Zachary J Fennel, Paul-Emile Bourrant, Anu Susan Kurian, Jonathan J Petrocelli, Naomi M M P de Hart, Elena M Yee, Sihem Boudina, Hans S Keirstead, Gabrielle Nistor, Scott A Greilach, Nicole C Berchtold, Thomas E Lane, Micah J Drummond
Aging coincides with the progressive loss of muscle mass and strength, increased adiposity, and diminished physical function. Accordingly, interventions aimed at improving muscle, metabolic, and/or physical health are of interest to mitigate the adverse effects of aging. In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth, cytoskeletal remodeling, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22-24 months) compared to saline-injected aged-matched controls...
March 18, 2024: Aging Cell