keyword
https://read.qxmd.com/read/38542113/cell-based-therapies-for-rotator-cuff-injuries-an-updated-review-of-the-literature
#1
REVIEW
Nicholas Hooper, Anuj Marathe, Nitin B Jain, Prathap Jayaram
This review focuses on non-surgical treatment options for rotator cuff injuries and highlights the potential of mesenchymal stem cells (MSCs) as a potential regenerative approach. MSCs, sourced from various tissues like bone marrow and adipose tissue, exhibit promising mechanisms in vitro, influencing tendon-related gene expression and microenvironment modulation. Animal studies support this, showcasing MSCs' ability to reduce inflammation, improve tissue remodeling, and enhance repaired tendon strength. Human trials, while varied and limited, suggest that MSCs might lower retear rates and enhance post-repair outcomes, but randomized controlled trials yield mixed results, emphasizing the necessity for standardized investigations...
March 8, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38540717/comparison-between-the-regenerative-and-therapeutic-impacts-of-bone-marrow-mesenchymal-stem-cells-and-adipose-mesenchymal-stem-cells-pre-treated-with-melatonin-on-liver-fibrosis
#2
JOURNAL ARTICLE
Ahmed Elzainy, Abir El Sadik, Waleed Mohammad Altowayan
BACKGROUND: The distinctive feature of liver fibrosis is the progressive replacement of healthy hepatic cells by the extracellular matrix protein, which is abundant in collagen I and III, with impaired matrix remodeling. The activation of myofibroblastic cells enhances the fibrogenic response of complex interactions of hepatic stellate cells, fibroblasts, and inflammatory cells to produce the excessive deposition of the extracellular protein matrix. This process is activated by multiple fibrogenic mediators and cytokines, such as TNF-α and IL-1β, accompanied with a decrease in the anti-fibrogenic factor NF-κβ...
March 1, 2024: Biomolecules
https://read.qxmd.com/read/38537739/the-impact-of-chemotherapy-on-adipose-tissue-remodeling-the-molecular-players-involved-in-this-tissue-wasting
#3
REVIEW
Samuel Barbosa, Mafalda Barbosa Pedrosa, Rita Ferreira, Daniel Moreira-Gonçalves, Lúcio Lara Santos
The depletion of visceral and subcutaneous adipose tissue (AT) during chemotherapy significantly correlates with diminished overall survival and progression-free survival. Despite its clinical significance, the intricate molecular mechanisms governing this AT loss and its chemotherapy-triggered initiation remain poorly understood. Notably, the evaluation of AT remodeling in most clinical trials has predominantly relied on computerized tomography scans or bioimpedance, with molecular studies often conducted using animal or in vitro models...
March 25, 2024: Biochimie
https://read.qxmd.com/read/38509584/pdgfr%C3%AE-%C3%A2-%C3%A2-cell-hif2%C3%AE-is-dispensable-for-white-adipose-tissue-metabolic-remodeling-and-hepatic-lipid-accumulation-in-obese-mice
#4
JOURNAL ARTICLE
Tao Yao, Danni Wei, Xin Tian, Lin Zhao, Qiangyou Wan, Xiaoli Zhang, Juan Cai, Siqi Li, Bowen Diao, Suihan Feng, Bo Shan, Mengle Shao, Ying Wu
BACKGROUND: Obesity is associated with extensive white adipose tissue (WAT) expansion and remodeling. Healthy WAT expansion contributes to the maintenance of energy balance in the liver, thereby ameliorating obesity-related hepatic steatosis. Tissue-resident mesenchymal stromal cell populations, including PDGFRβ + perivascular cells, are increasingly recognized pivotal as determinants of the manner in which WAT expands. However, the full array of regulatory factors controlling WAT stromal cell functions remains to be fully elucidated...
March 20, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38507414/the-zebrafish-heart-harbors-a-thermogenic-beige-fat-depot-analog-of-human-epicardial-adipose-tissue
#5
JOURNAL ARTICLE
Paul-Andres Morocho-Jaramillo, Ilan Kotlar-Goldaper, Bhakti I Zakarauskas-Seth, Bettina Purfürst, Alessandro Filosa, Suphansa Sawamiphak
Epicardial adipose tissue (eAT) is a metabolically active fat depot that has been associated with a wide array of cardiac homeostatic functions and cardiometabolic diseases. A full understanding of its diverse physiological and pathological roles is hindered by the dearth of animal models. Here, we show, in the heart of an ectothermic teleost, the zebrafish, the existence of a fat depot localized underneath the epicardium, originating from the epicardium and exhibiting the molecular signature of beige adipocytes...
March 18, 2024: Cell Reports
https://read.qxmd.com/read/38504370/dapagliflozin-promotes-white-adipose-tissue-browning-though-regulating-angiogenesis-in-high-fat-induced-obese-mice
#6
JOURNAL ARTICLE
Lin Xiang, Min Liu, Guangda Xiang, Ling Yue, Junxia Zhang, Xiaoli Xu, Jing Dong
Browning of white adipose tissue (WAT) is become an appealing target for therapeutics in the treatment of obesity and related metabolic diseases. Dapagliflozin is widely used in the treatment of type 2 diabetes, and it is also found that the drug exhibits regulate systemic metabolism such as obesity, insulin resistance and hepatic steatosis. However, the precise role of dapagliflozin on WAT remodeling remains to be elucidated. The current study aimed to explore the role of dapagliflozin on WAT browning in high-fat diet (HFD)-induced obese mice...
March 19, 2024: BMC Pharmacology & Toxicology
https://read.qxmd.com/read/38502318/quality-of-epicardial-adipose-tissue-predicts-major-adverse-cerebral-and-cardiovascular-events-following-transcatheter-aortic-valve-implantation
#7
JOURNAL ARTICLE
Takaaki Sato, Kunio Yufu, Hirochika Yamasaki, Taisuke Harada, Shuichiro Yamauchi, Yumi Ishii, Tomoko Fukuda, Takayuki Kawashima, Takashi Shuto, Hidefumi Akioka, Tetsuji Shinohara, Yasushi Teshima, Tomoyuki Wada, Shinji Miyamoto, Naohiko Takahashi
Epicardial adipose tissue (EAT) have been shown to be associated with several heart disease, including coronary artery disease (CAD), atrial fibrillation (AF), and heart failure (HF). It is reported that the quality of EAT, represented by fat attenuation determined using computed tomography (CT) imaging, can detect the histologically-assessed remodeled EAT. We tested the hypothesis that quality of EAT would predict major adverse cerebral and cardiovascular events (MACCE) following transcatheter aortic valve implantation (TAVI) in patients with aortic stenosis (AS)...
March 19, 2024: Heart and Vessels
https://read.qxmd.com/read/38500398/stem-cell-secretome-treatment-improves-whole-body-metabolism-reduces-adiposity-and-promotes-skeletal-muscle-function-in-aged-mice
#8
JOURNAL ARTICLE
Zachary J Fennel, Paul-Emile Bourrant, Anu Susan Kurian, Jonathan J Petrocelli, Naomi M M P de Hart, Elena M Yee, Sihem Boudina, Hans S Keirstead, Gabrielle Nistor, Scott A Greilach, Nicole C Berchtold, Thomas E Lane, Micah J Drummond
Aging coincides with the progressive loss of muscle mass and strength, increased adiposity, and diminished physical function. Accordingly, interventions aimed at improving muscle, metabolic, and/or physical health are of interest to mitigate the adverse effects of aging. In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth, cytoskeletal remodeling, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22-24 months) compared to saline-injected aged-matched controls...
March 18, 2024: Aging Cell
https://read.qxmd.com/read/38498418/nanomodulator-mediated-restructuring-of-adipose-tissue-immune-microenvironments-for-antiobesity-treatment
#9
JOURNAL ARTICLE
Qiaoyun Li, Junho Byun, Jaehyun Choi, Jinwon Park, Jaiwoo Lee, Yu-Kyoung Oh
In obesity, the interactions between proinflammatory macrophages and adipocytes in white adipose tissues are known to play a crucial role in disease progression by providing inflammatory microenvironments. Here, we report that the functional nanoparticle-mediated modulation of crosstalk between adipocytes and macrophages can remodel adipocyte immune microenvironments. As a functional nanomodulator, we designed antivascular cell adhesion molecule (VCAM)-1 antibody-conjugated and amlexanox-loaded polydopamine nanoparticles (VAPN)...
March 18, 2024: ACS Nano
https://read.qxmd.com/read/38488044/moderate-intensity-combined-training-induces-lipidomic-changes-in-individuals-with-obesity-and-type-2-diabetes
#10
JOURNAL ARTICLE
Renata Garbellini Duft, Ivan Luiz Padilha Bonfante, Susana Alejandra Palma-Duran, Mara Patrícia Traina Chacon-Mikahil, Julian Leether Griffin, Cláudia Regina Cavaglieri
CONTEXT: Alterations in the lipid metabolism are linked to metabolic disorders such as insulin resistance (IR), obesity and type 2 diabetes (T2D). Regular exercise, particularly combined training (CT), is a well-known non-pharmacological treatment that combines aerobic (AT) and resistance (RT) training benefits. However, it is unclear whether moderate-intensity exercise without dietary intervention induces changes in lipid metabolism to promote a 'healthy lipidome'. OBJECTIVE: The study aimed to investigate the effect of 16 weeks of CT on plasma and white adipose tissue in both sexes, middle-aged subjects with normal weight, obesity and T2D using an ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) untargeted lipidomics approach...
March 15, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38481287/global-gene-expression-profiling-of-perirenal-brown-adipose-tissue-whitening-in-goat-kids-reveals-novel-genes-linked-to-adipose-remodeling
#11
JOURNAL ARTICLE
Le Zhao, Haili Yang, Minhao Li, Min Xiao, Xingchun Li, Lei Cheng, Wenqiang Cheng, Meixi Chen, Yongju Zhao
BACKGROUND: Brown adipose tissue (BAT) is known to be capable of non-shivering thermogenesis under cold stimulation, which is related to the mortality of animals. In the previous study, we observed that goat BAT is mainly located around the kidney at birth, and changes to white adipose tissue (WAT) in the perirenal adipose tissue of goats within one month after birth. However, the regulatory factors underlying this change is remain unclear. In this study, we systematically studied the perirenal adipose tissue of goat kids in histological, cytological, and accompanying molecular level changes from 0 to 28 d after birth...
March 14, 2024: Journal of Animal Science and Biotechnology
https://read.qxmd.com/read/38480743/intestinal-dual-specificity-phosphatase-6-regulates-the-cold-induced-gut-microbiota-remodeling-to-promote-white-adipose-browning
#12
JOURNAL ARTICLE
Pei-Chen Chen, Tzu-Pei Tsai, Yi-Chu Liao, Yu-Chieh Liao, Hung-Wei Cheng, Yi-Hsiu Weng, Chiao-Mei Lin, Cheng-Yuan Kao, Chih-Cheng Tai, Jhen-Wei Ruan
Gut microbiota rearrangement induced by cold temperature is crucial for browning in murine white adipose tissue. This study provides evidence that DUSP6, a host factor, plays a critical role in regulating cold-induced gut microbiota rearrangement. When exposed to cold, the downregulation of intestinal DUSP6 increased the capacity of gut microbiota to produce ursodeoxycholic acid (UDCA). The DUSP6-UDCA axis is essential for driving Lachnospiraceae expansion in the cold microbiota. In mice experiencing cold-room temperature (CR) transitions, prolonged DUSP6 inhibition via the DUSP6 inhibitor (E/Z)-BCI maintained increased cecal UDCA levels and cold-like microbiota networks...
March 13, 2024: NPJ Biofilms and Microbiomes
https://read.qxmd.com/read/38480481/impact-of-epicardial-adipose-tissue-on-cardiac-function-and-morphology-in-patients-with-diastolic-dysfunction
#13
JOURNAL ARTICLE
Alexander Schulz, Sören J Backhaus, Torben Lange, Ruben Evertz, Shelby Kutty, Johannes T Kowallick, Gerd Hasenfuß, Andreas Schuster
AIMS: This study aimed to identify the impact of increased epicardial adipose tissue (EAT) and its regional distribution on cardiac function in patients with diastolic dysfunction. METHODS AND RESULTS: Sixty-eight patients with exertional dyspnoea (New York Heart Association ≥II), preserved ejection fraction (≥50%), and diastolic dysfunction (E/e' ≥ 8) underwent rest and stress right heart catheterization, transthoracic echocardiography, and cardiovascular magnetic resonance (CMR)...
March 13, 2024: ESC Heart Failure
https://read.qxmd.com/read/38474251/the-efficacy-of-stem-cells-in-wound-healing-a-systematic-review
#14
REVIEW
Banu Farabi, Katie Roster, Rahim Hirani, Katharine Tepper, Mehmet Fatih Atak, Bijan Safai
Wound healing is an intricate process involving coordinated interactions among inflammatory cells, skin fibroblasts, keratinocytes, and endothelial cells. Successful tissue repair hinges on controlled inflammation, angiogenesis, and remodeling facilitated by the exchange of cytokines and growth factors. Comorbid conditions can disrupt this process, leading to significant morbidity and mortality. Stem cell therapy has emerged as a promising strategy for enhancing wound healing, utilizing cells from diverse sources such as endothelial progenitor cells, bone marrow, adipose tissue, dermal, and inducible pluripotent stem cells...
March 5, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38468962/3d-printed-polycaprolactone-%C3%AE-tricalcium-phosphate-carbon-nanotube-composite-physical-properties-and-biocompatibility
#15
JOURNAL ARTICLE
Yuelei Wang, Chenjing Liu, Tao Song, Zhenlu Cao, Ting Wang
Three-dimensional (3D) printing is a bio-fabrication technique used to process tissue-engineered scaffolds for bone repair and remodeling. Polycaprolactone (PCL)/β-tricalcium phosphate (TCP) has been used as a base and osteoconductive biomaterial for bone tissue engineering in the past decades. The current study reveals the fabrication of a polycaprolactone (PCL)/β-tricalcium phosphate (TCP) scaffold by incorporating carbon nanotubes (CNT) via 3D printing. The physical properties and cytocompatibility of a new type of tissue engineering composite from polycaprolactone/β-tri-calcium phosphate/carbon nanotubes were investigated, and it was an absorbable scaffold prepared via furnace deposition 3D printing technology...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38460909/the-pathophysiology-of-visceral-adipose-tissues-in-cardiometabolic-diseases
#16
REVIEW
Mi-Jeong Lee, Jeehoon Kim
Central pattern of fat distribution, especially fat accumulation within the intraabdominal cavity increases risks for cardiometabolic diseases. Portal hypothesis combined with a pathological remodeling in visceral fat is considered the major etiological factor explaining the independent contribution of visceral obesity to cardiometabolic diseases. Excessive remodeling in visceral fat during development of obesity leads to dysfunctions in the depot, characterized by hypertrophy and death of adipocytes, hypoxia, inflammation, and fibrosis...
March 8, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38459259/role-of-il-18-in-adipose-tissue-remodeling-and-metabolic-dysfunction
#17
JOURNAL ARTICLE
Jaqueline Pereira Lana, Marina Chaves de Oliveira, Ana Letícia Malheiros Silveira, Letícia Tamie Paiva Yamada, Kátia Anunciação Costa, Simone Vargas da Silva, Agatha de Assis-Ferreira, Emmanuel L Gautier, Sébastien Dussaud, Vanessa Pinho, Mauro Martins Teixeira, Geneviève Marcelin, Karine Clément, Adaliene Versiani Matos Ferreira
BACKGROUND/OBJECTIVES: Proinflammatory cytokines are increased in obese adipose tissue, including inflammasome key masters. Conversely, IL-18 protects against obesity and metabolic dysfunction. We focused on the IL-18 effect in controlling adipose tissue remodeling and metabolism. MATERIALS/SUBJECTS AND METHODS: We used C57BL/6 wild-type (WT) and interleukine-18 deficient (IL-18-/- ) male mice fed a chow diet and samples from bariatric surgery patients. RESULTS: IL-18-/- mice showed increased adiposity and proinflammatory cytokine levels in adipose tissue, leading to glucose intolerance...
March 8, 2024: International Journal of Obesity
https://read.qxmd.com/read/38458567/adipose-tissue-peroxisomal-lipid-synthesis-orchestrates-obesity-and-insulin-resistance-through-lxr-dependent-lipogenesis
#18
JOURNAL ARTICLE
Brian Kleiboeker, Anyuan He, Min Tan, Dongliang Lu, Donghua Hu, Xuejing Liu, Parniyan Goodarzi, Fong-Fu Hsu, Babak Razani, Clay F Semenkovich, Irfan J Lodhi
Adipose tissue mass is maintained by a balance between lipolysis and lipid storage. The contribution of adipose lipogenesis to fat mass, especially in the setting of high-fat feeding, is considered minor. Here, we report that adipose-specific knockout of the peroxisomal lipid synthetic protein PexRAP promotes diet-induced obesity and insulin resistance through activation of de novo lipogenesis. PexRAP inactivation inhibits the flux of carbons to ethanolamine plasmalogens. This increases nuclear PC/PE ratio and promotes cholesterol mislocalization, resulting in the activation of liver X receptor (LXR), a nuclear receptor known to be activated by increased intracellular cholesterol...
March 6, 2024: Molecular Metabolism
https://read.qxmd.com/read/38456486/macrophages-play-a-nutritive-role-in-post-metamorphic-maturation-in-drosophila
#19
JOURNAL ARTICLE
Gabriela Krejčová, Adéla Danielová, Hana Sehadová, Filip Dyčka, Jiří Kubásek, Martin Moos, Adam Bajgar
In the body of multicellular organisms, macrophages play an indispensable role in maintaining tissue homeostasis by removing old, apoptotic and damaged cells. In addition, macrophages allow significant remodeling of body plans during embryonic morphogenesis, regeneration and metamorphosis. Although the huge amount of organic matter that must be removed during these processes represents a potential source of nutrients, their further utilization by the organism has not yet been addressed. Here, we document that during metamorphosis, Drosophila larval adipose tissue is infiltrated by macrophages, which remove dying adipocytes by efferocytosis and engulf leaking RNA-protein granules and lipids...
March 8, 2024: Development
https://read.qxmd.com/read/38455105/crosstalk-between-wnt-and-bone-morphogenetic-protein-signaling-during-osteogenic-differentiation
#20
REVIEW
Pakkath Narayanan Arya, Iyyappan Saranya, Nagarajan Selvamurugan
Mesenchymal stem cells (MSCs) originate from many sources, including the bone marrow and adipose tissue, and differentiate into various cell types, such as osteoblasts and adipocytes. Recent studies on MSCs have revealed that many transcription factors and signaling pathways control osteogenic development. Osteogenesis is the process by which new bones are formed; it also aids in bone remodeling. Wnt/β-catenin and bone morphogenetic protein (BMP) signaling pathways are involved in many cellular processes and considered to be essential for life...
February 26, 2024: World Journal of Stem Cells
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