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https://www.readbyqxmd.com/read/28108257/working-memory-load-dependent-spatio-temporal-activity-of-single-trial-p3-response-detected-with-an-adaptive-wavelet-denoiser
#1
Qiushi Zhang, Xueqian Yang, Li Yao, Xiaojie Zhao
Working memory (WM) refers to the holding and manipulation of information during cognitive tasks. Its underlying neural mechanisms have been explored through both functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). Trial-by-trial coupling of simultaneously collected EEG and fMRI signals has become an important and promising approach to study the spatio-temporal dynamics of such cognitive processes. Previous studies have demonstrated a modulation effect of the WM load on both the BOLD response in certain brain areas and the amplitude of P3...
January 17, 2017: Neuroscience
https://www.readbyqxmd.com/read/28105459/mog-antibody-positive-benign-unilateral-cerebral-cortical-encephalitis-with-epilepsy
#2
Ryo Ogawa, Ichiro Nakashima, Toshiyuki Takahashi, Kimihiko Kaneko, Tetsuya Akaishi, Yoshiki Takai, Douglas Kazutoshi Sato, Shuhei Nishiyama, Tatsuro Misu, Hiroshi Kuroda, Masashi Aoki, Kazuo Fujihara
OBJECTIVE: To describe the features of adult patients with benign, unilateral cerebral cortical encephalitis positive for the myelin oligodendrocyte glycoprotein (MOG) antibody. METHODS: In this retrospective, cross-sectional study, after we encountered an index case of MOG antibody-positive unilateral cortical encephalitis with epileptic seizure, we tested for MOG antibody using our in-house, cell-based assay in a cohort of 24 consecutive adult patients with steroid-responsive encephalitis of unknown etiology seen at Tohoku University Hospital (2008-2014)...
March 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/28104252/novel-zebrafish-eae-model-a-quick-in-vivo-screen-for-multiple-sclerosis
#3
Pushkar Kulkarni, Swapna Yellanki, Raghavender Medishetti, Dharmarajan Sriram, Uday Saxena, Perumal Yogeeswari
INTRODUCTION: Pre-clinical drug discovery for multiple sclerosis (MS) is a labor intensive activity to perform in rodent models. This is owing to the long duration of disease induction and observation of treatment effects in an experimental autoimmune encephalomyelitis (EAE) model. We propose a novel adult zebrafish based model which offers a quick and simple protocol that can used to screen candidates as a step between in vitro experiments and rodent studies. The experiments conducted for this manuscript were to standardize a suitable model of EAE in adult zebrafish and validate it using known modulators...
January 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28088614/ccaat-enhancer-binding-protein-%C3%AE-promotes-pathogenesis-of-eae
#4
Michelle R Simpson-Abelson, Gerard Hernandez-Mir, Erin E Childs, J Agustin Cruz, Amanda C Poholek, Ansuman Chattopadhyay, Sarah L Gaffen, Mandy J McGeachy
The CCAAT/Enhancer Binding Protein β (C/EBPβ) transcription factor is activated by multiple inflammatory stimuli, including IL-17 and LPS, and C/EBPβ itself regulates numerous genes involved in inflammation. However, the role of C/EBPβ in driving autoimmunity is not well understood. Here, we demonstrate that Cebpb(-/-) mice are resistant to EAE. Cebpb(-/-) mice exhibited reduced lymphocyte and APC infiltration into CNS following EAE induction. Furthermore, MOG-induced Th17 cytokine production was impaired in draining LN, indicating defects in Th17 cell priming...
January 12, 2017: Cytokine
https://www.readbyqxmd.com/read/28069965/dual-role-of-alcam-in-neuroinflammation-and-blood-brain-barrier-homeostasis
#5
Marc-André Lécuyer, Olivia Saint-Laurent, Lyne Bourbonnière, Sandra Larouche, Catherine Larochelle, Laure Michel, Marc Charabati, Michael Abadier, Stephanie Zandee, Neda Haghayegh Jahromi, Elizabeth Gowing, Camille Pittet, Ruth Lyck, Britta Engelhardt, Alexandre Prat
Activated leukocyte cell adhesion molecule (ALCAM) is a cell adhesion molecule found on blood-brain barrier endothelial cells (BBB-ECs) that was previously shown to be involved in leukocyte transmigration across the endothelium. In the present study, we found that ALCAM knockout (KO) mice developed a more severe myelin oligodendrocyte glycoprotein (MOG)35-55-induced experimental autoimmune encephalomyelitis (EAE). The exacerbated disease was associated with a significant increase in the number of CNS-infiltrating proinflammatory leukocytes compared with WT controls...
January 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28057865/cocapture-of-cognate-and-bystander-antigens-can-activate-autoreactive-b-cells
#6
Nicholas S R Sanderson, Maria Zimmermann, Luca Eilinger, Céline Gubser, Nicole Schaeren-Wiemers, Raija L P Lindberg, Stephanie K Dougan, Hidde L Ploegh, Ludwig Kappos, Tobias Derfuss
Autoantibodies against myelin oligodendrocyte glycoprotein (MOG) are associated with autoimmune central nervous system diseases like acute disseminated encephalomyelitis (ADEM). For ADEM, it is speculated that a preceding infection is the trigger of the autoimmune response, but the mechanism connecting the infection to the production of MOG antibodies remains a mystery. We reasoned that the ability of B cells to capture cognate antigen from cell membranes, along with small quantities of coexpressed "bystander" antigens, might enable B-cell escape from tolerance...
January 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28052657/role-of-adjuvant-thoracic-radiation-therapy-and-full-dose-chemotherapy-in-pn2-non-small-cell-lung-cancer-elucidation-based-on-single-institute-experience
#7
Hyojung Park, Dongryul Oh, Yong Chan Ahn, Hongryull Pyo, Jae Myung Noh, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim, Jae Ill Zo, Young Mog Shim
Purpose: The optimal adjuvant therapy modality for treating pN2 non-small cell lung cancer (NSCLC) patients has not yet been established. In this study, the authors investigated clinical outcomes following three different adjuvant therapy modalities. Materials and Methods: From January 2006 to December 2012, 240 patients with cN0/1 disease were found to have pN2 disease following curative resection and received one of three adjuvant therapy modalities: thoracic radiation therapy (TRT) and concurrent chemotherapy (CTx) (CCRT) (Group I); CCRT plus consolidation CTx (Group II); and CTx alone (Group III)...
December 12, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28028151/lrch1-interferes-with-dock8-cdc42-induced-t-cell-migration-and-ameliorates-experimental-autoimmune-encephalomyelitis
#8
Xiaoyan Xu, Lei Han, Guixian Zhao, Shengjie Xue, Yunzhen Gao, Jun Xiao, Shicheng Zhang, Peng Chen, Zhi-Ying Wu, Jianping Ding, Ronggui Hu, Bin Wei, Hongyan Wang
Directional autoreactive CD4(+) T cell migration into the central nervous system plays a critical role in multiple sclerosis. Recently, DOCK8 was identified as a guanine-nucleotide exchange factor (GEF) for Cdc42 activation and has been associated with human mental retardation. Little is known about whether DOCK8 is related to multiple sclerosis (MS) and how to restrict its GEF activity. Using two screening systems, we found that LRCH1 competes with Cdc42 for interaction with DOCK8 and restrains T cell migration...
January 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28011368/co-metal-organic-frameworks-with-pure-uniform-crystal-morphology-prepared-via-co-2-exchange-mediated-transformation-from-zn-metallogels-for-luminol-catalysed-chemiluminescence
#9
Xue Qian Tang, Bo Wen Xiao, Chun Mei Li, Dong Mei Wang, Cheng Zhi Huang, Yuan Fang Li
Cation exchange-mediated transformation from Zn-metallogels (MOGs), which was a mild facile strategy relative to the demanding hydrothermal method, was employed to develop Co(2+) metal-organic frameworks (Co-MOFs) at room temperature. The obtained Co-MOFs was of uniform octahedral morphology and possessed high activity to catalyze luminol chemiluminescence without extra oxidants. By adding cysteine, the CL emission of luminol-Co-MOFs system was further enhanced. Based on this phenomenon, Co-MOFs was utilized to build a practical sensing platform for cysteine determination...
December 15, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28011150/piperlongumine-attenuates-experimental-autoimmune-encephalomyelitis-through-inhibition-of-nf-kappab-activity
#10
Sun Mi Gu, Jaesuk Yun, Dong Ju Son, Hoi Yeong Kim, Kyung Tak Nam, Hae Deun Kim, Min Gi Choi, Jeong Soon Choi, Young Min Kim, Sang-Bae Han, Jin Tae Hong
Multiple sclerosis (MS) is a chronic, autoimmune and neurodegenerative disease in which demyelination sporadically and repeatedly occurs in the central nervous system (CNS). The activity of nuclear factor kappa B (NF-κB), a family of transcription factors, was increased in the cerebrospinal fluid (CSF) and/or the serum and brain and/or spinal cord of MS patients than in a healthy donors. In our study, we investigated whether piperlongumine (PL), which is known to have inhibitory effect on activity of NF-κB, can alleviate an experimental autoimmune encephalomyelitis (EAE)...
December 21, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28011088/nitration-of-mog-diminishes-its-encephalitogenicity-depending-on-mhc-haplotype
#11
Andreas Warnecke, Sravani Musunuri, Marie N'diaye, Tatyana Sandalova, Adnane Achour, Jonas Bergquist, Robert A Harris
Post-translational modifications of autoantigens are hypothesized to affect their immunogenicity. We here report that nitration of tyrosine 40 in Myelin Oligodendrocyte Glycoprotein (MOG) abrogates its encephalitogenicity both at protein and peptide levels in the experimental autoimmune encephalomyelitis (EAE) model in H2(b) C57BL/6 mice. Furthermore, nitrated MOG displays inferior antigen-specific proliferation of 2D2 splenocytes in vitro. Conversely, H2(q) DBA1 mice remain fully susceptible to EAE induction using nitrated MOG as the dominant epitope of H2(q) mice is unaltered...
November 26, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28005176/the-mrz-reaction-as-a-highly-specific-marker-of-multiple-sclerosis-re-evaluation-and-structured-review-of-the-literature
#12
S Jarius, P Eichhorn, D Franciotta, H F Petereit, G Akman-Demir, M Wick, B Wildemann
It has long been known that the majority of patients with multiple sclerosis (MS) display an intrathecal, polyspecific humoral immune response to a broad panel of neurotropic viruses. This response has measles virus, rubella virus and varicella zoster virus as its most frequent constituents and is thus referred to as the MRZ reaction (MRZR). Re-evaluation of the specificity of MRZR as a marker of MS. Structured review of the existing English-, German- and Spanish-language literature on MRZR testing, with evaluation of MRZR in a cohort of 43 unselected patients with MS and other neurological diseases as a proof of principle...
December 22, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27994362/serological-markers-associated-with-neuromyelitis-optica-spectrum-disorders-in-south-india
#13
Lekha Pandit, Douglas Kazutoshi Sato, Sharik Mustafa, Toshiyuki Takahashi, Anitha D'Cunha, Chaithra Malli, Akshatha Sudhir, Kazuo Fujihara
BACKGROUND: Neuromyelitis optica spectrum disorders (NMOSDs) represent 20% of all demyelinating disorders in South India. No studies have determined the seroprevalence to both antibodies against aquaporin-4* and antimyelin oligodendrocyte glycoprotein antibody (anti-MOG+) in this population. OBJECTIVE: To identify and characterize seropositive patients for anti-aquaporin-4 antibody (anti-AQP4+) and anti-MOG+ in South India. MATERIALS AND METHODS: We included 125 consecutive patients (15 children) who were serologically characterized using live transfected cells to human M23-AQP4 or full-length MOG...
October 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27988845/an-updated-histological-classification-system-for-multiple-sclerosis-lesions
#14
Tanja Kuhlmann, Samuel Ludwin, Alexandre Prat, Jack Antel, Wolfgang Brück, Hans Lassmann
Multiple sclerosis is a complex and heterogeneous, most likely autoimmune, demyelinating disease of the central nervous system (CNS). Although a number of histological classification systems for CNS lesions have been used by different groups in recent years, no uniform classification exists. In this paper, we propose a simple and unifying classification of MS lesions incorporating many elements of earlier histological systems that aims to provide guidelines for neuropathologists and researchers studying MS lesions to allow for better comparison of different studies performed with MS tissue, and to aid in understanding the pathogenesis of the disease...
January 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/27988839/dr%C3%AE-1-mog-35-55-reduces-permanent-ischemic-brain-injury
#15
Jianyi Wang, Qing Ye, Jing Xu, Gil Benedek, Haiyue Zhang, Yuanyuan Yang, Huan Liu, Roberto Meza-Romero, Arthur A Vandenbark, Halina Offner, Yanqin Gao
Stroke induces a catastrophic immune response that involves the global activation of peripheral leukocytes, especially T cells. The human leukocyte antigen-DRα1 domain linked to MOG-35-55 peptide (DRα1-MOG-35-55) is a partial major histocompatibility complex (MHC) class II construct which can inhibit neuroantigen-specific T cells and block binding of the cytokine/chemokine macrophage migration inhibitory factor (MIF) to its CD74 receptor on monocytes and macrophages. Here, we evaluated the therapeutic effect of DRα1-MOG-35-55 in a mouse model of permanent distal middle cerebral artery occlusion (dMCAO)...
December 17, 2016: Translational Stroke Research
https://www.readbyqxmd.com/read/27974153/tenascin-c-deficiency-protects-mice-from-experimental-autoimmune-encephalomyelitis
#16
Miljana Momčilović, Vera Stamenković, Miloš Jovanović, Pavle R Andjus, Igor Jakovčevski, Melitta Schachner, Đorđe Miljković
The extracellular matrix glycoprotein tenascin-C (TnC) has been increasingly appreciated as a molecule susceptibly reacting to abnormalities in the mammalian immune system. TnC expression is elevated in inflamed tissues outside the immune system, but also in lymphoid organs. It participates in the promotion of inflammatory responses. Here, the role of TnC in a paradigm of CNS autoimmunity was investigated. Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, was induced in mice deficient in TnC (TnC(-/-) mice)...
January 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27951522/brain-lesion-distribution-criteria-distinguish-ms-from-aqp4-antibody-nmosd-and-mog-antibody-disease
#17
Maciej Juryńczyk, George Tackley, Yazhuo Kong, Ruth Geraldes, Lucy Matthews, Mark Woodhall, Patrick Waters, Wilhelm Kuker, Matthew Craner, Andrew Weir, Gabriele C DeLuca, Stephane Kremer, Maria Isabel Leite, Angela Vincent, Anu Jacob, Jérôme de Sèze, Jacqueline Palace
IMPORTANCE: Neuromyelitis optica spectrum disorders (NMOSD) can present with very similar clinical features to multiple sclerosis (MS), but the international diagnostic imaging criteria for MS are not necessarily helpful in distinguishing these two diseases. OBJECTIVE: This multicentre study tested previously reported criteria of '(1) at least 1 lesion adjacent to the body of the lateral ventricle and in the inferior temporal lobe; or (2) the presence of a subcortical U-fibre lesion or (3) a Dawson's finger-type lesion' in an independent cohort of relapsing-remitting multiple sclerosis (RRMS) and AQP4-ab NMOSD patients and also assessed their value in myelin oligodendrocyte glycoprotein (MOG)-ab positive and ab-negative NMOSD...
October 8, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/27925393/intensive-care-unit-icu-readmission-after-major-lung-resection-prevalence-patterns-and-mortality
#18
Jae Jun Jung, Jong Ho Cho, Tae Hee Hong, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim, Young Mog Shim, Jae Ill Zo
BACKGROUND: The aim of this study was to identify risk factors associated with mortality in patients re-admitted to an intensive care unit (ICU) after initial recovery from major lung resection. METHODS: We retrospectively reviewed the case records of all patients who underwent major lung resection between February 2011 and May 2013. A total of 1916 patients underwent major resection surgery for various lung diseases, 63 (3.3%) of which required ICU admission after initial recovery...
January 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/27923715/imaging-phenotyping-using-radiomics-to-predict-micropapillary-pattern-within-lung-adenocarcinoma
#19
So Hee Song, Hyunjin Park, Geewon Lee, Ho Yun Lee, Insuk Sohn, Hye Seung Kim, Seung Hak Lee, Ji Yun Jeong, Jhingook Kim, Kyung Soo Lee, Young Mog Shim
INTRODUCTION: Lung adenocarcinoma (ADC) with micropapillary pattern have been reported to have a poor prognosis. However, few studies have reported on the imaging-based identification of micropapillary component, which were all subjective studies dealing with qualitative CT variables. We aimed to explore imaging phenotyping using a radiomics approach for predicting micropapillary pattern within lung ADC METHODS: We enrolled 339 patients who underwent complete resection for lung ADC. Histologic subtypes and grades of the ADCs were classified...
December 3, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27923573/the-impacts-of-selective-logging-and-clear-cutting-on-woody-plant-diversity-after-40years-of-natural-recovery-in-a-tropical-montane-rain-forest-south-china
#20
Yi Ding, Runguo Zang, Xinghui Lu, Jihong Huang
Historically, clear-cutting and selective logging have been the commercial logging practices. However, the effect of these pervasive timber extraction methods on biodiversity in tropical forests is still poorly understood. In this study, we compared abiotic factors, species diversity, community composition, and structure between ca. 40-year-old clear-cut (MCC); ca. 40-year-old selectively logged (MSL); and tropical old growth montane rain forests (MOG) on Hainan Island, China. Results showed that there were a large number of trees with a diameter at breast height (DBH) <30cm in the two logged forests...
February 1, 2017: Science of the Total Environment
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