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N At van der Maas, R Donken, M J M Te Wierik, C M Swaan, S J M Hahne, H E de Melker
INTRODUCTION: Despite sustained high vaccination coverage and a national guideline by the Health Council (HC-guideline) on tetanus postexposure prophylaxis (T-PEP), tetanus sporadically occurs in the Netherlands. This study aims to assess the added value of a bedside test for tetanus immunity (Tetanos Quick Stick (TQS); Ingen BioSciences Group, France), in the context of routine T-PEP in two adult cohorts: those born before introduction of tetanus toxoid vaccination in the National Immunization Programme (NIP) in 1957 (pre-NIP-cohort; n=196) and those born after (NIP-cohort; n=405)...
November 2016: Emergency Medicine Journal: EMJ
D Nicolaï, A Farcet, C Molines, G Delalande, F Retornaz
INTRODUCTION: Tetanus is a serious disease, which could be potentially lethal. All cases are observed in patients inadequately immunized. The immunochromatographic tests (including Tetanos quick Stick(®) [TQS]) have demonstrated their efficiency in emergency setting. The aim of our study was to assess the usefulness of these tests in elderly outpatients seen in ambulatory settings. MATERIALS: This prospective study included patients aged 65 years and over who presented to the outpatients' clinic of the Gerontologic Departmental Center (Marseille)...
May 2015: La Revue de Médecine Interne
Dieynaba S N'Diaye, Michaël Schwarzinger, Dorothée Obach, Julien Poissy, Sophie Matheron, Enrique Casalino, Yazdan Yazdanpanah
BACKGROUND: Tétanos Quick Stick® (TQS) is a test for tetanus immunity screening for wounded patients in emergency departments (EDs), but represents additional costs compared with a medical interview on vaccination history. The study objective was to assess the effectiveness and cost of the TQS in French EDs. METHODS: We performed a model-based analysis that simulates screening of tetanus immunity and risk of tetanus based on prophylaxis administration. Strategies compared were: i) diagnosis of tetanus immunity by "TQS"; ii) "Medical Interview" (current practice)...
November 19, 2014: BMC Infectious Diseases
Adebola E Orimadegun, Akinlolu A Adepoju, Olusegun O Akinyinka
BACKGROUND: The low uptake of tetanus vaccine and its resultant high burden of tetanus in Nigeria suggest the need to improve routine and booster vaccination in children and adolescents. However, epidemiological evidence for vaccination in the adolescent age group needed for effective strategy and policy formulation is lacking. This study was carried out to determine the prevalence of protective immunity against tetanus and to identify risk factors for non-protective immunity among schooling adolescents...
March 17, 2014: Italian Journal of Pediatrics
Adebola Emmanuel Orimadegun, Bose Etaniamhe Orimadegun, Akinlolu Adedayo Adepoju
Seroepidemiological studies of tetanus in Africans have focused mainly on adults especially pregnant women and data on children are scarcely reported. We investigated the seroprevalence of protective immunity level, determined risk factors for non-protection against tetanus, and evaluated the performance of Tetanos Quick Stick(®) (TQS) among hospitalized children aged 1-9 years in Nigeria. Blood IgG antibody levels to tetanus was determined using enzyme-linked immunosorbent assay (ELISA) in the laboratory and TQS (an immunochromatographic test) at the bedside for 304 children admitted into emergency unit of a tertiary hospital in Ibadan, Nigeria...
2013: Frontiers in Neurology
Isabelle-Marie Descamps-Pouchelle, François Mortreux, Anne-Sophie Sergent-Roumier, Bernard Gressier
In front of the increase of frequentation of emergency departments for pathological situations associated with tetanic risk, and the difficulty to know if the patients are immunized or not, the consequence is an unsuitable consumption of vaccination and/or antitetanic immunoglobulins. At the emergency department of Armentieres's hospital, in a perspective of an accreditation and following a medical request, we wanted to improve patient's care with tetanic risk wound by using a quick test for the detection of specific antitetanic antibodies (tetanos Fumouze test), under laboratory's authority...
July 2010: Annales de Biologie Clinique
D Elkharrat, M-J Sanson-Le-Pors, L Arrouy, A Beauchet, F Benhamou
BACKGROUND: Unscheduled tetanus prophylaxis (UTP) used in the emergency room (ER) in patients with wounds who are unaware of their vaccination history is erroneous in 40% of cases. Evaluation of bedside tetanus immunity with the Tétanos Quick Stick (TQS) test may improve UTP. OBJECTIVES: To show that (1) a positive TQS result reflects immunity to tetanus; and (2) TQS is reproducible by ER workers. METHODS: In a prospective concordance study, immunity to tetanus of patients with wounds was assessed by two techniques: (1) TQS at the bedside, which detects specific tetanus antitoxins at concentrations > or =0...
January 2010: Emergency Medicine Journal: EMJ
Maria Paulke-Korinek, Pamela Rendi-Wagner, Michael Kundi, Batya Tomann, Ursula Wiedermann, Herwig Kollaritsch
BACKGROUND: When deciding whether to administer a tetanus vaccination--for international travel or injury--a subject's vaccination certificate should be investigated. As many people lack valid vaccination cards and are unable to recall their vaccination history, the Tetanos Quick Stick (TQS) test rapidly detects protective tetanus immunoglobulin IgG antibodies in whole blood, serum, or plasma. This immunochromatographic dipstick test yields a positive or negative result. METHODS: Our study evaluates the effectiveness of the TQS test by comparing the binary TQS test results of 100 sera with the tetanus antibody levels as measured by the standardized enzyme-linked immunosorbent assay (ELISA) method...
November 2008: Journal of Travel Medicine
S Rioja, J Jund, J Gaillat
UNLABELLED: The prevalence of pertussis in newborns led French health authorities to recommend using a booster dose at 13 years of age, and adding a booster dose for parents, siblings, and health care workers. OBJECTIVE: The aim of the study was to check if the new recommendations were applied by health care workers and if mothers still in the maternity ward were informed and agreed with these recommendations. METHOD: A questionnaire assessing knowledge, acceptance of the recommendations was sent to different health care workers and given to mothers in two maternity wards...
July 2008: Médecine et Maladies Infectieuses
Muriel Stubbe, Luc J M Mortelmans, Didier Desruelles, Rohnny Swinnen, Marc Vranckx, Edmond Brasseur, Philippe E Lheureux
BACKGROUND: The choice of tetanus prophylaxis for patients with wounds depends on obtaining their vaccination history, which has been demonstrated to be unreliable. Use of a rapid immunoassay (Tétanos Quick Stick, the TQS), combined with knowledge of certain demographic characteristics, may improve the evaluation of tetanus immunity and thus help to avoid inadequate prophylactic measures and reduce costs. OBJECTIVES: To evaluate the contribution of the TQS in the choice of tetanus prophylaxis and to perform a cost-effectiveness analysis...
September 2007: Emergency Medicine Journal: EMJ
Muriel Stubbe, Rohnny Swinnen, Alain Crusiaux, Françoise Mascart, Philippe E Lheureux
BACKGROUND: In most emergency departments, tetanus prophylaxis currently relies on vaccination history. Bedside evaluation of tetanus immunity may improve this process. OBJECTIVES: (i) To determine the seroprevalence of tetanus immunity; (ii) to evaluate the accuracy of vaccination history in assessing tetanus immunity; (iii) to identify factors predictive of seroprotection and incorrect history. METHOD: In a prospective observational study, tetanus immunity was assessed in 784 adults using Tétanos Quick Stick (TQS)...
February 2007: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
Isabelle Colombet, Colette Saguez, Marie-José Sanson-Le Pors, Benoît Coudert, Gilles Chatellier, Pierre Espinoza
Diagnosis of tetanus immunization status by medical interview of patients with wounds is poor. Many protected patients receive unnecessary vaccine or immunoglobulin, and unprotected patients may receive nothing. The aim of this study is to evaluate the feasibility and accuracy of the Tetanos Quick Stick (TQS) rapid finger prick stick test in the emergency department for determining immunization status. We designed a prospective multicenter study for blinded comparison of TQS with an enzyme-linked immunosorbent assay (ELISA)...
September 2005: Clinical and Diagnostic Laboratory Immunology
M-P Perriol, D Devos, J-F Hurtevent, S Gautier, J Caron, A Destée
INTRODUCTION: Anti-tetanus vaccination is considered to be very safe. However complications such as mononevritis, multinevritis or even polyradiculonevritis can be encountered. OBSERVATION: An 85-year-old man was admitted to our unit after a traffic accident caused by stroke. Seventy-two hours later the patient developed tetraplegia within a few hours, caused by neuropathy secondary to anti-tetanus vaccination. DISCUSSION: In this elderly patient, the rapid onset and severe presentation of the tetraplegia as well as the past history of normal vaccination and the axonal form of the neuropathy could have led to a misdiagnosis of neuropathy after booster anti-tetanus vaccination...
October 2004: Revue Neurologique
No abstract text is available yet for this article.
June 1954: Acta Medica Italica di Malattie Infettive e Parassitarie
Martin Deschêenes, Bin Hu
Though most experimental evidence indicates that the corticothalamic (CT) pathway would exert a direct excitatory action on thalamic relay neurons, the electrophysiological features of this excitation have never been clearly described. A methodological problem in previous electrophysiological studies was that direct corticofugal effects on relay cells could not be separated from those mediated by collateral activation of reticular thalamic neurons. In the present study, the reticular complex was lesioned by kainic acid and the CT response of relay neurons of the ventral lateral nucleus was recorded intracellularly in cats under pentobarbital or urethane anaesthesia...
February 1990: European Journal of Neuroscience
F Cornille, B P Roques
The very high toxicity of tetanus neurotoxin (TeNT) and botulinum neurotoxin (BoNT) are related to their nature of zinc metallopeptidases able to selectively cleave small proteins involved in neurotransmitters exocytosis. At this time, there is no efficient and selective therapy towards tetanos and tobulism as well as protection against a possible spreading of the toxins. We have therefore investigated the minimum sequences of TeNT and BoNT substrates allowing an efficient and simple fluorescent dosage of the enzymatic activity to be developed...
1999: Journal de la Société de Biologie
L C Ferratto, A J Vaz, E D Camargo, A M de Souza
No abstract text is available yet for this article.
November 1990: Revista do Instituto de Medicina Tropical de São Paulo
M Vitris, J M Saissy, J Demaziere, M Seck, M Ndiaye, N Gaye, L Marcoux
A case of tétanos was treated through intrathecal injections of baclofen. This new technique was pioneered in Anglo-saxon countries and has made it possible in the present case to success fully treat a Mollaret's third-stage generalized tetanus, without a tracheotomy or controlled ventilation. Because of its simplicity low cost, this technique could be another way of treating African tetanus.
1991: Dakar Médical
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