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https://www.readbyqxmd.com/read/28445317/timing-of-tourniquet-release-in-total-knee-arthroplasty-a-meta-analysis
#1
Pei Zhang, Yuan Liang, Jinshan He, Yongchao Fang, Pengtao Chen, Jingcheng Wang
BACKGROUND: For total knee arthroplasty (TKA), the tourniquet is routinely employed for better visualization, less blood loss, and easier cementation. However, the time to release tourniquet remains controversial. Therefore, we performed current meta-analysis to assess whether releasing tourniquet before wound closure is more effective in reducing blood loss than releasing tourniquet after wound closure in TKA without an increased risk of complications. METHODS: To conduct this meta-analysis, we searched Medline, Embase, Web of science, and the Cochrane library up to November 2016, for randomized controlled trials comparing tourniquet releasing before and after wound closure in TKA...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445294/unilateral-versus-bilateral-percutaneous-kyphoplasty-for-osteoporotic-vertebral-compression-fractures-a-meta-analysis
#2
Wenli Chang, Xinyan Zhang, Ning Jiao, Peizhi Yuwen, Yanbin Zhu, Fei Zhang, Wei Chen
BACKGROUND: The debate on the efficacy of unilateral percutaneous kyphoplasty (UPKP) and bilateral percutaneous kyphoplasty (BPKP) for the treatment of osteoporotic vertebral compression fractures (OVCFs) is ongoing.This meta-analysis aimed to evaluate the clinical results of UPKP and BPKP in the treatment of OVCFs. METHODS: Web of Science, PubMed, Embase, and the Chinese Biomedical Database publication databases were searched using a date range of January 2008 to November 2016, for studies comparing UPKP and BPKP for the treatment of OVCFs...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445279/promoter-hypermethylation-of-mgmt-gene-may-contribute-to-the-pathogenesis-of-gastric-cancer-a-prisma-compliant-meta-analysis
#3
Zongxin Zhang, Shaojun Xin, Min Gao, Yunxiang Cai
BECKGROUND: The association of MGMT (O-methyguanine deoxyribonucleic acid methyltransferase) promoter hypermethylation with gastric cancer (GC) risk has been studied extensively, but the results remained unclear. Here, we performed a meta-analysis to evaluate whether promoter hypermethylation of the MGMT gene contributed to gastric pathogenesis. METHODS: Relevant studies were identified by retrieving the PubMed, Web of Science, Embase, and China National Knowledge Infrastructure (CNKI) databases...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28442913/fracture-risk-in-patients-with-type-2-diabetes-mellitus-and-possible-risk-factors-a-systematic-review-and-meta-analysis
#4
REVIEW
Ardeshir Moayeri, Mahmoud Mohamadpour, Seyedeh Fatemeh Mousavi, Ehsan Shirzadpour, Safoura Mohamadpour, Mansour Amraei
AIM: Patients with type 2 diabetes mellitus (T2DM) have an increased risk of bone fractures. A variable increase in fracture risk has been reported depending on skeletal site, diabetes duration, study design, insulin use, and so on. The present meta-analysis aimed to investigate the association between T2DM with fracture risk and possible risk factors. METHODS: Different databases including PubMed, Institute for Scientific Information, and Scopus were searched up to May 2016...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28441396/prognostic-significance-of-neutrophil-to-lymphocyte-ratio-in-diffuse-large-b-cell-lymphoma-a-meta-analysis
#5
Jin Wang, Xu Zhou, Yu Liu, Zheng Li, Xiang Li
BACKGROUND: Neutrophil-to-lymphocyte ratio (NLR) has been investigated as a prognostic marker in patients with diffuse large B-cell lymphoma (DLBCL); however, the results remain controversial. This study aimed to explore the association between NLR and survival outcomes and clinicopathological factors in DLBCL. METHODS: Relevant studies were retrieved by searching PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) databases. The last search was updated on February 17, 2017...
2017: PloS One
https://www.readbyqxmd.com/read/28440324/lutetium-177-labelled-anti-prostate-specific-membrane-antigen-antibody-and-ligands-for-the-treatment-of-metastatic-castrate-resistant-prostate-cancer-a-systematic-review-and-meta-analysis
#6
R J S Calopedos, V Chalasani, R Asher, L Emmett, H H Woo
BACKGROUND: Promising therapeutic results of the prostate-specific membrane antigen (PSMA) ligand have been shown when labelling with lutetium-177 ((177)Lu). We performed a systematic review and meta-analysis to assess the therapeutic response of (177)Lu-PSMA in the treatment of metastatic castration-resistant prostate cancer (mCRPC). METHODS: A systematic review was conducted using electronic databases up to December 2016. Two reviewers independently extracted data and assessed methodological quality...
April 25, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28439419/chronic-complications-and-quality-of-life-of-patients-living-with-sickle-cell-disease-and-receiving-care-in-three-hospitals-in-cameroon-a-cross-sectional-study
#7
Anne M Andong, Eveline D T Ngouadjeu, Cavin E Bekolo, Vincent S Verla, Daniel Nebongo, Yannick Mboue-Djieka, Simeon-Pierre Choukem
BACKGROUND: Sickle Cell Disease (SCD) is associated with chronic multisystem complications that significantly influence the quality of life (QOL) of patients early in their life. Although sub-Saharan Africa bears 75% of the global burden of SCD, there is a paucity of data on these complications and their effects on the QOL. We aimed to record these chronic complications, to estimate the QOL, and to identify the corresponding risk factors in patients with SCD receiving care in three hospitals in Cameroon...
2017: BMC Hematology
https://www.readbyqxmd.com/read/28439071/diabetes-mellitus-and-the-risk-of-multidrug-resistant-tuberculosis-a-meta-analysis
#8
Qianqian Liu, Wenzhang Li, Miao Xue, Yunfeng Chen, Xinmiao Du, Chengdi Wang, Lina Han, Yin Tang, Yulin Feng, Chuanmin Tao, Jian-Qing He
The high prevalence of diabetes mellitus (DM) among multidrug resistant tuberculosis (MDR-TB) patients is a serious cause for concern. We conducted a meta-analysis to determine whether DM is an independent risk factor for MDR-TB. Electronic literature searches of the PubMed, Web of Science and EMBASE databases up to July 12, 2016 were conducted. The pooled adjusted odds ratio (OR) and 95% confidence intervals (CIs) were calculated using the random effects model with STATA 12.0 software. In total 13 studies, including 9289 individuals with TB, were included in this meta-analysis...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28438158/prevalence-of-helicobacter-pylori-infection-among-children-living-in-a-rural-setting-in-sub-saharan-africa
#9
Yaw Asante Awuku, David Larbi Simpong, Ishmael Kunateh Alhassan, Derek Anamaale Tuoyire, Taiba Afaa, Patrick Adu
BACKGROUND: Helicobacter pylori infection affects more than half of the world's population. It is generally acquired during childhood with no symptoms but has long- term clinical sequelae. This study estimated the prevalence of H. pylori infection amongst children in a rural environment in Africa. METHODS: We conducted a cross-sectional study over a four (4)-month period within two rural communities. 240 asymptomatic children were tested using lateral flow immunochromatographic assay for the qualitative detection of H...
April 24, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28432513/the-relationship-between-statins-and-breast-cancer-prognosis-varies-by-statin-type-and-exposure-time-a-meta-analysis
#10
EDITORIAL
Binliang Liu, Zongbi Yi, Xiuwen Guan, Yi-Xin Zeng, Fei Ma
PURPOSE: Breast cancer is the most common cancer in females and the leading cause of death worldwide. The effects of statins on breast cancer prognosis have long been controversial; thus, it is important to investigate the relationship between statin type, exposure time, and breast cancer prognosis. This study sought to explore the effect of statins, as well as the different effects of statin solubility and variable follow-up times, on breast cancer prognosis. METHODS: We searched the MEDLINE (via PubMed), EMBASE (via OvidSP), Cochrane Library, and ISI Web of Knowledge databases using combinations of the terms "breast neoplasms[MeSH]," "statins" or "lipid-lowering drug," "prognosis" or "survival," or "mortality" or "outcome" with no limit on the publication date...
April 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28418854/association-between-the-brca2-rs144848-polymorphism-and-cancer-susceptibility-a-meta-analysis
#11
REVIEW
Qiuyan Li, Rongwei Guan, Yuandong Qiao, Chang Liu, Ning He, Xuelong Zhang, Xueyuan Jia, Haiming Sun, Jingcui Yu, Lidan Xu
The BRCA2 gene plays an important role in cancer carcinogenesis, and polymorphisms in this gene have been associated with cancer risk. The BRCA2 rs144848 polymorphism has been associated with several cancers, but results have been inconsistent. In the present study, a meta-analysis was performed to assess the association between the rs144848 polymorphism and cancer risk. Literature was searched from the databases of PubMed, Embase and Google Scholar before April 2016. The fixed or random effects model was used to calculate pooled odd ratios on the basis of heterogeneity...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415653/association-between-hif1a-rs11549465-polymorphism-and-risk-of-prostate-cancer-a-meta-analysis
#12
REVIEW
Xiao-Dong Li, Hao Zi, Cheng Fang, Xian-Tao Zeng
The hypoxia inducible factor 1-alpha (HIF1A) gene has been suggested to play a critical role in cancer progression, and the relationship between HIF1A rs11549465 polymorphism and risk of prostate cancer has been investigated in previous studies. Nevertheless, conflicting results have been obtained. Hence, we reevaluated this issue by means of this meta-analysis, with the purpose of providing more precise conclusion on this issue. The electronic databases of PubMed, EMBASE and Chinese National Knowledge Infrastructure (CNKI) as well as other sources were searched for relevant reports concerning on the role of HIF1A rs11549465 polymorphism in the occurrence of prostate cancer...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414788/patients-with-subclinical-hypothyroidism-before-20-weeks-of-pregnancy-have-a-higher-risk-of-miscarriage-a-systematic-review-and-meta-analysis
#13
Yibing Zhang, Haoyu Wang, Xifeng Pan, Weiping Teng, Zhongyan Shan
OBJECTIVE: To evaluate the relationship between subclinical hypothyroidism (SCH) and the risk of miscarriage before 20 weeks of pregnancy. METHODS: Literature databases were searched, including the PubMed, Web of Science, Embase and Cochrane databases, from January 1, 1980, to December 31, 2015. The following search terms were used: subclinical hypothyroidism, hypothyroidism, thyroid dysfunction, thyroid hypofunction, subclinical thyroid disease, thyroid dysfunction, pregnancy loss, abortion and miscarriage...
2017: PloS One
https://www.readbyqxmd.com/read/28411169/the-impact-of-immunogenicity-of-tnf%C3%AE-inhibitors-in-autoimmune-inflammatory-disease-a-systematic-review-and-meta-analysis
#14
REVIEW
Valentina Pecoraro, Elena De Santis, Alessandra Melegari, Tommaso Trenti
BACKGROUND: Monoclonal antibodies drugs directed against TNFα, TNFα inhibitors, are immunogenic, and consequent anti-drug antibodies (ADA) formation may decrease the functional drug concentration, resulting in a loss of response. We evaluated the impact of ADA on TNFα therapeutic response. METHODS: We considered studies enrolling adult patients affected by autoimmune inflammatory disease in therapy with TNFα inhibitors. We collected data about study and population characteristics, treatment dosage, determination of ADA and adverse events (AE)...
April 11, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28410172/adolescent-and-young-adult-cancer-survivorship-educational-programming-a-qualitative-evaluation
#15
Deborah Vollmer Dahlke, Kayla Fair, Yan Alicia Hong, Debra Kellstedt, Marcia G Ory
BACKGROUND: This program evaluation considers the need for increased professional and patient education for adolescent and young adult (AYA) cancer survivorship. Due to the high incidence of late effects of cancer treatment among AYA cancer survivors, knowledge sharing and communications are needed throughout the transition from cancer care into community care. AYA survivors are likely to need developmentally appropriate psychosocial care as well as extensive follow-on surveillance by physicians who are educated and aware of the likely chronic conditions and late effects that may occur in these patients...
February 10, 2017: JMIR Cancer
https://www.readbyqxmd.com/read/28409164/health-related-quality-of-life-in-iranian-elderly-citizens-a-systematic-review-and-meta-analysis
#16
REVIEW
Mohammad Farajzadeh, Reza Ghanei Gheshlagh, Kourosh Sayehmiri
BACKGROUND: The ever-growing elderly population of Iran and their physical and mental consequences put emphasis on the necessity of determining the quality of life (QoL) in this social group. This systematic review and meta-analysis aimed to estimate the mean score of QoL in Iranian elderly citizens. METHODS: Twenty-one articles that were indexed in Iranian (MagIran and Iran Medex) and international (Scientific Information Database, Google Scholars, Science Direct, PubMed, ProQuest, Scopus) databases were selected...
April 2017: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/28408887/evaluation-of-salivary-and-serum-antioxidant-and-oxidative-stress-statuses-in-patients-with-chronic-periodontitis-a-case-control-study
#17
Fatemeh Ahmadi-Motamayel, Mohammad T Goodarzi, Zohreh Jamshidi, Reza Kebriaei
Aim: Local bacteria stimulate polymorphonuclear neutrophils to release reactive oxygen species in periodontitis. Increased levels of oxidative stress play a significant role in the pathogenesis of periodontitis. Therefore, this study aimed to evaluate total salivary and serum antioxidant capacity and malondialdehyde in patients with chronic periodontitis. Materials and methods: Fifty-five healthy subjects and 55 patients with chronic periodontitis, with an age range of 30-50 years, were evaluated. After clinical examination and case selection, unstimulated whole saliva was collected in the morning...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28407024/the-prognosis-of-infective-endocarditis-treated-with-biological-valves-versus-mechanical-valves-a-meta-analysis
#18
Ende Tao, Li Wan, WenJun Wang, YunLong Luo, JinFu Zeng, Xia Wu
OBJECTIVE: Surgery remains the primary form of treatment for infective endocarditis (IE). However, it is not clear what type of prosthetic valve provides a better prognosis. We conducted a meta-analysis to compare the prognosis of infective endocarditis treated with biological valves to cases treated with mechanical valves. METHODS: Pubmed, Embase and Cochrane databases were searched from January 1960 to November 2016.Randomized controlled trials, retrospective cohorts and prospective studies comparing outcomes between biological valve and mechanical valve management for infective endocarditis were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28406421/advantages-and-disadvantages-of-using-the-prisma7-to-determine-the-elderly-subjects-for-whom-the-smaf-is-useful-for-assessing-functional-status-in-bobo-dioulasso-burkina-faso
#19
A Berthé, M A S Somda, L Berthé-Sanou, B Konaté, H Hien, E Bayala, F Tou, M Drabo, F Badini-Kinda, J Macq
One of the difficulties faced by African actors working with the elderly is the lack of appropriate tools for the identification and/or diagnosis of functional disabilities among older people in this limited-resource (material, human, and financial) setting. This study sought to assess the advantages and disadvantages of the combined use of two tools, PRISMA7 (for identifying older individuals at risk of functional disabilities and loss of autonomy) and SMAF (to evaluate the functional status of the elderly) in Bobo-Dioulasso (Burkina Faso)...
February 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28404579/glycemic-index-glycemic-load-and-blood-pressure-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#20
Charlotte El Evans, Darren C Greenwood, Diane E Threapleton, Chris P Gale, Christine L Cleghorn, Victoria J Burley
Background: High blood pressure is a strong risk factor for cardiovascular disease.Objective: The aim of this study was to determine the associations of dietary glycemic index (GI) and glycemic load (GL) with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in healthy individuals.Design: A systematic review and meta-analysis of randomized controlled trials (RCTs) was carried out. Databases were searched for eligible RCTs in 2 phases. MEDLINE, Embase, CAB Abstracts, BIOSIS, ISI Web of Science, and the Cochrane Library were searched from January 1990 to December 2009...
April 12, 2017: American Journal of Clinical Nutrition
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