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https://www.readbyqxmd.com/read/28445687/accuracy-of-low-dose-ct-in-the-diagnosis-of-appendicitis-in-childhood-and-comparison-with-usg-and-standard-dose-ct
#1
Dae Yong Yi, Kyung Hoon Lee, Sung Bin Park, Jee Taek Kim, Na Mi Lee, Hyery Kim, Sin Weon Yun, Soo Ahn Chae, In Seok Lim
OBJECTIVES: Computed tomography should be performed after careful consideration due to radiation hazard, which is why interest in low dose CT has increased recently in acute appendicitis. Previous studies have been performed in adult and adolescents populations, but no studies have reported on the efficacy of using low-dose CT in children younger than 10 years. METHODS: Patients (n=475) younger than 10 years who were examined for acute appendicitis were recruited...
April 23, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28445561/allegations-of-failure-to-obtain-informed-consent-in-spinal-surgery-medical-malpractice-claims
#2
Jennifer Grauberger, Panagiotis Kerezoudis, Asad J Choudhry, Mohammed Ali Alvi, Ahmad Nassr, Bradford Currier, Mohamad Bydon
Importance: Predictive factors associated with increased risk of medical malpractice litigation have been identified, including severity of injury, physician sex, and error in diagnosis. However, there is a paucity of literature investigating informed consent in spinal surgery malpractice. Objective: To investigate the failure to obtain informed consent as an allegation in medical malpractice claims for patients undergoing a spinal procedure. Design, Setting, and Participants: In this retrospective cohort study, a national medicolegal database was searched for malpractice claim cases related to spinal surgery for all years available (ie, January 1, 1980, through December 31, 2015)...
April 26, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28445501/out-of-hospital-cardiac-arrest-survival-in-drug-related-versus-cardiac-causes-in-ontario-a-retrospective-cohort-study
#3
Aaron M Orkin, Chun Zhan, Jason E Buick, Ian R Drennan, Michelle Klaiman, Pamela Leece, Laurie J Morrison
BACKGROUND: Drug overdose causes approximately 183,000 deaths worldwide annually and 50,000 deaths in Canada and the United States combined. Drug-related deaths are concentrated among young people, leading to a substantial burden of disease and loss of potential life years. Understanding the epidemiology, patterns of care, and prognosis of drug-related prehospital emergencies may lead to improved outcomes. METHODS: We conducted a retrospective cohort study of out-of-hospital cardiac arrests with drug-related and presumed cardiac causes between 2007 and 2013 using the Toronto Regional RescuNet Epistry database...
2017: PloS One
https://www.readbyqxmd.com/read/28445443/nutrimiraging-micromanaging-nutrient-sensing-pathways-through-nutrition-to-promote-healthy-aging
#4
REVIEW
Víctor Micó, Laura Berninches, Javier Tapia, Lidia Daimiel
Current sociodemographic predictions point to a demographic shift in developed and developing countries that will result in an unprecedented increase of the elderly population. This will be accompanied by an increase in age-related conditions that will strongly impair human health and quality of life. For this reason, aging is a major concern worldwide. Healthy aging depends on a combination of individual genetic factors and external environmental factors. Diet has been proved to be a powerful tool to modulate aging and caloric restriction has emerged as a valuable intervention in this regard...
April 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28445361/adolescent-desire-for-cosmetic-surgery-associations-with-bullying-and-psychological-functioning
#5
Kirsty Lee, Alexa Guy, Jeremy Dale, Dieter Wolke
BACKGROUND: Adolescent bullying may be a key driver of interest in cosmetic surgery. This study examined the extent of such interest and whether any effect was sex-specific, and examined psychological functioning as a potential mechanism through which bullying involvement may lead to a wish for cosmetic surgery. METHODS: A two-stage design was used. In the first stage, 2782 adolescents (aged 11 to 16 years) were screened for bullying involvement using self-reports and peer nominations...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28445286/remote-ischemic-preconditioning-improves-the-cognitive-function-of-elderly-patients-following-colon-surgery-a-randomized-clinical-trial
#6
Zhenqiu He, Nan Xu, Sihua Qi
BACKGROUND: Cognitive function impairment is one of the most common complications in elderly patients after surgery, and an ideal nonpharmacological therapy has not yet been identified. Thus, we hypothesized that remote ischemic preconditioning could improve cognitive functions in elderly patients after surgery and investigated the mechanism underlying this effect. METHODS: Ninety patients classified as American Society of Anaesthesiologists (ASA) physical status of 2 or 3 and aged 65 to 75 years who were scheduled for elective colon surgery under general anesthesia were randomly allocated to either a remote ischemic preconditioning group (Group R, n = 45) or a control group (Group C, n = 45)...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445237/effects-of-polymyxin-b-hemoperfusion-on-mortality-in-patients-with-severe-sepsis-and-septic-shock-a-systemic-review-meta-analysis-update-and-disease-severity-subgroup-meta-analysis
#7
Tzu Chang, Yu-Kang Tu, Chen-Tse Lee, Anne Chao, Chi-Hsiang Huang, Ming-Jiuh Wang, Yu-Chang Yeh
OBJECTIVE: Several studies have reported a survival benefit for polymyxin B hemoperfusion treatment in patients with severe sepsis and septic shock. However, recently, a propensity-matched analysis and a randomized controlled trial reported no survival benefit for polymyxin B hemoperfusion treatment. We performed an up-to-date meta-analysis to determine the effect of polymyxin B hemoperfusion treatment on mortality in patients with severe sepsis and septic shock. DATA SOURCES: PubMed, Embase, and Cochrane Library were searched from inception to May 2016...
April 25, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28445231/the-effects-of-multi-day-vs-single-pre-exercise-nitrate-supplement-dosing-on-simulated-cycling-time-trial-performance-and-skeletal-muscle-oxygenation
#8
Edward Jo, Michelle Fischer, Alexandra T Auslander, Alan Beigarten, Bruce Daggy, Ken Hansen, Lisa Kessler, Adam Osmond, Hong Wang, Rachel Wes
A transient augmentation in the metabolic efficiency of skeletal muscle is the purported basis for dietary nitrate supplementation amongst competitive and recreational athletes alike. Previous studies support the ergogenic effects of nitrate supplementation as findings indicated improved microvascular blood flow, exercise economy, and performance with relatively short-term supplementation. As with most ergogenic aids, the optimum duration of supplementation prior to performance or competition, i.e. loading phase, is a critical determinant for efficacy...
April 18, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28445229/a-cross-sectional-and-retrospective-cohort-analysis-of-the-effects-of-age-on-flexibility-strength-endurance-lower-body-power-and-aerobic-fitness-in-law-enforcement-officers
#9
Robert G Lockie, J Jay Dawes, Charles L Kornhauser, Ryan J Holmes
There can be a great age range in cohorts of law enforcement officers. As the tasks required of officers generally do not change with advancing age, it is important to understand how physical performance in tests that assess job-specific characteristics may be altered. Retrospective analysis of performance test data for 383 officers (362 males, 21 females) was conducted. The tests included: sit-and-reach to determine hamstring and lower back flexibility; maximal push-up and sit-up repetitions in 60 s to measure muscle endurance; vertical jump (VJ) to assess lower-body power; and 2...
April 18, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28445210/perceived-discrimination-and-longitudinal-change-in-kidney-function-among-urban-adults
#10
May A Beydoun, Angedith Poggi-Burke, Alan B Zonderman, Ola S Rostant, Michele K Evans, Deidra C Crews
OBJECTIVE: Perceived discrimination has been associated with psychosocial distress and adverse health outcomes. We examined associations of perceived discrimination measures with changes in kidney function in a prospective cohort study, the Healthy Aging in Neighborhoods of Diversity Across the LifeSpan. METHODS: Our study included 1,620 participants with preserved baseline kidney function (estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73m) (662 Whites and 958 African-Americans (AA), aged 30-64 years)...
April 26, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28445203/considerations-for-refractive-surgery-in-the-glaucoma-patient
#11
Meleha Ahmad, Isaac Chocron, Anurag Shrivastava
PURPOSE OF REVIEW: Given the popularity of keratorefractive surgery, and an aging populous of patients who have undergone these procedures, there is an increasing need for updated management protocols. This is particularly relevant for patients with chronic progressive diseases such as glaucoma, due to the variety of related diagnostic and management challenges inherent to these diseases. Here, we will review the current literature to provide an update on the management of patients with glaucoma who are undergoing, or have had laser ablative refractive surgery...
April 25, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28445077/effect-of-epiretinal-membranes-on-antivascular-endothelial-growth-factor-treatment-for-neovascular-age-related-macular-degeneration
#12
Han Joo Cho, Jae Min Kim, Hyoung Seok Kim, Dong Won Lee, Chul Gu Kim, Jong Woo Kim
PURPOSE: To evaluate the effect of epiretinal membranes (ERMs), detected with spectral-domain optical coherence tomography (SD-OCT), on the outcome of antivascular endothelial growth factor (VEGF) treatment for neovascular age-related macular degeneration (nAMD). METHODS: A total of 434 eyes with treatment-naive nAMD were retrospectively included and analyzed. All patients were administered an initial series of 3 monthly loading injections of ranibizumab or aflibercept, followed by further injections as required...
April 26, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28444926/which-blood-pressure-measurement-systolic-or-diastolic-better-predicts-future-hypertension-in-normotensive-young-adults
#13
Hiroshi Kanegae, Takamitsu Oikawa, Yukie Okawara, Satoshi Hoshide, Kazuomi Kario
The impact of age-related differences in blood pressure (BP) components on new-onset hypertension is not known. A follow-up examination of 93 303 normotensive individuals (mean age 41.1 years) who underwent a health checkup in 2005 was conducted every year for 8 years. The primary end point was new-onset hypertension (systolic BP [SBP]/diastolic BP [DBP] ≥140/90 mm Hg and/or the initiation of antihypertensive medications with self-reported hypertension). During the mean 4.9 years of follow-up, 14 590 subjects developed hypertension...
April 26, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28444834/direct-and-indirect-effects-of-attention-and-visual-function-on-gait-impairment-in-parkinson-s-disease-influence-of-task-and-turning
#14
Samuel Stuart, Brook Galna, Louise S Delicato, Sue Lord, Lynn Rochester
Gait impairment is a core feature of Parkinson's disease (PD) which has been linked to cognitive and visual deficits, but interactions between these features are poorly understood. Monitoring saccades allows investigation of real-time cognitive and visual processes and their impact on gait when walking. This study explored; 1) saccade frequency when walking under different attentional manipulations of turning and dual-task; and 2) direct and indirect relationships between saccades, gait impairment, vision and attention...
April 26, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28444697/population-pharmacokinetics-of-dexmedetomidine-in-infants
#15
Rachel G Greenberg, Huali Wu, Matthew Laughon, Edmund Capparelli, Stevie Rowe, Kanecia O Zimmerman, P Brian Smith, Michael Cohen-Wolkowiez
Despite limited pharmacokinetic (PK) data, dexmedetomidine is increasingly being used off-label for sedation in infants. We aimed to characterize the developmental PK changes of dexmedetomidine during infancy. In this open-label, single-center PK study of dexmedetomidine in infants receiving dexmedetomidine per clinical care, ≤10 blood samples per infant were collected. A set of structural PK models and residual error models were explored using nonlinear mixed-effects modeling in NONMEM. Covariates including postmenstrual age (PMA), serum creatinine, and recent history of cardiac surgery requiring cardiopulmonary bypass were investigated for their influence on PK parameters...
April 25, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28444618/rna-dna-co-analysis-on-aged-bloodstains-from-adhesive-tapes-used-for-gunshot-residue-collection-from-hands
#16
Melanie Grabmüller, Christian Schyma, Burkhard Madea, Tim Eichhorst, Cornelius Courts
In cases of firearm related fatalities a systematic investigation at the scene of death is indispensable to differentiate between self-inflicted and homicidal gunshot injuries. A common method to preserve gunshot residues (GSR) is their collection using adhesive tapes. However, the biological material gathered at the same time by the tapes would be of special interest if backspatter, ejected from the entrance wound against the direction of fire, could be detected. In the present study we examined the success rate of co-analysis of RNA and DNA recovered from biological traces sampled with adhesive tapes...
April 25, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28444552/income-and-health-related-quality-of-life-among-prostate-cancer-patients-over-a-one-year-period-after-radical-prostatectomy-a-linear-mixed-model-analysis
#17
Jens Klein, Daniel Lüdecke, Kerstin Hofreuter-Gätgens, Margit Fisch, Markus Graefen, Olaf von dem Knesebeck
PURPOSE: To examine income-related disparities in health-related quality of life (HRQOL) over a one-year period after surgery (radical prostatectomy) and its contributory factors in a longitudinal perspective. Evidence of associations between income and HRQOL among patients with prostate cancer (PCa) is sparse and their explanations still remain unclear. METHODS: 246 males of two German hospitals filled out a questionnaire at the time of acute treatment, 6 and 12 months later...
April 25, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28444546/continuous-magnesium-infusions-in-the-management-of-systemic-anti-cancer-therapy-related-hypomagnesaemia
#18
Hector Mateo-Carrasco, Oluwakemi Kostrzynski, Onyinye Ndefo, Simon Stapley, Elaine Davies, Roshan Agarwal
Background Hypomagnesaemia is a relatively-common side effect of some systemic anti-cancer therapies (SACT). Oral and intravenous magnesium (given as injections or short infusions) have problems arising from their poor tolerability, and need for frequent administrations, respectively. Objective Assessing the effectiveness and safety of weekly continuous magnesium infusions (CMI) in the management of SACT-related hypomagnesaemia. Methods CMIs (initiated at 10 mmol/day and up-titrated subject to response) were prescribed to patients with ≥3 magnesium readings <0...
April 25, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28444539/association-of-the-oas3-rs1859330-g-a-genetic-polymorphism-with-severity-of-enterovirus-71-infection-in-chinese-han-children
#19
Yuxia Tan, Tingting Yang, Peipei Liu, Liping Chen, Qingwu Tian, Ya Guo, Hongfang He, Yedan Liu, Zongbo Chen
The 2'5'-oligoadenylate synthetase (OAS) is an interferon (IFN)-induced protein that plays an important role in the antiviral action of IFN, with OAS3 being one of the four OAS classes (OAS1, OAS2, OAS3, OASL). The effect of OAS on several infectious viral diseases has been reported; however, a study of the effect of OAS3 on enterovirus 71 (EV71) is lacking. The purpose of this study was to evaluate the association of the OAS3 rs1859330 G/A genetic polymorphism with susceptibility and severity of EV71 infection...
April 25, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28444481/peer-victimization-and-suicidal-thoughts-and-behaviors-in-depressed-adolescents
#20
Jeremy G Stewart, Linda Valeri, Erika C Esposito, Randy P Auerbach
Suicide is a leading cause of death among youth worldwide, and depressed adolescents are at a significantly elevated risk to report suicidal ideation, planning, and attempts. Peer victimization is a robust predictor of adolescent suicidal thoughts and behaviors (STBs), but little research has focused on why bullying leads to suicidal thoughts and behaviors. To address this empirical gap, we recruited 340 (246 female) depressed adolescents ages 13-19 (M = 15.59, SD = 1.41) within 48 h of admission for acute psychiatric treatment...
April 25, 2017: Journal of Abnormal Child Psychology
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