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https://www.readbyqxmd.com/read/28222507/recent-progress-in-alzheimer-s-disease-research-part-1-pathology
#1
Francis T Hane, Brenda Y Lee, Zoya Leonenko
The field of Alzheimer's disease (AD) research has grown exponentially over the past few decades, especially since the isolation and identification of amyloid-β from postmortem examination of the brains of AD patients. Recently, the Journal of Alzheimer's Disease (JAD) put forth approximately 300 research reports which were deemed to be the most influential research reports in the field of AD since 2010. JAD readers were asked to vote on these most influential reports. In this 3-part review, we review the results of the 300 most influential AD research reports to provide JAD readers with a readily accessible, yet comprehensive review of the state of contemporary research...
February 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28216088/sex-differences-in-the-neuro-immune-consequences-of-stress-focus-on-depression-and-anxiety
#2
REVIEW
Mandakh Bekhbat, Gretchen N Neigh
Women appear to be more vulnerable to the depressogenic effects of inflammation than men. Chronic stress, one of the most pertinent risk factors of depression and anxiety, is known to induce behavioral and affective-like deficits via neuroimmune alterations including activation of the brain's immune cells, pro-inflammatory cytokine expression, and subsequent changes in neurotransmission and synaptic plasticity within stress-related neural circuitry. Despite well-established sexual dimorphisms in the stress response, immunity, and prevalence of stress-linked psychiatric illnesses, much of current research investigating the neuroimmune impact of stress remains exclusively focused on male subjects...
February 16, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28215300/the-role-of-neurotrophins-in-inflammation-and-allergy
#3
S Manti, P Brown, M K Perez, G Piedimonte
Allergic inflammation is the result of a specific pattern of cellular and humoral responses leading to the activation of the innate and adaptive immune system, which, in turn, results in physiological and structural changes affecting target tissues such as the airways and the skin. Eosinophil activation and the production of soluble mediators such as IgE antibodies are pivotal features in the pathophysiology of allergic diseases. In the past few years, however, convincing evidence has shown that neurons and other neurosensory structures are not only a target of the inflammatory process but also participate in the regulation of immune responses by actively releasing soluble mediators...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28198833/neuroimmune-interactions-astrocytes
#4
Ioana Visan
No abstract text is available yet for this article.
February 15, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28198826/neuroimmune-interactions-ilc3s
#5
Ioana Visan
No abstract text is available yet for this article.
February 15, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28196545/roles-of-programmed-death-protein-1-programmed-death-ligand-1-in-secondary-brain-injury-after-intracerebral-hemorrhage-in-rats-selective-modulation-of-microglia-polarization-to-anti-inflammatory-phenotype
#6
Jie Wu, Liang Sun, Haiying Li, Haitao Shen, Weiwei Zhai, Zhengquan Yu, Gang Chen
BACKGROUND: Microglia and its polarization play critical roles in intracerebral hemorrhage-induced secondary brain injury. Programmed death protein 1/programmed death-ligand 1 has been reported to regulate neuroimmune cell functions. Signal transducers and activators of transcription 1 participate in microglia polarization, and programmed death protein 1/programmed death-ligand 1 could regulate the activation of signal transducers and activators of transcription 1. We herein show the critical role of programmed death protein 1/programmed death-ligand 1 in the polarization of microglia during intracerebral hemorrhage-induced secondary brain injury in rat models...
February 14, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28191519/a-little-help-from-steroids-in-oncology
#7
Dominique Lossignol
Steroids are widely used in oncology and have been demonstrated to possess an anticancer effect or antiswelling effect. They are considered to improve refractory symptoms such as dyspnea or gastrointestinal (GI) obstruction. However, their roles in nonspecific indications are not well proved. Clinical practice and several studies suggest that corticosteroids may be effective in the treatment of bone and neuropathic pain, when administered along with opioids and with other adjuvant analgesics. The decrease in pain intensity is probably connected with both anti-inflammatory and antiswelling effects as well as modulation of neuroimmune interactions and an inhibition of angiogenesis...
April 1, 2016: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/28190393/significance-of-cholinergic-and-peptidergic-nerves-in-stress-induced-ulcer-and-malt-lymphoma-formation
#8
Masahiko Nakamura, Anders Øverby, Akina Uehara, Masaya Oda, Shinichi Takahashi, Somay Y Murayama, Hidenori Matsui
: Backgound: The role of enteric nerves has previously been demonstrated in the formation of several gastric diseases. In the present review, the significance of the cholinergic nerves in stress-induced ulcer formation as well as the importance of substance P in the formation of gastric MALT lymphoma is discussed. METHODS: The stress-induced ulcer was induced by the plaster bandage methods in rats. The gastric MALT lymphoma was formed by the peroral infection of gastric mucosal homogenate of the infected mouse in C57BL/6 mice...
February 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28161508/contribution-of-neuroinflammation-and-immunity-to-brain-aging-and-the-mitigating-effects-of-physical-and-cognitive-interventions
#9
REVIEW
Svetlana Di Benedetto, Ludmila Müller, Elisabeth Wenger, Sandra Düzel, Graham Pawelec
It is widely accepted that the brain and the immune system continuously interact during normal as well as pathological functioning. Human aging is commonly accompanied by low-grade inflammation in both the immune and central nervous systems, thought to contribute to many age-related diseases. This review of the current literature focuses first on the normal neuroimmune interactions occurring in the brain, which promote learning, memory and neuroplasticity. Further, we discuss the protective and dynamic role of barriers to neuroimmune interactions, which have become clearer with the recent discovery of the meningeal lymphatic system...
February 1, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28159648/the-role-of-neuroimmune-signaling-in-alcoholism
#10
REVIEW
Fulton T Crews, Colleen J Lawrimore, T Jordan Walter, Leon G Coleman
Alcohol consumption and stress increase brain levels of known innate immune signaling molecules. Microglia, the innate immune cells of the brain, and neurons respond to alcohol, signaling through Toll-like receptors (TLRs), high-mobility group box 1 (HMGB1), miRNAs, pro-inflammatory cytokines and their associated receptors involved in signaling between microglia, other glia and neurons. Repeated cycles of alcohol and stress cause a progressive, persistent induction of HMGB1, miRNA and TLR receptors in brain that appear to underlie the progressive and persistent loss of behavioral control, increased impulsivity and anxiety, as well as craving, coupled with increasing ventral striatal responses that promote reward seeking behavior and increase risk of developing alcohol use disorders...
February 1, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28154473/neuropeptides-and-microglial-activation-in-inflammation-pain-and-neurodegenerative-diseases
#11
REVIEW
Lila Carniglia, Delia Ramírez, Daniela Durand, Julieta Saba, Juan Turati, Carla Caruso, Teresa N Scimonelli, Mercedes Lasaga
Microglial cells are responsible for immune surveillance within the CNS. They respond to noxious stimuli by releasing inflammatory mediators and mounting an effective inflammatory response. This is followed by release of anti-inflammatory mediators and resolution of the inflammatory response. Alterations to this delicate process may lead to tissue damage, neuroinflammation, and neurodegeneration. Chronic pain, such as inflammatory or neuropathic pain, is accompanied by neuroimmune activation, and the role of glial cells in the initiation and maintenance of chronic pain has been the subject of increasing research over the last two decades...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28118842/microglial-derived-mirna-let-7-and-hmgb1-contribute-to-ethanol-induced-neurotoxicity-via-tlr7
#12
Leon G Coleman, Jian Zou, Fulton T Crews
BACKGROUND: Toll-like receptor (TLR) signaling is emerging as an important component of neurodegeneration. TLR7 senses viral RNA and certain endogenous miRNAs to initiate innate immune responses leading to neurodegeneration. Alcoholism is associated with hippocampal degeneration, with preclinical studies linking ethanol-induced neurodegeneration with central innate immune induction and TLR activation. The endogenous miRNA let-7b binds TLR7 to cause neurodegeneration. METHODS: TLR7 and other immune markers were assessed in postmortem human hippocampal tissue that was obtained from the New South Wales Tissue Bank...
January 25, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28116953/brown-vialetto-van-laere-syndrome-as-a-mimic-of-neuroimmune-disorders
#13
Tyler Allison, Inés Roncero, Rob Forsyth, Keith Coffman, Jean-Baptiste Le Pichon
We present 3 patients identified at 2 different institutions with Brown-Vialetto-Van Laere syndrome. Each patient was initially diagnosed with a neuroimmune disorder for a period of a few weeks to a few months. In each case, genetic analysis revealed mutations in one of the riboflavin transporters, confirming Brown-Vialetto-Van Laere syndrome. It is likely that Brown-Vialetto-Van Laere syndrome is more common than previously reported, and because it mimics neuroimmune disorders, it may be misdiagnosed as such...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28112808/nerve-growth-factor-a-neuroimmune-crosstalk-mediator-for-all-seasons
#14
REVIEW
Stephen D Skaper
Neurotrophic factors comprise a broad family of biomolecules - most of which are peptides or small proteins - that support the growth, survival, and differentiation of both developing and mature neurons. The prototypical example and best-characterized neurotrophic factor is nerve growth factor (NGF) which is widely recognized as a target-derived factor responsible for the survival and maintenance of the phenotype of specific subsets of peripheral neurons and basal forebrain cholinergic nuclei during development and maturation...
January 23, 2017: Immunology
https://www.readbyqxmd.com/read/28107039/future-directions-in-the-study-of-early-life-stress-and-physical-and-emotional-health-implications-of-the-neuroimmune-network-hypothesis
#15
Camelia E Hostinar, Robin Nusslock, Gregory E Miller
Early-life stress is associated with increased vulnerability to physical and emotional health problems across the lifespan. The recently developed neuroimmune network hypothesis proposes that one of the underlying mechanisms for these associations is that early-life stress amplifies bidirectional crosstalk between the brain and the immune system, contributing to several mental and physical health conditions that have inflammatory underpinnings, such as depression and coronary heart disease. Neuroimmune crosstalk is thought to perpetuate inflammation and neural alterations linked to early-life stress exposure, and also foster behaviors that can further compromise health, such as smoking, drug abuse and consumption of high-fat diets...
January 20, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28104535/immune-mediated-processes-implicated-in-chemotherapy-induced-peripheral-neuropathy
#16
REVIEW
Justin G Lees, Preet G S Makker, Ryan S Tonkin, Munawwar Abdulla, Susanna B Park, David Goldstein, Gila Moalem-Taylor
Chemotherapy-induced peripheral neuropathy (CIPN) and associated neuropathic pain are challenging complications of cancer treatment. Many of the major classes of chemotherapeutics can cause neurotoxicity and significantly modulate the immune system. There is ongoing investigation regarding whether reciprocal crosstalk between the nervous and immune systems occurs and, indeed, contributes to neuropathic pain during treatment with chemotherapeutics. An emerging concept is that neuroinflammation is one of the major mechanisms underlying CIPN...
March 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28092662/neuroimmune-communication
#17
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
February 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28092377/neuroimmune-communication
#18
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
February 2017: Nature Immunology
https://www.readbyqxmd.com/read/28092371/neuroimmune-regulation-during-intestinal-development-and-homeostasis
#19
REVIEW
Henrique Veiga-Fernandes, Vassilis Pachnis
Interactions between the nervous system and immune system are required for organ function and homeostasis. Evidence suggests that enteric neurons and intestinal immune cells share common regulatory mechanisms and can coordinate their responses to developmental challenges and environmental aggressions. These discoveries shed light on the physiology of system interactions and open novel perspectives for therapy designs that target underappreciated neurological-immunological commonalities. Here we highlight findings that address the importance of neuroimmune cell units (NICUs) in intestinal development, homeostasis and disease...
February 2017: Nature Immunology
https://www.readbyqxmd.com/read/28091532/development-of-the-neuroimmune-modulator-ibudilast-for-the-treatment-of-alcoholism-a-randomized-placebo-controlled-human-laboratory-trial
#20
Lara A Ray, Spencer Bujarski, Steve Shoptaw, Daniel Jo Roche, Keith Heinzerling, Karen Miotto
Current directions in medication development for alcohol use disorder (AUD) emphasize the need to identify novel molecular targets and efficiently screen new compounds aimed at those targets. Ibudilast (IBUD) is a neuroimmune modulator that inhibits phosphodiesterases -4 and -10 and macrophage migration inhibitory factor and was recently found to reduce alcohol intake in rats by approximately 50%. To advance medications development for AUD, the present study consists of a randomized, crossover, double-blind, placebo-controlled laboratory study of IBUD in non-treatment seeking individuals with current (ie, past month) mild-to-severe AUD...
January 16, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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