Read by QxMD icon Read

10000 hours

Nils Kristian Skjaervold, Kathrine Knai, Nicolas Elvemo
It is well-known that blood glucose oscillates with a period of approximately 15 min (900 s) and exhibits an overall complex behaviour in intact organisms. This complexity is not thoroughly studied, and thus, we aimed to decipher the frequency bands entailed in blood glucose regulation. We explored high-resolution blood glucose time-series sampled using a novel continuous intravascular sensor in four pigs under general anaesthesia for almost 24 hours. In all time series, we found several interesting oscillatory components, especially in the 5000-10000 s, 500-1000 s, and 50-100 s regions (0...
2018: PloS One
Nan Deng, Zhangweiyi Liu, Xiaocheng Wang, Tiantian Fu, Weilin Xie, Yi Dong
We report a long-distance phase-stabilized millimeter-wave distribution over optical fibers, where the optical-link-induced phase noise is compensated with a high-precision photonic-generated millimeter-wave (mm-wave) voltage-controlled oscillator (VCO). The mm-wave VCO is realized based on pre-filtering and re-modulating optical spectral lines of an optical frequency comb (OFC). By adjusting the frequency spacing of the optical spectral lines extracted from the OFC, the phase error of the transmitted optical mm-wave signal can be compensated precisely...
January 8, 2018: Optics Express
Xiang-Yang Ye, Stephanie Y Chen, Shung Wu, David S Yoon, Haixia Wang, Zhenqiu Hong, Stephen P O'Connor, Jun Li, James J Li, Lawrence J Kennedy, Steven J Walker, Akbar Nayeem, Steven Sheriff, Daniel M Camac, Vidyhashankar Ramamurthy, Paul E Morin, Rachel Zebo, Joseph R Taylor, Nathan N Morgan, Randolph P Ponticiello, Thomas Harrity, Atsu Apedo, Rajasree Golla, Ramakrishna Seethala, Mengmeng Wang, Timothy W Harper, Bogdan G Sleczka, Bin He, Mark Kirby, David K Leahy, Jianqing Li, Ronald L Hanson, Zhiwei Guo, Yi-Xin Li, John D DiMarco, Raymond Scaringe, Brad Maxwell, Frederick Moulin, Joel C Barrish, David A Gordon, Jeffrey A Robl
BMS-816336 (6n-2), a hydroxy-substituted adamantyl acetamide, has been identified as a novel, potent inhibitor against human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme (IC50 3.0 nM) with >10000-fold selectivity over human 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). 6n-2 exhibits a robust acute pharmacodynamic effect in cynomolgus monkeys (ED50 0.12 mg/kg) and in DIO mice. It is orally bioavailable (%F ranges from 20 to 72% in preclinical species) and has a predicted pharmacokinetic profile of a high peak to trough ratio and short half-life in humans...
June 22, 2017: Journal of Medicinal Chemistry
Elena Chekmeneva, Gonçalo Dos Santos Correia, Queenie Chan, Anisha Wijeyesekera, Adrienne Tin, Jeffery Hunter Young, Paul Elliott, Jeremy K Nicholson, Elaine Holmes
Large-scale metabolic profiling requires the development of novel economical high-throughput analytical methods to facilitate characterization of systemic metabolic variation in population phenotypes. We report a fit-for-purpose direct infusion nanoelectrospray high-resolution mass spectrometry (DI-nESI-HRMS) method with time-of-flight detection for rapid targeted parallel analysis of over 40 urinary metabolites. The newly developed 2 min infusion method requires <10 μL of urine sample and generates high-resolution MS profiles in both positive and negative polarities, enabling further data mining and relative quantification of hundreds of metabolites...
April 7, 2017: Journal of Proteome Research
Vani Krishnamurthy, Srinivasa Murthy Doreswamy, Sushma Krishnagowda
INTRODUCTION: Peripheral Intravenous Catheters (PIV) are extensively used in sick neonates for administration of medicines and nutrition. When these PIVs are used on intermittent basis, they are flushed with saline in order to keep the hub of the catheter free from blood. Presence of blood in the hub of the catheter can be potentially dangerous as it could facilitate infection. AIM: The aim of this study was to find the magnitude of blood contamination of PIV catheter hub after routine flushing...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
C Ferreira, E Schnell, S Ahmad, T De La Fuente Herman
PURPOSE: To investigate the energy dependence of Gafchromic EBT3 film over a range of clinically used proton, photon and electron energies. METHODS: Proton beam energies of 117 and 204 MeV, corresponding respectively to ranges in water of 10 cm and 27 cm from a Mevion S250 double scatter system unit were used. Electron energies of 6 and 20 MeV and photon energies of 6 and 18 MV from a Varian Clinac 21EX Linac were used. Two pieces of film (5×5 cm(2) ) were irradiated sequentially for doses of 100, 500, and 1000 cGy for all energies and modalities...
June 2016: Medical Physics
Chao Tian, Lixin Wang, Kimberly A Novick
RATIONALE: High-precision analysis of atmospheric water vapor isotope compositions, especially δ(17) O values, can be used to improve our understanding of multiple hydrological and meteorological processes (e.g., differentiate equilibrium or kinetic fractionation). This study focused on assessing, for the first time, how the accuracy and precision of vapor δ(17) O laser spectroscopy measurements depend on vapor concentration, delta range, and averaging-time. METHODS: A Triple Water Vapor Isotope Analyzer (T-WVIA) was used to evaluate the accuracy and precision of δ(2) H, δ(18) O and δ(17) O measurements...
October 15, 2016: Rapid Communications in Mass Spectrometry: RCM
Haodong Wu, Weimin Cai, Mingce Long, Hairui Wang, Zhiping Wang, Chen Chen, Xiaofang Hu, Xiaojuan Yu
Here we demonstrate that sulfur dioxide (SO2) is efficiently captured via heterogeneous oxidation into sulfate on the surface of hydroxylated manganese dioxide (MnO2). Lab-scale activity tests in a fluidized bed reactor showed that the removal efficiency for a simulated flue gas containing 5000 mg·Nm(-3) SO2 could reach nearly 100% with a GHSV (gas hourly space velocity) of 10000 h(-1). The mechanism was investigated using a combination of experimental characterizations and theoretical calculations. It was found that formation of surface bound sulfate proceeds via association of SO2 with terminal hydroxyls...
June 7, 2016: Environmental Science & Technology
Jing Yang, Enwei Zhang, Xiaofeng Li, Yunhua Yu, Jin Qu, Zhong-Zhen Yu
Three dimensional reduced graphene oxide (RGO)/Ni foam composites are prepared by a facile approach without using harmful reducing agents. Graphene oxide is reduced by Ni foam directly in its aqueous suspension at pH 2 at room temperature, and the resultant RGO sheets simultaneously assemble around the pillars of the Ni foam. The RGO/Ni foam composite is used as a binder-free supercapacitor electrode and exhibits high electrochemical properties. Its areal capacitance is easily tuned by varying the reduction time for different RGO loadings...
January 27, 2016: ACS Applied Materials & Interfaces
Luz-María Torres, Liliana Rivera-Espinosa, Juan L Chávez-Pacheco, Carlos F Navas, Joel A Demetrio, Radamés Alemón-Medina, Francisca Trujillo, Martín Pérez, Martha M Zapata, Rocío Cárdenas, Citlaltepetl Salinas, Arnoldo Aquino, Rafael Velázquez-Cruz, Manuel-de-Jesús Castillejos
Ifosfamide blood concentrations are necessary to monitor its therapeutic response, avoiding any adverse effect. We developed and validated an analytical method by UPLC-MS/MS to quantify ifosfamide in dried blood spots (DBS). Blood samples were collected on Whatman 903® filter paper cards. Five 3 mm disks were punched out from each dried blood spot. Acetonitrile and ethyl acetate were used for drug extraction. Chromatographic separation was carried out in an Acquity UPLC equipment with a BEH-C18 column, 2.1 x 100 mm, 1...
2015: PloS One
Farzad Hadaegh, Mitra Hasheminia, Hengameh Abdi, Davood Khalili, Mohammadreza Bozorgmanesh, Banafsheh Arshi, Fereidoun Azizi
OBJECTIVE: Prehypertension is associated with cardiovascular disease (CVD). There is no study to examine the incidence and risk factors of prehypertension in a sex stratified setting. The aim of this study was to examine the effect modification of sex for different risk factors which predicts the progression from normotension to prehypertension in a Middle East population-based cohort, during a median follow-up of 9.2 years. METHODS: A multivariate Cox analysis was performed among 1466 and 2131 Iranian men and women, respectively, who were free of prehypertension, hypertension, CVD and diabetes at baseline and free of incident hypertension without preceding prehypertension at follow-up...
2015: PloS One
Seyed Adel Moallem, Amir Hooshang Mohamadpour, Khalil Abnous, Mojtaba Sankian, Hamid Reza Sadeghnia, Aristidis Tsatsakis, Shabnam Shahsavand
Erythropoietin (EPO) plays a critical role in the development of the nervous system. In this study, the effects of EPO in carbon monoxide (CO) neurotoxicity were examined. Rats were exposed to 3000 ppm CO for 1 h and then different doses of EPO were administrated intraperitoneally. After 24 h, glial fibrillary acidic protein (GFAP) levels in the serum were determined and water content of brain and the extravasation of a tracer (Evans blue) were measured. Brain lipid peroxidation, myeloperoxidase activity Myelin basic protein (MBP) and BAX/BcL2 protein relative expressions were determined...
December 2015: Food and Chemical Toxicology
Yuan Zhuang, Mengshi Zhang, Bin Chen, Ruixue Duan, Xuehong Min, Zhenyu Zhang, Fuxin Zheng, Huageng Liang, Zujin Zhao, Xiaoding Lou, Fan Xia
Telomerase is a widely used tumor biomarker for early cancer diagnosis. On the basis of the combined use of aggregation-induced emission (AIE) fluorogens and quencher, a quencher group induced high specificity strategy for detection of telomerase activity from cell extracts and cancer patients' urine specimens was creatively developed. In the absence of telomerase, fluorescence background is extremely low due to the short distance between quencher and AIE dye. In the addition of telomerase, fluorescence enhances significantly...
September 15, 2015: Analytical Chemistry
Beata Peplonska, Agnieszka Bukowska, Wojciech Sobala
BACKGROUND: Mounting epidemiological evidence suggests that night shift work may contribute to the etiology of increased body weight. The present study aimed to examine association between rotating night shift work and body mass index (BMI), and abdominal adiposity respectively among nurses and midwives. METHODS: A cross-sectional study was conducted among 724 female nurses and midwives, aged 40-60 years (354 rotating night shift and 370 daytime workers) in Łódź, Poland, between 2008 and 2011...
2015: PloS One
Mehrdad Mahdian, Mojtaba Sehat, Mohammad Reza Fazel, Alireza Moraveji, Mahdi Mohammadzadeh
BACKGROUND: Urban traffic accidents are an extensively significant problem in small and busy towns in Iran. This study tried to explore the epidemiological pattern of urban traffic accidents in Kashan and Aran-Bidgol cities, Iran. OBJECTIVES: This study aimed to assess various epidemiological factors affecting victims of trauma admitted to a main trauma center in Iran. PATIENTS AND METHODS: During a retrospective study, data including age, sex, injury type and pattern, outcome, hospital stay and treatment expenditures regarding urban Road Traffic Accidents (RTAs) for one year (March 2012-March 2013) were obtained from the registry of trauma research center, emergency medical services and deputy of health of Kashan University of Medical Sciences...
June 2015: Archives of Trauma Research
A Reshef, A Zanichelli, H Longhurst, A Relan, C E Hack
BACKGROUND: Recommended management of attacks of hereditary angioedema (HAE) due to C1 esterase inhibitor (C1-INH) deficiency (C1-INH-HAE) includes therapy with exogenous C1INH. Thrombotic/thromboembolic events (TEE) have been reported with plasma-derived C1INH, but so far none with recombinant human C1INH (rhC1INH). This phase III, randomized, placebo (saline)-controlled study evaluated the safety of rhC1INH 50 IU/kg for the treatment of acute attacks in 74 patients with C1-INH-HAE...
May 2015: Allergy
M Delahaye, K Lawrence, S J Ward, M Hoare
An ultra scale-down method is described to determine the response of cells to recovery by dead-end (batch) centrifugation under commercially defined manufacturing conditions. The key variables studied are the cell suspension hold time prior to centrifugation, the relative centrifugal force (RCF), time of centrifugation, cell pellet resuspension velocities, and number of resuspension passes. The cell critical quality attributes studied are the cell membrane integrity and the presence of selected surface markers...
May 2015: Biotechnology and Bioengineering
Dana M Qeblawi, Marc Campillo-Funollet, Carlos A Muñoz
STATEMENT OF PROBLEM: Although the use of anatomic-contour zirconia restorations has expanded in the recent past, disagreement still exists as to reliable cementation techniques and materials. PURPOSE: The purpose of this in vitro study was to compare the immediate and artificially aged shear bond strength of 2 commercially available self-adhesive resin cements to zirconia: one with silica coating and silanation as a zirconia surface treatment and the other contained a phosphate monomer, which eliminated the need for a separate primer...
February 2015: Journal of Prosthetic Dentistry
Atsushi Nishigori, Takamitsu Yoshida, Marco C Bottino, Jeffrey A Platt
STATEMENT OF PROBLEM: The influence of yttria-stabilized tetragonal zirconia polycrystal surface treatment on veneering porcelain shear bond strength after cyclic loading is not fully understood. PURPOSE: The purpose of this study was to investigate the influence of yttria-stabilized tetragonal zirconia polycrystal surface treatment on veneering porcelain shear bond strength and cyclic loading on the shear bond strength between the 2 materials. MATERIAL AND METHODS: A total of 48 cylinder-shaped yttria-stabilized tetragonal zirconia polycrystal specimens were fabricated with computer-aided design and computer-aided manufacturing (CAD/CAM), sintered for 8 hours at 1500°C, ground with 320-grit diamond paper, and divided into 4 groups (n = 12) according to surface treatment as follows: no treatment/control; heat treatment of 650°C to 1000°C at 55°C/min; airborne-particle abrasion with 50-μm alumina at 0...
December 2014: Journal of Prosthetic Dentistry
Charles R Clark, Ceinwen A Schreiner, Craig M Parker, Thomas M Gray, Gary M Hoffman
Sprague Dawley rats were exposed via inhalation to vapor condensates of either gasoline or gasoline combined with various fuel oxygenates to assess whether their use in gasoline influences the hazard of evaporative emissions. Test substances included vapor condensates prepared from an EPA described "baseline gasoline" (BGVC), or gasoline combined with methyl tertiary butyl ether (G/MTBE), ethyl t-butyl ether (G/ETBE), t-amyl methyl ether (G/TAME), diisopropyl ether (G/DIPE), ethanol (G/EtOH), or t-butyl alcohol (G/TBA)...
November 2014: Regulatory Toxicology and Pharmacology: RTP
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"