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Functional dyspepsia

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https://www.readbyqxmd.com/read/29347978/uninvestigated-dyspepsia-and-associated-factors-of-patients-with-gastrointestinal-disorders-in-dessie-referral-hospital-northeast-ethiopia
#1
Abdurahaman Seid, Zemenu Tamir, Wondmagegn Demsiss
BACKGROUND: Dyspepsia is a common problem in the community and clinical practice with symptom(s) considered arising from the gastroduodenal region. Dyspepsia burden and associated factors vary from country to country. The aim of this study was to determine the prevalence of uninvestigated dyspepsia (UD) using Rome III criteria, associated risk factors and self-reported dyspepsia symptoms' correlation with H. pylori infection. METHODS: A cross-sectional study was conducted among randomly selected 318 out patients with gastrointestinal complaints during the period from September 1 to December 30, 2015...
January 18, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29344328/management-of-functional-dyspepsia-state-of-the-art-and-emerging-therapies
#2
REVIEW
Hiroshi Yamawaki, Seiji Futagami, Mako Wakabayashi, Noriko Sakasegawa, Shuhei Agawa, Kazutoshi Higuchi, Yasuhiro Kodaka, Katsuhiko Iwakiri
Patients with functional dyspepsia, defined in the 2016 Rome IV criteria as bothersome clinical dyspepsia symptoms, experience markedly reduced quality of life. Several etiologies have been associated with the disorder. In the Rome IV criteria, the brain-gut axis was acknowledged as an important factor in the etiology of functional gastrointestinal (GI) disorders. The distinct subgroups of functional dyspepsia, epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS), are treated differently: acid secretion inhibitors are recommended with patients with EPS, whereas prokinetic drugs as mosapride and acotiamide are recommended for patients with PDS...
January 2018: Therapeutic Advances in Chronic Disease
https://www.readbyqxmd.com/read/29339955/highlights-in-functional-dyspepsia-treatment-from-digestive-disease-week-2017-may-6-9-2017-%C3%A2-chicago-illinois
#3
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29315999/long-term-safety-and-efficacy-of-acotiamide-in-functional-dyspepsia-postprandial-distress-syndrome-results-from-the-european-phase-3-open-label-safety-trial
#4
J Tack, J Pokrotnieks, G Urbonas, C Banciu, V Yakusevich, I Bunganic, H Törnblom, Y Kleban, P Eavis, M Tsuchikawa, T Miyagawa
BACKGROUNDS: Acotiamide is a novel acetylcholinesterase inhibitor for treatment of postprandial distress syndrome (PDS) symptoms of functional dyspepsia (FD). This European phase 3 open-label safety trial has been conducted to evaluate the long-term safety of acotiamide and explore the efficacy of acotiamide on PDS symptoms using the validated LPDS, quality of life using SF-36 and SF-NDI, and work productivity using WPAI. METHODS: FD-PDS patients (defined by ROME III criteria) aged ≥18 years with active PDS symptoms and without predominant overlapping symptoms of epigastric pain syndrome and related disorders were enrolled to receive 100 mg acotiamide three times daily for 1 year...
January 8, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29313700/a-question-about-dyspeptic-patients-analyzed-using-psychometric-scores
#5
Rinaldo Pellicano, Marilena Durazzo
Orive et al. reported the results of a randomized study that included patients with functional dyspepsia (FD) treated with standard versus standard plus a psychological approach. Reliability (Cronbach's alpha), validity (confirmatory factor analysis [FA]) and responsiveness were analyzed using specific questionnaires.
January 9, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29303047/eltrombopag-in-the-management-of-aplastic-anaemia-real-world-experience-in-a-non-trial-setting
#6
Yu-Yan Hwang, Harinder Gill, Thomas S Y Chan, Garret M K Leung, Carol Y M Cheung, Yok-Lam Kwong
OBJECTIVE: The thrombopoietin mimetic eltrombopag has been used in clinical trials for the frontline and salvage treatment of aplastic anaemia (AA). Eltrombopag was investigated in AA patients on a non-trial all-comer basis. METHODS: Consecutive newly diagnosed and relapsed/refractory AA patients were treated with eltrombopag. RESULTS: In a 4.5-year period, 20 consecutive AA patients (newly diagnosed, N = 10; relapsed/refractory, N = 10) at a median age of 47 (22-84) years were treated with eltrombopag...
January 5, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29299438/effect-of-apium-graveolens-and-trachyspermum-copticom-on-clinical-symptoms-of-patients-with-functional-dyspepsia
#7
Maryam Azimi, Mohammad Javad Zahedi, Mitra Mehrabani, Haleh Tajadini, Farzaneh Zolala, Mohammad Reza Baneshi, Rasool Choopani, Fariba Sharififar, Ali Asadipour, Mohammad Mahdi Hayatbakhsh, Bijan Ahmadi
Objectives: This study aimed at investigating the effect of Iranian traditional remedy prepared from Apium graveolens and Trachyspermum copticom (AT) on the severity and frequency of symptoms in patients with functional dyspepsia (FD). Material and Methods: In total, 150 FD patients were included in this randomized double-blind trial, based on the ROME III diagnostic criteria, and they were divided into three intervention groups namely, AT, Placebo and omeprazole...
November 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29296572/feasibility-study-of-structured-diagnosis-methods-for-functional-dyspepsia-in-korean-medicine-clinics
#8
Jeong Hwan Park, Soyoung Kim, Jae-Woo Park, Seok-Jae Ko, Sanghun Lee
Background: Functional dyspepsia (FD) is the seventh most common disease encountered in Korean medicine (KM) clinics. Despite the large number of FD patients visiting KM clinics, the accumulated medical records have no utility in evidence development, due to being unstructured. This study aimed to construct a standard operating procedure (SOP) with appropriate structured diagnostic methods for FD, and assess the feasibility for use in KM clinics. Methods: Two rounds of professional surveys were conducted by 10 Korean internal medicine professors to select the representative diagnostic methods...
December 2017: Integrative medicine research
https://www.readbyqxmd.com/read/29284270/measuring-health-related-quality-of-life-hrqol-in-functional-dyspepsia-is-it-really-important
#9
Belén Herreros Martínez, Pedro Almela Notari, Cirilo Amorós García
Concern for measuring health outcomes in real life and from the patient's perspective has been for years included in the management o many and various diseases, regardless of the presence or absence of a known organic basis and/or objective markers associated with their course or response to treatments. This approach partly results from patient inclusion in decisions involving their health, and also from the health definition put forward by the World Health Organization (WHO) as a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity...
December 28, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29282046/evaluation-of-pharmacodynamic-properties-and-safety-of-cinnamomum-zeylanicum-ceylon-cinnamon-in-healthy-adults-a-phase-i-clinical-trial
#10
Priyanga Ranasinghe, Ranil Jayawardena, Shehani Pigera, Wasundara Sevwandi Wathurapatha, Hasitha Dhananjaya Weeratunga, G A Sirimal Premakumara, Prasad Katulanda, Godwin Roger Constantine, Priyadarshani Galappaththy
BACKGROUND: Cinnamon is considered as a treatment for many ailments in native medicine. Evidence suggests that Cinnamomum zeylanicum (CZ) has anti-microbial, anti-parasitic, anti-oxidant, blood glucose lowering properties and beneficial cardiovascular effects. The present study aims to evaluate Pharmacodynamic properties and safety of CZ in healthy adults using a Phase I Clinical Trial. METHODS: This phase I clinical trial was conducted at the Department of Pharmacology, Faculty of Medicine, University of Colombo, Sri Lanka...
December 28, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29277088/-belching
#11
REVIEW
Yu Kyung Cho
Supragastric belching is the most important factor in the etiology of excessive belching complaints. Supragastric belching is a belching disorder with a behavioral origin. The standard diagnosis is made by monitoring the esophageal impedance. Supragastric belching has been shown to be associated with globus, as well as reflux symptoms in proton pump inhibitor non-responders in gastroesophageal reflux disease; however, the pathophysiology of supragastric belching in patients with gastroesophageal reflux disease or functional dyspepsia has not been clarified...
December 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29274173/investigation-of-autophagy-and-differentiation-of-myenteric-interstitial-cells-of-cajal-in-the-pathogenesis-of-gastric-motility-disorders-in-rats-with-functional-dyspepsia
#12
Li-Min Zhang, Li-Jun Zeng, Jing Deng, Yu-Qin Zhang, Yu-Jiao Wang, Tian-Yi Xie, Jiang-Hong Ling
BACKGROUND: Interstitial cells of Cajal (ICC), especially myenteric interstitial cells of Cajal (ICC-MY), are key to gastrointestinal motility. However, their role in the pathogenesis of functional dyspepsia (FD) is unclear. Therefore, autophagy and differentiation of ICC-MY were investigated to elucidate the pathogenesis of gastric motility disorder in FD. METHODS: FD model was induced by chronic stress via tail clamping in rats, which was assessed by the vital signs of rats, gastric emptying rate result and histology...
December 23, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/29259381/gender-differences-in-ghrelin-nociception-genes-psychological-factors-and-quality-of-life-in-functional-dyspepsia
#13
Yoon Jin Choi, Young Soo Park, Nayoung Kim, Yong Sung Kim, Sun Min Lee, Dong Ho Lee, Hyun Chae Jung
AIM: to evaluate gender differences in the aspect of ghrelin, nociception-related genes and psychological aspects and the quality of life (QoL) in Korean functional dyspepsia (FD) patients. METHODS: Total of 191 persons were prospectively enrolled between March 2013 and May 2016 in Seoul National Bundang Hospital, and classified into control and FD group based on ROME III criteria. Questionnaire included assessment for dyspepsia symptoms, QoL and anxiety or depression...
December 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29251169/prevalence-of-functional-gastrointestinal-disorders-in-adults-with-systemic-lupus-erythematosus
#14
M García-Carrasco, C Mendoza-Pinto, M A Autrán-Limón, E Herrera Robles, S Méndez Martínez, I Etchegaray Morales, Á Montiel Jarquín, J L Gálvez Romero, P Soto-Santillán, J Galindo-Herrera, A López-Colombo
Objective (a) to assess the prevalence of functional gastrointestinal disorders (FGIDs) in female Mexican systemic lupus erythematosus (SLE) patients using the Rome III criteria and (b) to examine the effect of disease duration on FGID prevalence. Methods Female SLE outpatients aged ≥18 years with no organic gastrointestinal disorder were included. Participants were invited to upper gastrointestinal endoscopy screening and a faecal immunochemical test. FGID symptoms were evaluated using the Rome III questionnaire...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/29240009/gastrointestinal-symptoms-in-children-and-adolescents-with-neurofibromatosis-type-1
#15
Cecilie Ejerskov, Klaus Krogh, John R Ostergaard, Iben Joensson, Annette Haagerup
OBJECTIVES: Neurofibromatosis type 1 (NF1) is a complex genetic disorder characterized by symptoms of the skin and nervous system. A previous study indicated that constipation is common in children with NF1. The aim of the present study was to investigate the phenotype and prevalence of gastrointestinal symptoms in a population of 4-17-year-olds with NF1 compared to their unaffected siblings. METHODS: Gastrointestinal symptoms were assessed with a web-based, parent or self-administered, validated, Rome® III diagnostic questionnaire...
December 12, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29234392/1h-nmr-based-metabonomic-study-of-functional-dyspepsia-in-stressed-rats-treated-with-chinese-medicine-weikangning
#16
Yu Guo, Zhongfeng Li, Xinfeng Liu, Xiaolan Su, Yijie Li, Jiajie Zhu, Yilin Song, Ping Zhang, Jiande D Z Chen, Ruhan Wei, Jianqin Yang, Wei Wei
1H NMR-based metabolic profiling combined with multivariate data analysis was used to explore the metabolic phenotype of functional dyspepsia (FD) in stressed rats and evaluate the intervention effects of the Chinese medicine Weikangning (WKN). After a 7-day period of model establishment, a 14-day drug administration schedule was conducted in a WKN-treated group of rats, with the model and normal control groups serving as negative controls. Based on 1H NMR spectra of urine and serum from rats, PCA, PLS-DA, and OPLS-DA were performed to identify changing metabolic profiles...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29218061/a-comparative-study-of-efficacy-and-safety-of-two-eradication-regimens-for-helicobacter-pylori-infection
#17
Carmen Monica Preda, Doina Proca, Irina Sandra, Larisa Elena Fulger, Boroka Claudia Horeanga, Mircea Manuc, Teodora Manuc, Catalin Andrei Dutei, Mihaela Barbu, Letitia Tugui, Adriana-Corina Andrei, Bogdan Ionut Slavulete, Mircea Diculescu
Introduction: Helicobacter pylori infection is one of the most frequent diseases around the world, affecting about half of the world population. The infection is known to be associated with upper gastrointestinal diseases. The aim of this paper is to identify which of the following two first-line therapy options (ECA vs ECM - see abbreviations below) is more efficient and to assess the improvement in the quality of life among these patients. Material and Methods: 96 patients with proven Helicobacter pylori infection were divided in two treatment groups, as follows: 47 patients received a 10-day triple therapy with esomeprazole 80 mg/day, amoxicillin 2000 mg/day and clarithromycin 1000 mg/day (ECA) and the rest of 49 received a 10-day sequential therapy: esomeprazole 40 mg and amoxicillin 1000 mg twice daily for five days, followed by esomeprazole 40 mg, clarithromycin 500 mg and metronidazole 500 mg (ECM) twice daily for another five days...
September 2017: Mædica
https://www.readbyqxmd.com/read/29213280/subthreshold-psychiatric-psychopathology-in-functional-gastrointestinal-disorders-can-it-be-the-bridge-between-gastroenterology-and-psychiatry
#18
Cristina Stasi, Cristiana Nisita, Sonia Cortopassi, Giorgio Corretti, Dario Gambaccini, Nicola De Bortoli, Bernardo Fani, Natalia Simonetti, Angelo Ricchiuti, Liliana Dell'Osso, Santino Marchi, Massimo Bellini
Background and Aims: Functional gastrointestinal disorders (FGDs) are multifactorial disorders of the gut-brain interaction. This study investigated the prevalence of Axis I and spectrum disorders in patients with FGD and established the link between FGDs and psychopathological dimensions. Methods: A total of 135 consecutive patients with FGD were enrolled. The symptoms' severity was evaluated using questionnaires, while the psychiatric evaluation by clinical interviews established the presence/absence of mental (Diagnostic and Statistical Manual-4th edition, Axis I Diagnosis) or spectrum disorders...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29204059/potential-rat-model-of-anxiety-like-gastric-hypersensitivity-induced-by-sequential-stress
#19
Fu-Chun Jing, Jun Zhang, Chen Feng, Yuan-Yuan Nian, Jin-Hai Wang, Hao Hu, Bao-De Yang, Xiao-Ming Sun, Jian-Yun Zheng, Xiao-Ran Yin
AIM: To establish a rat model of anxiety-like gastric hypersensitivity (GHS) of functional dyspepsia (FD) induced by novel sequential stress. METHODS: Animal pups were divided into two groups from postnatal day 2: controls and the sequential-stress-treated. The sequential-stress-treated group received maternal separation and acute gastric irritation early in life and restraint stress in adulthood; controls were reared undisturbed with their mothers. Rats in both groups were followed to adulthood (8 wk) at which point the anxiety-like behaviors and visceromotor responses to gastric distention (20-100 mmHg) and gastric emptying were tested...
November 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29199141/effects-of-amitriptyline-and-escitalopram-on-sleep-and-mood-in-patients-with-functional-dyspepsia
#20
Linda M Herrick, Michael Camilleri, Cathy D Schleck, Alan R Zinsmeister, Yuri A Saito, Nicholas J Talley
BACKGROUND & AIMS: Tricyclic antidepressants are effective in reducing symptoms of functional dyspepsia (FD). We performed a post hoc analysis of data from a previous randomized clinical trial to determine whether the benefits of an antidepressant on gastrointestinal symptoms in patients with FD were mediated by improving sleep or reducing anxiety. We explored the relationships between psychological measures, quality of sleep, and relief of symptoms. METHODS: We analyzed data from a multicenter, double-blind trial that evaluated the efficacy of antidepressants on symptoms of FD, from October 2006 through October 2012...
December 1, 2017: Clinical Gastroenterology and Hepatology
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