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https://www.readbyqxmd.com/read/28081296/short-synthetic-%C3%AE-helical-forming-peptide-amphiphiles-for-fungal-keratitis-treatment-in-vivo
#1
Hong Wu, Shaoqiong Liu, Nikken Wiradharma, Zhan Yuin Ong, Yan Li, Yi Yan Yang, Jackie Y Ying
The emergence of fungal keratitis is on the rise globally. However, current antifungal therapeutics are ineffective in severe keratomycosis. Previously reported α-helical peptides comprising 8-14 amino acids demonstrate broad-spectrum antimicrobial activity both in vitro and in vivo. Here, α-helical peptides of the optimized sequences are investigated for antifungal biofilm in vitro and in vivo using a fungal biofilm-caused mouse keratitis model. The peptides with the optimal composition demonstrate higher α-helical propensity and improve antifungal activity in dispersing Candida albicans biofilm in vitro...
January 12, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28077516/early-onset-invasive-candidiasis-in-extremely-low-birth-weight-infants-perinatal-acquisition-predicts-poor-outcome
#2
Michelle Barton, Alex Shen, Karel O'Brien, Joan L Robinson, H Dele Davies, Kim Simpson, Elizabeth Asztalos, Joanne Langley, Nicole Le Saux, Reginald Sauve, Anne Synnes, Ben Tan, Louis de Repentigny, Earl Rubin, Chuck Hui, Lajos Kovacs, Yvonne Cw Yau, Susan E Richardson
BACKGROUND: Neonatal invasive candidiasis (IC)presenting in the first week of life is less common and less well described than later onset IC. Risk factors, clinical features and disease outcomeshave not been studied in early onset disease (EOD, ≤7d) or compared to late onset disease (LOD, >7d). METHODS: All extremely low birth weight (ELBW, <1000g) cases with IC and controls froma multicentre study of neonatal candidiasisenrolledfrom 2001 to 2003were included in this study...
January 11, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28074638/clinical-management-of-candida-albicans-keratomycosis-in-a-bottlenose-dolphin-tursiops-truncatus
#3
Claire A Simeone, John P Traversi, Jenny M Meegan, Carolina LeBert, Carmen M H Colitz, Eric D Jensen
OBJECTIVE: Corneal ulceration secondary to trauma commonly affects marine mammals, often with opportunistic secondary bacterial or fungal infections. This report characterizes the combined use of auriculopalpebral and ophthalmic nerve blocks, adipose-derived stem cells, and subconjunctival injections for successful treatment of corneal trauma and infection in dolphins. ANIMAL STUDIED: An 11-year-old, female bottlenose dolphin (Tursiops truncatus) presented with bilateral diffuse corneal opacities, which progressed to keratomycosis caused by Candida albicans...
January 11, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28072890/candida-albicans-survival-growth-and-biofilm-formation-are-differently-affected-by-mouthwashes-an-in-vitro-study
#4
Simona Paulone, Giulia Malavasi, Andrea Ardizzoni, Carlotta Francesca Orsi, Samuele Peppoloni, Rachele Giovanna Neglia, Elisabetta Blasi
Candida albicans is the most common cause of oral mycoses. The aim of the present study was to investigate in vitro the susceptibility of C. albicans to mouthwashes, in terms of growth, survival and biofilm formation. Candida albicans, laboratory strain SC5314, and 7 commercial mouthwashes were employed: 3 with 0.2% chlorhexidine digluconate; 1 with 0.06% chlorhexidine digluconate and 250 ppm F- sodium fluoride; 3 with fluorine-containing molecules. None of the mouthwashes contained ethanol in their formulations...
January 9, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28072553/decreased-killing-activity-of-micafungin-against-candida-guilliermondii-candida-lusitaniae-and-candida-kefyr-in-the-presence-of-human-serum
#5
Qasem Saleh, Renátó Kovács, Gábor Kardos, Rudolf Gesztelyi, Tamás Kardos, Aliz Bozó, László Majoros
Currently, echinocandins are first-line drugs for treatment of invasive candidiasis. However, data on how serum influences killing activity of echinocandins against uncommon Candida species are limited. Therefore, the killing activity of micafungin in RPMI-1640 and in 50% serum was compared against Candida guilliermondii, Candida lusitaniae, and Candida kefyr. Minimum inhibitory concentration (MIC) ranges in RPMI-1640 were 0.5-1, 0.12-0.25, and 0.06-0.12 mg/L, respectively. In 50% serum, MICs increased 32- to 256-fold...
January 10, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28069208/ultrasound-pretreatment-as-a-novel-approach-for-intensification-of-lipase-catalyzed-esterification-of-tricaprylin
#6
Snehal B More, Jyotsna T Waghmare, Parag R Gogate
The current work deals with ultrasound assisted intensification of synthesis of tricaprylin based on the enzyme catalyzed reaction of caprylic acid and glycerol with novel approach of using ultrasound in only the initial stages of the reaction. Two types of immobilized lipases as Lipozyme RM (Rhizomucor miehei) and Novozym 435 (Candida antarctica) have been used in the work. The effect of ultrasonic conditions such as treatment time and power as well as the reaction conditions such as substrate molar ratio, reaction time and enzyme loading on the yield of tricaprylin has been investigated...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28067644/eco-friendly-process-combining-physical-chemical-and-biological-technics-for-the-fermented-dairy-products-waste-pretreatment-and-reuse
#7
Mariam Kasmi, Moktar Hamdi, Ismail Trabelsi
Residual fermented dairy products resulting from process defects or from expired shelf life products are considered as waste. Thus, dairies wastewater treatment plants (WWTP) suffer high input effluents polluting load. In this study, fermented residuals separation from the plant wastewater is proposed. In the aim to meet the municipal WWTP input limits, a pretreatment combining physical-chemical and biological processes was investigated to reduce residual fermented dairy products polluting effect. Yoghurt (Y) and fermented milk products (RL) were considered...
January 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28063751/mechanisms-of-inactivation-of-candida-humilis-and-saccharomyces-cerevisiae-by-pulsed-electric-fields
#8
Qi-Xing Ou, Marija Nikolic-Jaric, Michael Gänzle
AIMS: This study aimed to determine how electric field strength, pulse width and shape, and specific energy input relate to the effect of pulsed electric fields (PEF) on viability and membrane permeabilization in Candida humilis and Saccharomyces cerevisiae suspended in potassium phosphate buffer. METHODS AND RESULTS: Cells were treated with a micro-scale system with parallel plate electrodes. Propidium iodide was added before or after treatments to differentiate between reversible and irreversible membrane permeabilization...
December 30, 2016: Bioelectrochemistry
https://www.readbyqxmd.com/read/28063305/inhibitory-effects-of-lactobacillus-rhamnosus-and-lactobacillus-casei-on-candida-biofilm-of-denture-surface
#9
Young-Gyun Song, Sung-Hoon Lee
OBJECTIVE: Candida albicans biofilm is associated with denture-related stomatitis and oral candidiasis of elderly. Probiotics are beneficial bacteria and have antibacterial activity against pathogenic bacteria. The purpose of this study was to investigate the antifungal activity of various probiotics against C. albicans and the inhibitory effects of probiotics on Candida biofilm on the denture surface. DESIGN: The spent culture media of various probiotics were investigated the antifungal efficacy against C...
December 31, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/28058136/appropriate-treatment-of-invasive-candidiasis-in-icu-timing-colonization-index-candida-score-biomarkers-towards-de-escalation
#10
Francesco Giuseppe De Rosa, Silvia Corcione, Giorgia Montrucchio, Luca Brazzi, Giovanni Di Perri
No abstract text is available yet for this article.
December 2016: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/28053891/evaluation-of-wound-healing-anti-microbial-and-antioxidant-potential-of-pongamia-pinnata-in-wistar-rats
#11
Deepak Dwivedi, Mona Dwivedi, Sourabh Malviya, Vinod Singh
OBJECTIVE: To investigate wound healing, antimicrobial and antioxidant activity of leaf extract of Pongamia Pinnata. MATERIALS AND METHODS: Methanolic extracts of P. pinnata leaf were studied for wound healing efficiency, and was assessed by the rate of wound contraction, tensile strength, breaking strength, hydroxyproline and hexosamine content, along with its effect on pro-inflammatory and anti-inflammatory cytokines was assessed using excision and incision model of wound repair in Wistar rats...
January 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28043539/invasive-forms-of-candida-and-aspergillus-in-sputum-samples-of-pulmonary-tuberculosis-patients-attending-the-tuberculosis-reference-laboratory-in-ghaemshahr-northern-iran-an-analysis-of-samples-collected-during-the-past-10years
#12
Mohammad Reza Jabbari Amiri, Seyed Reza Aghili, Tahereh Shokohi, Mohammad Taghi Hedayati, Mahdi Abastabar, Masoud Aliyali, Masoumeh Jabbari Amiri, Hamid Hasanpour
OBJECTIVE/BACKGROUND: Tuberculosis (TB) continues to be a major public health problem worldwide. This is especially true in Northern Iran, which has high TB prevalence. The chronic nature of this disease is further exacerbated if it is accompanied by fungal infection, which usually remains undiagnosed and thus untreated. Thus, mycotic infections add fatal dimensions to pulmonary TB. Our objective was to determine the prevalence of invasive forms of fungal elements in sputum samples collected from patients with pulmonary TB at a reference laboratory in Ghaemshahr, Northern Iran, during the past 10years...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28039272/micafungin-alters-the-amino-acid-nucleic-acid-and-central-carbon-metabolism-of-candida-albicans-at-subinhibitory-concentrations-novel-insights-into-mechanisms-of-action
#13
Aspasia Katragkou, Michael Williams, Sandi Sternberg, Dennis Pantazatos, Emmanuel Roilides, Thomas J Walsh
BACKGROUND: Echinocandins are an important class of antifungal agents in the treatment of invasive candidiasis. However, little is known about the metabolomic effects of echinocandins on Candida We therefore performed LC-high-resolution MS (LC-HRMS)-based metabolomics profiling of the response of Candida albicans cells to increasing concentrations of micafungin to determine the metabolic response of Candida to micafungin subinhibitory injury. METHODS: Isolates of C...
December 30, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28038478/activity-of-the-aqueous-extract-of-schinus-terebinthifolius-raddi-on-strains-of-the-candida-genus
#14
Kátia Andrea de Menezes Torres, Sônia Maria Rolim Rosa Lima, Suely Mitoi Ykko Ueda
Objectives To evaluate the antifungal susceptibility profile of the aqueous extract of the bark of Schinus terebinthifolius Raddi against the strains of the genus Candida. Methods By using the disk diffusion method, 50 samples of the genus Candida (Candida albicans; Candida krusei; Candida glabrata; and Candida tropicalis), isolated from patients receiving treatment at Hospital Santa Casa de Misericórdia de São Paulo, and 1 American Type Culture Collection (ATCC) sample of each species were tested against: the isolated aqueous extract of the bark of Schinus terebinthifolius Raddi, isolated nystatin, and the association of nystatin and the aqueous extract of Schinus terebinthifolius Raddi...
December 30, 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28032543/candida-albicans-biofilm-heterogeneity-does-not-influence-denture-stomatitis-but-strongly-influences-denture-cleansing-capacity
#15
Lindsay E O'Donnell, Hasanain K A Alalwan, Ryan Kean, Gareth Calvert, Christopher J Nile, David F Lappin, Douglas Roberston, Craig Williams, Gordon Ramage, Leighann Sherry
Approximately 20% of the UK population wear some form of denture prosthesis, resulting in denture stomatitis in half of these individuals. Candida albicans is primarily attributed as the causative agent, due to its biofilm forming ability. Recently, there has been increasing evidence of C. albicans biofilm heterogeneity and the negative impact it can have clinically; however, this phenomenon has yet to be studied in relation to denture isolates. The aims of this study were to evaluate C. albicans biofilm formation of clinical denture isolates in a denture environment, and assess antimicrobial activity of common denture cleansers against these tenacious communities...
December 29, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28025839/biological-and-structural-effects-of-the-conjugation-of-an-antimicrobial-decapeptide-with-saturated-unsaturated-methoxylated-and-branched-fatty-acids
#16
María Verónica Húmpola, María Carolina Rey, Nestor M Carballeira, Arturo Carlos Simonetta, Georgina Guadalupe Tonarelli
The increasing bacterial resistance against conventional antibiotics has led to the search for new antimicrobial drugs with different modes of action. Cationic antimicrobial peptides (AMPs) and lipopeptides are promising candidates to treat infections because they act on bacterial membranes causing rapid destruction of sensitive bacteria. In this study, a decapeptide named A2 (IKQVKKLFKK) was conjugated at the N-terminus with saturated, unsaturated, methoxylated and methyl -branched fatty acids of different chain lengths (C8 - C20), the antimicrobial and structural properties of the lipopeptides being then investigated...
December 26, 2016: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28024620/chitosan-banana-peel-powder-nanocomposites-for-wound-dressing-application-preparation-and-characterization
#17
Nagwa A Kamel, Salwa L Abd El-Messieh, Neveen M Saleh
Wound infection is a serious infection has been spread worldwide. In order to provide fast aid treatments for such infection, banana peels have been incorporated within chitosan as wound dressing. Banana was collected from Egyptian markets peeled and the dried peels were grounded to powder, Incorporated as nano fillers within chitosan matrix with different concentrations (0, 2, 5 and 10wt%). Glycerol was added as plasticizer and crosslinker to the membranes. The banana peel powder (BPP) particle shape and size were determined using Transmission Electron Microscope (TEM), The homogeneity and distribution of BPP in the membranes were investigated through Scanning Electron Microscope (SEM)...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024533/using-chitosan-nanoparticles-as-drug-carriers-for-the-development-of-a-silver-sulfadiazine-wound-dressing
#18
Gina S El-Feky, Samar S Sharaf, Amira El Shafei, Aisha A Hegazy
Burn wounds environment favors the growth of micro-organisms causing delay in wound healing. The traditional treatment with antimicrobial creams offer inaccurate doses. In the present study, a dressing coated with silver sulfadiazine (SSD) loaded chitosan nanoparticles (CSNPs) for the controlled-release of SSD into burn wound to control bacterial growth was investigated. CSNPs were formulated with different concentrations of chitosan and CM-β-CD and loaded with SSD complexed in 1:1 molar ratio with CM-β-CD, CSNPs were assessed for their particle size, polydispersity index, morphology and association efficiency...
February 20, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28018323/genetic-drivers-of-multidrug-resistance-in-candida-glabrata
#19
Kelley R Healey, Cristina Jimenez Ortigosa, Erika Shor, David S Perlin
Both the incidence of invasive fungal infections and rates of multidrug resistance associated with fungal pathogen Candida glabrata have increased in recent years. In this perspective, we will discuss the mechanisms underlying the capacity of C. glabrata to rapidly develop resistance to multiple drug classes, including triazoles and echinocandins. We will focus on the extensive genetic diversity among clinical isolates of C. glabrata, which likely enables this yeast to survive multiple stressors, such as immune pressure and antifungal exposure...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28011958/cationic-porphyrin-mediated-photodynamic-inactivation-of-candida-biofilms-and-the-effect-of-miconazole
#20
A Davies, S Gebremedhin, M Yee, R J Padilla, N Duzgunes, K Konopka, B Dorocka-Bobkowska
The formation of biofilms by Candida and the increasing resistance of Candida species to antifungals contribute to the high recurrence rates of denture stomatitis. This increase has stimulated an interest in antimicrobial photodynamic therapy (aPDT) as an alternative treatment. We examined the photoactivity of the porphyrin-based photosensitizer, TMP-1363, against biofilms of C. albicans, C. glabrata, C. tropicalis and C. parapsilosis, and the effect of the combined use of miconazole and aPDT. Biofilms of three American Type Culture Collection (ATCC) strains and four clinical isolates developed on poly(methyl methacrylate) (PMMA) disks, were incubated with miconazole, followed by treatment with TMP-1363 for 30 min at 37°C...
October 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
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