keyword
MENU ▼
Read by QxMD icon Read
search

adipose remodeling

keyword
https://www.readbyqxmd.com/read/28222242/obesity-and-melanoma-could-fat-be-fueling-malignancy
#1
REVIEW
Emily Clement, Ikrame Lazar, Catherine Muller, Laurence Nieto
Over the last decade, it has become increasingly clear that adipose tissue, and particularly adipocytes, contribute to tumor progression. Obesity, an ever-increasing worldwide phenomenon, exacerbates this effect. The influence of obesity on melanoma remains poorly studied, although recent data does underline an association between the two diseases in both humans and murine models. Herein, we review the impact of obesity on melanoma incidence and progression and discuss the underlying mechanisms known to be involved...
February 21, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28219105/effects-of-resistance-training-volume-on-mmps-in-circulation-muscle-and-adipose-tissue
#2
Ivo Vieira de Sousa Neto, Ramires Alsamir Tibana, Dahan da Cunha Nascimento, Denis César Leite Vieira, Joao Luiz Quagliotti Durigan, Guilherme Borges Pereira, James Wilfred Navalta, Rita de Cássia Marqueti, Jonato Prestes
The aim of this study was to investigate the effects of different resistance training (RT) volumes on MMP activity in skeletal muscle, visceral adipose tissue and circulation. 21 Wistar rats were randomly divided into 3 groups (n=7 per group): sedentary control (SC); RT with 4 ladder climbs (RT-4; 50, 75, 90 and 100% of their maximal carrying capacity) and RT with 8 ladder climbs (RT-8 with 2 sets for each load). The 8-week RT consisted of climbing a 1.1-m vertical ladder with weights secured to the animals' tails...
February 20, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28215843/a-pdgfr%C3%AE-mediated-switch-toward-cd9-high-adipocyte-progenitors-controls-obesity-induced-adipose-tissue-fibrosis
#3
Geneviève Marcelin, Adaliene Ferreira, Yuejun Liu, Michael Atlan, Judith Aron-Wisnewsky, Véronique Pelloux, Yair Botbol, Marc Ambrosini, Magali Fradet, Christine Rouault, Corneliu Hénégar, Jean-Sébastien Hulot, Christine Poitou, Adriana Torcivia, Raphael Nail-Barthelemy, Jean-Christophe Bichet, Emmanuel L Gautier, Karine Clément
Obesity-induced white adipose tissue (WAT) fibrosis is believed to accelerate WAT dysfunction. However, the cellular origin of WAT fibrosis remains unclear. Here, we show that adipocyte platelet-derived growth factor receptor-α-positive (PDGFRα(+)) progenitors adopt a fibrogenic phenotype in obese mice prone to visceral WAT fibrosis. More specifically, a subset of PDGFRα(+) cells with high CD9 expression (CD9(high)) originates pro-fibrotic cells whereas their CD9(low) counterparts, committed to adipogenesis, are almost completely lost in the fibrotic WAT...
February 9, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28213979/mmp-2-and-mmp-14-silencing-inhibits-vegfr2-cleavage-and-induces-the-differentiation-of-porcine-adipose-derived-mesenchymal-stem-cells-to-endothelial-cells
#4
Sami G Almalki, Yovani Llamas Valle, Devendra K Agrawal
The molecular mechanisms that control the ability of adipose-derived mesenchymal stem cells (AMSCs) to remodel three-dimensional extracellular matrix barriers during differentiation are not clearly understood. Herein, we studied the expression of matrix metalloproteinases (MMPs) during the differentiation of AMSCs to endothelial cells (ECs) in vitro. MSCs were isolated from porcine abdominal adipose tissue, and characterized by immunopositivity to CD44, CD90, CD105, and immunonegativity to CD14 and CD45. Plasticity of AMSCs was confirmed by multilineage differentiation...
February 18, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28194185/osteopontin-relation-between-adipose-tissue-and-bone-homeostasis
#5
REVIEW
Carolina De Fusco, Antonietta Messina, Vincenzo Monda, Emanuela Viggiano, Fiorenzo Moscatelli, Anna Valenzano, Teresa Esposito, Chieffi Sergio, Giuseppe Cibelli, Marcellino Monda, Giovanni Messina
Osteopontin (OPN) is a multifunctional protein mainly associated with bone metabolism and remodeling. Besides its physiological functions, OPN is implicated in the pathogenesis of a variety of disease states, such as obesity and osteoporosis. Importantly, during the last decades obesity and osteoporosis have become among the main threats to health worldwide. Because OPN is a protein principally expressed in cells with multifaceted effects on bone morphogenesis and remodeling and because it seems to be one of the most overexpressed genes in the adipose tissue of the obese contributing to osteoporosis, this mini review will highlight recent insights about relation between adipose tissue and bone homeostasis...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28185267/regulation-of-adipose-tissue-derived-stromal-cell-orientation-and-motility-in-2d-and-3d-cultures-by-direct-current-electrical-field
#6
Gang Yang, Haiyan Long, Xiaomei Ren, Kunlong Ma, Zhenghua Xiao, Ying Wang, Yingqiang Guo
Cell alignment and motility play a critical role in a variety of cell behaviors, including cytoskeleton reorganization, membrane-protein relocation, nuclear gene expression, and extracellular matrix remodeling. Direct current electric field (EF) in vitro can direct many types of cells to align vertically to EF vector. In this work, we investigated the effects of EF stimulation on rat adipose-tissue-derived stromal cells (ADSCs) in 2D-culture on plastic culture dishes and in 3D-culture on various scaffold materials, including collagen hydrogels, chitosan hydrogels and poly(L-lactic acid)/gelatin electrospinning fibers...
February 10, 2017: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/28183844/association-between-posterior-left-atrial-adipose-tissue-mass-and-atrial-fibrillation
#7
Alexander R van Rosendael, Aukelien C Dimitriu-Leen, Philippe J van Rosendael, Melissa Leung, Jeff M Smit, Antti Saraste, Juhani Knuuti, Rob J van der Geest, Britt W H van der Arend, Erik W van Zwet, Arthur J Scholte, Victoria Delgado, Jeroen J Bax
BACKGROUND: Epicardial adipose tissue located close to the atrial wall can change the electric conduction of the left atrium, potentially leading to atrial fibrillation (AF). The aim of this study was to assess whether an increased atrial adipose tissue mass posterior to the left atrium is related to AF independent of demographical and cardiovascular risk factors. METHODS AND RESULTS: Two hundred patients with AF and 200 patients without AF who underwent computed tomographic angiography were included...
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28178530/lipidomic-adaptations-in-white-and-brown-adipose-tissue-in-response-to-exercise-demonstrate-molecular-species-specific-remodeling
#8
Francis J May, Lisa A Baer, Adam C Lehnig, Kawai So, Emily Y Chen, Fei Gao, Niven R Narain, Liubov Gushchina, Aubrey Rose, Andrea I Doseff, Michael A Kiebish, Laurie J Goodyear, Kristin I Stanford
Exercise improves whole-body metabolic health through adaptations to various tissues, including adipose tissue, but the effects of exercise training on the lipidome of white adipose tissue (WAT) and brown adipose tissue (BAT) are unknown. Here, we utilize MS/MS(ALL) shotgun lipidomics to determine the molecular signatures of exercise-induced adaptations to subcutaneous WAT (scWAT) and BAT. Three weeks of exercise training decrease specific molecular species of phosphatidic acid (PA), phosphatidylcholines (PC), phosphatidylethanolamines (PE), and phosphatidylserines (PS) in scWAT and increase specific molecular species of PC and PE in BAT...
February 7, 2017: Cell Reports
https://www.readbyqxmd.com/read/28156060/the-power-of-fat-and-its-adipose-derived-stromal-cells-emerging-concepts-for-fibrotic-scar-treatment
#9
REVIEW
Maroesjka Spiekman, Joris A van Dongen, Joep C Willemsen, Delia L Hoppe, Berend van der Lei, Martin C Harmsen
Lipofilling or lipografting is a novel and promising treatment method for reduction or prevention of dermal scars after injury. Ample anecdotal evidence from case reports supports the scar-reducing properties of adipose tissue grafts. However, only a few properly controlled and designed clinical trials have been conducted thus far on this topic. Also, the underlying mechanism by which lipofilling improves scar aspect and reduces neuropathic scar pain remains largely undiscovered. Adipose-derived stromal or stem cells (ADSC) are often described to be responsible for this therapeutic effect of lipofilling...
February 3, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28153949/factors-associated-with-left-atrial-remodeling-in-the-general-population
#10
Walter Oliver, Gwendolyn Matthews, Colby R Ayers, Sonia Garg, Sachin Gupta, Ian J Neeland, Mark H Drazner, Jarett D Berry, Susan Matulevicius, James A de Lemos
BACKGROUND: Although contributors to remodeling of the left ventricle (LV) have been well studied in general population cohorts, few data are available describing factors influencing changes in left atrial (LA) structure. METHODS AND RESULTS: Maximum LA volume was determined by cardiac magnetic resonance imaging among 748 participants in the Dallas Heart Study at 2 visits a mean of 8 years apart. Associations of changes in LA volume (ΔLAV) with traditional risk factors, biomarkers, LV geometry, and remodeling by cardiac magnetic resonance imaging and detailed measurements of global and regional adiposity (by magnetic resonance imaging and dual-energy x ray absorptiometry) were assessed using multivariable linear regression...
February 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28150299/role-of-pvat-on-coronary-atherosclerosis-and-vein-graft-patency-friend-or-foe
#11
REVIEW
M S Fernández Alfonso, M Gil-Ortega, I Aranguez, D Souza, M Dreifaldt, B Somoza, M R Dashwood
Perivascular adipose tissue (PVAT) releases multiple factors and adipokines with paracrine effects on both vascular structure and function. This influence is variable depending on regional differences in PVAT among blood vessels and with changes in adiposity. Considerable evidence demonstrates the association between coronary PVAT and the development and progression of coronary artery disease, associated with inflammation, oxidative stress, angiogenesis, vascular remodeling and blood clotting. However, PVAT also has a protective role on vascular grafts, especially the no-touch saphenous vein, in patients undergoing coronary artery bypass...
February 1, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28141918/pro-fibrotic-infrapatellar-fat-pad-remodeling-without-m1-macrophage-polarization-precedes-knee-osteoarthritis-in-diet-induced-obese-mice
#12
Erika Barboza, Joanna Hudson, Wan-Pin Chang, Susan Kovats, Rheal A Towner, Robert Silasi-Mansat, Florea Lupu, Collin Kent, Timothy M Griffin
OBJECTIVE: To test the hypothesis that high-fat (HF) diet-induced obesity increases pro-inflammatory cytokine expression, macrophage infiltration and M1 polarization in the infrapatellar fat pad (IFP) prior to knee cartilage degeneration. METHODS: We characterized the effect of HF feeding on knee OA pathology, body adiposity, and glucose intolerance in male C57BL/6J mice and identified a diet duration that induces metabolic dysfunction prior to cartilage degeneration...
January 31, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28131896/quercetin-a-functional-compound-of-onion-peel-remodels-white-adipocytes-to-brown-like-adipocytes
#13
Sang Gil Lee, John S Parks, Hye Won Kang
Adipocyte browning is a promising strategy for obesity prevention. Using onion-peel-derived extracts and their bioactive compounds, we demonstrate that onion peel, a by-product of onion, can change the characteristics of white adipocytes to those of brown-like adipocytes in the white adipose tissue of mice and 3T3-L1 cells. The expression of the following brown adipose tissue-specific genes was increased in the retroperitoneal and subcutaneous adipose tissues of 0.5% onion-peel-extract-fed mice: PR domain-containing 16, peroxisome proliferator-activated receptor gamma coactivator 1α, uncoupling protein 1, fibroblast growth factor 21 and cell death-inducing DFFA-like effector...
January 12, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28123942/fetal-development-of-subcutaneous-white-adipose-tissue-is-dependent-on-zfp423
#14
Mengle Shao, Chelsea Hepler, Lavanya Vishvanath, Karen A MacPherson, Napoleon C Busbuso, Rana K Gupta
OBJECTIVE: Zfp423 is a multi zinc-finger transcription factor expressed in preadipocytes and mature adipocytes in vivo. Our recent work has revealed a critical role for Zfp423 in maintaining the fate of white adipocytes in adult mice through suppression of the beige cell thermogenic gene program; loss of Zfp423 in mature adipocytes of adult mice results in a white-to-beige phenotypic switch. However, the exact requirements of Zfp423 in the fetal stages of early adipose development in vivo have not been clarified...
January 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28123139/remodeling-of-rat-stromal-vascular-cells-to-brite-beige-adipocytes-by-prolyl-hydroxyproline
#15
Jun A Minaguchi, Sakino Ogata, Naoki Takahashi, Takuya Hirose, Hiromi Ueda, Kazushige Takehana
The aim of this study was to determine the effects of prolyl-hydroxyproline (Pro-Hyp) on the proliferation and differentiation of rat stromal-vascular cells (SVCs) being cultured in a medium with (Pro-Hyp group) or without Pro-Hyp (control group). The results showed that there was no significant difference in proliferation rate of SVCs, lipid droplet (LD) diameter or intracellular concentration of triglycerides between two groups. However, the diameter range of LDs in the Pro-Hyp group tended to be smaller than that in the control group...
January 26, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28122789/pdgfr%C3%AE-regulates-adipose-tissue-expansion-and-glucose-metabolism-via-vascular-remodeling-in-diet-induced-obesity
#16
Yasuhiro Onogi, Tsutomu Wada, Chie Kamiya, Kento Inata, Takatoshi Matsuzawa, Yuka Inaba, Kumi Kimura, Hiroshi Inoue, Seiji Yamamoto, Yoko Ishii, Daisuke Koya, Hiroshi Tsuneki, Masakiyo Sasahara, Toshiyasu Sasaoka
Platelet-derived growth factor (PDGF) is a key factor of angiogenesis; however, its role in adult obesity remains unclear. In order to clarify its pathophysiological role, we investigated the significance of a PDGF receptor β on adipose tissue expansion and glucose metabolism. Mature vessels in the epididymal white adipose tissue (eWAT) were tightly wrapped with pericytes in normal mice. Pericytes desorption from vessels and the subsequent proliferations of endothelial cells were markedly increased in the eWAT of diet-induced obese mice...
January 25, 2017: Diabetes
https://www.readbyqxmd.com/read/28116726/isolation-and-differentiation-of-human-macrophages
#17
Francisco J Rios, Rhian M Touyz, Augusto C Montezano
Macrophage subtypes display protective or pathogenic activities in vascular lesions. They recognize and engulf modified lipids, accumulate in the arterial intima, contributing to the atherosclerosis development. In the heart, vascular tissues and perivascular adipose tissues, there is increasing evidence that macrophages play a role in endothelial dysfunction, vascular inflammation and remodeling. In this chapter we describe protocols to isolate human monocytes from peripheral blood mononuclear cell and how to differentiate them into macrophages by using growth factors (granulocyte-macrophage colony-stimulating factor-GM-CSF or colony-stimulating factor-M-CSF) or by different cell culture medium concentration...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28116725/isolation-and-differentiation-of-murine-macrophages
#18
Francisco J Rios, Rhian M Touyz, Augusto C Montezano
Macrophages play a major role in inflammation, wound healing, and tissue repair. Infiltrated monocytes differentiate into different macrophage subtypes with protective or pathogenic activities in vascular lesions. In the heart and vascular tissues, pathological activation promotes cardiovascular inflammation and remodeling and there is increasing evidence that macrophages play important mechanisms in this environment. Primary murine macrophages can be obtained from: bone marrow by different treatments (granulocyte-macrophage colony-stimulating factor-GM-CSF, macrophage colony-stimulating factor-M-CSF or supernatant of murine fibroblast L929), peritoneal cavity (resident or thioglycolate elicit macrophages), from the lung (alveolar macrophages) or from adipose tissue...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28110302/atrial-fibrillation-beyond-the-arrhythmia-hypercoagulability-adipose-tissue-and-fibrotic-remodelling
#19
Thomas F Lüscher
No abstract text is available yet for this article.
January 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28100772/de-novo-sphingolipid-biosynthesis-is-required-for-adipocyte-survival-and-metabolic-homeostasis
#20
Aikaterini Alexaki, Benjamin A Clarke, Oksana Gavrilova, Yinyan Ma, Hongling Zhu, Xinran Ma, Lingyan Xu, Galina Tuymetova, Bridget C Larman, Maria L Allende, Teresa M Dunn, Richard L Proia
Sphingolipids are a diverse class of essential cellular lipids that function as structural membrane components and as signaling molecules. Cells acquire sphingolipids by both de novo biosynthesis and recycling of exogenous sphingolipids. The individual importance of these pathways for the generation of essential sphingolipids in differentiated cells is not well understood. To investigate the requirement for de novo sphingolipid biosynthesis in adipocytes, a cell type with highly regulated lipid metabolism, we generated mice with an adipocyte-specific deletion of Sptlc1 Sptlc1 is an obligate subunit of serine palmitoyltransferase, the enzyme responsible for the first and rate-limiting step of de novo sphingolipid biosynthesis...
January 18, 2017: Journal of Biological Chemistry
keyword
keyword
93501
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"