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Functional dyspepsia

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https://www.readbyqxmd.com/read/28913843/food-and-functional-dyspepsia-a-systematic-review
#1
REVIEW
K R Duncanson, N J Talley, M M Walker, T L Burrows
BACKGROUND: Functional dyspepsia (FD) is a debilitating functional gastrointestinal disorder characterised by early satiety, post-prandial fullness or epigastric pain related to meals, which affects up to 20% of western populations. A high dietary fat intake has been linked to FD and duodenal eosinophilia has been noted in FD. We hypothesised that an allergen such as wheat is a risk factor for FD and that withdrawal will improve symptoms of FD. We aimed to investigate the relationship between food and functional dyspepsia...
September 15, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28899670/definition-pathogenesis-and-management-of-that-cursed-dyspepsia
#2
REVIEW
Pramoda Koduru, Malcolm Irani, Eamonn M M Quigley
Dyspepsia is an umbrella term used to encompass a number of symptoms thought to originate from the upper gastrointestinal tract. These symptoms are relatively non-specific; not surprisingly, therefore, a myriad of conditions may present with any one or a combination of these symptoms. Therein lies the clinician's first challenge: detecting the minority who may have a potentially life-threatening disorder, such as gastric cancer, from a population whose symptoms are, for the most part, considered functional in origin...
September 9, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28894515/association-of-gastrointestinal-functional-disorders-and-migraine-headache-a-population-base-study
#3
Kamran B Lankarani, Maryam Akbari, Reza Tabrizi
BACKGROUND Migraine is one of the prevalent headaches. Many of patients with migraine, complain of gastrointestinal symptoms. There is limited studies on relation of gastrointestinal symptoms and migraine headache at population level. METHODS In this population-based study, 1038 subjects older than 15 year from a rural area in Fars province, south of Iran. were investigated for functional gastrointestinal disorders. By cluster random sampling, 160 of these persons invited to receive endoscopy along with histopathology samples of upper gastrointestinal tract...
July 2017: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28891136/helicobacter-pylori-infection-and-nonmalignant-diseases
#4
REVIEW
Olga Sjomina, Frederic Heluwaert, Driffa Moussata, Marcis Leja
A substantial decrease in Helicobacter pylori-associated peptic ulcer disease has been observed during the last decades. Drug-related ulcers as well as idiopathic ulcers are becoming predominant and are more refractory to treatment; however, H. pylori infection still plays an important role in ulcer bleeding and recurrence after therapy. The effect of H. pylori eradication upon functional dyspepsia symptoms has been reviewed in this article and generally confirms the results of previous meta-analyses. Additional evidence suggests a lack of impact upon the quality of life, in spite of improvement in symptoms...
September 2017: Helicobacter
https://www.readbyqxmd.com/read/28887755/prokinetics-in-the-management-of-functional-gastrointestinal-disorders
#5
REVIEW
Eamonn M M Quigley
PURPOSE OF REVIEW: The goal of this review is to review the current status of prokinetics and to place it in historical context. Impaired motility and thus propulsion have long been thought to play important roles in the pathogenesis of a number of gastrointestinal disorders including gastroesophageal reflux disease (GERD), gastroparesis, chronic idiopathic pseudo-obstruction, and constipation. Historically, disordered motility was also thought to contribute to a number of functional gastrointestinal disorders such as functional dyspepsia (FD) and irritable bowel syndrome (IBS)...
September 8, 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28884565/how-should-we-manage-patients-with-functional-dyspepsia-in-clinical-practice
#6
Edda Battaglia, Mario Grassini
No abstract text is available yet for this article.
September 7, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28883239/superior-mesenteric-artery-syndrome-may-be-overlooked-in-women-with-functional-dyspepsia
#7
Koki Kawanishi, Kensaku Shojima, Masayuki Nishimoto, Hiroko Abe, Tetsuhiro Kakimoto, Yuko Yasuda, Takeshi Hara, Jun Kato
Objective Superior mesenteric artery (SMA) syndrome is characterized by the compression of the third segment of the duodenum between the SMA and aorta, resulting in duodenal obstruction. Because the symptoms of the syndrome are similar to those of functional dyspepsia (FD), this study aimed to examine whether or not patients with SMA syndrome were present among those diagnosed with FD. Methods Patients with an FD diagnosis underwent measurement of the angle and distance between the SMA and aorta by ultrasonography or computed tomography...
September 6, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28875974/-functional-gastrointestinal-disorders-in-children-and-adolescents-the-rome-iv-criteria
#8
REVIEW
Barbara Iwańczak, Franciszek Iwańczak
In the work diagnostic criteria of functional disorders of the gastrointestinal tract in children and adolescents aged 4 to 18 years are presented. The criteria were elaborated by experienced experts in pediatrics and gastroenterology and were presented on Digestive Disease Week in San Diego in 2016 as modified IV Rome Criteria. In the work the following functional disorders are discussed: cyclic vomiting syndrome, functional nausea and vomiting, rumination syndrome, aerophagia, functional dyspepsia, irritable bowel syndrome, abdominal migraine, functional abdominal pain - not otherwise specified, functional constipation, nonretentive fecal incontinence...
August 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28874084/impaired-vagal-activity-to-meal-in-patients-with-functional-dyspepsia-and-delayed-gastric-emptying
#9
W-J Guo, S-K Yao, Y-L Zhang, S-Y Du, H-F Wang, L-J Yin, H-L Li
Objective This study was performed to investigate impaired vagal activity to meal in patients with functional dyspepsia (FD) with delayed gastric emptying (GE). Methods Eighty-five patients were studied. GE parameters, including those in the overall and proximal stomach, were measured by GE functional tests at the Department of Nuclear Medicine. Autonomic nervous function was tested by spectral analysis of heart rate variability (HRV). The vagal activity and sympathetic activity were analyzed by recording the power in the high-frequency component (HF), low-frequency component (LF), and LF/HF ratio...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28871092/acupuncture-and-related-therapies-used-as-add-on-or-alternative-to-prokinetics-for-functional-dyspepsia-overview-of-systematic-reviews-and-network-meta-analysis
#10
Robin S T Ho, Vincent C H Chung, Charlene H L Wong, Justin C Y Wu, Samuel Y S Wong, Irene X Y Wu
Prokinetics for functional dyspepsia (FD) have relatively higher number needed to treat values. Acupuncture and related therapies could be used as add-on or alternative. An overview of systematic reviews (SRs) and network meta-analyses (NMA) were performed to evaluate the comparative effectiveness of different acupuncture and related therapies. We conducted a comprehensive literature search for SRs of randomized controlled trials (RCTs) in eight international and Chinese databases. Data from eligible RCTs were extracted for random effect pairwise meta-analyses...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28865098/therapy-of-gerd-and-fd-overlap-with-symptoms-after-usual-dose-ppi-acotiamide-plus-usual-dose-ppi-vs-double-dose-ppi
#11
Toshihisa Takeuchi, Yoshiaki Takahashi, Shinpei Kawaguchi, Kazuhiro Ota, Satoshi Harada, Yuichi Kojima, Hiroki Sakamoto, Takanori Kuramoto, Keishi Kojima, Makoto Sanomura, Masahiro Hoshimoto, Takeshi Higashino, Tsukasa Itabashi, Ko Takada, Masahiro Sakaguchi, Kazunari Tominaga, Motoyasu Kusano, Kazuhide Higuchi
BACKGROUND AND AIM: Gastroesophageal reflux disease (GERD) and functional dyspepsia (FD) often coexist or overlap. In this study, the efficacy of acotiamide in combination with a standard dose of rabeprazole for GERD and FD was compared with that of a double dose of rabeprazole. METHODS: Patients with overlap between GERD and FD experiencing heartburn and epigastric fullness symptoms after standard-dose proton pump inhibitor (PPI) for ≥8 weeks were randomized into two groups, and received either acotiamide 300 mg/day + rabeprazole 10 mg/day or rabeprazole 20 mg/day for 4 weeks...
September 1, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28859216/evaluating-the-multitarget-effects-of-combinations-through-multistep-clustering-of-pharmacological-data-the-example-of-the-commercial-preparation-iberogast
#12
Heba Abdel-Aziz, Olaf Kelber, Gerhard Lorkowski, Martin Storr
Herbal combination preparations are widely used in traditional herbal medicine and are even established as modern evidence-based herbal medicinal products. The rationale behind such combinations is often questioned and assessing the contribution of each of the combination partners to overall activity is challenging. STW 5 (Iberogast) is such a combination with confirmed clinical efficacy in functional gastrointestinal disorders. It consists of nine plant extracts responsible for its multitarget function in these multifactorial diseases with their heterogeneous and overlapping pathomechanisms...
August 31, 2017: Planta Medica
https://www.readbyqxmd.com/read/28854971/sini-san-improves-duodenal-tight-junction-integrity-in-a-rat-model-of-functional-dyspepsia
#13
Xiongfei Chang, Luqing Zhao, Jiajia Wang, Xiaofang Lu, Shengsheng Zhang
BACKGROUND: Recent reports have demonstrated that impaired barrier function and local microinflammation in the duodenal mucosa contribute to the pathogeneses of functional dyspepsia (FD). Thus, restoring normal barrier integrity becomes a potential therapeutic strategy in the treatment of FD. Sini-San (SNS) is a traditional Chinese prescription that exhibits therapeutic effects in FD, but the underlying mechanisms remain not well understood. METHODS: FD rats were established by tail clamping method and the therapeutic effect of SNS was evaluated by measuring the visceral sensitivity and gastric compliance...
August 30, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28852318/efficacy-and-safety-of-xiangsha-liujunzi-granules-for-functional-dyspepsia-a-multi-center-randomized-double-blind-placebo-controlled-clinical-study
#14
Lin Lv, Feng-Yun Wang, Xiang-Xue Ma, Zhen-Hua Li, Sui-Ping Huang, Zhao-Hong Shi, Hai-Jie Ji, Li-Qun Bian, Bei-Hua Zhang, Ting Chen, Xiao-Lan Yin, Xu-Dong Tang
AIM: To assess the efficacy and safety of a Chinese herbal medicine (CHM), Xiangsha Liujunzi granules, in the treatment of patients with functional dyspepsia (FD). METHODS: We performed a randomized, double-blind, placebo-controlled trial with patients from three centers. Two hundred and sixteen subjects diagnosed with FD according to ROME III criteria and confirmed by upper gastrointestinal endoscopy and spleen-deficiency and Qi-stagnation syndrome were selected to receive Xiangsha Liujunzi granules or placebo for 4 wk in a 2:1 ratio by blocked randomization...
August 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28832359/functional-dyspepsia-and-gastroparesis
#15
Jan Tack, Florencia Carbone
PURPOSE OF REVIEW: This review summarizes recent progress in the epidemiology, pathophysiology and treatment of functional dyspepsia and gastroparesis. RECENT FINDINGS: The definition of functional dyspepsia and its subgroups has been revised in the recent Rome IV consensus. In gastroparesis, the symptom pattern and its similarities and differences from functional dyspepsia have been a focus of recent research. In functional dyspepsia, pathophysiological research continued to evaluate gastric sensorimotor dysfunctions, but low-grade inflammatory changes and loss of mucosal integrity in the duodenum is a new topic of intense research...
August 21, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28818267/is-small-intestinal-bacterial-overgrowth-involved-in-the-pathogenesis-of-functional-dyspepsia
#16
Georgios Tziatzios, Evangelos J Giamarellos-Bourboulis, Ioannis S Papanikolaou, Mark Pimentel, George D Dimitriadis, Konstantinos Triantafyllou
Functional dyspepsia is a highly prevalent disease, with significant impacts on patients' quality of life and economic robustness of health care systems worldwide. It constitutes a constellation of symptoms located in the gastro duodenal region while its pathogenesis remains poorly understood. Accumulating evidence suggest that small intestinal bacterial overgrowth is associated with the etiology of functional gastrointestinal disorders. We herein present the hypothesis that a causal link between small intestinal bacterial overgrowth and functional dyspepsia might exist...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28814387/effects-of-nk1-receptors-on-gastric-motor-functions-and-satiation-in-healthy-humans-results-from-a-controlled-trial-with-the-nk1-antagonist-aprepitant
#17
Deepti Jacob, Irene A Busciglio, Duane D Burton, Houssam Halawi, Ibironke Oduyebo, Deborah Rhoten, Michael Ryks, W Scott Harmsen, Michael Camilleri
Aprepitant, an NK1 receptor antagonist, is approved for the treatment of chemotherapy-induced or postoperative emesis by blocking NK1 receptors in the brain stem vomiting center. Effects of NK1 receptors on gastric functions and postprandial symptoms in humans are unclear; a single, crossover study did not show a significant effect of aprepitant on gastrointestinal transit. Our aim was to compare, in a randomized, double-blind, placebo-controlled, parallel-group study (12 healthy volunteers per group), effects of aprepitant vs...
August 16, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28814319/constipation-in-adults-with-neurofibromatosis-type-1
#18
Cecilie Ejerskov, Klaus Krogh, John R Ostergaard, Janne L Fassov, Annette Haagerup
BACKGROUND: Neurofibromatosis type 1 (NF1) is an autosomal-dominant disease characterised by symptoms of the skin, eyes, nervous system and bones. A previous study indicated that constipation, large rectal diameters and prolonged colorectal transit times are common in children with NF1. The aim of the present study was to investigate and compare the prevalence of gastrointestinal symptoms in adult patients with NF1 to their unaffected relatives serving as the control group. Patients with NF1 were recruited from one of two Danish National Centres of Expertise for NF1 and their unaffected relatives were invited to participate as controls...
August 16, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28811716/development-and-validation-of-a-simple-and-multifaceted-instrument-gerd-test-for-the-clinical-evaluation-of-gastroesophageal-reflux-and-dyspeptic-symptoms
#19
Koji Nakada, Nobuyuki Matsuhashi, Katsuhiko Iwakiri, Atsushi Oshio, Takashi Joh, Kazuhide Higuchi, Ken Haruma
AIM: To evaluate the psychometric properties of a newly developed questionnaire, known as the gastroesophageal reflux and dyspepsia therapeutic efficacy and satisfaction test (GERD-TEST), in patients with GERD. METHODS: Japanese patients with predominant GERD symptoms recruited according to the Montreal definition were treated for 4 wk using a standard dose of proton pump inhibitor (PPI). The GERD-TEST and the Medical Outcome Study Short Form-8 Health Survey (SF-8) were administered at baseline and after 4 wk of treatment...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28809820/certain-dietary-habits-contribute-to-the-functional-dyspepsia-in-south-china-rural-area
#20
Ji-Hao Xu, Yu Lai, Li-Ping Zhuang, Can-Ze Huang, Chu-Qiang Li, Qi-Kui Chen, Tao Yu
BACKGROUND Functional dyspepsia (FD) refers to a group of upper gastrointestinal syndromes, subdivided into two types: postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS). The etiology of FD remains unclear; however, unhealthy dietary habit is one potential underlying cause. We aim to explore the association of poor dietary habits with FD and its subtypes. MATERIAL AND METHODS A validated epidemiological questionnaire was designed to investigate dietary habits and gastrointestinal syndromes...
August 15, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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