct clinical entity. METHODS: We performed a systematic review by use of multiple health care databases and gray literature, following predefined inclusion and exclusion criteria to determine the clinical, endoscopic, and pathologic features of diverticular-associated colitis, and recurrence rates following medical and surgical treatment...
June 2009: Diseases of the Colon and Rectum
Suhal S Mahid, Nadim S Jafri, Baylor C Brangers, Kyle S Minor, Carlton A Hornung, Susan Galandiuk
OBJECTIVE: To study the clinical results of surgical management in patients with right upper quadrant pain, a positive hepatobiliary iminodiacetic acid (HIDA) scan result, and no gallstones. DATA SOURCES: Health care databases and gray literature. STUDY SELECTION: Each article was scrutinized to determine whether it met inclusion criteria. Only abstracts, full articles, and gray literature that passed the detailed screening procedure were included...
February 2009: Archives of Surgery
Nadim S Jafri, Suhal S Mahid, Spencer R Idstein, Carlton A Hornung, Susan Galandiuk
BACKGROUND: The use of prophylactic systemic antibiotics to prevent infection and reduce mortality in severe acute pancreatitis (SAP) remains a contentious issue. We assessed the clinical outcome of patients with SAP treated with prophylactic antibiotics compared with that of patients not treated with antibiotics. METHODS: We performed a systematic search of MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials, using PubMed, Google Scholar, and Ovid as search engines without language restriction until the end of May 2008...
June 2009: American Journal of Surgery
S S Mahid, K S Minor, B C Brangers, G A Cobbs, S Galandiuk
Inflammatory bowel diseases (IBDs) affecting the colon [Crohn's disease (CD) and ulcerative colitis (UC)] are associated with an increased risk of colorectal cancer (CRC). Our previous work using oligonucleotide array data indicated that SMAD2 was significantly underexpressed in UC dysplastic tissue compared to benign UC. The aim of this current study was to determine whether single nucleotide polymorphisms (SNPs) within the SMAD2 gene are associated with IBD dysplasia/cancer. We performed an SNP haplotype-based case-control association study...
July 2008: International Journal of Biological Markers
S S Mahid, M Qadan, C A Hornung, S Galandiuk
BACKGROUND: Publication bias occurs when statistically non-significant (negative) findings are not published. It can profoundly affect the results of systematic reviews and meta-analyses. METHODS: Qualitative and quantitative methods of detecting publication bias are described, including their advantages and disadvantages. RESULTS AND CONCLUSION: Accepted quality standards for the reporting of meta-analyses recommend assessment of publication bias, but currently there is no uniform standard for reporting...
August 2008: British Journal of Surgery
Suhal S Mahid, Aaron M Mulhall, Ryan D Gholson, M Robert Eichenberger, Susan Galandiuk
BACKGROUND: Inflammatory bowel disease (IBD) is comprised of Crohn's disease (CD) and ulcerative colitis (UC). There are conflicting reports on whether African Americans have a more severe disease course, presentation, and more frequent extraintestinal manifestations (EIM). We examined the precise nature of this relationship by conducting a systematic review. METHODS: Using predefined inclusion criteria we searched multiple healthcare databases and Grey literature...
July 2008: Inflammatory Bowel Diseases
Matthias Turina, Aaron M Mulhall, Suhal S Mahid, Catheryn Yashar, Susan Galandiuk
HYPOTHESIS: Refractory complications from pelvic radiotherapy often require surgical treatment. Their management may be dictated by the primary tumor, radiation dose, and type and combination of radiation injuries, and may require transient diversion in most cases to guarantee good outcomes. DESIGN: Retrospective 10-year cohort analysis compared with statewide epidemiologic data. PATIENTS: During a 10-year period, 14 791 patients in Kentucky were treated with pelvic radiotherapy...
January 2008: Archives of Surgery
Suhal S Mahid, Daniel W Colliver, Nigel P S Crawford, Benjamin D Martini, Mark A Doll, David W Hein, Gary A Cobbs, Robert E Petras, Susan Galandiuk
BACKGROUND: N-acetyltransferase 1 (NAT1) and 2 (NAT2) are polymorphic isoenzymes responsible for the metabolism of numerous drugs and carcinogens. Acetylation catalyzed by NAT1 and NAT2 are important in metabolic activation of arylamines to electrophilic intermediates that initiate carcinogenesis. Inflammatory bowel diseases (IBD) consist of Crohn's disease (CD) and ulcerative colitis (UC), both are associated with increased colorectal cancer (CRC) risk. We hypothesized that NAT1 and/or NAT2 polymorphisms contribute to the increased cancer evident in IBD...
May 30, 2007: BMC Medical Genetics
Nigel P S Crawford, Daniel W Colliver, M Robert Eichenberger, Alisa A Funke, Valentina Kolodko, Gary A Cobbs, Robert E Petras, Susan Galandiuk
Inflammatory bowel disease (IBD; MIM# 266600) is subdivided on the basis of clinical findings as either Crohn's disease (CD), ulcerative colitis (UC), or indeterminate colitis (IC). Three previously described mutations within the IBD susceptibility gene CARD15 (R702W, G908R, 1007fs) increase susceptibility to CD with a terminal ileal and/or ileocolonic location and fibrostenosing behavior. We undertook an association study using 477 unrelated IBD patients (248 CD, 172 UC, 57 IC) and 104 population controls to determine whether these previously described associations could be replicated in a small, accurately phenotyped cohort...
October 2007: Digestive Diseases and Sciences
Suhal S Mahid, Kyle S Minor, Patrick L Stevens, Susan Galandiuk
The development of Crohn's disease (CD) is related to an interaction of genetic and environmental factors, with tobacco smoking being one of the most commonly studied environmental factors. In 1998, the Vienna classification was created to define CD by using three accepted clinical variables: age at diagnosis, disease behavior, and disease location. In this qualitative systematic review, articles examining the relationship between smoking and CD, using variables outlined in the Vienna classification, were identified utilizing multiple health databases...
November 2007: Digestive Diseases and Sciences
N S Jafri, S S Mahid, K S Minor, S R Idstein, C A Hornung, S Galandiuk
BACKGROUND: Despite numerous guidelines recommending prophylactic antibiotics prior to percutaneous endoscopic gastrostomy, their use remains controversial. AIM: To conduct a systematic literature review and performed meta-analyses to determine the benefit of antibiotic prophylaxis for percutaneous endoscopic gastrostomy placement. METHODS: We performed a systematic literature review by searching healthcare databases and grey literature for randomized-controlled trials of antibiotic prophylaxis against wound infection after percutaneous endoscopic gastrostomy...
March 15, 2007: Alimentary Pharmacology & Therapeutics
Suhal S Mahid, Kyle S Minor, Arnold J Stromberg, Susan Galandiuk
BACKGROUND: The highest prevalence of smoking in the United States is in Kentucky, where smoking typically begins in childhood. The state has many patients who suffer from inflammatory bowel diseases (IBD). The primary aim of this study was to assess whether exposure to active and/or passive tobacco smoke in childhood is related to the likelihood of developing IBD. METHODS: Recruited into this prospective study were a total of 672 participants (253 patients with Crohn's disease [CD], 177 patients with ulcerative colitis [UC], and 242 controls), all of whom were asked to complete the Behavioral Risk Factor Surveillance Survey modified by the addition of 4 questions on childhood passive smoke exposure...
April 2007: Inflammatory Bowel Diseases
Suhal S Mahid, Kyle S Minor, Roberto E Soto, Carlton A Hornung, Susan Galandiuk
OBJECTIVE: To assess whether there is a true effect of smoking on the 2 most prevalent forms of inflammatory bowel disease (IBD): Crohn disease (CD) and ulcerative colitis (UC). METHODS: For this meta-analysis, we searched multiple health care databases, including MEDLINE and EMBASE (January 1980 to January 2006), to examine the relationship between smoking and IBD. Keywords searched included smoking, Inflammatory bowel disease, Crohn's disease, and ulcerative colitis...
November 2006: Mayo Clinic Proceedings
S S Mahid, C A Hornung, K S Minor, M Turina, S Galandiuk
BACKGROUND: Understanding of data-reporting methods is imperative for correct interpretation of the medical literature as well as for proper performance of future clinical research. Recent developments in biostatistics have greatly changed the types of statistical analyses used and the minimum quality standards that must be maintained. METHOD: Different types of review are described, including systematic review with and without meta-analysis. Minimum reporting standards, sources of bias, both quantitative and qualitative, and references are discussed...
November 2006: British Journal of Surgery
Susan Galandiuk, Suhal S Mahid, Hiram C Polk, Matthias Turina, Mohan Rao, John N Lewis
BACKGROUND: The importance of rural operations is magnified by super-specialization, uneven geographic distribution, and special educational needs. Definition of practice patterns and quality measures are needed. METHODS: A statewide network of 60 operative specialists studied costs, quality, and outcomes in 17,319 patients undergoing 46 different specialty operations between 1998 and 2003, comparing 9,544 rural to 7,775 urban patients. These data are augmented by additional data from 5,339 operative patients in 2004...
October 2006: Surgery
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