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https://www.readbyqxmd.com/read/29912219/-quali-strategie-farmacologiche-per-la-doppia-diagnosi-in-alcologia-criticit%C3%A3-e-prospettive-di-intervento
#1
Mario Vitali, Martino Mistretta, Giovanni Alessandrini, Giovanna Coriale, Marina Romeo, Fabio Attilia, Claudia Rotondo, Francesca Sorbo, Fabiola Pisciotta, Maria Luisa Attilia, Mauro Ceccanti
RIASSUNTO. BACKGROUND: Nonostante la rilevanza clinica ed epidemiologica della compresenza di disturbi psichiatrici nella popolazione di pazienti con disturbo da abuso di alcol (DUA), c'è un'importante lacuna nella definizione di metodi e strategie di intervento farmacologiche condivise. Tra le molteplici proposte terapeutiche, non esiste un modello che si sia rivelato valido ed efficace per la gestione farmacologica della doppia diagnosi (DD) in ambito alcologico. Il trattamento non ottimale del disturbo mentale in comorbilità con DUA può portare a un aumento nel rischio di ricadute, con maggiori difficoltà nel mantenere l'astensione da alcol...
May 2018: Rivista di Psichiatria
https://www.readbyqxmd.com/read/29912218/-doppia-diagnosi-complessit%C3%A3-nosografica-e-attualit%C3%A3-di-un-terreno-di-confine-a-lungo-emarginato
#2
Mario Vitali, Francesca Sorbo, Martino Mistretta, Bruna Scalese, Raffaella Porrari, Domenica Galli, Giovanna Coriale, Claudia Rotondo, Simona Solombrino, Maria Luisa Attilia
RIASSUNTO. Il termine "doppia diagnosi" è entrato da anni a far parte del lessico clinico ma la complessità riguardo questi quadri clinici caratterizzati dalla compresenza di un disturbo psichiatrico e di un disturbo da uso di sostanze (nel nostro caso, da alcol) è ancora molta. Nonostante sia dimostrato che nella sola popolazione affetta da abuso di alcol (DUA) il 50,3% dei soggetti abbia avuto un concomitante disturbo psichiatrico nell'arco di vita, a oggi non vi sono linee-guida esaustive per la gestione di questi casi...
May 2018: Rivista di Psichiatria
https://www.readbyqxmd.com/read/29912217/-presa-in-carico-integrata-del-paziente-con-doppia-diagnosi-complessit%C3%A3-e-implicazioni-per-la-pratica-clinica
#3
Mario Vitali, Francesca Sorbo, Martino Mistretta, Giovanna Coriale, Marisa Patrizia Messina, Giovanni Alessandrini, Fabio Attilia, Claudia Rotondo, Simona Gencarelli, Roberta Ledda, Domenica Galli, Mauro Ceccanti
RIASSUNTO. Introduzione. La tutela della salute mentale in Italia, dopo la Legge Basaglia del 1978, è caratterizzata da trattamenti (di norma volontari) erogati da servizi centrati sulla comunità, che hanno allargato gli interventi al contesto di vita dell'individuo, alla sua rete di appartenenza e ai gruppi sociali di riferimento. La doppia diagnosi è definita dall'OMS come la «coesistenza nel medesimo individuo di un disturbo dovuto al consumo di sostanze psicoattive e di un altro disturbo psichiatrico»...
May 2018: Rivista di Psichiatria
https://www.readbyqxmd.com/read/29910103/clinical-diagnosis-scale-for-pain-lumbar-of-facet-origin-systematic-review-of-literature-and-pilot-study
#4
Juan Carlos Gómez Vega, Juan Carlos Acevedo-González
INTRODUCTION: Lumbar pain affects between 60-90% of people. It is a frequent cause of disability in adults. Pain may be generated by different anatomical structures such as the facet joint. However, nowadays pain produced by the facet joint has no clinical diagnosis. Therefore, the purpose of this article is to propose a clinical diagnostic scale for lumbar facet syndrome. MATERIALS AND METHODS: The study was conducted by means of 6 phases as follows, Phase 1, a systematic review of the literature was performed regarding the clinical diagnosis of facet-based lumbar pain based on the PRISMA checklist; Phase 2, a list of signs and symptoms proposed for diagnosis lumbar pain of facet origin was made...
June 14, 2018: Neurocirugía
https://www.readbyqxmd.com/read/29908348/accuracy-of-magnetic-resonance-imaging-techniques-for-parotid-tumors-a-systematic-review-and-meta-analysis
#5
Ying-Ying Liang, Fan Xu, Yuan Guo, Jin Wang
OBJECTIVE: To assess the added benefit of combining different MRI techniques for preoperative diagnosis of parotid tumors when compared to conventional MRI and advanced MRI techniques alone with meta-analysis. METHODS: A comprehensive PubMed electronic database search was performed for original diagnostic studies up to July 2017. The methodologic quality of each study was evaluated by two independent reviewers who used the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool...
June 7, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29906531/association-between-matrix-metalloproteinase-family-gene-polymorphisms-and-risk-of-ischemic-stroke-a-systematic-review-and-meta-analysis-of-29-studies
#6
REVIEW
Shubham Misra, Pumanshi Talwar, Amit Kumar, Pradeep Kumar, Ram Sagar, Deepti Vibha, Awadh K Pandit, Arti Gulati, Suman Kushwaha, Kameshwar Prasad
BACKGROUND: Ischemic stroke (IS) is a complex and devastating vascular disease that has become one of the leading causes of disability and mortality worldwide. Several studies have shown the association between matrix metalloproteinase (MMP) family gene polymorphisms and IS. However, the results have been indecisive. OBJECTIVE: To investigate the association between Matrix Metalloproteinase gene polymorphisms and risk of IS. METHODS: A literature search for eligible candidate gene studies published before, 28 June 2017, was conducted in the PubMed, EMBASE, Cochrane and Google Scholar databases...
June 12, 2018: Gene
https://www.readbyqxmd.com/read/29905962/prevalence-of-hepatitis-b-virus-hepatitis-c-virus-and-human-immunodeficiency-virus-among-blood-donors-of-mekelle-blood-bank-northern-ethiopia-a-three-year-retrospective-study
#7
Berhanu Degefa, Teklehaymanot Gebreeyesus, Zufan Gebremedhin, Getachew Melkamu, Atsebaha Gebrekidan, Haftamu Hailekiros, Ephrem Tsegay, Selam Niguse, Mahmud Abdulkader
Blood transfusion services are a vital and integral part of modern healthcare services. However, the risk of transfusion transmittable infections (TTI) has been a major handicap. Therefore this study was aimed at determining the prevalence of hepatitis B, Hepatitis C and human immunodeficiency virus among blood donors. A retrospective study was conducted to collect data about the blood donors that consecutively donated blood from October 2011 to 2014. A three-year retrospective study was conducted in Mekelle Blood Bank...
June 15, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29904700/data-on-the-effect-of-geological-and-meteorological-parameters-on-indoor-radon-and-thoron-level-case-study-kermanshah-iran
#8
Meghdad Pirsaheb, Farid Najafi, Lida Hemati, Touba Khosravi, Hooshmand Sharafi
The present study was aimed to evaluate the relationship between indoor radon and thoron concentrations, geological and meteorological parameters. The radon and thoron concentrations were determined in three hospitals in Kermanshah, the west part of Iran, using the RTM-1688-2 radon meter. Also, the type and porosity of the underlying soil and the meteorological parameters such as temperature, humidity, atmospheric pressure, rainfall and wind speed were studied and the obtained results analyzed using STATA-Ver...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29903801/protection-of-pregnant-women-at-work-in-switzerland-practices-obstacles-and-resources-a-mixed-methods-study-protocol
#9
Peggy Krief, Alessia Zellweger, Maria-Pia Politis Mercier, Brigitta Danuser, Pascal Wild, Michela Zenoni, Isabelle Probst
INTRODUCTION: Like most industrialised countries, Switzerland has introduced legislation to protect the health of pregnant workers and their unborn children from workplace exposure. This legislation provides for a risk assessment, adaptations to workplaces and, if the danger is not eliminated, preventive leave (prescribed by a gynaecologist). This study's first objective is to analyse the degree to which companies, gynaecologists and midwives implement the law. Its second objective is to understand the obstacles and resources of this implementation, with a focus on how relevant stakeholders perceive protective measures and their involvement with them...
June 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29902980/prevalence-and-associated-factors-of-protein-energy-wasting-among-patients-with-chronic-kidney-disease-at-mulago-hospital-kampala-uganda-a-cross-sectional-study
#10
Lydia Namuyimbwa, Collins Atuheire, Joel Okullo, Robert Kalyesubula
BACKGROUND: Chronic kidney disease (CKD) is global health concern and priority. It is the 12th leading cause of death worldwide. Protein Energy Wasting occurs in 20-25% of patients with chronic kidney disease and can lead to a high morbidity and mortality rate. We determined the prevalence of protein energy wasting and factors associated among patients with chronic kidney disease at Mulago National Referral Hospital, Kampala, Uganda. METHODS: We conducted a cross-sectional study recruiting 182 (89 non-CKD patients and 93 CKD patients) consecutively from the outpatient clinic and wards on New Mulago Hospital complex...
June 14, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29902445/longitudinal-changes-in-pelvic-floor-muscle-strength-among-parous-women
#11
Emily N B Myer, Jennifer L Roem, David A Lovejoy, Melinda G Abernethy, Joan L Blomquist, Victoria L Handa
BACKGROUND: There is limited knowledge of the effects of time on change in pelvic floor muscle strength after childbirth. OBJECTIVE: The objectives of this study were to estimate the change in pelvic floor muscle strength in parous women over time and to identify maternal and obstetric characteristics associated with the rate of change. STUDY DESIGN: This is an IRB approved prospective cohort study of parous women. Participants were recruited 5-10 years after first delivery and followed annually...
June 11, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29901743/predictors-and-temporal-trend-of-flu-vaccination-in-auto-immune-rheumatic-diseases-in-the-uk-a-nationwide-prospective-cohort-study
#12
Georgina Nakafero, Matthew J Grainge, Puja R Myles, Christian D Mallen, Weiya Zhang, Michael Doherty, Jonathan S Nguyen-Van-Tam, Abhishek Abhishek
Objectives: To examine temporal trend in uptake of seasonal influenza vaccine (SIV) in the UK and explore disease and demographic factors associated with vaccination. Methods: From the Clinical Practice Research Datalink, 32 751 people with auto-immune rheumatic diseases prescribed DMARDs between 2006 and 2016 were identified. The proportion vaccinated between 1 September of one year and 31 March of the next year was calculated and stratified by age, other indications for vaccination, auto-immune rheumatic diseases type and number of DMARDs prescribed...
June 12, 2018: Rheumatology
https://www.readbyqxmd.com/read/29901722/genitourinary-surgical-workload-at-deployed-u-s-facilities-in-iraq-and-afghanistan-2002-2016
#13
Caryn A Turner, Jean A Orman, Zsolt T Stockinger, Steven J Hudak
Introduction: Genitourinary surgery constitutes approximately 1.15% of procedures performed for combat injuries. During forward deployment, surgeons usually deploy without urology support. To better understand the training and skills maintenance needs for genitourinary procedures by describing in detail the genitourinary surgical workload during 15 years of combat operations and compare our findings with those from previously published articles. Material and Methods: A retrospective analysis of the Department of Defense Trauma Registry (DoDTR) was performed for all Roles 2 and 3 medical treatment facilities in Iraq and Afghanistan, from January 2002 to May 2016...
June 13, 2018: Military Medicine
https://www.readbyqxmd.com/read/29901582/are-adhd-medications-under-or-over-prescribed-worldwide-protocol-for-a-systematic-review-and-meta-analysis
#14
Carlos Renato Moreira-Maia, Rafael Massuti, Luca Tessari, Fausto Campani, Glaucia Chiyoko Akutagava-Martins, Samuele Cortese, Luis Augusto Rohde
INTRODUCTION: Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder, characterized by age inappropriate and impairing levels of inattention and/or hyperactivity/impulsivity. Pharmacotherapy is an important part of the ADHD multimodal treatment. The extent to which ADHD is pharmacologically over or under treated worldwide is controversial. We aimed to estimate the pooled worldwide rate of ADHD pharmacological treatment in individuals with and without the disorder...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901581/suprapatellar-versus-infrapatellar-intramedullary-nailing-for-tibal-shaft-fractures-a-meta-analysis-of-randomized-controlled-trials
#15
Zhixue Gao, Wei Han, Haigang Jia
BACKGROUND AND OBJECTIVE: The aim of this study was to compare the outcome of using tibial nails inserted by the suprapatellar approach with tibial nails inserted by the infrapatellar approach in a meta-analysis of randomized controlled trials (RCTs). METHODS: The following electronic databases were searched: PubMed (1966 to January 2018), EMBASE (1974 to January 2018), Cochrane Library (January 2018), Web of Science (1990 to January 2018). We also used Google Search Engine to search more potentially eligible studies until January 2018...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29900572/hazard-ratio-estimation-and-inference-in-clinical-trials-with-many-tied-event-times
#16
Devan V Mehrotra, Yiwei Zhang
The medical literature contains numerous examples of randomized clinical trials with time-to-event endpoints in which large numbers of events accrued over relatively short follow-up periods, resulting in many tied event times. A generally common feature across such examples was that the logrank test was used for hypothesis testing and the Cox proportional hazards model was used for hazard ratio estimation. We caution that this common practice is particularly risky in the setting of many tied event times for two reasons...
June 13, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29900131/the-prevalence-of-metabolic-syndrome-in-iran-a-systematic-review-and-meta-analysis
#17
REVIEW
Saeideh Mazloomzadeh, Zahra Rashidi Khazaghi, Nouraddin Mousavinasab
Background: Metabolic syndrome (MS) is a collection of metabolic disorders which leads to early cardiovascular disease and diabetes type II. Regarding the wide range of its prevalence in Iran, this systematic review and meta-analysis determined the overall prevalence of the metabolic syndrome in Iran. Methods: In this systematic review and meta-analysis, the Medline, ISI, IranMedex, and SID were searched using "metabolic syndrome", "syndrome X", "prevalence", and "Iran" keywords from 2002 to 2012...
April 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29899709/clinical-values-of-long-non-coding-rnas-in-bladder-cancer-a-systematic-review
#18
Guoming Su, Qili He, June Wang
Background: Increasing evidence shows that dysregulated expression of long non-coding RNAs (lncRNAs) can serve as diagnostic or prognostic markers in bladder cancer. The aim of this study was to evaluate the clinical values of dysregulated lncRNAs in bladder cancer. Methods: Eligible studies were systematically searched in PubMed, Embase, and Web of Science databases from inception to December 2017. Odds ratios (OR) were calculated to investigate the correlation between lncRNAs and clinicopathological parameters...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29899650/frequency-of-cataract-in-iran-a-meta-analysis-and-systematic-review
#19
Hosien Shahdadi, Mohammad Naim Aminifard, Abbas Balouchi, Hosein Rafiemanesh, Jasem Allahyari
PURPOSE: Cataract is the leading cause of blindness and the second cause of low vision in the world. In the world, Asia has the highest number of blind population. The aim of the present systematic review and meta-analysis was to assess the frequency of clinical cataracts in Iran. MATERIALS AND METHODS: The frequency of clinical cataract was defined based on the international criteria and the measured outcome of the disease. Study selection, data extraction, and quality assessment were performed by two independent reviewers...
January 2018: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29898758/comparison-of-suprapatellar-and-infrapatellar-intramedullary-nailing-for-tibial-shaft-fractures-a-systematic-review-and-meta-analysis
#20
Liqing Yang, Yuefeng Sun, Ge Li
BACKGROUND: Optimal surgical approach for tibial shaft fractures remains controversial. We perform a meta-analysis from randomized controlled trials (RCTs) to compare the clinical efficacy and prognosis between infrapatellar and suprapatellar intramedullary nail in the treatment of tibial shaft fractures. METHODS: PubMed, OVID, Embase, ScienceDirect, and Web of Science were searched up to December 2017 for comparative RCTs involving infrapatellar and suprapatellar intramedullary nail in the treatment of tibial shaft fractures...
June 14, 2018: Journal of Orthopaedic Surgery and Research
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