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Relative age effect

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https://www.readbyqxmd.com/read/29045965/-cause-analysis-of-spinal-surgery-in-ankylosing-spondylitis
#1
R Liu, L Sun, C H Li, J Y Zhai, X Y Liu
OBJECTIVE: To investigate the common cause of spinal surgery in ankylosing spondylitis (AS) and to develop reasonable and effective treatment programs for rhematologists. METHODS: In this study, 79 AS patients (72 males, 7 females) hospitalized in the Department of Orthopedic and received spinal surgery in Peking University Third Hospital from January 2007 to July 2013 were investigated retrospectively. The causes of the spinal surgery were analyzed. RESULTS: The majority of the surgery were of cervical vertebra surgery for 59 cases (74...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045959/-prevalence-of-autism-spectrum-disorders-in-children-aged-0-6-years-in-china-a-meta-analysis
#2
H F Shi, J X Zhang, R Zhang, X L Wang
OBJECTIVE: To estimate the prevalence and trend of autism spectrum disorders (ASD) in children aged 0-6 years in China. METHODS: Systematic literature searches were conducted in PubMed, Web of Science, Scopus, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Wanfang and Weipu Database (VIP ), and the literatures published before February 25, 2017 were selected according to the same criteria. Prevalence Data of three periods were abstracted, then pooled using random effect model...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045958/-clinical-characteristics-of-glucocorticoid-induced-eye-adverse-reactions-in-children-with-primary-nephrotic-syndrome
#3
Y Zhao, B G Su, H J Xiao, H W Zhang, X Y Liu, F Wang, J Ding
OBJECTIVE: To investigate the clinical features and side effects, with regard to glucocorticoid-induced ocular hypertension, glaucoma or cataract in children with primary nephrotic syndrome. METHODS: Clinical data were collected and analyzed from 71 cases of primary nephrotic syndrome with glucocorticoid-induced ocular hypertension, glaucoma or cataract from Jun. 2014 to Jun. 2016. These children were hospitalized in Peking University First Hospital. RESULTS: Totally 1 580 children with primary nephrotic syndrome were collected, glucocorticoid-induced complications in eyes were found in 71 cases, and the incidence was 4...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045833/intestinal-fork-head-regulates-nutrient-absorption-and-promotes-longevity
#4
Ekin Bolukbasi, Mobina Khericha, Jennifer C Regan, Dobril K Ivanov, Jennifer Adcott, Miranda C Dyson, Tobias Nespital, Janet M Thornton, Nazif Alic, Linda Partridge
Reduced activity of nutrient-sensing signaling networks can extend organismal lifespan, yet the underlying biology remains unclear. We show that the anti-aging effects of rapamycin and reduced intestinal insulin/insulin growth factor (IGF) signaling (IIS) require the Drosophila FoxA transcription factor homolog Fork Head (FKH). Intestinal FKH induction extends lifespan, highlighting a role for the gut. FKH binds to and is phosphorylated by AKT and Target of Rapamycin. Gut-specific FKH upregulation improves gut barrier function in aged flies...
October 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/29045751/development-and-validation-of-a-multidimensional-intergenerational-relationship-quality-scale-for-aging-chinese-parents
#5
Xue Bai, Rachel Pruchno
Background and Objectives: The quality of intergenerational relationships is crucial for maintaining the well-being of parents and adult children. This study developed and validated an Intergenerational Relationship Quality Scale for Aging Chinese Parents (IRQS-AP) based on the solidarity, conflict, and ambivalence models. Research Design and Methods: The data were derived from a cross-sectional study in Hong Kong which included a random sample of 1,001 community-dwelling individuals aged ≥50 years...
October 17, 2017: Gerontologist
https://www.readbyqxmd.com/read/29045734/the-effect-of-aging-on-response-congruency-in-task-switching-a-meta-analysis
#6
James A Grange, Raymond B Becker, Nicole Anderson
Objectives: Response-congruency effects in task switching are the observed slowing of response times (RTs) for incongruent targets which afford more than one response (depending on task) in comparison to congruent stimuli that afford just one response regardless of the task. These effects are thought to reflect increased ambiguity during response selection for incongruent stimuli. Methods: The present study presents a meta-analysis of 27 conditions (from 16 separate studies) whose designs allowed investigation of age-related differences in response-congruency effects on RT...
October 16, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29045667/survey-of-reproductive-experiences-and-outcomes-of-cancer-survivors-who-stored-reproductive-material-before-treatment
#7
K Hammarberg, M Kirkman, C Stern, R I McLachlan, G Clarke, F Agresta, D Gook, L Rombauts, B Vollenhoven, J R W Fishe
STUDY QUESTION: What are the reproductive experiences and outcomes of people who store reproductive material before cancer treatment? SUMMARY ANSWER: Of respondents who had tried to achieve pregnancy since completing cancer treatment almost all had succeeded, in most cases through natural conception. WHAT IS KNOWN ALREADY: People of reproductive age who are diagnosed with cancer can cryopreserve reproductive material to guard against the adverse effects on fertility of gonadotoxic treatment...
October 17, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29045642/patient-and-tumor-characteristics-and-their-influence-on-early-therapy-persistence-with-letrozole-in-postmenopausal-patients-with-early-breast-cancer
#8
N Nabieva, S Kellner, T Fehm, L Häberle, J de Waal, M Rezai, B Baier, G Baake, H-C Kolberg, M Guggenberger, M Warm, N Harbeck, R Wuerstlein, J-U Deuker, P Dall, B Richter, G Wachsmann, C Brucker, J W Siebers, N Fersis, T Kuhn, C Wolf, H-W Vollert, G-P Breitbach, W Janni, R Landthaler, A Kohls, D Rezek, T Noesselt, G Fischer, S Henschen, T Praetz, V Heyl, T Kühn, T Krauss, C Thomssen, A Hohn, H Tesch, C Mundhenke, A Hein, C Rauh, C M Bayer, A Jacob, K Schmidt, E Belleville, S Y Brucker, S Kümmel, M W Beckmann, D Wallwiener, P Hadji, P A Fasching
Background: Patients' compliance and persistence with endocrine treatment has a significant effect on the prognosis in early breast cancer (EBC). The purpose of this analysis was to identify possible reasons for non-persistence, defined as premature cessation of therapy, on the basis of patient and tumor characteristics in individuals receiving adjuvant treatment with letrozole. Patients and methods: The EvAluate-TM Study is a prospective, multicenter, noninterventional study in which treatment with the aromatase inhibitor letrozole was evaluated in postmenopausal women with hormone receptor-positive EBC in the early therapy phase...
October 10, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045458/individual-differences-in-responsivity-to-social-rewards-insights-from-two-eye-tracking-tasks
#9
Bhismadev Chakrabarti, Anthony Haffey, Loredana Canzano, Christopher P Taylor, Eugene McSorley
Humans generally prefer social over nonsocial stimuli from an early age. Reduced preference for social rewards has been observed in individuals with autism spectrum conditions (ASC). This preference has typically been noted in separate tasks that measure orienting toward and engaging with social stimuli. In this experiment, we used two eye-tracking tasks to index both of these aspects of social preference in in 77 typical adults. We used two measures, global effect and preferential looking time. The global effect task measures saccadic deviation toward a social stimulus (related to 'orienting'), while the preferential looking task records gaze duration bias toward social stimuli (relating to 'engaging')...
2017: PloS One
https://www.readbyqxmd.com/read/29045326/the-effects-of-acute-interval-exercise-and-strawberry-intake-on-postprandial-lipemia
#10
Alasdair F O'Doherty, Huw S Jones, Thozhukat Sathyapalan, Lee Ingle, Sean Carroll
PURPOSE: Raised postprandial triglycerides (TAG) and related oxidative stresses are strongly associated with increased cardiovascular disease risk. Acute exercise and strawberry ingestion independently ameliorate postprandial lipid excursions and oxidative stress. However, the combined effects of these lifestyle interventions are unknown. We investigated whether acute exercise and strawberry consumption improved postprandial responses to an oral fat tolerance test (OFTT) in overweight/obese males...
November 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29045325/effects-of-two-years-of-calorie-restriction-on-aerobic-capacity-and-muscle-strength
#11
Susan B Racette, James Rochon, Mary L Uhrich, Dennis T Villareal, Sai Krupa DAS, Luigi Fontana, Manjushri Bhapkar, Corby K Martin, Leanne M Redman, Paul J Fuss, Susan B Roberts, William E Kraus
PURPOSE: Calorie restriction (CR) improves health span and delays age-related diseases in many species. The multicenter Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) study was the first randomized controlled trial of CR in nonobese humans. The aim of this investigation was to determine the effects of CR on V˙O2max and muscle strength in the CALERIE trial. METHODS: Healthy, normal-weight, and mildly overweight women and men (n = 218, mean ± SE age = 37...
November 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29045307/prevalence-of-antipsychotic-treated-patients-in-a-cohort-of-adult-addicted-patients
#12
Hélène Peyrière, Caroline Diot, Erika Nogue, Marie Verschave, Morgan Laure, Marie-Christine Picot, Pierre Petit, Hélène Donnadieu-Rigole, Yves Leglise
PURPOSE: The objective of this cross-sectional study was to describe and estimate the prevalence of antipsychotics (AP) in a cohort of addicted patients, and to compare the profiles of addictive patients receiving AP or not. METHODS: We included all adult patients seen at the addiction care center of Montpellier University Hospital, between January 1, 2015, and March 31, 2015. Demographic, clinical, and therapeutic data were collected from the patients' medical records...
October 17, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29045304/effect-of-clozapine-vs-other-second-generation-antipsychotics-on-hospitalization-and-seclusion-a-retrospective-mirror-image-study-in-a-japanese-public-psychiatric-hospital
#13
Fuminari Misawa, Takefumi Suzuki, Yasuo Fujii
BACKGROUND: Clozapine has been regarded as the gold standard for patients with treatment-resistant schizophrenia, but a recent network meta-analysis has questioned its relative superiority over other second-generation antipsychotics (SGAs) such as olanzapine and risperidone. PURPOSE: We conducted a retrospective mirror-image study of clozapine vs other SGAs to evaluate real-world effectiveness of clozapine in terms of the duration of hospitalization and seclusion, both of which represent a critical outcome...
October 17, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29045078/skin-tears-and-risk-factors-assessment-a-systematic-review-on-evidence-based-medicine
#14
Raffaele Serra, Nicola Ielapi, Andrea Barbetta, Stefano de Franciscis
Skin tears represent a common condition of traumatic wounds, which may be encountered in some categories of individuals at the extremes of age, such as infants and the elderly. Despite the high prevalence and cost of these lesions, there has been little investigation into the risk factors that lead to this condition. The aim of this review was to systematically evaluate the main risk factors involved in development of skin tears. We planned to include all the studies dealing with risk factors related to skin tears...
October 17, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29045001/anti-inflammaging-effects-of-human-alpha-1-antitrypsin
#15
Ye Yuan, Benedetto DiCiaccio, Ying Li, Ahmed S Elshikha, Denis Titov, Brian Brenner, Lee Seifer, Hope Pan, Nurdina Karic, Mohammad A Akbar, Yuanqing Lu, Sihong Song, Lei Zhou
Inflammaging plays an important role in most age-related diseases. However, the mechanism of inflammaging is largely unknown, and therapeutic control of inflammaging is challenging. Human alpha-1 antitrypsin (hAAT) has immune-regulatory, anti-inflammatory, and cytoprotective properties as demonstrated in several disease models including type 1 diabetes, arthritis, lupus, osteoporosis, and stroke. To test the potential anti-inflammaging effect of hAAT, we generated transgenic Drosophila lines expressing hAAT...
October 17, 2017: Aging Cell
https://www.readbyqxmd.com/read/29044863/identification-of-somatic-genetic-alterations-in-ovarian-clear-cell-carcinoma-with-next-generation-sequencing
#16
Yusuke Shibuya, Hideki Tokunaga, Sakae Saito, Kazurou Shimokawa, Fumiki Katsuoka, Li Bin, Kaname Kojima, Masao Nagasaki, Masayuki Yamamoto, Nobuo Yaegashi, Jun Yasuda
Ovarian clear cell carcinoma (OCCC) is the most refractory subtype of ovarian cancer and more prevalent in Japanese than Caucasians (25% and 5% of all ovarian cancer, respectively). The aim of this study is to discover the genomic alterations that may cause OCCC and effective molecular targets for chemotherapy. Paired genomic DNAs of 48 OCCC tissues and corresponding non-cancerous tissues were extracted from formalin-fixed, paraffin embedded specimens collected between 2007 and 2015 at Tohoku University Hospital...
October 16, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29044725/serum-sclerostin-levels-in-adults-with-osteogenesis-imperfecta-comparison-with-normal-individuals-and-response-to-teriparatide-therapy
#17
Lindsey Nicol, Ying Wang, Rosamund Smith, John Sloan, Sandesh C S Nagamani, Jay Shapiro, Brendan Lee, Eric Orwoll
Sclerostin (SOST), a glycoprotein primarily derived from osteocytes, is an important regulator of bone remodeling. Osteogenesis imperfecta ([1]) is a heritable disorder of bone characterized by low bone mass, bone fragility, recurrent fractures, and bone deformities. Altered SOST-mediated signaling may have a role in pathogenesis of type I collagen-related OI; however this has not been evaluated in humans. We measured serum SOST levels in adults with OI who were enrolled in a randomized, placebo-controlled clinical trial that evaluated the effects of osteoanabolic therapy with teriparatide...
October 17, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29044689/behead-and-live-long-or-the-tale-of-cathepsin-l
#18
Maria Karolin Streubel, Johannes Bischof, Richard Weiss, Jutta Duschl, Wolfgang Liedl, Herbert Wimmer, Michael Breitenbach, Manuela Weber, Florian Geltinger, Klaus Richter, Mark Rinnerthaler
In the last decades S. cerevisiae has proven to be one of the most valuable model organisms of aging research. Pathways as autophagy or the effect of substances like resveratrol and spermidine that prolong the replicative as well as chronological lifespan of cells have been described for the first time in S. cerevisiae. In this study we describe the establishment of an aging reporter that allows a reliable and relative quick screening of substances and genes that have an impact on the replicative lifespan. A cDNA library of the flatworm Dugesia tigrina that can be immortalized by beheading was screened using this aging reporter...
October 17, 2017: Yeast
https://www.readbyqxmd.com/read/29044639/inflammatory-pathology-markers-activated-microglia-and-reactive-astrocytes-in-early-and-late-onset-alzheimer-disease-a-post-mortem-study
#19
Ricardo Taipa, Vitor Ferreira, Paulo Brochado, Andrew Robinson, Inês Reis, Fernanda Marques, David M Mann, Manuel Melo Pires, Nuno Sousa
AIMS: The association between the pathological features of AD and dementia is stronger in younger old persons than in older old persons suggesting that additional factors are involved in the clinical expression of dementia in the oldest old. Cumulative data suggests that neuroinflammation plays a prominent role in Alzheimer's disease (AD) and different studies reported an age-associated dysregulation of the neuroimmune system. Consequently, we sought to characterize the pattern of microglial cell activation and astrogliosis in brain post-mortem tissue of pathologically confirmed cases of early and late onset AD (EOAD and LOAD) and determine their relation to age...
October 17, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29044613/effect-of-androgen-deprivation-therapy-on-the-contractile-properties-of-type-i-and-type-ii-skeletal-muscle-fibres-in-men-with-non-metastatic-prostate-cancer
#20
C R Lamboley, H Xu, T L Dutka, E D Hanson, A Hayes, J A Violet, R M Murphy, G D Lamb
The contractile properties of vastus lateralis muscle fibres were examined in prostate cancer (PrCa) patients undergoing androgen deprivation therapy (ADT) and in age- and activity-matched healthy male subjects (Control). Mechanically-skinned muscle fibres were exposed to a sequence of heavily Ca(2+) -buffered solutions at progressively higher free [Ca(2+) ] to determine their force-Ca(2+) relationship. Ca(2+) -sensitivity was decreased in both type I and type II muscle fibres of ADT subjects relative to Controls (by -0...
October 17, 2017: Clinical and Experimental Pharmacology & Physiology
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