Robert Balk, Annette M Esper, Greg S Martin, Russell R Miller, Bert K Lopansri, John P Burke, Mitchell Levy, Steven Opal, Richard E Rothman, Franco R D'Alessio, Venkataramana K Sidhaye, Neil R Aggarwal, Jared A Greenberg, Mark Yoder, Gourang Patel, Emily Gilbert, Jorge P Parada, Majid Afshar, Jordan A Kempker, Tom van der Poll, Marcus J Schultz, Brendon P Scicluna, Peter M C Klein Klouwenberg, Janice Liebler, Emily Blodget, Santhi Kumar, Krupa Navalkar, Thomas D Yager, Dayle Sampson, James T Kirk, Silvia Cermelli, Roy F Davis, Richard B Brandon
(1) Background: SeptiCyte RAPID is a molecular test for discriminating sepsis from non-infectious systemic inflammation, and for estimating sepsis probabilities. The objective of this study was the clinical validation of SeptiCyte RAPID, based on testing retrospectively banked and prospectively collected patient samples. (2) Methods: The cartridge-based SeptiCyte RAPID test accepts a PAXgene blood RNA sample and provides sample-to-answer processing in ~1 h. The test output (SeptiScore, range 0-15) falls into four interpretation bands, with higher scores indicating higher probabilities of sepsis...
February 20, 2024: Journal of Clinical Medicine