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https://www.readbyqxmd.com/read/29791923/inhaled-treprostinil-prodrug-lipid-nanoparticle-formulations-provide-long-acting-pulmonary-vasodilation
#1
Franziska G Leifer, Donna M Konicek, Kuan-Ju Chen, Adam J Plaunt, Dany Salvail, Charles E Laurent, Michel R Corboz, Zhili Li, Richard W Chapman, Walter R Perkins, Vladimir S Malinin
Treprostinil (TRE), a prostanoid analogue approved in the USA for the treatment of pulmonary arterial hypertension, requires continuous infusion or multiple dosing sessions per day for inhaled and oral routes of administration due to its short half-life. The inhaled drug is known to induce adverse systemic and local effects including headache, nausea, cough, and throat irritation which may be due at least in part to transiently high drug concentrations in the lungs and plasma immediately following administration [1]...
May 23, 2018: Drug Research
https://www.readbyqxmd.com/read/29790014/biochemical-profile-of-non-enzymatic-stress-markers-in-the-plant-species-urginea-maritima-in-a-mediterranean-natural-reserve-exposed-to-oxidative-stress
#2
Yara Khairallah, Tarek Houri, Bilal Osta, Dany Romanos, Georges Haddad
Protected areas decrease degrading natural ecosystems due to pollution such as air pollution. In 1981, the inhabitants founded Bentael natural reserve in Byblos, Lebanon, to secure their region against urbanization projects, like the recently constructed road that threatens the biodiversity of the reserve. This study was conducted to determine the oxidative stress resulting from this pollution and that menaces 360 floral species among them a rare species "Urginea maritima." In this research, the biomonitoring approach was experienced to assess the oxidative stress...
May 22, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29788446/differential-response-to-heat-stress-in-outer-and-inner-onion-bulb-scales
#3
Ortal Galsurker, Adi Doron-Faigenboim, Paula Teper-Bamnolker, Avinoam Daus, Amnon Lers, Dani Eshel
Brown protective skin formation in onion bulbs can be induced by rapid postharvest heat treatment. Onions that were peeled to different depths and were exposed to heat stress showed that only the outer scale formed dry brown skin, whereas the inner scales maintained high water content and did not change color. Our results reveal that browning of the outer scale during heat treatment is due to an enzymatic process that is associated with high levels of oxidation components, such as peroxidase and quercetin glucoside...
May 18, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29785627/chemical-communication-and-reproduction-partitioning-in-social-wasps
#4
REVIEW
Francesca Romana Dani, Stefano Turillazzi
Social wasps encompass species displaying diverse social organization regarding colony cycle, nest foundation, caste differences (from none to significant dimorphism) and number of reproductive queens. Current phylogenetic data suggests that sociality occured independently in the subfamily Stenogastrinae and in the Polistinae+Vespinae clade. In most species, including those with the simplest social organization, colony reproduction is monopolised by a single or few females. Since their nest mates can also develop ovaries and lay eggs, dominant females must somehow inhibit them from reproducing...
May 22, 2018: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/29785062/outcomes-of-hypoxic-respiratory-failure-at-birth-associated-with-previable-rupture-of-membranes
#5
Michelle Baczynski, Shannon Ginty, Dany Weisz, Patrick J McNamara, Edmond Kelly, Prakesh S Shah, Amish Jain
OBJECTIVE: To characterize clinical outcomes of infants born after previable rupture of membranes (pROM, < 23 weeks gestation and latency period ≥ 2 weeks) in relation to refractory hypoxic respiratory failure (rHRF). STUDY DESIGN: pROM neonates categorized as rHRF (FiO2  > 0.6 for ≥ 2 h) and treated (high frequency ventilation + inhaled nitric oxide) were compared with no rHRF group. Primary outcome was survival until discharge. Factors associated with rHRF and mortality were identified...
May 22, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29785061/targeted-neonatal-echocardiography-tne-consult-service-in-a-large-tertiary-perinatal-center-in-canada
#6
Ismina Papadhima, Deepak Louis, Jyotsna Purna, Poorva Deshpande, Yenge Diambomba, Shoo Lee, Prakesh Shah, Dany Weisz, Afif El-Khuffash, Patrick J McNamara, Luc Mertens, Amish Jain
OBJECTIVE: To describe the utilization and study the factors associated with the impact on clinical management of a new TNE consultation service in a perinatal center. METHODS: This retrospective cohort study included all neonates who underwent TNE consultation at the neonatal unit of Mount Sinai Hospital in Toronto, Canada (November 2011 and July 2015). The consults that had "impact" were defined as those that led to a TNE suggested change in the clinical management within 6 h of its recommendation...
May 22, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29784215/emotional-labour-of-caregivers-confronted-with-aggressive-brain-injured-patients
#7
Magali Huet, Lionel Dany, Thémistoklis Apostolidis
BACKGROUND: Aggressive behaviours are common with people who have suffered brain injuries and induce difficult emotions among certified nursing assistants and medical-psychological assistants who take care of them. These caregivers carry out emotional labour whose content and strategies are little known. AIM: The study explores the emotional labour of certified nursing assistants and medical-psychological assistants faced with the aggressive behaviours of brain-injured patients...
June 2018: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/29782705/wild-gwas-association-mapping-in-natural-populations
#8
Anna W Santure, Dany Garant
The increasing affordability of sequencing and genotyping technologies has transformed the field of molecular ecology in recent decades. By correlating marker variants with trait variation using association analysis, large-scale genotyping and phenotyping of individuals from wild populations has enabled the identification of genomic regions that contribute to phenotypic differences among individuals. Such 'gene mapping' studies are enabling us to better predict evolutionary potential and the ability of populations to adapt to challenges, such as changing environment...
May 21, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29779148/in-vitro-virulence-characteristics-of-rare-serovars-of-salmonella-enterica-isolated-from-sand-lizards-lacerta-agilis-l
#9
Joanna Mokracka, Sylwia Krzymińska, Danił Ałtunin, Dariusz Wasyl, Ryszard Koczura, Krzysztof Dudek, Monika Dudek, Zofia Anna Chyleńska, Anna Ekner-Grzyb
The aim of this study was to estimate virulence potential of Salmonella enterica strains colonizing the gut of free-living sand lizards (Lacerta agilis L.). The strains belonged to three Salmonella serovars: Abony, Schleissheim, and Telhashomer. Adhesion and invasion abilities of the strains were determined in quantitative assays using the gentamicin protection method. Induction of apoptosis was assessed using HeLa cell monolayers. PCR assays were used for detection of 26 virulence genes localised within mobile elements: pathogenicity islands, virulence plasmids, and prophage sequences...
May 19, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29776707/unplanned-extubations-in-an-intensive-care-unit-findings-from-a-critical-incident-technique
#10
Matteo Danielis, Simona Chiaruttini, Alvisa Palese
BACKGROUND: Patients on mechanical ventilation are at risk of experiencing a potentially life-threatening unplanned extubation in the intensive care unit, which can lead to arrhythmias, bronchial aspiration, difficulty in reintubation or even sudden cardiac arrest. Although incidence and outcomes of the phenomenon have been documented in several quantitative studies, no studies have investigated the antecedents as experienced by critical care nurses. OBJECTIVES: To gain a greater understanding of the antecedents of unplanned extubations...
May 15, 2018: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/29775364/rapid-neutrino-cooling-in-the-neutron-star-mxb-1659-29
#11
Edward F Brown, Andrew Cumming, Farrukh J Fattoyev, C J Horowitz, Dany Page, Sanjay Reddy
We show that the neutron star in the transient system MXB 1659-29 has a core neutrino luminosity that substantially exceeds that of the modified Urca reactions (i.e., n+n→n+p+e^{-}+ν[over ¯]_{e} and inverse) and is consistent with the direct Urca (n→p+e^{-}+ν[over ¯]_{e} and inverse) reaction occurring in a small fraction of the core. Observations of the thermal relaxation of the neutron star crust following 2.5 yr of accretion allow us to measure the energy deposited into the core during accretion, which is then reradiated as neutrinos, and infer the core temperature...
May 4, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29775355/weakly-nonergodic-dynamics-in-the-gross-pitaevskii-lattice
#12
Thudiyangal Mithun, Yagmur Kati, Carlo Danieli, Sergej Flach
The microcanonical Gross-Pitaevskii (also known as the semiclassical Bose-Hubbard) lattice model dynamics is characterized by a pair of energy and norm densities. The grand canonical Gibbs distribution fails to describe a part of the density space, due to the boundedness of its kinetic energy spectrum. We define Poincaré equilibrium manifolds and compute the statistics of microcanonical excursion times off them. The tails of the distribution functions quantify the proximity of the many-body dynamics to a weakly nonergodic phase, which occurs when the average excursion time is infinite...
May 4, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29771204/past-present-and-future-challenges-in-health-care-priority-setting
#13
William Hall, Iestyn Williams, Neale Smith, Marthe Gold, Joanna Coast, Lydia Kapiriri, M Danis, Craig Mitton
Purpose Current conditions have intensified the need for health systems to engage in the difficult task of priority setting. As the search for a "magic bullet" is replaced by an appreciation for the interplay between evidence, interests, culture, and outcomes, progress in relation to these dimensions requires assessment of achievements to date and identification of areas where knowledge and practice require attention most urgently. The paper aims to discuss these issues. Design/methodology/approach An international survey was administered to experts in the area of priority setting...
May 21, 2018: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/29768941/bilirubin-and-oxidative-stress-in-term-and-preterm-infants
#14
Carlo Dani, Chiara Poggi, Simone Pratesi
Hyperbilirubinemia is the most frequent clinical problem neonatologists must deal with during the newborn period. It has been suggested that bilirubin is involved in the balance between antioxidant and pro-oxidant agents due to its antioxidant properties. However, the relevance of these effects in vivo in term and preterm infants is still debated. We performed a literature review of studies that investigated the association between total serum bilirubin (TSB) and oxidative stress in newborn infants. We found that studies in term infants give contradictory results, while studies in preterm infants suggest that the TSB increase is associated with an oxidative stress increase due to concurrent factors other than bilirubin level, such as heme oxygenase (HO) activity...
May 16, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29764527/an-outbreak-of-haemorrhagic-fever-with-renal-syndrome-linked-with-mountain-recreational-activities-in-zagreb-croatia-2017
#15
Z Lovrić, B Kolarić, M L Kosanović Ličina, M Tomljenović, O Đaković Rode, K Danis, B Kaić, V Tešić
In 2017 Zagreb faced the largest outbreak of haemorrhagic fever with renal syndrome (HFRS) to date. We investigated to describe the extent of the outbreak and identify risk factors for infection. We compared laboratory-confirmed cases of Hantavirus infection in Zagreb residents with the onset of illness after 1 January 2017, with individually matched controls from the same household or neighbourhood. We calculated adjusted matched odds ratios (amOR) using conditional logistic regression. During 2017, 104 cases were reported: 11-81 years old (median 37) and 71% (73) male...
May 16, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29762744/forensically-relevant-blow-flies-in-lebanon-survey-and-identification-using-molecular-markers-diptera-calliphoridae
#16
Salman Shayya, Régis Debruyne, André Nel, Dany Azar
Calliphoridae are among the first insects associated to decomposing animal remains. We have collected 1,841 specimens of three calliphorid genera: Calliphora, Lucilia, and Chrysomya, from different Lebanese localities as a first step in implementing a database of insects of forensic relevance for the country. Blow-flies are crucial for the estimation of the postmortem interval. DNA-based identification is a rapid and accurate method, often used for morphologically similar species, especially for immatures or incomplete specimens...
May 12, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29761912/proteinase-pattern-of-honeybee-prepupae-from-healthy-and-american-foulbrood-infected-bees-investigated-by-zymography-the-numbered-spots-figure-4-were-excised-from-the-gels-and-they-were-individually-transferred-to-a-1-5-ml-microcentrifuge-tube-spots-were-destained
#17
Proteinase pattern of honeybee prepupae from healthy and American Foulbrood infected bees investigated by zymography: The numbered spots (figure 4) were excised from the gels and they were individually transferred to a 1.5 mL microcentrifuge tube. Spots were destained and proteins digested as reported by Dani et al. 40. Each peptide mixture was submitted to capillary-LC-μESI-MS/MS analysis on an Ultimate 3000 HPLC (Dionex, San Donato Milanese, Milano, Italy) coupled to a LTQ Orbitrap mass spectrometer (Thermo Fisher, Bremen, Germany). Peptides were concentrated on a precolumn cartridge PepMap100 C18 (300 μm i.d. × 5 mm, 5 μm, 100 Å, LC Packings Dionex) and then eluted on a homemade capillary column packed with Aeris Peptide XB-C18 phase (180 μm i.d. × 15 cm, 3.6 μm, 100 Å, Phenomenex, Torrance, CA, USA) at 1 μl/min. The loading mobile phases were: 0.1% TFA in H 2 O (phase A) and 0.1% TFA in CH 3 CN (phase B). The elution mobile phases composition was: H 2 O 0.1% formic acid/CH 3 CN 97/3 (phase A) and CH 3 CN 0.1% formic acid/ H 2 O 97/3 (phase B). The elution program was: 0 min, 4% B; 10 min, 40% B; 30 min, 65% B; 35 min, 65% B; 36 min, 90% B; 40 min, 90% B; 41 min, 4%B; 60 min, 4% B. Mass spectra were acquired in positive ion mode, setting the spray voltage at 1.8 kV, the capillary voltage and temperature respectively at 45 V and 200°C, and the tube lens at 130 V. Data were acquired in data-dependent mode with dynamic exclusion enabled (repeat count 2, repeat duration 15 s, exclusion duration 30 s); survey MS scans were recorded in the Orbitrap analyzer in the mass range 300-2000 m/z at a 15,000 nominal resolution at m/z = 400; then up to three most intense ions in each full MS scan were fragmented (isolation width 3 m/z, normalized collision energy 30) and analyzed in the IT analyzer. Monocharged ions did not trigger MS/MS experiments.
Antonio Felicioli, Barbara Turchi, Filippo Fratini, Matteo Giusti, Roberta Nuvoloni, Francesca Romana Dani, Simona Sagona
American foulbrood disease (AFB) is the main devastating disease that affects honeybees' brood, caused by Paenibacillus larvae. The trend of the research on AFB has addressed the mechanisms by which P. larvae bacteria kill honeybee larvae. Since prepupae could react to the infection of AFB by increasing protease synthesis, the aim of this work was to compare protease activity in worker prepupae belonging to healthy colonies and to colonies affected by AFB. This investigation was performed by zymography. In gel, proteolytic activity was observed in prepupae extracts belonging to the healthy colonies...
May 15, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29759484/runt-related-transcription-factor-1-runx1-promotes-tgf-%C3%AE-induced-renal-tubular-epithelial-to-mesenchymal-transition-emt-and-renal-fibrosis-through-the-pi3k-subunit-p110%C3%AE
#18
Tong Zhou, Maocai Luo, Wei Cai, Siyuan Zhou, Danying Feng, Chundi Xu, Hongyan Wang
Renal fibrosis is widely considered a common mechanism leading to end-stage renal failure. Epithelial-to-mesenchymal transition (EMT) plays important roles in the pathogenesis of renal fibrosis. Runt-related transcription factor 1(RUNX1) plays a vital role in hematopoiesis via Endothelial-to-Hematopoietic Transition (EHT), a process that is conceptually similar to EMT, but its role in EMT and renal fibrosis is unclear. Here, we demonstrate that RUNX1 is overexpressed in the processes of TGF-β-induced partial EMT and renal fibrosis and that the expression level of RUNX1 is SMAD3-dependent...
May 11, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29756773/combined-spectroelectrochemical-and-simulated-insights-into-the-electrogenerated-chemiluminescence-coreactant-mechanism
#19
Andrew Scott Danis, Karlie Paige Potts, Samuel Charles Perry, Janine Mauzeroll
Electrogenerated chemiluminescence (ECL) based sensors have the intrinsic advantage of having zero theoretical background signal, derived from the electrochemical initiation of the luminescence process. Since the limit of detection (LOD) for sensors is defined as three times the noise of the background over the sensitivity of the system, further improvement to an ECL based detection limit is tied to improving sensitivity. Enhancing ECL sensitivity can be achieved through optimizing the mechanistic or kinetic performance of the reagents...
May 14, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29754322/continuity-of-learning-in-discontinuous-conditions-children-experience-of-transition-in-irreversible-time
#20
Dany Boulanger
In this theoretical paper, I propose that in certain conditions children's subjective continuity (irreversible time) of experience could be sustained by objective discontinuity in reference to instruments like the clock that is used to sequentialize time in school. I suggest that it happens through intervals-as-transitions (c.f., breaks in school) that Min (2018; this special issue) undermines for epistemological reasons but insisted upon by Bergson. I use Bergson to epistemologically reframe Min's (2018) interesting suggestions -that I partially use- with respect to irreversible time...
May 12, 2018: Integrative Psychological & Behavioral Science
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