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https://www.readbyqxmd.com/read/28915516/mog-antibodies-in-pediatric-neurology
#1
Peter Huppke
No abstract text is available yet for this article.
September 15, 2017: Neuropediatrics
https://www.readbyqxmd.com/read/28902363/ginkgetin-induces-g2-phase-arrest-in-hct116-colon-cancer-cells-through-the-modulation-of-b%C3%A2-myb-and-mirna34a-expression
#2
Yu-Jin Lee, Yeong-Rim Kang, So Young Lee, Yena Jin, Dong Cho Han, Byoung-Mog Kwon
Ginkgetin has been reported to display antitumor activity. However, the relevant pathway integrating cell cycle regulation and signaling pathways involved in growth inhibition in CRC cells remains to be identified. In this study, ginkgetin-treated HCT116 CRC cells exhibited significant dose-dependent growth inhibition with a GI50 value of 4.0 µM for 48-h treatment, together with apoptosis, via G2-phase cell cycle arrest. When HCT116 cells were treated with 10 µM ginkgetin for 48 h, the percentage of cells in G2/M phase increased by 2...
September 5, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28898256/carbidopa-a-drug-in-use-for-management-of-parkinson-disease-inhibits-t-cell-activation-and-autoimmunity
#3
Huabin Zhu, Henrique Lemos, Brinda Bhatt, Bianca N Islam, Abhijit Singh, Ashish Gurav, Lei Huang, Darren D Browning, Andrew Mellor, Sadanand Fulzele, Nagendra Singh
Carbidopa is a drug that blocks conversion of levodopa to dopamine outside of central nervous system (CNS) and thus inhibits unwanted side effects of levodopa on organs located outside of CNS during management of Parkinson's Disease (PD). PD is associated with increased expression of inflammatory genes in peripheral and central nervous system (CNS), infiltration of immune cells into brain, and increased numbers of activated/memory T cells. Animal models of PD have shown a critical role of T cells in inducing pathology in CNS...
2017: PloS One
https://www.readbyqxmd.com/read/28887429/nfm-cross-reactivity-to-mog-does-not-expand-a-critical-threshold-level-of-high-affinity-t-cells-necessary-for-onset-of-demyelinating-disease
#4
Lori Blanchfield, Joseph J Sabatino, Laurel Lawrence, Brian D Evavold
Of interest to the etiology of demyelinating autoimmune disease is the potential to aberrantly activate CD4(+) T cells due to cross-recognition of multiple self-epitopes such as has been suggested for myelin oligodendrocyte glycoprotein epitope 35-55 (MOG35-55) and neurofilament medium protein epitope 15-35 (NFM15-35). NFM15-35 is immunogenic in C57BL/6 mice but fails to induce demyelinating disease by polyclonal T cells despite having the same TCR contact residues as MOG35-55, a known encephalitogenic Ag...
September 8, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28878627/optic-nerve-degeneration-after-retinal-ischemia-reperfusion-in-a-rodent-model
#5
Marina Renner, Gesa Stute, Mohammad Alzureiqi, Jacqueline Reinhard, Susanne Wiemann, Heiko Schmid, Andreas Faissner, H Burkhard Dick, Stephanie C Joachim
Retinal ischemia is a common pathomechanism in many ocular disorders such as age-related macular degeneration (AMD), diabetic retinopathy, glaucoma or retinal vascular occlusion. Several studies demonstrated that ischemia/reperfusion (I/R) leads to morphological and functional changes of different retinal cell types. However, little is known about the ischemic effects on the optic nerve. The goal of this study was to evaluate these effects. Ischemia was induced by raising the intraocular pressure (IOP) in one eye of rats to 140 mmHg for 1 h followed by natural reperfusion...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28875859/myelin-oligodendrocyte-glycoprotein-and-multiple-sclerosis
#6
Maria-Eleni Androutsou, Anthi Tapeinou, Alexios Vlamis-Gardikas, Theodore Tselios
BACKGROUND: Myelin oligodendrocyte glycoprotein (MOG) is located on the external surface of myelin, a membranous component of the central nervous system (CNS) that forms the insulating lipid layer around neurons. The major MOG splicing variant (a1 transcript) encodes a transmembrane protein with an extracellular domain of an Ig variable (IgV) fold. MOG IgV domains from the same or different cells dimerize and contribute to the organization and maintenance of the myelin sheath in neurons...
September 6, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28874849/inhibitory-effect-of-obovatol-from-magnolia-obovata-on-the-salmonella-type-iii-secretion-system
#7
Won-Sik Choi, Tae Hun Lee, Se Jin Son, Tae Gyu Kim, Byoung-Mog Kwon, Hyeong-U Son, Sung Uk Kim, Sang-Han Lee
In many pathogenic Gram-negative bacteria, such as Salmonella, Escherichia coli, Yersinia and Chlamydia spp., which cause diseases in humans, the type III secretion system (TTSS) is an important virulence factor that translocates effector proteins into the cytosol of host cells. Thus, the TTSS is a good target for antibacterial agents. Here we used a hemolysis assay to search for TTSS inhibitors and found that a compound from Magnolia obovata called obovatol blocks the TTSS of Salmonella. Obovatol showed potent inhibitory activity (IC50=19...
September 6, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28872930/inconsistence-between-number-and-function-of-autoreactive-t-cells-in-the-course-of-experimental-autoimmune-encephalomyelitis
#8
Xin Wan, Weiya Pei, Yiming Zhang, Lei Zhang, Khawar Ali Shahzad, Tao Xu, Chuanlai Shen
BACKGROUND: Mouse experimental autoimmune encephalomyelitis (EAE) is widely used model of multiple sclerosis (MS). The role of autoreactive CD4(+) and CD8(+) T cells in the development of mouse EAE has been demonstrated. However, little information is available about the relation between the frequency and reactivity of myelin antigen-reactive CD4(+) and CD8(+) T cells in secondary lymphoid organs and their relevance with the inflammation and pathological lesion of CNS during the course of EAE mouse model...
September 5, 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28872459/mir-146a-modulates-autoreactive-th17-cell-differentiation-and-regulates-organ-specific-autoimmunity
#9
Bo Li, Xi Wang, In Young Choi, Yu-Chen Wang, Siyuan Liu, Alexander T Pham, Heesung Moon, Drake J Smith, Dinesh S Rao, Mark P Boldin, Lili Yang
Autoreactive CD4 T cells that differentiate into pathogenic Th17 cells can trigger autoimmune diseases. Therefore, investigating the regulatory network that modulates Th17 differentiation may yield important therapeutic insights. miR-146a has emerged as a critical modulator of immune reactions, but its role in regulating autoreactive Th17 cells and organ-specific autoimmunity remains largely unknown. Here, we have reported that miR-146a-deficient mice developed more severe experimental autoimmune encephalomyelitis (EAE), an animal model of human multiple sclerosis (MS)...
September 5, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28867896/neonatal-lipopolysaccharide-infection-causes-demyelination-and-behavioral-deficits-in-adult-and-senile-rat-brain
#10
Kavita Singh, Nisha Patro, M Pradeepa, Ishan Patro
BACKGROUND: Neonatal bacterial infections have been reported to cause white matter loss, although studies concerning the influence of infection on the expression of myelin and aging are still in their emerging state. PURPOSE: The present study aimed to investigate the effects of perinatal lipopolysaccharide (LPS) exposure on the myelination at different age points using histochemical and immunocytochemical techniques and the relative motor coordination. METHODS: A rat bacterial infection model was established by exposing the neonatal rats with LPS (0...
July 2017: Annals of Neurosciences
https://www.readbyqxmd.com/read/28865458/salutary-effects-of-glibenclamide-during-the-chronic-phase-of-murine-experimental-autoimmune-encephalomyelitis
#11
Volodymyr Gerzanich, Tapas K Makar, Poornachander Reddy Guda, Min Seong Kwon, Jesse A Stokum, Seung Kyoon Woo, Svetlana Ivanova, Alexander Ivanov, Rupal I Mehta, Alexandra Brooke Morris, Joseph Bryan, Christopher T Bever, J Marc Simard
BACKGROUND: In multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), inflammation is perpetuated by both infiltrating leukocytes and astrocytes. Recent work implicated SUR1-TRPM4 channels, expressed mostly by astrocytes, in murine EAE. We tested the hypothesis that pharmacological inhibition of SUR1 during the chronic phase of EAE would be beneficial. METHODS: EAE was induced in mice using myelin oligodendrocyte glycoprotein (MOG) 35-55. Glibenclamide (10 μg/day) was administered beginning 12 or 24 days later...
September 2, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28859212/mog-spectrum-disorders-and-role-of-mog-antibodies-in-clinical-practice
#12
Eva-Maria Hennes, Matthias Baumann, Christian Lechner, Kevin Rostásy
No abstract text is available yet for this article.
August 31, 2017: Neuropediatrics
https://www.readbyqxmd.com/read/28854914/factors-related-with-colorectal-and-stomach-cancer-screening-practice-among-disease-free-lung-cancer-survivors-in-korea
#13
Sang Min Park, Jongmog Lee, Young Ae Kim, Yoon Jung Chang, Moon Soo Kim, Young Mog Shim, Jae Ill Zo, Young Ho Yun
BACKGROUND: Lung cancer survivors are more likely to develop colorectal and stomach cancer than the general population. However, little is known about the current status of gastrointestinal cancer screening practices and related factors among lung cancer survivors. METHODS: We enrolled 829 disease-free lung cancer survivors ≥40 years of age, who had been treated at two hospitals from 2001 to 2006. The patients completed a questionnaire that included stomach and colorectal cancer screening after lung cancer treatment, as well as other sociodemographic variables...
August 30, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28851628/pde8-controls-cd4-t-cell-motility-through-the-pde8a-raf-1-kinase-signaling-complex
#14
Chaitali P Basole, Rebecca K Nguyen, Katie Lamothe, Amanda Vang, Robert Clark, George S Baillie, Paul M Epstein, Stefan Brocke
The levels of cAMP are regulated by phosphodiesterase enzymes (PDEs), which are targets for the treatment of inflammatory disorders. We have previously shown that PDE8 regulates T cell motility. Here, for the first time, we report that PDE8A exerts part of its control of T cell function through the V-raf-1 murine leukemia viral oncogene homolog 1 (Raf-1) kinase signaling pathway. To examine T cell motility under physiologic conditions, we analyzed T cell interactions with endothelial cells and ligands in flow assays...
August 26, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28844540/gynecologic-melanomas-a-clinicopathologic-and-molecular-analysis
#15
Aaron M Udager, Nora K Frisch, Linda J Hong, Marina Stasenko, Carolyn M Johnston, J Rebecca Liu, May P Chan, Paul W Harms, Douglas R Fullen, Amy Orsini, Dafydd G Thomas, Lori Lowe, Rajiv M Patel
OBJECTIVE: Melanoma originating from gynecologic sites (MOGS), including the vulva, vagina, and cervix, is a rare and aggressive form of melanoma with poor long-term clinical outcome. The clinicopathologic features of vulvar and non-vulvar tumors remain relatively understudied, and in contrast to cutaneous melanomas at non-sun-exposed sites, MOGS typically do not harbor BRAF mutations. Thus, we sought to analyze the clinicopathologic and molecular features of MOGS. METHODS: A large retrospective cohort of patients with MOGS (n=59) at a single large academic institution over a 28-year period was identified...
August 24, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28840314/what-proportion-of-aqp4-igg-negative-nmo-spectrum-disorder-patients-are-mog-igg-positive-a-cross-sectional-study-of-132-patients
#16
Shahd H M Hamid, Daniel Whittam, Kerry Mutch, Samantha Linaker, Tom Solomon, Kumar Das, Maneesh Bhojak, Anu Jacob
Antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) have been described in patients with neuromyelitis optica spectrum disorders (NMOSD) without aquaporin-4 antibodies (AQP4-IgG). We aimed to identify the proportion of AQP4-IgG-negative NMOSD patients who are seropositive for MOG-IgG. In a cross sectional study, we reviewed all patients seen in the National NMO clinic over the last 4 years (after the availability of MOG-IgG testing), including clinical information, MRI, and antibody tests. 261 unique patients were identified...
August 24, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28838402/ipsilateral-pleural-recurrence-after-diagnostic-transthoracic-needle-biopsy-in-pathological-stage-i-lung-cancer-patients-who-underwent-curative-resection
#17
Seong Mi Moon, Dae Geun Lee, Na Young Hwang, Soohyun Ahn, Hyun Lee, Byeong-Ho Jeong, Yong Soo Choi, Young Mog Shim, Tae Jeong Kim, Kyung Soo Lee, Hojoong Kim, O Jung Kwon, Kyung Jong Lee
OBJECTIVES: The relationship between transthoracic needle biopsy (TTNB) and pleural recurrence of cancer after curative lung resection remains unclear. We aimed to assess whether TTNB increases the ipsilateral pleural recurrence (IPR) rate and identify other potential risk factors for pleural recurrence after surgery. MATERIALS AND METHODS: This retrospective study included 392 patients with p-stage I non-small cell lung cancer with solid or part-solid nodules after curative lung resection in 2009-2010...
September 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28836399/multiple-sclerosis-gene-therapy-with-recombinant-viral-vectors-overexpression-of-il-4-leukemia-inhibitory-factor-and-il-10-in-wharton-s-jelly-stem-cells-used-in-eae-mice-model
#18
Ahmad Hosseini, Hajar Estiri, Haleh Akhavan Niaki, Akram Alizadeh, Baharak Abdolhossein Zadeh, Sayyed Mohammad Hossein Ghaderian, Akbar Farjadfar, Ali Fallah
OBJECTIVES: Immunotherapy and gene therapy play important roles in modern medicine. The aim of this study is to evaluate the overexpression of interleukin-4 (IL-4), IL-10 and leukemia inhibitory factor (LIF) in Wharton's jelly stem cells (WJSCs) in the experimental autoimmune encephalomyelitis (EAE) mice model. MATERIALS AND METHODS: In this experimental study, a DNA construction containing IL- 4, IL-10 and LIF was assembled to make a polycistronic vector (as the transfer vector)...
October 2017: Cell Journal
https://www.readbyqxmd.com/read/28828577/scavenger-receptor-a-mediates-the-clearance-and-immunological-screening-of-mda-modified-antigen-by-m2-type-macrophages
#19
Andreas Warnecke, Sonja Abele, Sravani Musunuri, Jonas Bergquist, Robert A Harris
In this study, we investigated the uptake of malondialdehyde (MDA)-modified myelin oligodendrocyte glycoprotein (MOG) in the context of lipid peroxidation and its implications in CNS autoimmunity. The use of custom-produced fluorescently labeled versions of MOG or MDA-modified MOG enabled us to study and quantify the uptake by different macrophage populations and to identify the responsible receptor, namely SRA. The SRA-mediated uptake of MDA-modified MOG is roughly tenfold more efficient compared to that of the native form...
August 21, 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/28820014/postinfectious-anti-myelin-oligodendrocyte-glycoprotein-antibody-positive-optic-neuritis-and-myelitis
#20
J P Vieira, J Sequeira, M J Brito
We report the case of a 9-year-old girl admitted with fever, headache, and a cerebrospinal fluid lymphocytic pleocytosis. Polymerase chain reaction was positive for human herpes virus 6. She subsequently developed ataxia and bilateral loss of vision. Magnetic resonance imaging (MRI) showed bilateral optic nerve lesions with extension to optic chiasm and a short-segment myelitis. Serologic studies were positive for Borrelia burgdorferi IgM. Anti-aquaporin 4 antibody was negative and anti-myelin oligodendrocyte glycoprotein antibody (MOG) positive...
January 1, 2017: Journal of Child Neurology
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