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Foot neuropathy

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https://www.readbyqxmd.com/read/28942488/psychological-and-biomechanical-aspects-of-patient-adaptation-to-diabetic-neuropathy-and-foot-ulceration
#1
REVIEW
Loretta Vileikyte, Ryan T Crews, Neil D Reeves
PURPOSE OF REVIEW: The purpose of this review was to elucidate how psychological and biomechanical factors interrelate in shaping patients' experience with diabetic symmetric polyneuropathy (DSPN) and its sequela-diabetic foot ulceration (DFU). RECENT FINDINGS: Recent findings emphasize the importance not only of neuropathic pain but also of other DSPN symptoms, such as unsteadiness. We highlight the negative spiral between unsteadiness, falls, and psychological distress...
September 23, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28942323/the-quest-for-more-research-on-painful-diabetic-neuropathy
#2
P P Nawroth, M Bendszus, M Pham, J Jende, S Heiland, S Ries, C Schumann, M Schmelz, S Schuh-Hofer, R D Treede, R Kuner, D Oikonomou, J B Groener, S Kopf
A 62-year-old diabetologist diagnosed himself to have diabetes type-2, with an HbA1c of 9.5. Five months after lifestyle intervention and a multi-drug approach, HbA1c was 6.3, systolic blood pressure was below 135 mmHg and BMI reduced to 27. But he suffered from severe painful diabetic neuropathy. Therefore he decided to visit his friend, a famous neuroscientist at an even more famous university. He asked him several plain questions: 1. What is the natural course of painful diabetic neuropathy? 2. Why do I have, despite almost normalizing HbA1c, more problems than before? 3...
September 20, 2017: Neuroscience
https://www.readbyqxmd.com/read/28942120/immobilization-induced-osteolysis-and-recovery-in-neuropathic-foot-impairments
#3
David R Sinacore, Mary K Hastings, Kathryn L Bohnert, Michael J Strube, David J Gutekunst, Jeffrey E Johnson
BACKGROUND: Neuropathic foot impairments treated with immobilization and off-loading result in osteolysis. In order to prescribe and optimize rehabilitation programs after immobilization we need to understand the magnitude of pedal osteolysis after immobilization and the time course for recovery. OBJECTIVE: To determine differences in a) foot skin temperature; b) calcaneal bone mineral density (BMD) after immobilization; c) calcaneal BMD after 33-53weeks of recovery; and d) percent of feet classified as osteopenic or osteoporotic after recovery in participants with neuropathic plantar ulcers (NPU) compared to Charcot neuroarthropathy (CNA)...
September 20, 2017: Bone
https://www.readbyqxmd.com/read/28936434/prevalence-of-diabetic-foot-ulceration-and-associated-risk-factors-an-old-and-still-major-public-health-problem-in-khartoum-sudan
#4
Ahmed O Almobarak, Heitham Awadalla, Mugtaba Osman, Mohamed H Ahmed
BACKGROUND: Diabetic foot ulceration (DFU) is a major health problem across the globe. The objective of this study is to determine the prevalence of DFU and its associated risk factors in Sudanese individuals with diabetes. METHODS: Three hundred and ten individuals with type 2 diabetes, who have been on treatment for DM for at least 1 year and volunteered to participate, were enrolled in this study. Participants were interviewed using standardized pretested questionnaire to record medical history, socio-demographic, life style characteristics and presence of DFU...
September 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28930549/growth-factors-in-the-pathogenesis-of-diabetic-foot-ulcers
#5
Min Qi, Qiuhong Zhou, Weiqi Zeng, Lisha Wu, Shuang Zhao, Wangqing Chen, Chang Luo, Minxue Shen, Jianglin Zhang, Can-E Tang
Foot ulcers affect 15% of patients with diabetes, resulting in a great health burden. The occurrence and development of diabetic foot ulcers is associated with neuropathy, peripheral arterial disease, and infection. Several growth factors are involved in these processes, including epidermal growth factor, vascular endothelial growth factor, transforming growth factor-beta, fibroblast growth factor, and erythropoietin, which could promote wound healing of patients with diabetes. Thus, this review discusses the role of these growth factors in the pathogenesis of diabetic foot ulcers, aiming to achieve novel insights into the management of diabetic foot ulcers...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28886703/factors-associated-with-foot-ulceration-and-amputation-in-adults-on-dialysis-a-cross-sectional-observational-study
#6
Michelle R Kaminski, Anita Raspovic, Lawrence P McMahon, Katrina A Lambert, Bircan Erbas, Peter F Mount, Peter G Kerr, Karl B Landorf
BACKGROUND: Adults on dialysis are at increased risk of foot ulceration, which commonly precedes more serious lower limb complications, including amputation. Limited data exist regarding the prevalence and factors associated with foot disease in this population. Hence, this study set out to investigate factors associated with foot ulceration and amputation in a dialysis cohort. METHODS: This study presents a cross-sectional analysis of baseline data from a multi-center prospective cohort study...
September 8, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28874161/altered-semmes-weinstein-monofilament-test-results-are-associated-with-oxidative-stress-markers-in-type-2-diabetic-subjects
#7
Sergio Martinez-Hervás, Mercedes Molina Mendez, José Folgado, Carmen Tormos, Pilar Ascaso, Marta Peiró, Jose T Real, Juan F Ascaso
BACKGROUND: Different lines of evidence suggest that oxidative stress (OS) is implicated in the pathogenesis of diabetic neuropathy. The Semmes-Weinstein monofilament (SWM) test is an efficient tool for evaluating diabetic polyneuropathy and diabetic foot. In this study, we analyzed the association between OS markers and altered SWM test results in type 2 diabetes (T2DM) patients. METHODS: Seventy T2DM patients were studied and 34 showed altered SWM results. The clinical and biochemical parameters were determined using standardized methods...
September 6, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28872686/weak-bones-in-diabetes-mellitus-an-update-on-pharmaceutical-treatment-options
#8
REVIEW
Daphne P L Lin, Crispin R Dass
OBJECTIVES: Diabetes mellitus is often associated with a number of complications such as nephropathy, neuropathy, retinopathy and foot ulcers. However, weak bone is a diabetic complication that is often overlooked. Although the exact mechanism for weak bones within diabetes mellitus is unclear, studies have shown that the mechanism does differ in both type I (T1DM) and type II diabetes (T2DM). This review, however, investigates the application of mesenchymal stem cells, recombinant human bone morphogenetic protein-2, teriparatide, insulin administration and the effectiveness of a peroxisome proliferator-activated receptor-ϒ modulator, netoglitazone in the context of diabetic weak bones...
September 5, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28871710/importance-of-education-in-the-prevention-of-diabetic-foot-syndrome
#9
Jitka Pokorna
To the Editor, Diabetic foot syndrome (DFS) is defined by the WHO as ulceration or destruction of foot tissue in diabetic patients associated with neuropathy, with different degrees of the disease existing and frequently also with infection. The statistics are frightening: more than million amputations are annually carried out worldwide due to diabetic foot (Foster and Lauver 2014) and these amputations represent as far as 70% of all non-traumatic amputations. In 2013, 861 647 patients were treated for diabetes mellitus in Czech Republic, including 44 657 patients with diabetic foot syndrome and 11 168 patients had to experience the amputation of lower limb due to this condition...
August 5, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28867530/clinical-and-microbiological-profile-of-diabetic-foot-ulcer-patients-in-a-tertiary-care-hospital
#10
Ramya Kateel, Alfred J Augustine, Shivananda Prabhu, Sheetal Ullal, Manohar Pai, Prabha Adhikari
AIM: To evaluate the clinical and microbiological profile of diabetic foot ulcer patients admitted to a tertiary care hospital. METHODOLOGY: This study recruited 120 diabetic foot ulcer patients of all grade. Their medical records were evaluated retrospectively. RESULTS: We found that median age of patient was 60(52, 67.75) years. 68.3% of patients were males. Median duration of diabetes mellitus was 15(10, 20) years. Mean HbA1C and fasting glucose was 10...
August 26, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28864841/diabetic-neuropathy-and-gait-a-review
#11
REVIEW
Uazman Alam, David R Riley, Ravinder S Jugdey, Shazli Azmi, Satyan Rajbhandari, Kristiaan D'Août, Rayaz A Malik
Diabetic peripheral neuropathy (DPN) is a major sequela of diabetes mellitus and may have a detrimental effect on the gait of people with this complication. DPN causes a disruption in the body's sensorimotor system and is believed to affect up to 50% of patients with diabetes mellitus, dependent on the duration of diabetes. It has a major effect on morbidity and mortality. The peripheral nervous system controls the complex series of events in gait through somatic and autonomic functions, careful balancing of eccentric and concentric muscle contractions and a reliance on the sensory information received from the planter surface...
September 1, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28859075/plantar-pressures-are-elevated-in-people-with-longstanding-diabetes-related-foot-ulcers-during-follow-up
#12
Malindu E Fernando, Robert G Crowther, Peter A Lazzarini, Saiumaeswar Yogakanthi, Kunwarjit S Sangla, Petra Buttner, Rhondda Jones, Jonathan Golledge
OBJECTIVE: High plantar pressures are implicated in the development of diabetes-related foot ulcers. Whether plantar pressures remain high in patients with chronic diabetes-related foot ulcers over time is uncertain. The primary aim of this study was to compare plantar pressures at baseline and three and six months later in participants with chronic diabetes-related foot ulcers (cases) to participants without foot ulcers (controls). METHODS: Standardised protocols were used to measure mean peak plantar pressure and pressure-time integral at 10 plantar foot sites (the hallux, toes, metatarsals 1 to 5, mid-foot, medial heel and lateral heel) during barefoot walking...
2017: PloS One
https://www.readbyqxmd.com/read/28853612/foot-problems-in-older-adults-associations-with-incident-falls-frailty-syndrome-and-sensor-derived-gait-balance-and-physical-activity-measures
#13
Amy Muchna, Bijan Najafi, Christopher S Wendel, Michael Schwenk, David G Armstrong, Jane Mohler
BACKGROUND: Research on the relationship between foot problems and frailty is sparse and could be elucidated via advances in wearable sensor-based measures of gait, balance, and physical activity (PA). This study examined the impact of foot problems on likelihood of falls, frailty syndrome, motor performance, and PA in community-dwelling older adults. METHODS: Arizona Frailty Cohort Study participants (community-dwelling adults 65 years and older without baseline cognitive deficit, severe movement disorders, or recent stroke) underwent Fried frailty and foot assessment...
August 30, 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28827977/ankle-foot-orthosis-made-by-3d-printing-technique-and-automated-design-software
#14
Yong Ho Cha, Keun Ho Lee, Hong Jong Ryu, Il Won Joo, Anna Seo, Dong-Hyeon Kim, Sang Jun Kim
We described 3D printing technique and automated design software and clinical results after the application of this AFO to a patient with a foot drop. After acquiring a 3D modelling file of a patient's lower leg with peroneal neuropathy by a 3D scanner, we loaded this file on the automated orthosis software and created the "STL" file. The designed AFO was printed using a fused filament fabrication type 3D printer, and a mechanical stress test was performed. The patient alternated between the 3D-printed and conventional AFOs for 2 months...
2017: Applied Bionics and Biomechanics
https://www.readbyqxmd.com/read/28817962/patients-with-diabetic-foot-disease-fear-major-lower-extremity-amputation-more-than-death
#15
Dane K Wukich, Katherine M Raspovic, Natalie C Suder
BACKGROUND: The aim of this study was to identify the most-feared complications of diabetes mellitus (DM), comparing those with diabetic foot pathology with those without diabetic foot pathology. METHODS: We determined the frequency of patients ranking major lower-extremity amputation (LEA) as their greatest fear in comparison to blindness, death, diabetic foot infection (DFI), or end-stage renal disease (ESRD) requiring dialysis. We further categorized the study group patients (N = 207) by their pathology such as diabetic foot ulcer (DFU), Charcot neuroarthropathy, foot infection, or acute neuropathic fractures and dislocations...
February 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28802220/comparison-of-lower-limb-muscle-strength-between-diabetic-neuropathic-and-healthy-subjects-using-opensim
#16
Alessandra Scarton, Ilse Jonkers, Annamaria Guiotto, Fabiola Spolaor, Gabriella Guarneri, Angelo Avogaro, Claudio Cobelli, Zimi Sawacha
Diabetes neuropathy and vasculopathy are the two major complications of diabetes mellitus, leading to diabetic foot disease, of which the worst consequences are plantar ulcers and amputations. Motor impairments like joint stiffness and loss of balance are distinctive effects of diabetes and they have been extensively explored. However, while altered muscle function has been also assessed through experimentally measured surface electromyography, little is known about muscle forces. The objective of this study was to estimate muscle forces in subjects with diabetes and to use these data to identify differences with respect to a population of healthy subjects matched for age and BMI...
July 31, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28791310/prevalence-of-diabetic-foot-ulcer-and-associated-factors-among-adult-diabetic-patients-who-attend-the-diabetic-follow-up-clinic-at-the-university-of-gondar-referral-hospital-north-west-ethiopia-2016-institutional-based-cross-sectional-study
#17
Tesfamichael G Mariam, Abebaw Alemayehu, Eleni Tesfaye, Worku Mequannt, Kiber Temesgen, Fisseha Yetwale, Miteku Andualem Limenih
Diabetes mellitus is a metabolic disorder which is characterized by multiple long-term complications that affect almost every system in the body. Foot ulcers are one of the main complications of diabetes mellitus. However, there is limited evidence on the occurrence of foot ulcer and influencing factors in Ethiopia. An institutional-based cross-sectional study was conducted in Gondar University Hospital, Ethiopia, to investigate foot ulcer occurrence in diabetic patients. Systematic random sampling was used to select 279 study participants...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28789834/diabetes-complications-in-sudanese-individuals-with-type-2-diabetes-overlooked-problems-in-sub-saharan-africa
#18
Heitham Awadalla, Sufian K Noor, Wadie M Elmadhoun, Ahmed O Almobarak, Nehad E Elmak, Sulaf I Abdelaziz, Amel A Sulaiman, Mohamed H Ahmed
BACKGROUND: Diabetes mellitus (DM) is a major health problem in Sudan and is a leading cause of morbidity and mortality. The objective of this study is to determine the prevalence of complications of type 2 diabetes across different cities in the country. METHODS: Individuals with type 2 diabetes, who have been on treatment for DM for at least one year and volunteered to participate, were selected from two diabetes centers in Sudan (Khartoum and Atbara). Participants were interviewed using standardized pretested questionnaire to record medical history, socio-demographic, life style characteristics and presence of complications of diabetes...
July 29, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28774662/hamilton-rating-scale-for-depression-24-ham-d24-as-a-novel-predictor-for-diabetic-microvascular-complications-in-type-2-diabetes-mellitus-patients
#19
Shuo Pan, Zhong-Wei Liu, Shuang Shi, Xun Ma, Wen-Qian Song, Gong-Chang Guan, Yong Zhang, Shun-Ming Zhu, Fu-Qiang Liu, Bo Liu, Zhi-Guo Tang, Jun-Kui Wang, Ying Lv
The study was designed to investigate whether the hamilton rating scale for depression (24-items) (HAM-D24) can be used to predict the diabetic microvascular complications in type 2 diabetes mellitus (T2DM) patients. 288 hospitalized patients with T2DM were enrolled. Their diabetic microvascular complications including diabetic nephropathy, diabetic retinopathy, diabetic peripheral neuropathy and diabetic foot as well as demographic, clinical data, blood samples and echocardiography were documented. All the enrolled patients received HAM-D24 evaluation...
July 26, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28765052/predictors-of-lower-extremity-amputation-and-reamputation-in-the-diabetic-foot
#20
Erdinc Acar, Burkay Kutluhan Kacıra
In the present study, we aimed to identify the comorbidities that would be predictive of requiring lower extremity amputation or reamputation for diabetic foot wounds. We performed a retrospective review of 132 consecutive patients who had undergone lower extremity amputations (110 patients) or reamputations (22 patients) for diabetic wounds from January 2013 to March 2016. We used multivariate logistic regression to calculate the odds ratios (ORs) for amputation and reamputation for various comorbidities. The ORs of undergoing amputation were greatest for adult males (OR 5...
July 29, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
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