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Duodenal ulcer

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https://www.readbyqxmd.com/read/28210269/low-prevalence-of-clinically-significant-endoscopic-findings-in-outpatients-with-dyspepsia
#1
Khaled Abdeljawad, Antonios Wehbeh, Emad Qayed
Background. The value of endoscopy in dyspeptic patients is questionable. Aims. To examine the prevalence of significant endoscopic findings (SEFs) and the utility of alarm features and age in predicting SEFs in outpatients with dyspepsia. Methods. A retrospective analysis of outpatient adults who had endoscopy for dyspepsia. Demographic variables, alarm features, and endoscopic findings were recorded. We defined SEFs as peptic ulcer disease, erosive esophagitis, malignancy, stricture, or findings requiring specific therapy...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28207574/laparoscopic-and-open-surgical-treatment-in-gastroduodenal-perforations-our-experience
#2
Rita Laforgia, Giovanni Balducci, Giuseppe Carbotta, Antonio Prestera, Maria Grazia Sederino, Giulia Casamassima, Marina Minafra, Pierluca Sallustio, Nicola Palasciano
INTRODUCTION: Peptic ulcer perforation (PPU) is a common surgical emergency and the mortality rate ranges 10% to 40%, especially in elderly patients. Laparoscopic repair achieved encouraging results. MATERIALS AND METHODS: We enrolled patients performing surgical repair for PPU from January 2007 to December 2015 in our surgical unit. The aim of this retrospective observational study was to compare the results of PPU laparoscopic repair with open technique. The following characteristics of patients were evaluated: age, sex and American Society of Anesthesiologists classification...
February 15, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28207313/continuous-radiotelemetric-monitoring-of-intragastric-ph-in-a-dog-with-peptic-ulceration
#3
Michael B Lane, Jeanne C Larson, Jennifer E Stokes, M Katherine Tolbert
CASE DESCRIPTION A 6-year-old castrated male Boxer was evaluated for a 5-week history of frequent vomiting, melena, and signs of abdominal pain following accidental ingestion of 5 to ten 15-mg meloxicam tablets (approx ingested dose, 3.1 to 6.2 mg/kg [1.4 to 2.8 mg/lb]). CLINICAL FINDINGS Clinical signs persisted despite 3 weeks of treatment with sucralfate (41.8 mg/kg [19 mg/lb], PO, q 8 h) and omeprazole (0.8 mg/kg [0.36 mg/lb], PO, q 24 h). Results of a CBC and serum biochemical analysis were unremarkable...
March 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28202872/duodenal-ulcer-iga-vasculitis
#4
Kazuaki Fukushima, Naoki Yanagisawa
No abstract text is available yet for this article.
2017: Internal Medicine
https://www.readbyqxmd.com/read/28189119/roux-en-y-duodenojejunostomy-for-surgical-management-of-isolated-duodenal-obstruction-due-to-chronic-pancreatitis
#5
Himanshu Sharma, Sanjay Marwah, Priyanka Singla, Amit Garg, Bittu Bhukkal
INTRODUCTION: Duodenal obstruction in case of chronic pancreatitis is a very rare occurrence and usually presents with gastric outlet obstruction. These cases sometimes require surgical intervention when conservative treatment fails. Gastrojejunostomy and vagotomy has conventionally been performed for management of these cases. PRESENTATION OF CASE: In this report, we present two cases of isolated duodenal obstruction due to chronic pancreatitis that were managed with Roux-en-Y duodenojejunostomy...
January 28, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28176219/large-buffering-effect-of-the-duodenal-bulb-in-duodenal-switch-a-wireless-ph-metric-study
#6
Z Bekhali, J Hedberg, H Hedenström, M Sundbom
INTRODUCTION: Bariatric procedures result in massive weight loss, however, not without side effects. Gastric acid is known to cause marginal ulcers, situated in the small bowel just distal to the upper anastomosis. We have used the wireless BRAVO™ system to study the buffering effect of the duodenal bulb in duodenal switch (DS), a procedure in which the gastric sleeve produces a substantial amount of acid. METHODS: We placed a pre- and a postpyloric pH capsule in 15 DS-patients (seven men, 44 years, BMI 33) under endoscopic guidance and verified the correct location by fluoroscopy...
February 7, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28166080/stress-induced-gastric-ulcers-presenting-as-massive-rectal-bleeding-in-a-newborn
#7
A Joshi, P S Shrestha, S Dangol, N C Shrestha, P Poudyal, A Shrestha A
Severe gastrointestinal bleeding in newborn period is a serious but uncommon phenomenon that has a broad differential diagnosis. Primary duodenal ulcers are rare in children but stress induced ulceration in stomach occurs more often in neonatal period due to birth asphyxia, prolonged labour, cesarean deliveries, instrumentations, respiratory distress syndrome and sepsis. These present as acute onset of gastrointestinal bleeding commonly as altered gastric aspirate, hematemesis or malena. We report a case of a neonate with stress induced gastric bleeding following birth asphyxia who presented with massive gastrointestinal bleed manifesting as hematemesis and massive rectal bleeding...
April 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/28160741/report-of-two-cases-of-large-cell-neuroendocrine-carcinoma-of-duodenal-ampulla-with-contrasting-outcomes-following-pancreaticoduodenectomy-according-to-the-use-of-adjuvant-chemotherapy
#8
Naoya Imamura, Atsushi Nanashima, Masahide Hiyoshi, Yoshiro Fujii
INTRODUCTION: Large-cell neuroendocrine carcinoma (LCNEC) in the duodenal ampulla of Vater is a rare malignant tumor, with frequent postoperative recurrence and poor prognosis even following complete resection. Effective adjuvant chemotherapy is expected to offer longer survival. PRESENTATION OF CASE: We present two patients with LCNEC accompanied by components of tubular adenocarcinoma/adenoma in the duodenal ampulla of Vater who underwent pancreaticoduodenectomy (PD), resulting in longer survival of 1 patient...
January 17, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28150170/-duodenal-ulcers-gastric-ulcers-and-helicobacter-pylori
#9
Peter Dovjak
The mortality in elderly patients over the age of 80 years with peptic ulcers in the case of complications, such as bleeding and perforation is higher than in the general population. Duodenal ulcers are associated with Helicobacter pylori infections in 90% of cases and in 70% of gastric ulcers. The treatment of elderly patients is often difficult due to multimorbidity and polypharmacy and necessitates a geriatric approach. Ulcers are often caused by medication with nonsteroidal anti-inflammatory drugs (NSAIDs) and acetylsalicylic acid...
February 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28139747/roxatidine-attenuates-mast-cell-mediated-allergic-inflammation-via-inhibition-of-nf-%C3%AE%C2%BAb-and-p38-mapk-activation
#10
Minho Lee, Na Young Lee, Kyung-Sook Chung, Se-Yun Cheon, Kyung-Tae Lee, Hyo-Jin An
Roxatidine is an active metabolite of roxatidine acetate hydrochloride which is a histamine H2-receptor antagonist that is used to treat gastric and duodenal ulcers. In this study, we investigated the anti-allergic inflammatory effects and the underlying molecular mechanism of roxatidine in phorbol 12-myristate 13-acetate and calcium ionophore (PMACI)-stimulated human mast cells-1 (HMC-1), compound 48/80-induced anaphylactic animal model and chemical allergen-induced contact hypersensitivity (CHS) models. Roxatidine suppressed the mRNA and protein expression of inflammatory cytokines such as TNF-α, IL-6, and IL-1β in PMACI-stimulated HMC-1 and compound 48/80-induced anaphylactic mice...
January 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28139495/efficacy-of-proton-pump-inhibitors-for-patients-with-duodenal-ulcers-a-pairwise-and-network-meta-analysis-of-randomized-controlled-trials
#11
REVIEW
Zhan-Hong Hu, Ai-Ming Shi, Duan-Min Hu, Jun-Jie Bao
BACKGROUND/AIM: To compare the efficacy and tolerance of different proton pump inhibitors (PPIs) in different doses for patients with duodenal ulcers. MATERIALS AND METHODS: An electronic database was searched to collect all randomized clinical trials (RCTs), and a pairwise and network meta-analysis were performed. RESULTS: A total of 24 RCTs involving 6188 patients were included. The network meta-analysis showed that there were no significant differences for the 4-week healing rate of duodenal ulcer treated with different PPI regimens except pantoprazle 40 mg/d versus lansoprazole 15 mg/d [Relative risk (RR) = 3...
January 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28138756/treatment-with-sofosbuvir-and-ledipasvir-without-ribavirin-for-12%C3%A2-weeks-is-highly-effective-for-recurrent-hepatitis-c-virus-genotype-1b-infection-after-living-donor-liver-transplantation-a-japanese-multicenter-experience
#12
Yoshihide Ueda, Toru Ikegami, Nobuhisa Akamatsu, Akihiko Soyama, Masahiro Shinoda, Ryoichi Goto, Hideaki Okajima, Tomoharu Yoshizumi, Akinobu Taketomi, Yuko Kitagawa, Susumu Eguchi, Norihiro Kokudo, Shinji Uemoto, Yoshihiko Maehara
BACKGROUND: The optimal therapy for recurrent hepatitis C virus (HCV) infection after liver transplantation has not yet been established. This study aimed to clarify the efficacy and safety of interferon-free therapy with sofosbuvir and ledipasvir without ribavirin for 12 weeks in Japanese patients with HCV genotype 1b infection after living donor liver transplantation. METHODS: A cohort study of living donor liver transplant recipients with recurrent HCV genotype 1b infection treated with sofosbuvir (400 mg/day) and ledipasvir (90 mg/day) was performed at six liver transplant centers in Japan...
January 30, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28134673/tolerability-and-long-term-outcomes-of-dose-painted-neoadjuvant-chemoradiation-to-regions-of-vessel-involvement-in-borderline-or-locally-advanced-pancreatic-cancer
#13
Jennifer Y Wo, Andrzej Niemierko, David P Ryan, Lawrence S Blaszkowsky, Jeffrey W Clark, Eunice L Kwak, Keith D Lillemoe, Lorraine N Drapek, Andrew X Zhu, Jill N Allen, Jason E Faris, Janet E Murphy, Ryan Nipp, Carlos Fernandez-Del Castillo, Cristina R Ferrone, Theodore S Hong
PURPOSE: We reviewed our experience involving patients with borderline resectable or locally advanced pancreatic cancer, treated with the dose-painted (DP) boost technique to regions of vessel involvement which preclude upfront surgical resection. We evaluated patient outcomes with respect to tolerability and treatment outcomes. MATERIALS AND METHODS: We retrospectively reviewed 99 patients with borderline resectable (n=25) or locally advanced pancreatic cancer (n=74) treated with DP-neoadjuvant chemoradiation from 2010 to 2015...
January 27, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28134570/fatty-acid-composition-and-mechanisms-of-the-protective-effects-of-myrtle-berry-seed-aqueous-extract-in-alcohol-induced-peptic-ulcer-in-rat
#14
Mohamed-Amine Jabri, Kais Rtibi, Haifa Tounsi, Karim Hosni, Lamjed Marzouki, Mohsen Sakly, Hichem Sebai
This study aimed to investigate the antiulcer and antioxidant activities of myrtle berry seed aqueous extract (MBSAE) in a peptic ulcer model induced by ethanol in male Wistar rats. MBSAE is rich in total polyphenols, total flavonoids, and unsaturated fatty acids, particularly linoleic (18:2) and oleic (18:1) acids. MBSAE also exhibited in vitro antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) (IC50 = 172.1 μg/mL) and superoxide anion (IC50 = 200.24 μg/mL) scavenging activities. In vivo, MBSAE provided dose-dependent protection against ethanol-induced gastric and duodenal macroscopic and histological alterations...
November 10, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28131855/helicobacter-pylori-treatment-new-perspectives-using-current-experience
#15
REVIEW
Amin Talebi Bezmin Abadi
Infection with Helicobacter pylori plays an essential role in the development of duodenal and gastric ulcers as well as in the pathobiology of gastric adenocarcinoma. Thus, successful elimination of the bacterium can reduce the risk of development of these diseases. Currently, most guidelines recommend standard triple therapy (amoxicillin+clarithromycin+proton pump inhibitor), although its efficacy is rapidly falling. Notably, traditional first-line therapy fails in almost 32% of H. pylori-carrying cases, suggesting the importance of choosing the best formulation for first-line therapy...
January 25, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28130285/migrating-coil
#16
Kai Rou Tey, Avin Aggarwal, Bhaskar Banerjee
We describe a rare case of a 60-year-old man with known history of peptic ulcer disease who presented with melena and epigastric pain secondary to coil migration into duodenal mucosa 4 years after the initial therapeutic embolisation of the gastroduodenal artery. Upper endoscopy revealed oozing duodenal ulcer at the same site of the previously located duodenal ulcer 4 years ago and metal coil impacted at the duodenal mucosa. It is unclear if the coil migration is the effect or the cause of the bleeding duodenal ulcer...
January 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28125638/vaca-and-caga-status-as-biomarker-of-two-opposite-end-outcomes-of-helicobacter-pylori-infection-gastric-cancer-and-duodenal-ulcer-in-a-moroccan-population
#17
Mounia El Khadir, Samia Alaoui Boukhris, Dafr-Allah Benajah, Karima El Rhazi, Sidi Adil Ibrahimi, Mohamed El Abkari, Taoufiq Harmouch, Chakib Nejjari, Mustapha Mahmoud, Mohamed Benlemlih, Bahia Bennani
Helicobacter pylori (H. pylori) infection induces inflammation of the gastric mucosa, which may progress to precancerous lesions leading to gastric cancer. Pathological determinism is associated to some virulence genes of the bacterium, notably the vacA and cagA genes. The present study aimed to determine the H. pylori genotypes distribution and their association with sex, age and gastric diseases in a Moroccan population. Gastric biopsy was taken from 1079 consenting patients. The specimens were processed by PCR to identify H...
2017: PloS One
https://www.readbyqxmd.com/read/28124306/gastrointestinal-bleeding-in-patients-with-renal-failure-under-hemodialysis-treatment-a-single-center-experience
#18
Özgür Can, Gözde Koç, Sema Berk Ocak, Nursel Akbay, Emel Ahishali, Mustafa Canbakan, Gülizar Manga Şahin, Süheyla Apaydin
PURPOSE: Gastrointestinal bleeding remains the leading cause of morbidity and mortality for patients who need hemodialysis treatment. Our aim was to evaluate patients who needed hemodialysis and presented with bleeding during their hospital stay (uremic bleeding patients). Factors that increased the risk of bleeding and death were evaluated. Additionally, uremic bleeding patients were compared to non-uremic bleeding patients regarding gastrointestinal findings. PATIENTS AND METHODS: Fifty-one uremic bleeding patients were compared to two control groups which included uremic (hemodialysis dependent and non-bleeding) and non-uremic (no renal insufficiency and bleeding) patients...
January 25, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28119948/successful-endoscopic-management-of-non-healing-perforated-duodenal-ulcer-with-polyglycolic-acid-sheet-and-fibrin-glue
#19
Tsuyoshi Mishiro, Kotaro Shibagaki, Kayo Matsuda, Chika Fukuyama, Mayumi Okada, Hironobu Mikami, Daisuke Izumi, Noritsugu Yamashita, Eiko Okimoto, Naoki Fukuda, Masahito Aimi, Nobuhiko Fukuba, Naoki Oshima, Toshihiro Takanashi, Takeshi Matsubara, Norihisa Ishimura, Shunji Ishihara, Yoshikazu Kinoshita
In recent years, treatment techniques in which polyglycolic acid sheets are applied to various situations with fibrin glue have exhibited great clinical potential, and previous studies have reported safety and efficacy. We describe closure of a non-healing perforated duodenal ulcer with the use of a polyglycolic acid sheet and fibrin glue in an elderly patient who was not a candidate for surgery.
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28119940/a-bleeding-duodenal-gist-masquerading-as-refractory-peptic-ulcer-disease
#20
Jason D Jones, Stephen Oh, Clancy Clark, Rishi Pawa
Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract; however, the occurrence of a GIST in the duodenum is rare. Our case demonstrates the importance of considering GIST in the evaluation of refractory duodenal ulcers, as well as the utilization of endoscopic ultrasound in the evaluation of these lesions.
August 2016: ACG Case Reports Journal
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