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https://www.readbyqxmd.com/read/29161069/characteristics-of-hiv-positive-transgender-men-receiving-medical-care-united-states-2009-2014
#1
Ansley Lemons, Linda Beer, Teresa Finlayson, Donna Hubbard McCree, Daniel Lentine, R Luke Shouse
OBJECTIVES: To present the first national estimate of the sociodemographic, clinical, and behavioral characteristics of HIV-positive transgender men receiving medical care in the United States. METHODS: This analysis included pooled interview and medical record data from the 2009 to 2014 cycles of the Medical Monitoring Project, which used a 3-stage, probability-proportional-to-size sampling methodology. RESULTS: Transgender men accounted for 0...
November 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29161011/the-design-of-plasmodium-vivax-hypoxanthine-guanine-phosphoribosyltransferase-inhibitors-as-potential-antimalarial-therapeutics
#2
Dianne T Keough, Dominik Rejman, Radek Pohl, Eva Zborníková, Dana Hockova, Tristan Croll, Michael D Edstein, Geoff W Birrell, Marina Chavchich, Lieve M J Naesens, Gregory K Pierens, Ian M Brereton, Luke W Guddat
Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) are the foremost causative agents of malaria. Due to the development of resistance to current antimalarial medications, new drugs for this parasitic disease need to be discovered. The activity of hypoxanthine-guanine-[xanthine]-phosphoribosyltransferase, HG[X]PRT, is reported to be essential for the growth of both of these parasites, making it an excellent target for antimalarial drug discovery. Here, we have used rational structure-based methods to design an inhibitor, [3R,4R]-4-guanin-9-yl-3-((S)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine, of PvHGPRT and PfHGXPRT which has Ki values of 8 nM and 7 nM, respectively for these two enzymes...
November 21, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29160116/assessment-of-aav-serotype-tropism-in-human-retinal-explants
#3
Luke Aaron Wiley, Erin Burnight, Emily E Kaalberg, Chunhua Jiao, Megan J Riker, Jennifer A Halder, Meagan A Luse, Ian C Han, Stephen R Russell, Elliott H Sohn, Edwin Stone, Budd A Tucker, Robert F Mullins
Advances in the discovery of the causes of monogenic retinal disorders, combined with technologies for the delivery of DNA to the retina, offer enormous opportunities for the treatment of previously untreatable blinding diseases. However, for gene augmentation to be most effective, vectors that have the correct cell-type specificity are needed. While animal models are very useful, they often exhibit differences in retinal cell surface receptors compared to human retina. In this study, we evaluated the use of an ex vivo organotypic explant system to test the transduction efficiency and tropism of 7 different adeno-associated viral type 2 (AAV2) serotypes in human retina and retinal pigment epithelium-choroid: AAV2/1, AAV2/2, AAV2/4, AAV2/5, AAV2/6, AAV2/8, and AAV2/9, all driving expression of GFP under control of the cytomegalovirus promoter...
November 21, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/29156946/chondroprotection-in-models-of-cartilage-injury-by-raising-the-temperature-and-osmolarity-of-irrigation-solutions
#4
Noha M Eltawil, Saima Ahmed, Luke H Chan, A Hamish R W Simpson, Andrew C Hall
Objectives During arthroscopic or open joint surgery, articular cartilage may be subjected to mechanical insults by accident or design. These may lead to chondrocyte death, cartilage breakdown and posttraumatic osteoarthritis. We have shown that increasing osmolarity of routinely used normal saline protected chondrocytes against injuries that may occur during orthopedic surgery. Often several liters of irrigation fluid are used during an orthopedic procedure, which is usually kept at room temperature, but is sometimes chilled...
January 1, 2017: Cartilage
https://www.readbyqxmd.com/read/29155998/limited-impact-of-adolescent-meningococcal-acwy-vaccination-on-group-w-carriage-in-university-students
#5
Neil J Oldfield, Luke R Green, Julian Parkhill, Christopher D Bayliss, David P J Turner
Background: In the UK rising disease levels due to Neisseria meningitidis serogroup W clonal complex ST-11 (MenW:cc11) strains led to introduction of conjugate MenACWY vaccination for teenagers. We investigated the impact of immunization on carriage of targeted meningococci by whole genome sequencing of isolates recovered from a cohort of vaccinated university students. Methods: Strain designation data were extracted from whole genome sequence data. Genomes from carried and invasive MenW:cc11 were compared using a gene-by-gene approach...
November 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29155228/barriers-and-facilitators-to-the-implementation-of-physical-activity-policies-in-schools-a-systematic-review
#6
REVIEW
Nicole Nathan, Ben Elton, Mark Babic, Nicole McCarthy, Rachel Sutherland, Justin Presseau, Kirsty Seward, Rebecca Hodder, Debbie Booth, Sze Lin Yoong, Luke Wolfenden
Research consistently indicates that schools fail to implement mandatory physical activity policies. This review aimed to describe factors (barriers and facilitators) that may influence the implementation of school physical activity policies which specify the time or intensity that physical activity should be implemented and to map these factors to a theoretical framework. A systematic search was undertaken in six databases for quantitative or qualitative studies published between 1995-March 2016 that examined teachers', principals' or school administrators' reported barriers and/or facilitators to implementing mandated school physical activity policies...
November 16, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29155139/the-generation-and-characterisation-of-neutralising-antibodies-against-the-theiler-s-murine-encephalomyelitis-virus-tmev-gdvii-capsid-reveals-the-potential-binding-site-of-the-host-cell-co-receptor-heparan-sulfate
#7
Nicole Upfold, Caroline Ross, Özlem Tastan Bishop, Garry A Luke, Caroline Knox
The early stages of picornavirus capsid assembly and the host factors involved are poorly understood. Since the localisation of viral proteins in infected cells can provide information on their function, antibodies against purified Theiler's murine encephalomyelitis virus (TMEV) GDVII capsids were generated by immunisation of rabbits. The resultant anti-TMEV capsid antibodies recognised a C-terminal region of VP1 but not VP2 or VP3 by Western analysis. Examination of the sites of TMEV capsid assembly by indirect immunofluorescence and confocal microscopy showed that at 5hours post infection, capsid signal was diffusely cytoplasmic with strong perinuclear staining and moved into large punctate structures from 6 to 8hours post infection...
November 16, 2017: Virus Research
https://www.readbyqxmd.com/read/29154643/gender-nonconformity-of-identical-twins-with-discordant-sexual-orientations-evidence-from-childhood-photographs
#8
Tuesday M Watts, Luke Holmes, Jamie Raines, Sheina Orbell, Gerulf Rieger
Childhood gender nonconformity (femininity in males, masculinity in females) predicts a nonstraight (gay, lesbian, or bisexual) sexual orientation in adulthood. In previous work, nonstraight twins reported more childhood gender nonconformity than their genetically identical, but straight, cotwins. However, self-reports could be biased. We therefore assessed gender nonconformity via ratings of photographs from childhood and adulthood. These ratings came from independent observers naïve to study hypotheses. Identical twins with discordant sexual orientations (24 male pairs, 32 female pairs) visibly differed in their gender nonconformity from mid-childhood, with higher levels of gender nonconformity observed in the nonstraight twins...
November 20, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/29154627/distinct-kinematic-markers-of-demonstration-and-joint-action-coordination-evidence-from-virtual-xylophone-playing
#9
Luke McEllin, Günther Knoblich, Natalie Sebanz
When performing joint actions, people modulate instrumental actions to provide additional information for a coactor (Pezzulo, Donnarumma, & Dindo, 2013). Similarly, demonstrators adjust instrumental actions to make them more informative for novice learners (Brand, Baldwin, & Ashburn, 2002). It is unknown whether the kinematic modulations performed to facilitate prediction in joint action coordination and the modulations performed to transmit information about the structure of novel actions are unique, or whether a general type of modulation can take on multiple functions...
November 20, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/29153572/prognostic-value-of-quantitative-stress-perfusion-cardiac-magnetic-resonance
#10
Eva C Sammut, Adriana D M Villa, Gabriella Di Giovine, Luke Dancy, Filippo Bosio, Thomas Gibbs, Swarna Jeyabraba, Susanne Schwenke, Steven E Williams, Michael Marber, Khaled Alfakih, Tevfik F Ismail, Reza Razavi, Amedeo Chiribiri
OBJECTIVES: This study sought to evaluate the prognostic usefulness of visual and quantitative perfusion cardiac magnetic resonance (CMR) ischemic burden in an unselected group of patients and to assess the validity of consensus-based ischemic burden thresholds extrapolated from nuclear studies. BACKGROUND: There are limited data on the prognostic value of assessing myocardial ischemic burden by CMR, and there are none using quantitative perfusion analysis. METHODS: Patients with suspected coronary artery disease referred for adenosine-stress perfusion CMR were included (n = 395; 70% male; age 58 ± 13 years)...
November 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29153298/barriers-to-optimal-pain-management-in-aged-care-facilities-an-australian-qualitative-study
#11
Felicity Veal, Mackenzie Williams, Luke Bereznicki, Elizabeth Cummings, Angus Thompson, Gregory Peterson, Tania Winzenberg
Up to 80% of residents in aged care facilities (ACFs) experience pain, which is often suboptimally managed. To characterize pain management in ACFs and identify the barriers to optimal pain management. An exploratory descriptive qualitative study using semistructured interviews. Five Southern Tasmania, Australian ACFs. 23 staff members (18 nurses and 5 facility managers). Interviews were conducted from September to November 2015. Interviews included questions about how pain was measured or assessed, what happened if pain was identified, barriers to pain management, and potential ways to overcome these barriers...
November 15, 2017: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29150597/author-correction-two-magnon-scattering-in-the-5d-all-in-all-out-pyrochlore-magnet-cd2os2o7
#12
Thi Minh Hien Nguyen, Luke J Sandilands, C H Sohn, C H Kim, Aleksander L Wysocki, In-Sang Yang, S J Moon, Jae-Hyeon Ko, J Yamaura, Z Hiroi, Tae Won Noh
A correction to this article has been published and is linked from the HTML version of this article.
November 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29149371/imaging-patterns-of-venous-related-brain-injury-in-children
#13
Luke L Linscott, James L Leach, Blaise V Jones, Todd A Abruzzo
Venous-related brain injury is a common form of cerebrovascular injury in children and encompasses a diverse group of cerebrovascular diagnoses. The purpose of this pictorial essay is to introduce the relevant anatomy, pathophysiology and various imaging patterns of venous-related cerebral injury in children. Unifying concepts to better understand the effects of venous hypertension in the developing brain will be emphasized. These unifying concepts will provide the imaging professional with a conceptual framework to better understand and confidently identify imaging patterns of venous-related cerebral injury...
December 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29149334/reassessing-the-likely-harms-to-kidney-vendors-in-regulated-organ-markets
#14
Luke Semrau
Julian Koplin, drawing extensively on empirical data, has argued that vendors, even in well-regulated kidney markets, are likely to be significantly harmed. I contend that his reasoning to this conclusion is dangerously mistaken. I highlight two failures. First, Koplin is insufficiently attentive to the differences between existing markets and the regulated markets proposed by advocates. On the basis of this error, he wrongly concludes that many harms will persist even in a well-regulated system. Second, Koplin misunderstands the utilitarian assessment of the market...
November 15, 2017: Journal of Medicine and Philosophy
https://www.readbyqxmd.com/read/29149332/kidney-sales-and-market-regulation-a-reply-to-semrau
#15
Julian J Koplin
Luke Semrau argues that the documented harms of existing organ markets do not undermine the case for establishing regulated systems of paid kidney donation. He offers two arguments in support of this conclusion. First, Semrau argues that the harms of kidney selling are straightforwardly amenable to regulatory solution. Second, Semrau argues that even in existing black markets, sellers would likely have experienced greater harm if the option of selling a kidney were not available. This commentary challenges both of Semrau's claims...
November 15, 2017: Journal of Medicine and Philosophy
https://www.readbyqxmd.com/read/29149093/evolutionarily-distant-streptophyta-respond-differently-to-genotoxic-stress
#16
Radka Vágnerová, Alena Lukešová, Martin Lukeš, Petra Rožnovská, Marcela Holá, Jana Fulnečková, Jiří Fajkus, Karel J Angelis
Research in algae usually focuses on the description and characterization of morpho-and phenotype as a result of adaptation to a particular habitat and its conditions. To better understand the evolution of lineages we characterized responses of filamentous streptophyte green algae of the genera Klebsormidium and Zygnema, and of a land plant-the moss Physcomitrellapatens-to genotoxic stress that might be relevant to their environment. We studied the induction and repair of DNA double strand breaks (DSBs) elicited by the radiomimetic drug bleomycin, DNA single strand breaks (SSB) as consequence of base modification by the alkylation agent methyl methanesulfonate (MMS) and of ultra violet (UV)-induced photo-dimers, because the mode of action of these three genotoxic agents is well understood...
November 17, 2017: Genes
https://www.readbyqxmd.com/read/29147914/novice-chimpanzees-cooperate-successfully-in-the-presence-of-experts-but-may-have-limited-understanding-of-the-task
#17
Malini Suchak, Julia Watzek, Luke F Quarles, Frans B M de Waal
Despite many observations of cooperation in nature, laboratory studies often fail to find careful coordination between individuals who are solving a cooperative task. Further, individuals tested are often naïve to cooperative tasks and there has been little exploration of partnerships with mixed expertise. In the current study, we examined acquisition of a cooperative pulling task in a group with both expert (N = 4) and novice (N = 11) chimpanzees (Pan troglodytes). We used five measures of competence and understanding: (1) success at the task, (2) latency to succeed, (3) efficiency, (4) uncoordinated pulling, and (5) pulling when a partner was present versus absent...
November 17, 2017: Animal Cognition
https://www.readbyqxmd.com/read/29147848/simultaneous-point-of-care-detection-of-anemia-and-sickle-cell-disease-in-tanzania-the-rapid-study
#18
Luke R Smart, Emmanuela E Ambrose, Kevin C Raphael, Adolfine Hokororo, Erasmus Kamugisha, Erika A Tyburski, Wilbur A Lam, Russell E Ware, Patrick T McGann
Both anemia and sickle cell disease (SCD) are highly prevalent across sub-Saharan Africa, and limited resources exist to diagnose these conditions quickly and accurately. The development of simple, inexpensive, and accurate point-of-care (POC) assays represents an important advance for global hematology, one that could facilitate timely and life-saving medical interventions. In this prospective study, Robust Assays for Point-of-care Identification of Disease (RAPID), we simultaneously evaluated a POC immunoassay (Sickle SCAN™) to diagnose SCD and a first-generation POC color-based assay to detect anemia...
November 16, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29147538/scaling-behaviour-and-rate-determining-steps-in-filamentous-self-assembly
#19
Georg Meisl, Luke Rajah, Samuel A I Cohen, Manuela Pfammatter, Anđela Šarić, Erik Hellstrand, Alexander K Buell, Adriano Aguzzi, Sara Linse, Michele Vendruscolo, Christopher M Dobson, Tuomas P J Knowles
The formation of filaments from naturally occurring protein molecules is a process at the core of a range of functional and aberrant biological phenomena, such as the assembly of the cytoskeleton or the appearance of aggregates in Alzheimer's disease. The macroscopic behaviour associated with such processes is remarkably diverse, ranging from simple nucleated growth to highly cooperative processes with a well-defined lagtime. Thus, conventionally, different molecular mechanisms have been used to explain the self-assembly of different proteins...
October 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29146678/cross-organ-sensitisation-between-the-colon-and-bladder-to-pee-or-not-to-pee
#20
Luke Grundy, Stuart M Brierley
Chronic abdominal and pelvic pain are common, debilitating clinical conditions experienced by millions of patients around the globe. The origin of such pain commonly arises from the intestine and bladder, which share common primary roles; the collection, storage and expulsion of waste. These visceral organs are located in close proximity to one another, and also share common innervation from spinal afferent pathways. Chronic abdominal pain, constipation or diarrhoea are primary symptoms for patients with Irritable Bowel Syndrome (IBS) or Inflammatory Bowel Disease (IBD)...
November 16, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
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