Ulfah Mahfufah, Muhammad Alif Sya'ban Mahfud, Mesakh Diki Saputra, Sumayya Binti Abd Azis, Azimah Salsabila, Rangga Meidianto Asri, Habibie Habibie, Yessie Sari, Risfah Yulianty, Ahmad R Alsayed, Boonnada Pamornpathomkul, Maria Mir, Andi Dian Permana
Fluconazole (FNL) is one of the first-line treatments for fungal keratitis as it is an effective broad-spectrum antimicrobial commonly administered orally or topically. However, FNL has a very low water solubility, limiting its drug formulation, therapeutic application, and bioavailability through tissues. To overcome these limitations, this study aimed to develop FNL inclusion complexes (FNL-IC) with cyclodextrin (α-cyclodextrin, sulfobutylether-β-cyclodextrin, and hydroxypropyl-γ cyclodextrin) and incorporate it into a dissolvable microneedle (DMN) system to improve solubility and drug penetration...
May 10, 2024: ACS Applied Materials & Interfaces