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chronic kidney disease complications

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https://www.readbyqxmd.com/read/28527200/contrast-enhanced-ultrasound-ceus-in-renal-imaging-at-an-interdisciplinary-ultrasound-centre-possibilities-of-dynamic-microvascularisation-and-perfusion
#1
Franz Josef Putz, Anna Erlmeier, Isabel Wiesinger, Niklas Verloh, Christian Stroszczynski, Bernhard Banas, Ernst Michael Jung
OBJECTIVE: To identify the indications for CEUS in renal imaging in an interdisciplinary ultrasound department. METHODS: 102 CEUS examinations of the kidney in 82 patients between September 2014 and July 2016 were analysed regarding the indication for ultrasound. CEUS was performed by one experienced sonographer agent after bolus injection of 1.0 up to 2.4 ml sulphur hexafluoride microbubbles using multifrequency probes with Contrast Harmonic imaging. RESULTS: CEUS of the kidney was performed in patients from 20 to 87 years...
May 19, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28520799/nonenzymatic-glycosylation-of-human-serum-albumin-and-its-effect-on-antibodies-profile-in-patients-with-diabetes-mellitus
#2
Alok Raghav, Jamal Ahmad, Khursheed Alam
BACKGROUND: Albumin glycation and subsequent formation of advanced glycation end products (AGEs) correlate with diabetes and associated complications. METHODS: Human Serum Albumin (HSA) was modified with D-glucose for a 40 day period under sterile conditions at 37°C. Modified samples along with native HSA (unmodified) were analyzed for structural modifications by UV and fluorescence, FTIR, Liquid chromatography mass spectrometry (LCMS) and X-ray crystallography...
2017: PloS One
https://www.readbyqxmd.com/read/28518414/systematic-review-of-surgical-and-medical-treatment-for-tertiary-hyperparathyroidism
#3
REVIEW
R R Dulfer, G J H Franssen, D A Hesselink, E J Hoorn, C H J van Eijck, T M van Ginhoven
BACKGROUND: A significant proportion of patients with chronic kidney disease and secondary hyperparathyroidism (HPT) remain hyperparathyroid after kidney transplantation, a state known as tertiary HPT. Without treatment, tertiary HPT can lead to diminished kidney allograft and patient survival. Parathyroidectomy was commonly performed to treat tertiary HPT until the introduction of the calcimimetic drug, cinacalcet. It is not known whether surgery or medical treatment is superior for tertiary HPT...
June 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28509429/chronic-kidney-disease-a-likely-underestimated-component-of-multimorbidity-in-older-patients-with-chronic-obstructive-pulmonary-disease
#4
REVIEW
Andrea Corsonello, Filippo Aucella, Claudio Pedone, Raffaele Antonelli-Incalzi
The coexistence of chronic kidney disease and chronic obstructive pulmonary disease, two age-related conditions, has important clinical and prognostic implications. Respiratory failure is associated with important changes in glomerular and tubulointerstitial function. In contrast, renal failure can affect lung function, mainly by adding a restrictive component or causing complications, such as uremic pulmonary edema and pleural effusion. The effect of age on renal and pulmonary function adds to the complexity of the interplay between the kidney and the lung in these patients...
May 16, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28508961/bacteremic-kidney-cyst-infection-caused-by-helicobacter-cinaedi
#5
Kenta Ito, Takumi Yamamoto, Haruomi Nishio, Asako Sawaya, Masaaki Murakami, Akiko Kitagawa, Yoko Matsuo, Ken Matsuo, Satoshi Tanaka, Noriko Mori
Cyst infection is one of the major complications in patients with autosomal dominant polycystic kidney disease (ADPKD). The causative pathogen in kidney cyst infection frequently goes undetected. Although only one case report of kidney cyst infection caused by Helicobacter cinaedi (H. cinaedi) is published in English literature, it may be an important pathogen in kidney cyst infection. Kidney cyst infection and H. cinaedi infection share the common characteristic of tendency to relapse and chronic kidney disease is a major risk factor for H...
November 2016: CEN Case Reports
https://www.readbyqxmd.com/read/28508131/muscle-wasting-in-chronic-kidney-disease
#6
Eduardo A Oliveira, Wai W Cheung, Kalodiah G Toma, Robert H Mak
Loss of lean body mass is a relevant component of the cachexia, or protein energy wasting (PEW), syndrome. Reduced muscle mass seems to be the most solid criterion for the presence of cachexia/PEW in patients with chronic kidney disease (CKD), and those with greater muscle mass loss have a higher risk of death. Children with CKD have many risk factors for lean mass and muscle wasting, including poor appetite, inflammation, growth hormone resistance, and metabolic acidosis. Mortality risks in patients with CKD increases as body mass index (BMI) and weight decreases...
May 15, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28507171/first-in-man-demonstration-of-direct-endothelin-mediated-natriuresis-and-diuresis
#7
Robert W Hunter, Rebecca Moorhouse, Tariq E Farrah, Iain M MacIntyre, Takae Asai, Peter J Gallacher, Debbie Kerr, Vanessa Melville, Alicja Czopek, Emma E Morrison, Jess R Ivy, James W Dear, Matthew A Bailey, Jane Goddard, David J Webb, Neeraj Dhaun
Endothelin (ET) receptor antagonists are potentially novel therapeutic agents in chronic kidney disease and resistant hypertension, but their use is complicated by sodium and water retention. In animal studies, this side effect arises from ETB receptor blockade in the renal tubule. Previous attempts to determine whether this mechanism operates in humans have been confounded by the hemodynamic consequences of ET receptor stimulation/blockade. We aimed to determine the effects of ET signaling on salt transport in the human nephron by administering subpressor doses of the ET-1 precursor, big ET-1...
May 15, 2017: Hypertension
https://www.readbyqxmd.com/read/28506762/the-nuclear-phosphatase-scp4-regulates-foxo-transcription-factors-during-muscle-wasting-in-chronic-kidney-disease
#8
Xinyan Liu, Rizhen Yu, Lijing Sun, Giacomo Garibotto, Xia Lin, Yanlin Wang, Sandhya S Thomas, Rongshan Li, Zhaoyong Hu
Chronic kidney disease (CKD) and related inflammatory responses stimulate protein-energy wasting, a complication causing loss of muscle mass. Primarily, muscle wasting results from accelerated protein degradation via autophagic/lysosomal and proteasomal pathways, but mechanisms regulating these proteolysis pathways remain unclear. Since dephosphorylation of FoxOs regulates ubiquitin/proteasome protein metabolism, we tested whether a novel nuclear phosphatase, the small C-terminal domain phosphatase (SCP) 4, regulates FoxOs signaling and, in turn, muscle wasting...
May 12, 2017: Kidney International
https://www.readbyqxmd.com/read/28506549/impact-of-chronic-obstructive-pulmonary-disease-on-in-hospital-morbidity-and-mortality-in-patients-with-st-segment-elevation-myocardial-infarction-treated-by-primary-percutaneous-coronary-intervention
#9
Răzvan Constantin Șerban, Laszlo Hadadi, Ioana Șuș, Eva Katalin Lakatos, Zoltan Demjen, Alina Scridon
BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) presenting with ST-segment elevation myocardial infarction (STEMI) are less likely to beneficiate of primary percutaneous coronary intervention (pPCI), and have poorer prognosis. We aimed to evaluate the impact of COPD on the in-hospital outcomes of pPCI-treated STEMI patients. METHODS: Data were collected from 418 STEMI patients treated by pPCI. Inotropics and diuretics usage, cardiogenic shock, asystole, kidney dysfunction, and left ventricular ejection fraction were used as markers of hemodynamic complications...
May 11, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28503987/prevalence-of-chronic-kidney-disease-and-its-determinants-in-coronary-heart-disease-patients-in-24-european-countries-insights-from-the-euroaspire-iv-survey-of-the-european-society-of-cardiology
#10
Martin Wagner, Christoph Wanner, Kornelia Kotseva, David Wood, Dirk De Bacquer, Lars Rydén, Stefan Störk, Peter U Heuschmann
Aims Chronic kidney disease (CKD) is associated with the development and progression of coronary heart disease (CHD), in addition to classic cardiovascular risk factors. We analysed the prevalence of CKD in CHD patients from 24 European countries in the ambulatory setting and in a preceding hospital stay for CHD (index). Methods and results A total of 7998 EUROASPIRE IV participants (median 65 years of age, 76% male) attended a study visit 6-36 months after the index hospitalisation. CKD was classified according to stages of estimated glomerular filtration rate (eGFR) and albuminuria (urinary albumin/creatinine ratio)...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28503809/robot-assisted-laparoscopic-versus-open-partial-nephrectomy-in-patients-with-chronic-kidney-disease-a-propensity-score-matched-comparative-analysis-of-surgical-outcomes
#11
Toshio Takagi, Tsunenori Kondo, Hidekazu Tachibana, Junpei Iizuka, Kenji Omae, Hirohito Kobayashi, Kazuhiko Yoshida, Kazunari Tanabe
OBJECTIVES: To compare surgical outcomes between robot-assisted laparoscopic partial nephrectomy and open partial nephrectomy in patients with chronic kidney disease. METHODS: Of 550 patients who underwent partial nephrectomy between 2012 and 2015, 163 patients with T1-2 renal tumors who had an estimated glomerular filtration rate between 30 and 60 mL/min/1.73 m(2) , and underwent robot-assisted laparoscopic partial nephrectomy or open partial nephrectomy were retrospectively analyzed...
May 14, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28501426/attenuation-of-diabetic-nephropathy-by-sanziguben-granule-inhibiting-emt-through-nrf2-mediated-anti-oxidative-effects-in-streptozotocin-stz-induced-diabetic-rats
#12
Chenxue Zhang, Qian Li, Sisi Lai, Lei Yang, Guoqi Shi, Qing Wang, Zijie Luo, Ruizhi Zhao, Yang Yu
ETHNOPHARMACOLOGICAL RELEVANCE: Diabetic nephropathy (DN) is an acute and serious diabetic complication characterized by renal hypertrophy and renal fibrosis with the expansion of extracellular matrices. Diabetic nephropathy has become a major cause of end-stage kidney disease. Sanziguben Granule (SZGB) is a compound prescription which has been widely applied in clinical medicine for the prevention and treatment of diabetic nephropathy as well as for acute and chronic kidney injuries...
May 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28501301/osteocyte-dysfunction-and-renal-osteodystrophy-not-just-calcium-and-phosphorus-anymore
#13
Katherine Wesseling-Perry
In an important new cross-sectional analysis in this issue, Graciolli and colleagues present bone data from 148 adult patients across the spectrum of chronic kidney disease that confirm that disrupted osteocyte function and abnormal bone histology characterize all stages of chronic kidney disease and suggest that osteocytic Wnt signaling and osteocyte maturation may play a role in the pathogenesis of renal osteodystrophy. These concepts may alter how the skeletal, cardiovascular, and infectious complications of chronic kidney disease are managed...
June 2017: Kidney International
https://www.readbyqxmd.com/read/28494539/-current-status-and-perspectives-of-diagnosis-and-treatment-of-complications-related-to-liver-cirrhosis
#14
Y M Nan
Liver cirrhosis is the severe period of chronic liver diseases, especially decompensated liver cirrhosis and its complications, such as ascites, esophagogastric variceal bleeding, hepatic encephalopathy, acute kidney injury, and hepatocellular carcinoma, which greatly affect patients' quality of life and even threaten their lives. Early prevention and treatment of the causes of development and progression and pathogenic mechanism may slow down or reverse liver cirrhosis and its severe complications. Once the disease progresses to portal hypertension and related complications, it is very important to select preventive measures for acute exacerbation of different complications, as well as the methods and timing for treatment in acute stage, which may help to save patients' lives and improve their prognosis...
April 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28490305/long-term-risk-of-severe-retinopathy-in-childhood-onset-type-1-diabetes-a-data-linkage-study
#15
Mary White, Matthew A Sabin, Costan G Magnussen, Michele A O'Connell, Peter G Colman, Fergus Cameron
OBJECTIVES: To determine the relationship between glycaemic control trajectory and the long term risk of severe complications in people with type 1 diabetes mellitus, as well as the effects of paediatric and adult HbA1c levels. DESIGN, SETTING, PARTICIPANTS: Data linkage study of data for adults with childhood-onset type 1 diabetes (diagnosed during 1975-2010) who had transitioned from paediatric diabetes care at the Royal Children's Hospital (Melbourne) to adult diabetes care at the Royal Melbourne Hospital during 1992-2013...
May 15, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28488572/acute-hypocalcemia-following-kidney-transplantation-may-depend-on-the-type-of-remote-parathyroidectomy-a-retrospective-cohort-study%C3%A2
#16
Malorie Simons, Josef Bautista, Rachel Occhiogrosso, Lori Scott-Sheldon, Reginald Gohh
BACKGROUND: Secondary hyperparathyroidism is a common complication of chronic kidney disease. When medical management fails, parathyroidectomy (PTX) is a treatment option. The two most common types are subtotal PTX and total PTX with autotransplantation (AT). To date, there is no consensus as to which procedure is preferable, especially in patients who are candidates for future kidney transplantation. The aim of this study was to identify if the type of PTX is a risk factor for acute postrenal transplant (postRTX) hypocalcemia and a concern for problems with long-term calcium homeostasis...
May 10, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28487872/incidence-and-severity-of-nausea-and-vomiting-in-a-group-of-maintenance-hemodialysis-patients
#17
Mohammad Reza Asgari, Fatemeh Asghari, Ali Asghar Ghods, Raheb Ghorbani, Nahid Hoshmand Motlagh, Fatemeh Rahaei
Introduction: Chronic kidney disease (CKD) is a rising problem across the world, including Iran. Most of the patients will require hemodialysis for survival. Despite the great progress has been made in the hemodialysis equipment, but it is still associated with complications. Nausea and vomiting are common complication of during hemodialysis, which leads to unpleasant feeling in patients. Objectives: This study aimed to determine incidence and severity of nausea and vomiting in a group of maintenance hemodialysis patients...
2017: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/28487772/incidence-and-risk-factors-for-early-acute-kidney-injury-in-nonsurgical-patients-a-cohort-study
#18
Javier Enrique Cely, Elkin José Mendoza, Carlos Roberto Olivares, Oscar Julián Sepúlveda, Juan Sebastián Acosta, Rafael Andrés Barón, Juan José Diaztagle
Introduction. Detecting acute kidney injury (AKI) in the first days of hospitalization could prevent potentially fatal complications. However, epidemiological data are scarce, especially on nonsurgical patients. Objectives. To determine the incidence and risk factors associated with AKI within five days of hospitalization (EAKI). Methods. Prospective cohort of patients hospitalized in the Internal Medicine Department. Results. A total of 16% of 400 patients developed EAKI. The associated risk factors were prehospital treatment with nephrotoxic drugs (2...
2017: International Journal of Nephrology
https://www.readbyqxmd.com/read/28486895/severe-hyperkalaemia-complicating-parathyroidectomy-in-patients-with-end-stage-renal-disease
#19
M Pauling, J C Lee, J W Serpell, S Wilson
We evaluated the incidence of perioperative hyperkalaemia in end-stage renal disease (ESRD) patients undergoing parathyroidectomy and investigated possible contributors to this phenomenon. This was a retrospective cohort study looking at patients who had undergone parathyroidectomy for chronic kidney disease-associated mineral bone disease (CKD-MBD) at The Alfred Hospital, Melbourne, since 2001. Baseline demographics including age, gender, aetiology of renal failure and mode of renal replacement therapy as well as anaesthetic technique and duration of surgery were studied as possible contributors...
May 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28485203/expert-panel-recommendations-for-the-identification-and-management-of-hyperkalemia-and-role-of-patiromer-in-patients-with-chronic-kidney-disease-and-heart-failure
#20
Zubaid Rafique, Matthew R Weir, Macaulay Onuigbo, Bertram Pitt, Richard Lafayette, Javed Butler, Maria Lopes, Carolyn Farnum, W Frank Peacock
Virtual panel meetings were conducted among 7 physicians, all of whom are independent experts, including 3 nephrologists, 2 cardiologists, and 2 emergency medicine physicians (the panel). The panel met with the purpose of discussing the current treatment landscape, treatment challenges, economic impact, and gaps in care for patients with hyperkalemia that is associated with heart failure and chronic kidney disease. The stated goal of the panel discussion was to develop practical solutions in the identification and management of hyperkalemia in this patient population...
April 2017: Journal of Managed Care & Specialty Pharmacy
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