Yuta Okabe, Nobuyuki Murakoshi, Nagomi Kurebayashi, Hana Inoue, Yoko Ito, Takashi Murayama, Chika Miyoshi, Hiromasa Funato, Koichiro Ishii, Dongzhu Xu, Kazuko Tajiri, Rujie Qin, Kazuhiro Aonuma, Yoshiko Murakata, Zonghu Song, Shigeharu Wakana, Utako Yokoyama, Takashi Sakurai, Kazutaka Aonuma, Masaki Ieda, Masashi Yanagisawa
Inherited arrhythmia syndromes (IASs) can cause life-threatening arrhythmias and are responsible for a significant proportion of sudden cardiac deaths (SCDs). Despite progress in the development of devices to prevent SCDs, the precise molecular mechanisms that induce detrimental arrhythmias remain to be fully investigated, and more effective therapies are desirable. In the present study, we screened a large-scale randomly mutagenized mouse library by electrocardiography to establish a disease model of IASs and consequently found one pedigree that exhibited spontaneous ventricular arrhythmias (VAs) followed by SCD within 1 y after birth...
April 23, 2024: Proceedings of the National Academy of Sciences of the United States of America