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Functional dyspepsia

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https://www.readbyqxmd.com/read/28728310/the-effect-of-h2-receptor-antagonist-in-acid-inhibition-and-its-clinical-efficacy
#1
REVIEW
Young Kwang Shim, Nayoung Kim
The first histamine H2 receptor antagonists (H2RAs) were developed in the early 1970s. They played a dominant role in treating peptic ulcer disease and gastroesophageal reflux disease (GERD). H2RAs block the production of acid by H(+), K(+)-ATPase at the parietal cells and produce gastric luminal anacidity for varying periods. H2RAs are highly selective, and they do not affect H1 receptors. Moreover, they are not anticholinergic agents. Sequential development of H2RAs, proton pump inhibitors (PPIs), and discovery of Helicobacter pylori infection changed the paradigm of peptic ulcer disease with marked decrease of morbidity and mortality...
July 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28725303/evaluation-of-esophageal-functions-by-manometry-in-iron-deficiency-anemia-patients
#2
Pinar Kubilay, Beyza Doganay, Mehmet Bektas
BACKGROUND: The aim of this study was to investigate whether any esophageal motor dysfunction exists in patients with iron deficiency anemia (IDA). METHODS: The study included 39 patients (34 women, mean age: 44.17 ± 14.21 years) who met WHO diagnostic criteria for IDA. An additional 30 functional dyspepsia patients were also included as a control group. Esophageal motility testing was performed; esophagus contraction amplitude, peak velocity, contraction time, lower esophageal sphincter (LES) resting pressure, LES relaxation, and LES relaxation duration were assessed...
June 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28709452/influence-of-the-patient-practitioner-interaction-context-on-acupuncture-outcomes-in-functional-dyspepsia-study-protocol-for-a-multicenter-randomized-controlled-trial
#3
Seok-Jae Ko, Jae-Woo Park, Jungtae Leem, Ted J Kaptchuk, Vitaly Napadow, Braden Kuo, Jessica Gerber, Laurie Dimisko, Inkwon Yeo, Junhee Lee, Jinsung Kim
BACKGROUND: In the treatment of functional dyspepsia, the placebo effect has been reported to be high, and the influence of the patient-practitioner relationship may be a major component of this effect. The specific and non-specific effects of acupuncture cannot be easily distinguished, and the patient-practitioner relationship may influence the total therapeutic effect in clinical practice. There have been no studies that investigate the influence of patient-practitioner relationship on acupuncture treatment for patients with functional dyspepsia...
July 14, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28707862/gastric-emptying-and-related-symptoms-in-patients-treated-with-buspirone-amitriptyline-or-clebopride-a-real-world-study-by-13c-octanoic-acid-breath-test
#4
Gian P Caviglia, Carlo Sguazzini, Fabio Cisaro', Davide G Ribaldone, Chiara Rosso, Sharmila Fagoonee, Antonina Smedile, Giorgio M Saracco, Marco Astegiano, Rinaldo Pellicano
BACKGROUND: Gastric motility is a key-factor in the pathogenesis of functional dyspepsia (FD). 13C-octanoic acid breath test (OBT) is a tool used for measuring gastric emptying time in clinicalsetting. We aimed to investigate the variation in FD symptoms and OBT parameters after treatment with buspirone, amitriptyline or clebopride. METHODS: Between Jan-2007 and Dec-2014, we enrolled 59 patients with FD unresponsive to firstling therapy with proton pump inhibitors and/or domperidone that underwent OBT before and after 3 months of buspirone (n=32), amitriptyline (n=16) or clebopride (n=11) treatment...
July 12, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28695660/a-randomized-placebo-controlled-trial-on-the-effects-of-menthacarin-a-proprietary-peppermint-and-caraway-oil-preparation-on-symptoms-and-quality-of-life-in-patients-with-functional-dyspepsia
#5
G Rich, A Shah, N Koloski, P Funk, B Stracke, S Köhler, G Holtmann
BACKGROUND: Functional dyspepsia (FD) is a very common condition affecting more than 10% of the population. While there is no cure, a few drugs have been found to be effective for the relief of symptoms, although most are only effective in a subgroup of patients. We assess and compare the efficacy of a fixed peppermint/caraway-oil-combination (Menthacarin) on symptoms and quality of life (QoL) in patients with FD symptoms consistent with epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS)...
July 10, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28695632/the-effect-of-mirtazapine-on-gastric-accommodation-gastric-sensitivity-to-distention-and-nutrient-tolerance-in-healthy-subjects
#6
F Carbone, T Vanuytsel, J Tack
BACKGROUND: Disturbances of gastric motor function of functional dyspepsia (FD) have been implicated in the pathogenesis of the symptoms, and hence, motility modifying agents are considered for its treatment. Mirtazapine was recently shown to improve symptoms and increase nutrient tolerance in FD patients with weight loss. We aim to evaluate the effect of mirtazapine on gastric sensorimotor function in healthy volunteers (HV). METHODS: Thirty-one HV underwent an intragastric pressure (IGP) and barostat measurements on separate days before and after 3 weeks of placebo or mirtazapine (15 mg)...
July 11, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28687943/symptoms-of-functional-intestinal-disorders-are-common-in-patients-with-celiac-disease-following-transition-to-a-gluten-free-diet
#7
Jocelyn A Silvester, Lesley A Graff, Lisa Rigaux, Charles N Bernstein, Daniel A Leffler, Ciarán P Kelly, John R Walker, Donald R Duerksen
BACKGROUND: Celiac disease and functional intestinal disorders may overlap, yet the natural history of functional symptoms in patients with celiac disease is unknown. AIM: To investigate the prevalence of irritable bowel syndrome (IBS), functional dyspepsia (FD), and functional bloating (FB) symptoms among patients with celiac disease at diagnosis and during the first year of a gluten-free diet. METHODS: Adults with a new diagnosis of celiac disease were surveyed at baseline, 6 months and 1 year using standardized measures for intestinal symptoms [Rome III diagnostic questionnaire and celiac symptom index (CSI)] and gluten-free diet adherence [gluten-free eating assessment tool (GF-EAT) and celiac diet adherence test]...
July 7, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28682047/upper-gastrointestinal-conditions-nonmalignant-conditions-of-the-stomach
#8
Ku-Lang Chang, David S Estores
Functional dyspepsia can be categorized into two syndromes: postprandial distress syndrome and epigastric pain syndrome. Helicobacter pyloriinfection is one of the most common chronic infections worldwide. Acute H pylori infection causes dyspepsia, and chronic infection can cause peptic ulcer disease. H pylori also is one of the causative agents in gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. The incidence of H pylori infection varies among different ethnic populations and geographic locations...
July 2017: FP Essentials
https://www.readbyqxmd.com/read/28674349/postprandial-symptoms-felt-at-the-lower-part-of-the-epigastrium-and-a-possible-association-of-pancreatic-exocrine-dysfunction-with-the-pathogenesis-of-functional-dyspepsia
#9
Yoshiko Fujikawa, Kazunari Tominaga, Fumio Tanaka, Noriko Kamata, Hirokazu Yamagami, Tetsuya Tanigawa, Toshio Watanabe, Yasuhiro Fujiwara, Tetsuo Arakawa
Objective In symptom-dependent diseases such as functional dyspepsia (FD), matching the pattern of epigastric symptoms, including severity, kind, and perception site, between patients and physicians is critical. Additionally, a comprehensive examination of the stomach, duodenum, and pancreas is important for evaluating the origin of such symptoms. Methods FD-specific symptoms (epigastric pain, epigastric burning, early satiety, and postprandial fullness) and other symptoms (regurgitation, nausea, belching, and abdominal bloating) as well as the perception site of the above symptoms were investigated in healthy subjects using a new questionnaire with an illustration of the human body...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28672431/the-application-of-the-rome-iv-criteria-to-functional-esophagogastroduodenal-disorders-in-asia
#10
REVIEW
Hidekazu Suzuki
The Rome criteria were amended as Rome IV. For functional esophageal disorders, the exclusion criteria have been more specifically revised based on further understanding of other esophageal disorders, including eosinophilic esophagitis and spastic and hypercontractile motor disorders. Another revised point is the more restrictive definition of gastroesophageal reflux disease, indicating that sensitivity to a physiological reflux burden may be placed more firmly within the functional group. For functional dyspepsia (FD), only minor changes were introduced, mainly to improve specificity...
July 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28672430/the-implication-of-gastric-dysmotility-in-the-pathophysiology-of-functional-dyspepsia
#11
EDITORIAL
Yang Won Min
No abstract text is available yet for this article.
July 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28657216/additive-effect-of-rikkunshito-an-herbal-medicine-on-chemotherapy-induced-nausea-vomiting-and-anorexia-in-uterine-cervical-or-corpus-cancer-patients-treated-with-cisplatin-and-paclitaxel-results-of-a-randomized-phase-ii-study-jortc-kmp-02
#12
Shunsuke Ohnishi, Hidemichi Watari, Maki Kanno, Yoko Ohba, Satoshi Takeuchi, Tempei Miyaji, Shunsuke Oyamada, Eiji Nomura, Hidenori Kato, Toru Sugiyama, Masahiro Asaka, Noriaki Sakuragi, Takuhiro Yamaguchi, Yasuhito Uezono, Satoru Iwase
OBJECTIVE: Rikkunshito, an herbal medicine, is widely prescribed in Japan for the treatment of anorexia and functional dyspepsia, and has been reported to recover reductions in food intake caused by cisplatin. We investigated whether rikkunshito could improve chemotherapy-induced nausea and vomiting (CINV) and anorexia in patients treated with cisplatin. METHODS: Patients with uterine cervical or corpus cancer who were to receive cisplatin (50 mg/m² day 1) and paclitaxel (135 mg/m² day 0) as first-line chemotherapy were randomly assigned to the rikkunshito group receiving oral administration on days 0-13 with standard antiemetics, or the control group receiving antiemetics only...
March 17, 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28656703/examination-of-competing-diagnostic-models-of-functional-gastrointestinal-disorders-related-to-pain-in-children
#13
J V Schurman, B T Karazsia, C A Friesen
BACKGROUND: There have been no empirical validations of the Rome III or Rome IV criteria in children. The aim of the current study was to examine whether symptoms naturally occur in a pattern consistent with Rome III and/or Rome IV pediatric criteria for functional dyspepsia (FD) and irritable bowel syndrome (IBS). METHODS: We conducted a retrospective cohort study of 250 children, ages 8-17 years, presenting to an abdominal pain clinic with pain of at least 8 weeks duration...
June 28, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28651565/prokinetics-for-the-treatment-of-functional-dyspepsia-bayesian-network-meta-analysis
#14
Young Joo Yang, Chang Seok Bang, Gwang Ho Baik, Tae Young Park, Suk Pyo Shin, Ki Tae Suk, Dong Joon Kim
BACKGROUND: Controversies persist regarding the effect of prokinetics for the treatment of functional dyspepsia (FD). This study aimed to assess the comparative efficacy of prokinetic agents for the treatment of FD. METHODS: Randomized controlled trials (RCTs) of prokinetics for the treatment of FD were identified from core databases. Symptom response rates were extracted and analyzed using odds ratios (ORs). A Bayesian network meta-analysis was performed using the Markov chain Monte Carlo method in WinBUGS and NetMetaXL...
June 26, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28634390/increased-glutamate-in-somatosensory-cortex-in-functional-dyspepsia
#15
Arthur D P Mak, Georg Northoff, David K W Yeung, Winnie C W Chu, Steve C N Hui, Cynthia Cheung, Jessica Ching, Linda Lam, Sing Lee, Justin Wu
Functional Dyspepsia-Post-prandial Distress Syndrome (FD-PDS) was associated with mood-related increases in resting activity and lowered activation threshold in the somatosensory cortex (SSC), insula and perigenual anterior cingulate cortex(pgACC) in functional imaging studies. The underlying cortical neurochemical changes are unknown. We performed proton Magnetic Resonance Spectroscopy (1H-MRS) on 17 consecutive tertiary clinic-recruited psychotropic-naïve Rome III FD-PDS female and 17 age-sex matched healthy controls...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28631728/acg-and-cag-clinical-guideline-management-of-dyspepsia
#16
Paul M Moayyedi, Brian E Lacy, Christopher N Andrews, Robert A Enns, Colin W Howden, Nimish Vakil
We have updated both the American College of Gastroenterology (ACG) and the Canadian Association of Gastroenterology (CAG) guidelines on dyspepsia in a joint ACG/CAG dyspepsia guideline. We suggest that patients ≥60 years of age presenting with dyspepsia are investigated with upper gastrointestinal endoscopy to exclude organic pathology. This is a conditional recommendation and patients at higher risk of malignancy (such as spending their childhood in a high risk gastric cancer country or having a positive family history) could be offered an endoscopy at a younger age...
June 20, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28616042/cerebral-mechanism-of-puncturing-at-he-mu-point-combination-for-functional-dyspepsia-study-protocol-for-a-randomized-controlled-parallel-trial
#17
Shuai Yin, Yuan Chen, Du Lei, Rui-Rui Sun, Ting-Ting Ma, Pei-Min Feng, Zhao-Xuan He, Xue-Ling Suo, Pei-Hong Ma, Yu-Zhu Qu, Ke Qiu, Miao-Miao Jing, Qi-Yong Gong, Fan-Rong Liang, Jiao Chen, Fang Zeng
Acupuncture is widely used to treat functional dyspepsia with satisfactory outcomes. Combination of the He and Mu acupoints is commonly used and has a synergistic effect on functional dyspepsia; however, its underlying mechanisms remain unclear. Therefore, a randomized controlled parallel clinical trial is currently underway at Chengdu University of Traditional Chinese Medicine, China. This trial is designed to explore the efficacy of and central responses to the He-Mu point combination in patients with functional dyspepsia using functional magnetic resonance imaging...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28605740/a-randomized-double-blind-pilot-study-of-the-effect-of-famotidine-on-acotiamide-treatment-for-functional-dyspepsia
#18
Mariko Hojo, Akihito Nagahara, Daisuke Asaoka, Tsutomu Takeda, Kentaro Izumi, Kohei Matsumoto, Hiroya Ueyama, Yuji Shimada, Kenshi Matsumoto, Shuko Nojiri, Sumio Watanabe
BACKGROUND/AIMS: Acotiamide, a prokinetic drug, is used to treat functional dyspepsia (FD), especially postprandial distress syndrome (PDS). However, a treatment for FD patients with PDS and/or epigastric pain syndrome (EPS) has not been established. We investigated the efficacy of famotidine in combination with acotiamide for FD. METHODS: Fifty blindly randomized FD patients received placebo with acotiamide, or famotidine with acotiamide, for 4 weeks. Treatment efficacy was assessed by overall treatment effects (OTE), total, PDS and EPS symptom scores, and impairment of quality of life (QOL)...
June 13, 2017: Digestion
https://www.readbyqxmd.com/read/28589578/editorial-functional-dyspepsia-a-disorder-of-duodenal-permeability
#19
EDITORIAL
N Vakil
No abstract text is available yet for this article.
July 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28577245/from-harmful-treatment-to-secondary-gain-adverse-event-reporting-in-dyspepsia-and-gastroparesis
#20
Klaus Bielefeldt
INTRODUCTION: Medical management of gastroparesis and functional dyspepsia remains difficult with several recent trials showing limited or no benefit. If treatment comes with only marginal improvements, concerns about adverse events become more relevant. We therefore examined the type and outcomes of side effects submitted to a public repository. METHODS: We searched the Federal Adverse Event Reporting System for reports associated with the treatment of dyspepsia or gastroparesis...
June 2, 2017: Digestive Diseases and Sciences
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