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https://www.readbyqxmd.com/read/29151253/a-two-week-fecal-microbiota-transplantation-course-in-pediatric-patients-with-inflammatory-bowel-disease
#1
Katarzyna Karolewska-Bochenek, Pawel Grzesiowski, Aleksandra Banaszkiewicz, Agnieszka Gawronska, Maria Kotowska, Marcin Dziekiewicz, Piotr Albrecht, Andrzej Radzikowski, Izabella Lazowska-Przeorek
Dysbiosis plays a major role in the etiology of inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) is a new promising option for IBD treatment. We aimed to assess the effectiveness of a two-week FMT course in children with IBD. Ten patients, 10-17 years of age with moderate to severe IBD received a course of eight doses of freshly prepared FMT via a naso-duodenal tube or gastroscopy. All of the patients had pancolitis. There were eight cases of ulcerative colitis (UC) and two of Crohn's disease (CD)...
November 19, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29151240/rare-entities-of-histopathological-findings-in-755-sleeve-gastrectomy-cases-a-synopsis-of-preoperative-endoscopy-findings-and-histological-evaluation-of-the-specimen
#2
Erkan Yardimci, Suleyman Bozkurt, Lutfullah Baskoy, Huseyin Kazim Bektasoglu, Melin Ozgun Gecer, Samet Yigman, Huseyin Akbulut, Halil Coskun
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is the most preferred technique in morbidly obese patients for weight loss. There is a controversy about the routine preoperative evaluation of the stomach and the routine microscopic examination of all LSG specimens. Our aim is to analyze the results of both preoperative upper gastrointestinal endoscopy and endoscopic biopsies and also the results of histopathological examination of LSG specimens. MATERIALS AND METHODS: The data of patients who underwent LSG from January 2011 to November 2016 were analyzed retrospectively from a prospectively collected database...
November 18, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29138101/primary-antibiotic-resistance-of-helicobacter-pylori-in-chinese-patients-a-multi-region-prospective-7-year-study
#3
Dong-Sheng Liu, You-Hua Wang, Zhi-Rong Zeng, Zhen-Yu Zhang, Hong Lu, Jian-Ming Xu, Yi-Qi Du, Yan Li, Jiang-Bin Wang, San-Ping Xu, Ye Chen, Chun-Hui Lan, Hong Cheng, Ming-de Jiang, Ling-Xia Zhang, Li-Juan Huo, Shi-Yao Chen, Guo-Xin Zhang, Kai-Chun Wu, Xuan Zhu, You-Xiang Chen, Yin Zhu, Xu Shu, Yong Xie, Nong-Hua Lu
OBJECTIVES: To explore the characteristics of H. pylori resistance in China and the association between antibiotic resistance and several clinical factors. METHODS: H. pylori strains were collected from patients in 13 provinces/cities in China between 2010 and 2016. Demographic data including type of disease, geographic area, age, gender and isolation year were collected to analyse their association with antibiotic resistance. Antibiotic resistance was detected using the Epsilometer test and the Kirby-Bauer disk diffusion method...
November 11, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29119032/cytomegalovirus-associated-duodenal-ulcer-and-duodenitis-in-a-malnourished-pediatric-patient
#4
Rachel Bernard, Ghanim Aljomah, Emily Klepper, Elizabeth McDonough
Cytomegalovirus (CMV) duodenitis is a rare occurrence, especially in pediatric patients. A thirteen-month-old female presented to the Emergency Department for a febrile seizure. She was incidentally admitted for severe malnutrition with an initial workup remarkable for only a slight elevation in her ALT at 48. The patient was found to have an oral aversion requiring nasogastric tube feeds for adequate caloric intake. She continued to fail to gain weight and underwent an EGD that demonstrated a duodenal ulcer...
2017: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/29105542/cervical-necrotizing-fasciitis-an-overlooked-diagnosis-of-a-fatal-disease
#5
Mohamed A Al-Ali, Ashraf F Hefny, Kamal M Idris, Fikri M Abu-Zidan
BACKGROUND: Necrotizing fasciitis of the neck is a rare potentially lethal condition if not early diagnosed and managed. We aimed to study the clinical presentation, radiological and microbiological diagnosis, management, and surgical outcome of patients having cervical necrotizing fasciitis (CNF). MATERIALS AND METHODS: We retrospectively studied patients having a final diagnosis of CNF who were treated at Al Ain Hospital during the period of January 2000 to December 2016...
November 6, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29100443/effects-of-alcohol-consumption-cigarette-smoking-and-betel-quid-chewing-on-upper-digestive-diseases-a-large-cross-sectional-study-and-meta-analysis
#6
Yun-Shiuan Chuang, Meng-Chieh Wu, Fang-Jung Yu, Yao-Kuang Wang, Chien-Yu Lu, Deng-Chyang Wu, Chie-Tong Kuo, Ming-Tsang Wu, I-Chen Wu
Cigarette smoking is a well-known risk factor of upper digestive diseases. Findings on alcohol's effect on these diseases are inconsistent and with the exception of its association with esophageal cancer, little is known about betel quid chewing. This study investigated the association between use of these three substances and upper digestive diseases. We collected data from 9,275 patients receiving upper endoscopies between April 2008 and December 2013. Polynomial regressions were used to analyze the association between risk factors and diseases of the esophagus, stomach and duodenum...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29099778/upper-gastrointestinal-bleeding-in-children-a-tertiary-united-kingdom-children-s-hospital-experience
#7
Omar Nasher, David Devadason, Richard J Stewart
The aim of this study was to review the aetiology, presentation and management of these patients with upper gastrointestinal bleeding (UGIB) at a tertiary children's unit in the United Kingdom. This was a retrospective single-institution study on children (<16 years) who presented with acute UGIB over a period of 5 years using known International Classification of Diseases (ICD) codes. A total of 32 children (17 males, 15 females) were identified with a total median age at presentation of 5.5 years. The majority (24/32) of patients presented as an emergency...
November 3, 2017: Children
https://www.readbyqxmd.com/read/29099093/functional-dyspepsia
#8
REVIEW
Paul Enck, Fernando Azpiroz, Guy Boeckxstaens, Sigrid Elsenbruch, Christine Feinle-Bisset, Gerald Holtmann, Jeffrey M Lackner, Jukka Ronkainen, Michael Schemann, Andreas Stengel, Jan Tack, Stephan Zipfel, Nicholas J Talley
Functional dyspepsia is one of the most prevalent functional gastrointestinal disorders. Functional dyspepsia comprises three subtypes with presumed different pathophysiology and aetiology: postprandial distress syndrome (PDS), epigastric pain syndrome (EPS) and a subtype with overlapping PDS and EPS features. Functional dyspepsia symptoms can be caused by disturbed gastric motility (for example, inadequate fundic accommodation or delayed gastric emptying), gastric sensation (for example, sensations associated with hypersensitivity to gas and bloating) or gastric and duodenal inflammation...
November 3, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29094323/enormous-postoperative-perforation-after-endoscopic-submucosal-dissection-for-duodenal-cancer-successfully-treated-with-filling-and-shielding-by-polyglycolic-acid-sheets-with-fibrin-glue-and-computed-tomography-guided-abscess-puncture
#9
Yoshiko Ohara, Kengo Takimoto, Takashi Toyonaga, Tomohiro Yamaguchi, Hiroya Sakaguchi, Fumiaki Kawara, Shinwa Tanaka, Tsukasa Ishida, Yoshinori Morita, Eiji Umegaki
A female in her 70s underwent esophagogastroduodenoscopy (EGD) for screening, and a 0-IIa lesion measuring approximately 15 mm was detected in the descending portion of the duodenum. Due to the malignant potency of the lesion, endoscopic submucosal dissection (ESD) was performed. Microperforation occurred during ESD. The lesion was removed en bloc and the post-ESD ulcer bed was closed with clips. The next day, the patient had abdominal pain and computed tomography (CT) revealed a small amount of free air in the retroperitoneal space...
November 1, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29072383/-resistance-of-helicobacter-pylori-to-antibiotics-in-israel-past-vs-present
#10
REVIEW
Avi Peretz, Maya Paritsky, Diana Brodsky, Nina Pastukh, Avi On
Helicobacter Pylori (H. Pylori) is a spiral shaped Gram-negative bacterium which is known to cause chronic gastric inflammation (gastritis) that could develop into a gastric or duodenal ulcer. The standard first line therapy for H. Pylori infection is a 7-14 days period of "triple therapy" consisting of proton pump inhibitors (PPI) and the antibiotics clarithromycin and amoxicillin or metronidazole. Recently there has been an increase in H. Pylori resistance to antibiotic treatment. Throughout the years 1999, 2002, 2010, 2013 and 2014 studies have been conducted in Israel that examined H...
October 2017: Harefuah
https://www.readbyqxmd.com/read/29067636/a-novel-finding-of-rapunzel-syndrome
#11
Itaru Iwama, Ryusuke Nambu, Tomoko Hara
Rapunzel syndrome is a rare form of gastric trichobezoar (hair ball) involving extension of a tail of the hair into the small bowel. A 13-year-old girl was admitted with a 4-day history of epigastric pain and nausea which worsened after meals. Abdominal ultrasound showed duodenal wall thickening and lymphadenopathy. Esophagogastroduodenoscopy identified a gastric trichobezoar with a tail extending into the duodenum. In addition, multiple longitudinal duodenal and jejunal ulcers were noted. The ulcers appeared to be a result of direct pressure by the tail itself against the intestinal mucosa...
October 24, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29062455/laparoscopic-pyloroplasty-for-perforated-peptic-ulcer
#12
Edvard Grišin, Saulius Mikalauskas, Tomas Poškus, Valdemaras Jotautas, Kęstutis Strupas
Peptic ulcer is a common disease affecting millions of people every year. Despite improved understanding and treatment of the disease, the number of patients admitted with duodenal peptic ulcer perforation has not decreased. Deaths from peptic ulcer disease overcome other common emergency situations. Laparoscopic repair of the perforated peptic ulcer (PPU) is the gold standard approach for simple perforation. However, in patients with large perforated chronic ulcers laparotomy with pyloroplasty is the standard treatment...
September 2017: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/29049425/comparison-of-internal-medicine-and-general-surgery-residents-assessments-of-risk-of-postsurgical-complications-in-surgically-complex-patients
#13
James M Healy, Kimberly A Davis, Kevin Y Pei
Importance: Anticipating postsurgical complications is a vital physician skill, particularly when counseling surgically complex patients on their risks of intervention. Although internists and surgeons both counsel patients on surgical risks, it is uncertain who is better equipped to accurately anticipate surgical complications. Objective: To examine how internal medicine and general surgery trainees compare in their assessment of risk of surgically complex patients...
October 11, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29049404/low-complexity-microbiota-in-the-duodenum-of-children-with-newly-diagnosed-ulcerative-colitis
#14
Fei Sjöberg, Cecilia Barkman, Intawat Nookaew, Sofia Östman, Ingegerd Adlerberth, Robert Saalman, Agnes E Wold
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by gut dysbiosis. To date, the large bowel microbiota has been in focus. However, the microbiota of the small intestine may also be of importance, as the small bowel is a site for the induction and control of mucosal immune responses, which can be modulated by constituents of the local microbiota. METHODS: Duodenal fluids were collected during diagnostic work-up of treatment-naïve children who were suspected of having IBD...
2017: PloS One
https://www.readbyqxmd.com/read/29038738/a-case-of-infective-endocarditis-and-spinal-epidural-abscess-caused-by-streptococcus-mitis-bacteremia
#15
Victoria S Byrd, Attila S Nemeth
A 57-year-old man presented with abdominal pain, hematemesis, and melena. He reported taking high-dose ibuprofen for back pain and drinking several 24-ounce beers daily. Examination was remarkable for icteric sclera, poor dentition, tachycardia, and crescendo-decrescendo murmur at right upper sternal border, radiating to the carotids. Labs revealed leukocytosis, anemia, thrombocytopenia, and elevated liver function tests and INR. Endoscopy demonstrated antral ulcers, duodenitis, and esophagitis. Blood cultures were obtained and broad-spectrum antibiotics started; cultures later grew Streptococcus mitis, and antibiotic coverage was narrowed...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29038542/store-operated-ca-2-entry-facilitates-the-lipopolysaccharide-induced-cyclooxygenase-2-expression-in-gastric-cancer-cells
#16
Jhen-Hong Wong, Kuo-Hao Ho, Sean Nam, Wen-Li Hsu, Chia-Hsien Lin, Che-Mai Chang, Jaw-Yuan Wang, Wei-Chiao Chang
Helicobacter pylori has been identified as one of the major causes of chronic gastritis, gastric and duodenal ulcers, and gastric cancer. Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria, and H. pylori LPS might play an exclusively important role in activating inflammatory pathways in monocytes and macrophages. To study the role of LPS in the underlying mechanism of inflammatory responses, we established an in vitro model using the human AGS gastric cancer cell line...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29024839/hepatic-artery-aneurysm-causing-gastrointestinal-haemorrhage-case-report-and-literature-review
#17
Saulius Palubinskas, Simon Ladefoged Rasmussen
INTRODUCTION: True hepatic artery aneurysms (HAAs) are rare, and when complicated by gastrointestinal haemorrhage, it becomes an even rarer disease entity. The mortality is high and imaging may fail to provide the diagnosis. We present a case of a true hepatic artery aneurysm complicated by a fistula to the duodenum which was first recognised during surgery. PRESENTATION OF CASE: A 77-year-old man presented with upper gastrointestinal haemorrhage. Upper endoscopy revealed an ulceration in the duodenal bulb, which was refractory to endoscopic treatment...
October 4, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28991840/granulomatous-upper-gastrointestinal-inflammation-in-pediatric-ulcerative-colitis
#18
Karen Queliza, Faith D Ihekweazu, Deborah Schady, Craig Jensen, Richard Kellermayer
OBJECTIVES: Differentiating ulcerative colitis (UC) and Crohn's disease (CD) can be clinically challenging, especially in children. Granulomatous inflammation has traditionally been attributed to CD. Crypt-associated giant cells and granulomas, however, have been observed in colonic biopsies of UC patients. This phenomenon has not been described in the upper gastrointestinal (UGI) tract with UC. METHODS: Seven pediatric UC patients with granulomatous UGI (gUGI) lesions were identified...
October 6, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28988405/a-case-of-adenocarcinoma-developed-in-the-small-intestine-with-chronic-strongyloidiasis
#19
Satoshi Ishikawa, Tamaki Maeda, Kimiaki Hattori, Takahiro Watanabe, Takanori Kuramoto, Saori Ueno, Goro Ueno, Tadahiro Yamada, Akifumi Kanazawa, Masahiro Sakaguchi, Yoshitane Tsukamoto
We experienced a case of intestinal strongyloidiasis complicated by jejunal carcinoma. A Japanese male in his 50s, who has a 7-year medical history of duodenal ulcers, complained of loss of appetite, nausea, vomiting and diarrhea. Computed tomography and gastroduodenal endoscopic examination revealed a stenosis of the duodenum. To remove the stenosis, gastric bypass surgery was performed. The pathological diagnosis of the resected jejunum was strongyloidiasis and well-differentiated adenocarcinoma with subserosal invasion and vascular infiltration...
October 7, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28983161/etiological-and-endoscopic-profile-of-middle-aged-and-elderly-patients-with-upper-gastrointestinal-bleeding-in-a-tertiary-care-hospital-in-north-india-a-retrospective-analysis
#20
Pranav Mahajan, Vijant Singh Chandail
BACKGROUND: Upper gastrointestinal (GI) bleeding is a common medical emergency associated with significant morbidity and mortality. The clinical presentation depends on the amount and location of hemorrhage and the endoscopic profile varies according to different etiology. At present, there are limited epidemiological data on upper GI bleed and associated mortality from India, especially in the middle and elderly age group, which has a higher incidence and mortality from this disease...
July 2017: Journal of Mid-life Health
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