Read by QxMD icon Read

Data display

Josef Parvizi, Kapil Gururangan, Babak Razavi, Chris Chafe
OBJECTIVE: The traditional approach to interpreting electroencephalograms (EEGs) requires physicians with formal training to visually assess the waveforms. This approach can be less practical in critical settings where a trained EEG specialist is not readily available to review the EEG and diagnose ongoing subclinical seizures, such as nonconvulsive status epilepticus. METHODS: We have developed a novel method by which EEG data are converted to sound in real time by letting the underlying electrophysiological signal modulate a voice tone that is in the audible range...
March 20, 2018: Epilepsia
Balaram Mohapatra, Pinaki Sar, Sufia Khannam Kazy, Mrinal Kumar Maiti, Tulasi Satyanarayana
Reductive transformation of toxic arsenic (As) species by As reducing bacteria (AsRB) is a key process in As-biogeochemical-cycling within the subsurface aquifer environment. In this study, we have characterized a Gram-stain-negative, non-spore-forming, rod-shaped As reducing bacterium designated KAs 5-3T, isolated from highly As-contaminated groundwater of India. Strain KAs 5-3T displayed high 16S rRNA gene sequence similarity to the members of the genus Pseudoxanthomonas, with P. mexicana AMX 26BT (99.25% similarity), P...
2018: PloS One
Catarina S H Jesus, Pedro Fernandes Cruz, Luis G Arnaut, Rui M M Brito, Carlos Serpa
The understanding of fast folding dynamics of single α-helices comes mostly from studies on rationally designed peptides displaying sequences with high helical propensity. The folding/unfolding dynamics and energetics of α-helix conformations in naturally occurring peptides remains largely unexplored. Here we report the study of a protein fragment analogue of the C-peptide from bovine pancreatic ribonuclease-A, RN80, a 13-amino acid residue peptide that adopts a highly populated helical conformation in aqueous solution...
March 20, 2018: Journal of Physical Chemistry. B
Jia-Nan Wang, Hao-Jian Zhang, Jia-Qi Li, Wan-Jing Ding, Zhong-Jun Ma
Nine new indolocarbazoles (1-9) were isolated from the marine-derived Streptomyces sp. DT-A61. Among them compounds 1-8 featured a hydroxy group at the C-3 or C-9 position. All purified compounds were identified by 1D and 2D NMR and HRESIMS data. The absolute configurations of 4-6, 8, and 9 were determined by electronic circular dichroism spectroscopic data. Compound 7 exhibited significant activity against human prostate PC-3 cancer cells with an IC50 value of 0.16 μM. Compounds 1, 5, 6, and 9 showed moderate inhibition against the same cell line with IC50 values of 8...
March 20, 2018: Journal of Natural Products
Zhila Maghbooli, Leila Khorrami-Nezhad, Elham Adabi, Majid Ramezani, Effat Asadollahpour, Farideh Razi, Mohammadtaher Rezanezhad
OBJECTIVE: The aim of the study was to investigate the association between high-density lipoprotein (HDL) and bone status taking into account serum vitamin D levels in postmenopausal Iranian women. METHODS: During January 2015 and February 2016, a total of 488 postmenopausal Iranian women participated in this cross-sectional study, all of whom were not taking osteoporosis medication and were not suffering from any chronic disorder. Dual X-ray absorptiometry was used to assess bone mineral density (BMD) of the total hip, femoral neck, and lumbar vertebrae (L2-L4)...
March 19, 2018: Menopause: the Journal of the North American Menopause Society
Fernanda Nunes, Daniela Pochmann, Amanda Staldoni Almeida, Daniela Melo Marques, Lisiane de Oliveira Porciúncula
Epidemiological studies suggest sex differences in attention deficit and hyperactivity disorder (ADHD) symptomatology. The potential benefits of caffeine have been reported in the management of ADHD, but its effects were not properly addressed with respect to sex differences. The present study examined the effects of caffeine (0.3 g/L) administered since childhood in the behavior and brain-derived neurotrophic factor (BDNF) and its related proteins in both sexes of a rat model of ADHD (spontaneously hypertensive rats-SHR)...
March 20, 2018: Molecular Neurobiology
Sonja Cabarkapa, Marlon Perera, Ken Sikaris, Jonathan S O'Brien, Damien M Bolton, Nathan Lawrentschuk
Background: This study aims to review current laboratory reporting strategies across Australia and New Zealand with a view to propose a more useful template for reporting serum testosterone in the context of prostate cancer. Materials and methods: Registered pathology laboratories in Australia and New Zealand were enrolled into the current study. An electronic or a phone survey was utilized to collect data from each participating laboratory. Obtained information included assay utilized, units reported, reference intervals, lowest reported value, and lowest detectable value...
March 2018: Prostate International
Xiangchun Li, Weiqi Xu, Wei Kang, Sunny H Wong, Mengyao Wang, Yong Zhou, Xiaodong Fang, Xiuqing Zhang, Huanming Yang, Chi H Wong, Ka F To, Stephen L Chan, Matthew T V Chan, Joseph J Y Sung, William K K Wu, Jun Yu
Objective: Hepatocellular carcinoma (HCC) is a highly heterogeneous disease with a dismal prognosis. However, driver genes and prognostic markers in HCC remain to be identified. It is hoped that in-depth analysis of HCC genomes in relation to available clinicopathological information will give rise to novel molecular prognostic markers. Methods: We collected genomic data of 1,061 HCC patients from previous studies, and performed integrative analysis to identify significantly mutated genes and molecular prognosticators...
2018: Theranostics
Francesca Macchi, José Manuel Rojas, Andrea Elizabeth Verna, Noemí Sevilla, Valentina Franceschi, Giulia Tebaldi, Sandro Cavirani, Verónica Martín, Gaetano Donofrio
Peste des Petits Ruminants Virus (PPRV) is an extremely infective morbillivirus that primarily affects goats and sheep. In underdeveloped countries where livestock are the main economical resource, PPRV causes considerable economic losses. Protective live attenuated vaccines are currently available but they induce antibody responses similar to those produced in PPRV naturally infected animals. Effective vaccines able to distinguish between vaccinated and naturally infected animals are required to PPRV control and eradication programs...
2018: Frontiers in Immunology
Shin-Ichi Hachisuka, Takaaki Sato, Haruyuki Atomi
Many organisms possess pathways that regenerate nicotinamide adenine dinucleotide (NAD+ ) from its degradation products, and two pathways are known to salvage NAD+ from nicotinamide (Nm). One is a four-step pathway that proceeds through deamination of Nm to nicotinic acid (Na) by Nm deamidase and phosphoribosylation to nicotinic acid mononucleotide (NaMN), followed by adenylylation and amidation. Another is a two-step pathway that does not involve deamination, and directly proceeds with the phosphoribosylation of Nm to nicotinamide mononucleotide (NMN), followed by adenylylation...
March 19, 2018: Journal of Bacteriology
Panayiota Kotsakiozi, Daniel Jablonski, Çetin Ilgaz, Yusuf Kumlutaş, Aziz Avcı, Shai Meiri, Yuval Itescu, Oleg Kukushkin, Václav Gvoždík, Giovanni Scillitani, Stephen Roussos, David Jandzik, Panagiotis Kasapidis, Petros Lymberakis, Nikos Poulakakis
The Kotschy's Gecko, Mediodactylus kotschyi, is a small gecko native to southeastern Europe and the Eastern Mediterranean. It displays great morphological variation with a large number of morphologically recognized subspecies. However, it has been suggested that it constitutes a species complex of several yet unrecognized species. In this study, we used multilocus sequence data (three mitochondrial and three nuclear gene fragments) to estimate the phylogenetic relationships of 129 populations covering a substantial part of the distribution range of the species...
March 16, 2018: Molecular Phylogenetics and Evolution
Claudia Belviso
The action of direct sonication (US) versus conventional hydrothermal method (HY) was investigated to determine the differences in the crystallization mechanism of zeolite formed from fly ash. The results showed that ultrasonic energy is decisive in very fast faujasite and A-type zeolite transformation into more stable sodalite phase. The data display the main presence of sodalite together with a low amount of faujasite and zeolite A after the first 3 h of sonication. The full transformation of the latter two phases into sodalite takes place after 1 h more of treatment...
May 2018: Ultrasonics Sonochemistry
John-Peter Ganda Mall, Lina Östlund-Lagerström, Carl Mårten Lindqvist, Samal Algilani, Dara Rasoal, Dirk Repsilber, Robert J Brummer, Åsa V Keita, Ida Schoultz
BACKGROUND: Despite the substantial number of older adults suffering from gastrointestinal (GI) symptoms little is known regarding the character of these complaints and whether they are associated with an altered intestinal barrier function and psychological distress. Our aim was to explore the relationship between self-reported gut health, intestinal permeability and psychological distress among older adults. METHODS: Three study populations were included: 1) older adults with GI symptoms (n = 24), 2) a group of older adults representing the general elderly population in Sweden (n = 22) and 3) senior orienteering athletes as a potential model of healthy ageing (n = 27)...
March 20, 2018: BMC Geriatrics
Xiaosong He, Danielle S Bassett, Ganne Chaitanya, Michael R Sperling, Lauren Kozlowski, Joseph I Tracy
Temporal lobe epilepsy tends to reshape the language system causing maladaptive reorganization that can be characterized by task-based functional MRI, and eventually can contribute to surgical decision making processes. However, the dynamic interacting nature of the brain as a complex system is often neglected, with many studies treating the language system as a static monolithic structure. Here, we demonstrate that as a specialized and integrated system, the language network is inherently dynamic, characterized by rich patterns of regional interactions, whose transient dynamics are disrupted in patients with temporal lobe epilepsy...
March 15, 2018: Brain: a Journal of Neurology
Maria Luger, Eva Winzer, Manuel Schätzer, Sabine Dämon, Nadine Moser, Karin Blagusz, Barbara Rittmannsberger, Julia Schätzer, Monika Lechleitner, Anita Rieder, Friedrich Hoppichler
Background: Sugar-sweetened beverages (SSBs) are a major source of free sugar intake and contribute to obesity and obesity-related diseases. Therefore, we analyzed the effect of a gradual sugar reduction strategy within the so-called 'beverage checklist' on free sugar content in beverages on sale in Austria. Methods: From 2010 until 2017, data on the amount of free sugar of sweetened beverages (sweetened with sugars, fruit juice and artificial sweeteners) with 0...
March 15, 2018: European Journal of Public Health
Kandace M Flanary, Jerald B Johnson
Mimicry can occur in several contexts, including sexual interactions. In some cases, males mimic females to gain access to potential mates. In contrast, there are relatively few examples of species where females mimic males, and we know very little about what drives these patterns. Two hypotheses have been advanced to explain female mimicry of males. The first is that mimicry is used to reduce harassment of females by males. The second is that mimicry is used to display dominance over other females. In this study, we tested these hypotheses in Brachyrhaphis fishes, wherein females of several species have pigmentation on their anal fin of the same coloration and shape, and in the same location, as the genitalia of males...
2018: PloS One
Huiling DI, Sisi Liang, Qingyang Li, Lei Shi, Ayaka Shima, Hecheng Meng, He Yan, Shinji Yamasaki
Bacteria of the genus Providencia are opportunistic pathogens of clinical significance due to their association with diarrhea and urinary tract infections. The present study was conducted to examine the prevalence and antimicrobial resistance of Providencia spp. in retail meats sold in Guangzhou, China and Osaka, Japan. Out of 158 meat samples including beef, pork and chicken, 67 Providencia (42%) belonging to four species viz., P.alcalifaciens, P. rustigianii, P. stuartii and P. rettgeri were isolated, and most of them were resistant to tetracycline (91%) followed by ampicillin (69%) and streptomycin (49%)...
March 19, 2018: Journal of Veterinary Medical Science
Luisa Flohr, Shaylene Beaudry, K Taneille Johnson, Nicholas West, Catherine M Burns, J Mark Ansermino, Guy A Dumont, David Wensley, Peter Skippen, Matthias Gorges
The pediatric intensive care unit (ICU) is a complex environment, in which a multidisciplinary team of clinicians (registered nurses, respiratory therapists, and physicians) continually observe and evaluate patient information. Data are provided by multiple, and often physically separated sources, cognitive workload is high, and team communication can be challenging. Our aim is to combine information from multiple monitoring and therapeutic devices in a mobile application, the VitalPAD , to improve the efficiency of clinical decision-making, communication, and thereby patient safety...
2018: IEEE Journal of Translational Engineering in Health and Medicine
Licia Colli, Marco Milanesi, Elia Vajana, Daniela Iamartino, Lorenzo Bomba, Francesco Puglisi, Marcello Del Corvo, Ezequiel L Nicolazzi, Sahar S E Ahmed, Jesus R V Herrera, Libertado Cruz, Shujun Zhang, Aixin Liang, Guohua Hua, Liguo Yang, Xingjie Hao, Fuyuan Zuo, Song-Jia Lai, Shuilian Wang, Ruyu Liu, Yundeng Gong, Mahdi Mokhber, Yongjiang Mao, Feng Guan, Augustin Vlaic, Bogdan Vlaic, Luigi Ramunno, Gianfranco Cosenza, Ali Ahmad, Ihsan Soysal, Emel Ö Ünal, Mariena Ketudat-Cairns, José F Garcia, Yuri T Utsunomiya, Pietro S Baruselli, Maria E J Amaral, Rangsun Parnpai, Marcela G Drummond, Peter Galbusera, James Burton, Eileen Hoal, Yulnawati Yusnizar, Cece Sumantri, Bianca Moioli, Alessio Valentini, Alessandra Stella, John L Williams, Paolo Ajmone-Marsan
The domestic water buffalo is native to the Asian continent but through historical migrations and recent importations, nowadays has a worldwide distribution. The two types of water buffalo, i.e., river and swamp, display distinct morphological and behavioral traits, different karyotypes and also have different purposes and geographical distributions. River buffaloes from Pakistan, Iran, Turkey, Egypt, Romania, Bulgaria, Italy, Mozambique, Brazil and Colombia, and swamp buffaloes from China, Thailand, Philippines, Indonesia and Brazil were genotyped with a species-specific medium-density 90K SNP panel...
2018: Frontiers in Genetics
Nina Bon, Giulia Frangi, Sophie Sourice, Jérôme Guicheux, Sarah Beck-Cormier, Laurent Beck
OBJECTIVE: The canonical role of the bone-derived fibroblast growth factor 23 (Fgf23) is to regulate the serum inorganic phosphate (Pi) level. As part of a feedback loop, serum Pi levels control Fgf23 secretion through undefined mechanisms. We recently showed in vitro that the two high-affinity Na+ -Pi co-transporters PiT1/Slc20a1 and PiT2/Slc20a2 were required for mediating Pi-dependent signaling. Here, we addressed the contribution of PiT1 and PiT2 to the regulation of Fgf23 secretion...
February 26, 2018: Molecular Metabolism
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"