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https://www.readbyqxmd.com/read/28212119/the-role-of-biomarkers-in-undiagnosed-men
#1
Hasan Dani, Stacy Loeb
PURPOSE OF REVIEW: This article intends to review biomarkers derived from blood, urine, and tissue that can aid in the diagnosis of prostate cancer (PCa). RECENT FINDINGS: PCa screening requires tools that complement prostate-specific antigen (PSA) with a higher specificity for clinically significant disease. Novel blood biomarkers, such as the Prostate Health Index (phi) and 4Kscore, utilize isoforms of PSA to more accurately predict high-grade PCa than traditional tools such as PSA and the percentage free-to-total PSA...
February 16, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28209550/pathogenicity-of-mexican-isolates-of-aeromonas-sp-in-immersion-experimentally-infected-rainbow-trout-oncorhynchus-mykiss-walbaum-1792
#2
Andrea Paloma Zepeda-Velázquez, Vicente Vega-Sánchez, César Ortega-Santana, Miguel Rubio-Godoy, Dany Montes de Oca-Mira, Edgardo Soriano-Vargas
Ten species of Aeromonas have been previously identified in farmed rainbow trout from Mexico. The aim of the current study was to investigate the pathogenicity of 10 Aeromonas isolates belonging to 10 different Aeromonas species in immersion experimentally-infected rainbow trout fry. Isolates of A. bestiarum, A. hydrophila, A. salmonicida, and A. veronii produced significant mortality (8.8%, 12.2%, 18.8%, and 8.8%, respectively). Isolates of A. caviae and A. sobria produced no significantly mortality (3.3% and 1...
February 13, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28207947/association-and-expression-of-antigen-processing-gene-psmb8-coding-for-low-molecular-mass-protease-7-lmp7-with-vitiligo-in-north-india-case-control-study
#3
P Dani, N Patnaik, A Singh, A Jaiswal, B Agrawal, A A Kumar, S R Varkhande, A Sharma, U Vaish, P Ghosh, V K Sharma, P Sharma, G Verma, H K Kar, S Gupta, V T Natarajan, R S Gokhale, R Rani
BACKGROUND: Vitiligo is a multifactorial, autoimmune, depigmenting disorder of the skin where aberrant presentation of auto antigens may have a role to play. OBJECTIVES: To study the association of antigen processing genes, PSMB8 and PSMB9 with vitiligo. METHODS: 1320 vitiligo cases (1050 generalized and 270 localized) and 752 normal healthy controls were studied for PSMB9 exon 3 G/A SNP, PSMB8 exon 2 C/A SNP and PSMB8 Intron 6 G/T at 37360 site using PCR-RFLP...
February 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28193568/markers-of-iron-deficiency-in-patients-with-polycythemia-vera-receiving-ruxolitinib-or-best-available-therapy
#4
Srdan Verstovsek, Claire N Harrison, Jean-Jacques Kiladjian, Carole Miller, Ahmad B Naim, Dilan C Paranagama, Dany Habr, Alessandro M Vannucchi
Polycythemia vera (PV) is characterized by erythropoiesis and JAK2-activating mutations, with increased risks of morbidity and mortality. Most patients with PV are iron deficient, and treatment often includes hematocrit control with phlebotomy, which may exacerbate iron deficiency-associated complications. The phase 3 RESPONSE trial evaluated the JAK1/JAK2 inhibitor ruxolitinib (n=110) versus best available therapy (BAT; n=112) in patients with PV who were hydroxyurea-resistant/intolerant. Ruxolitinib was superior to BAT for hematocrit control, reduction in splenomegaly, and blood count normalization...
January 31, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28186828/is-the-muscle-the-only-potential-target-of-desipramine-in-obstructive-sleep-apnea-syndrome
#5
Dany Jaffuel, Jean-Pierre Mallet, Yves Dauvilliers, Arnaud Bourdin
No abstract text is available yet for this article.
February 10, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28186244/patterns-of-diversity-and-spatial-variability-of-%C3%AE-defensin-innate-immune-genes-in-a-declining-wild-population-of-tree-swallows
#6
Clarence Schmitt, Dany Garant, Kathy Doyon, Nicolas Bousquet, Luc Gaudreau, Marc Bélisle, Fanie Pelletier
No abstract text is available yet for this article.
February 10, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/28164330/quality-of-life-in-patients-with-genetic-neuromuscular-disease-questionnaire-rasch-validation-of-the-french-version-qol-gnmd
#7
Antoine Dany, Amandine Rapin, Brice Lavrard, Virginie Saoût, Christian Réveillère, Guillaume Bassez, Vincent Tiffreau, Yann Péréon, Sabrina Sacconi, Bruno Eymard, Moustapha Dramé, Damien Jolly, Jean-Luc Novella, Jean-Benoit Hardouin, François C Boyer
INTRODUCTION: Slowly-progressive, genetic neuromuscular diseases (gNMDs) often lead to important motor deficiencies and functional limitations. The QoL-gNMD is a new health-related quality of life questionnaire developed for these patients. The purpose of the present study was to validate the French version of the QoL-gNMD and to calibrate its measurement system. METHODS: Both the QoL-gNMD and a validated generic questionnaire (WHOQOL-BREF) were administered to patients...
February 6, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28160765/the-use-of-complementary-and-alternative-medicine-among-dialysis-patients
#8
Ronit Koren, Hadas Zafrir Danieli, Keren Doenyas-Barak, Tomer Ziv-Baran, Ahuva Golik
Context • The use of complementary and alternative medicine (CAM) has been on the rise in the last decade. Subpopulations of patients with chronic diseases are at risk for adverse events and potential drug-herb interactions, among them dialysis patients. Objective • The study aimed to evaluate the prevalence of CAM consumption among dialysis patients and to search for potential interactions. Design • The study was cross-sectional, based on questionnaires. Setting • The study occurred in the hemodialysis unit at Assaf Harofeh Medical Center (Zeriffin, Israel)...
January 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28158382/profile-of-tuberculous-cervical-lymphadenopathy-in-children
#9
Ira Shah, Samruddhi Dani
No abstract text is available yet for this article.
February 1, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28157201/longitudinal-in-vivo-bioimaging-of-hepatocyte-transcription-factor-activity-following-cholestatic-liver-injury-in-mice
#10
Juliette M K M Delhove, Suzanne M K Buckley, Dany P Perocheau, Rajvinder Karda, Patrick Arbuthnot, Neil C Henderson, Simon N Waddington, Tristan R McKay
Molecular mechanisms regulating liver repair following cholestatic injury remain largely unknown. We have combined a mouse model of acute cholestatic liver injury, partial bile duct ligation (pBDL), with a novel longitudinal bioimaging methodology to quantify transcription factor activity during hepatic injury and repair. We administered lentiviral transcription factor activated luciferase/eGFP reporter (TFAR) cassettes to neonatal mice enabling longitudinal TFAR profiling by continued bioimaging throughout the lives of the animals and following pBDL in adulthood...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28155732/-video-games-internet-and-social-networks-160-a-study-among-french-school-students
#11
Lionel Dany, Laure Moreau, Clémentine Guillet, Carmelo Franchina
Differences in the use of video games or social networks raise the general issue of gender differences in society. This study indicates the need for more specific preventive interventions for screen-based media use. The addictive “nature” of certain practices needs to be studied in more detail.</ce:para>.
November 25, 2016: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/28155282/phonemic-awareness-of-english-second-language-learners
#12
Maria Le Roux, Salome Geertsema, Heila Jordaan, Danie Prinsloo
BACKGROUND: The PA skills of phonological blending and segmentation and auditory word discrimination relate directly to literacy and may be weak in English second language (EL2) learners. In South Africa, literacy skills have been found to be poor in especially EL2 learners. OBJECTIVES: The purpose of this paper is to determine the effects of vowel perception and production intervention on phonemic awareness (PA) and literacy skills of Setswana first language (L1) learners...
January 30, 2017: South African Journal of Communication Disorders. die Suid-Afrikaanse Tydskrif Vir Kommunikasieafwykings
https://www.readbyqxmd.com/read/28153209/a-place-for-apnea-hypopnea-index-telemonitoring-in-preventing-heart-failure-exacerbation
#13
Alain Palot, Dany Jaffuel, Marion Gouitaa, Céline Tummino, Denis Charpin, Pascal Chanez
No abstract text is available yet for this article.
January 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28152942/communities-of-practice-a-jurisdictional-approach-to-improving-the-quality-of-care-in-radiation-medicine-in-ontario
#14
Michelle Ang, Lindsay Elizabeth Reddeman, Michael Sharpe, Margaret Hart, Carina Simniceanu, Stephen Breen, Joon-Hyung J Kim, Dani Scott, Khaled Zaza, David D'Souza, Michael F Milosevic, Stewart Gaede, Andrea Marshall, Brian P Yaremko, Katharina Sixel, Nicole Harnett, Eric Gutierrez, Padraig Richard Warde
: 122 Background: The Radiation Treatment Program (RTP) at Cancer Care Ontario (CCO) established several Communities of Practice (CoPs), with the goal of improving radiation treatment (RT) quality and safety. The RTP identifies variation in practice and quality improvement (QI) opportunities in the 14 Regional Cancer Centres (RCCs) and facilitates the development of CoPs to share best practices and standardize care. METHODS: Since 2010, the RTP has formed 7 CoPs ( > 185 members in total): 4 intra-disciplinary (Radiation Therapy, Medical Physics, Advanced Practice Radiation Therapy, Radiation Safety) and 3 inter-disciplinary (Head and Neck (HN), Gynecological (GYNE) and Lung Cancer)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28149920/hybrid-positron-emission-tomography-segmentation-of-heterogeneous-lung-tumors-using-3d-slicer-improved-growcut-algorithm-with-threshold-initialization
#15
Hannah Mary T Thomas, Devadhas Devakumar, Balukrishna Sasidharan, Stephen R Bowen, Danie Kingslin Heck, E James Jebaseelan Samuel
This paper presents an improved GrowCut (IGC), a positron emission tomography-based segmentation algorithm, and tests its clinical applicability. Contrary to the traditional method that requires the user to provide the initial seeds, the IGC algorithm starts with a threshold-based estimate of the tumor and a three-dimensional morphologically grown shell around the tumor as the foreground and background seeds, respectively. The repeatability of IGC from the same observer at multiple time points was compared with the traditional GrowCut algorithm...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28146549/phase-retrieval-in-multicore-fiber-bundles
#16
Dani Kogan, Siddharth Sivankutty, Viktor Tsvirkun, Géraud Bouwmans, Esben Ravn Andresen, Hervé Rigneault, Dan Oron
Multicore fiber bundles are widely used in endoscopy due to their miniature size and their direct imaging capabilities. They have recently been used, in combination with spatial light modulators, in various realizations of endoscopy with little or no optics at the distal end. These schemes require characterization of the relative phase offsets between the different cores, typically done using off-axis holography, thus requiring both an interferometric setup and, typically, access to the distal tip. Here we explore the possibility of employing phase retrieval to extract the necessary phase information...
February 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28145917/barriers-to-pelvic-floor-physical-therapy-regarding-treatment-of-high-tone-pelvic-floor-dysfunction
#17
Dani Zoorob, Margaret Higgins, Kimberly Swan, Jennifer Cummings, Sarah Dominguez, Erin Carey
OBJECTIVE: Chronic pelvic pain is a prevalent and debilitating condition with a wide range of etiologies. An estimated 30% to 70% of chronic pelvic cases involve musculoskeletal component pain including high-tone pelvic floor dysfunction (HTPFD). Pelvic floor physical therapy has been shown to be a beneficial treatment for HTPFD, yet many patients do not have access to this treatment. The objective of this study was to identify the barriers preventing patients from following through with the first-line management, physical therapy...
January 31, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28138956/why-were-sardinians-the-shortest-europeans-a-journey-through-genes-infections-nutrition-and-sex
#18
Giovanni Mario Pes, Eugenia Tognotti, Michel Poulain, Dany Chambre, Maria Pina Dore
Since ancient times the Mediterranean island of Sardinia has been known for harboring a population with an average body height shorter than almost every other ethnic group in Europe. After over a century of investigations, the cause(s) at the origin of this uniqueness are not yet clear. The shorter stature of Sardinians appears to have been documented since prehistoric times, as revealed by the analysis of skeletal remains discovered in archaeological sites on the island. Recently, a number of genetic, hormonal, environmental, infective and nutritional factors have been put forward to explain this unique anthropometric feature, which persisted for a long time, even when environmental and living conditions improved around 1960...
January 31, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28137317/high-added-value-of-a-population-based-participatory-surveillance-system-for-community-acute-gastrointestinal-respiratory-and-influenza-like-illnesses-in-sweden-2013-2014-using-the-web
#19
A Pini, H Merk, A Carnahan, I Galanis, E VAN Straten, K Danis, M Edelstein, A Wallensten
In 2013-2014, the Public Health Agency of Sweden developed a web-based participatory surveillance system, Hӓlsorapport, based on a random sample of individuals reporting symptoms weekly online, to estimate the community incidence of self-reported acute gastrointestinal (AGI), acute respiratory (ARI) and influenza-like (ILI) illnesses and their severity. We evaluated Hӓlsorapport's acceptability, completeness, representativeness and its data correlation with other surveillance data. We calculated response proportions and Spearman correlation coefficients (r) between (i) incidence of illnesses in Hӓlsorapport and (ii) proportions of specific search terms to medical-advice website and reasons for calling a medical advice hotline...
January 31, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28129809/applying-cystic-fibrosis-transmembrane-conductance-regulator-genetics-and-cftr2-data-to-facilitate-diagnoses
#20
Patrick R Sosnay, Danieli B Salinas, Terry B White, Clement L Ren, Philip M Farrell, Karen S Raraigh, Emmanuelle Girodon, Carlo Castellani
OBJECTIVE: As a Mendelian disease, genetics plays an integral role in the diagnosis of cystic fibrosis (CF). The identification of 2 disease-causing mutations in the CF transmembrane conductance regulator (CFTR) in an individual with a phenotype provides evidence that the disease is CF. However, not all variations in CFTR always result in CF. Therefore, for CFTR genotype to provide the same level of evidence of CFTR dysfunction as shown by direct tests such as sweat chloride or nasal potential difference, the mutations identified must be known to always result in CF...
February 2017: Journal of Pediatrics
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