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https://www.readbyqxmd.com/read/28097068/hepatic-fibrosis-and-factors-associated-with-liver-stiffness-in-hiv-mono-infected-individuals
#1
Mihály Sulyok, Tamás Ferenci, Mihály Makara, Gábor Horváth, János Szlávik, Zsófia Rupnik, Luca Kormos, Zsuzsanna Gerlei, Zita Sulyok, István Vályi-Nagy
BACKGROUND: Liver disease has become an important cause of morbidity and mortality even in those HIV-infected individuals who are devoid of hepatitis virus co-infection. The aim of this study was to evaluate the degree of hepatic fibrosis and the role of associated factors using liver stiffness measurement in HIV mono-infected patients without significant alcohol intake. METHODS: We performed a cross-sectional study of 101 HIV mono-infected patients recruited prospectively from March 1, 2014 to October 30, 2014 at the Center for HIV, St István and St László Hospital, Budapest, Hungary...
2017: PeerJ
https://www.readbyqxmd.com/read/28092737/complex-molecular-changes-induced-by-chronic-progestogens-exposure-in-roach-rutilus-rutilus
#2
Gabor Maasz, Zita Zrinyi, Peter Takacs, Sandor Lovas, Istvan Fodor, Tibor Kiss, Zsolt Pirger
In our previous study, we measured 0.23-13.67ng/L progestogens (progesterone, drospirenone, levonorgestrel) in natural waters in the catchment area of the largest shallow lake of Central Europe, Lake Balaton. Progestogen contaminations act as potent steroids with mixed progestagenic, androgenic and mild estrogenic effects that is why our aim was to investigate the morphological and molecular effects of mixture of progesterone, drospirenone, and levonorgestrel in environmentally relevant (10ng/L) and higher (50 and 500ng/L) exposure concentrations in common roach, Rutilus rutilus...
January 13, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28054527/temperature-increase-induced-by-modulated-electrohyperthermia-oncothermia%C3%A2-in-the-anesthetized-pig-liver
#3
Lajos Balogh, András Polyák, Zita Pöstényi, Veronika Kovács-Haász, Miklós Gyöngy, Julianna Thuróczy
AIM OF STUDY: Is to show the intrahepatic temperature development in anesthetized pig. MATERIALS AND METHODS: Temperature development in the liver of anesthetized pig is measured to study the thermal effects of capacitive coupled energy transfer. The treatment was made by modulated electrohyperthermia (mEHT, trade name: oncothermia ®), controlled by a fluoroptical temperature sensing positioned by the ultrasound-guided process. Various fits of coupling were studied...
July 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28025980/cracking-the-mnemonic-code
#4
Eva Zita Patai, Hugo J Spiers
No abstract text is available yet for this article.
December 27, 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/27999799/alveolar-ridge-reconstruction-with-titanium-meshes-and-simultaneous-implant-placement-a-retrospective-multicenter-clinical-study
#5
Raquel Zita Gomes, Andres Paraud Freixas, Chang-Hun Han, Sohueil Bechara, Isaac Tawil
Objective. To evaluate horizontal bone gain and implant survival and complication rates in patients treated with titanium meshes placed simultaneously with dental implants and fixed over them. Methods. Twenty-five patients treated with 40 implants and simultaneous guided bone regeneration with titanium meshes (i-Gen®, MegaGen, Gyeongbuk, Republic of Korea) were selected for inclusion in the present retrospective multicenter study. Primary outcomes were horizontal bone gain and implant survival; secondary outcomes were biological and prosthetic complications...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27974681/loss-of-expression-of-the-recycling-receptor-fcrn-promotes-tumor-cell-growth-by-increasing-albumin-consumption
#6
Rafal Swiercz, Min Mo, Priyanka Khare, Zita Schneider, Raimund J Ober, E Sally Ward
Tumor cells rely on high concentrations of amino acids to support their growth and proliferation. Although increased macropinocytic uptake and lysosomal degradation of the most abundant serum protein, albumin, in Ras-transformed cells can meet these demands, it is not understood how the majority of tumor cells that express wild type Ras achieve this. In the current study we reveal that the neonatal Fc receptor, FcRn, regulates tumor cell proliferation through the ability to recycle its ligand, albumin. By contrast with normal epithelial cells, we show that human FcRn is present at very low or undetectable levels in the majority of tumor cell lines analyzed...
December 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/27958372/global-map-of-oxytocin-vasopressin-like-neuropeptide-signalling-in-insects
#7
Zita Liutkeviciute, Johannes Koehbach, Thomas Eder, Esther Gil-Mansilla, Christian W Gruber
Oxytocin and vasopressin mediate a range of physiological functions that are important for osmoregulation, reproduction, social behaviour, memory and learning. The origin of this signalling system is thought to date back ~600 million years. Oxytocin/vasopressin-like peptides have been identified in several invertebrate species and they appear to be functionally related across the entire animal kingdom. There is little information available about the biology of this peptide G protein-coupled receptor signalling system in insects...
December 13, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27934943/stable-c-n-isotopes-in-2100-year-b-p-human-bone-collagen-indicate-rare-dietary-dominance-of-c4-plants-in-ne-italy
#8
Zita Laffranchi, Antonio Delgado Huertas, Sylvia A Jiménez Brobeil, Arsenio Granados Torres, Jose A Riquelme Cantal
C4 plants (e.g. maize, millet), part of our current diet, are only endemic of reduced areas in South-Europe due to their need of warm climates. Since the first vestiges of agriculture in Europe remains of C4 plants were recorded but their overall proportion in the human diet remains unknown. Therefore, isotopic (δ(13)C and δ(15)N) composition of bone collagen from the skeletal remains (human and animals) of a Celtic population, Cenomani Gauls, from Verona (3(rd) to 1(st) century BC) in the NE Italy provide a new perspective on this matter...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27917673/-first-attempts-in-the-introduction-of-cryopreservation-of-ovarian-tissues
#9
Péter Fancsovits, János Urbancsek, László Fónyad, Anna Sebestyén, Gézáné Csorba, Ádám Lehner, Zita Kaszás, János Rigó, Attila Bokor
INTRODUCTION: The oncological treatment may damage ovarian function. To prevent this, it is possible to cryopreserve the ovarian tissue, and to keep the samples for long-term storage. The frozen-thawed tissue could be retransplanted after chemo- or radiotherapy. AIM: The aim of our study was to examine the effect of cryopreservation on the viability of ovarian tissue. METHOD: We analyzed the survival of frozen-thawed donated ovarian tissues...
December 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27897677/cognitive-training-in-the-elderly-bottlenecks-and-new-avenues
#10
Nahid Zokaei, Christopher MacKellar, Giedrė Čepukaitytė, Eva Zita Patai, Anna Christina Nobre
Development of measures to preserve cognitive function or even reverse cognitive decline in the ever-growing elderly population is the focus of many research and commercial efforts. One such measure gaining in popularity is the development of computer-based interventions that "exercise" cognitive functions. Computer-based cognitive training has the potential to be specific and flexible, accommodates feedback, and is highly accessible. As in most budding fields, there are still considerable inconsistencies across methodologies and results, as well as a lack of consensus on a comprehensive assessment protocol...
November 29, 2016: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/27871013/tri-and-tetravalent-mannoclusters-cross-link-and-aggregate-bc2l-a-lectin-from-burkholderia-cenocepacia
#11
Magdolna Csávás, Lenka Malinovská, Florent Perret, Milán Gyurkó, Zita Tünde Illyés, Michaela Wimmerová, Anikó Borbás
The opportunistic Gram-negative bacterium Burkholderia cenocepacia causes lethal infections in cystic fibrosis patients. Multivalent mannoside derivatives were prepared as potential inhibitors of lectin BC2L-A, one of the virulence factors deployed by B. cenocepacia in the infection process. An (α1→2)-thio-linked mannobioside mimic bearing an azide functionalized aglycon was conjugated to different multivalent scaffolds such as propargylated calix[4]arenes, methyl gallate and pentaerythritol by azide-alkyne 1,3-dipolar cycloaddition...
January 2, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/27860149/management-and-outcomes-of-patients-with-renal-medullary-carcinoma-a-multicentre-collaborative-study
#12
Amishi Y Shah, Jose A Karam, Gabriel G Malouf, Priya Rao, Zita D Lim, Eric Jonasch, Lianchun Xiao, Jianjun Gao, Ulka N Vaishampayan, Daniel Y Heng, Elizabeth R Plimack, Elizabeth A Guancial, Chunkit Fung, Stefanie R Lowas, Pheroze Tamboli, Kanishka Sircar, Surena F Matin, W Kimryn Rathmell, Christopher G Wood, Nizar M Tannir
OBJECTIVE: To describe the management strategies and outcomes of patients with renal medullary carcinoma (RMC) and characterise predictors of overall survival (OS). PATIENTS AND METHODS: RMC is a rare and aggressive malignancy that afflicts young patients with sickle cell trait; there are limited data on management to date. This is a study of patients with RMC who were treated in 2000-2015 at eight academic institutions in North America and France. The Kaplan-Meier method was used to estimate OS, measured from initial RMC diagnosis to date of death...
November 8, 2016: BJU International
https://www.readbyqxmd.com/read/27852968/-treatment-of-metacognitive-impairments-in-schizophrenia-the-metacognitive-training
#13
Zita Fekete, Edit Vass, Alexander Kancsev, Ildikó Kuritárné Szabó
In the recent years plenty of therapeutic treatment methods have been developed, aimed at neurocognitive impairments in schizophrenia. These trainingprograms can hold up promising results in the improvement of neurocognitive functions. Nevertheless the generalisation on the daily life is not perspicuous. A reason for it might be the supposition, that further factors such as metacognition and social cognition may play a mediator role between neurocognition and functional outcomes. As a result, many socialcognitive remediation methods and programs have emerged targeting the impairment of deficits both in the field of neuro- and social cognition and deficits of metacognition...
2016: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
https://www.readbyqxmd.com/read/27796129/-diagnosis-and-treatment-of-polycythaemia-vera-state-of-the-art
#14
Imelda Marton, Zsófia Simon, Zita Borbényi
Polycythaemia vera (PV), a condition characterized by blood hyperviscosity due to the expansion of the erythrocyte mass is the most common entity among all Philadelphia chromosome-negative myeloproliferative neoplasms. Arterial and venous thrombotic events are leading determinants of morbidity and mortality but impairment of quality of life due to vasomotor symptoms (erythromelalgia, pruritus) and disease-associated symptoms (tiredness, fatigue, pruritus, night sweats, vision problems, headache, concentration loss, abdominal discomfort, early satiety, fever, weight loss) are also present...
October 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27778227/high-tech-or-high-risk-an-analysis-of-media-reports-about-robotic-surgery
#15
Zita Ficko, Kevin Koo, Elias S Hyams
Robotic surgery continues to increase in popularity and prevalence. The adoption of robotic technology has generated controversy and frequent media coverage. We evaluate recent reports of surgical robotics in the lay press to characterize its objectivity. LexisNexis and Factiva consumer news databases were queried for articles pertaining to robotic surgery published during 2010-2015 in the three highest circulation national (US) newspapers as well as New England regional newspapers. Two independent reviewers performed content analysis and assessed headline bias with strong reliability (mean κ = 0...
October 24, 2016: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/27739476/a-renal-olfactory-receptor-aids-in-kidney-glucose-handling
#16
Blythe D Shepard, Lydie Cheval, Zita Peterlin, Stuart Firestein, Hermann Koepsell, Alain Doucet, Jennifer L Pluznick
Olfactory receptors (ORs) are G protein-coupled receptors which serve important sensory functions beyond their role as odorant detectors in the olfactory epithelium. Here we describe a novel role for one of these ORs, Olfr1393, as a regulator of renal glucose handling. Olfr1393 is specifically expressed in the kidney proximal tubule, which is the site of renal glucose reabsorption. Olfr1393 knockout mice exhibit urinary glucose wasting and improved glucose tolerance, despite euglycemia and normal insulin levels...
October 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27730340/cytomegalovirus-infection-in-patients-with-haematological-diseases-and-after-autologous-stem-cell-transplantation-as-consolidation-a-single-centre-study
#17
Klára Piukovics, Gabriella Terhes, Tímea Gurbity-Pálfi, Ágnes Bereczki, Ferenc Rárosi, Judit Deák, Zita Borbényi, Edit Urbán
Because of the widespread use of immunosuppressive drugs, CMV infection is one of the most important causes of morbidity and mortality in patients with haematological malignancies worldwide. The aim of the study was to retrospectively analyse the epidemiology of CMV infection in haematological patients. Between 2008 and 2014, 1238 quantitative CMV DNA detections from plasma specimens were performed. These specimens were collected from 271 patients with haematological malignancy. Patients were grouped on the basis of underlying diseases (lymphoid and myeloid malignancies and other haematological diseases)...
January 2017: Annals of Hematology
https://www.readbyqxmd.com/read/27722387/calcium-l-tartrate-complex-formation-in-neutral-and-in-hyperalkaline-aqueous-solutions
#18
Attila Gácsi, Bence Kutus, Zita Csendes, Tünde Faragó, Gábor Peintler, István Pálinkó, Pál Sipos
The complex formation reaction between the l-tartrate (Tar(2-)) and calcium ions taking place in neutral and in hyperalkaline (pH > 13) aqueous solutions has been investigated. It was demonstrated that upon NaOH addition the solubility of the CaTar(s) precipitate significantly increases. Conductometric and freezing point depression measurements further confirmed that in this process water soluble species are formed as a result of a reaction between the CaTar(s) and the hydroxide ion (or, conversely, between Ca(OH)2(s) and the Tar(2-) ion)...
October 7, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27683524/non-invasive-assessment-of-viability-in-human-embryos-fertilized-in-vitro
#19
Gábor L Kovács, Gergely Montskó, Zita Zrínyi, Nelli Farkas, Ákos Várnagy, József Bódis
Human reproduction is a relatively inefficient process and therefore the number of infertile couples is high. Assisted reproductive technologies (ART) have facilitated the birth of over five million children worldwide. ART, however, superimposes its own relative inefficiency on the preexisting inefficiency of normal reproduction. The efficiency (expressed as pregnancy rate) is generally not more than 30%. Modern reproductive medicine is gradually moving from multiple embryo transfer to the transfer of a single embryo, mainly because of obvious and unwanted side effects of multiple embryo transfer (e...
April 2016: EJIFCC
https://www.readbyqxmd.com/read/27681337/a-not-so-sweet-diagnosis%C3%A2-%C3%A2-leukocytoclastic-vasculitis-masquerading-as-squamous-cell-carcinoma
#20
Mussa Mensa, Zita M Jessop, Nick Wilson-Jones, Iain S Whitaker
Leukocytoclastic vasculitis (LCV) is a rare small-vessel vasculitis characterised by neutrophilic inflammation of post-capillary venules. Incidence varies from 3 to 4.5 per 100 000 people per year. Patients typically present with painful, itchy purpura and erythema, although clinical manifestations can vary making diagnosis a challenge. We report the case of a 75-year-old man with a history of a previously completely excised and grafted squamous cell carcinoma (SCC) on the dorsum of his hand, who presented with an acutely swollen, erythematous and ulcerated lesion adjacent to the graft site...
September 29, 2016: International Wound Journal
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