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Functional dyspepsia

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https://www.readbyqxmd.com/read/28343377/protein-kinase-c-mediates-the-corticosterone-induced-sensitization-of-dorsal-root-ganglion-neurons-innervating-the-rat-stomach
#1
Meng Li, Lu Xue, Hong-Yan Zhu, Hongjun Wang, Xue Xu, Geping Wu, Guang-Yin Xu
Background/Aims: Gastric hypersensitivity contributes to abdominal pain in patients with functional dyspepsia (FD). Recent studies showed that hormones induced by stress are correlated with visceral hypersensitivity. However, the precise mechanisms underlying gastric hypersensitivity remain largely unknown. The aim of the present study was designed to investigate the roles of corticosterone (CORT) on excitability of dorsal root ganglion (DRG) neurons innervating the stomach. Methods: DRG neurons innervating the stomach were labeled by DiI injection into the stomach wall...
March 26, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28338267/disrupted-intrinsic-connectivity-of-the-periaqueductal-gray-in-patients-with-functional-dyspepsia-a-resting-state-fmri-study
#2
P Liu, G Wang, Y Liu, F Zeng, D Lin, X Yang, F Liang, V D Calhoun, W Qin
BACKGROUND: Functional dyspepsia (FD) is a common functional gastrointestinal disorder. Accumulating evidence suggests the crucial role of central nervous system in the development and maintenance of FD. In particular, periaqueductal gray (PAG) has demonstrated an important role in modulation of pain and emotion, which may be related to FD. However, the study of the PAG in FD is still limited. This study aimed to assess intrinsic connectivity of the PAG in FD patients. METHODS: Resting-state functional magnetic imaging (fMRI) data were collected from 66 FD patients and 42 healthy controls (HCs)...
March 24, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28326599/functional-dyspepsia-is-associated-with-duodenal-eosinophilia-in-an-australian-paediatric-cohort
#3
L Wauters, S Nightingale, N J Talley, B Sulaiman, M M Walker
BACKGROUND: The pathophysiology of functional dyspepsia (FD) remains unknown. Duodenal eosinophil infiltration has been reported. AIM: To assess the association between dyspeptic symptoms and duodenal eosinophilia in children undergoing upper gastrointestinal endoscopy. METHODS: In this retrospective cohort study, children with normal upper endoscopy and routine histology at a single tertiary paediatric centre between 2010 and 2014 were included...
March 21, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28317316/severely-impaired-gastric-accommodation-is-a-hallmark-of-post-nissen-functional-dyspepsia-symptoms
#4
A Pauwels, V Boecxstaens, C Broers, J F Tack
BACKGROUND: Laparoscopic Nissen fundoplication is a commonly performed antireflux surgery, after which reflux symptoms are well controlled, however, complications such as inability to belch or dyspeptic symptoms (mimicking those of functional dyspepsia [FD]) might occur. The aim of the study was to prospectively evaluate symptom pattern and underlying pathophysiological mechanisms in patients with post-Nissen dyspepsia. METHODS: Twenty-four patients (12 f, mean age 44...
March 20, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28295895/rome-iii-functional-dyspepsia-symptoms-classification-severity-vs-frequency
#5
F Carbone, L Holvoet, T Vanuytsel, J Tack
BACKGROUND: The Rome III criteria subdivide functional dyspepsia (FD) in the epigastric pain syndrome (EPS) and the postprandial distress syndrome (PDS) based on the frequency of the symptoms to optimize the diagnostic and therapeutic approach. However, it is unclear to which extent the frequency of the symptoms is related to their severity. Our aim was to explore the frequency and severity of dyspeptic symptoms and their relationship in FD patients. METHODS: Functional dyspepsia patients fulfilling the Rome III diagnostic completed a questionnaire that evaluated the frequency and severity of FD symptoms...
March 13, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28291238/polymorphisms-of-5-htt-lpr-and-gn%C3%AE-3-825c-t-and-response-to-antidepressant-treatment-in-functional-dyspepsia-a-study-from-the-functional-dyspepsia-treatment-trial
#6
Yuri A Saito, G Richard Locke, Ann E Almazar, Ernest P Bouras, Colin W Howden, Brian E Lacy, John K DiBaise, Charlene M Prather, Bincy P Abraham, Hashem B El-Serag, Paul Moayyedi, Linda M Herrick, Lawrence A Szarka, Michael Camilleri, Frank A Hamilton, Cathy D Schleck, Katherine E Tilkes, Alan R Zinsmeister, Nicholas J Talley
OBJECTIVES: The Functional Dyspepsia Treatment Trial reported that amitriptyline (AMI) was associated with adequate relief of functional dyspepsia (FD) symptoms, but the pharmacogenetics of antidepressant response in FD are not known. GNβ3 825C>T CC genotype has been previously linked to FD and TT genotype to antidepressant response in depression. The ss genotype of the 5-HTT LPR variant of the serotonin transporter gene (SLC6A4) has been linked to selective serotonin reuptake inhibitor (SSRI) response...
March 14, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28291006/assessment-of-the-prevalence-of-diabetic-gastroparesis-and-validation-of-gastric-emptying-scintigraphy-for-diagnosis
#7
Zeinab Alipour, Foad Khatib, Seyed Masoud Tabib, Hamid Javadi, Esmail Jafari, Leila Aghaghazvini, Ali Mahmoud-Pashazadeh, Iraj Nabipour, Majid Assadi
OBJECTIVE: Gastroparesis is defined as delayed gastric emptying and is a common medical condition in diabetic patients. Scintigraphy is commonly used as a standard diagnostic procedure for the quantitative assessment of gastroparesis. The aims of this study were to determine an optimum imaging time for the diagnosis of gastroparesis, to assess the prevalence of gastroparesis, to evaluate the correlation between endoscopy and scintigraphy findings as well as the correlation between gastric emptying with patient genders, blood glucose concentration, and functional dyspepsia...
February 5, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28281276/duodenal-mucosa-foxp3-expression-in-different-etiologies-of-lymphocytic-duodenosis
#8
Luis Vaquero, Laura Rodríguez-Martín, Mercedes Hernando, Marcos Jiménez, Luz Monteserín, Begoña Alvarez-Cuenllas, Jose M Ruiz de Morales, Sara Calleja, Santiago Vivas
BACKGROUND/AIMS: In celiac disease there is an increase of lymphocytes expressing FOXP3 in the intestinal mucosa associated with varying degrees of villous atrophy. Our aim was to evaluate FOXP3 expression in duodenal mucosa with lymphocytic enteritis according to aetiology and correlation with lymphocytes T-γδ. METHODS: We compared three adult patient groups suffering lymphocytic enteritis: celiacs following a gluten-free diet (n=12), first-degree relatives of celiac patients with genetic risks (n=14) and patients with functional dyspepsia (n=14), along with a control group not suffering from duodenal enteritis (n=16)...
March 10, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28277856/electrical-therapies-for-gastrointestinal-motility-disorders
#9
Jiande D Z Chen, Jieyun Yin, Wei Wei
Gastrointestinal (GI) motility disorders are common in clinical settings, including esophageal motility disorders, gastroesophageal reflux disease, functional dyspepsia, gastroparesis, chronic intestinal pseudo-obstruction, post-operative ileus, irritable bowel syndrome, diarrhea and constipation. While a number of drugs have been developed for treating GI motility disorders, few are currently available. Emerging electrical stimulation methods may provide new treatment options for these GI motility disorders...
March 21, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28272380/complexity-and-diversity-of-gerd-phenotypes
#10
Patrizia Zentilin, Elisa Marabotto, Gaia Pellegatta, Claudia Coppo, Manuele Furnari, Edoardo Savarino, Vincenzo Savarino
Gastroesophageal reflux disease (GERD) is defined as a condition which develops when the reflux of gastric contents causes troublesome symptoms, impairs quality of life, or leads to mucosal damage or complications. There are two main phenotypic presentations of GERD, the erosive (ERD) and non-erosive reflux disease (NERD), with the latter one representing up to 70% of GERD spectrum. Moreover, patients with GERD can be clinically subdivided into two distinct syndromes: patinets with esophageal and extraesophageal symptoms...
March 7, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28271513/proton-pump-inhibitors-for-functional-dyspepsia
#11
REVIEW
Maria Ines Pinto-Sanchez, Yuhong Yuan, Premysl Bercik, Paul Moayyedi
BACKGROUND: Functional dyspepsia (FD or non-ulcer dyspepsia) is defined as continuous or frequently recurring epigastric pain or discomfort for which no organic cause can be found. Acid suppressive therapy, including proton pump inhibitors (PPIs), has been proposed as a therapeutic option in FD, but its efficacy remains controversial. While PPIs are generally considered safe and well tolerated, they have been associated with adverse events, especially in the long term. For this reason, decisions on whether to initiate or continue PPI therapy should be made based on an appropriate clinical indication...
March 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28267193/nya-riktlinjer-f%C3%A3-r-handl%C3%A3-ggning-av-dyspepsi-h-pylori-och-mags%C3%A3-r
#12
Lars Agreus, Magnus Simrén
New Swedish guidelines for the management of dyspepsia, H pylori, and duodenal and gastric ulcers The management of dyspepsia in Sweden differs between national county councils, and is often not in line with international recommendations. The Swedish Society of Gastroenterology has together with the Swedish College of General Practice (SFAM) developed new national guidelines for the management of uninvestigated dyspepsia, functional dyspepsia, Helicobacter pylori, and uncomplicated duodenal and gastric ulcers...
February 28, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28264722/efficacy-and-safety-of-manual-acupuncture-manipulations-with-different-frequencies-on-epigastric-pain-syndrome-eps-in-functional-dyspepsia-fd-patients-study-protocol-for-a-randomized-controlled-trial
#13
Shou-Hai Hong, Sha-Sha Ding, Fei Wu, Ying Bi, Fu Xu, Yi-Jia Wan, Li-Hua Xuan
BACKGROUND: Manual acupuncture (MA) manipulations are one of the key factors influencing acupuncture effects in traditional Chinese medicine theory. Different MA manipulations contain different stimulating parameters, thus generating different acupuncture responses or effects. Evidence has demonstrated that acupuncture is effective for functional dyspepsia (FD). However, the effects of different stimulating parameters of MA manipulations on FD remain unclear. METHODS/DESIGN: This study is a randomized controlled trial with a four-arm, parallel-group structure...
March 6, 2017: Trials
https://www.readbyqxmd.com/read/28260354/overlap-of-gerd-and-gastrointestinal-functional-disorders
#14
Nicola De Bortoli, Veronica Natali, Sara Melissari, Natalia Simonetti, Gherardo Tapete, Santino Marchi
The functional gastrointestinal disorders (FGIDs) are common conditions with an overall prevalence burden estimated at approximately one-third of the population. These represent a heterogeneous group of conditions which may include both abnormal symptom perception and functional causes and seems to share similar trigger factors as food, lifestyle and psychological factor. GERD develops when the reflux of gastric contents into the esophagus leads to troublesome symptoms, with or without mucosal involvement. Functional heartburn represents a subcategory of patients who refers with heartburn but without abnormal esophageal acid exposure, abnormal number of reflux events or any temporal correlation between symptoms and reflux events, on the same hands these patients do not report any symptom relief during antisecretory treatment with proton pump inhibitors...
March 3, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28257540/water-load-test-in-children-with-chronic-abdominal-pain-or-obesity-compared-with-nonobese-controls
#15
Rami Arrouk, Aryn Karpinski, Teri Lavenbarg, John Belmont, Richard W McCallum, Paul Hyman
OBJECTIVE: Satiety is the perception of satisfied fullness and represents a summation of neural and hormonal influences. Satiety can be assessed by drink tests, including water load. The objective of our study was to confirm the difference in water load volume between nonobese control children and children with functional dyspepsia (FD), children with irritable bowel syndrome (IBS), and obese children. METHODS: A total of 158 children ages 6 to 13 years participated in the study...
March 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28244670/the-low-fodmap-diet-in-the-management-of-functional-dyspepsia-in-east-and-southeast-asia
#16
REVIEW
Victoria P Tan
Functional dyspepsia (FD) is a common disorder in East and Southeast Asia where subjects experience post prandial fullness/bloating, early satiety, belching, epigastric pain, and/or burning. A subset of patients with FD experience triggers exclusively related to meals, defined as the post prandial distress syndrome in the Rome IV guidelines. There is significant overlap of symptoms and implicated pathogenic factors with another common functional gastrointestinal disorder, irritable bowel syndrome (IBS) and in fact, a significant proportion of subjects have FD/IBS overlap...
March 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28233580/an-optimized-clarithromycin-free-14-day-triple-therapy-for-helicobacter-pylori-eradication-achieves-high-cure-rates-in-uruguay
#17
Cristina Dacoll, Jordi Sánchez-Delgado, Henia Balter, Ximena Pazos, María Di Pace, Gabriela Sandoya, Henry Cohen, Xavier Calvet
BACKGROUND: Strong acid inhibition increases cure rates with triple therapy and 14-day are more effective than 7-day treatments. The combination of amoxicillin plus metronidazole at full doses has been shown to overcome metronidazole resistance and to achieve good eradication rates even in patients harboring resistant strains. No previous studies have been reported in Latin-America with this optimized triple-therapy scheme. AIMS: The aim of the present study was to assess the eradication rate and tolerance of a new first-line treatment regimen associating strong acid inhibition, amoxicillin and metronidazole...
February 20, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28230610/16s-rdna-gene-sequencing-analysis-in-functional-dyspepsia-treated-with-fecal-microbiota-transplantation
#18
Jiayi Wang, Jianlei Gu, Yizhong Wang, Kai Lin, Shiyi Liu, Hui Lu, Ting Zhang, Guangjun Yu
No abstract text is available yet for this article.
March 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28226358/-laparoscopic-segmental-gastrectomy-for-early-gastric-cancer
#19
Lai Xu, Beizhan Niu, Xiyu Sun, Menghua Dai, Yi Xiao
OBJECTIVE: To investigate the feasibility of segmental pylorus-reservation gastrectomy in patients with early gastric cancer. METHOD: A retrospective cohort study on clinical data of 6 patients strictly met the criteria of early gastric cancer locating in the middle of the stomach undergoing laparoscopic segmental gastrectomy from January 2014 to April 2016 at Department of General Surgery, Peking Union Medical College Hospital was carried out. Preoperative clinical staging revealed T1N0M0 for all the cases...
February 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28223725/gut-microbial-diversity-analysis-using-illumina-sequencing-for-functional-dyspepsia-with-liver-depression-spleen-deficiency-syndrome-and-the-interventional-xiaoyaosan-in-a-rat-model
#20
Juan-Juan Qiu, Zhe Liu, Peng Zhao, Xue-Jun Wang, Yu-Chun Li, Hua Sui, Lawrence Owusu, Hui-Shu Guo, Zheng-Xu Cai
AIM: To investigate gut microbial diversity and the interventional effect of Xiaoyaosan (XYS) in a rat model of functional dyspepsia (FD) with liver depression-spleen deficiency syndrome. METHODS: The FD with liver depression-spleen deficiency syndrome rat model was established through classic chronic mild unpredictable stimulation every day. XYS group rats received XYS 1 h before the stimulation. The models were assessed by parameters including state of the rat, weight, sucrose test result and open-field test result...
February 7, 2017: World Journal of Gastroenterology: WJG
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