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https://www.readbyqxmd.com/read/28108740/positive-expression-of-y-box-binding-protein-1-and-prognosis-in-non-small-cell-lung-cancer-a-meta-analysis
#1
Liang Jiang, Gao-Le Yuan, Qi-Lian Liang, Hui-Jie Zhang, Jie Huang, Shao-Ang Cheng, Xiao-Xia Peng
BACKGROUND: Y-box binding protein 1 (YB-1) belongs to the cold shock domain protein family involved in transcription and translation. We conducted a meta-analysis of the association between YB-1 expression and the survival and clinicopathological features in NSCLC. METHODS: PubMed and Embase were searched to identify studies that evaluated the YB-1 expression (by immunohistochemistry) and overall survival (OS) in NSCLC. Hazard ratios (HRs) and 95% confidence intervals (CI) of OS were pooled...
January 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28108451/gwar-robust-analysis-and-meta-analysis-of-genome-wide-association-studies
#2
Niki L Dimou, Konstantinos D Tsirigos, Arne Elofsson, Pantelis G Bagos
MOTIVATION: In the context of genome-wide association studies (GWAS), there is a variety of statistical techniques in order to conduct the analysis, but, in most cases, the underlying genetic model is usually unknown. Under these circumstances, the classical Cochran-Armitage trend test is suboptimal. Robust procedures that maximize the power and preserve the nominal type I error rate are preferable. Moreover, performing a meta-analysis using robust procedures is of great interest and has never been addressed in the past...
January 20, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28107500/diagnostic-efficacy-of-sentinel-lymph-node-biopsy-in-early-oral-squamous-cell-carcinoma-a-meta-analysis-of-66-studies
#3
Muyuan Liu, Steven J Wang, Xihong Yang, Hanwei Peng
OBJECTIVES: The diagnostic efficacy of sentinel lymph node biopsy(SLNB) in early oral squamous cell carcinoma(OSCC) still remains controversial. This meta-analysis was conducted to assess the diagnostic value of SLNB in clinically neck-negative T1-2 OSCC. METHODS: A systematic literature search for relevant literature published up to September 11, 2016 was conducted in PubMed, Embase, Web of Science, Cochrane Library and ClinicalTrials, and the reference lists of eligible studies were examined...
2017: PloS One
https://www.readbyqxmd.com/read/28103718/peer-review-improves-psychometric-characteristics-of-multiple-choice-questions
#4
Hani Abozaid, Yoon Soo Park, Ara Tekian
PURPOSE: For new and emerging medical schools, developing a system to peer-review and evaluate the assessment processes through faculty development programs can be a challenge. This study evaluates the impact of peer-review practices on item analysis, reliability, and the standard error of measurement of multiple-choice questions for summative final examinations. METHODS: This study used a retrospective cohort design of two consecutive academic years in 2012 and in 2013...
January 20, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28100207/rate-and-associated-factors-of-non-retention-of-mother-baby-pairs-in-hiv-care-in-the-elimination-of-mother-to-child-transmission-programme-gulu-uganda-a-cohort-study
#5
Gerald Obai, Ruth Mubeezi, Fredrick Makumbi
BACKGROUND: Poor retention in HIV care of mother-baby pairs remains a public health challenge in the elimination of mother-to-child transmission (eMTCT) of HIV. We determined the rate of non-retention and time to non-retention of mother-baby pairs and associated factors in Gulu district, Northern Uganda. METHODS: Mother-baby pairs enrolled into the eMTCT programme at Gulu Regional Referral Hospital (GRRH) and Lacor Hospital (LH) were retrospectively followed for 18 months...
January 18, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28099923/significant-association-between-let-7-kras-rs712-g-t-polymorphism-and-cancer-risk-in-the-chinese-population-a-meta-analysis
#6
Xin-Ya Du, Yuan-Yuan Hu, Chun Xie, Chun-Yan Deng, Cai-Yun Liu, Zhi-Guo Luo, Yu-Ming Niu, Ming Shen
Association between let-7-KRAS rs712 polymorphism and cancer risk was inconsistent. We therefore conducted this meta-analysis to clarify the association between let-7-KRAS rs712 polymorphism and cancer risk with STATA 14.0 software. A systemic literature search in online databases (PubMed, Embase, CNKI and Wanfang database) was preformed to obtain relevant articles. A total of 13 case-control studies involving 3,453 patients and 4,470 controls were identified up to May 16, 2015. The pooled results indicated that significantly increased risk were observed in Chinese population in T vs...
16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28099908/the-association-of-two-polymorphisms-in-adiponectin-encoding-gene-with-hypertension-risk-and-the-changes-of-circulating-adiponectin-and-blood-pressure-a-meta-analysis
#7
Jianmin Wu, Guoyan Xu, Wenqin Cai, Yun Huang, Ningyu Xie, Yihua Shen, Liangdi Xie
OBJECTIVES: This meta-analysis was prepared to synthesize published data on the association of two polymorphisms (T45G and G276T) in adiponectin-encoding gene (ADIPOQ) with hypertension risk and the changes of circulating adiponectin and blood pressure.Methodology and Major Findings: Data were collected and corrected by two authors, and were managed with Stata software. In total, 12 articles were synthesized, including 12 studies (3358 cases and 5121 controls) for the association of two study polymorphisms with hypertension risk and 11 studies (3053 subjects) for the between-genotype changes of adiponectin and/or blood pressure...
January 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28099347/prediction-of-risk-of-diabetic-retinopathy-for-all-cause-mortality-stroke-and-heart-failure-evidence-from-epidemiological-observational-studies
#8
Xiao-Rong Zhu, Yong-Peng Zhang, Lu Bai, Xue-Lian Zhang, Jian-Bo Zhou, Jin-Kui Yang
To examine and quantify the potential relation between diabetic retinopathy (DR) and risk of all-cause mortality, stroke and heart failure (HF).The resources of meta-analysis of epidemiological observational studies were from Pub-med, EMBASE, CINAHL, Cochrane Library, conference, and proceedings.Random/fixed effects models were used to calculate pooled subgroup analysis stratified by different grades of DR was performed to explore the potential source of heterogeneity. Statistical manipulations were undertaken using program STATA...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28098080/access-to-healthcare-among-the-empowered-action-group-eag-states-of-india-current-status-and-impeding-factors
#9
Virendra Kumar, Pushpendra Singh
BACKGROUND: Access to healthcare is crucial for meeting the health needs of Indians. We explored factors impeding access to public sources of healthcare among the Empowered Action Group (EAG) states of India. We also examined the extent to which Indians depend on public and private sources of healthcare in the EAG states. METHODS: Our study is based on the unit-level records of 9988 ailing persons, who were surveyed among the EAG states in the 71st round of the National Sample Survey (NSS), conducted during January-June 2014 on the theme 'Social consumption: Health'...
September 2016: National Medical Journal of India
https://www.readbyqxmd.com/read/28097657/public-trust-in-health-information-sharing-a-measure-of-system-trust
#10
Jodyn E Platt, Peter D Jacobson, Sharon L R Kardia
OBJECTIVE: To measure public trust in a health information sharing in a broadly defined health system (system trust), inclusive of health care, public health, and research; to identify individual characteristics that predict system trust; and to consider these findings in the context of national health initiatives (e.g., learning health systems and precision medicine) that will expand the scope of data sharing. DATA SOURCES: Survey data (n = 1,011) were collected in February 2014...
January 18, 2017: Health Services Research
https://www.readbyqxmd.com/read/28095100/association-of-combined-cigarette-smoking-and-arms2-loc387715-a69s-polymorphisms-with-age-related-macular-degeneration-a-meta-analysis
#11
Mohammad Hossein Jabbarpoor Bonyadi, Mehdi Yaseri, Mortaza Bonyadi, Masoud Soheilian, Homayoun Nikkhah
PURPOSE: The age-related maculopathy susceptibility2 (ARMS2)/LOC387715 A69S (rs10490924) polymorphism and cigarette smoking have been shown to have significant association with AMD. In this meta-analysis we used the results of available association studies of combined ARMS2/LOC387715 genotypes and cigarette smoking with AMD to estimate the possible synergistic or multiplicative effects. METHODS: Heterogeneity of studies was evaluated using the Cochran Q-test and the I-square index...
January 17, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28093970/evaluation-of-salivary-vitamin-c-and-catalase-in-hiv-positive-and-healthy-hiv-negative-control-group
#12
Fatemeh Ahmadi Motamayel, Samaneh Vaziri Amjad, Mohammad Taghi Goodarzi, Jalal Poorolajal
BACKGROUND: Saliva is a complex oral biologic fluid from major and minor salivary glands. Saliva has immunological, enzymatic and antioxidant defense mechanisms. Infection with human immunodeficiency virus (HIV) is life threatening disease. OBJECTIVE: The aim of this study was evaluation of salivary vitamin C and catalase level in HIV positive patients in comparison to healthy control group. METHOD: Forty nine HIV infected person and 49 healthy subjects were selected...
January 16, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28090349/the-association-between-parental-separation-during-childhood-and-obesity-in-adulthood-a-danish-twin-study
#13
J D Petersen, K O Kyvik, B L Heitmann, M E Vámosi
OBJECTIVE: The purpose of this study was to examine if parental separation during childhood is associated with obesity in adulthood. METHODS: A co-twin case-control study of 146 adult same-sexed twin pairs with discordant body mass index (BMI) (i.e. one of the twins should have a BMI of 20-25 kg/m(2), and the co-twin's BMI ≥ 30 kg/m(2)) was selected from Danish Twin Registry (DTR). In total of 236 eligible twin individuals participated in the study. Childhood parental separation (defined as separation from one of the biological parents, regardless of the reason for separation) for at least one year prior to age 17 was self-reported...
December 2016: Obesity Science & Practice
https://www.readbyqxmd.com/read/28088029/an-updated-meta-analysis-of-cohort-studies-diabetes-and-risk-of-alzheimer-s-disease
#14
REVIEW
Jieyu Zhang, Chunxiang Chen, Shuizhen Hua, Hairong Liao, Meixiang Wang, Yan Xiong, Fei Cao
BACKGROUND: In recently, several large longitudinal population-based studies have shown that the rate of cognitive decline is accelerated in elderly people with diabetes mellitus. But the relation between diabetes and AD is still an area of controversy. The objective of this review was to update the evidence for or against diabetes as a risk factor of AD. METHODS: We searched the literature from their inception to May 2016 without restriction of language. We included all longitudinal population-based studies examining the association between diabetes and risk of AD...
November 9, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28087414/consumption-of-low-calorie-sweeteners-among-children-and-adults-in-the-united-states
#15
Allison C Sylvetsky, Yichen Jin, Elena J Clark, Jean A Welsh, Kristina I Rother, Sameera A Talegawkar
BACKGROUND: Consumption of low-calorie sweeteners (LCSs) has increased markedly during the past several decades, yet the prevalence of LCS consumption in recent years is currently unknown. OBJECTIVE: The aim of this study was to describe LCS consumption in the United States and to characterize consumption by sociodemographic subgroups, source, frequency, eating occasion, and location. DESIGN: Cross-sectional study using National Health and Nutrition Examination Survey data from 2009 to 2012...
January 6, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28087187/gender-ratio-trends-over-time-in-multiple-sclerosis-patients-from-argentina
#16
J I Rojas, L Patrucco, J MIguez, V Sinay, F Pagani Cassara, F Cáceres, N Fernandez Liguori, M L Saladino, N Deri, G Jaacks, M Parada Marcilla, M I Arrigoni, J Correale, M Fiol, M C Ysrraelit, A Carrá, M C Curbelo, A Martinez, J Steinberg, S Bestoso, J P Hryb, J L Di Pace, M B Perassolo, E Carnero Contentti, A Caride, P A Lopez, C Martinez, E Reich, D Giunta, E Cristiano
: Several studies in multiple sclerosis (MS) suggest a trend of increasing disease frequency in women during the last decades. A direct comparison of gender ratio trends among MS populations from Argentina remains to be carried out. The objective of the study was to compare gender ratio trends, over a 50-year span in MS populations from Argentina. METHODS: multicenter study that included patients from 14 MS Centers of Argentina. Patients with definite MS with birth years ranging from 1940 to 1989 were included...
January 10, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28086970/trends-determinants-and-inequities-of-4-anc-utilisation-in-bangladesh
#17
Aminur Rahman, Monjura Khatun Nisha, Tahmina Begum, Sayem Ahmed, Nurul Alam, Iqbal Anwar
BACKGROUND: The objectives of this study are to document the trend on utilisation of four or more (4(+)) antenatal care (ANC) over the last 22 years period and to explore the determinants and inequity of 4(+) ANC utilisation as reported by the last two Bangladesh Demographic and Health surveys (BDHS) (2011 and 2014). METHODS: The data related to ANC have been extracted from the BDHS data set which is available online as an open source. STATA 13 software was used for organising and analysing the data...
January 13, 2017: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/28086961/longitudinal-multiple-imputation-approaches-for-body-mass-index-or-other-variables-with-very-low-individual-level-variability-the-mibmi-command-in-stata
#18
Evangelos Kontopantelis, Rosa Parisi, David A Springate, David Reeves
BACKGROUND: In modern health care systems, the computerization of all aspects of clinical care has led to the development of large data repositories. For example, in the UK, large primary care databases hold millions of electronic medical records, with detailed information on diagnoses, treatments, outcomes and consultations. Careful analyses of these observational datasets of routinely collected data can complement evidence from clinical trials or even answer research questions that cannot been addressed in an experimental setting...
January 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28081316/evaluation-of-epidemiological-characteristics-and-risk-factors-affecting-mortality-in-patients-with-candidemia
#19
Fatma Yılmaz Karadağ, Pınar Ergen, Özlem Aydın, Arzu Doğru, Berrin Tanıdır, Mustafa Haluk Vahaboğlu
BACKGROUND/AIM: The aim of this study was to determine epidemiologic characters of patients with candidemia and to evaluate risk factors that can affect mortality rates among these patients. MATERIALS AND METHODS: Patients admitted to the İstanbul Medeniyet University Göztepe Training Hospital between 2009 and 2011 who had a positive blood culture for Candida spp. during hospitalization were studied retrospectively for demographic characteristics and risk factors...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28081192/circulating-betatrophin-levels-and-gestational-diabetes-mellitus-a-systematic-review-and-meta-analysis
#20
Fei-Juan Kong, Lei-Lei Ma, Ge Li, Yi-Xin Chen, Jia-Qiang Zhou
OBJECTIVE: The association between circulating betatrophin levels and gestational diabetes mellitus (GDM) is controversial. The aim of our study was to systematically review available literature linking betatrophin to GDM for a comprehensive understanding of the relationship between circulating betatrophin levels and GDM in human. METHODS: PubMed, The Cochrane Library, Medline and CNKI were searched for studies published up to August 2016. Manual searches of references of the relevant original studies were conducted...
2017: PloS One
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