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https://www.readbyqxmd.com/read/29152262/prosthetic-rehabilitation-of-edentulous-hemimandibulectomy-patient-a-clinical-report
#1
Shailendra Kumar Sahu, B K Motwani, Anurag Dani
Surgical resection of mandible causes deviation of mandible toward affected side, resulting in loss of occlusal contact. This article presents twin rows of nonanatomic teeth on the untreated side of maxillary complete denture. The palatal row helps in mastication, whereas the buccal row supports the cheeks and improves the aesthetics.
November 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29149358/clinically-directed-neuroimaging-of-ophthalmoplegia
#2
REVIEW
Lucia Danieli, Margherita Montali, Luca Remonda, Hanspeter E Killer, Cesare Colosimo, Alessandro Cianfoni
PURPOSE: Ophthalmoplegia (OP) can have numerous etiologies and different clinical presentations. Most causes of OP can be narrowed down to specific anatomical locations based on clinical information. The aim of this study was to outline the different categories of diseases encountered in patients with OP, based on the location along the ocular motor pathways, and the most appropriate imaging modality for the given scenarios. METHODS: Representative neuroimaging examples of pathological processes causing OP are displayed, sequenced by anatomical location and disease category...
November 17, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29146734/humanized-mice-in-studying-efficacy-and-mechanisms-of-pd-1-targeted-cancer-immunotherapy
#3
Minan Wang, Li-Chin Yao, Mingshan Cheng, Danying Cai, Jan Martinek, Chong-Xian Pan, Wei Shi, Ai-Hong Ma, Ralph W De Vere White, Susan Airhart, Edison T Liu, Jacques Banchereau, Michael A Brehm, Dale L Greiner, Leonard D Shultz, Karolina Palucka, James G Keck
Establishment of an in vivo small animal model of human tumor and human immune system interaction would enable preclinical investigations into the mechanisms underlying cancer immunotherapy. To this end, non-obese diabetic (NOD).Cg-Prkdc(scid)IL2rg(tm1Wjl) /Sz (null; NSG) mice were transplanted with human (h)CD34(+) hematopoietic progenitor and stem cells, which leads to the development of human hematopoietic and immune systems [humanized NSG (HuNSG)]. HuNSG mice received human leukocyte antigen partially matched tumor implants from patient-derived xenografts [PDX; nonsmall cell lung cancer (NSCLC), sarcoma, bladder cancer, and triple-negative breast cancer (TNBC)] or from a TNBC cell line-derived xenograft (CDX)...
November 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29144465/parallel-palaeogenomic-transects-reveal-complex-genetic-history-of-early-european-farmers
#4
Mark Lipson, Anna Szécsényi-Nagy, Swapan Mallick, Annamária Pósa, Balázs Stégmár, Victoria Keerl, Nadin Rohland, Kristin Stewardson, Matthew Ferry, Megan Michel, Jonas Oppenheimer, Nasreen Broomandkhoshbacht, Eadaoin Harney, Susanne Nordenfelt, Bastien Llamas, Balázs Gusztáv Mende, Kitti Köhler, Krisztián Oross, Mária Bondár, Tibor Marton, Anett Osztás, János Jakucs, Tibor Paluch, Ferenc Horváth, Piroska Csengeri, Judit Koós, Katalin Sebők, Alexandra Anders, Pál Raczky, Judit Regenye, Judit P Barna, Szilvia Fábián, Gábor Serlegi, Zoltán Toldi, Emese Gyöngyvér Nagy, János Dani, Erika Molnár, György Pálfi, László Márk, Béla Melegh, Zsolt Bánfai, László Domboróczki, Javier Fernández-Eraso, José Antonio Mujika-Alustiza, Carmen Alonso Fernández, Javier Jiménez Echevarría, Ruth Bollongino, Jörg Orschiedt, Kerstin Schierhold, Harald Meller, Alan Cooper, Joachim Burger, Eszter Bánffy, Kurt W Alt, Carles Lalueza-Fox, Wolfgang Haak, David Reich
Ancient DNA studies have established that Neolithic European populations were descended from Anatolian migrants who received a limited amount of admixture from resident hunter-gatherers. Many open questions remain, however, about the spatial and temporal dynamics of population interactions and admixture during the Neolithic period. Here we investigate the population dynamics of Neolithization across Europe using a high-resolution genome-wide ancient DNA dataset with a total of 180 samples, of which 130 are newly reported here, from the Neolithic and Chalcolithic periods of Hungary (6000-2900 bc, n = 100), Germany (5500-3000 bc, n = 42) and Spain (5500-2200 bc, n = 38)...
November 16, 2017: Nature
https://www.readbyqxmd.com/read/29140702/influence-of-the-carotenoid-composition-on-the-conformational-dynamics-of-photosynthetic-light-harvesting-complexes
#5
Marijonas Tutkus, Jevgenij Chmeliov, Danielis Rutkauskas, Alexander V Ruban, Leonas Valkunas
Non-photochemical quenching (NPQ) is the major self-regulatory mechanism of green plant, performed on a molecular level to protect them from an over-excitation during the direct sunlight. It is believed that NPQ becomes available due to conformational dynamics of the light-harvesting photosynthetic complexes and involves a direct participation of carotenoids. In this work, we perform a single-molecule microscopy on major light-harvesting complexes (LHCII) from different Arabidopsis thaliana mutants exhibiting various carotenoid composition...
November 21, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29138971/carbon-source-sink-relationship-in-arabidopsis-thaliana-the-role-of-sucrose-transporters
#6
Mickaël Durand, Dany Mainson, Benoît Porcheron, Laurence Maurousset, Rémi Lemoine, Nathalie Pourtau
The regulation of source-to-sink sucrose transport is associated with AtSUC and AtSWEET sucrose transporters' gene expression changes in plants grown hydroponically under different physiological conditions. Source-to-sink transport of sucrose is one of the major determinants of plant growth. Whole-plant carbohydrates' partitioning requires the specific activity of membrane sugar transporters. In Arabidopsis thaliana plants, two families of transporters are involved in sucrose transport: AtSUCs and AtSWEETs...
November 14, 2017: Planta
https://www.readbyqxmd.com/read/29135832/prognostic-value-of-the-persistence-of-c1q-binding-anti-hla-antibodies-in-acute-antibody-mediated-rejection-in-kidney-transplantation
#7
Elodie Bailly, Dany Anglicheau, Gilles Blancho, Philippe Gatault, Vincent Vuiblet, Valérie Chatelet, Emmanuel Morelon, Paolo Malvezzi, Anne Parissiadis, Jérôme Tourret, Gwendaline Guidicelli, Johnny Sayegh, Christiane Mousson, Philippe Grimbert, Isabelle Top, Moglie Le Quintrec, Raj Purgus, Pierre François Westeel, Barbara Proust, Valérie Chabot, Yvon Lebranchu, Frédéric Dehaut, Matthias Büchler
BACKGROUND: The differential pathogenicity of anti-HLA donor-specific antibodies (DSAs) is not fully understood. The presence of complement-binding DSAs help better defining the prognosis of acute antibody-mediated rejection (ABMR). The evolution of these antibodies after the treatment of ABMR is unknown. METHODS: We included patients from the French multicenter RITUX ERAH study diagnosed with acute antibody-mediated rejection (ABMR) within the first year of renal transplantation, with circulating anti-HLA DSAs and treated randomly by rituximab or placebo (and intravenous immunoglobulins, plasma exchange)...
November 13, 2017: Transplantation
https://www.readbyqxmd.com/read/29134651/heavy-metal-contamination-microbiological-spoilage-and-biogenic-amines-content-in-sushi-available-on-the-polish-market
#8
Piotr Kulawik, Dani Dordevic, Florian Gambuś, Katarzyna Szczurowska, Marzena Zając
BACKGROUND: The study determined the heavy metal contamination (mercury, cadmium, lead, arsenic and nickel) of nori, restaurant-served sushi and ready-to-eat sushi meals available through retail chains. Moreover the microbiological loads and biogenic amines content in ready-to-eat sushi meals were analysed. RESULTS: All the nori samples contained high levels of Cd (2.122 mg kg(-1) ), Ni (0.715 mg kg(-1) ), As (34.56 mg kg(-1) ) and Pb (0.659 mg kg(-1) ). The studied sushi samples contained high levels of Ni and Pb, reaching 0...
November 13, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29134013/southern-ocean-echinoids-database-an-updated-version-of-antarctic-sub-antarctic-and-cold-temperate-echinoid-database
#9
Salomé Fabri-Ruiz, Thomas Saucède, Bruno Danis, Bruno David
This database includes over 7,100 georeferenced occurrence records of sea urchins (Echinodermata: Echinoidea) obtained from samples collected in the Southern Ocean (+180°W/+180°E; -35°/-78°S) during oceanographic cruises led over 150 years, from 1872 to 2015. Echinoids are common organisms of Southern Ocean benthic communities. A total of 201 species is recorded, which display contrasting depth ranges and distribution patterns across austral provinces and bioregions. Echinoid species show various ecological traits including different nutrition and reproductive strategies...
2017: ZooKeys
https://www.readbyqxmd.com/read/29132368/frequency-of-canine-nt230-del4-mdr1-mutation-in-prone-pure-breeds-their-crosses-and-mongrels-in-israel-insights-from-a-worldwide-comparative-perspective
#10
Yaron Dekel, Yossy Machluf, Aviad Stoler, Arava Aderet, Daniel Baumel, Efrat Kellerman, Yoram Plotsky, Oshrat Noked Partouche, Gal Elhalal, Izhar Ben-Shlomo, Dani Bercovich
BACKGROUND: Sensitivity to macrocyclic lactones, which are commonly used in veterinary clinics, was first found in Rough Collies, and was attributed in 2001 to a 4 bp deletion in the MDR1 gene. The list of affected breeds currently includes 13 breeds. Researchers from different countries and continents examined the allelic frequencies of the nt230(del4) MDR1 mutation, emphasizing the clinical importance of this test not only to mutation-prone dogs, but also to their crosses and mongrels, since treatment of a deletion carrier with these compounds may lead to its death...
November 13, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29129395/echocardiographic-nomograms-for-upper-abdominal-aorta-doppler-systolic-wave-values-and-systo-diastolic-diameters-variations-in-children
#11
Massimiliano Cantinotti, Raffaele Giordano, Iuri Corsini, Carlo Dani, Marco Scalese, Bruno Murzi, Nadia Assanta, Isabella Spadoni, Sabrina Molinaro, Shelby Kutty, Giorgio Iervasi, Eliana Franchi
BACKGROUND: Abdominal aorta pulsatility and blood flow patterns are important diagnostic indicators in congenital heart disease. Reference values for these indexes are lacking. METHODS: We prospectively studied abdominal aorta pulsed-wave Doppler systolic peak velocity, deceleration time, and wave duration, and two-dimensional vessel diameters in systole and diastole in healthy Caucasian children. Heteroscedasticity was accounted for by White or Breusch-Pagan test...
November 9, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29128609/tracking-changes-in-spatial-frequency-sensitivity-during-natural-image-processing-in-school-age-an-event-related-potential-study
#12
Adrienn Aranka Rokszin, Dóra Győri-Dani, János Bácsi, László G Nyúl, Gábor Csifcsák
Several studies have shown that behavioral and electrophysiological correlates of processing visual images containing low or high spatial frequency (LSF or HSF) information undergo development after early childhood. However, the maturation of spatial frequency sensitivity during school age has been investigated using abstract stimuli only. The aim of the current study was to assess how LSF and HSF features affect the processing of everyday photographs at the behavioral and electrophysiological levels in children aged 7-15 years and adults...
February 2018: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29127365/the-primary-cilium-is-necessary-for-the-differentiation-and-the-maintenance-of-human-adipose-progenitors-into-myofibroblasts
#13
N Arrighi, K Lypovetska, C Moratal, S Giorgetti-Peraldi, C A Dechesne, C Dani, P Peraldi
The primary cilium is an organelle, present at the cell surface, with various biological functions. We, and others, have shown that it plays a role in the differentiation of adipose progenitors (APs) into adipocytes. APs can also differentiate into myofibroblasts when treated with TGF-β1. Several components of the TGF-β1 pathway are located within the cilium suggesting a function for this organelle in AP myofibrogenesis. We studied differentiation of APs into myofibroblasts in two human models: APs of the adipose tissue (aAPs) and APs resident in the skeletal muscles (mAPs)...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29126508/complications-in-children-with-ulcerative-colitis-undergoing-ileal-pouch-anal-anastomosis
#14
Dani O Gonzalez, Benedict C Nwomeh
Total colectomy with ileal pouch-anal anastomosis (IPAA) is considered the standard procedure for the surgical management of ulcerative colitis. Despite the widespread utility of the procedure, as many as 75% of patients who undergo IPAA, experience at least 1 complication. This review highlights difficult intraoperative scenarios and complications of pouch surgery in children, including intraoperative, postoperative, and functional complications. Intraoperative scenarios include insufficient mesenteric length and positive leak tests...
December 2017: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/29125513/effect-of-bladder-augmentation-on-vp-shunt-failure-rates-in-spina-bifida
#15
Dani O Gonzalez, Jennifer N Cooper, Daryl J McLeod
PURPOSE: Most patients with spina bifida require ventriculoperitoneal (VP) shunt placement. Some also require bladder augmentation, which may increase the risk of VP shunt malfunction and/or failure. The aim of this study was to assess whether bladder augmentation affects the rate of VP shunt failure in this population. METHODS: Using the Pediatric Health Information System, we studied patients with spina bifida born between 1992 and 2014 who underwent VP shunt placement...
October 20, 2017: Journal of Pediatric Rehabilitation Medicine
https://www.readbyqxmd.com/read/29122551/crispr-mediated-deletion-of-the-pecam-1-cytoplasmic-domain-increases-receptor-lateral-mobility-and-strengthens-endothelial-cell-junctional-integrity
#16
Danying Liao, Heng Mei, Yu Hu, Debra K Newman, Peter J Newman
AIMS: PECAM-1 is an abundant endothelial cell surface receptor that becomes highly enriched at endothelial cell-cell junctions, where it functions to mediate leukocyte transendothelial migration, sense changes in shear and flow, and maintain the vascular permeability barrier. Homophilic interactions mediated by the PECAM-1 extracellular domain are known to be required for PECAM-1 to perform these functions; however, much less is understood about the role of its cytoplasmic domain in these processes...
November 6, 2017: Life Sciences
https://www.readbyqxmd.com/read/29118739/resolving-species-level-changes-in-a-representative-soil-bacterial-community-using-microfluidic-quantitative-pcr
#17
Hannah Kleyer, Robin Tecon, Dani Or
Rapid advances in genome sequencing technologies enable determination of relative bacterial abundances and community composition, yet, changes at the species level remain difficult to detect despite importance for certain ecological inferences. We present a method for extraction and direct quantification of species composition of a predefined multispecies bacterial community using microfluidic-based quantitative real-time PCR (qPCR). We employ a nested PCR approach based on universal 16S rRNA gene pre-amplification followed by detection and quantification of absolute abundance of bacterial species using microfluidic array of parallel singleplex qPCR reactions...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29118387/flat-band-light-dynamics-in-stub-photonic-lattices
#18
Bastián Real, Camilo Cantillano, Dany López-González, Alexander Szameit, Masashi Aono, Makoto Naruse, Song-Ju Kim, Kai Wang, Rodrigo A Vicencio
We experimentally study a Stub photonic lattice and excite their localized linear states originated from an isolated Flat Band at the center of the linear spectrum. By exciting these modes in different regions of the lattice, we observe that they do not diffract across the system and remain well trapped after propagating along the crystal. By using their wave nature, we are able to combine - in phase and out of phase - two neighbor states into a coherent superposition. These observations allow us to propose a novel setup for performing three different all-optical logical operations such as OR, AND, and XOR, positioning Flat Band systems as key setups to perform all-optical operations at any level of power...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29115105/the-role-of-su-avr-in-tomorrow-s-practice-of-avr
#19
Dani Bitran, Shuli Silberman
Conventional Aortic Valve Replacemen (C-AVR) is the golden standard in the treatment of Severe Aortic Stenosis (AS). Despite its tremendous success there are many problems associated with the procedure. A large segment of the AS population is not suitable for surgery because of the excessive risk. In the last years Transcatheter Aortic Valve Implantation (TAVI) and the use of sutureless valves are new technologies that aim to replace the C-AVR. In this review we compare the three therapeutic modalities in treating severe AS...
November 7, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29113112/g2-m-phase-checkpoint-adaptation-and-micronuclei-formation-as-mechanisms-that-contribute-to-genomic-instability-in-human-cells
#20
REVIEW
Danî Kalsbeek, Roy M Golsteyn
One of the most common characteristics of cancer cells is genomic instability. Recent research has revealed that G2/M-phase checkpoint adaptation-entering mitosis with damaged DNA-contributes to genomic changes in experimental models. When cancer cells are treated with pharmacological concentrations of genotoxic agents, they undergo checkpoint adaptation; however, a small number of cells are able to survive and accumulate micronuclei. These micronuclei harbour damaged DNA, and are able to replicate and reincorporate their DNA into the main nucleus...
November 6, 2017: International Journal of Molecular Sciences
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