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https://www.readbyqxmd.com/read/29236236/the-co-evolution-of-bullying-perpetration-homophobic-teasing-and-a-school-friendship-network
#1
Gabriel J Merrin, Kayla de la Haye, Dorothy L Espelage, Brett Ewing, Joan S Tucker, Matthew Hoover, Harold D Green
Bullying and homophobic teasing behaviors affect the lives of many school aged children, often co-occur, and tend to peak in middle school. While bullying and homophobic teasing behaviors are known to be peer group phenomena, studies typically examine the associations at the individual or school levels. An examination of these behaviors at the peer group level can aid in our understanding of the formation and maintenance of peer groups that engage in these forms of aggressive behavior (selection), and the extent to which friends and the peer group impact individual rates of these aggressive behaviors (influence)...
December 13, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/29236228/population-pharmacokinetic-pharmacodynamic-modeling-of-ropivacaine-in-spinal-anesthesia
#2
Zoubir Djerada, Catherine Feliu, Yoann Cazaubon, Faouzi Smati, Philippe Gomis, Dominique Guerrot, Beny Charbit, Olivier Fernandes, Jean-Marc Malinovsky
BACKGROUND: Ropivacaine is frequently used in spinal anesthesia but the relationship between plasma concentrations and sensory block level remains unknown. OBJECTIVE: The aim of this study was to assess the relationship between plasma ropivacaine concentrations and effects during spinal anesthesia. METHODS: Sixty patients aged between 18 and 82 years were included in this study after providing written informed consent. Patients were randomly assigned to receive intrathecal administration of ropivacaine 15, 20 or 25 mg...
December 13, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29236034/gastric-emptying-and-gastrointestinal-transit-compared-among-native-and-hydrolyzed-whey-and-casein-milk-proteins-in-an-aged-rat-model
#3
Julie E Dalziel, Wayne Young, Catherine M McKenzie, Neill W Haggarty, Nicole C Roy
Little is known about how milk proteins affect gastrointestinal (GI) transit, particularly for the elderly, in whom digestion has been observed to be slowed. We tested the hypothesis that GI transit is faster for whey than for casein and that this effect is accentuated with hydrolysates, similar to soy. Adult male rats (18 months old) were fed native whey or casein, hydrolyzed whey (WPH) or casein (CPH), hydrolyzed blend (HB; 60% whey:40% casein), or hydrolyzed soy for 14 days then treated with loperamide, prucalopride, or vehicle-control for 7 days...
December 13, 2017: Nutrients
https://www.readbyqxmd.com/read/29235986/managing-diabetes-in-people-with-dementia-a-realist-review
#4
Frances Bunn, Claire Goodman, Peter Reece Jones, Bridget Russell, Daksha Trivedi, Alan Sinclair, Antony Bayer, Greta Rait, Jo Rycroft-Malone, Chris Burton
BACKGROUND: Dementia and diabetes mellitus are common long-term conditions that coexist in a large number of older people. People living with dementia and diabetes may be at increased risk of complications such as hypoglycaemic episodes because they are less able to manage their diabetes. OBJECTIVES: To identify the key features or mechanisms of programmes that aim to improve the management of diabetes in people with dementia and to identify areas needing further research...
December 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29235659/effect-of-metabolic-syndrome-on-late-life-depression-associations-with-disease-severity-and-treatment-resistance
#5
John S Mulvahill, Ginger E Nicol, David Dixon, Eric J Lenze, Jordan F Karp, Charles F Reynolds, Daniel M Blumberger, Benoit H Mulsant
BACKGROUND/OBJECTIVES: Metabolic syndrome (MetS) is the co-occurrence of obesity and metabolic derangements. Prior research implicates MetS in prolongation of the course of depression in older adults, but its effect on antidepressant response is unknown in this population. The objective was to determine whether MetS and related metabolic dyscrasias are associated with decreased rate of remission from depression in older adults treated pharmacologically for depression. DESIGN: Secondary analysis of a randomized controlled trial...
December 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29235432/impact-of-informal-caregiving-on-cognitive-function-and-well-being-in-canada
#6
Sasha Mallya, Alexandra J Fiocco
BACKGROUND: With a rise in the aging population and a consequential rise in persons diagnosed with dementia comes an increase in the number of informal caregivers who are caring for a loved one. The objective of the proposed study was to assess the neurocognitive and psychological effects of caring for a person with dementia or a related neurodegenerative disease in a sample of Canadian informal caregivers. METHODS: Fifty-seven informal caregivers of a person with dementia or a related neurodegenerative disease (mean age = 66...
December 13, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29235066/dysthyroidism-and-chronic-heart-failure-pathophysiological-mechanisms-and-therapeutic-approaches
#7
Caterina Rizzo, Margherita Ilaria Gioia, Giuseppe Parisi, Vincenzo Triggiani, Massimo Iacoviello
Among comorbidity in chronic heart failure (CHF), dysthyroidism represents a relevant problem especially in the ageing CHF patients worldwide. Thyroid greatly affects many cardiovascular activities and its dysfunction may worsen a CHF condition. In particular, hypothyroidism has a relative high prevalence in patients with heart failure and it plays a key role in influencing CHF onset, progression and prognosis. Hyperthyroidism, is less frequent in this clinical context but it necessitates of immediate treatment because of its negative effects on cardiovascular balance...
December 13, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29235013/effects-of-weight-loss-on-acoustic-parameters-after-bariatric-surgery
#8
Lourdes Bernadete Rocha de Souza, Marquiony Marques Dos Santos, Leandro Araújo Pernambuco, Cynthia Meira de Almeida Godoy, Deysianne Meire da Silva Lima
BACKGROUND: Patients with morbid obesity may present vocal alterations, since large accumulation of fat in the vocal tract may interfere with voice production of these individuals. OBJECTIVE: Verify the neck circumference and the acoustic parameters of voice in obese women, before and after the bariatric surgery, and compare the results with a control group, with normal weight. METHODS: Observational, longitudinal, descriptive study with patients referred to the SCODE (Obesity Surgery and Related Disorders Center) in a university hospital...
December 12, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29234754/durability-of-resin-bonding-to-lithium-disilicate-and-zirconia-ceramic-using-a-self-etching-primer
#9
Sebastian Wille, Frank Lehmann, Matthias Kern
PURPOSE: The purpose of this in vitro study was twofold: 1. To evaluate the surface conditioning effect of a self-etching ceramic primer on lithium disilicate and zirconia ceramics; (2) to study the bond durability provided by the self-etching ceramic primer after artificial aging compared with conventional ceramic conditioning methods. MATERIALS AND METHODS: Lithium disilicate blocks (10 × 10 mm, 3.4 mm thick) and zirconia disks (8 mm diameter, 3.4 mm thick) were each divided into two groups...
December 12, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/29234603/a-retrospective-study-of-clinico-epidemiological-profile-of-snakebite-related-deaths-at-a-tertiary-care-hospital-in-midnapore-west-bengal-india
#10
Rituparna Ghosh, Koushik Mana, Kripasindhu Gantait, Sumana Sarkhel
Objective: Snakebite is one of the neglected tropical diseases that World Health Organization (WHO) aimed to eradicate. The objective of the study is to investigate the mortality and morbidity due to snakebite at Midnapore Medical College & Hospital in Paschim Medinipur district, West Bengal, India. Methods & materials: This is a record-based, retrospective, descriptive epidemiological study conducted from January 2012 to December 2016 at Midnapore Medical College and Hospital(MMCH), Paschim Medinipur district, West Bengal...
2018: Toxicology Reports
https://www.readbyqxmd.com/read/29234553/gait-deficits-under-dual-task-conditions-in-the-concussed-adolescent-and-young-athlete-population-a-systematic-review
#11
Larisa Grants, Bailey Powell, Cody Gessel, Faith Hiser, Amy Hassen
Background: There are no current sport concussion assessments that capture the effects of dual-task conditions on gait. Multiple studies have evaluated changes, but none have comprehensively examined literature related to the adolescent and young adult population.Purpose: The purpose of this systematic review is to synthesize documented changes in gait under dual-task conditions in adolescents and young adults after sustaining a concussion.Study Design: Systematic Review. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was consulted to guide this systematic review...
December 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/29234427/a-chinese-herbal-formula-gengnianchun-ameliorates-%C3%AE-amyloid-peptide-toxicity-in-a-caenorhabditis-elegans-model-of-alzheimer-s-disease
#12
Fanhui Meng, Jun Li, Yanqiu Rao, Wenjun Wang, Yan Fu
Alzheimer's disease (AD) is an age-related neurodegenerative disorder, and the few drugs that are currently available only treat the symptoms. Traditional medicine or phytotherapy has been shown to protect against AD. In our previous studies, Gengnianchun (GNC), a traditional Chinese medicine formula with a prolongevity effect, protected against Aβ-induced cytotoxicity in pheochromocytoma cells (PC-12 cells) and hippocampal cells. Here, we investigated the effects and possible mechanisms by which GNC protected against Aβ toxicity using transgenic Caenorhabditis elegans CL4176...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234364/eghb010-a-standardized-extract-of-paeoniae-radix-and-glycyrrhizae-radix-inhibits-vegf-induced-tube-formation-in-vitro-and-retinal-vascular-leakage-and-choroidal-neovascularization-in-vivo
#13
Eunsoo Jung, Wookwon Jung, Su-Bin Park, Chan-Sik Kim, Jin Sook Kim, Junghyun Kim
EGHB010 is a hot water extract of the rhizome mixture of Paeonia lactiflora Pallas and Glycyrrhiza uralensis Fisch. Choroidal neovascularization (CNV) and vascular leakage are the common pathophysiologies of age-related macular degeneration. In this study, we aimed to evaluate the effect of EGHB010 on retinal vascular leakage and laser-induced CNV in a rat model. Vascular endothelial growth factor- (VEGF-) induced tube formation was assayed in human retinal microvascular endothelial cells. Intravitreal VEGF-induced blood-retinal barrier breakdown was assayed in Sprague-Dawley rats...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234258/toxicity-adverse-events-and-quality-of-life-associated-with-the-treatment-of-metastatic-castration-resistant-prostate-cancer
#14
REVIEW
Senol Tonyali, Hakan Bahadir Haberal, Emrullah Sogutdelen
Objectives: Among males, prostate cancer (PCa) is the most common cancer in Europe and the second most common cancer worldwide, especially in those aged > 70 years. With the advent of novel alternative treatments, survival in patients with advanced PCa has increased. PCa is now considered a chronic disease. Survival is an important endpoint in advanced PCa, as is quality of life (QoL). The effects of the disease and its treatment on patient health-related QoL must be taken into account when selecting the most appropriate treatment options...
November 2017: Current Urology
https://www.readbyqxmd.com/read/29234058/relation-of-ultrasound-findings-and-abdominal-symptoms-obtained-with-the-cfabd-score-in-cystic-fibrosis-patients
#15
Harold Tabori, Anke Jaudszus, Christin Arnold, Hans-Joachim Mentzel, Michael Lorenz, Ruth K Michl, Thomas Lehmann, Diane M Renz, Jochen G Mainz
Abdominal symptoms are a hallmark of Cystic fibrosis (CF). Yet, their association with morphological abnormalities of different abdominal organs is still poorly understood. Aim was therefore to relate these symptoms, assessed with a questionnaire, to findings in abdominal ultrasound (US). In 114 CF patients of all ages, findings in US considering seventeen specific parameters were related to abdominal symptoms compiled with our novel CF-specific 26-modal symptom score (CFAbd-Score). US abnormalities were detected in 95% of the patients...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233802/how-when-and-why-people-seek-health-information-online-qualitative-study-in-hong-kong
#16
Joanna Tw Chu, Man Ping Wang, Chen Shen, Kasisomayajula Viswanath, Tai Hing Lam, Sophia Siu Chee Chan
BACKGROUND: The Internet has become an established source for health information. The number of individuals using the Internet to search for health information, ranging from healthy lifestyle advice to treatment and diseases, continues to grow. Scholars have emphasized the need to give greater voice and influence to health consumers. Hong Kong, being one of the most technologically advanced and connected cities in the world, has one of the highest Internet penetration rates in the world...
December 12, 2017: Interactive Journal of Medical Research
https://www.readbyqxmd.com/read/29233718/right-anterior-cerebellum-bold-responses-reflect-age-related-changes-in-simon-task-sequential-effects
#17
D Aisenberg, A Sapir, A Close, A Henik, G d'Avossa
Participants are slower to report a feature, such as color, when the target appears on the side opposite the instructed response, than when the target appears on the same side. This finding suggests that target location, even when task-irrelevant, interferes with response selection. This effect is magnified in older adults. Lengthening the inter-trial interval, however, suffices to normalize the congruency effect in older adults, by re-establishing young-like sequential effects (Aisenberg, Sapir, d'Avossa, Henik, 2014)...
December 9, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29233619/fto-affects-food-cravings-and-interacts-with-age-to-influence-age-related-decline-in-food-cravings
#18
Linh C Dang, Gregory R Samanez-Larkin, Christopher T Smith, Jaime J Castrellon, Scott F Perkins, Ronald L Cowan, Daniel O Claassen, David H Zald
The fat mass and obesity associated gene (FTO) was the first gene identified by genome-wide association studies to correlate with higher body mass index (BMI) and increased odds of obesity. FTO remains the locus with the largest and most replicated effect on body weight, but the mechanism whereby FTO affects body weight and the development of obesity is not fully understood. Here we tested whether FTO is associated with differences in food cravings and a key aspect of dopamine function that has been hypothesized to influence food reward mechanisms...
December 9, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29233604/axonal-excitability-changes-and-acute-symptoms-of-oxaliplatin-treatment-in-vivo-evidence-for-slowed-sodium-channel-inactivation
#19
Rikke Heide, Hugh Bostock, Lise Ventzel, Peter Grafe, Joseph Bergmans, Anders Fuglsang-Frederiksen, Nanna B Finnerup, Hatice Tankisi
OBJECTIVE: Neurotoxicity is the most frequent dose-limiting side effect of the anti-cancer agent oxaliplatin, but the mechanisms are not well understood. This study used nerve excitability testing to investigate the pathophysiology of the acute neurotoxicity. METHODS: Questionnaires, quantitative sensory tests, nerve conduction studies and nerve excitability testing were undertaken in 12 patients with high-risk colorectal cancer treated with adjuvant oxaliplatin and in 16 sex- and age-matched healthy controls...
November 26, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29233580/colorectal-carcinoma-in-the-frail-surgical-patient-implementation-of-a-work-area-focused-on-the-complex-surgical-patient-improves-postoperative-outcome
#20
Jordi Castellví Valls, Núria Borrell Brau, María José Bernat, Patricia Iglesias, Lluís Reig, Lluís Pascual, Marina Vendrell, Pilar Santos, Lorenzo Viso, Núria Farreres, Gonzalo Galofre, Carmen Deiros, Pedro Barrios
INTRODUCTION: Advanced age and comorbidity impact on post-operative morbi-mortality in the frail surgical patient. The aim of this study is to assess the impact of a comprehensive, multidisciplinary and individualized care delivered to the frail patient by implementation of a Work Area focused on the Complex Surgical Patient (CSPA). METHODS: Retrospective study with prospective data collection. Ninety one consecutive patients, classified as frail (ASAIII or IV, Barthel<80 and/or Pfeiffer>3) underwent curative radical surgery for colorectal carcinoma between 2013 and 2015...
December 9, 2017: Cirugía Española
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