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https://www.readbyqxmd.com/read/28211499/the-prognostic-value-of-cytotoxic-t-lymphocyte-antigen-4-in-cancers-a-systematic-review-and-meta-analysis
#1
Pingping Hu, Qiqi Liu, Guodong Deng, Jingxin Zhang, Ning Liang, Jian Xie, Jiandong Zhang
The outcomes of studies analyzing the prognostic role of CTLA-4 in cancers are controversial. Therefore, the aim of our meta-analysis was to clarify the correlation between CTLA-4 expression and OS in different cancer cases. Relevant literature was searched using PubMed, EMBASE, Web of Science, and the Cochrane Library. The clinicopathological features, hazard ratio (HR) and 95% confidence intervals (CI) were collected from these studies and were analyzed using Stata version 12.0 software. The pooled HR values showed no significant correlation between CTLA-4 expression levels and OS in relation to tumors (HR: 1...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211174/saitohin-q7r-polymorphism-is-associated-with-late-onset-alzheimer-s-disease-susceptibility-among-caucasian-populations-a-meta-analysis
#2
REVIEW
Rong Huang, Sai Tian, Rongrong Cai, Jie Sun, Wenqing Xia, Xue Dong, Yanjue Shen, Shaohua Wang
Saitohin (STH) Q7R polymorphism has been reported to influence the individual's susceptibility to Alzheimer's disease (AD); however, conclusions remain controversial. Therefore, we performed this meta-analysis to explore the association between STH Q7R polymorphism and AD risk. Systematic literature searches were performed in the PubMed, Embase, Cochrane Library and Web of Science for studies published before 31 August 2016. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of the association using a fixed- or random-effects model...
February 17, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28210493/reducing-the-blame-culture-through-clinical-audit-in-nuclear-medicine-a-mixed-methods-study
#3
P Ross, J Hubert, W L Wong
OBJECTIVES: To identify the barriers and facilitators of doctors' engagement with clinical audit and to explore how and why these factors influenced doctors' decisions to engage with the NHS National Clinical Audit Programme. DESIGN: A single-embedded case study. Mixed methods sequential approach with explorative pilot study and follow-up survey. Pilot study comprised 13 semi-structured interviews with purposefully selected consultant doctors over a six-month period...
February 2017: JRSM Open
https://www.readbyqxmd.com/read/28199970/three-single-nucleotide-polymorphisms-of-tnfaip3-gene-increase-the-risk-of-rheumatoid-arthritis
#4
Nan Shen, Yuan Ruan, Yajun Lu, Xuefeng Jiang, Huiqing Sun, Gongming Gao, Luming Nong, Kewei Ren
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic destructive inflammation in synovial joints. To date, many studies explored the associations between tumor necrosis factor alpha inducible protein 3 (TNFAIP3) gene rs6920220, rs2230926, and rs5029937 polymorphisms and the risk of rheumatoid arthritis (RA), but with contradictory results. We therefore conducted a comprehensive meta-analysis to address the associations. We searched in the databases of PubMed and Embase. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by the Stata 11...
February 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28196405/psychosocial-interventions-for-supporting-women-to-stop-smoking-in-pregnancy
#5
REVIEW
Catherine Chamberlain, Alison O'Mara-Eves, Jessie Porter, Tim Coleman, Susan M Perlen, James Thomas, Joanne E McKenzie
BACKGROUND: Tobacco smoking remains one of the few preventable factors associated with complications in pregnancy, and has serious long-term implications for women and babies. Smoking in pregnancy is decreasing in high-income countries, but is strongly associated with poverty and is increasing in low- to middle-income countries. OBJECTIVES: To assess the effects of smoking cessation interventions during pregnancy on smoking behaviour and perinatal health outcomes...
February 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28192247/comparison-of-peri-articular-liposomal-bupivacaine-and-standard-bupivacaine-for-postsurgical-analgesia-in-total-knee-arthroplasty-a-systematic-review-and-meta-analysis
#6
REVIEW
Xi Wang, Lin Xiao, Zhiyuan Wang, Guanghui Zhao, Jianbing Ma
OBJECTIVE: This meta-analysis aimed to compare the efficacy and safety of intraoperative peri-articular liposomal bupivacaine and standard bupivacaine in patients undergoing total knee arthroplasty. METHODS: A systematic search was performed in Medline (1966-2016.9), PubMed (1966-2016.9), Embase (1980-2016.9), ScienceDirect (1985-2016.9) and the Cochrane Library. Only high-quality studies were selected. Meta-analysis was performed using Stata 11.0 software. RESULTS: Three randomized controlled trials (RCTs) and two non-randomized controlled trials (Non-RCTs), including 1214 patients met the inclusion criteria...
February 10, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28191856/quantitative-assessment-of-the-effect-of-fgf20-rs12720208-variant-on-the-risk-of-parkinson-s-disease-a-meta-analysis
#7
Xiaoli Wang, Xiaoxuan Sun, Xiaona Zhang, Hong Li, Anmu Xie
OBJECTIVES: Many studies have investigated the association between fibroblast growth factor 20(FGF20) rs12720208(C/T) polymorphism and the susceptibility of Parkinson's disease (PD). However, published data are still controversial. Here, we performed a meta-analysis to evaluate the association of rs12720208 polymorphism with the risk of PD. METHODS: Up to April 2016, Pubmed, EMbase, Web of science, the Chinese National Knowledge Infrastructure, and Wanfang Medicine were reviewed to identify appropriate documents...
February 13, 2017: Neurological Research
https://www.readbyqxmd.com/read/28188721/pd-l1-over-expression-is-associated-with-a-poor-prognosis-in-asian-non-small-cell-lung-cancer-patients
#8
Haifeng Xia, Ji Shen, Fang Hu, Shaomu Chen, Haitao Huang, Yaozeng Xu, Haitao Ma
BACKGROUND: The prognostic role of programmed cell death-ligand 1 (PD-L1) in non-small cell lung cancer (NSCLC) remains controversial. This meta-analysis was conducted to clarify the association of PD-L1 with survival in NSCLC patients. METHODS: Relevant studies were collected from PubMed, Embase and Web of Science. Only studies in which PD-L1 expression was detected by immunohistochemical staining in NSCLC patients correlated with patient survival data were included...
February 7, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28188488/long-noncoding-rnas-as-novel-serum-biomarkers-for-the-diagnosis-of-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#9
C Zheng, H Hao, L Chen, J Shao
PURPOSE: Long noncoding RNAs (lncRNAs) are outstanding as novel cancer biomarkers with great prospects. Herein, we focused on summarizing the overall diagnostic evaluation of lncRNAs for hepatocellular carcinoma (HCC). METHODS: Relevant literature was collected from the online databases. The Quality Assessment for Studies of Diagnostic Accuracy checklist was used to assess the quality of included studies. The pooled sensitivity, specificity, and diagnostic odds ratio (DOR) were plotted using random-effects models...
February 10, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28187430/prognostic-significance-of-neutrophil-to-lymphocyte-ratio-in-cervical-cancer-a-systematic-review-and-meta-analysis-of-observational-studies
#10
Qi-Tao Huang, Qian-Qian Man, Jia Hu, Yi-Lin Yang, Yue-Mei Zhang, Wei Wang, Mei Zhong, Yan-Hong Yu
BACKGROUND AND AIMS: The prognostic role of neutrophil-to-lymphocyte ratio (NLR) in cervical cancer are controversial. We conducted this meta-analysis to obtain a more accurate assessment of prognostic significance of NLR in cervical cancer. RESULTS: A total of 9 studies, consisting of 2,804 patients, were selected in this meta-analysis. Our pooled results showed that high pre-treatment NLR level was significantly associated with poorer overall survival (HR: 1.88, 95% CI 1...
6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28185410/nlrp3-p-q705k-and-card8-p-c10x-single-nucleotide-polymorphisms-are-not-associated-with-susceptibility-to-rheumatoid-arthritis-a-meta-analysis
#11
Zhaowen Yang, Jin Cao, Qingrui Yang, Yuanchao Zhang, Lihui Han
AIM: Genetic factors have a substantial contribution to the pathogenesis of rheumatoid arthritis (RA). Single nucleotide polymorphisms of NLRP3 p.Q705K and CARD8 p.C10X are two gene mutations that have been linked to many diseases. Here we carried out a meta-analysis to identify their association with susceptibility to RA. METHOD: Relevant studies were identified from databases, including PubMed, Cochrane Library, EMBase, Elsevier Science Direct, Web of Science, SpringerLink, and so on...
February 9, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28180125/relationship-between-air-pollution-weather-traffic-and-traffic-related-mortality
#12
Maryam Dastoorpoor, Esmaeil Idani, Narges Khanjani, Gholamreza Goudarzi, Abbas Bahrampour
BACKGROUND: Air pollution and weather are just two of many environmental factors contributing to traffic accidents (RTA). OBJECTIVES: This study assessed the effects of these factors on traffic accidents and related mortalities in Ahvaz, Iran. METHODS: In this ecological study, data about RTA, traffic-related mortalities, air pollution (including NO, CO, NO2, NOx PM10, SO2, and O3 rates) and climate data from March 2008 until March 2015 was acquired from the Khuzestan State Police Force, the Environmental Protection Agency and the State Meteorological Department...
September 2016: Trauma Monthly
https://www.readbyqxmd.com/read/28180013/the-influence-of-internal-wall-and-floor-covering-materials-and-ventilation-type-on-indoor-radon-and-thoron-levels-in-hospitals-of-kermanshah-iran
#13
Meghdad Pirsaheb, Farid Najafi, Abbas Haghparast, Lida Hemati, Kiomars Sharafi, Nematullah Kurd
BACKGROUND: Building materials and the ventilation rate of a building are two main factors influencing indoor radon and thoron levels (two radioactive gases which have the most important role in human natural radiation exposure within dwellings). OBJECTIVES: This analytical descriptive study was intended to determine the relationship between indoor radon and thoron concentrations and the building materials used in interior surfaces, as well as between those concentrations and the type of ventilation system (natural or artificial)...
October 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28180012/seroprevalence-and-co-infection-of-human-immunodeficiency-virus-hiv-and-herpes-simplex-virus-hsv-among-pregnant-women-in-lokoja-north-central-nigeria
#14
Olatunji Matthew Kolawole, Oluwatomi Olufunke Amuda, Charles Nzurumike, Muhammed Mustapha Suleiman, Jeremiah Ikhevha Ogah
BACKGROUND: Herpes simplex virus 1 (HSV-1) is normally associated with orofacial (orolabial) infections and encephalitis, whereas HSV-2 usually causes genital infections and can be transmitted from infected mothers to neonates. The evidence suggesting that HSV is facilitating the spread of the global human immunodeficiency virus (HIV) epidemic and the risk posed by these synergies to neonates in developing countries informed this study. OBJECTIVES: To determine the seroprevalence and co-infection of HIV and HSV, as well as their associated risk factors, in Lokoja, Nigeria...
October 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28178935/pneumococcal-carriage-among-hiv-infected-children-in-accra-ghana
#15
Eric S Donkor, Jennifer A Annan, Ebenezer V Badoe, Nicholas T K D Dayie, Appiah-Korang Labi, Hans-Christian Slotved
BACKGROUND: Pneumococcal carriage is the precursor for development of pneumococcal disease, and is also responsible for transmission of the organism from person-to-person. In Africa, little is known about the pneumococcus in relation to people with HIV infection. The aim of the study was to investigate the epidemiology of pneumococcal carriage among HIV infected children visiting a tertiary hospital in Ghana, including the carriage prevalence, risk factors and serotype distribution. METHOD: This was a cross sectional study carried out from February to May, 2015 at the HIV Paediatric Clinic of the Korle-Bu Teaching Hospital in Accra, Ghana...
February 8, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28176953/survival-status-and-predictors-of-mortality-among-severely-acute-malnourished-children-5-years-of-age-admitted-to-stabilization-centers-in-gedeo-zone-a-retrospective-cohort-study
#16
Tadele Girum, Mesfin Kote, Befikadu Tariku, Henok Bekele
Despite the existence of standard protocol, many stabilization centers (SCs) continue to experience high mortality of children receiving treatment for severe acute malnutrition. Assessing treatment outcomes and identifying predictors may help to overcome this problem. Therefore, a 30-month retrospective cohort study was conducted among 545 randomly selected medical records of children <5 years of age admitted to SCs in Gedeo Zone. Data was entered by Epi Info version 7 and analyzed by STATA version 11. Cox proportional hazards model was built by forward stepwise procedure and compared by the likelihood ratio test and Harrell's concordance, and fitness was checked by Cox-Snell residual plot...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28176509/role-of-polymorphisms-of-gstm1-gstt1-and-gstp1-ile105val-in-childhood-acute-lymphoblastic-leukemia-all-risk-an-update-meta-analysis
#17
Tao Zhao, Fenglian Ma, Fangqing Yin
BACKGROUND: The association between glutathione-S-transferase polymorphisms (GSTM1, GSTT1 and GSTP1 Ile105Val) and risk of childhood acute lymphoblastic leukemia (ALL) remains controversial. Therefore, we performed a meta-analysis to derive a more precise estimation of the relationship. METHODS: We searched Medline (Mainly Pubmed), Embase, Cochrane Library, CNKI (Chinese National Knowledge Infrastructure), Chinese Biomedical Literature (Chinese) and Wanfang (Chinese) Databases to collect articles that evaluated the polymorphism of GSTs gene in child patients with ALL...
February 7, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28176187/brucellosis-and-associated-risk-factors-in-dairy-cattle-of-eastern-ethiopia
#18
Yitagele Terefe, Sisay Girma, Negesse Mekonnen, Biruhtesfa Asrade
Knowing the status of Bovine brucellosis and associated risk factors is a crucial step in formulating evidence based control scheme. In this study, a total of 967 dairy cows from 307 dairy farms in eastern Ethiopia were serologically tested for Brucella antibodies. The screening was done first using RBPT and positive samples were subsequently subjected to CFT for confirmation. A pre-tested structured questionnaire was used to collect relevant data from 307 dairy cattle owners or attendants to assess their awareness and routine practice...
February 7, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28169977/meta-analysis-of-odds-ratios-current-good-practices
#19
Bei-Hung Chang, David C Hoaglin
BACKGROUND: Many systematic reviews of randomized clinical trials lead to meta-analyses of odds ratios (ORs). The customary methods of estimating an overall OR involve weighted averages of the individual trials' estimates of the logarithm of the OR. That approach, however, has several shortcomings, arising from assumptions and approximations, that render the results unreliable. Although the problems have been documented in the literature for many years, the conventional methods persist in software and applications...
February 6, 2017: Medical Care
https://www.readbyqxmd.com/read/28168215/incidence-and-etiology-of-surgical-site-infections-among-emergency-postoperative-patients-in-mbarara-regional-referral-hospital-south-western-uganda
#20
Abubaker Lubega, Bazira Joel, Najjuka Justina Lucy
Background. This prospective hospital based study was conducted to determine the incidence, risk factors, and causative agents of surgical site infection their susceptibility to among 114 emergency postoperative patients at the Mbarara Regional Referral Hospital between September 2014 and January 2015. Methods. Consented patients were consecutively enrolled and their preoperative, intraoperative, and postoperative data were collected. Follow-ups were done in the surgical outpatient clinics. Wound specimens were collected and processed as per Sops; susceptibility testing was done using the Kirby-Bauer disc diffusion technique...
2017: Surgery Research and Practice
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