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https://www.readbyqxmd.com/read/28346099/development-of-novel-cell-lines-for-high-throughput-screening-to-detect-estrogen-related-receptor-alpha-modulators
#1
Christina T Teng, Jui-Hua Hsieh, Jinghua Zhao, Ruili Huang, Menghang Xia, Negin Martin, Xiaohua Gao, Darlene Dixon, Scott S Auerbach, Kristine L Witt, B Alex Merrick
Estrogen-related receptor alpha (ERRα), the first orphan nuclear receptor discovered, is crucial for the control of cellular energy metabolism. ERRα and its coactivator, peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), are required for rapid energy production in response to environmental challenges. They have been implicated in the etiology of metabolic disorders such as type 2 diabetes and metabolic syndrome. ERRα also plays a role in the pathogenesis of breast cancer. Identification of compounds that modulate ERRα signaling may elucidate environmental factors associated with these diseases...
January 1, 2017: SLAS Discov
https://www.readbyqxmd.com/read/28345485/the-effect-of-tamoxifen-on-thin-endometrium-in-patients-undergoing-frozen-thawed-embryo-transfer
#2
Hanni Ke, Jingjing Jiang, Mingdi Xia, Rong Tang, Yingying Qin, Zi-Jiang Chen
Tamoxifen has played a vital role in endocrine therapy for the treatment of estrogen receptor-positive breast cancer. We examined the effect of tamoxifen in patients with a thin endometrium in frozen-thawed embryo transfer (FET) cycles and compared the improvement in endometrial thickness (EMT) and pregnancy outcomes stratified by different etiologies of thin endometrium. A total of 226 women were recruited for a new tamoxifen protocol; all had an EMT of less than 7.5 mm in previous cycles, including natural cycle (NC), hormone replacement treatment (HRT), and ovulation induction (OI) cycles...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28344054/the-role-of-cardiac-energy-metabolism-in-cardiac-hypertrophy-and-failure
#3
REVIEW
Tomi Tuomainen, Pasi Tavi
In mammalian heart, incessant production of cellular energy is vital for maintaining continuous mechanical pumping function providing the body for oxygen and nutrients. To ensure this essential function, cardiac muscle adapt to increased energy demand or compromised energy supply by reprogramming the network of genes whose products are necessary to match the production of energy to consumption. Failure in this regulation leads to severe cardiac dysfunction and has been associated with cardiac pathogenesis including cardiac hypertrophy, failure and diabetes...
March 24, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28341248/abnormal-lipid-lipoprotein-metabolism-and-high-plasma-testosterone-levels-in-male-but-not-female-aromatase-knockout-mice
#4
Akiko Amano, Yoshitaka Kondo, Yoshihiro Noda, Mitsuhiro Ohta, Noriaki Kawanishi, Shuichi Machida, Kazuteru Mitsuhashi, Takafumi Senmaru, Michiaki Fukui, Osamu Takaoka, Taisuke Mori, Jo Kitawaki, Masafumi Ono, Toshiji Saibara, Hiroshi Obayashi, Akihito Ishigami
Sex steroid hormones, such as estrogen and testosterone, are believed to play important roles in lipid metabolism. To elucidate the effects of estrogen depletion on lipid metabolism in male and female mice, we used aromatase-knockout (ArKO) mice, in which Cyp19 gene disruption prevented estrogen synthesis in vivo. These mice were divided into the following 4 groups: male and female ArKO mice and male and female wild-type (WT) mice. These mice were fed a normal-fat diet (13.6% fat) ad libitum. At 159 days after birth, the mice were tested for liver and plasma lipid content and hepatic hormone receptor- and lipid/lipoprotein metabolism-related gene expression...
March 21, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28336164/expression-of-unusual-immunohistochemical-markers-in-mucinous-breast-carcinoma
#5
Rodrigo de Andrade Natal, Sophie F Derchain, Marina Pavanello, Geisilene R Paiva, Luis O Sarian, José Vassallo
BACKGROUND: Mucinous breast carcinoma is characterized by the production of variable amounts of mucin. Some studies have addressed immunohistochemical characterization of mucinous breast carcinoma using a limited set of antibodies. However, the purpose of the present study was to investigate a larger panel of markers not widely used in daily practice and to determine their pathological implications. METHODS: Forty patients diagnosed with mucinous breast carcinoma were enrolled...
March 20, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28334178/inter-regional-variations-in-gene-expression-and-age-related-cortical-thinning-in-the-adolescent-brain
#6
Angelita Pui-Yee Wong, Leon French, Gabriel Leonard, Michel Perron, G Bruce Pike, Louis Richer, Suzanne Veillette, Zdenka Pausova, Tomáš Paus
Age-related decreases in cortical thickness observed during adolescence may be related to fluctuations in sex and stress hormones. We examine this possibility by relating inter-regional variations in age-related cortical thinning (data from the Saguenay Youth Study) to inter-regional variations in expression levels of relevant genes (data from the Allen Human Brain Atlas); we focus on genes coding for glucocorticoid receptor (NR3C1), androgen receptor (AR), progesterone receptor (PGR), and estrogen receptors (ESR1 and ESR2)...
February 25, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28333235/ovarian-hormones-and-obesity
#7
Brigitte Leeners, Nori Geary, Philippe N Tobler, Lori Asarian
BACKGROUND: Obesity is caused by an imbalance between energy intake, i.e. eating and energy expenditure (EE). Severe obesity is more prevalent in women than men worldwide, and obesity pathophysiology and the resultant obesity-related disease risks differ in women and men. The underlying mechanisms are largely unknown. Pre-clinical and clinical research indicate that ovarian hormones may play a major role. OBJECTIVE AND RATIONALE: We systematically reviewed the clinical and pre-clinical literature on the effects of ovarian hormones on the physiology of adipose tissue (AT) and the regulation of AT mass by energy intake and EE...
March 2, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28332606/lumican-effectively-regulates-the-estrogen-receptors-associated-functional-properties-of-breast-cancer-cells-expression-of-matrix-effectors-and-epithelial-to-mesenchymal-transition
#8
Konstantina Karamanou, Marco Franchi, Zoi Piperigkou, Corinne Perreau, Francois-Xavier Maquart, Demitrios H Vynios, Stéphane Brézillon
Lumican is a small leucine-rich proteoglycan that has been shown to contribute in several physiological processes, but also to exert anticancer activity. On the other hand, it has been recently shown that knockdown of the estrogen receptor α (ERα) in low invasive MCF-7 (ERα+) breast cancer cells and the suppression of ERβ in highly aggressive MDA-MB-231 (ERβ+) cells significantly alter the functional properties of breast cancer cells and the gene expression profile of matrix macromolecules related to cancer progression and cell morphology...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28331366/the-effects-of-turmeric-curcumin-on-tumor-suppressor-protein-p53-and-estrogen-receptor-er%C3%AE-in-breast-cancer-cells
#9
Kelly Hallman, Katie Aleck, Brigitte Dwyer, Victoria Lloyd, Meghan Quigley, Nada Sitto, Amy E Siebert, Sumi Dinda
Curcumin (CUR) is a compound that has antibacterial, antiviral, anti-inflammatory, and anticancer properties. In this study, we have analyzed the effects of CUR on the expression of ERα and p53 in the presence of hormones and anti-hormones in breast cancer cells. Cells were cultured in a medium containing charcoal-stripped fetal bovine serum to deplete any endogenous steroids and treated with CUR at varying concentrations or in combination with hormones and anti-hormones. Protein analysis revealed a relative decrease in the levels of p53 and ERα upon treatment with 5-60 µM CUR...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28329789/mediterranean-diet-supplemented-with-coenzyme-q10-modulates-the-postprandial-metabolism-of-advanced-glycation-end-products-in-elderly-men-and-women
#10
Javier Lopez-Moreno, Gracia M Quintana-Navarro, Javier Delgado-Lista, Antonio Garcia-Rios, Juan F Alcala-Diaz, Francisco Gomez-Delgado, Antonio Camargo, Pablo Perez-Martinez, Francisco J Tinahones, Gary E Striker, Francisco Perez-Jimenez, Jose M Villalba, Jose Lopez-Miranda, Elena M Yubero-Serrano
Advanced glycation end products (AGEs) and oxidative stress are elevated with aging and dysmetabolic conditions. Because a Mediterranean (Med) diet reduces oxidative stress, serum AGEs levels, and gene expression related to AGEs metabolism in healthy elderly people, we studied whether supplementation with coenzyme Q10 (CoQ) was of further benefit. Twenty participants aged ≥ 65 (10 men and 10 women) were randomly assigned to each of three isocaloric diets for successive periods of 4 weeks in a crossover design: Med diet, Med + CoQ, and a Western high-saturated-fat diet (SFA diet)...
October 21, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28328298/the-synthetic-progestin-gestodene-affects-functional-biomarkers-in-neonatal-rat-osteoblasts-through-an-estrogen-receptor-related-mechanism-of-action
#11
Juana Enríquez, Gustavo García, Bertha Herrero, Fernando Larrea
BACKGROUND: Clinical studies have shown that gestodene (GDN), a potent third-generation synthetic progestin, affects bone resorption. However, its mode of action in bone cells is not fully understood. The aim of this study was to establish whether GDN affects bone directly or through its bioconversion to other metabolites with different biological activities. METHODS: In this study, we investigated the effects of GDN and its A-ring reduced metabolites on proliferation, differentiation, and mineralization of calvarial osteoblasts isolated from neonatal rat and their capacity to displace [(3)H]-E2 at ER binding sites...
March 22, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28328210/reevaluating-the-significance-of-estrone-as-an-environmental-estrogen
#12
Gerald T Ankley, David Feifarek, Brett Blackwell, Jenna E Cavallin, Kathleen M Jensen, Michael D Kahl, Shane Poole, Eric Randolph, Travis Saari, Daniel L Villeneuve
Studies worldwide have demonstrated the occurrence of feminized male fish at sites impacted by human and animal wastes. A variety of chemicals could contribute to this phenomenon, but those receiving the greatest attention in terms of research and monitoring have been 17β-estradiol (β-E2) and 17α-ethinylestradiol, due both to their prevalence in the environment and strong estrogenic potency. A third steroid, estrone (E1), also can occur at high concentrations in surface waters, but generally has been of lesser concern due to its relatively lower affinity for vertebrate estrogen receptors...
March 22, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28326439/a-distinct-functional-distribution-of-%C3%AE-and-%C3%AE-motoneurons-in-the-rat-trigeminal-motor-nucleus
#13
Yukako Morita-Isogai, Hajime Sato, Mitsuru Saito, Eriko Kuramoto, Dong Xu Yin, Takeshi Kaneko, Takashi Yamashiro, Kenji Takada, Seog Bae Oh, Hiroki Toyoda, Youngnam Kang
Gamma-motoneurons (γMNs) play a crucial role in regulating isometric muscle contraction. The slow jaw-closing during mastication is one of the most functional isometric contractions, which is developed by the rank-order recruitment of alpha-motoneurons (αMNs) in a manner that reflects the size distribution of αMNs. In a mouse spinal motor nucleus, there are two populations of small and large MNs; the former was identified as a population of γMNs based on the positive expression of the transcription factor estrogen-related receptor 3 (Err3) and negative expression of the neuronal DNA-binding protein NeuN, and the latter as that of αMNs based on the opposite pattern of immunoreactivity...
March 22, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28324269/metformin-sensitizes-triple-negative-breast-cancer-to-proapoptotic-trail-receptor-agonists-by-suppressing-xiap-expression
#14
Elena Strekalova, Dmitry Malin, Harisha Rajanala, Vincent L Cryns
PURPOSE: Despite robust antitumor activity in diverse preclinical models, TNF-related apoptosis-inducing ligand (TRAIL) receptor agonists have not demonstrated efficacy in clinical trials, underscoring the need to identify agents that enhance their activity. We postulated that the metabolic stress induced by the diabetes drug metformin would sensitize breast cancer cells to TRAIL receptor agonists. METHODS: Human triple (estrogen receptor, progesterone receptor, and HER2)-negative breast cancer (TNBC) cell lines were treated with TRAIL receptor agonists (monoclonal antibodies or TRAIL peptide), metformin, or the combination...
March 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28324268/a-phase-ii-study-of-combined-ridaforolimus-and-dalotuzumab-compared-with-exemestane-in-patients-with-estrogen-receptor-positive-breast-cancer
#15
José Baselga, Serafin M Morales, Ahmad Awada, Joanne L Blum, Antoinette R Tan, Marianne Ewertz, Javier Cortes, Beverly Moy, Kathryn J Ruddy, Tufia Haddad, Eva M Ciruelos, Peter Vuylsteke, Scot Ebbinghaus, Ellie Im, Lamar Eaton, Kumudu Pathiraja, Christine Gause, David Mauro, Mary Beth Jones, Hope S Rugo
PURPOSE: Combining the mTOR inhibitor ridaforolimus and the anti-IGFR antibody dalotuzumab demonstrated antitumor activity, including partial responses, in estrogen receptor (ER)-positive advanced breast cancer, especially in high proliferation tumors (Ki67 > 15%). METHODS: This randomized, multicenter, international, phase II study enrolled postmenopausal women with advanced ER-positive breast cancer previously treated with a nonsteroidal aromatase inhibitor (NCT01234857)...
March 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28318328/estrogen-induces-cxcr4-overexpression-and-cxcr4-cxl12-pathway-activation-in-lung-adenocarcinoma-cells-in-vitro
#16
Vianey Rodriguez-Lara, González-Sánchez Ignacio, Marco A Cerbón Cervantes
PURPOSE: This study was designed to investigate whether estradiol is related to the expression of the chemokine receptor CXCR4 and its activation in lung adenocarcinoma in vitro, since lung adenocarcinomas from premenopausal women have shown high levels of CXCR4, and this expression has been associated with worse prognosis and poor survival. METHODS: The effect of 17-β-estradiol (E2) (0.03 nM-10 nM) on CXCR4 expression was analyzed in lung adenocarcinoma cell lines (SK-LU-1, H1435, H23, A549) by immunofluorescence after 24 and 72-h poststimulation...
March 20, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28315628/association-of-estrogen-receptor-alpha-polymorphisms-with-symptoms-of-autism-among-chinese-han-children
#17
Xuelai Wang, Shuang Liang, Takashi X Fujisawa, Shota Nishitani, Akemi Tomoda, Mingyang Zou, Yang Li, Lijie Wu, Kazuyuki Shinohara
OBJECTIVES: Autism has a significant sex difference. This implies that the sex hormones might have effect on autism. Estrogens play an important role in early nervous system development and sex differentiation through estrogen receptors in brain. Thus, we tested the hypothesis that estrogen receptor alpha (ESR1) gene affects the pathogenesis of autism and related symptoms. METHODS: Genotypes of rs11155819 and rs2234693 were determined in boys with autism and normal boys from Chinese Han population...
November 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28315505/clinicopathological-and-prognostic-value-of-cd24-expression-in-breast-cancer-a-meta-analysis
#18
Gao Liu, Guo-Xing Liu, Yu Fang, Zhen-Yu Cao, Hui-Hui Du, Jie Fu, Ke Qian
BACKGROUND: A number of studies have been conducted to explore the relationship between CD24 expression and the prognosis of breast cancer; however, the results remain inconsistent. Therefore, we performed this meta-analysis to clarify the impact of CD24 expression on clinicopathological features and prognosis of breast cancer. METHODS: A comprehensive literature search for relevant studies was performed, and statistical analysis was conducted using Stata software...
March 3, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28315012/chlorinated-biphenyls-effect-on-estrogen-related-receptor-expression-steroid-secretion-mitochondria-ultrastructure-but-not-on-mitochondrial-membrane-potential-in-leydig-cells
#19
Agnieszka Milon, Malgorzata Opydo-Chanek, Waclaw Tworzydlo, Jerzy Galas, Laura Pardyak, Alicja Kaminska, Anna Ptak, Malgorzata Kotula-Balak
To characterize polychlorinated biphenyls (PCBs) action on Leydig cells, PCBs congeners, low-chlorinated (delor 103; d103) and high-chlorinated ones (delor 106; d106) were selected. The cells were treated according to PCBs dose (d103 or d106 0.2 ng/ml in low doses:, or 2 ng/ml in high doses) and type (d103 + d106 in low doses or 103 + 106 in high doses). After 24 h treatment with PCBs, a distinct increase in estrogen-related receptors (ERRs type α, β and γ) expression was revealed. However, the dose- and type-dependent PCBs effect was mostly exerted on ERRα expression...
March 18, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28314822/topography-and-lateralized-effect-of-acute-aromatase-inhibition-on-auditory-processing-in-a-seasonal-songbird
#20
Geert De Groof, Jacques Balthazart, Charlotte A Cornil, Annemie Van der Lindena
It is increasingly recognized that brain-derived estrogens (neuroestrogens) can regulate brain physiology and behavior much faster than what was previously known from the transcriptional action of estrogens on nuclear receptors. One of the best examples of such neuromodulation by neuroestrogens concerns the acute regulation of sensory coding by the auditory cortex as demonstrated by electrophysiological studies of selected neurons in zebra finches. Yet, the spatial extent of such modulation by neuroestrogens is not known...
March 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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