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Ghadah Alnosair, Khalid A Alanazi, Fatima I Alhumaid, Bayan S Alshuhayb
Multiple sclerosis (MS) is the most common demyelinating disease affecting the central nervous system. It has a wide range of manifestations and commonly affects the visual system. Many patients with MS report decreased vision, diplopia, nystagmus, and abnormal ocular motility. Nevertheless, bilateral horizontal gaze palsies are exceptionally rarely seen. We present the case of a 24-year-old female who came to our pediatric ophthalmology clinic complaining of bilateral horizontal gaze palsy, photophobia, and eye pain for 2 days...
2024: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
#2
JOURNAL ARTICLE
Juho Laaksonen, Ville Ponkilainen, Ilari Kuitunen, Julius Möttönen, Ville M Mattila
OBJECTIVE: Examine the link between pediatric traumatic brain injury (pTBI) and early-onset multiple sclerosis in Finland. METHODS: Conducted nationwide register study (1998-2018) with 28,750 pTBI patients (< 18) and 38,399 pediatric references with extremity fractures. Multiple sclerosis diagnoses from Finnish Social Insurance Institution. Employed Kaplan-Meier and multivariable Cox regression for probability assessment, results presented with 95% CI. RESULTS: Of 66 post-traumatic multiple sclerosis cases, 30 (0...
April 2024: Brain and Behavior
#3
JOURNAL ARTICLE
Jennifer Cervantes, Jenna Wallace, Annie Kennelly Helms, Elizabeth A Diekroger, Jason Fogler
Layla is a 6.7-year-old girl diagnosed with attention-deficit/hyperactivity disorder (ADHD)-predominantly hyperactive/impulsive type-delayed adaptive skills, enuresis, unspecified malnutrition, and feeding difficulties. She presented to developmental-behavioral pediatrics (DBP) in January 2022 due to caregiver concerns for autism spectrum disorder (ASD).Layla lives in a polyamorous family with her biological mother and father, mother's partner whom Layla refers to as her uncle, and her 2 half-siblings. There is a maternal history of special education services, schizoaffective disorder, bipolar disorder, multiple sclerosis, Wolff-Parkinson-White syndrome, and ADHD...
March 2024: Journal of Developmental and Behavioral Pediatrics: JDBP
#4
JOURNAL ARTICLE
Tanuja Chitnis, Brenda Banwell, Ludwig Kappos, Douglas L Arnold, Kivilcim Gücüyener, Kumaran Deiva, Stephane Saubadu, Wenruo Hu, Myriam Benamor, Annaig Le-Halpere, Philippe Truffinet, Marc Tardieu
BACKGROUND: The double-blind TERIKIDS study demonstrated the efficacy and safety of teriflunomide. OBJECTIVE: To evaluate the efficacy, safety, and tolerability of continuous teriflunomide treatment in the TERIKIDS open-label extension. METHODS: In the double-blind period, children with relapsing MS were randomized to placebo or teriflunomide (14 mg adult-equivalent dose) for ⩽ 96 weeks. Participants received teriflunomide for ⩽ 192 weeks post-randomization in the open-label extension...
April 15, 2024: Multiple Sclerosis: Clinical and Laboratory Research
#5
Han Grezenko, Imam A Shah, Astri Anindya Sariza, Amna B Baluch, Ateesh Kumar, Muhammad Abubakar
This case report presents an atypical instance of pediatric-onset multiple sclerosis (MS) in a 12-year-old male, a demographic less commonly affected by this condition. The patient's clinical course was marked by severe and progressive symptoms, including lower limb weakness and loss of bowel/bladder control, diverging from the typical relapsing-remitting pattern observed in pediatric MS. Despite initial resistance to high-dose steroid treatment, his condition was ultimately stabilized through plasmapheresis, following the detection of myelin oligodendrocyte glycoprotein antibodies...
March 2024: Curēus
#6
JOURNAL ARTICLE
Ali Nikkhah, Mohammad Mahdi Nasehi, Nader Momtazmanesh, Kourosh Etemad, Somayeh Hajatnia
OBJECTIVES: Therapeutic plasma exchange (TPE) is a plasmapheresis procedure whose Safety data for pediatric neuro-immunological disorders (PNID) is confined. The present research documents TPE's safety and feasibility data in these conditions. MATERIALS & METHODS: The current study involved six distinct groups of patients with PNID undergoing TPE: neuromyelitis optic spectrum disorder (NMOSD), autoimmune encephalitis (AIE), acute disseminated encephalomyelitis (ADEM), multiple sclerosis (MS), Guillain-Barre syndrome (GBS), and optic neuritis (ON)...
2024: Iranian Journal of Child Neurology
#7
JOURNAL ARTICLE
Farzan Kianersi, Hamidreza Kianersi, Mohsen Pourazizi, Afsaneh Naderi Beni, Pegah Noorshargh
Fuchs Uveitis Syndrome (FUS), also known as Fuchs Heterochromic Iridocyclitis, is a chronic form of uveitis characterized by mild inflammation primarily affecting one eye. This study aimed to investigate the clinical and epidemiological features of FUS in an Iranian population. A retrospective analysis was conducted on 466 patients diagnosed with FUS at an ophthalmology center affiliated with Isfahan University of Medical Sciences between 2003 and 2021. The Kimura et al. criteria were used for FUS diagnosis...
April 14, 2024: Scientific Reports
#8
JOURNAL ARTICLE
Sama Bitarafan, Feng Zhu, Ali Mirza, Charles N Bernstein, Gary Van Domselaar, Ruth Ann Marrie, E Ann Yeh, Yinshan Zhao, Brenda Banwell, Emmanuelle Waubant, Helen Tremlett
OBJECTIVE: To compare diet and the modified dietary inflammatory index (mDII) between individuals with pediatric-onset multiple sclerosis (PoMS), monophasic acquired demyelinating syndromes (monoADS), and controls. METHODS: The association between diet, mDII, and disease status was examined in 131 individuals with PoMS/monoADS/controls (38/45/48) using logistic regression. RESULTS: The associations between diet and PoMS were modest, reaching significance for whole grain intake (adjusted odds ratio, aOR=0...
April 4, 2024: Multiple Sclerosis and related Disorders
#9
Smaran S Teru, Jaswanthi Dogiparthi, Thomas J Bonitz, Chris Buzas
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a newly discovered autoimmune demyelinating disorder. The clinical manifestations of MOGAD are divergent but often characterized by inflammatory central nervous system (CNS) deficits such as optic neuritis, encephalitis, or transverse myelitis that predominantly affect the pediatric population. Despite the distinct features often associated with MOGAD, the disease exhibits a diverse range of clinical manifestations, making timely diagnosis and treatment challenging...
March 2024: Curēus
#10
JOURNAL ARTICLE
Cem Evereklioglu, Tülay Karacan Erşekerci, Hatice Kübra Sönmez, Hidayet Sener, Duygu Gulmez Sevim, Osman Ahmet Polat, Hatice Arda, Fatih Horozoglu
Purpose To determine the etiology and anatomic localization of uveitis, the frequency of intraocular pressure (IOP) elevation, and the type of secondary glaucoma and to assess the medical, surgical, and postoperative complications in adult and pediatric patients with acute or chronic uveitis. Methods A total of 307 eyes of 186 patients who were followed up in the Uvea-Behçet Unit of the Ophthalmology Department, Erciyes University, Turkey, were included in the study. Demographic, ocular, and systemic data were recorded; ophthalmological examinations were performed; and recurrences and complications of uveitis were identified...
March 2024: Curēus
#11
Ula Arkar, Tina Vipotnik Vesnaver, Damjan Osredkar, Mirjana Perković Benedik, Neli Bizjak
Pediatric onset multiple sclerosis (POMS) in the very young is a very rare entity and presents a difficult diagnostic challenge due to overlapping signs and symptoms with other diseases. We present a 4-year-old boy who initially presented with right-sided hemiparesis and demyelinating lesions on MRI. Follow-up MRI examinations 3 and 6 months later revealed new demyelinating lesions. Ten months after initial presentation, he presented with right-sided hemiparesis, central facial nerve palsy on the right side and new demyelinating lesions on MRI...
2024: Frontiers in Neurology
#12
JOURNAL ARTICLE
Naila Makhani, Christine Lebrun-Frenay, Aksel Siva, Veronika Shabanova, Evangeline Wassmer, Jonathan D Santoro, Sona Narula, J Nicholas Brenton, Soe Mar, Francoise Durand-Dubief, Helene Zephir, Guillaume Mathey, Juan I Rojas, Jerome de Seze, Silvia Tenembaum, Robert Thompson Stone, Olivier Casez, Clarisse Carra-Dallière, Rinze F Neuteboom, Nusrat Ahsan, Hugo A Arroyo, Philippe Cabre, Grace Gombolay, Matilde Inglese, Celine Louapre, Monica Margoni, Filipe Palavra, Daniela Pohl, Daniel S Reich, Aurélie Ruet, Eric Thouvenot, Niklas Timby, Mar Tintore, Ugur Uygunoglu, Wendy Vargas, Sunita Venkateswaran, Helene Verhelst, Ronny Wickstrom, Christina J Azevedo, Orhun Kantarci, Eugene D Shapiro, Darin T Okuda, Daniel Pelletier
BACKGROUND: Cerebrospinal fluid (CSF) and spinal MRIs are often obtained in children with the radiologically isolated syndrome (RIS) for diagnosis and prognosis. Factors affecting the frequency and timing of these tests are unknown. OBJECTIVE: To determine whether age or sex were associated with (1) having CSF or spinal MRI obtained or (2) the timing of these tests. METHODS: We analyzed children (≤ 18 y) with RIS enrolled in an international longitudinal study...
April 2, 2024: Journal of Neurology
#13
JOURNAL ARTICLE
Miguel Leal Rato, Bo Chen, Anna Francis, Silvia Messina, Madalina Miron, Yvonne Sharawakanda, Eoin O'Sullivan, Sarah Cooper, Leonora Fisniku, Christopher Halfpenny, Roswell Martin, Jeremy Hobart, Waqar Rashid, Cheryl Hemingway, Victoria Williams, Yael Hacohen, Ruth Dobson, Sithara Ramdas, Maria Isabel Leite, Jacqueline Palace, Ruth Geraldes
BACKGROUND: Neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are rare disorders often seen in highly specialized services or tertiary centres. We aimed to assess if cohort characteristics depend on the origin of the referral catchment areas serviced by our centre (i.e. local, regional or national). METHODS: Retrospective cohort study using a national referral service database including local (Oxfordshire), regional (Oxfordshire and neighbouring counties), and national patients...
March 14, 2024: Multiple Sclerosis and related Disorders
#14
JOURNAL ARTICLE
Veniamin Y Sidorov, Tatiana N Sidorova, Philip C Samson, Ronald S Reiserer, Clayton M Britt, M Diana Neely, Kevin C Ess, John P Wikswo
The implementation of three-dimensional tissue engineering concurrently with stem cell technology holds great promise for in vitro research in pharmacology and toxicology and modeling cardiac diseases, particularly for rare genetic and pediatric diseases for which animal models, immortal cell lines, and biopsy samples are unavailable. It also allows for a rapid assessment of phenotype-genotype relationships and tissue response to pharmacological manipulation. Mutations in the TSC1 and TSC2 genes lead to dysfunctional mTOR signaling and cause tuberous sclerosis complex (TSC), a genetic disorder that affects multiple organ systems, principally the brain, heart, skin, and kidneys...
February 28, 2024: Bioengineering
#15
JOURNAL ARTICLE
Ruby Ross, Rachel Kenney, Laura J Balcer, Steven L Galetta, Lauren Krupp, Kimberly A O'Neill, Scott N Grossman
BACKGROUND: Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) is a demyelinating disorder that most commonly presents with optic neuritis (ON) and affects children more often than adults. We report 8 pediatric patients with MOG-associated ON and characterize focal optical coherence tomography (OCT) abnormalities over time that help distinguish this condition from the trajectories of other demyelinating disorders. These OCT findings are examined in the context of longitudinal visual function testing...
March 25, 2024: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
#16
Angelo Ghezzi, R F Neuteboom
No abstract text is available yet for this article.
March 18, 2024: Neurology and Therapy
#17
JOURNAL ARTICLE
Fereshteh Ashtari, Aryan Kavosh, Seyed Mohammad Baghbanian, Nahid Hosseini Nejad Mir, Samaneh Hosseini, Nazanin Razazian, Nastaran Majdinasab, Ziba Farajzadegan, Vahid Shaygannejad, Iman Adibi, Sharareh Eskandarieh, Mohammad Ali Sahraian
OBJECTIVE: The relationship between MS and ethnicity has been understudied in the Middle East compared to the United States and Europe. As Iran as the highest prevalence of MS in the Middle East, we decided to investigate the demographic and clinical differences in people with MS (pwMS) from major ethnicities Iran. METHODS: In a cross-sectional study using data from National Multiple Sclerosis Registry in Iran. PwMS from six provinces were chosen and interviewed for determining their ethnicity...
March 2, 2024: Clinical Neurology and Neurosurgery
#18
JOURNAL ARTICLE
Alexandra B Kornbluh, Victor M Campano, Claire Har, Pallavi Dwivedi, William Suslovic, Leigh Sepeta, Ilana Kahn
BACKGROUND: Eosinophils in cerebrospinal fluid (CSF) are an uncommon finding most often associated with parasitic infections, but have also been described in some neuroinflammatory disorders. Eosinophilic infiltration is not thought to be a typical feature of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). We aim to describe the rate of CSF eosinophil positivity in a cohort of pediatric MOGAD patients. METHODS: Single-center retrospective chart review of pediatric MOGAD patients...
March 9, 2024: Multiple Sclerosis and related Disorders
#19
JOURNAL ARTICLE
Monica Margoni, Elisabetta Pagani, Alessandro Meani, Paolo Preziosa, Damiano Mistri, Mor Gueye, Lucia Moiola, Massimo Filippi, Maria Assunta Rocca
OBJECTIVE: The aim of this study was to investigate whether, compared to pediatric healthy controls (HCs), the glymphatic system is impaired in pediatric multiple sclerosis (MS) patients according to their cognitive status, and to assess its association with clinical disability and MRI measures of brain structural damage. METHODS: Sixty-five pediatric MS patients (females = 62%; median age = 15.5 [interquartile range, IQR = 14...
March 13, 2024: Annals of Neurology
#20
JOURNAL ARTICLE
Li Yen Ng, Jonathan McGuinness, Terence Prendiville, Orla Franklin, Mark Walsh, Damien Kenny, Lars Nolke, Colin J McMahon
Cardiac rhabdomyomas are the most common benign pediatric heart tumor in infancy, which are commonly associated with tuberous sclerosis complex (TSC). Most rhabdomyomas are asymptomatic and spontaneously regress over time. However, some cases especially in neonates or small infants can present with hemodynamic instability. Surgical resection of the tumor, which has been the gold standard in alleviating obstruction, is not always possible and may be associated with significant morbidity and mortality. Recently, mammalian target of rapamycin inhibitors (mTORi) have been shown to be safe and effective in the treatment of TSC...
March 13, 2024: Pediatric Cardiology
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