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pseudomonas keratitis

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https://www.readbyqxmd.com/read/29913556/immunoregulatory-role-of-15-lipoxygenase-in-the-pathogenesis-of-bacterial-keratitis
#1
Thomas W Carion, Matthew Greenwood, Abdul Shukkur Ebrahim, Andrew Jerome, Susmit Suvas, Karsten Gronert, Elizabeth A Berger
Although autacoids primarily derived from the cyclooxygenase-2 and 5-lipoxygenase (LOX) pathways are essential mediators of inflammation, endogenous specialized proresolving mediators (SPMs) act as robust agonists of resolution. SPM biosynthesis is initiated by the conversion of arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid primarily via the 12/15-LOX pathway. Although 12/15-LOX activity is prominent in the cornea, the role of SPM pathway activation during infection remains largely unknown and is the focus of the current study...
April 13, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29891552/opposing-effects-of-il-1ra-and-il-36ra-on-innate-immune-response-to-pseudomonas-aeruginosa-infection-in-c57bl-6-mouse-corneas
#2
Nan Gao, Rao Me, Chenyang Dai, Berhane Seyoum, Fu-Shin X Yu
Pseudomonas aeruginosa keratitis is characterized by severe corneal ulceration and may lead to blindness if not treated properly in a timely manner. Although the roles of the IL-1 subfamily of cytokines are well established, as a newly discovered subfamily, IL-36 cytokine regulation, immunological relevance, and relation with IL-1 cytokines in host defense remain largely unknown. In this study, we showed that P. aeruginosa infection induces the expression of IL-36α and IL-36γ, as well as IL-1β and secreted IL-1Ra (sIL-1Ra), but not IL-36Ra...
June 11, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29887864/triggering-receptors-expressed-on-myeloid-cells-2-promotes-corneal-resistance-against-pseudomonas-aeruginosa-by-inhibiting-caspase-1-dependent-pyroptosis
#3
Wenting Qu, Yi Wang, Yongjian Wu, Yiting Liu, Kang Chen, Xi Liu, Zhengyu Zou, Xi Huang, Minhao Wu
Triggering receptors expressed on myeloid cells 2 (TREM2) is a novel cell surface receptor and functions as an immunomodulatory receptor in infectious diseases. In this study, we investigated the function and regulatory mechanism of TREM2 in Pseudomonas aeruginosa ( P. aeruginosa ) keratitis. We found that P. aeruginosa keratitis was more severe in Trem2 -/- versus wild type C57BL/6 mice as indicated by the increased clinical scores, bacterial load, and cornea pathology. The exacerbated disease progression caused by TREM2 deficiency was associated with boosted activation of caspase-1 and subsequent pyroptosis as well as increased expression of IL-1β...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29851781/acute-exacerbation-of-staphylococcal-catarrhal-infiltration-associated-with-treatment-for-pseudomonas-aeruginosa-keratitis-a-case-report
#4
Seung Pil Bang, Jong Hwa Jun
RATIONALE: Simultaneous presentation of peripheral infiltrates, which can be easily misidentified as satellite lesions, is rarely observed in patients with acute infectious keratitis. PATIENT CONCERNS: A 70-year-old woman was referred to our clinic due to acute mucopurulent keratitis following application of a therapeutic soft contact lens for the treatment of epithelial defects caused by entrance of soil foreign bodies into the eye. The patient was diagnosed with Pseudomonas keratitis, following which she was treated with alternating administration of fourth-generation fluoroquinolone (Vigamox) and 5% fortified ceftazidime eyedrops every 2 hours...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29730068/biofilm-testing-of-microbiota-an-essential-step-during-corneal-scrap-examination-in-egyptian-acanthamoebic-keratitis-cases
#5
Marwa A Hasby Saad, Haidy S M Khalil
PURPOSE: To detect co-infections in the culture-proven acanthamoebic keratitis (AK) cases, and to test the capability of biofilm formation in the isolated microbiota. The clinical findings, habit of wearing contact lens and in-vitro antibiotic resistance were analyzed further according to the biofilm formation capability. METHODS: After clinical examination, corneal scraps and swabs were taken from 240 clinically suspected AK cases, for Acanthamoeba and microbiological cultures...
May 3, 2018: Parasitology International
https://www.readbyqxmd.com/read/29697492/acanthamoeba-an-overview-of-the-challenges-to-the-development-of-a-consensus-methodology-of-disinfection-efficacy-testing-for-contact-lens-care-products
#6
Jeffrey Brocious, Michelle E Tarver, Denise Hampton, Malvina Eydelman
With the increasing incidence of more pathogens that can cause microbial keratitis (MK), it is necessary to periodically reassess disinfection multipurpose solutions testing requirements to ensure that relevant organisms to challenge them are being used. Current testing protocols have included common pathogens such as Pseudomonas aeruginosa, Staphylococcus aureus, Serratia marcescens, Candida albicans, and Fusarium solani but have omitted less common pathogens such as Acanthamoeba. Specifically, Acanthamoeba sp...
April 24, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29589177/time-dependent-antimicrobial-effect-of-photodynamic-therapy-with-tons-504-on-pseudomonas-aeruginosa
#7
Kentaro Sueoka, Taiichiro Chikama, Miftahul Akhyar Latief, Ji-Ae Ko, Yoshiaki Kiuchi, Takemasa Sakaguchi, Akira Obana
Pseudomonas aeruginosa (P. aeruginosa) is a major cause of infectious keratitis, which itself is a major cause of blindness worldwide. We have now evaluated the time-dependent effectiveness of photodynamic antimicrobial chemotherapy (PACT) with the chlorin derivative TONS 504 and a light-emitting diode (LED) on P. aeruginosa in vitro. PACT with TONS 504 (10 mg/L) and irradiation (30 J/m2 ) by an LED device that delivers light centered on a wavelength of 660 nm was applied to 1 × 106 colony-forming units of P...
March 27, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29547943/nucleotide-sequence-analysis-of-nps-1-%C3%AE-lactamase-and-a-novel-integron-in1427-carrying-transposon-in-an-mdr-pseudomonas-aeruginosa-keratitis-strain
#8
Dinesh Subedi, Ajay Kumar Vijay, Gurjeet Singh Kohli, Scott A Rice, Mark Willcox
No abstract text is available yet for this article.
June 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29459431/comparative-activity-of-antimicrobials-against-pseudomonas-aeruginosa-achromobacter-xylosoxidans-and-stenotrophomonas-maltophilia-keratitis-isolates
#9
Oriel Spierer, Darlene Miller, Terrence P O'Brien
BACKGROUND/AIMS: Achromobacter xylosoxidans and Stenotrophomonas maltophilia are emerging corneal pathogens, which are closely related to Pseudomonas aeruginosa , and have intrinsic resistance to many commonly available antimicrobials. The purpose of this study is to compare the in vitro efficacy of 12 antimicrobial agents against A. xylosoxidans , S. maltophilia and P. aeruginosa isolates recovered from clinical cases of keratitis. METHODS: Recovered corneal isolates (n=58) were identified and extracted from the Microbiology Data Bank of the Bascom Palmer Eye Institute...
May 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29436623/development-of-uracil-dna-glycosylase-supplemented-loop-mediated-isothermal-amplification-coupled-with-nanogold-probe-udg-lamp-aunp-for-specific-detection-of-pseudomonas-aeruginosa
#10
Orapan Manajit, Siwaporn Longyant, Paisarn Sithigorngul, Parin Chaivisuthangkura
Pseudomonas aeruginosa (P. aeruginosa) is an important opportunistic pathogen that causes serious infections in humans, including keratitis in contact lens wearers. Therefore, establishing a rapid, specific and sensitive method for the identification of P. aeruginosa is imperative. In the present study, the uracil-DNA-glycosylase-supplemented loop-mediated isothermal amplification combined with nanogold labeled hybridization probe (UDG-LAMP-AuNP) was developed for the detection of P. aeruginosa. UDG-LAMP was performed to prevent carry over contamination and the LAMP reactions can be readily observed using the nanogold probe...
April 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29369234/in-vitro-evaluation-of-a-hypochlorous-acid-hygiene-solution-on-established-biofilms
#11
Eric G Romanowski, Nicholas A Stella, Kathleen A Yates, Kimberly M Brothers, Regis P Kowalski, Robert M Q Shanks
OBJECTIVES: The purpose of this study was to determine whether a commercial formulation of hypochlorous acid hygiene solution (0.01%), Avenova, can destroy existing biofilms formed by ocular clinical bacterial isolates, including blepharitis isolates of Staphylococcus aureus and coagulase-negative staphylococci, and a keratitis isolate of Pseudomonas aeruginosa. METHODS: Biofilms grown in bacterial growth media on disposable contact lens cases were challenged with hypochlorous acid hygiene solution...
January 15, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29346493/antimicrobial-studies-using-the-therapeutic-tissue-cross-linking-agent-sodium-hydroxymethylglycinate-implication-for-treating-infectious-keratitis
#12
Patrick B Rapuano, Alexandra H Scanameo, Daeryl E Amponin, Sefy A Paulose, Mariya Zyablitskaya, Anna Takaoka, Leejee H Suh, Takayuki Nagasaki, Stephen L Trokel, David C Paik
Purpose: Our recent studies raise the possibility of using sodium hydroxymethylglycinate (SMG), for pharmacologic therapeutic tissue cross-linking (TXL) of the cornea. The present study was performed to evaluate the antimicrobial effects of SMG for potential use in treating infectious keratitis. Methods: In initial (group 1) experiments, methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), and Pseudomonas aeruginosa (PA) were treated with SMG (10-40 mM) for 10 to 120 minutes...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29341837/ocular-permeation-of-topical-tazocin-and-its-effectiveness-in-the-treatment-of-pseudomonas-aeruginosa-induced-keratitis-in-rabbits
#13
Sujaya Singh, Renu Agarwal, Zulhilmi Abdul Razak, Robin Ngu, Lwin L Nyein, Sushil Vasudevan, Marina Kapitonova, Azida Juana Kadir, Subrayan Visvaraja
PURPOSE: Pseudomonas aeruginosa is the most common causative organism for contact lens-associated corneal ulcer and is commonly treated with fluoroquinolones. With the emergence of resistant strains, it is important to investigate alternative therapies. Despite well-established efficacy of tazocin against systemic Pseudomonas infections, its topical use for the treatment of Pseudomonas keratitis has not been described, hence this study was aimed to find the ocular permeation of Tazocin and its efficacy in treating keratitis in rabbit eyes...
January 17, 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29335265/contact-lens-related-pseudomonas-aeruginosa-keratitis-in-a-49-year-old-woman
#14
Harald Gjerde, Anuradha Mishra
No abstract text is available yet for this article.
January 15, 2018: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/29325116/differential-expression-of-antimicrobial-peptides-in-corneal-infection-and-regulation-of-antimicrobial-peptides-and-reactive-oxygen-species-by-type-iii-secretion-system-of-pseudomonas-aeruginosa
#15
Prerana Sharma, Sanjukta Guha, Prashant Garg, Sanhita Roy
Pseudomonas aeruginosa is an opportunistic pathogen and is the major cause of corneal infection worldwide that secret several virulent toxins through its type III secretion system (T3SS). In defense against pathogenic insults, epithelial cells and macrophages express antimicrobial peptides (AMPs) that are essential components of host immune response. In this study, we have determined the expression of several AMPs in patients with P. aeruginosa corneal infection. We also used an in vitro model of infection using human corneal epithelial cells and macrophages to determine the gene expression of AMPs and cellular response to wild-type and T3SS mutant P...
February 1, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29278804/adherence-of-pseudomonas-aeruginosa-onto-surfactant-laden-contact-lenses
#16
Reynalyn Mosuela, Shelan Mustafa, Simon Gould, Hany Hassanin, Raid G Alany, Amr ElShaer
There is an immense research interest to utilise contact lens (CLs) as a popular platform for ocular drug delivery. However, CLs are the major predisposing factors of bacterial keratitis which is commonly caused by adhesion of microbes such as Pseudomonas aeruginosa and Staphylococcus epidermidis. The aim of the current study is to explore the effect of surfactants; Poloxamer 188, Polysorbate 80 and Tetronic® 90R4 (at 0.25% - 3% v/v) on the characteristics of CLs and on the adhesion abilities of Pseudomonas aeruginosa to the lenses' surfaces...
March 1, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29273244/bacterial-keratitis-treated-by-strengthened-antibiotic-eye-drops-an-18-months-review-of-clinical-cases-and-antibiotic-susceptibilities
#17
J Saillard, L Spiesser-Robelet, P Gohier, T Briot
PURPOSE: To describe, in patients treated for infectious keratitis, the microorganisms identified and their antibiotic susceptibility over a period of 18 months. METHOD: Retrospective, descriptive, non-comparative study. Medical and biological data were extracted from the patients' file treated with strengthened antibiotic eye drops at Angers University Hospital between January 2015 and June 2016. The main elements noted were the bacteria involved and their susceptibility to antibiotics...
March 2018: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/29242901/designed-host-defense-peptides-for-the-treatment-of-bacterial-keratitis
#18
L Edward Clemens, Jesse Jaynes, Edward Lim, Satya S Kolar, Rose Y Reins, Hasna Baidouri, Samuel Hanlon, Alison M McDermott, Kathryn W Woodburn
Purpose: To limit corneal damage and potential loss of vision, bacterial keratitis must be treated aggressively. Innovation in antimicrobials is required due to the need for empirical treatment and the rapid emergence of bacterial resistance. Designed host defense peptides (dHDPs) are synthetic analogues of naturally occurring HDPs, which provide defense against invading pathogens. This study investigates the use of novel dHDPs for the treatment of bacterial keratitis. Methods: The minimum inhibitory concentrations (MICs) were determined for dHDPs on both Gram-positive and -negative bacteria...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29236588/topical-glycyrrhizin-is-therapeutic-for-pseudomonas-aeruginosa-keratitis
#19
Sandamali A Ekanayaka, Sharon A McClellan, Ronald P Barrett, Linda D Hazlett
PURPOSE: Glycyrrhizin (GLY), an inhibitor of high-mobility group box 1 (HMGB1) protects prophylactically against Pseudomonas aeruginosa keratitis. However, the therapeutic potential of GLY to enhance an antibiotic has not been tested and is our purpose. METHODS: C57BL/6 mice (B6) were infected with a clinical isolate (KEI 1025) of P. aeruginosa and treated topically at 6 h postinfection (p.i.) with GLY or phosphate-buffered saline (PBS). Clinical scores, photography with a slit lamp, enzyme-linked immunosorbent assay, myeloperoxidase assay, bacterial plate counts, histopathology, reactive oxygen/nitrogen species (ROS/RNS) assays, and in vitro macrophage (Mφ) stimulation assays were used to assess effects of GLY treatment...
April 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29178851/bacterial-profile-of-ocular-infections-a-systematic-review
#20
REVIEW
Mebrahtu Teweldemedhin, Hailay Gebreyesus, Ataklti Hailu Atsbaha, Solomon Weldegebreal Asgedom, Muthupandian Saravanan
BACKGROUND: Bacteria are the major contributor of ocular infections worldwide. Ocular infections, if left untreated, can damage the structures of the eye with possible blindness and visual impairments. This work was aimed to review the bacterial profile of ocular infections. METHODS: Literature search was made in different electronic databases; the review was systematically made to get concrete findings. RESULTS: As far as this review, Staphylococcus aureus, Coagulase negative Staphylococci, Streptococcus pneumoniae and Pseudomonas aeruginosa are the leading isolates in ocular infections...
November 25, 2017: BMC Ophthalmology
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