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https://www.readbyqxmd.com/read/29789814/endolymphatic-ethiodized-oil-intranodal-lymphangiography-and-cyanoacrylate-glue-embolization-for-the-treatment-of-postoperative-lymphatic-leak-after-robot-assisted-laparoscopic-pelvic-resection
#1
Hannah Hill, Ravi N Srinivasa, Joseph J Gemmete, Anthony Hage, Jacob Bundy, Jeffrey Forris Beecham Chick
Purpose: To report the approach, technical success, clinical outcomes, complications, and follow-up of ethiodized oil intranodal lymphangiography with cyanoacrylate glue embolization for the treatment of lymphatic leak after robot-assisted laparoscopic pelvic resection. Materials and Methods: Four men with mean age 68.7 ± 14.3 years were treated with ethiodized oil intranodal lymphangiography with cyanoacrylate embolization for postoperative lymphatic leak. Patients underwent either (1) cystoprostatectomy with ileal conduit and bilateral extensive pelvic lymph node dissection for muscle-invasive urothelial carcinoma and presented with postoperative lymphatic ascites ( n  = 2) or (2) prostatectomy with bilateral standard pelvic lymph node dissection for prostate carcinoma and presented with postoperative pelvic lymphoceles ( n  = 2)...
2018: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29783028/thoracic-duct-embolization-a-survey-of-practice-patterns
#2
Samantha A Jayasinghe, Ravi N Srinivasa, Anthony N Hage, Joseph J Gemmete, Bill S Majdalany, Jeffrey Forris Beecham Chick
PURPOSE: To determine training, treatment techniques, outcomes, and practice patterns of practitioners performing thoracic duct embolization (TDE). MATERIALS AND METHODS: From September to October of 2017, a 34-question survey focusing on training, treatment techniques, outcomes, and practice patterns of TDE was distributed through the Open Forum using the Society of Interventional Radiology Connect website. 54 practitioners completed the entire survey. Percentages were calculated for answers to the questions...
May 18, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29777221/chemokines-and-integrins-independently-tune-actin-flow-and-substrate-friction-during-intranodal-migration-of-t-cells
#3
Miroslav Hons, Aglaja Kopf, Robert Hauschild, Alexander Leithner, Florian Gaertner, Jun Abe, Jörg Renkawitz, Jens V Stein, Michael Sixt
Although much is known about the physiological framework of T cell motility, and numerous rate-limiting molecules have been identified through loss-of-function approaches, an integrated functional concept of T cell motility is lacking. Here, we used in vivo precision morphometry together with analysis of cytoskeletal dynamics in vitro to deconstruct the basic mechanisms of T cell migration within lymphatic organs. We show that the contributions of the integrin LFA-1 and the chemokine receptor CCR7 are complementary rather than positioned in a linear pathway, as they are during leukocyte extravasation from the blood vasculature...
May 18, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29765561/a-pilot-study-of-peptide-vaccines-for-vegf-receptor-1-and-2-in-patients-with-recurrent-progressive-high-grade-glioma
#4
Shunsuke Shibao, Ryo Ueda, Katsuya Saito, Ryogo Kikuchi, Hideaki Nagashima, Atsuhiro Kojima, Hiroshi Kagami, Eriel Sandika Pareira, Hikaru Sasaki, Shinobu Noji, Yutaka Kawakami, Kazunari Yoshida, Masahiro Toda
Object: Early-phase clinical studies of glioma vaccines have shown feasibility and encouraging preliminary clinical activity. A vaccine that targets tumor angiogenesis factors in glioma microenvironment has not been reported. Therefore, we performed a pilot study to evaluate the safety and immunogenicity of a novel vaccination targeting tumor angiogenesis with synthetic peptides for vascular endothelial growth factor (VEGF) receptor epitopes in patients with recurrent/progressive high grade gliomas...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29757895/a-novel-technique-in-the-treatment-of-lymphoceles-after-renal-transplantation-c-arm-cone-beam-ct-guided-percutaneous-embolization-of-lymphatic-leakage-following-lymphangiography
#5
İsmail Okan Yildirim, Turgut Pişkin, Enes Duman, Ali Firat, Murat Dogan, Hülya Taskapan, Idris Sahin, Kaya Sarac
BACKGROUND: We aimed to evaluate the efficacy of percutaneous embolization following lymphangiography using C-arm cone-beam computed tomography (CBCT) performed at the site of lymphatic leakage in patients with postrenal transplant lymphocele. METHODS: Between July 2014 and August 2017, 13 patients not responding to percutaneous ethanol sclerotherapy and conservative treatment for recurrent lymphocele following renal transplant were included. The mean age of the patients was 56...
May 11, 2018: Transplantation
https://www.readbyqxmd.com/read/29728746/-contrast-enhanced-ultrasound-in-the-diagnostic-workup-of-lymph-nodes
#6
REVIEW
H-P Weskott
CLINICAL/METHODICAL ISSUE: Daily tasks in sonographic diagnostics include detection and characterization of peripheral and abdominal lymph nodes. STANDARD RADIOLOGICAL METHODS: In addition to the B‑mode methods, color-coded Doppler sonography (CCDS) plays an important role in the evaluation of lymph nodes. METHODICAL INNOVATIONS: Contrast-enhanced ultrasound (CEUS) has become a standard procedure in vascular and organ diagnostics. Tissue perfusion can be recorded visually and retrospectively in real time using time-dependent intensity analysis...
May 4, 2018: Der Radiologe
https://www.readbyqxmd.com/read/29686670/alum-toll-like-receptor-7-adjuvant-enhances-the-expansion-of-memory-b-cell-compartment-within-the-draining-lymph-node
#7
Hoa Thi My Vo, Barbara Christiane Baudner, Stefano Sammicheli, Matteo Iannacone, Ugo D'Oro, Diego Piccioli
Vaccination is one of the most cost-effective health interventions and, with the exception of water sanitization, no other action has had such a major effect in mortality reduction. Combined with other approaches, such as clean water, better hygiene, and health education, vaccination contributed to prevent millions of cases of deaths among children under 5 years of age. New or improved vaccines are needed to fight some vaccine-preventable diseases that are still a threat for the public health globally, as reported also in the Global Vaccine Action Plan (GVAP) endorsed by the World Health Assembly in 2012...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29643231/personalized-cancer-vaccine-effectively-mobilizes-antitumor-t-cell-immunity-in-ovarian-cancer
#8
Janos L Tanyi, Sara Bobisse, Eran Ophir, Sandra Tuyaerts, Annalisa Roberti, Raphael Genolet, Petra Baumgartner, Brian J Stevenson, Christian Iseli, Denarda Dangaj, Brian Czerniecki, Aikaterini Semilietof, Julien Racle, Alexandra Michel, Ioannis Xenarios, Cheryl Chiang, Dimitri S Monos, Drew A Torigian, Harvey L Nisenbaum, Olivier Michielin, Carl H June, Bruce L Levine, Daniel J Powell, David Gfeller, Rosemarie Mick, Urania Dafni, Vincent Zoete, Alexandre Harari, George Coukos, Lana E Kandalaft
We conducted a pilot clinical trial testing a personalized vaccine generated by autologous dendritic cells (DCs) pulsed with oxidized autologous whole-tumor cell lysate (OCDC), which was injected intranodally in platinum-treated, immunotherapy-naïve, recurrent ovarian cancer patients. OCDC was administered alone (cohort 1, n = 5), in combination with bevacizumab (cohort 2, n = 10), or bevacizumab plus low-dose intravenous cyclophosphamide (cohort 3, n = 10) until disease progression or vaccine exhaustion. A total of 392 vaccine doses were administered without serious adverse events...
April 11, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29572939/computed-tomographic-appearance-of-abdominal-lymph-nodes-in-healthy-cats
#9
Michael Perlini, Andrew Bugbee, Scott Secrest
BACKGROUND: Computed tomography (CT) is commonly used in veterinary medicine and plays an important role in disease identification and cancer staging. Identification of abnormal abdominal lymph nodes is important for clinical, therapeutic, and prognostic decision making. No published study describes the CT appearance of abdominal lymph nodes in healthy cats. HYPOTHESIS/OBJECTIVES: All abdominal lymph centers will be identified on CT with the majority of lymph nodes being elongated and homogenously contrast enhancing...
March 23, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29551619/transinguinal-interstitial-intranodal-lymphatic-embolization-to-treat-high-output-postoperative-lymphocele
#10
Rajiv N Srinivasa, Jeffrey Forris Beecham Chick, Nishant Patel, Joseph J Gemmete, Ravi N Srinivasa
Postoperative lymphoceles may occur after abdominal or pelvic surgery secondary to disruption of lymphatic channels. First-line therapy includes conservative therapy with medical management and dietary restriction. Despite these measures, some patients may have persistent high-output lymphoceles requiring percutaneous aspiration, drainage, or sclerosis. Rarely, surgical evacuation is required. Management of intrathoracic chyle leak by thoracic duct embolization has been well described. Recently, interstitial (intranodal) lymphatic embolization for the treatment of plastic bronchitis has been performed...
May 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29546344/local-immunotherapy-of-cancer-innovative-approaches-to-harnessing-tumor-specific-immune-responses
#11
Vivek Murthy, Janna Minehart, Daniel H Sterman
Modern cancer immunotherapies represent a major shift in paradigm with respect to how we understand innate and adaptive responses to malignancy. Successful tumors co-opt normal immunosurveillance mechanisms by potent interactions between the tumor and local draining lymph nodes. Tumor cells mediate a complex and dynamic immunoediting procedure that results in increased vascular efflux into the draining lymphatics, an immunosuppressive microenvironment rich in regulatory T-lymphocytes, dysfunctional antigen presentation, and downregulation of normal effector lymphocyte responses...
December 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29524461/endolymphatic-interventions-for-the-treatment-of-chylothorax-and-chylous-ascites-in-neonates-technical-and-clinical-success-and-complications
#12
Rajiv N Srinivasa, Jeffrey Forris Beecham Chick, Joseph J Gemmete, Anthony N Hage, Ravi N Srinivasa
BACKGROUND: The aim of this study was to report the technical and clinical success of performing minimally invasive endolymphatic embolization in neonates presenting with a chylothorax or chylous ascites. METHODS: Three neonates, 2 males and 1 female, with a mean age of 28 days (range: 19-39 days) presented with a chylothorax or chylous ascites that was refractory to conservative management. All 3 patients (1 previously reported) underwent intranodal lymphangiography, followed by thoracic duct embolization, with 1 patient undergoing additional sclerosis of the retroperitoneal abdominal lymphatics...
March 7, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29497802/tracer-uptake-in-mediastinal-and-paraaortal-thoracic-lymph-nodes-as-a-potential-pitfall-in-image-interpretation-of-psma-ligand-pet-ct
#13
Ali Afshar-Oromieh, Lars Peter Sattler, Katja Steiger, Tim Holland-Letz, Marcelo Livorsi da Cunha, Walter Mier, Oliver Neels, Klaus Kopka, Wilko Weichert, Uwe Haberkorn
PURPOSE: Since the introduction of 68 Ga-PSMA-11 PET/CT for imaging prostate cancer (PC) we have frequently observed mediastinal lymph nodes (LN) showing tracer uptake despite being classified as benign. The aim of this evaluation was to further analyze such LN. METHODS: Two patient groups with biphasic 68 Ga-PSMA-11 PET/CT at 1 h and 3 h p.i. were included in this retrospective evaluation. Group A (n = 38) included patients without LN metastases, and group B (n = 43) patients with LN metastases of PC...
March 1, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29454438/therapeutic-lymphangiography-for-traumatic-chylothorax
#14
Hisako Hara, Makoto Mihara, Masayoshi Yamamoto
Chylothorax is a challenging disease. We present a case of traumatic chylothorax that was successfully treated using lymphangiography through intranodal injection of contrast agent. A 17-year-old girl had chylothorax. It did not improve despite medical treatment. We performed lymphangiography through intranodal injection of an oil contrast agent (Lipiodol). The amount of chylothorax was reduced from 1000 to 120 mL/d, and we could remove the thoracotomy tube. Thereafter, although she had a small amount of pleural effusion, she has not demonstrated aggravation for 19 months...
March 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29446846/histological-immune-response-patterns-in-sentinel-lymph-nodes-involved-by-metastatic-melanoma-and-prognostic-significance
#15
James Abbott, Meghan Buckley, Laura A Taylor, George Xu, Giorgos Karakousis, Brian J Czerniecki, Phyllis A Gimotty, Paul J Zhang
BACKGROUND: To further characterize the micromorphometric immunological pattern to metastatic melanoma in sentinel lymph node (SLN) biopsies and completion lymph node (CLN) dissections and their relation to 5-year overall survival (OS). METHODS: Retrospective cohort of 49 patients from 1996 to 2005 with a positive SLN who underwent CLN dissection (CLD) was studied. Micromorphometric characteristics included follicular center count (FCC)/profile, sinus histiocytosis, metastatic size, tumor infiltrating lymphocytes (intranodal), paracortical dendritic cells, germinal center reaction and morphology...
February 15, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29417265/embolization-of-the-thoracic-duct-by-direct-injection-of-n-butyl-2-cyanoacrylate-glue-via-a-puncture-needle
#16
Masayoshi Yamamoto, Kentaro Yamada, Masahiro Horikawa, Hiroshi Kondo, Hiroshi Oba, Shigeru Furui
PURPOSE: To report embolization of the thoracic duct by direct injection of N-butyl-2-cyanoacrylate (NBCA) glue via a puncture needle. MATERIALS AND METHODS: Two cases of high output chylothorax were successfully treated with direct injection of N-butyl-2-cyanoacrylate (NBCA) glue via a puncture needle. In them, conventional thoracic duct embolization (TDE) was attempted, but the cisterna chyli was absent on intranodal lymphangiography, and probably for this reason catheterization of the thoracic duct was unsuccessful...
February 7, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29397837/-expression-and-clinical-prognostical-significance-of-rip2-in-diffuse-large-b-cell-lymphoma
#17
Xin-Chen Wang, Kai-Yang Ding, Xiao-Qiu Wang, Zhi-Hua Wang, Jue Wang
OBJECTIVE: To investigate the expression and prognosis significance of receptor interacting protein 2 (RIP2) in diffuse large B-cell lymphoma (DLBCL). METHODS: The expression of RIP2 in DLBCL GCB and non-GCB type was detected by immunohistochemistry, at same time the expressions of BCL-2 and C-MYC were detected. Then, the role of RIP2 in development of DLBCL was analyzed by related clinical and pathological parameters. RESULTS: The expression of RIP2 was related with middle-high risk group by IPI score, the An Arbor stage III+IV and intranodal lesions, and the differences were statistically significant (P<0...
February 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29392400/extranodal-extension-of-nodal-metastases-is-a-poor-prognostic-moderator-in-non-small-cell-lung-cancer-a-meta-analysis
#18
Claudio Luchini, Nicola Veronese, Alessia Nottegar, Monica Cheng, Takuma Kaneko, Camilla Pilati, Fabrizio Tabbò, Brendon Stubbs, Antonio Pea, Fabio Bagante, Jacopo Demurtas, Matteo Fassan, Maurizio Infante, Liang Cheng, Aldo Scarpa
Extranodal extension (ENE) of nodal metastasis is defined as the extension of metastatic cells through the nodal capsule into the perinodal tissue. This morphological parameter, recently proposed as an important prognostic factor in different types of malignancy, has not been included in the TNM staging system for non-small cell lung cancer (NSCLC). In this systematic review with meta-analysis, we weighted the prognostic role of ENE in patients with lymph node-positive NSCLC. Two independent authors searched SCOPUS and PubMed through 28 February 2017...
February 1, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29343196/plexiform-vasculopathy-in-feline-cervical-lymph-nodes
#19
Nicole Jungwirth, Johannes Junginger, Christoph Andrijczuk, Wolfgang Baumgärtner, Peter Wohlsein
Plexiform vasculopathy refers to an endothelial proliferative disorder affecting cervical or inguinal lymph nodes of cats. The cause of this disorder and the origin of the proliferating endothelial cells are still unknown. In 4 cats with a history of a slowly growing, well-demarcated, nonpainful mass adjacent to the thyroid gland, an enlarged dark brown to red lymph node was removed. Histologically, the lymph nodes showed severe loss of lymphoid tissue with accumulations of erythrocytes. In addition, networks of capillary structures with well-differentiated endothelial cells on a collagen-rich stroma were observed, consistent with benign plexiform vasculopathy...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29225986/intranodal-palisaded-myofibroblastoma-in-a-submandibular-lymph-node
#20
Leila Bouhajja, Raja Jouini, Olfa Khayat, Wafa Koubâa, Chiraz Mbarek, Ehsen Ben Brahim, Achraf Chedly-Debbiche
Intranodal palisaded myofibroblastoma (IPM), also known as "intranodal hemorrhagic spindle cell tumor with amianthoid fibers," is a rare benign mesenchymal tumor originating from smooth muscle cells and myofibroblasts, often with the presence of amianthoid fibers. Usually IPM affects inguinal lymph nodes, but three cases have been described in the submandibular and cervical lymph nodes. We report a new case of a 44-year-old women with submandibular mass. Cervical ultrasound showed a suspect right submandibular adenomegaly...
2017: Case Reports in Otolaryngology
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