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pethidine adult dose

V Ayatollahi, S Dehghanpour Farashah, S Behdad, S Vaziribozorg, M Rabbani Anari
BACKGROUND: Postoperative pain is a common problem in hospitals. Adults undergoing uvulopalatopharyngoplasty (UPPP) with tonsillectomy experience an unacceptable level of intense postoperative pain, especially during the first 24 h after surgery. This study investigated the analgesic effects of vitamin C in patients undergoing UPPP and tonsillectomy. METHOD: This study was done on forty patients that were evaluated in a randomised double-blinded clinical trial. Patients included in the study were within the age range of 25-50 years with BMI<35, physical status I,II according to the American Society of Anesthesia (ASA) and who underwent uvulopalatopharyngoplasty and tonsillectomy...
February 2017: Clinical Otolaryngology
Kevin J Friesen, Jamie Falk, Shawn Bugden
BACKGROUND: Meperidine (pethidine) is an opioid analgesic that offers little advantage relative to other opioids and several disadvantages including limited potency, short duration of action, and the production of a neurotoxic metabolite (normeperidine) with a long half-life. Older adults are more sensitive to meperidine's side effects and may have diminished renal function which leads to the accumulation of normeperidine. The Institute for Safe Medication Practices has suggested avoiding meperidine in older adults, limiting its dose (≤600 mg/day) and duration of use (≤48 h)...
May 11, 2016: BMC Geriatrics
Hamid Saryazdi, Alireza Yazdani, Parvin Sajedi, Omid Aghadavoudi
BACKGROUND: There is no agreement about the effect of adding opioids to local anesthetics in peripheral nerve blocks. The aim of this study was to investigate the effect of adding different opioids with equipotent doses of lidocaine in axillary brachial plexus block using ultrasonography and nerve locator guidance. MATERIALS AND METHODS: In a prospective, randomized, double-blind clinical trial study, 72 adult patients aged 18-65 years old scheduled for orthopedic surgery of the forearm and hand with axillary brachial plexus block were selected and randomly allocated to four groups...
2015: Advanced Biomedical Research
Altug Tuncel, Melih Balci, Aysun Postaci, Yilmaz Aslan, Ali Atan
PURPOSE: We compared the effects of local levobupivacaine infiltration, intravenous paracetamol, intravenous lornoxicam treatments on postoperative analgesia in patients submitted to transperitoneal laparoscopic renal and adrenal surgery. MATERIALS AND METHODS: Sixty adult patients 26 and 70 years who underwent laparoscopic renal and adrenal surgery were randomized into three groups with 20 patients each: Group 1 received local 20 mL of levobupivacaine 0.25% infiltration to the trocar incisions before skin closure...
July 2015: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Ahmed I Refaat, Mohammed S Hedaya, Hussein M Ezzat, M Maher H Fayed, A F Salama, Ahmed H Helmy
This study compared the postoperative analgesic effect of local anesthetic (LA) injected subcutaneous (SC) alone versus local anesthetic injected both SC and deep in patients undergoing open appendecectomy operations. Sixty patients ASA class I-II undergoing open appendecectomy for presumed acute appendicitis will be randomly assigned into three groups. After routine monitoring, anesthesia induction was performed with propofol, fentanyl and, cis-atracurium; later, maintenance was continued with isoflurane. GA received local infiltration of the skin prior to incision with bupivacaine 0...
April 2015: Journal of the Egyptian Society of Parasitology
Shu-Hung Chuang, Wen-Jui Yang, Chih-Ming Chang, Chih-Sheng Lin, Meng-Ching Yeh
BACKGROUND: Single-incision laparoscopic cholecystectomy (SILC) has been shown to be safe for uncomplicated gallbladder diseases. Routinely applying SILC is debatable. METHODS: Two hundred SILCs were performed with single-incision multiple-port longitudinal-array and self-camera techniques. RESULTS: Eighty-eight (44%) procedures were scheduled for complicated diseases. The routine group had a higher comorbidity rate, a lower preoperative endoscopic retrograde cholangiopancreatography rate, a higher intraoperative cholangiography rate, a higher proportion of complicated gallbladder diseases, shorter operative time, more intraoperative blood loss, and lower postoperative pethidine dose than the selective group (the first 73 patients)...
August 2015: American Journal of Surgery
A Amatya, M N Marhatta, G S Shrestha, A Shrestha, A Amatya
BACKGROUND: Combination therapy with two or more different drugs, with the intension of reaching the same therapeutic goal, was heavily criticized for a long time. However, it is accepted today, especially when advantage over monotherapy can be proved. Our study was undertaken to compare whether propofol priming and midazolam predosing would affect total induction dose requirement of Propofol. METHODS: A prospective randomized, double blind control study was conducted where 120 patients (16-65 years) were divided into 3 groups...
January 2014: Journal of Nepal Health Research Council
Alexander Schnabel, Sylvia U Reichl, Peter K Zahn, Esther Pogatzki-Zahn
BACKGROUND: Several surveys over the past few years have demonstrated that postoperative pain in children is not treated appropriately. One pharmacological treatment option in a multimodal approach for postoperative pain treatment is the systemic administration of opioids. However, opioids are rarely used for postoperative pain treatment in children due to fear of adverse events. One long-standing opioid for systemic use is nalbuphine, a kappa-receptor agonist and µ-receptor antagonist...
2014: Cochrane Database of Systematic Reviews
Sameer N Desai, M C B Santhosh
BACKGROUND AND OBJECTIVES: A review of all the adjuncts for intravenous regional anaesthesia concluded that there is good evidence to recommend NonSteroidal Anti-Inflammatory agents and pethidine in the dose of 30mg dose as adjuncts to intravenous regional anaesthesia. But there are no studies to compare pethidine of 30mg dose to any of the NonSteroidal Anti-Inflammatory agents. METHODS: In a prospective, randomized, double blind study, 45 patients were given intravenous regional anaesthesia with either lignocaine alone or lignocaine with pethidine 30mg or lignocaine with ketprofen 100mg...
July 2014: Brazilian Journal of Anesthesiology
Seyed Hossein Hosseini Sharifi, Mohammad Hossein Soltani, Gholam Hossein Rezaeetalab, Reyhaneh Yamini Sharif, Flora Khaledi, Alireza Lashay, Farzaneh Sharifiaghdas
BACKGROUND AND PURPOSE: Pain at the surgery site is a common complaint in patients who experience percutaneous nephrolithotomy (PCNL). The aim of this double-blind, randomized clinical trial is evaluation of the effect of scheduled infusion of bupivacaine on postsurgical pain and narcotic consumption after tubeless PCNL under spinal anesthesia. PATIENTS AND METHODS: Forty patients were randomly divided into two groups. A small caliber fenestrated feeding tube was placed into the nephrostomy tract under direct vision in a manner in which its tip lied close to the renal capsule...
November 2014: Journal of Endourology
Chung Hyun Tae, Ki Joo Kang, Byung-Hoon Min, Joong Hyun Ahn, Seonwoo Kim, Jun Haeng Lee, Poong-Lyul Rhee, Jae J Kim
BACKGROUND: The incidence, risk factors and management strategy of paradoxical reaction to midazolam during endoscopy are yet to be clarified. METHODS: This single center prospective study included 4140 adult patients (2263 males, mean age of 57.7 ± 12.6) undergoing endoscopy under sedation with midazolam and pethidine between September 2011 and December 2011. The characteristics of patients with and without paradoxical reaction were compared. For patients who experienced paradoxical reaction and received flumazenil, their endoscopic images were reviewed to assess whether European Society of Gastrointestinal Endoscopy guidelines were met as quality indicator of endoscopy...
August 2014: Digestive and Liver Disease
Byung Uk Lee, Myung-Hwan Kim, Joon Hyuk Choi, Jun-Ho Choi, Hyo Jung Kim, Do Hyun Park, Sang Soo Lee, Dong-Wan Seo, Sung-Koo Lee
BACKGROUND/AIMS: A retrospective analysis was performed to evaluate the safety and effectiveness of extracorporeal shock wave lithotripsy (ESWL) for pancreatolithiasis on successive days under intravenous bolus of pethidine alone. METHODS: Ninety patients with calcified pancreatic stones (≥5 mm) presenting with abdominal pain were selected for ESWL. ESWL was performed with an electroconductive lithotripter under fluoroscopic target systems. Fragmented calculi after ESWL were removed by endotherapy...
April 2014: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
M J Paech, N J McDonnell, A Sinha, C Baber, E A Nathan
The benefit of combining non-opioid analgesics with neuraxial opioids for analgesia after caesarean delivery has not been clearly established. Larger doses of paracetamol or cyclooxygenase-2 inhibitors have not been evaluated. A randomised, double blind, double-dummy, parallel group placebo-controlled clinical trial was conducted among women having elective caesarean delivery under spinal anaesthesia, followed by pethidine patient-controlled epidural analgesia. Patients received placebos (group C); intravenous parecoxib 40 mg then oral celecoxib 400 mg at 12 hours (group PC); intravenous paracetamol 2 g then oral 1 g six-hourly (group PA); or these regimens combined (group PCPA)...
January 2014: Anaesthesia and Intensive Care
J H Foreman, R Ruemmler
REASONS FOR PERFORMING STUDY: There are no peer reviewed, blinded controlled studies regarding the skeletal analgesic efficacy of intramuscularly administered meperidine in horses. OBJECTIVES: Using an adjustable heart bar shoe model of equine foot pain, the objective of this study was to test the hypothesis that meperidine (pethidine) administered intramuscularly would prove more efficacious in alleviating lameness than a saline placebo. STUDY DESIGN: Crossover pharmacodynamic experiment...
December 2013: Equine Veterinary Journal. Supplement
Abdullah Demirhan, Umit Yasar Tekelioglu, Akcan Akkaya, Murat Bilgi, Tayfun Apuhan, Furkan Erol Karabekmez, Hakan Bayir, Adem Deniz Kurt, Hasan Kocoglu
BACKGROUND: We investigated the effect of a combination of pregabalin and dexamethasone, when used as part of a multimodal analgesic regimen, on pain control after rhinoplasty operations. METHODS: Sixty patients were enrolled in this study. They were randomly assigned into three groups: Group C (placebo + placebo), Group P (pregabalin + placebo), and Group PD (pregabalin + dexamethasone). Patients received either pregabalin 300 mg orally 1 h before surgery, dexamethasone 8 mg intravenously during induction, or placebo according to their allocation...
December 2013: Aesthetic Plastic Surgery
Jiang Hao, Ji-shen Luo, Qi Weng, Yi He, Jun Liu, Ming-hao Yang, Ge-yuan Bian, Tao Liu
OBJECTIVE: To compare the efficacy of dextraldexmede (DEX) and propofol on sedation and β-endorphin (β-EP) in patients with moderate and severe traumatic brain injury (TBI). METHODS: Ninety patients with moderate and severe TBI with Glasgow coma score (GCS) 6-13 were randomly divided into three groups according to the order of admission of odd and even numbers. In group A (DEX/+morphine), DEX load 0.5-1.0 μg/kg was injected within 30 minutes, and maintaining at 0...
June 2013: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Ahed Zeidan, Sultan Al-Temyatt, Hany Mowafi, Tharwat Ghattas
Some evidence exist to suggest that women experience more pain and require more medication than men to achieve a similar state of analgesia. However, this was not studied in morbidly obese patients. The study evaluates the effect of gender on postoperative pain and analgesic consumption in the first 24 h in morbidly obese patients who undergo laparoscopic Roux-En-Y gastric bypass surgery (RYNGPB). One hundred thirty obese adult patients who underwent elective RYNGPB were included in the study. Postoperative pain scores were compared using a numeric rating scale, at intervals (0, 15, 30, 45, 60, 90, and 120 min), and following discharge from the postanesthesia care unit (PACU) at 6, 12, and 24 h...
November 2013: Obesity Surgery
Naruemol Prachanpanich, Worapot Apinyachon, Wichai Ittichaikulthol, Orawan Moontripakdi, Amporn Jitaree
BACKGROUND: Dexmedetomidine provides profound levels of sedation without affecting cardiovascular and respiratory stability based on its pharmacological profile. It may be a valuable sedative for procedures with minimal to mild pain. Electrophysiology study (EP study) is a mildly painful procedure that requires conscious sedation. The authors hypothesized that dexmedetomidine would cause lower respiratory and cardiovascular depression than propofol during equal sedation level in an electrophysiology study...
March 2013: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Teresa J Carrette, Jamie J Seymour
INTRODUCTION: We reviewed the occurrence, trends, definition and severity of the Irukandji syndrome for the Cairns region of North Queensland, Australia. METHODS: A retrospective analysis of patient files from two sources was conducted: historic accounts kept by Dr Jack Barnes for the period 1942 to 1967, and records from the Emergency Unit in Cairns Base Hospital for 1995 to 2007. RESULTS: There has been a significant increase in the length of the Irukandji season since it was first reliably recorded (15 days in 1961; 151 days in 2002); however, annual numbers of envenomations were highly variable...
March 2013: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
Farzane Ebrahimifard, Navid Nooraei
Pain is the most common complaint of patients on the first day after laparoscopic cholecystectomy (LC). This clinical trial compared the effects of intraperitoneal (IP) bupivacaine and intravenous (IV) pethidine on this pain. Forty-eight patients who underwent LC were randomly assigned to 2 groups of IP bupivacaine and IV pethidine. Postoperative pain, oral analgesic consumption, peak expiratory flow rate, and presence of nausea or vomiting was recorded at baseline and 4, 8, and 24 hours after surgery. Patients who received IP bupivacaine showed a significantly lower pain score (P = 0...
February 2013: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
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