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https://www.readbyqxmd.com/read/29932947/long-term-risk-of-seizures-among-cardiac-arrest-survivors
#1
Nicholas A Morris, Teresa L May, Melissa Motta, Sachin Agarwal, Hooman Kamel
INTRODUCTION: The long-term risk of seizures in cardiac arrest survivors is not established. We hypothesized that survivors of cardiac arrest face an increased long-term risk for seizures. METHODS: We performed a retrospective cohort study using 2008-2015 claims data from a nationally representative 5% sample of Medicare beneficiaries ≥ 66 years-old. Our exposure of interest was a hospital diagnosis code of cardiac arrest, defined by previously validated ICD-9-CM codes...
June 19, 2018: Resuscitation
https://www.readbyqxmd.com/read/29931814/a-history-of-undescended-testes-in-young-men-with-klinefelter-syndrome-does-not-reduce-the-chances-for-successful-microsurgical-testicular-sperm-extraction
#2
M W Ragab, J-F Cremers, M Zitzmann, E Nieschlag, S Kliesch, J Rohayem
Klinefelter syndrome (KS) and undescended testes (UDT) are known etiologies for non-obstructive azoospermia (NOA), and coexistence of both etiologies is not uncommon. Patients with both KS and a history of UDT are therefore considered to have extremely reduced chances for paternity. We aimed to analyze the impact of previous surgically corrected unilateral or bilateral UDT on sperm retrieval rates (SRRs) by microsurgical testicular sperm extraction (mTESE) in azoospermic men with KS. Age, testicular volumes, and hypothalamo-pituitary-gonadal axis function were investigated in relation to SRRs in 29 non-mosaic KS patients (47,XXY) with a history of UDT (group 1) who underwent mTESE between 2008 and 2016 in our center and compared to the data of age- and serum testosterone-matched non-mosaic KS controls with eutopic testes at birth (group 2), and to those of 51 men with NOA and a normal male karyotype (46,XY), but previous UDT (group 3)...
June 21, 2018: Andrology
https://www.readbyqxmd.com/read/29931626/do-sarcopenia-and-or-osteoporosis-increase-the-risk-of-frailty-a-4-year-observation-of-the-second-and-third-road-study-surveys
#3
N Yoshimura, S Muraki, H Oka, T Iidaka, R Kodama, C Horii, H Kawaguchi, K Nakamura, T Akune, S Tanaka
In this 4-year follow-up study including 1083 subjects (≥ 60 years), the prevalence of frailty was estimated to be 5.6%; osteoporosis was found to be significantly associated with frailty. Moreover, the presence of both osteoporosis and sarcopenia increased the risk of frailty compared to the presence of osteoporosis or sarcopenia alone. INTRODUCTION: This study aims to examine the contribution of sarcopenia and osteoporosis to the occurrence of frailty using 4-year follow-up information of a population-based cohort study...
June 21, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29931426/validation-of-the-new-ajcc-eighth-edition-of-the-tnm-classification-for-breast-cancer-with-a-single-center-breast-cancer-cohort
#4
Ji-Yeon Kim, Ji Eun Lim, Hae Hyun Jung, Soo Youn Cho, Eun Yoon Cho, Se Kyung Lee, Jong Han Yu, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam, Yeon Hee Park, Jin Seok Ahn, Young-Hyuck Im
PURPOSE: The new eighth edition TNM classification by the AJCC for breast cancer (BC) incorporates biologic factors and gene expression prognostic panels, in addition to traditional anatomic factors. In this study, we evaluated the prognostic value of this new staging system compared to the previous AJCC 7th edition staging system. METHODS: We conducted a retrospective analysis of women with stage I, II, or III BC who underwent curative surgery with/without adjuvant systemic therapy at Samsung Medical Center between July 2004 and December 2008...
June 21, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29931161/frailty-is-associated-with-mortality-in-patients-aged-50-years-and-older
#5
Kathleen S Romanowski, Eleanor Curtis, Tina L Palmieri, David G Greenhalgh, Soman Sen
Recent evidence indicates that increased frailty is associated with increased mortality in patients with burn over the age of 65 years. However, the effect of frailty may not be restricted to those over the age of 65 years. We hypothesize that admission frailty is associated with mortality in patients with burn ≥50 years of age. We performed a 5-year (2008-2013) retrospective review of patients with acute burn aged 50 years or older. Data collected included demographics, injury characteristics, outcomes, and discharge disposition...
December 4, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29929484/contemporary-rates-and-predictors-of-fast-progression-of-chronic-kidney-disease-in-adults-with-and-without-diabetes-mellitus
#6
Alan S Go, Jingrong Yang, Thida C Tan, Claudia S Cabrera, Bergur V Stefansson, Peter J Greasley, Juan D Ordonez
BACKGROUND: Chronic kidney disease (CKD) is highly prevalent but identification of patients at high risk for fast CKD progression before reaching end-stage renal disease in the short-term has been challenging. Whether factors associated with fast progression vary by diabetes status is also not well understood. We examined a large community-based cohort of adults with CKD to identify predictors of fast progression during the first 2 years of follow-up in the presence or absence of diabetes mellitus...
June 22, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29929451/predictors-of-neck-reoperation-and-mortality-after-initial-total-thyroidectomy-for-differentiated-thyroid-cancer
#7
Thomas J Semrad, Theresa Keegan, Alison M Semrad, Ann Brunson, D Gregory Farwell
BACKGROUND: In an era of rising differentiated thyroid cancer incidence, the rate and impact of neck reoperation may inform the intensity of earlier interventions and surveillance. In this study, we sought to define predictors of neck reoperation and to assess its impact on survival. METHODS: Using California Cancer Registry linked to California Office of Statewide Health Planning and Development records, we performed a retrospective cohort study of 24,230 patients with total or near total thyroidectomy for papillary or follicular thyroid cancer during 1991-2008 and follow up through 2013...
June 21, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29928454/the-prognostic-value-of-the-systemic-inflammatory-score-in-patients-with-unresectable-metastatic-colorectal-cancer
#8
Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shinji Matsutani, Kenjiro Kimura, Ryosuke Amano, Kosei Hirakawa, Masaichi Ohira
Inflammation has been widely recognized as a contributor to cancer progression and several inflammatory markers have been reported as associated with the clinical outcomes in patients with various types of cancer. Recently, a novel inflammatory marker, the systemic inflammatory score (SIS), which is based on a combination of the lymphocyte-to-monocyte ratio (LMR) and the serum albumin concentration has been reported as a useful prognostic marker. The aim of the present study was to assess the prognostic value of the SIS in patients with unresectable metastatic colorectal cancer (mCRC)...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928379/safety-and-feasibility-of-single-port-laparoscopic-multivisceral-resection-for-locally-advanced-left-colon-cancer
#9
Mitsuyoshi Tei, Masahisa Otsuka, Yozo Suzuki, Kentaro Kishi, Masahiro Tanemura, Hiroki Akamatsu
The aim of the present study was to evaluate the safety and feasibility of single-port laparoscopic multivisceral resection (S-MVR) for locally advanced left colon cancer. S-MVR is a challenging technique and to the best of our knowledge this is the first report of S-MVR for left colon cancer invading or adhering to neighboring organs. A retrospective review was conducted of patients who underwent laparoscopic multivisceral resection for locally advanced left colon cancer invading or adhering to neighboring organs from January 2008 to December 2014...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928230/can-electronic-health-records-databases-complement-spontaneous-reporting-system-databases-a-historical-reconstruction-of-the-association-of-rofecoxib-and-acute-myocardial-infarction
#10
Vaishali K Patadia, Martijn J Schuemie, Preciosa M Coloma, Ron Herings, Johan van der Lei, Miriam Sturkenboom, Gianluca Trifirò
Background: Several initiatives have assessed if mining electronic health records (EHRs) may accelerate the process of drug safety signal detection. In Europe, Exploring and Understanding Adverse Drug Reactions (EU-ADR) Project Focused on utilizing clinical data from EHRs of over 30 million patients from several European countries. Rofecoxib is a prescription COX-2 selective Non-Steroidal Anti-Inflammatory Drugs (NSAID) approved in 1999. In September 2004, the manufacturer withdrew rofecoxib from the market because of safety concerns...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29927863/endoscopic-esophageal-vacuum-therapy-a-novel-therapy-for-esophageal-perforations-in-pediatric-patients
#11
Michael A Manfredi, Susannah J Clark, Steven J Staffa, Peter D Ngo, C Jason Smithers, Thomas E Hamilton, Russell W Jennings
BACKGROUND: Esophageal perforation is a potentially life-threatening problem if not quickly diagnosed and treated appropriately. Negative pressure wound therapy (NPWT), commercially known as V.A.C.® therapy, was developed in the early 1990 s and is now standard of care for chronic surface wounds, ulcers, and burns. Adapting vacuum sponge therapy for use intraluminally for perforations of the esophagus was first reported in 2008. We report the first pediatric experience on a customized esophageal vacuum assisted closure (EVAC) device for closure of esophageal perforations...
June 20, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29927625/roadside-survey-of-alcohol-and-drug-use-among-norwegian-drivers-in-2016-17-a-follow-up-of-the-2008-9-survey
#12
Håvard Furuhaugen, Ragnhild E G Jamt, Galina Nilsson, Vigdis Vindenes, Hallvard Gjerde
OBJECTIVE: To study the use of alcohol and drugs among the general driving population in the south-eastern part of Norway and to compare the findings with the results from a similar roadside survey in 2008-9. METHODS: A roadside survey of drivers of cars, vans, motorcycles and mopeds was performed from April 2016 to April 2017 in collaboration with the Mobile Police Service. Oral fluid was collected using the Quantisal device and analysed for alcohol, illicit drugs and psychoactive medicinal drugs...
June 21, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29926962/self-efficacy-did-not-predict-the-outcome-of-the-transition-to-adult-care-in-adolescents-with-inflammatory-bowel-disease
#13
Gertrude van den Brink, Martha A C van Gaalen, Marieke Zijlstra, Lissy de Ridder, C Janneke van der Woude, Johanna C Escher
AIM: It can be difficult for adolescents with inflammatory bowel disease (IBD) to make the transition from paediatric to adult care. We studied the outcomes of this process and defined what constituted a successful transition. METHODS: In 2008, 50 adolescents who attended our IBD transition clinic completed IBD-yourself, a self-efficacy questionnaire that we had previously developed and validated. We approached the subjects in 2014, two to six years after they transferred to adult care, and 35 agreed to take part in the current study...
June 21, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29926904/mesh-use-in-urogynaecological-procedures-between-2005-and-2016-an-australian-cohort-study
#14
Marianne H Gillam, Mhairi Kerr, Nicole L Pratt, Renly Lim, Elizabeth E Roughead
BACKGROUND: Pelvic organ prolapse (POP) and stress urinary incontinence (SUI) are common conditions. The use of mesh in the surgical treatment of these conditions in Australia is unclear. AIM: To examine the use of mesh in POP and SUI procedures in an Australian national cohort of older women. METHODS: We conducted a population-based cohort study using data from the Australian Government Department of Veterans' Affairs (DVA) database. The cohort consisted of older women who had POP and SUI procedures between 1 July, 2005 and 31 December, 2016...
June 21, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29926891/hydroa-vacciniforme-like-lymphoproliferative-disorder-in-an-elderly-chinese-patient-and-a-literature-review-of-adult-cases
#15
REVIEW
Valencia Long, Michelle W Liang, Suat Hoon Tan
Hydroa vaccinforme-like lymphoproliferative disorder (HVLPD) is a rare T-cell lymphoproliferative disorder driven by the Epstein-Barr Virus (EBV). It was initially designated under the 2008 WHO classification of tumors of hematopoietic and lymphoid tissues as a distinct entity but has been recently reclassified as a lymphoproliferative disorder under the 2016 revision of the 2008 WHO classification of lymphoid malignancies. HVLPD mainly affects Asian, Central, and South American children. It is rarely seen in adults...
June 21, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29926439/characteristics-of-sauna-deaths-in-korea-in-relation-to-different-blood-alcohol-concentrations
#16
Kyung-Moo Yang, Bong-Woo Lee, Jaeseong Oh, Seong Ho Yoo
Although the benefits of sauna bathing have been demonstrated in epidemiological studies, sauna deaths have been reported. The aim of this study was to determine the demographic and forensic characteristics associated with different blood alcohol concentrations (BACs) in sauna deaths in Korea. In this retrospective analysis, data were collected from a nationwide pool in Korea between January 2008 and December 2015 to determine the role of alcohol intoxication in sauna deaths based on the subjects' BAC and to evaluate the demographic and forensic characteristics associated with different BACs...
June 21, 2018: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29925433/target-achievement-and-cardiovascular-event-rates-with-lomitapide-in-homozygous-familial-hypercholesterolaemia
#17
Dirk J Blom, Marina Cuchel, Miranda Ager, Helen Phillips
BACKGROUND: Homozygous familial hypercholesterolaemia (HoFH) is characterized by a markedly increased risk of premature cardiovascular (CV) events and cardiac death. Lomitapide reduces low-density lipoprotein cholesterol (LDL-C) levels; however, the probable impact on LDL-C goals and CV events is unknown. METHODS: We used data collected in the first 26 weeks of the lomitapide pivotal phase 3 study (NCT00730236) to evaluate achievement of European Atherosclerosis Society (EAS) LDL-C targets...
June 20, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29925390/characteristics-and-survival-outcomes-related-to-the-infra-pyloric-lymph-node-status-of-gastric-cancer-patients
#18
Wei-Han Zhang, Xiao-Hai Song, Xin-Zu Chen, Kun Yang, Kai Liu, Zhi-Xin Chen, Zong-Guang Zhou, Jian-Kun Hu
BACKGROUND: To study metastasis to the infra-pyloric (no. 6) lymph nodes and their subgroups and the related risk factors of gastric cancer patients. METHODS: Gastric cancer patients who underwent gastrectomy with complete postoperative pathological information on the no. 6 lymph node station and its subgroups from January 1, 2008, to December 31, 2011, were included. The clinicopathological characteristics and survival outcomes were analyzed. RESULTS: A total of 121 patients were included; they had 6...
June 20, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29925360/hand-foot-mouth-disease-and-use-of-steroids-intravenous-immunoglobulin-and-traditional-chinese-herbs-in-a-tertiary-hospital-in-shantou-china
#19
Dangui Zhang, Jieling Chen, William Ba-Thein
BACKGROUND: In contrast to the guidelines of World Health Organization (WHO) and United States-Centers for Disease Control and prevention (US-CDC), the Chinese national guidelines recommend the use of steroids, intravenous immunoglobulin (IVIG), or traditional Chinese herbs (TCHs) in hand-foot-mouth disease (HFMD) management. Their use and therapeutic efficacies are, however, unclear. We aimed to describe their use in and the clinical outcomes of hospitalized HFMD cases. METHODS: A retrospective review of hospital medical records for HFMD cases during 2008-2016 was conducted in a medical school-affiliated tertiary hospital in Shantou, Guangdong, China...
June 20, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29924770/potential-drug-drug-interactions-with-antimicrobials-in-hospitalized-patients-a-multicenter-point-prevalence-study
#20
Ferit Kuscu, Aslihan Ulu, Ayse S Inal, Bedia M Suntur, Hande Aydemir, Serdar Gul, Kenan Ecemis, Suheyla Komur, Behice Kurtaran, Ozlem Ozkan Kuscu, Yesim Tasova
BACKGROUND Improper use of antimicrobials can cause adverse drug events and high costs. The purpose of this study was to investigate the frequency and potential drug-drug interactions associated with antimicrobials among hospitalized patients. MATERIAL AND METHODS This study was conducted on the same day in 5 different hospitals in Turkey. We included patients aged ³18 years who received at least 1 antimicrobial drug and at least 1 of any other drug. The Micromedex® online drug reference system was used to control and describe the interactions...
June 20, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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