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Nuray Tuloglu, Sule Bayrak, Emine Sen Tunc, Fusun Ozer
BACKGROUND: This study aimed to investigate the effects of a fluoride varnish with added Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) treatments on acid resistance of primary teeth enamel. METHODS: Enamel specimens obtained from 40 primary incisors (for surface microhardness testing) and 40 primary molars (for demineralization depth measurement) were randomly divided into four groups (n = 10 incisors and 10 molars) each according to surface treatment: no treatment (control), MI varnish (1-8 % sodium fluoride and 1-5 % CPP-ACP), Clinpro White (1-5 % sodium fluoride and <5 % modified tricalcium phosphate), Duraphat (<5 % sodium fluoride)...
2016: BMC Oral Health
Katarzyna Fita, Urszula Kaczmarek
BACKGROUND: Some fluoridated toothpastes, available commercially, are described to have a protective effect against dental erosion. OBJECTIVES: To evaluate the influence of the selected marketed toothpastes on the human enamel exposed to acid beverages. MATERIAL AND METHODS: Enamel specimens from extracted human teeth were prepared (n = 40). Specimens were randomly divided into 10 experimental groups, 4 specimens each, which were subjected to acid challenge for 10 min using orange juice (pH 3...
March 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Meghna Bajaj, P Poornima, S Praveen, N B Nagaveni, K B Roopa, I E Neena, K P Bharath
OBJECTIVES: To compare CPP-ACP, Tri-calcium phosphate and Hydroxyapatite on remineralization of artificial caries like lesions on primary enamel. STUDY DESIGN: Ten extracted Primary molars coated with nail varnish, leaving a window of 2×4 mm on buccal and lingual surface were immersed in demineralizing solution for 96 hours and sectioned longitudinally to obtain 40 sections (4 sections per tooth) and were randomly divided into 4 groups (A to D) n=10; Group A: negative control, Group B: CPP-ACP, Group C: Tri-calcium phosphate, Group D: Hydroxyapatite...
2016: Journal of Clinical Pediatric Dentistry
Jennifer O Simmons, Erik J Meyers, Wen Lien, Rosalia L Banfield, Howard W Roberts, Kraig S Vandewalle
OBJECTIVES: The purpose of this study was to evaluate the effect of various surface treatments on the mechanical properties and antibacterial activity of desiccated glass-ionomer (GI) and resin-modified glass-ionomer (RMGI) materials. METHODS: One hundred GI and RMGI specimens were fabricated in a mold, stored in 100% humidity for 24h, placed in air to desiccate for 24h, and then stored for one week in one of the five media [casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), chlorhexidine (CHX), sodium fluoride (NaF), cetylpyridinium chloride (CPC), or 100% humidity (control)]...
September 6, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Stuart G Dashper, Deanne V Catmull, Sze-Wei Liu, Helen Myroforidis, Ilya Zalizniak, Joseph E A Palamara, N Laila Huq, Eric C Reynolds
Glass ionomer cements (GIC) are dental restorative materials that are suitable for modification to help prevent dental plaque (biofilm) formation. The aim of this study was to determine the effects of incorporating casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) into a GIC on the colonisation and establishment of Streptococcus mutans biofilms and the effects of aqueous CPP-ACP on established S mutans biofilms. S. mutans biofilms were either established in flow cells before a single ten min exposure to 1% w/v CPP-ACP treatment or cultured in static wells or flow cells with either GIC or GIC containing 3% w/w CPP-ACP as the substratum...
2016: PloS One
Amira N Fadl, Magda M ElTekeya, Karin L Dowidar, Nadia Mokhles, Maha M El Tantawi
PURPOSE: Control of Streptococcus mutans can prevent caries in high-risk preschool children. The purpose of this study was to assess the effect of casein phosphopeptide amorphous calcium phosphate (CPP-ACP) on Streptococcus mutans in the plaque of high-risk preschool children. METHODS: A triple blind, randomized, controlled clinical trial included 40 healthy three- to five-year-olds with at least one white spot lesion. They were randomized into test (daily applications of GC Tooth Mousse:CPP-ACP) and control groups (placebo mousse)...
2016: Pediatric Dentistry
Krunal Chokshi, Achala Chokshi, Sapna Konde, Sunil Raj Shetty, Kumar Narayan Chandra, Sinjana Jana, Sanjana Mhambrey, Sneha Thakur
INTRODUCTION: The caries process has been thought to be irreversible, resulting in the permanent loss of tooth substance and eventually the development of a cavity. Recent approaches focused on application of remineralizing agents to incipient carious lesions, aim at controlling demineralization and promoting remineralization. Remineralizing agents create a supersaturated environment around the lesion; thus, preventing mineral loss and forces calcium and phosphate ions in the vacant areas...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
Deepti Munjal, Shalini Garg, Abhishek Dhindsa, Gagandeep Kaur Sidhu, Harsimran Singh Sethi
INTRODUCTION: As hindrance of remineralisation process occurs during orthodontic therapy resulting in decalcification of enamel because number of plaque retention sites increases due to banding and bonding of appliances to teeth. AIM: The present analytic study was undertaken to assess the occurrence of white spot lesions in permanent molars of children with and without orthodontic therapy and to evaluate the effect of Casein PhosphoPeptide-Amorphous Calcium Phosphate (CPP-ACP) on white spot lesions in post-orthodontic patients in a given period of time...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
A Kensche, S Pötschke, C Hannig, G Richter, W Hoth-Hannig, M Hannig
For the purpose of erosion prevention the present study aimed to compare the efficacy of two biomimetic products and a fluoride solution to optimize the protective properties of the pellicle. After 1 min of in situ pellicle formation on bovine enamel slabs, 8 subjects adopted CPP-ACP (GC Tooth Mousse), a mouthwash with hydroxyapatite microclusters (Biorepair), or a fluoride based mouthwash (elmex Kariesschutz) for 1 min each. Afterwards, samples were exposed in the oral cavity for 28 min. Native enamel slabs and slabs exposed to the oral cavity for 30 min without any rinse served as controls...
2016: TheScientificWorldJournal
Abbas Rizvi, Muhammad S Zafar, Yasser Al-Wasifi, Wamiq Fareed, Zohaib Khurshid
OBJECTIVE: This study is aimed to establish the microtensile bond strength of enamel following exposure to an aerated drink at various time intervals with/without application of remineralization agent. In addition, degree of remineralization and demineralization of tooth enamel has been assessed using polarized light microscopy. MATERIALS AND METHODS: Seventy extracted human incisors split into two halves were immersed in aerated beverage (cola drink) for 5 min and stored in saliva until the time of microtensile bond testing...
July 2016: European Journal of Dentistry
Selcuk Savas, Fevzi Kavrìk, Ebru Kucukyìlmaz
OBJECTIVE: The aim of this study was to evaluate the efficacy of CPP-ACP containing fluoride varnish for remineralizing white spot lesions (WSLs) with four different quantitative methods. MATERIAL AND METHODS: Four windows (3x3 mm) were created on the enamel surfaces of bovine incisor teeth. A control window was covered with nail varnish, and WSLs were created on the other windows (after demineralization, first week and fourth week) in acidified gel system. The test material (MI Varnish) was applied on the demineralized areas, and the treated enamel samples were stored in artificial saliva...
May 2016: Journal of Applied Oral Science: Revista FOB
Noorjahan Laila Huq, Helen Myroforidis, Keith J Cross, David P Stanton, Paul D Veith, Brent R Ward, Eric C Reynolds
The repair of early dental caries lesions has been demonstrated by the application of the remineralisation technology based on casein phosphopeptide-stabilised amorphous calcium phosphate complexes (CPP-ACP). These complexes consist of an amorphous calcium phosphate mineral phase stabilised and encapsulated by the self-assembly of milk-derived phosphopeptides. During topical application of CPP-ACP complexes in the oral cavity, the CPP encounters the enamel pellicle consisting of salivary proteins and peptides...
2016: International Journal of Molecular Sciences
M C Jordão, C R B Alencar, I M Mesquita, M A R Buzalaf, A C Magalhães, M A A M Machado, H M Honório, D Rios
The erosion-protective effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) is controversial. This study aimed to investigate the ability of CPP-ACP chewing gum to prevent a single event of erosive demineralization in situ. Bovine enamel blocks (n = 120) were randomly assigned to 3 phases according to the baseline surface hardness: phase I (PI) - chewing gum with CPP-ACP, phase II (PII) - chewing gum without CPP-ACP, and control phase (PIII) - salivary effect without stimulation (no gum). Nineteen volunteers participated in this study during 3 crossover phases of 2 h...
2016: Caries Research
Yu Wang, Li Mei, Lin Gong, Jialing Li, Shaowei He, Yan Ji, Weibin Sun
BACKGROUND: Demineralization can be arrested or reversed when remineralization agents are applied to incipient carious or non-cavitated carious lesions. A large number of therapeutic agents including non-fluoridated products have been developed to promote enamel remineralization. OBJECTIVE: This study aims to evaluate the efficacy of different bioactive elements containing toothpastes in remineralization of artificial enamel lesions. METHODS: Artificial carious lesions were created on 40 human enamel slabs, and were randomly divided into four groups: (1) control group (no treatment), (2) casein phosphopeptide-amorphous calcium phosphate group (CPP-ACP, GC Tooth Mousse), (3) 8% arginine and calcium carbonate group (ACC, Colgate Sensitive Pro-Relief), (4) calcium sodium phosphosilicate group (CSP, NovaMin®)...
September 14, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
Jyothi Kashi Nanjundasetty, Mohammed Ashrafulla
AIM: To assess and compare the incidence and intensity of experienced after an in-office vital tooth bleaching in case of dental fluorosis using two different types of desensitizing agents, at different time periods. MATERIALS AND METHODS: Sixty-nine subjects with mild-to-moderate fluorosis were randomly divided into three groups of 23 each. Group I - control group (placebo), group II-potassium nitrate 5% and sodium monofluorophosphate 0.7% (Sensodent KF), and group III-Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) (Tooth Mousse)...
May 2016: Journal of Conservative Dentistry: JCD
Thiago da Rosa Nogueira, Larissa Dias Alexandrino, Yasmin do Socorro Batista de Lima Gomes, Cristiane de Melo Alencar, Eliane Bemerguy Alves, Cecy Martins Silva
AIM: The aim of this study was to use surface rugosity analysis (Ra) and scanning electron microscopy (SEM) comparing effects of nano-hydroxyapatite (NANO), casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), and NovaMin (NOVA) on enamel's human morphology bleached with 37.5% hydrogen peroxide. MATERIALS AND METHODS: Forty specimens (3 × 3 × 3 mm) were obtained from fully included third molars and four specimens were attached in the first molars of the volunteers...
2016: Journal of Contemporary Dental Practice
V Gopalakrishnan, R P Anthonappa, N M King, A Itthagarun
AIM: To evaluate (1) the remineralizing potential of Tooth Mousse(®) (TM) on artificial carious lesions, when applied for 1 min, and (2) the benefit of a fluoridated dentifrice prior to TM application. METHODS: Demineralisation caries-like lesions 120-200 μm deep were produced by placing molars in demineralizing solution for 96 h, sections 100-150 μm thick were then randomly assigned to four groups. Specimens were treated thrice daily with a non-fluoridated (Group A), or fluoridated dentifrice (1000 ppm) (Group B), or TM (Group C), or a fluoridated dentifrice followed by TM (Group D) then subjected to a 10-day pH cycling model...
August 2016: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
Homayoom Alaghemand, Sedighe Sadat Hashemi Kamangar, Nafiseh Zarenegad, Negin Tabari, Hoorieh Abedi, Soraya Khafri
OBJECTIVES: Bleached enamel is more susceptible to staining, and application of remineralizing agents may decrease enamel susceptibility to staining. This study sought to assess the effect of casein phosphopeptide amorphous calcium phosphate (CPP-ACP) on enamel susceptibility to staining during bleaching treatment. MATERIALS AND METHODS: Forty central and lateral incisors and first premolar teeth were evaluated in four groups of 10. Group one specimens were subjected to in-office bleaching...
August 2015: Journal of Dentistry of Tehran University of Medical Sciences
Andressa Feitosa Bezerra de Oliveira, Luciana Vilar de Oliveira Diniz, Franklin Delano Soares Forte, Fabio Correia Sampaio, Renzo Alberto Ccahuana-Vásquez, Bennett Tochukwu Amaechi
OBJECTIVES: The purpose of this study is to analyze the in situ effect of a casein phosphopeptide-stabilized amorphous calcium phosphate (CPP-ACP) chewing gum on human enamel erosion lesion associated or not with abrasion. MATERIAL AND METHODS: A three-way crossover study of 7 days was conducted involving 10 volunteers subjected to the same protocol: (G1) CPP-ACP sugar-free chewing gum, (G2) regular sugar-free chewing gum without CPP-ACP, and (G3) saliva-no chewing gum...
March 28, 2016: Clinical Oral Investigations
Zoha Abdullah, Joseph John
PURPOSE: To evaluate the efficacy of minimally invasive methods for the treatment of white-spot lesions involving fluorides, CPP-ACP (casein phosphopeptide-stabilised amorphous calcium phosphate) and resin infiltration vs a placebo or control. MATERIALS AND METHODS: According to predetermined criteria, four databases were searched for eligible studies. References of the selected articles and relevant reviews were searched for any missed publications. RESULTS: Eight randomised controlled trials were selected as eligible studies, and only qualitative analyses were performed because of the diversity of the interventions and outcome measures...
2016: Oral Health & Preventive Dentistry
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