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Myelin oligodendrocyte antibodies

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https://www.readbyqxmd.com/read/29913011/anti-myelin-oligodendrocyte-glycoprotein-antibody-associated-central-nervous-system-demyelination-a-novel-disease-entity
#1
Martin S Weber, Tobias Derfuss, Wolfgang Brück
No abstract text is available yet for this article.
June 18, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29876600/-diagnosis-of-multiple-sclerosis-revision-of-the-mcdonald-criteria-2017
#2
REVIEW
O Aktas, M P Wattjes, M Stangel, H-P Hartung
Multiple sclerosis (MS) is the most common chronic autoimmune disorder of the central nervous system (CNS) largely affecting young adults. The diagnosis of MS is based on two pillars: 1) detection of the spatial and temporal dissemination of focal neurological deficits and 2) exclusion of important differential diagnoses. The current revision of the diagnostic criteria (McDonald 2017) also follows these principles, takes new data on magnetic resonance imaging (MRI) into account and reintroduces the role of cerebrospinal fluid (CSF) diagnostics for relapsing-remitting forms...
June 6, 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29875186/csf-cytokine-profile-in-mog-igg-neurological-disease-is-similar-to-aqp4-igg-nmosd-but-distinct-from-ms-a-cross-sectional-study-and-potential-therapeutic-implications
#3
Kimihiko Kaneko, Douglas Kazutoshi Sato, Ichiro Nakashima, Ryo Ogawa, Tetsuya Akaishi, Yoshiki Takai, Shuhei Nishiyama, Toshiyuki Takahashi, Tatsuro Misu, Hiroshi Kuroda, Satoru Tanaka, Kyoichi Nomura, Yuji Hashimoto, Dagoberto Callegaro, Lawrence Steinman, Kazuo Fujihara, Masashi Aoki
OBJECTIVE: To evaluate cerebrospinal fluid (CSF) cytokine profiles in myelin oligodendrocyte glycoprotein IgG-positive (MOG-IgG+) disease in adult and paediatric patients. METHODS: In this cross-sectional study, we measured 27 cytokines in the CSF of MOG-IgG+ disease in acute phase before treatment (n=29). The data were directly compared with those in aquaporin-4 antibody-positive (AQP4-IgG+) neuromyelitis optica spectrum disorder (NMOSD) (n=20), multiple sclerosis (MS) (n=20) and non-inflammatory controls (n=14)...
June 6, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29788018/brain-immunohistopathology-in-a-patient-with-autoimmune-glial-fibrillary-acidic-protein-astrocytopathy
#4
Yaqing Shu, Youming Long, Yanyu Chang, Rui Li, Xiaobo Sun, Yuge Wang, Yinong Huang, Jing Li, Jianning Chen, Yu Yang, Zhengqi Lu, Xueqiang Hu, Allan G Kermode, Wei Qiu
BACKGROUND: Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a novel meningoencephalomyelitis. However, the pathogenesis of this disease is unclear. We therefore examined a brain biopsy from a patient with autoimmune GFAP astrocytopathy by immunohistopathology. METHODS: We examined brain biopsy sections from a patient with autoimmune GFAP astrocytopathy using hematoxylin and eosin (HE) and Luxol fast blue (LFB) staining, and immunostaining with antibodies for CD4, CD8, CD3, CD20, CD68, CD138, Neu-N, GFAP, myelin oligodendrocyte glycoprotein (MOG), and aquaporin-4 (AQP4)...
May 22, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29778487/clinical-characteristics-of-pediatric-optic-neuritis-with-myelin-oligodendrocyte-glycoprotein-seropositive-a-cohort-study
#5
Qian Chen, Guixian Zhao, Yongheng Huang, Zhenxin Li, Xinghuai Sun, Ping Lu, Yan San, Min Wang, Guohong Tian
BACKGROUND: The clinical characteristics of patients with pediatric optic neuritis with seropositive myelin oligodendrocyte glycoprotein antibodies in Asia have not been reported. METHODS: Patients ≤18 years old with acute onset optic neuritis were enrolled. Serum myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies were detected and patients were followed-up for at least six months. The clinical features were evaluated among myelin oligodendrocyte glycoprotein-seropositive optic neuritis, aquaporin-4-seropositive optic neuritis, and double seronegative optic neuritis...
March 13, 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29755396/overlapping-autoimmune-syndromes-in-patients-with-glial-fibrillary-acidic-protein-antibodies
#6
Xinguang Yang, Huiming Xu, Meilin Ding, Qingmei Huang, Baikeng Chen, Huacai Yang, Tianni Liu, Youming Long, Cong Gao
Background: Glial fibrillary acidic protein (GFAP) astrocytopathy, an autoimmune central nervous system disorder with a specific GFAP-IgG, often coexists with other antibodies. Objective: The aim of this article was to study overlapping syndromes in autoimmune GFAP astrocytopathy. Methods: Antibody was detected by indirect immunofluorescence assay. Patient data were analyzed retrospectively. Results: Thirty patients with positive GFAP-IgG were included, of whom 10 were defined as overlapping syndrome...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29741120/late-onset-neutropenia-and-neurological-relapse-during-long-term-rituximab-therapy-in-myelin-oligodendrocyte-glycoprotein-antibody-spectrum-disorder
#7
Damien Biotti, Fleur Lerebours, Fabrice Bonneville, Jonathan Ciron, Michel Clanet, David Brassat
Late-onset neutropenia after rituximab therapy (LONART) is defined as a fall in the absolute neutrophil count below 500/mm3 at least 3 weeks after rituximab infusion, in the absence of any other explanation. LONART is rare during dysimmune conditions but can be life-threatening. We report on two patients with LONART and associated neurological relapse occurring in myelin oligodendrocyte glycoprotein (MOG)-antibody spectrum disorders. Rituximab was reintroduced in one patient, while the second patient was switched to tocilizumab...
May 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29724224/mog-encephalomyelitis-international-recommendations-on-diagnosis-and-antibody-testing
#8
REVIEW
S Jarius, F Paul, O Aktas, N Asgari, R C Dale, J de Seze, D Franciotta, K Fujihara, A Jacob, H J Kim, I Kleiter, T Kümpfel, M Levy, J Palace, K Ruprecht, A Saiz, C Trebst, B G Weinshenker, B Wildemann
Over the past few years, new-generation cell-based assays have demonstrated a robust association of autoantibodies to full-length human myelin oligodendrocyte glycoprotein (MOG-IgG) with (mostly recurrent) optic neuritis, myelitis and brainstem encephalitis, as well as with acute disseminated encephalomyelitis (ADEM)-like presentations. Most experts now consider MOG-IgG-associated encephalomyelitis (MOG-EM) a disease entity in its own right, immunopathogenetically distinct from both classic multiple sclerosis (MS) and aquaporin-4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorders (NMOSD)...
May 3, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29721683/pediatric-neuromyelitis-optica-spectrum-disorders
#9
REVIEW
Grace Y Gombolay, Tanuja Chitnis
PURPOSE OF REVIEW: Neuromyelitis optica spectrum disorders (NMOSDs) are a group of inflammatory and demyelinating disorders of the central nervous system that can occur in children and adults. The classic presentation of NMOSD is characterized by optic neuritis and transverse myelitis, but other presentations are also recognized, expanding the disease as NMO spectrum disorders. The purpose of this review is to discuss the clinical features, along with management and treatment options, including potential future therapeutic options, in pediatric NMOSD...
May 2, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29710020/-a-15-year-old-girl-with-congenital-cytomegalovirus-infection-presenting-with-sensorineural-hearing-impairment-and-cerebral-while-matter-lesions-but-no-intellectual-disability
#10
Keiichi Nakagawa, Masato Kadoya, Hiroshi Matsumoto, Hiroyuki Moriuchi, Katsunori Ikewaki, Kenichi Kaida
A 15-year-old girl presented with non-progressive sensorineural hearing impairment in her right ear since her early childhood. She had normal intellectual development. When she was 15 years old, small deep white matter lesions around the lateral ventricles were incidentally detected in brain MRI studies through further investigation of auditory organs. Laboratory data including cerebrospinal fluid analysis and antibodies to aquaporin-4 or myelin-oligodendrocyte glycoprotein were normal. She was diagnosed as a congenital cytomegalovirus (CMV) infection based on the detection of CMV DNA from preserved umbilical cord tissue by real-time polymerase chain reaction...
April 28, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29695592/clinical-spectrum-and-prognostic-value-of-cns-mog-autoimmunity-in-adults-the-mogador-study
#11
Alvaro Cobo-Calvo, Anne Ruiz, Elisabeth Maillart, Bertrand Audoin, Helene Zephir, Bertrand Bourre, Jonathan Ciron, Nicolas Collongues, David Brassat, Francois Cotton, Caroline Papeix, Francoise Durand-Dubief, David Laplaud, Romain Deschamps, Mikaël Cohen, Damien Biotti, Xavier Ayrignac, Caroline Tilikete, Eric Thouvenot, Bruno Brochet, Cecile Dulau, Thibault Moreau, Ayman Tourbah, Pierre Lebranchu, Laure Michel, Christine Lebrun-Frenay, Alexis Montcuquet, Guillaume Mathey, Marc Debouverie, Jean Pelletier, Pierre Labauge, Nathalie Derache, Marc Coustans, Fabien Rollot, Jérôme De Seze, Sandra Vukusic, Romain Marignier
OBJECTIVE: To describe clinical and radiologic features associated with myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) in a large French nationwide adult cohort, to assess baseline prognostic features of MOG-Ab-associated diseases after a first acute demyelinating syndrome, and to evaluate the clinical value of MOG-Ab longitudinal analysis. METHODS: Clinical data were obtained from 197 MOG-Ab-positive patients ≥18 years of age. Complete imaging data were available in 108, and 54 serum samples were eligible for longitudinal evaluation...
May 22, 2018: Neurology
https://www.readbyqxmd.com/read/29690837/neutralization-of-interleukin-1%C3%AE-following-diffuse-traumatic-brain-injury-in-the-mouse-attenuates-the-loss-of-mature-oligodendrocytes
#12
Johanna Flygt, Karsten Ruscher, Amanda Norberg, Anis Mir, Hermann Gram, Fredrik Clausen, Niklas Marklund
Traumatic brain injury (TBI) commonly results in injury to the components of the white matter tracts, causing post-injury cognitive deficits. The myelin-producing oligodendrocytes (OLs) are vulnerable to TBI although may plausibly be replaced by proliferating oligodendrocyte progenitor cells (OPCs). The cytokine interleukin-1β (IL-1β) is a key mediator of the complex inflammatory response, and when neutralized in experimental TBI behavioral outcome was improved. To evaluate the role of IL-1β on OL cell death and OPC proliferation, 116 adult male mice subjected to sham injury or the central fluid percussion injury (cFPI) model of traumatic axonal injury, were analyzed at 2, 7 and 14 days post-injury...
April 25, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29685427/neuromyelitis-optica-spectrum-disorders-features-of-aquaporin-4-myelin-oligodendrocyte-glycoprotein-and-double-seronegative-mediated-subtypes
#13
REVIEW
C Alves Do Rego, N Collongues
The new diagnostic classification of neuromyelitis optica spectrum disorder (NMOSD) in 2015 highlights the central role of biomarkers, such as antibodies against aquaporin-4 (AQP4-Ab), in diagnosis. Also, in approximately 20-25% of patients without AQP4-Ab (NMOSDAQP4- ) the presence of an antibody directed against myelin oligodendrocyte glycoprotein (MOG) characterizes a specific population of NMOSD patients (NMOSDMOG+ ), according to their demographic and clinical data and prognoses. While double-seronegative cases (NMOSDNEG ) have not been fully described, they may correspond to the very first patients with opticospinal demyelination reported by Devic and Gault in 1894...
June 2018: Revue Neurologique
https://www.readbyqxmd.com/read/29685293/anti-il-6-receptor-antibody-improves-pain-symptoms-in-mice-with-experimental-autoimmune-encephalomyelitis
#14
Kenichi Serizawa, Haruna Tomizawa-Shinohara, Mayu Magi, Kenji Yogo, Yoshihiro Matsumoto
BACKGROUND AND AIMS: Chronic pain is a prevalent symptom in patients with autoimmune encephalomyelitis such as multiple sclerosis and neuromyelitis optica. Although IL-6 is involved in various inflammatory and immune diseases, the roles of IL-6 in autoimmune-related pain have not been clarified. Therefore, we examined the effect of anti-IL-6 receptor antibody (MR16-1) on the pain sensitivity of experimental autoimmune encephalomyelitis (EAE) mice. MATERIALS AND METHODS: EAE was induced in female C57BL/6J mice by subcutaneous immunization with myelin oligodendrocyte glycoprotein 35-55 emulsified in adjuvant (Day 0)...
June 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29670575/mog-igg-associated-optic-neuritis-encephalitis-and-myelitis-lessons-learned-from-neuromyelitis-optica-spectrum-disorder
#15
REVIEW
Giordani Rodrigues Dos Passos, Luana Michelli Oliveira, Bruna Klein da Costa, Samira Luisa Apostolos-Pereira, Dagoberto Callegaro, Kazuo Fujihara, Douglas Kazutoshi Sato
Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been found in some cases diagnosed as seronegative neuromyelitis optica spectrum disorder (NMOSD). MOG-IgG allowed the identification of a subgroup with a clinical course distinct from that of NMOSD patients who are seropositive for aquaporin-4-IgG antibodies. MOG-IgG is associated with a wider clinical phenotype, not limited to NMOSD, with the majority of cases presenting with optic neuritis (ON), encephalitis with brain demyelinating lesions, and/or myelitis...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29661590/rituximab-was-effective-for-acute-disseminated-encephalomyelitis-followed-by-recurrent-optic-neuritis-with-anti-myelin-oligodendrocyte-glycoprotein-antibodies
#16
Masako Nagashima, Hitoshi Osaka, Takahiro Ikeda, Ayumi Matsumoto, Akihiko Miyauchi, Kimihiko Kaneko, Ichiro Nakashima, Yuko Nakano, Kei Wakabayashi, Yukifumi Monden, Takanori Yamagata
BACKGROUND: The effect of rituximab on acute disseminated encephalomyelitis (ADEM) followed by recurrent optic neuritis (ON) is not yet known. PATIENT: We are reporting the case of a 4-year-old Japanese girl who was diagnosed with anti-myelin oligodendrocyte glycoprotein (MOG) antibody positive ADEM followed by recurrent ON. She developed altered mental status, left facial paralysis, left paresis, and experienced three episodes of ON. She was treated with rituximab and azathioprine (AZA) as prevention for recurrent ON...
April 13, 2018: Brain & Development
https://www.readbyqxmd.com/read/29661538/an-unusual-case-of-anti-mog-cns-demyelination-with-concomitant-mild-anti-nmdar-encephalitis
#17
Jiajia Zhou, Winwen Tan, Suyin Elaine Tan, Jing Hu, Zhongqin Chen, Kang Wang
We report the case of a patient who presented with progressive unsteadiness and narcoleptic attacks followed by behavioral change and psychosis, without visual disturbances or seizures. MRI revealed multiple areas of fluid attenuation inversion recovery (FLAIR) high-intensity lesions involving the cerebellum, brainstem, thalamus and third ventricular peri-ependymal region consistent with demyelination. Both the serum myelin oligodendrocyte glycoprotein-antibodies (MOG-Abs) and cerebral spinal fluid (CSF) anti-N-methyl-d-as-partate receptor (NMDAR) antibodies were positive using transfected cell based assays...
July 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29649469/phosphatidylserine-is-not-just-a-cleanup-crew-but-also-a-well-meaning-teacher
#18
Fiona Y Glassman, Jennifer L Schneider, Radha Ramakrishnan, Robert K Dingman, Murali Ramanathan, Richard B Bankert, Sathy V Balu-Iyer
Phosphatidylserine (PS) exposure during apoptosis leads to silent clearance of cells without adverse immune reactions to self-proteins. Given the biological functions of PS in cellular cleanup and global immunosuppression, we hypothesized that administration of PS-protein complexes would reduce immunogenicity. Here, we report that exposing Pompe disease mice to acid alpha glucosidase (rhGAA) with PS or immunosuppressant dexamethasone resulted in lower anti-rhGAA antibodies than in animals receiving rhGAA alone...
April 9, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29629942/paediatric-multiple-sclerosis-and-other-acute-demyelinating-diseases
#19
Kevin Rostásy, Barbara Bajer-Kornek
PURPOSE OF REVIEW: Neuroimmunological diseases encompass a wide spectrum of diseases in children. Apart from the discovery of autoantibodies affecting primarily grey matter structures and the improved clinical characterization of rare entities such as N-methyl D-aspartate receptor-R- encephalitis, important strides have also been made in autoimmune-mediated white matter diseases, including paediatric multiple sclerosis (pedMS) and other acute demyelinating syndromes (ADS) often associated with antibodies (abs) against myelin-oligodendrocyte-glycoprotein (MOG)...
June 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29623106/defining-distinct-features-of-anti-mog-antibody-associated-central-nervous-system-demyelination
#20
REVIEW
Martin S Weber, Tobias Derfuss, Imke Metz, Wolfgang Brück
Extensive research over the last decades basically failed to identify a common cause of noninfectious inflammatory central nervous system (CNS) demyelinating disease. To a great extent, this may reflect that the group of inflammatory CNS demyelinating disorders likely contains multiple pathogenetically distinct disease entities. Indeed, the greatest success so far in deciphering the pathogenesis of a CNS demyelinating disorder resulted from the discovery of anti-aquaporin (AQP)-4 antibodies (ab), which allowed progressive delineation of neuromyelitis optica (NMO), formerly considered a variant of the most common CNS demyelinating disorder, multiple sclerosis (MS), as a distinct disease...
2018: Therapeutic Advances in Neurological Disorders
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