Read by QxMD icon Read


Blythe D Shepard, Lydie Cheval, Zita Peterlin, Stuart Firestein, Hermann Koepsell, Alain Doucet, Jennifer L Pluznick
Olfactory receptors (ORs) are G protein-coupled receptors which serve important sensory functions beyond their role as odorant detectors in the olfactory epithelium. Here we describe a novel role for one of these ORs, Olfr1393, as a regulator of renal glucose handling. Olfr1393 is specifically expressed in the kidney proximal tubule, which is the site of renal glucose reabsorption. Olfr1393 knockout mice exhibit urinary glucose wasting and improved glucose tolerance, despite euglycemia and normal insulin levels...
October 14, 2016: Scientific Reports
Klára Piukovics, Gabriella Terhes, Tímea Gurbity-Pálfi, Ágnes Bereczki, Ferenc Rárosi, Judit Deák, Zita Borbényi, Edit Urbán
Because of the widespread use of immunosuppressive drugs, CMV infection is one of the most important causes of morbidity and mortality in patients with haematological malignancies worldwide. The aim of the study was to retrospectively analyse the epidemiology of CMV infection in haematological patients. Between 2008 and 2014, 1238 quantitative CMV DNA detections from plasma specimens were performed. These specimens were collected from 271 patients with haematological malignancy. Patients were grouped on the basis of underlying diseases (lymphoid and myeloid malignancies and other haematological diseases)...
October 11, 2016: Annals of Hematology
Attila Gácsi, Bence Kutus, Zita Csendes, Tünde Faragó, Gábor Peintler, István Pálinkó, Pál Sipos
The complex formation reaction between the l-tartrate (Tar(2-)) and calcium ions taking place in neutral and in hyperalkaline (pH > 13) aqueous solutions has been investigated. It was demonstrated that upon NaOH addition the solubility of the CaTar(s) precipitate significantly increases. Conductometric and freezing point depression measurements further confirmed that in this process water soluble species are formed as a result of a reaction between the CaTar(s) and the hydroxide ion (or, conversely, between Ca(OH)2(s) and the Tar(2-) ion)...
October 7, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Gábor L Kovács, Gergely Montskó, Zita Zrínyi, Nelli Farkas, Ákos Várnagy, József Bódis
Human reproduction is a relatively inefficient process and therefore the number of infertile couples is high. Assisted reproductive technologies (ART) have facilitated the birth of over five million children worldwide. ART, however, superimposes its own relative inefficiency on the preexisting inefficiency of normal reproduction. The efficiency (expressed as pregnancy rate) is generally not more than 30%. Modern reproductive medicine is gradually moving from multiple embryo transfer to the transfer of a single embryo, mainly because of obvious and unwanted side effects of multiple embryo transfer (e...
April 2016: EJIFCC
Mussa Mensa, Zita M Jessop, Nick Wilson-Jones, Iain S Whitaker
Leukocytoclastic vasculitis (LCV) is a rare small-vessel vasculitis characterised by neutrophilic inflammation of post-capillary venules. Incidence varies from 3 to 4.5 per 100 000 people per year. Patients typically present with painful, itchy purpura and erythema, although clinical manifestations can vary making diagnosis a challenge. We report the case of a 75-year-old man with a history of a previously completely excised and grafted squamous cell carcinoma (SCC) on the dorsum of his hand, who presented with an acutely swollen, erythematous and ulcerated lesion adjacent to the graft site...
September 29, 2016: International Wound Journal
Zsófia Simon, Imelda Marton, Zita Borbényi, Árpád Illés
Primary myelofibrosis is one of the Philadelphia negative chronic myeloproliferative neoplasms. It is a rare disease featured by cytopenias and hepatosplenomegaly. Although the etiology of the disease is still unknown, our knowledge about its pathology and prognosis has been improving in the last few years. Furthermore, the JAK2 inhibitor ruxolitinib has become available in Hungary since 2015. Beside its high efficacy in spleen volume and in reduction of myelofibrosis-associated symptoms, this novel therapy also exerts a disease-modifying effect and, therefore, ruxolitinib may improve the life expectancy too...
September 2016: Orvosi Hetilap
David Pierce, Fiona Little, James Bennett-Levy, Anton N Isaacs, Heather Bridgman, Sarah J Lutkin, Timothy A Carey, Kate G Schlicht, Zita P McCabe-Gusta, Elizabeth Martin, Lee A Martinez
CONTEXT: The significant impact of mental ill health in rural and remote Australia has been well documented. Included among innovative approaches undertaken to address this issue has been the Mental Health Academic (MHA) project, established in 2007. Funded by the Australian Government (Department of Health), this project was established as a component of the University Departments of Rural Health (UDRH) program. All 11 UDRHs appointed an MHA. Although widely geographically dispersed, the MHAs have collaborated in various ways...
July 2016: Rural and Remote Health
Mihalj Poša, Ana Pilipović, Mirjana Bećarević, Zita Farkaš
Due to a relatively small size of bile acid salts, their mixed micelles with nonionic surfactants are analysed. Of the special interests are real binary mixed micelles that are thermodynamically more stable than ideal mixed micelles. Thermodynamic stability is expressed with an excess Gibbs energy (G(E)) or over an interaction parameter (βij). In this paper sodium salts of cholic (C) and hiodeoxycholic acid (HD) in their mixed micelles with Tween 40 (T40) are analysed by potentiometric titration and their pKa values are determined...
September 17, 2016: Steroids
Shaheen Pandie, Jonathan G Peter, Zita S Kerbelker, Richard Meldau, Grant Theron, Ureshnie Govender, Mpiko Ntsekhe, Keertan Dheda, Bongani M Mayosi
We evaluated the diagnostic accuracy of urinary and pericardial fluid (PF) lipoarabinomannan (LAM) assays in tuberculous pericarditis (TBP). From October 2009 through September 2012, 151 patients with TBP were enrolled. Mycobacterium tuberculosis culture and/or pericardial histology were the reference standard for definite TBP. 49% (74/151), 33.1% (50/151) and 17.9% (27/151) of patients had definite-, probable-, and non-TB respectively; 69.5% (105/151) were HIV positive. LAM ELISA had the following sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, positive predictive value and negative predictive values (95% confidence interval): urinary - 17...
2016: Scientific Reports
Dini Harsono, Carol L Galletly, Elaine O'Keefe, Zita Lazzarini
This review of literature identifies and describes US empirical studies on the criminalization of HIV exposure, examines findings on key questions about these laws, highlights knowledge gaps, and sets a course for future research. Studies published between 1990 and 2014 were identified through key word searches of relevant electronic databases and discussions with experts. Twenty-five empirical studies were identified. Sixteen of these studies used quantitative methods with more than half of these being cross-sectional survey studies...
September 7, 2016: AIDS and Behavior
Attila Körmendi, Zita Brutóczki, Bianka Petra Végh, Rita Székely
Background and aims The use of mobile phones has become an integral part of everyday life. Young people in particular can be observed using their smartphones constantly, and they not only make or receive calls but also use different applications or just tap touch screens for several minutes at a time. The opportunities provided by smartphones are attractive, and the cumulative time of using smartphones per day is very high for many people, so the question arises whether we can really speak of a mobile phone addiction? In this study, our aim is to describe and analyze a possible case of smartphone addiction...
September 2016: Journal of Behavioral Addictions
Vida Mildaziene, Giedre Pauzaite, Asta Malakauskiene, Rasa Zukiene, Zita Nauciene, Irina Filatova, Viktor Azharonok, Veronika Lyushkevich
Radiofrequency (5.28 MHz) electromagnetic radiation and low-temperature plasma were applied as short-term (2-15 min) seed treatments to two perennial woody plant species, including Smirnov's rhododendron (Rhododendron smirnowii Trautv.) and black mulberry (Morus nigra L.). Potential effects were evaluated using germination indices and morphometry. The results suggest that treatment with electromagnetic field stimulated germination of freshly harvested R. smirnowii seeds (increased germination percentage up to 70%), but reduced germination of fresh M...
August 30, 2016: Bioelectromagnetics
Klára Piukovics, Gabriella Terhes, Ágnes Bereczki, Zita Borbényi, Tímea Gurbity Pálfi, Bence Kővári, Edit Urbán
INTRODUCTION: Because of the use of chemo-immunotherapeutic drugs, cytomegalovirus infection is one of the most important infectious complications among patients with haematological malignancies. AIM: The aim of the authors was to detect cytomegalovirus infection and reactivation using quantitative real-time polymerase chain reaction. METHOD: Between 2012 and 2014, the authors retrospectively analysed 96 patient's medical history hospitalised in haematology Unit...
August 2016: Orvosi Hetilap
Simon Flury, Stefanie Zita Schmidt, Anne Peutzfeldt, Adrian Lussi
The aim was to investigate dentin bond strength of two resin-ceramic materials and five cements after 24 h and six months storage. Cylinders (n=15/group) of Lava Ultimate (3M ESPE) and VITA ENAMIC (VITA Zahnfabrik) were cemented to mid-coronal dentin of 300 extracted human molars with RelyX Ultimate (3M ESPE), PANAVIA F2.0 (Kuraray), Variolink II (Ivoclar Vivadent), els cem (Saremco Dental), or Ketac Cem Plus (3M ESPE). Shear bond strength (SBS) was measured after 24 h or six months storage (37°C, 100% humidity) and statistically analyzed (significance level: α=0...
October 1, 2016: Dental Materials Journal
Miklós Poór, Zita Zrínyi, Tamás Kőszegi
Dietary flavonoids are abundant in the Plant Kingdom and they are extensively studied because of their manifold pharmacological activities. Recent studies highlighted that cell cycle arrest plays a key role in their antiproliferative effect in different tumor cells. However, structure-activity relationship of flavonoids is poorly characterized. In our study the influence of 18 flavonoid aglycones (as well as two metabolites) on cell cycle distribution was investigated. Since flavonoids are extensively metabolized by liver cells, HepG2 tumor cell line was applied, considering the potential metabolic activation/inactivation of flavonoids...
August 11, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Antoine Edu, Cristina Teodorescu, Carmen Gabriela Dobjanschi, ZiŢa Zsuzsana Socol, Valeriu Teodorescu, Alexandru Matei, Dinu Florin Albu, Gabriela Radulian
Placental damage may be responsible for the fetal complications in pregnancies complicated by diabetes. We have analyzed the prevalence of gestational diabetes (GD) in a population of 109 pregnant women, the risk factors and the placental changes associated with gestational diabetes. Tests carried out were oral glucose tolerance test at 24-28 weeks of gestation, using the IADPSG (International Association of Diabetes and Pregnancy Study Groups) criteria for gestational diabetes, glycated hemoglobin, fasting insulin, total cholesterol, high density lipoprotein (HDL)-cholesterol, low density lipoprotein (LDL)-cholesterol, triglycerides, two-dimensional (2D) ultrasound and, also, there were analyzed macro and microscopic placental fragments from pregnant women with÷without GD...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Zita M Jessop, Ayesha Al-Sabah, Wendy R Francis, Iain S Whitaker
Regenerative medicine therapies, underpinned by the core principles of rejuvenation, regeneration and replacement, are shifting the paradigm in healthcare from symptomatic treatment in the 20th century to curative treatment in the 21st century. By addressing the reasons behind the rapid expansion of regenerative medicine research and presenting an overview of current clinical trials, we explore the potential of regenerative medicine to reshape modern healthcare.
2016: BMC Medicine
Zita Herczeg, Melinda Vanya, Károly Szili, Csilla Dézsi, Zsolt Nagy, János Szabó
The development of polycystic ovary syndrome and its exact pathophysiological mechanism is still unclear, but environmental and genetic factors likely play a role. Exposition to teratogenic effects during the prenatal development can lead to chronic diseases in the postnatal period. This finding confirms the common familial aggregation as well. A literature search was conducted up to January 1, 2016 for articles dealing with the genetic or epigenetic factors of polycystic ovary syndrome. This review will discuss the current understanding of the genetic basis and clinical presentation of this disease...
August 2016: Orvosi Hetilap
Liping Qiao, Jean-Sebastien Wattez, Samuel Lee, Zhuyu Guo, Jerome Schaack, William W Hay, Matteo Moretto Zita, Mana Parast, Jianhua Shao
AIMS/HYPOTHESIS: The main objective of this study was to investigate whether maternal adiponectin regulates fetal growth through the endocrine system in the fetal compartment. METHODS: Adiponectin knockout (Adipoq (-/-) ) mice and in vivo adenovirus-mediated reconstitution were used to study the regulatory effect of maternal adiponectin on fetal growth. Primary human trophoblast cells were treated with adiponectin and a specific peroxisome proliferator-activated receptor α (PPARα) agonist or antagonist to study the underlying mechanism through which adiponectin regulates fetal growth...
November 2016: Diabetologia
Kalman F Szucs, Aniko Nagy, Gyorgy Grosz, Zita Tiszai, Robert Gaspar
AIM: Gastrointestinal motility disorders are presumed to be associated with abnormalities of the generation of slow-wave electric impulses. A requirement for the development of non-invasive clinical methods for the diagnosis of motility disorders is the identification of these signals. We set out to separate and characterize the signals from the various sections of the gastrointestinal tract and to detect changes in the smooth muscle electromyography (SEMG) signals. METHODS: Partially resected (stomach-small intestine, stomach-large intestine or small and large intestine) or non-resected male SPRD rats were measured under deep anaesthesia...
July 27, 2016: Journal of Pharmacological and Toxicological Methods
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"