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cochlear dead region

Alicja N Malicka, Wayne J Wilson, Thomas Baer, Kevin J Munro, Richard J Baker, Deanna Miluzzi, Brian C J Moore
OBJECTIVES: Cochlear dead regions (DRs) are regions in the cochlea where the inner hair cells and/or neurons are not functioning. Adults with extensive high-frequency DRs have enhanced abilities in processing sounds with frequencies just below the edge frequency, fedge , of the DR. It was assessed whether the same is true for children. DESIGN: Performance was compared for children aged 8 to 13 years with: DRs (group DR), hearing impairment but without DRs (group NODR), and normal hearing (group NH)...
April 24, 2018: International Journal of Audiology
Soojin Kang, Jihwan Woo, Heesung Park, Carolyn J Brown, Sung Hwa Hong, Il Joon Moon
The goal of this study was to develop an objective and neurophysiologic method of identifying the presence of cochlear dead region (CDR) by combining acoustic change complex (ACC) responses with threshold-equalizing noise (TEN) test. The goal of the first study was to confirm whether ACC could be evoked with TEN stimuli and to also optimize the test conditions. The goal of the second study was to determine whether the TEN-ACC test is capable of detecting CDR(s). The ACC responses were successfully recorded from all study participants...
February 26, 2018: Scientific Reports
D Moualed, J Humphries, J D Ramsden
No abstract text is available yet for this article.
February 24, 2018: Clinical Otolaryngology
Ji Eun Choi, Jung Joo Lee, Won-Ho Chung, Yang-Sun Cho, Sung Hwa Hong, Il Joon Moon
OBJECTIVE: The aims of the present study were to investigate the prevalence of cochlear dead regions (DRs) in patients with sudden sensorineural hearing loss (SSNHL) and compare the hearing outcome according to the presence of DRs. STUDY DESIGN: Retrospective chart review. SETTING: Tertiary referral center. PATIENTS AND METHODS: The threshold-equalizing noise (HL) test was performed on a total of 112 ears diagnosed with SSNHL...
December 2016: Otology & Neurotology
Mohammad Ramadan Hassaan, Ola Abdallah Ibraheem, Dalia Helal Galhom
INTRODUCTION: Neural encoding of speech begins with the analysis of the signal as a whole broken down into its sinusoidal components in the cochlea, which has to be conserved up to the higher auditory centers. Some of these components target the dead regions of the cochlea causing little or no excitation. Measuring aided speech-evoked auditory brainstem response elicited by speech stimuli with different spectral maxima can give insight into the brainstem encoding of aided speech with spectral maxima at these dead regions...
July 2016: International Archives of Otorhinolaryngology
Lukas D Landegger, Demetri Psaltis, Konstantina M Stankovic
INTRODUCTION: As otology enters the field of gene therapy and human studies commence, the question arises whether audiograms - the current gold standard for the evaluation of hearing function - can consistently predict cellular damage within the human inner ear and thus should be used to define inclusion criteria for trials. Current assumptions rely on the analysis of small groups of human temporal bones post mortem or from psychophysical identification of cochlear "dead regions" in vivo, but a comprehensive study assessing the correlation between audiometric thresholds and cellular damage within the cochlea is lacking...
May 2016: Hearing Research
Anna Pepler, Kathryn Lewis, Kevin J Munro
OBJECTIVES: Cochlear dead regions (DR) are common in adult hearing-aid users, but are usually restricted to high frequencies. The aim was to determine the benefit of high-frequency amplification for ears with and without high-frequency DRs. DESIGN: Participants were fitted with the study hearing aid and tested under four conditions: unfiltered (NAL-NL2 prescription), and low-pass filtered at 1.5, 2, and 3 kHz. VCV stimuli were presented at 65 dB (A) in quiet and in 20-talker babble at a signal-to-babble ratio of 0 dB...
2016: International Journal of Audiology
Stefano Cosentino, Etienne Gaudrain, John M Deeks, Robert P Carlyon
OBJECTIVE: Electrically evoked compound action potentials (ECAPs) have been employed as a measure of neural activation evoked by cochlear implant (CI) stimulation. A forward-masking procedure is commonly used to reduce stimulus artefacts. This method estimates the joint neural activation produced by two electrodes-one acting as probe and the other as masker; as such, the measured ECAPs depend on the activation patterns produced by both. We describe an approach--termed panoramic ECAP ("PECAP")--that allows reconstruction of the underlying neural activation pattern of individual channels from ECAP amplitudes...
April 2016: IEEE Transactions on Bio-medical Engineering
Ho Yun Lee, Yu Mi Seo, Kyung Ae Kim, Yeon Shin Kang, Chin Saeng Cho
BACKGROUND AND OBJECTIVES: We aimed to make a preliminary assessment of the prevalence of cochlear dead regions (DRs) and the factors affecting the results of the threshold-equalizing noise (TEN) test in patients with hearing loss of various etiologies. SUBJECTS AND METHODS: Between May and July 2014, 109 patients (191 ears) with hearing loss who visited our outpatient clinic were prospectively enrolled. Pure tone audiometry and TEN (HL) test were performed for all the patients...
April 2015: Journal of Audiology & Otology
Mohsen Ahadi, Mina Milani, Saeed Malayeri
OBJECTIVES: To investigate the overall prevalence of cochlear dead regions in children with moderate to severe sensorineural hearing impairment. METHODS: Threshold-equalizing noise (or TEN) test was administered on thirty sensorineural hearing impaired children (8 girls, 22 boys), aged 5-14 years (mean±SD8.5±2.8). RESULTS: Classifying by subject, 76% tested positive for cochlear dead regions in one or both ears at least at one frequency...
August 2015: International Journal of Pediatric Otorhinolaryngology
Jong Ho Won, Gary L Jones, Il Joon Moon, Jay T Rubinstein
A cochlear implant (CI) electrode in a "cochlear dead region" will excite neighboring neural populations. In previous research that simulated such dead regions, stimulus information in the simulated dead region was either added to the immediately adjacent frequency regions or dropped entirely. There was little difference in speech perception ability between the two conditions. This may imply that there may be little benefit of ensuring that stimulus information on an electrode in a suspected cochlear dead region is transmitted...
April 2015: Journal of the Association for Research in Otolaryngology: JARO
Joshua Myers, Alicja N Malicka
OBJECTIVE: Psychophysical tuning curves (PTCs) have been used predominantly in laboratory settings to assess frequency selectivity in the auditory system. Recently, a fast-PTC procedure has been developed for diagnosis of cochlear dead regions. In this study the clinical feasibility of using fast PTCs in adults was investigated. Success rate (the number of successes per number of attempts) and repeatability were assessed. The range of the tip frequency (ftip) shift was established and different methods of ftip estimation compared...
December 2014: International Journal of Audiology
Ting Zhang, Michael F Dorman, Rene Gifford, Brian C J Moore
OBJECTIVE: The aims of this study were to (1) detect the presence and edge frequency (fe) of a cochlear dead region in the ear with residual acoustic hearing for bimodal cochlear implant users, and (2) determine whether amplification based on the presence or absence of a dead region would improve speech understanding and sound quality. DESIGN: Twenty-two listeners with a cochlear implant in one ear and residual acoustic hearing in the nonimplanted ear were tested...
July 2014: Ear and Hearing
Simon S Gao, Rosalie Wang, Patrick D Raphael, Yalda Moayedi, Andrew K Groves, Jian Zuo, Brian E Applegate, John S Oghalai
The tonotopic map of the mammalian cochlea is commonly thought to be determined by the passive mechanical properties of the basilar membrane. The other tissues and cells that make up the organ of Corti also have passive mechanical properties; however, their roles are less well understood. In addition, active forces produced by outer hair cells (OHCs) enhance the vibration of the basilar membrane, termed cochlear amplification. Here, we studied how these biomechanical components interact using optical coherence tomography, which permits vibratory measurements within tissue...
September 1, 2014: Journal of Neurophysiology
Anna Pepler, Kevin J Munro, Kathryn Lewis, Karolina Kluk
OBJECTIVE: To investigate repeatability, agreement, and clinical feasibility of the threshold equalizing noise (TEN) test and fast psychophysical tuning curve (PTC) measurements to detect off-frequency listening, an indicator of cochlear dead regions (DRs). DESIGN: The TEN-test was carried out from 0.5 to 4 kHz and fast PTCs were carried out at ≥ 2 frequencies. STUDY SAMPLE: The TEN-test was completed on 70 ears; fast PTCs were measured on 20 ears...
October 2014: International Journal of Audiology
Jiyue Chen, Ying Zhang
The cochlear dead regions are common exist in the case of moderate to profound sensorineural hearing loss. Patients with dead regions have demonstrated poor understanding of speech in noise and report less satisfaction with hearing aids than patients with no dead regions. Dead regions are assumed to occur if a hearing-impaired listener can be shown to be using off-place listening. A correctly diagnosed dead regions facilitates accurate and informed aural rehabilitation.
November 2013: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Anna Pepler, Kevin J Munro, Kathryn Lewis, Karolina Kluk
OBJECTIVES: The primary aim of this study was to identify the prevalence of dead regions (DRs) in new adult hearing aid referrals and existing adult hearing aid users. Secondary aims included determining the effect of hearing threshold levels and slope, age, and sex on the presence of DRs. DESIGN: Three hundred and seventy-six adults were recruited from a U.K. National Health Service audiology clinic. Three hundred and forty-three participants (674 ears) with a sensorineural hearing impairment were assessed for the presence of a DR at audiometric frequencies from 0...
May 2014: Ear and Hearing
Byanka Cagnacci Buzo, Renata Mota Mamede Carvallo
OBJECTIVE: Tinnitus is often related to auditory dysfunction. We hypothesised that, among individuals with normal auditory thresholds, the mechanism of frequency selectivity might differ between subjects with and without tinnitus. Our objective was to identify any differences between normal-hearing individuals with tinnitus and those without in terms of psychophysical tuning curves (PTCs) and threshold-equalising noise (TEN) test results. DESIGN: We determined PTCs and performed the TEN test...
January 2014: International Journal of Audiology
Farhait Kiani, Ushalline Yoganantha, Christine M Tan, Ray Meddis, Roland Schaette
The occurrence of subjective tinnitus has been linked to cochlear damage, as most tinnitus patients have impaired hearing, and animal studies have shown that the induction of hearing loss can lead to behavioural signs of tinnitus. In tinnitus patients, the pure-tone audiogram is the main source of information about cochlear damage, but hearing thresholds alone may not adequately reflect its magnitude. Etchelecou et al. (2011) reported that the majority of patients with acute tinnitus post impulse noise exposure showed off-frequency listening (OFL), which is not readily observed in pure-tone audiograms...
December 2013: Hearing Research
Zhangli Chen, Guangshu Hu
CHENFIT-AMP is a novel nonlinear strategy that combines the fitting (gain prescription) and amplification (gain implementation) procedures for cochlear hearing loss. The fitting part of CHENFIT-AMP prescribes gain for outer hair cell (OHC) and inner hair cell (IHC) loss, respectively. The gain for OHC loss varies with the cochlear gain decided by the value of OHC loss and the input level. The gain for IHC loss varies with the value of IHC loss only and will be limited to a constant if there is a "dead region...
November 2013: IEEE Transactions on Bio-medical Engineering
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