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JOURNAL ARTICLE
Satomi Sugiyama, Toshinori Iwai, Senri Oguri, Kenji Mitsudo
No abstract text is available yet for this article.
April 2024: Journal of Dental Sciences
#2
JOURNAL ARTICLE
Youhua Zhang
Background: A jump in the atrioventricular (AV) conduction curve is the current clinical criterion of dual-pathway electrophysiology. However, the assumption that a jump indicates a switch from fast pathway (FP) to slow pathway (SP) conduction remains unconfirmed. This study was carried out to investigate whether a jump indeed indicates a transition from FP to SP conduction, and if not, what the potential cause is. Methods: Eighty-one experimental records from rabbit AV nodal preparations containing the following data were analyzed: 1) had at least one AV conduction curve and 2) had recording of His electrogram alternans (a validated new index of dual-pathway conduction)...
2024: Frontiers in Physiology
#3
JOURNAL ARTICLE
Xavier Liem, Thierry de Baère, Omar I Vivar, Tanguy Y Seiwert, Colette Shen, Zsuzsanna Pápai, Victor Moreno, Zoltán Takácsi-Nagy, Frigyes Helferich, Juliette Thariat, Zhen Gooi, Sue S Yom, Paolo Bossi, Robert L Ferris, Trevor G Hackman, Christophe Le Tourneau, Joseph Rodriguez, Caroline Hoffmann
BACKGROUND: An international multidisciplinary panel of experts aimed to provide consensus guidelines describing the optimal intratumoral and intranodal injection of NBTXR3 hafnium oxide nanoparticles in head and neck squamous cell carcinoma (HNSCC) of the oral cavity, oropharynx, and cervical lymph nodes and to review data concerning safety, feasibility, and procedural aspects of administration. METHODS: The Delphi method was used to determine consensus. A 4-member steering committee and a 10-member monitoring committee wrote and revised the guidelines, divided into eight sections...
April 10, 2024: Head & Neck
#4
Yonglu Che, Curtis Chong, Marketa Limova, Laura Morris, Sunil Arani Reddy, Anne Lynn S Chang
No abstract text is available yet for this article.
April 2024: JAAD Case Reports
#5
JOURNAL ARTICLE
Diede Houbaert, Apostolos Panagiotis Nikolakopoulos, Kathryn A Jacobs, Odeta Meçe, Jana Roels, Gautam Shankar, Madhur Agrawal, Sanket More, Maarten Ganne, Kristine Rillaerts, Louis Boon, Magdalena Swoboda, Max Nobis, Larissa Mourao, Francesca Bosisio, Niels Vandamme, Gabriele Bergers, Colinda L G J Scheele, Patrizia Agostinis
Lymphatic endothelial cells (LECs) of the lymph node (LN) parenchyma orchestrate leukocyte trafficking and peripheral T cell dynamics. T cell responses to immunotherapy largely rely on peripheral T cell recruitment in tumors. Yet, a systematic and molecular understanding of how LECs within the LNs control T cell dynamics under steady-state and tumor-bearing conditions is lacking. Intravital imaging combined with immune phenotyping shows that LEC-specific deletion of the essential autophagy gene Atg5 alters intranodal positioning of lymphocytes and accrues their persistence in the LNs by increasing the availability of the main egress signal sphingosine-1-phosphate...
March 28, 2024: Cell Reports
#6
JOURNAL ARTICLE
Guang-Hui Lai, Jin-Jun Yue
Chimonobambusafarcta , a new species of temperate woody bamboos from western Guangxi, China is described and illustrated. The new species is similar to C.pubescens in the solid internodes of culms, but differs in having taller culm to 7 m with longer verrucose internodes to 23.5 cm and intranodes to 4 mm, intranode usually with a ring of 7-9 root thorns below mid-culm, abaxially brown or brown-purple verrucose-setose culm leaf sheaths with indistinct transverse veins, conspicuously developed culm leaf blades to 3...
2024: PhytoKeys
#7
JOURNAL ARTICLE
Hiroshi Fukushima, Aki Furusawa, Seiichiro Takao, Siddharth S Matikonda, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Peter L Choyke, Martin J Schnermann, Hisataka Kobayashi
BACKGROUND: Noninvasive in vivo cell tracking is valuable in understanding the mechanisms that enhance anti-cancer immunity. We have recently developed a new method called phototruncation-assisted cell tracking (PACT), that uses photoconvertible cell tracking technology to detect in vivo cell migration. This method has the advantages of not requiring genetic engineering of cells and employing tissue-penetrant near-infrared light. METHODS: We applied PACT to monitor the migration of immune cells between a tumour and its tumour-draining lymph node (TDLN) after near-infrared photoimmunotherapy (NIR-PIT)...
March 14, 2024: EBioMedicine
#8
JOURNAL ARTICLE
Soo Jin Woo, Saebeom Hur, Hee Seung Kim, Hak Chang, Ji-Young Kim, Soo Jin Park, Ung Sik Jin
Refractory chylous ascites can cause significant nutritional and immunologic morbidity, but no clear treatment has been established. This article introduces a case of a 22-year-old female patient with an underlying lymphatic anomaly who presented with refractory chylous ascites after laparoscopic adnexectomy for ovarian teratoma which aggravated after thoracic duct embolization. Ascites (>3,000 mL/d) had to be drained via a percutaneous catheter to relieve abdominal distention and consequent dyspnea, leading to significant cachexia and weight loss...
January 2024: Archives of Plastic Surgery
#9
Shota Higami, Yusuke Tanaka, Daisuke Maeda, Hiroshi Yukimoto, Tomomi Ishii, Yasuhiko Shiki
Lymphatic ascites is a postoperative complication of lymph node dissection. Most symptomatic cases improve with conservative treatments. However, optimal management strategies for intractable lymphatic ascites remain controversial, and clinicians sometimes encounter intractable lymphatic ascites that does not respond to conservative management. We herein report a case of postoperative intractable lymphatic ascites that was successfully treated with intranodal lymphangiography (LG) from inguinal lymph nodes under microsurgery...
April 2024: Gynecologic Oncology Reports
#10
JOURNAL ARTICLE
Kalijn F Bol, Gerty Schreibelt, Martine Bloemendal, Wouter W van Willigen, Simone Hins-de Bree, Anna L de Goede, Annemiek J de Boer, Kevin J H Bos, Tjitske Duiveman-de Boer, Michel A M Olde Nordkamp, Tom G M van Oorschot, Carlijn J Popelier, Jeanne M Pots, Nicole M Scharenborg, Mandy W M M van de Rakt, Valeska de Ruiter, Wilmy S van Meeteren, Michelle M van Rossum, Sandra J Croockewit, Bouke J Koeneman, Jeroen H A Creemers, Inge M N Wortel, Caroline Angerer, Mareke Brüning, Katja Petry, Andrzej Dzionek, Astrid A van der Veldt, Dirk J van Grünhagen, Johanna E M Werner, Johannes J Bonenkamp, John B A G Haanen, Marye J Boers-Sonderen, Rutger H T Koornstra, Martijn F Boomsma, Erik H J Aarntzen, Martin Gotthardt, James Nagarajah, Theo J M de Witte, Carl G Figdor, Johannes H W de Wilt, Johannes Textor, Jan Willem B de Groot, Winald R Gerritsen, I Jolanda M de Vries
Autologous natural dendritic cells (nDCs) treatment can induce tumor-specific immune responses and clinical responses in cancer patients. In this phase III clinical trial (NCT02993315), 148 patients with resected stage IIIB/C melanoma were randomized to adjuvant treatment with nDCs (n = 99) or placebo (n = 49). Active treatment consisted of intranodally injected autologous CD1c+ conventional and plasmacytoid DCs loaded with tumor antigens. The primary endpoint was the 2-year recurrence-free survival (RFS) rate, whereas the secondary endpoints included median RFS, 2-year and median overall survival, adverse event profile, and immunological response The 2-year RFS rate was 36...
February 23, 2024: Nature Communications
#11
JOURNAL ARTICLE
Q Gomes de Pinho, J-P Dales, N Macagno, F Houser, T Delayre, I Imbert-Joscht, P Rossi, A Benyamine, B Granel
INTRODUCTION: Lymphadenopathies are a major cause of consultation in internal medicine, with various causes of diagnosis. Unexplained persistent lymphadenopathy must be biopsied to rule out malignant tumor. CASE REPORT: We report the case of a 53-year-old man, with inguinal lymphadenopathy evolving for more than one year. The patient had no associated symptoms and his blood tests were unremarkable. Due to the progression of the adenopathy and its hypermetabolism on PET-CT, an excisional biopsy was performed...
February 22, 2024: La Revue de Médecine Interne
#12
JOURNAL ARTICLE
Vidushi Rathi
Dear Editor, The recent study by Madan et al. provides valuable information on the utility of intranodal cryobiopsy or forceps to endobronchial ultrasound - transbronchial needle aspiration during sampling of mediastinal lymph nodes...
February 19, 2024: Monaldi Archives for Chest Disease
#13
Taiga Oka, Hideki Ishimaru, Maki Hirao, Hiroki Nagayama, Shuto Miyamura, Chika Somagawa, Takashi Nonaka, Takuya Honda, Ryo Toya
A 40-year-old woman underwent laparoscopic common iliac lymphadenectomy for metastasis from rectal cancer. Two weeks after the surgery, she was found to have massive chylous ascites. After failure of conservative treatment, bilateral inguinal intranodal lymphangiography was performed. No definite extravasation was observed while lipiodol injected through the left inguinal node was ascending. When we punctured the right inguinal lymph nodes and started the injection of lipiodol, extravasation of diluted lipiodol was noted at the level of the first sacrum...
January 2024: BJR Case Reports
#14
JOURNAL ARTICLE
Tiago Paulino Torres, Pedro Costa, Herculano Moreira, Teresa Dionísio, Pedro Sousa
Thoracic duct embolization has been increasingly adopted as a first-line therapy of chylothorax and this procedure includes lipiodol lymphangiography, thoracic duct access and embolization. Lymphangiography itself has a therapeutic role, with volume-dependent success rates of 37%-97% and even a reported 100% success rate in outputs of < 500 mL/day. We present a clinical case of a 48-years-old man diagnosed with esophageal squamous cell carcinoma, who underwent esophagectomy and presented with post-operative high-output (> 1L/day) chylothorax; thoracic duct embolization was proposed...
February 9, 2024: Port J Card Thorac Vasc Surg
#15
REVIEW
Zi-Zhan Li, Nian-Nian Zhong, Lei-Ming Cao, Ze-Min Cai, Yao Xiao, Guang-Rui Wang, Bing Liu, Chun Xu, Lin-Lin Bu
Immunotherapy has emerged as a potent strategy in cancer treatment, with many approved drugs and modalities in the development stages. Despite its promise, immunotherapy is not without its limitations, including side effects and suboptimal efficacy. Using nanoparticles (NPs) as delivery vehicles to target immunotherapy to lymph nodes (LNs) can improve the efficacy of immunotherapy drugs and reduce side effects in patients. In this context, this paper reviews the development of LN-targeted immunotherapeutic NP strategies, the mechanisms of NP transport during LN targeting, and their related biosafety risks...
February 7, 2024: Small
#16
Rosa Bock, Peter Molony, Brendan Conn
This report describes a rare case of primary intranodal Warthin-like mucoepidermoid carcinoma (WL-MEC) presenting as a left level II lymph node mass in a 48-year-old man. Warthin-like mucoepidermoid carcinoma is a recently defined variant of MEC that bears a close histologic resemblance to Warthin tumor. Whereas MEC has readily identifiable key histologic features that render diagnosis relatively straightforward, WL-MEC is a challenging diagnosis due to overlapping histologic features and only limited case reports in the literature...
December 3, 2023: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
#17
JOURNAL ARTICLE
Jing Chen, Zhibin Huang, Hui Luo, Guoqiu Li, Zhimin Ding, Hongtian Tian, Shuzhen Tang, Sijie Mo, Jinfeng Xu, Huaiyu Wu, Fajin Dong
BACKGROUND: The application of photoacoustic imaging (PAI), utilizing laser-induced ultrasound, shows potential in assessing blood oxygenation in breast nodules. However, its effectiveness in distinguishing between malignant and benign nodules remains insufficiently explored. PURPOSE: This study aims to develop nomogram models for predicting the benign or malignant nature of breast nodules using PAI. METHOD: A prospective cohort study enrolled 369 breast nodules, subjecting them to PAI and ultrasound examination...
January 26, 2024: Postgraduate Medical Journal
#18
JOURNAL ARTICLE
Toshiyuki Nakai, Yuji Matsumoto, Takahiro Ueda, Yuko Kuwae, Sayaka Tanaka, Atsushi Miyamoto, Yoshiya Matsumoto, Kenji Sawa, Kanako Sato, Kazuhiro Yamada, Tetsuya Watanabe, Kazuhisa Asai, Hideaki Furuse, Keigo Uchimura, Tatsuya Imabayashi, Riki Uenishi, Mitsuru Fukui, Hidenori Tanaka, Masahiko Ohsawa, Tomoya Kawaguchi, Takaaki Tsuchida
BACKGROUND AND OBJECTIVE: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a diagnostic procedure with adequate performance; however, its ability to provide specimens of sufficient quality and quantity for treatment decision-making in advanced-stage lung cancer may be limited, primarily due to blood contamination. The use of a 0.96-mm miniforceps biopsy (MFB) permits true histological sampling, but the resulting small specimens are unsuitable for the intended applications...
January 21, 2024: Respirology: Official Journal of the Asian Pacific Society of Respirology
#19
JOURNAL ARTICLE
Manu Madan, A J Mahendran, Rohit Kumar, Yash Kedia, Rajnish Kaushik, Pranav Ish, Shibdas Chakrabarti, Neeraj Kumar Gupta, Nitesh Gupta
Endobronchial ultrasound (EBUS) guided mediastinal cryobiopsy, and intranodal forceps biopsy are newer modalities for sampling mediastinal lymph nodes. The data regarding the diagnostic yield of both modalities is scarce. Patients were recruited retrospectively from our existing database. Patients who had undergone both an EBUS guided mediastinal cryobiopsy and an intranodal forceps biopsy were enrolled in the study. The final diagnosis was made with a clinical-pathological-radiological assessment and clinico-radiological follow-up after one month...
January 15, 2024: Monaldi Archives for Chest Disease
#20
Alejandra C Vásquez-Castillo, Justin Moreira, Jesus E Guarecuco Castillo, Feisal Hamam, Mohammed M Masri
Lymphangiomas are benign deformities of the lymphatic system that are most common in pediatric populations and are usually found in the neck, axilla, chest wall, cervicofacial, and pelvic regions, as they are areas with more lymphatic activity. Herein, we report the case of a 43-year-old African-American male who presented with bilateral inguinal lymphangiomas, the first documented incidence of its kind. This patient presented with several months of bilateral swellings in his groin area, accompanied by increased tenderness and discomfort...
December 2023: Curēus
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