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https://www.readbyqxmd.com/read/28493648/detection-of-localized-hepatocellular-amino-acid-kinetics-by-using-mass-spectrometry-imaging-of-stable-isotopes
#1
Martijn Arts, Zita Soons, Shane R Ellis, Keely A Pierzchalski, Benjamin Balluff, Gert B Eijkel, Ludwig J Dubois, Natasja G Lieuwes, Stijn M Agten, Tilman M Hackeng, Luc J C van Loon, Ron M A Heeren, Steven W M Olde Damink
Mass spectrometry imaging (MSI) simultaneously detects and identifies the spatial distribution of numerous molecules throughout tissues. Currently, MSI is limited to providing a static and ex vivo snapshot of highly dynamic systems in which molecules are constantly synthesized and consumed. Herein, we demonstrate an innovative MSI methodology to study dynamic molecular changes of amino acids within biological tissues by measuring the dilution and conversion of stable isotopes in a mouse model. We evaluate the method specifically on hepatocellular metabolism of the essential amino acid l-phenylalanine, associated with liver diseases...
May 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28493149/fitting-growth-curve-models-in-the-bayesian-framework
#2
Zita Oravecz, Chelsea Muth
Growth curve modeling is a popular methodological tool due to its flexibility in simultaneously analyzing both within-person effects (e.g., assessing change over time for one person) and between-person effects (e.g., comparing differences in the change trajectories across people). This paper is a practical exposure to fitting growth curve models in the hierarchical Bayesian framework. First the mathematical formulation of growth curve models is provided. Then we give step-by-step guidelines on how to fit these models in the hierarchical Bayesian framework with corresponding computer scripts (JAGS and R)...
May 10, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28485441/fibre-fortification-of-wheat-bread-impact-on-mineral-composition-and-bioaccessibility
#3
Zita E Martins, Edgar Pinto, Agostinho A Almeida, Olívia Pinho, Isabel M P L V O Ferreira
In this work, wheat bread was fortified with fibre enriched extracts recovered from agroindustry by-products, namely, elderberry skin, pulp and seeds (EE); orange peel (OE); pomegranate peel and interior membranes (PE); and spent yeast (YE). The impact of this fortification on the total and bioaccessible mineral composition of wheat breads, estimated mineral daily intake, and the relationship between bioaccessibility and dietary fibre was evaluated. Fortification with OE, EE, and PE improved the content of essential minerals in bread when compared to control bread...
May 9, 2017: Food & Function
https://www.readbyqxmd.com/read/28484838/projecting-the-impact-of-climate-change-on-phenology-of-winter-wheat-in-northern-lithuania
#4
Romualdas Juknys, Rimantas Velička, Arvydas Kanapickas, Zita Kriaučiūnienė, Laura Masilionytė, Ilona Vagusevičienė, Rita Pupalienė, Martynas Klepeckas, Gintarė Sujetovienė
Climate warming and a shift in the timing of phenological phases, which lead to changes in the duration of the vegetation period may have an essential impact on the productivity of winter crops. The main purpose of this study is to examine climate change-related long-term (1961-2015) changes in the duration of both initial (pre-winter) and main (post-winter) winter wheat vegetation seasons and to present the projection of future phenological changes until the end of this century. Delay and shortening of pre-winter vegetation period, as well as the advancement and slight extension of the post-winter vegetation period, resulted in the reduction of whole winter wheat vegetation period by more than 1 week over the investigated 55 years...
May 8, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28472076/plasminogen-activator-activity-in-tears-of-pregnant-women
#5
Adrienne Csutak, Zita Steiber, József Tőzsér, Attila Jakab, András Berta, David M Silver
PURPOSE: Plasminogen activator activity (PAA) in tears of pregnant women was investigated at various gestation times to assess the availability of plasminogen activator for aiding potential corneal wound healing processes during pregnancy. METHODS: PAA was measured by a spectrophotometric method. The analysis used 91 tear samples from pregnant and non-pregnant women, supplemented with 10 additional tear PAA measurements from non-pregnant women obtained in a previous study...
2017: PloS One
https://www.readbyqxmd.com/read/28442988/adiponectin-receptors-are-less-sensitive-to-stress-in-a-transgenic-mouse-model-of-alzheimer-s-disease
#6
Zoltán P Várhelyi, János Kálmán, Zita Oláh, Eszter V Ivitz, Eszter K Fodor, Miklós Sántha, Zsolt L Datki, Magdolna Pákáski
Background: Adiponectin and leptin are implicated in the initiation and pathomechanism of Alzheimer's disease (AD). The serum concentrations of these adipokines has been extensively studied in AD, however little is known about their receptors in this disease. Objective: We developed a novel approach to examine whether the receptors of adiponectin (AdipoR1 and -R2) and/or leptin (LepR) can contribute to AD pathomechanism. To achieve this, we investigated the effect of both genetic and environmental factors associated with AD on the expression of these receptors...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28441450/commensal-bacteria-and-essential-amino-acids-control-food-choice-behavior-and-reproduction
#7
Ricardo Leitão-Gonçalves, Zita Carvalho-Santos, Ana Patrícia Francisco, Gabriela Tondolo Fioreze, Margarida Anjos, Célia Baltazar, Ana Paula Elias, Pavel M Itskov, Matthew D W Piper, Carlos Ribeiro
Choosing the right nutrients to consume is essential to health and wellbeing across species. However, the factors that influence these decisions are poorly understood. This is particularly true for dietary proteins, which are important determinants of lifespan and reproduction. We show that in Drosophila melanogaster, essential amino acids (eAAs) and the concerted action of the commensal bacteria Acetobacter pomorum and Lactobacilli are critical modulators of food choice. Using a chemically defined diet, we show that the absence of any single eAA from the diet is sufficient to elicit specific appetites for amino acid (AA)-rich food...
April 2017: PLoS Biology
https://www.readbyqxmd.com/read/28438873/angiotensin-converting-enzyme-inhibition-improves-the-effectiveness-of-transcutaneous-carbon-dioxide-treatment
#8
Balazs Nemeth, Istvan Kiss, Timea Jencsik, Ivan Peter, Zita Kreska, Tamas Koszegi, Attila Miseta, Peter Kustan, Imre Boncz, Andrea Laczo, Zeno Ajtay
AIM: To study the effect of carbon dioxide (CO2) therapy on the nitric oxide (NO) pathway by monitoring plasma asymmetric dimethylarginine (ADMA) concentrations. PATIENTS AND METHODS: Forty-seven hypertensive patients who underwent transcutaneous CO2 therapy were enrolled. Thirty healthy individuals were recruited for the control group. Blood samples were taken one hour before, as well as one hour, 24 hours and 3 weeks after the first CO2 treatment. Controls did not undergo CO2 treatment...
May 2017: In Vivo
https://www.readbyqxmd.com/read/28432650/efficacy-and-tolerability-of-a-2-year-rituximab-maintenance-therapy-in-patients-with-advanced-follicular-lymphoma-after-induction-of-response-with-rituximab-containing-first-line-regimens-husom-study
#9
Tamás Schneider, András Rosta, Hajna Losonczy, Gáspár Radványi, György Ujj, Miklós Egyed, Árpád Illés, János Jakucs, László Szerafin, Zoltán Gasztonyi, Tamás Masszi, János Iványi, Judit Demeter, Péter Dombi, Antal Tóth, Zita Borbényi
Follicular lymphoma is a lymphoid malignancy commonly showing slow progression which makes the treatment of the disease challenging. Rituximab monotherapy and rituximab added to standard chemotherapy has been proven to increase survival among patients with advanced stage of the disease. However, the benefit of a rituximab maintenance therapy after induction was still unclear at the time of the initiation of this study. HUSOM was a phase III open-label, single-arm, multi-centre study aimed to assess the efficacy and the safety of the 12 cycles of rituximab (375 mg/m(2) every 8 weeks) maintenance therapy in patients had already presented partial or complete response to R-CVP or R-CHOP...
April 21, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28409497/identification-of-myoelectric-signals-of-pregnant-rat-uterus-new-method-to-detect-myometrial-contraction
#10
Kálmán F Szűcs, György Grosz, Miklós Süle, Anikó Nagy, Zita Tiszai, Reza Samavati, Róbert Gáspár
AIM: To develop an electromyography method for pregnant rat uterus in vivo and to separate myometrial signals from the gastrointestinal tract signals. METHODS: Pregnant Sprague-Dawley rats (n=8) were anaesthetized and their stomach, small intestine, and large intestine were removed from the abdomen. A pair of thread electrodes was inserted into the uterus, while a pair of disk electrodes was placed subcutaneously above the myometrium. Additionally, a strain gauge sensor was fixed on the surface of the myometrium and cecum for the parallel detection of mechanical contractions in rats (n=18) with intact gastrointestinal tract...
April 14, 2017: Croatian Medical Journal
https://www.readbyqxmd.com/read/28405292/effects-of-genetically-modified-maize-events-expressing-cry34ab1-cry35ab1-cry1f-and-cp4-epsps-proteins-on-arthropod-complex-food-webs
#11
Zoltán Pálinkás, József Kiss, Mihály Zalai, Ágnes Szénási, Zita Dorner, Samuel North, Guy Woodward, Adalbert Balog
Four genetically modified (GM) maize (Zea mays L.) hybrids (coleopteran resistant, coleopteran and lepidopteran resistant, lepidopteran resistant and herbicide tolerant, coleopteran and herbicide tolerant) and its non-GM control maize stands were tested to compare the functional diversity of arthropods and to determine whether genetic modifications alter the structure of arthropods food webs. A total number of 399,239 arthropod individuals were used for analyses. The trophic groups' number and the links between them indicated that neither the higher magnitude of Bt toxins (included resistance against insect, and against both insects and glyphosate) nor the extra glyphosate treatment changed the structure of food webs...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28396505/genetic-characterisation-of-dog-personality-traits
#12
Joanna Ilska, Marie J Haskell, Sarah C Blott, Enrique Sánchez-Molano, Zita Polgar, Sarah E Lofgren, Dylan N Clements, Pam Wiener
The genetic architecture of behavioural traits in dogs is of great interest to owners, breeders and professionals involved in animal welfare, as well as to scientists studying the genetics of animal (including human) behaviour. The genetic component of dog behaviour is supported by between-breed differences and some evidence of within-breed variation. However, it is a challenge to gather sufficiently large datasets to dissect the genetic basis of complex traits such as behaviour, which are both time-consuming and logistically difficult to measure, and known to be influenced by non-genetic factors...
April 10, 2017: Genetics
https://www.readbyqxmd.com/read/28394887/transmission-of-zika-virus-through-breast-milk-and-other-breastfeeding-related-bodily-fluids-a-systematic-review
#13
Susannah Colt, Maria N Garcia-Casal, Juan Pablo Peña-Rosas, Julia L Finkelstein, Pura Rayco-Solon, Zita C Weise Prinzo, Saurabh Mehta
BACKGROUND: Zika virus (ZIKV) infection is an emerging mosquito-borne disease, which is associated with an increase in central nervous system malformations and newborn microcephaly cases. This review investigated evidence of breastfeeding transmission from ZIKV-infected mothers to their children and the presence of ZIKV infection in breastfeeding-related fluids. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a systematic review of observational studies, case studies, and surveillance reports involving breastfeeding women with ZIKV infection in several international databases...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28393475/unprofessional-content-on-facebook-accounts-of-us-urology-residency-graduates
#14
Kevin Koo, Zita Ficko, E Ann Gormley
OBJECTIVE: To characterize unprofessional content on public Facebook accounts of contemporary US urology residency graduates. METHODS: Facebook was queried with the names of all urologists who graduated from US urology residency programmes in 2015 to identify publicly accessible profiles. Profiles were assessed for unprofessional or potentially objectionable content using a prospectively designed rubric, based on professionalism guidelines by the American Urological Association, the American Medical Association, and the Accreditation Council for Graduate Medical Education...
April 9, 2017: BJU International
https://www.readbyqxmd.com/read/28368488/plasma-microrna-levels-are-associated-with-hbeag-status-and-treatment-response-in-chronic-hepatitis-b-patients
#15
Meike H van der Ree, Louis Jansen, Zita Kruize, Ad C van Nuenen, Karel A van Dort, R Bart Takkenberg, Hendrik W Reesink, Neeltje A Kootstra
Background: Hepatitis B virus (HBV) modulates miRNA expression to support viral replication. The aim of this study was to identify miRNAs associated with HBeAg-status and response to antiviral therapy in chronic hepatitis B (CHB) patients, and to assess if these miRNAs are secreted by hepatoma cells. Methods: Plasma miRNA levels were measured by RT-qPCR in healthy controls (n=10), and pre-treatment samples of an identification cohort (n=24) and a confirmation cohort (n=64) of CHB patients treated with peg-interferon/nucleotide analogue combination therapy...
March 23, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28366679/o2-%C3%A2-and-h2o2-mediated-disruption-of-fe-metabolism-causes-the-differential-susceptibility-of-nsclc-and-gbm-cancer-cells-to-pharmacological-ascorbate
#16
Joshua D Schoenfeld, Zita A Sibenaller, Kranti A Mapuskar, Brett A Wagner, Kimberly L Cramer-Morales, Muhammad Furqan, Sonia Sandhu, Thomas L Carlisle, Mark C Smith, Taher Abu Hejleh, Daniel J Berg, Jun Zhang, John Keech, Kalpaj R Parekh, Sudershan Bhatia, Varun Monga, Kellie L Bodeker, Logan Ahmann, Sandy Vollstedt, Heather Brown, Erin P Shanahan Kauffman, Mary E Schall, Ray J Hohl, Gerald H Clamon, Jeremy D Greenlee, Matthew A Howard, Michael K Shultz, Brian J Smith, Dennis P Riley, Frederick E Domann, Joseph J Cullen, Garry R Buettner, John M Buatti, Douglas R Spitz, Bryan G Allen
Pharmacological ascorbate has been proposed as a potential anti-cancer agent when combined with radiation and chemotherapy. The anti-cancer effects of ascorbate are hypothesized to involve the autoxidation of ascorbate leading to increased steady-state levels of H2O2; however, the mechanism(s) for cancer cell-selective toxicity remain unknown. The current study shows that alterations in cancer cell mitochondrial oxidative metabolism resulting in increased levels of O2(⋅-) and H2O2 are capable of disrupting intracellular iron metabolism, thereby selectively sensitizing non-small-cell lung cancer (NSCLC) and glioblastoma (GBM) cells to ascorbate through pro-oxidant chemistry involving redox-active labile iron and H2O2...
April 10, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28363637/dsm265-for-plasmodium-falciparum-chemoprophylaxis-a-randomised-double-blinded-phase-1-trial-with-controlled-human-malaria-infection
#17
Mihály Sulyok, Thomas Rückle, Alexandra Roth, Raymund E Mürbeth, Stephan Chalon, Nicola Kerr, Sonia Schnieper Samec, Nathalie Gobeau, Carlos Lamsfus Calle, Javier Ibáñez, Zita Sulyok, Jana Held, Tamirat Gebru, Patricia Granados, Sina Brückner, Christian Nguetse, Juliana Mengue, Albert Lalremruata, Kim Lee Sim, Stephen L Hoffman, Jörg J Möhrle, Peter G Kremsner, Benjamin Mordmüller
BACKGROUND: A drug for causal (ie, pre-erythrocytic) prophylaxis of Plasmodium falciparum malaria with prolonged activity would substantially advance malaria control. DSM265 is an experimental antimalarial that selectively inhibits the parasite dihydroorotate dehydrogenase. DSM265 shows in vitro activity against liver and blood stages of P falciparum. We assessed the prophylactic activity of DSM265 against controlled human malaria infection (CHMI). METHODS: At the Institute of Tropical Medicine, Eberhard Karls University (Tübingen, Germany), healthy, malaria-naive adults were allocated to receive 400 mg DSM265 or placebo either 1 day (cohort 1A) or 7 days (cohort 2) before CHMI by direct venous inoculation (DVI) of 3200 aseptic, purified, cryopreserved P falciparum sporozoites (PfSPZ Challenge; Sanaria Inc, Rockville, MD, USA)...
March 28, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28350068/concurrence-of-chromosome%C3%A2-3%C3%A2-and%C3%A2-4-aberrations-in-human-uveal-melanoma
#18
Eva Sipos, Kata Hegyi, Andrea Treszl, Zita Steiber, Gabor Mehes, Nikoletta Dobos, Klara Fodor, Gabor Olah, Lorant Szekvolgyi, Andrew V Schally, Gabor Halmos
Uveal melanoma (UM) is the most common primary intraocular malignancy with a very poor prognosis. The most frequent chromosome aberration in UM is the monosomy of chromosome 3. Previously, we demonstrated that ~50% of UMs express type-I receptor for luteinizing hormone‑releasing hormone (LH-RH-R). The gene encoding LH-RH-R is located in chromosome 4 (location: 4q21.2); however, the occurrence of numerical aberrations of chromosome 4 have never been studied in UM. In the present study, we investigated the abnormalities of chromosome 3 and 4, and the possible correlation between them, as well as with LH-RH-R expression...
April 2017: Oncology Reports
https://www.readbyqxmd.com/read/28329860/modeling-intraindividual-dynamics-using-stochastic-differential-equations-age-differences-in-affect-regulation
#19
Julie Wood, Zita Oravecz, Nina Vogel, Lizbeth Benson, Sy-Miin Chow, Pamela Cole, David E Conroy, Aaron L Pincus, Nilam Ram
Objectives: Life-span theories of aging suggest improvements and decrements in individuals' ability to regulate affect. Dynamic process models, with intensive longitudinal data, provide new opportunities to articulate specific theories about individual differences in intraindividual dynamics. This paper illustrates a method for operationalizing affect dynamics using a multilevel stochastic differential equation (SDE) model, and examines how those dynamics differ with age and trait-level tendencies to deploy emotion regulation strategies (reappraisal and suppression)...
March 2, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28280722/tissue-engineered-solutions-in-plastic-and-reconstructive-surgery-principles-and-practice
#20
REVIEW
Sarah Al-Himdani, Zita M Jessop, Ayesha Al-Sabah, Emman Combellack, Amel Ibrahim, Shareen H Doak, Andrew M Hart, Charles W Archer, Catherine A Thornton, Iain S Whitaker
Recent advances in microsurgery, imaging, and transplantation have led to significant refinements in autologous reconstructive options; however, the morbidity of donor sites remains. This would be eliminated by successful clinical translation of tissue-engineered solutions into surgical practice. Plastic surgeons are uniquely placed to be intrinsically involved in the research and development of laboratory engineered tissues and their subsequent use. In this article, we present an overview of the field of tissue engineering, with the practicing plastic surgeon in mind...
2017: Frontiers in Surgery
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