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https://www.readbyqxmd.com/read/28526006/cardiometabolic-profile-of-obese-children-in-a-sub-saharan-african-setting-a-cross-sectional-study
#1
Eunice Chedjou-Nono, Suzanne Sap, Simeon-Pierre Choukem, Issa Ngosso Tetanye, Daniel Nebongo, Olivier Koki Ndombo
BACKGROUND: Cardiovascular and metabolic consequences of obesity in children, unlike adults, are still not well understood nor have they been subject to extensive research in Africa. We aimed to identify the cardio-metabolic complications associated with childhood obesity at the early phase of the management of obese children in a reference center in Cameroon. METHODS: In this cross-sectional study conducted from November 2013 to September 2014 and based on World Health Organization (WHO) classification of Obesity (BMI > 3SD under 5 years and BMI > 2SD from 5 and above), we included children aged 3 to 17 years who were being followed up for obesity at the pediatric endocrinology unit of the Mother and Child Center of the Chantal BIYA Foundation in Yaounde, Cameroon...
May 19, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28525369/association-between-serum-resistin-concentration-and-hypertension-a-systematic-review-and-meta-analysis
#2
Yuxiang Zhang, Yixing Li, Lin Yu, Lei Zhou
OBJECTIVES: Recent studies have suggested the involvement of adipokines in the pathogenesis of cardiovascular diseases, including hypertension. In this study, we evaluated the significance of serum resistin levels in hypertensive patients using a meta-analysis approach. MATERIALS AND METHODS: Relevant articles were retrieved by searching the following databases: PubMed, Embase, Ovid Medline, ISI Web of Knowledge. The retrieved studies were subjected to a thorough screening procedure to identify case-control studies that contained the required data...
May 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28524030/-preventive-effect-of-vitamin-b-supplementation-on-recurrent-stroke-a-meta-analysis
#3
Guining Dai, Hongzhen Du, Hongmin Wang, Yujia Wei, Ying Xie, Zengning Li
OBJECTIVE: To evaluate whether Vitamin B supplementation could prevent ischemic stroke recurrence. METHODS: Randomized controlled trials (RCTs) observing Vitamin B supplementation in patients with stroke was performed in databases including ScienceDirect, PubMed/Medline, China National Knowledge Infrastructure, Chinese Biomedical Data-Base, Wanfang Database, and VIP Chinese Science and Technology Journal Database to find related studies in English or Chinese published before August 2016...
May 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28521462/microrna-gene-polymorphisms-and-the-risk-of-colorectal-cancer
#4
Guo-Qiang Rong, Xin-Mei Zhang, Bo Chen, Xiao-Dong Yang, Hao-Rong Wu, Wei Gong
The present study was carried out to demonstrate the epidemiological value of microRNA (miRNA) in colorectal cancer (CRC) by investigating the association between miRNA gene polymorphisms and the susceptibility to CRC. Multiple meta-analyses of reported data were conducted, and odds ratio values and 95% confidence intervals were used to assess these associations. Stata 11.0 software was used to analyze the data and the modified Jadad quality score was employed to evaluate the quality of the retrieved studies...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28521005/using-directed-acyclic-graphs-in-epidemiological-research-in-psychosis-an-analysis-of-the-role-of-bullying-in-psychosis
#5
Giusi Moffa, Gennaro Catone, Jack Kuipers, Elizabeth Kuipers, Daniel Freeman, Steven Marwaha, Belinda R Lennox, Matthew R Broome, Paul Bebbington
Modern psychiatric epidemiology researches complex interactions between multiple variables in large datasets. This creates difficulties for causal inference. We argue for the use of probabilistic models represented by directed acyclic graphs (DAGs). These capture the dependence structure of multiple variables and, used appropriately, allow more robust conclusions about the direction of causation. We analyzed British national survey data to assess putative mediators of the association between bullying victimization and persecutory ideation...
May 17, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28515536/estimation-of-the-linear-mixed-integrated-ornstein-uhlenbeck-model
#6
Rachael A Hughes, Michael G Kenward, Jonathan A C Sterne, Kate Tilling
The linear mixed model with an added integrated Ornstein-Uhlenbeck (IOU) process (linear mixed IOU model) allows for serial correlation and estimation of the degree of derivative tracking. It is rarely used, partly due to the lack of available software. We implemented the linear mixed IOU model in Stata and using simulations we assessed the feasibility of fitting the model by restricted maximum likelihood when applied to balanced and unbalanced data. We compared different (1) optimization algorithms, (2) parameterizations of the IOU process, (3) data structures and (4) random-effects structures...
May 24, 2017: Journal of Statistical Computation and Simulation
https://www.readbyqxmd.com/read/28515115/impact-of-antihypertensive-treatment-on-maternal-and-perinatal-outcomes-in-pregnancy-complicated-by-chronic-hypertension-a%C3%A2-systematic-review-and-meta-analysis
#7
REVIEW
Louise M Webster, Frances Conti-Ramsden, Paul T Seed, Andrew J Webb, Catherine Nelson-Piercy, Lucy C Chappell
BACKGROUND: Chronic hypertension complicates around 3% of all pregnancies. There is evidence that treating severe hypertension reduces maternal morbidity. This study aimed to systematically review randomized controlled trials of antihypertensive agents treating chronic hypertension in pregnancy to determine the effect of this intervention. METHODS AND RESULTS: Medline (via OVID), Embase (via OVID) and the Cochrane Trials Register were searched from their earliest entries until November 30, 2016...
May 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28514747/diagnostic-value-of-using-18f-fdg-pet-and-pet-ct-in-immunocompetent-patients-with-primary-central-nervous-system-lymphoma-a-systematic-review-and-meta-analysis
#8
Yaru Zou, Jianjing Tong, Haiyan Leng, Jingwei Jiang, Meng Pan, Zi Chen
BACKGROUND: 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and PET/CT have become two of the most powerful tools for malignant lymphoma exploration, but their diagnostic role in primary central nervous system lymphoma (PCNSL) is still disputed. The purpose of our study is to identify the usefulness of 18F-FDG PET and PET/CT for detecting PCNSL. RESULTS: A total of 129 patients, obtained from eight eligible studies, were included for this systematic review and meta-analysis...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28513635/the-impact-of-dark-chocolate-intake-on-arterial-elasticity-in-individuals-with-hiv-aids-undergoing-art-a-randomized-double-blind-crossover-trial
#9
Andrea Mariana Nunes da Costa Teixeira, Liania Alves Luzia, Suelen Jorge de Souza, Aline de Almeida Petrilli, Patrícia de Moraes Pontilho, Jose Maria Pacheco de Souza, Aluísio Augusto Cotrim Segurado, Priscila Efraim, Camila de Melo Picone, Patrícia Helen de Carvalho Rondo
An increase in the frequency of cardiovascular diseases has been observed in the HIV/AIDS population. Studies involving healthy subjects or subjects with other diseases have shown benefits of chocolate supplementation on endothelial function and vasodilation. We evaluate the impact of chocolate consumption on arterial elasticity in people living with human immunodeficiency virus - PLHIV. A double-blind, crossover trial including 110 PLHIV (19 to 59 years) on antiretroviral therapy - ART for at least 6 months and with a viral load of <500 copies per mL was conducted...
May 17, 2017: Food & Function
https://www.readbyqxmd.com/read/28511657/skilled-delivery-inequality-in-ethiopia-to-what-extent-are-the-poorest-and-uneducated-mothers-benefiting
#10
Brook Tesfaye, Tsedeke Mathewos, Mihiretu Kebede
BACKGROUND: The fifth Millennium Development Goal (MDG) targeted at improving maternal health. In this regard, Ethiopia has shown substantial progresses in the past two decades. Nonetheless, these impressive gains are unevenly distributed among Ethiopian women with different socio-economic characteristics. This study aimed at investigating levels and trends of skilled delivery service, and wealth and education related inequalities from 2000 to 16. METHODS: Longitudinal data analysis was conducted on Ethiopian Demographic and Health Survey (EDHS) data of 2000, 2005, 2011 and 2016...
May 16, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28511456/acute-rubella-virus-infection-among-women-with-spontaneous-abortion-in-mwanza-city-tanzania
#11
Lukombodzo Lulandala, Mariam M Mirambo, Dismas Matovelo, Balthazar Gumodoka, Stephen E Mshana
INTRODUCTION: Acute rubella virus infection in early pregnancy has been associated with poor pregnancy outcome ranging from spontaneous abortion, stillbirth and multiple birth defects known as Congenital Rubella Syndrome (CRS). Despite its importance the prevalence of acute rubella virus infections is not known among women with spontaneous abortion in most centres in developing countries. AIM: The present study was aimed to determine the seroprevalence of acute rubella infection among women with spontaneous abortion in Mwanza city...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28510467/association-between-physicians-adherence-to-a-pharmacotherapy-guideline-and-continuity-of-care-for-patients-with-depression-and-or-anxiety-disorder
#12
Elham Heidari, Saeid Eslami, Farid Abolhassani, Vandad Sharifi, Zhila Taherzadeh, Tahoura Daneshvar
OBJECTIVE: The aim of the paper is to investigate the association between physicians' adherence to a pharmacotherapy guideline and continuity of care for patients with depressive and/or anxiety disorders in a collaborative care program. METHODS: This retrospective observational study was conducted using medical records of subjects suffering from depression and/or anxiety disorder visited by 26 general practitioners (GP) working with  Community Mental Health Center (CMHC), who run a collaborative care program in Tehran, Iran...
May 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28508672/assessing-infant-oriented-care-with-developmental-support-approach-in-iranian-nicus
#13
Mostajab Razavi Nejad, Zahra Eskandary, Mohammad Heidarzadeh, Abolfazl Afjeh, Amir Almasi-Hashiani, Forouzan Akrami
INTRODUCTION: Developmental care program is a comprehensive program to reduce secondary effects of NICU and special care on brain development in premature infants. This study aimed to assess neonatal care situation in Iranian NICUs based on developmental approach to design and provide clinical guidelines for daily care for the care givers and the infant's family. METHODS: This was a cross-sectional study conducted in NICUS in Iran. A total of 23 NICUs of 9 Universities of Medical Sciences were investigated...
May 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28507441/clinicopathological-significance-of-p14-arf-expression-in-lung-cancer-a-meta-analysis
#14
Fang Wang, Heping Li, Jianting Long, Sheng Ye
BACKGROUND: p14(ARF), a tumor suppressor protein, encoded by the p16 tumor suppressor gene, has been reported to be associated with the clinicopathological features of lung cancer. However, the evaluated outcomes were inconsistent and remained inconclusive. In this study, we conducted a meta-analysis to clarify the significance of p14(ARF) expression in lung cancer pathogenesis. MATERIALS AND METHODS: Electronic databases, PubMed, Web of Knowledge, Embase, and CNKI, were retrieved to collect relevant articles with inclusion and exclusion criteria...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28506793/frequency-and-risk-factors-analysis-of-escherichia-coli-o157-h7-in-bali-cattle
#15
I Wayan Suardana, Dyah Ayu Widiasih, Widagdo Sri Nugroho, Michael Haryadi Wibowo, I Nyoman Suyasa
Cattle are known as the main reservoir of zoonotic agents verocytotoxin-producing Escherichia coli. These bacteria are usually isolated from calves with diarrhea and/or mucus and blood. Tolerance of these agents to the environmental conditions will strengthen of their transmission among livestock. A total of 238 cattle fecal samples from four sub-districts in Badung, Bali were used in this study. Epidemiological data observed include cattle age, sex, cattle rearing system, the source of drinking water, weather, altitude, and type of cage floor, the cleanliness of cage floor, the slope of cage floor, and the level of cattle cleanliness...
May 12, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28503277/prevalence-of-diabetes-impaired-fasting-glucose-and-impaired-glucose-tolerance-in-patients-with-thalassemia-major-in-iran-a-meta-analysis-study
#16
REVIEW
Milad Azami, Ali Sharifi, Siros Norozi, Akram Mansouri, Kourosh Sayehmiri
BACKGROUND: This study aimed to investigate the prevalence of diabetes, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) in Iranian patients with thalassemia major. METHODS: The current study has been conducted based on PRISMA guideline. To obtain the documents, Persian and English scientific databases such as Magiran, Iranmedex, SID, Medlib, IranDoc, Scopus, PubMed, ScienceDirect, Cochrane, Web of Science, Springer, Wiley Online Library as well as Google Scholar were searched until December 2015...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28500837/association-between-metformin-and-the-risk-of-gastric-cancer-in-patients-with-type-2-diabetes-mellitus-a-meta-analysis-of-cohort-studies
#17
REVIEW
Xue-Liang Zhou, Wen-Hua Xue, Xian-Fei Ding, Li-Feng Li, Meng-Meng Dou, Wei-Jie Zhang, Zhuan Lv, Zhi-Rui Fan, Jie Zhao, Liu-Xing Wang
OBJECTIVES: The objective of this study was to evaluate the association between metformin therapy and the incidence of gastric cancer (GC) in patients with type 2 diabetes mellitus (T2DM). METHODS: We systemically searched the following databases for studies published between the databases' dates of inception and Nov. 2016: PubMed, Embase, the Cochrane Library, the Web of Science, and the China National Knowledge Infrastructure (CNKI). Hazard ratios (HR)and corresponding 95% confidence intervals (CIs) for the association between metformin therapy and the incidence of GC in patients with T2DM were the outcome measures assessed in this study...
April 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28498841/awareness-and-attitudes-towards-anthrax-and-meat-consumption-practices-among-affected-communities-in-zambia-a-mixed-methods-approach
#18
Doreen Chilolo Sitali, Chisoni Mumba, Eystein Skjerve, Oliver Mweemba, Consolata Kabonesa, Mwinyi Omary Mwinyi, Luke Nyakarahuka, John Bwalya Muma
BACKGROUND: In Zambia, human anthrax cases often occur following cases of animal anthrax. Human behaviour has been implicated in this transmission. The objective of the study was to explore human behavioural patterns that may contribute to outbreaks of anthrax among affected communities. METHODS: A mixed methods study was conducted in four districts of Zambia from November 2015 to February 2016. A cross sectional survey involving 1,127 respondents, six focus group discussions and seven key informant interviews with professional staff were conducted...
May 12, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28498326/a-histopathological-scheme-for-the-quantitative-scoring-of-intervertebral-disc-degeneration-and-the-therapeutic-utility-of-adult-mesenchymal-stem-cells-for-intervertebral-disc-regeneration
#19
Cindy C Shu, Margaret M Smith, Susan M Smith, Andrew J Dart, Christopher B Little, James Melrose
The purpose of this study was to develop a quantitative histopathological scoring scheme to evaluate disc degeneration and regeneration using an ovine annular lesion model of experimental disc degeneration. Toluidine blue and Haematoxylin and Eosin (H&E) staining were used to evaluate cellular morphology: (i) disc structure/lesion morphology; (ii) proteoglycan depletion; (iii) cellular morphology; (iv) blood vessel in-growth; (v) cell influx into lesion; and (vi) cystic degeneration/chondroid metaplasia...
May 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28496443/higher-levels-of-secretory-iga-are-associated-with-low-disease-activity-index-in-patients-with-reactive-arthritis-and-undifferentiated-spondyloarthritis
#20
Fabián Salas-Cuestas, Wilson Bautista-Molano, Juan M Bello-Gualtero, Ivonne Arias, Diana Marcela Castillo, Lorena Chila-Moreno, Rafael Valle-Oñate, Daniel Herrera, Consuelo Romero-Sánchez
INTRODUCTION: Both reactive arthritis (ReA) and undifferentiated spondyloarthritis (uSpA) belong to the group of autoinflammatory diseases called spondyloarthritis (SpA). Hypotheses have been proposed about a relationship between the intestinal mucosa and inflammation of joint tissues. The role of immunoglobulin IgA or secretory immunoglobulin A (SIgA) in the inflammatory and/or clinical activity of patients with SpA remains poorly understood. OBJECTIVE: To evaluate the status of total IgA and SIgA, and the association among the levels of SIgA, IgA, IgA anti-Chlamydia trachomatis, and anti-Shigella spp...
2017: Frontiers in Immunology
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