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https://www.readbyqxmd.com/read/29135289/-what-should-we-know-about-cardiac-amyloidosis-from-clinical-signs-to-treatment
#1
Dóra Földeák, Attila Nemes, Anita Kalapos, Péter Domsik, Árpád Kormányos, László Krenács, Enikő Bagdi, Zita Borbényi
Systemic amyloidosis is a rare disease, in which the heart involvement is rather frequent and determines survival remarkably. Regarding the disease and organ involvement, new diagnostic procedures help to establish the diagnosis and to start the adequate treatment as soon as possible. Cardiac involvement is more likely to be characterised by monoclonal immunglobulin free light chain (AL amyloidosis) type and transthyretin type. In case of AL amyloidosis, heart involvement can lead to serious consequences. Biomarker assessments for cardiac function are important to determine disease severity at the beginning and to measure response to the treatment...
November 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29097942/the-effect-of-diagnostic-imaging-on-surgical-treatment-planning-in-diseases-of-the-thymus
#2
REVIEW
Aurel Ottlakan, Bernadett Borda, Zita Morvay, Aniko Maraz, Jozsef Furak
Accurate imaging of the thymus is essential in the diagnosis and surgical treatment of both neoplastic and nonneoplastic conditions. Imaging of the thymus is a rather complex task, which affects both initial diagnosis and further surgical treatment planning. Imaging techniques include a wide armamentary of possibilities, from the most frequently used computed tomography (CT) to 18-fluorodeoxyglucose positron emission tomography- (18-FDG-PET-) CT and chemical shift magnetic resonance imaging (CS-MRI). In cases where surgical treatment is involved diagnostic imaging is of pivotal importance, not only in distinguishing benign from malignant disease but also in making a way among subtypes of thymic conditions...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29092115/cardiac-amyloidosis-associated-with-enlargement-and-functional-impairment-of-the-mitral-annulus-insights-from-the-three-dimensional-speckle-tracking-echocardiographic-magyar-path-study
#3
Attila Nemes, Dóra Földeák, Árpád Kormányos, Péter Domsik, Anita Kalapos, Zita Borbényi, Tamás Forster
BACKGROUND: Cardiac amyloidosis (CA) is a rare condition characterized by the extracellular deposition of amyloidogenic proteins in the heart. The aim of the present study was to compare the size and function of the mitral annulus (MA) between CA patients and age- and gender-matched controls, using three-dimensional speckle-tracking echocardiography (3-D STE). METHODS: The study included 17 patients (mean age 64.2 ± 9.8 years) with CA, whose results were compared to 26 age- and gender-matched healthy controls (mean age 59...
May 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29081883/diabetes-related-induction-of-the-heme-oxygenase-system-and-enhanced-colocalization-of-heme-oxygenase-1-and-2-with-neuronal-nitric-oxide-synthase-in-myenteric-neurons-of-different-intestinal-segments
#4
Lalitha Chandrakumar, Mária Bagyánszki, Zita Szalai, Diána Mezei, Nikolett Bódi
Increase in hyperglycaemia-induced oxidative stress and decreased effectiveness of endogenous defense mechanisms plays an essential role in the initiation of diabetes-related neuropathy. We demonstrated that nitrergic myenteric neurons display different susceptibilities to diabetic damage in different gut segments. Therefore, we aim to reveal the gut segment-specific differences in the expression of heme oxygenase (HO) isoforms and the colocalization of these antioxidants with neuronal nitric oxide synthase (nNOS) in myenteric neurons...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29077265/chemical-approach-to-biological-safety-molecular-level-control-of-an-integrated-zinc-finger-nuclease
#5
Eszter Németh, Masamitsu Asaka, Kohsuke Kato, Zita Fabian, Chris Oostenbrink, Hans Christensen, Kyosuke Nagata, Bela Gyurcsik
Application of artificial nucleases (ANs) in genome editing is still hindered by their cytotoxicity, related to off-target cleavages. This problem could be targeted by the regulation of the nuclease domain. Here we provide the experimental survey of computationally designed integrated zinc finger nucleases, constructed by linking the inactivated catalytic centre and the allosteric activator sequence of the colicin E7 nuclease domain to the two opposite termini of a zinc finger array. DNA-specificity and metal binding were confirmed by electrophoretic mobility shift assays, synchrotron radiation circular dichroism spectroscopy and nano-electrospray ionization mass spectrometry...
October 27, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29073650/the-cognitive-map-in-humans-spatial-navigation-and-beyond
#6
REVIEW
Russell A Epstein, Eva Zita Patai, Joshua B Julian, Hugo J Spiers
The 'cognitive map' hypothesis proposes that brain builds a unified representation of the spatial environment to support memory and guide future action. Forty years of electrophysiological research in rodents suggest that cognitive maps are neurally instantiated by place, grid, border and head direction cells in the hippocampal formation and related structures. Here we review recent work that suggests a similar functional organization in the human brain and yields insights into how cognitive maps are used during spatial navigation...
October 26, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/29069637/redox-active-metals-and-h2o2-mediate-the-increased-efficacy-of-pharmacological-ascorbate-in-combination-with-gemcitabine-or-radiation-in-pre-clinical-sarcoma-models
#7
Joshua D Schoenfeld, Zita A Sibenaller, Kranti A Mapuskar, Megan D Bradley, Brett A Wagner, Garry R Buettner, Varun Monga, Mohammed Milhem, Douglas R Spitz, Bryan G Allen
Soft tissue sarcomas are a histologically heterogeneous group of rare mesenchymal cancers for which treatment options leading to increased overall survival have not improved in over two decades. The current study shows that pharmacological ascorbate (systemic high dose vitamin C achieving ≥ 20mM plasma levels) is a potentially efficacious and easily integrable addition to current standard of care treatment strategies in preclinical models of fibrosarcoma and liposarcoma both in vitro and in vivo. Furthermore, enhanced ascorbate-mediated toxicity and DNA damage in these sarcoma models were found to be dependent upon H2O2 and intracellular labile iron...
September 28, 2017: Redox Biology
https://www.readbyqxmd.com/read/29064094/cardiac-amyloidosis-is-associated-with-increased-aortic-stiffness
#8
Attila Nemes, Dóra Földeák, Péter Domsik, Anita Kalapos, Árpád Kormányos, Zita Borbényi, Tamás Forster
OBJECTIVE: Cardiac amyloidosis (CA) is as an infiltrative disorder primarily caused by extracellular tissue deposition of amyloid fibrils in the myocardial interstitium. The current study was designed to test whether alterations in ascending aortic elastic properties could be detected by echocardiography in CA patients, and to compare their results to controls. PATIENTS AND METHODS: We included 19 CA patients from which CA proved to be AL amyloidosis in 17 cases and transthyretin (TTR) amyloidosis in 2 cases...
October 24, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29058251/cutaneous-lesions-and-disorders-in-healthy-neonates-and-their-relationships-with-maternal-neonatal-factors-a-cross-sectional-study
#9
Rita Ábrahám, Angéla Meszes, Zita Gyurkovits, Judit Bakki, Hajnalka Orvos, Zsanett Renáta Csoma
BACKGROUND: Cutaneous lesions are very common in neonates. Although a number of studies have reported on their incidence, very little is known about the factors that influence them. We set out to investigate a large population of neonates with the aims of achieving an overall picture of neonatal skin manifestations, and examining their relationships with various maternal, neonatal and perinatal factors. METHODS: This study was conducted on neonates born at the Department of Obstetrics and Gynaecology at the University of Szeged between June 2013 and July 2015...
December 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29057993/multiflexx-the-new-multi-analyzer-at-the-cold-triple-axis-spectrometer-flexx
#10
Felix Groitl, Rasmus Toft-Petersen, Diana Lucia Quintero-Castro, Siqin Meng, Zhilun Lu, Zita Huesges, Manh Duc Le, Svyatoslav Alimov, Thomas Wilpert, Klaus Kiefer, Sebastian Gerischer, Alexandre Bertin, Klaus Habicht
The first experimental characterization of a multiple energy analysis wide angle backend for a cold triple-axis spectrometer is reported. The multi-analyzer module MultiFLEXX employs 155 detection channels which simultaneously probe an extensive range in wavevector and energy transfer. Successful mapping of magnetic excitations in MnF2 and Ho demonstrate order of magnitude gains in data collection efficiency using this novel type backend. MultiFLEXX is competitive to standard triple-axis spectroscopy in terms of energy resolution and signal-to-noise ratio...
October 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29055476/prevalence-of-cognitive-impairment-among-hungarian-patients-with-relapsing-remitting-multiple-sclerosis-and-clinically-isolated-syndrome
#11
Dániel Sandi, Tamás Biernacki, Dóra Szekeres, Judit Füvesi, Zsigmond Tamás Kincses, Csilla Rózsa, Klotild Mátyás, Krisztián Kása, Judit Matolcsi, Dóra Zboznovits, Zita Burány, Éva Langane, László Vécsei, Krisztina Bencsik
BACKGROUND: Cognitive impairment (CI) is a frequent symptom of multiple sclerosis (MS); its prevalence is reported to be 43-70%. It is one of the most important determinants of MS patients' quality of life, as it is one of the main factors for MS patients becoming unemployed. AIM: We aimed to determine the prevalence of CI among the relapsing-remitting MS (RRMS) and clinically isolated syndrome (CIS) patients in Hungary, to evaluate the predicting factors of CI and to assess the differences between sexes and patients with different educational levels...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29045313/importance-of-axial-length-and-functional-corneal-endothelial-cells-in-descemet-membrane-endothelial-keratoplasty
#12
Davide Borroni, Melanie Ferronato, Zita Krumina, Mohit Parekh
No abstract text is available yet for this article.
December 2017: Cornea
https://www.readbyqxmd.com/read/29025290/-editor-s-commentary
#13
Zita Borbényi
No abstract text is available yet for this article.
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29025288/-state-of-the-art-molecular-diagnostics-and-therapy-of-chronic-lymphocytic-leukaemia-in-the-era-of-new-targeted-therapies
#14
Tímea Gurbity Pálfi, Viktória Fésüs, Csaba Bödör, Zita Borbényi
Chronic lymphoid leukaemia (CLL) has a heterogeneous clinical course depending on many clinical and molecular prognostic markers, which play an important role in the selection of the best treatment option. So far, TP53 disruption is the key prognostic and predictive factor assisting treatment decisions, especially in the era of novel therapies. Asymptomatic patients in early stages of the disease will still benefit from watchful waiting. In the frontline setting, chemoimmunotherapy is still the standard care in the majority of standard risk CLL patients...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29025287/-incidence-and-treatment-of-extranodal-natural-killer-t-cell-lymphoma-nasal-type-hungarian-experiences
#15
Annamária Bakos, Árpád Szomor, Tamás Schneider, Zsófia Miltényi, Imelda Marton, Zita Borbényi, Judit Pammer, László Krenács, Enikő Bagdi, Klára Piukovics
INTRODUCTION: Extranodal natural killer/T (NK/T) cell lymphoma, nasal type (ENKTL) represents a rare subtype of T-cell lymphomas with aggressive clinical behavior according to WHO 2016 classification. AIM: ENKTL has distinctive geographic distribution with higher incidence in Asia and Latin America (10% of all non-Hodgkin lymphoma cases), than in Europe and North America (<1%). ENKTL tipically origins from nasopharynx and upper aerodigestive tract. Anthracycline-based chemotherapy regimens are largely ineffective in the treatment of ENKTL...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29020319/tuberculosis-case-finding-with-combined-rapid-point-of-care-assays-xpert-mtb-rif-and-determine-tb-lam-in-hiv-positive-individuals-starting-antiretroviral-therapy-in-mozambique
#16
Marco Floridia, Fausto Ciccacci, Mauro Andreotti, Archa Hassane, Zita Sidumo, Nurja A Magid, Horacio Sotomane, Muhlavasse David, Elsa Mutemba, Junia Cebola, Remigio Josè Mugunhe, Fabio Riccardi, Maria Cristina Marazzi, Marina Giuliano, Leonardo Palombi, Sandro Mancinelli
Background: Tuberculosis is a major health concern in several countries, and effective diagnostic algorithms for use in human immunodeficiency virus (HIV)-positive patients are urgently needed. Methods: At prescription of antiretroviral therapy, all patients in 3 Mozambican health centers were screened for tuberculosis, with a combined approach: World Health Organization (WHO) 4-symptom screening (fever, cough, night sweats, and weight loss), a rapid test detecting mycobacterial lipoarabinomannan in urine (Determine TB LAM), and a molecular assay performed on a sputum sample (Xpert MTB/RIF; repeated if first result was negative)...
November 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28979774/early-detection-of-acute-cisplatin-nephrotoxicity-interest-of-urinary-monitoring-of-proximal-tubular-biomarkers
#17
Valérian Bunel, Yasmina Tournay, Thomas Baudoux, Eric De Prez, Marie Marchand, Zita Mekinda, Raphaël Maréchal, Thierry Roumeguère, Marie-Hélène Antoine, Joëlle L Nortier
BACKGROUND: Renal toxicity induced by cisplatin (CisPt) is a clinical issue in patients with or without chronic kidney disease (CKD). Proximal tubular injury can result in acute kidney injury (AKI), which may compromise the course of chemotherapy and the prognosis. The purpose of this study was to investigate the time course of urinary markers of acute tubulotoxicity and to assess the usefulness of such monitoring in a routine clinical setting. METHODS: This work is an open prospective pilot study carried out among 23 patients receiving a platinum-based chemotherapy...
October 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28974112/concentration-does-matter-the-beneficial-and-potentially-harmful-effects-of-ascorbate-in-humans-and-plants
#18
Szilvia Zita Tóth, Tamás Lőrincz, András Szarka
SIGNIFICANCE: Ascorbate is an essential compound both in animals and plants, mostly due to its reducing properties, thereby playing a role in scavenging reactive oxygen species and acting as a cofactor in various enzymatic reactions. Recent Advances: Growing number of evidence show that excessive ascorbate accumulation may have negative effects on cellular functions both in humans and plants, inter alia it may negatively affect signaling mechanisms, cellular redox status and contribute to the production of reactive oxygen species via the Fenton reaction...
October 3, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28962685/compulsory-psychiatric-treatment-checklist-instrument-development-and-clinical-application
#19
Sofia Brissos, Filipe Vicente, João Miguel Oliveira, Gonçalo Santos Sobreira, Zita Gameiro, Cátia Alves Moreira, Mariana Pinto da Costa, Marta Queirós, Eva Mendes, Susana Renca, Henrique Prata-Ribeiro, Maurício Scopel Hoffmann, Fernando Vieira
Instruments designed to evaluate the necessity of compulsory psychiatric treatment (CPT) are scarce to non-existent. We developed a 25-item Checklist (scoring 0 to 50) with four clusters (Legal, Danger, Historic and Cognitive), based on variables identified as relevant to compulsory treatment. The Compulsory Treatment Checklist (CTC) was filled with information on case (n=324) and control (n=251) subjects, evaluated under the Portuguese Mental Health Act (Law 36/98), in three hospitals. For internal validation, we used Confirmatory Factor Analysis (CFA), testing unidimensional and bifactor models...
September 2017: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/28898615/breech-presentation-vaginal-versus-cesarean-delivery-which-intervention-leads-to-the-best-outcomes
#20
Andreia Fonseca, Rita Silva, Inês Rato, Ana Raquel Neves, Carla Peixoto, Zita Ferraz, Inês Ramalho, Ana Carocha, Nisa Félix, Sandra Valdoleiros, Ana Galvão, Daniela Gonçalves, Joana Curado, Maria João Palma, Isabel Lobo Antunes, Nuno Clode, Luís Mendes Graça
INTRODUCTION: The best route of delivery for the term breech fetus is still controversial. We aim to compare maternal and neonatal outcomes between vaginal and cesarean term breech deliveries. MATERIAL AND METHODS: Multicentric retrospective cohort study of singleton term breech fetuses delivered vaginally or by elective cesarean section from January 2012 - October 2014. Primary outcomes were maternal and neonatal morbidity or mortality. RESULTS: Sixty five breech fetuses delivered vaginally were compared to 1262 delivered by elective cesarean...
June 30, 2017: Acta Médica Portuguesa
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