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https://www.readbyqxmd.com/read/29650029/the-dose-distribution-in-dominant-intraprostatic-tumour-lesions-defined-by-multiparametric-mri-and-psma-pet-ct-correlates-with-the-outcome-in-patients-treated-with-primary-radiation-therapy-for-prostate-cancer
#1
Constantinos Zamboglou, Christina Marie Klein, Benedikt Thomann, Thomas Franz Fassbender, Hans C Rischke, Simon Kirste, Karl Henne, Natalja Volegova-Neher, Michael Bock, Mathias Langer, Philipp T Meyer, Dimos Baltas, Anca L Grosu
No abstract text is available yet for this article.
April 12, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29621319/dosimetric-impact-of-intra-fraction-prostate-motion-under-a-tumour-tracking-system-in-hypofractionated-robotic-radiosurgery
#2
Yuhei Koike, Iori Sumida, Hirokazu Mizuno, Hiroya Shiomi, Keita Kurosu, Seiichi Ota, Yasuo Yoshioka, Osamu Suzuki, Keisuke Tamari, Kazuhiko Ogawa
For CyberKnife-mediated prostate cancer treatment, a tumour-tracking approach is applied to correct the target location by acquiring X-ray images of implanted fiducial markers intermittently. This study investigated the dosimetric impact of intra-fraction prostate motion during CyberKnife treatment. We retrospectively analyzed 16 patients treated using the CyberKnife (35 Gy delivered in five fractions). Using log files of recorded prostate motion, the intra-fraction prostate motion was simulated. We defined the worst-case intra-fraction prostate motion as the difference between pre- and post-deviation on log files and shifted structure sets according to the corresponding offsets for each beam...
2018: PloS One
https://www.readbyqxmd.com/read/29618488/steroid-sulfatase-inhibition-by-aryl-sulfamates-clinical-progress-mechanism-and-future-prospects
#3
Barry V L Potter
Steroid sulfatase is an emerging drug target for the endocrine therapy of hormone-dependent diseases, catalyzing estrogen sulfate hydrolysis to estrogen. Drug discovery, developing the core aryl O-sulfamate pharmacophore, has led to steroidal and non-steroidal drugs entering numerous clinical trials, with promising results in oncology and women's health. Steroidal estrogen sulfamate derivatives were the first irreversible active-site-directed inhibitors and one was developed clinically as an oral estradiol pro-drug and for endometriosis applications...
April 4, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29610463/single-cell-mrna-cytometry-via-sequence-specific-nanoparticle-clustering-and-trapping
#4
Mahmoud Labib, Reza M Mohamadi, Mahla Poudineh, Sharif U Ahmed, Ivaylo Ivanov, Ching-Lung Huang, Maral Moosavi, Edward H Sargent, Shana O Kelley
Cell-to-cell variation in gene expression creates a need for techniques that can characterize expression at the level of individual cells. This is particularly true for rare circulating tumour cells, in which subtyping and drug resistance are of intense interest. Here we describe a method for cell analysis-single-cell mRNA cytometry-that enables the isolation of rare cells from whole blood as a function of target mRNA sequences. This approach uses two classes of magnetic particles that are labelled to selectively hybridize with different regions of the target mRNA...
April 2, 2018: Nature Chemistry
https://www.readbyqxmd.com/read/29609897/increased-prostate-cancer-glucose-metabolism-detected-by-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-localised-gleason-8-10-prostate-cancers-identifies-very-high-risk-patients-for-early-recurrence-and-resistance-to-castration
#5
Etienne Lavallée, Michelle Bergeron, François-Alexandre Buteau, Annie-Claude Blouin, Nicolas Duchesnay, Thierry Dujardin, Rabi Tiguert, Louis Lacombe, Vincent Fradet, Molière Makao-Nguile, Yves Fradet, Jean-Mathieu Beauregard, Frédéric Pouliot
BACKGROUND: The accuracy of18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to stage prostate cancer (PCa) is limited. However, Gleason 8-10 PCa and more aggressive metastatic PCa have been shown to exhibit a higher glycolytic activity. OBJECTIVE: To evaluate the potential of intraprostatic FDG uptake to prognose Gleason 8-10 PCa patients prior to prostatectomy, based on tumour intrinsic biology. DESIGN, SETTING, AND PARTICIPANTS: FDG-PET/CT and a bone scan were performed as a staging procedure prior to prostatectomy in 148 consecutive patients diagnosed with PCa with a Gleason sum of ≥8 at biopsy...
March 30, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29607466/autophagy-inhibition-improves-the-chemotherapeutic-efficacy-of-cruciferous-vegetable-derived-diindolymethane-in-a-murine-prostate-cancer-xenograft-model
#6
Hossam Draz, Alexander A Goldberg, Emma S Tomlinson Guns, Ladan Fazli, Stephen Safe, J Thomas Sanderson
Prostate cancer is the second leading cause of cancer-related deaths in men in North America and there is an urgent need for development of more effective therapeutic treatments against this disease. We have recently shown that diindolylmethane (DIM) and several of its halogenated derivatives (ring-DIMs) induce death and protective autophagy in human prostate cancer cells. However, the in vivo efficacy of ring-DIMs and the use of autophagy inhibitors as adjuvant therapy have not yet been studied in vivo. The objective of this study was to determine these effects on tumor growth in nude CD-1 mice bearing bioluminescent androgen-independent PC-3 human prostate cancer cells...
April 2, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29606109/neoadjuvant-degarelix-with-or-without-apalutamide-followed-by-radical-prostatectomy-for-intermediate-and-high-risk-prostate-cancer-arneo-a-randomized-double-blind-placebo-controlled-trial
#7
Lorenzo Tosco, Annouschka Laenen, Thomas Gevaert, Isabelle Salmon, Christine Decaestecker, Elai Davicioni, Christine Buerki, Frank Claessens, Johan Swinnen, Karolien Goffin, Raymond Oyen, Wouter Everaerts, Lisa Moris, Gert De Meerleer, Karin Haustermans, Steven Joniau
BACKGROUND: Recent retrospective data suggest that neoadjuvant androgen deprivation therapy can improve the prognosis of high-risk prostate cancer (PCa) patients. Novel androgen receptor pathway inhibitors are nowadays available for treatment of metastatic PCa and these compounds are promising for early stage disease. Apalutamide is a pure androgen antagonist with a very high affinity with the androgen receptor. The combination of apalutamide with degarelix, an LHRH antagonist, could increase the efficacy compared to degarelix alone...
April 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29602695/-radiotherapy-of-bone-metastases-in-france-a-descriptive-monocentric-retrospective-study
#8
C Le Fèvre, D Antoni, A Thiéry, A Keller, P Truntzer, C Vigneron, J-B Clavier, S Guihard, M Pop, C Schumacher, P Salze, G Noël
PURPOSE: Bone metastases cause pain and affect patients' quality of life. Radiation therapy is one of the reference analgesic treatments. The objective of this study was to compare the current practices of a French radiotherapy department for the treatment of uncomplicated bone metastases with data from the literature in order to improve and optimize the management of patients. MATERIAL AND METHODS: A retrospective monocentric study of patients who underwent palliative irradiation of uncomplicated bone metastases was performed...
March 27, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29598981/factors-influencing-men-s-choice-of-and-adherence-to-active-surveillance-for-low-risk-prostate-cancer-a-mixed-method-systematic-review
#9
REVIEW
Netty Kinsella, Pär Stattin, Declan Cahill, Christian Brown, Anna Bill-Axelson, Ola Bratt, Sigrid Carlsson, Mieke Van Hemelrijck
CONTEXT: Despite support for active surveillance (AS) as a first treatment choice for men with low-risk prostate cancer (PC), this strategy is largely underutilised. OBJECTIVE: To systematically review barriers and facilitators to selecting and adhering to AS for low-risk PC. EVIDENCE ACQUISITION: We searched PsychINFO, PubMed, Medline 2000-now, Embase, CINAHL, and Cochrane Central databases between 2002 and 2017 using the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement...
March 26, 2018: European Urology
https://www.readbyqxmd.com/read/29593338/the-effect-of-selection-and-referral-biases-for-the-treatment-of-localised-prostate-cancer-with-surgery-or-radiation
#10
Christopher J D Wallis, Gerard Morton, Sender Herschorn, Ronald T Kodama, Girish S Kulkarni, Sree Appu, Bobby Shayegan, Roger Buckley, Arthur Grabowski, Steven A Narod, Robert K Nam
BACKGROUND: Consultation with radiation oncologists, in addition to urologists, is advocated for patients diagnosed with prostate cancer. Treatment patterns for patients receiving consultation from radiation oncologists in addition to urologists have not previously been described. METHODS: We conducted a matched cohort study of men with newly diagnosed non-metastatic prostate cancer in Ontario, Canada. Patients who underwent consultation with a radiation oncologist prior to treatment were matched 1:1 with patients managed by a urologist alone based on tumour and patient characteristics...
March 29, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29592867/periprostatic-fat-tissue-transciptome-reveals-a-signature-diagnostic-for-high-risk-prostate-cancer
#11
Stefano Mangiola, Ryan Stuchbery, Geoff Macintyre, Michael J Clarkson, Justin S Peters, Anthony J Costello, Christopher M Hovens, Niall M Corcoran
Evidence suggests that altered adipose tissue homeostasis may be an important contributor to the development and/or progression of prostate cancer. In this study we investigated the adipose transcriptional profiles of low- and high-risk disease to determine both prognostic potential and possible biological drivers of aggressive disease. RNA was extracted from periprostatic adipose tissue from patients categorised as having prostate cancer with either a high- or low-risk of progression based on tumour characteristics at prostatectomy and profiled by RNA sequencing...
March 28, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29587322/-the-role-of-biomarkers-in-the-diagnosis-prognosis-and-therapy-of-patients-with-immuno-oncological-treatments-of-genito-urinary-carcinomas
#12
Eva Compérat, Caroline Eymerit, Julien Moroch, Justin Varinot
In recent years, fundamental research has yielded new insights into tumour biology, and new treatments have been developed. This review highlights the role of the pathologist and how he can support clinicians to find the right treatment for each patient. We explain the problems of the molecular subgroups of bladder cancer, the role of neo-adjuvant chemotherapy in the context of these findings, and show the important role of checkpoint inhibitors. Furthermore we focus on kidney cancer, with the clear cell carcinoma as the most frequent tumour type...
April 2018: Aktuelle Urologie
https://www.readbyqxmd.com/read/29578193/interlink-between-cholesterol-cell-cycle-in-prostate-carcinoma
#13
Govind Singh, Shrimanjunath Sankanagoudar, Premnath Dogra, Nimai Chand Chandra
Background & objectives: Earlier reports have shown hypocholesterolaemia in cancer patients and high number of lipid rafts in cancer cells. The primary objective of this study was to compare the intracellular cholesterol turnover in non-cancerous (benign) prostatic hyperplasia (BPH) and carcinoma prostate (CAP) with normal prostate cells obtained from patients undergoing radical cystectomy for carcinoma bladder (sham control). Methods: ELISA-based estimation of prostate-specific antigen (PSA), evaluation of expression of low-density lipoprotein receptor (LDLR), peripheral-type benzodiazepine receptor (PBR) and cyclin E, immunohistochemistry and confocal microscopy, measurement of integrated optical density of the diaminobenzidine (DAB)-stained immunohistograms, isolation of nucleus and cell cytoplasm from prostate tissue by ultracentrifugation followed by estimation of cholesterol spectrophotometrically in isolated nuclear and cytoplasmic fractions were performed...
November 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29569717/the-effect-of-fasn-inhibition-on-the-growth-and-metabolism-of-a-cisplatin-resistant-ovarian-carcinoma-model
#14
Efthymia Papaevangelou, Gilberto S Almeida, Carol Box, Nandita M deSouza, Yuen-Li Chung
Overexpression of fatty acid synthase (FASN), a key regulator of the de novo synthesis of fatty acids, has been demonstrated in a variety of cancers and is associated with poor prognosis and increased multidrug resistance. Inhibition of FASN with the anti-obesity drug orlistat has been shown to have significant anti-tumorigenic effects in many cancers, notably breast and prostate. In this study, we investigated whether FASN inhibition using orlistat is an effective adjunctive treatment for ovarian cancers that have become platinum resistant using a cisplatin-resistant ovarian tumour xenograft model in mice...
March 23, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29567887/role-of-nm23h1-in-predicting-metastases-in-prostatic-carcinoma
#15
Arvind Kumar, Deepa Hatwal, Neha Batra, Nidhi Verma
Background: Non-metastatic nm23H1 gene is thought to play a critical role in cell proliferation. Studies of nm23H1 have been done in many other malignancies. But none of these studies took up nm23H1 gene as predictor in the metastases of prostatic carcinoma. Aims and Objectives: To study the expression of nm23H1 in prostatic lesion and to correlate nm23H1 expression with presence of metastases, tumour stage, tumour grade and with PSA level serum. Setting and Design: Tertiary hospital based retrospective and prospective study done in a period of one year from thirty patients having prostatic lesion confirmed by biopsy...
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29565650/recent-advances-in-theranostics-and-challenges-for-the-future
#16
J Harvey Turner
Theranostic nuclear oncology is on the cusp of adoption into routine clinical management of neuroendocrine tumours (NETs) following publication of the Phase 3 randomized controlled trial, NETTER-1. For the first time, level 1b evidence of efficacy and safety of 68-gallium/177 lutetium-DOTA-octreotatepeptide receptor radionuclide therapy (PRRT), of midgut NETs was established. Multicentre Phase 2 studies of 68-gallium/177 lutetium-PSMA theranostic approaches to management of end-stage metastatic castrate-resistant prostate cancer (mCRPC), are also very encouraging...
March 22, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29563633/fasting-blood-glucose-glycaemic-control-and-prostate-cancer-risk-in-the-finnish-randomized-study-of-screening-for-prostate-cancer
#17
Teemu J Murtola, Ville Jy Vihervuori, Jorma Lahtela, Kirsi Talala, Kimmo Taari, Teuvo Lj Tammela, Anssi Auvinen
BACKGROUND: Diabetic men have lowered overall risk of prostate cancer (PCa), but the role of hyperglycaemia is unclear. In this cohort study, we estimated PCa risk among men with diabetic fasting blood glucose level. METHODS: Participants of the Finnish Randomized Study of Screening for Prostate Cancer (FinRSPC) were linked to laboratory database for information on glucose measurements since 1978. The data were available for 17,860 men. Based on the average yearly level, the men were categorised as normoglycaemic, prediabetic, or diabetic...
March 22, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29563505/identification-of-sarcosine-as-a-target-molecule-for-the-canine-olfactory-detection-of-prostate-carcinoma
#18
Dalibor Pacik, Mariana Plevova, Lucie Urbanova, Zuzana Lackova, Vladislav Strmiska, Alois Necas, Zbynek Heger, Vojtech Adam
The hypothesis that dogs can detect malignant tumours through the identification of specific molecules is nearly 30 years old. To date, several reports have described the successful detection of distinct types of cancer. However, is still a lack of data regarding the specific molecules that can be recognized by a dog's olfactory apparatus. Hence, we performed a study with artificially prepared, well-characterized urinary specimens that were enriched with sarcosine, a widely reported urinary biomarker for prostate cancer (PCa)...
March 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29556050/versatile-protein-recognition-by-the-encoded-display-of-multiple-chemical-elements-on-a-constant-macrocyclic-scaffold
#19
Yizhou Li, Roberto De Luca, Samuele Cazzamalli, Francesca Pretto, Davor Bajic, Jörg Scheuermann, Dario Neri
In nature, specific antibodies can be generated as a result of an adaptive selection and expansion of lymphocytes with suitable protein binding properties. We attempted to mimic antibody-antigen recognition by displaying multiple chemical diversity elements on a defined macrocyclic scaffold. Encoding of the displayed combinations was achieved using distinctive DNA tags, resulting in a library size of 35,393,112. Specific binders could be isolated against a variety of proteins, including carbonic anhydrase IX, horseradish peroxidase, tankyrase 1, human serum albumin, alpha-1 acid glycoprotein, calmodulin, prostate-specific antigen and tumour necrosis factor...
April 2018: Nature Chemistry
https://www.readbyqxmd.com/read/29548559/influence-of-inhomogeneous-radiosensitivity-distributions-and-intrafractional-organ-movement-on-the-tumour-control-probability-of-focused-imrt-in-prostate-cancer
#20
Benedikt Thomann, Ilias Sachpazidis, Khodor Koubar, Constantinos Zamboglou, Panayiotis Mavroidis, Rolf Wiehle, Anca-Ligia Grosu, Dimos Baltas
PURPOSE: To evaluate the influence of radioresistance and intrafractional movement on the tumour control probability (TCP) in IMRT prostate treatments using simultaneous integrated boosts to PSMA-PET/CT-delineated GTVs. MATERIALS AND METHODS: 13 patients had PSMA-PET/CT prior to prostatectomy and histopathological examination. Two GTVs were available: GTV-PET and GTV-histo, which is the true cancer volume. Focused IMRT plans delivering 77 Gy in 35 fractions to the prostate and 95 Gy to PTV-PET were produced...
March 13, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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