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Avian paramyxovirus

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https://www.readbyqxmd.com/read/29162154/pigeon-paramyxovirus-type-1-from-a-fatal-human-case-induces-pneumonia-in-experimentally-infected-cynomolgus-macaques-macaca-fascicularis
#1
Thijs Kuiken, Pascal Buijs, Peter van Run, Geert van Amerongen, Marion Koopmans, Bernadette van den Hoogen
Although avian paramyxovirus type 1 is known to cause mild transient conjunctivitis in human beings, there are two recent reports of fatal respiratory disease in immunocompromised human patients infected with the pigeon lineage of the virus (PPMV-1). In order to evaluate the potential of PPMV-1 to cause respiratory tract disease, we inoculated a PPMV-1 isolate (hPPMV-1/Netherlands/579/2003) from an immunocompromised human patient into three healthy cynomolgus macaques (Macaca fascicularis) and examined them by clinical, virological, and pathological assays...
November 21, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29098490/avian-viral-pathogens-in-swallows-zimbabwe-infectious-diseases-in-hirundinidae-a-risk-to-swallow
#2
A Caron, N Chiweshe, J Mundava, C Abolnik, A Capobianco Dondona, M Scacchia, N Gaidet
We sampled 417 swallows in a wetland ecosystem of Zimbabwe in February 2010 and October 2011. RT-PCR tests revealed circulation of avian paramyxovirus type I, avian influenza and West Nile disease viruses in these populations. We discuss the relevance of these findings in relation to what is known on the epidemiology of these viruses in these hosts and in relation to the host ecology. We conclude with recommendations to focus more research on Passeriformes in disease ecology and in particular on the hirundinidae family...
November 2, 2017: EcoHealth
https://www.readbyqxmd.com/read/29058150/next-generation-sequencing-of-five-new-avian-paramyxoviruses-8-isolates-from-kazakhstan-indicates-a-low-genetic-evolution-rate-over-four-decades
#3
Sasan Fereidouni, M Jenckel, A Seidalina, K Karamendin, M Beer, E Starick, S Asanova, E Kasymbekov, M Sayatov, A Kydyrmanov
Five avian paramyxoviruses of serotype 8 (APMV-8) were isolated during a study monitoring wild birds in Kazakhstan in 2013 and each was further characterized. The viruses were isolated from three White-fronted geese (Anser albifrons), one Whooper swan (Cygnus cygnus), and one Little stint (Calidris minuta). Before our study, only two complete APMV-8 sequences had been reported worldwide since their discovery in the USA and Japan in the 1970s. We report the complete genome sequences of the newly detected viruses and analyze the genetic evolution of the APMV-8 viruses over four decades...
October 22, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29038866/complete-genome-sequence-of-a-novel-avian-paramyxovirus-isolated-from-wild-birds-in-south-korea
#4
Jipseol Jeong, Youngsik Kim, Injung An, Seung-Jun Wang, Yongkwan Kim, Hyun-Jeong Lee, Kang-Seuk Choi, Se-Pyeong Im, Wongi Min, Jae-Ku Oem, Weonhwa Jheong
A novel avian paramyxovirus (APMV), Cheonsu1510, was isolated from wild bird feces in South Korea and serologically and genetically characterized. In hemagglutination inhibition tests, antiserum against Cheonsu1510 showed low reactivity with other APMVs and vice versa. The complete genome of Cheonsu1510 comprised 15,408 nucleotides, contained six open reading frames (3'-N-P-M-F-HN-L-5'), and showed low sequence identity to other APMVs (< 63%) and a unique genomic composition. Phylogenetic analysis revealed that Cheonsu1510 was related to but distinct from APMV-1, -9, and -15...
October 16, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28988534/biochemical-variations-in-cytolytic-activity-of-ortho-and-paramyxoviruses-in-human-lung-tumor-cell-culture
#5
O P Zhirnov
Human lung cancer cells (Calu-3 line) were studied for the development of apoptosis, necrosis, and autophagy in response to infection with ortho- and paramyxoviruses. Biochemical pathways underlying various mechanisms of cell death differed for different viruses. When infected with murine Sendai paramyxovirus, Calu-3 cells demonstrated typical necrotic features such as cell swelling (but not shrinkage), lack of chromatin DNA laddering, of caspase 3 and 8 activation, and of apoptotic cleavage of poly(ADP-ribose) polymerase (PARP) protein; an activation of antiapoptotic protein kinase Akt was also revealed...
September 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28982603/in-vitro-infectivity-of-oncolytic-newcastle-disease-virus-correlation-between-plaque-and-fluorescent-focus-assays
#6
Benjamin S Rush, Melissa L Coughlin, Gautam Sanyal
Newcastle Disease Virus (NDV) is an avian paramyxovirus that has no significant pathogenicity in humans. Cancer cells with impaired immune defense mechanisms are susceptible to infection and lysis by NDV. A recombinant construct of a lentogenic form of NDV (rNDV) containing an insertion of granulocyte macrophage colony stimulating factor (GMCSF) transgene was earlier reported and shown to have acceptably low avian pathogenicity as well as oncolytic potential. Reliable measurement of infectious titer is key to determining the effectiveness of virus preparations to infect and lyse cells...
January 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/28957006/recombinant-avian-paramyxovirus-serotypes-2-6-and-10-as-vaccine-vectors-for-highly-pathogenic-avian-influenza-in-chickens-with-antibodies-against-newcastle-disease-virus
#7
Ryota Tsunekuni, Hirokazu Hikono, Taichiro Tanikawa, Riho Kurata, Takaaki Nakaya, Takehiko Saito
Recombinant Newcastle disease virus (rNDV) expressing the hemagglutinin of highly pathogenic avian influenza virus (HPAIV HA) induces protective immunity against HPAIV in chickens. However, the efficacy of rNDV vectors is hampered when chickens are pre-immune to NDV, and most commercial chickens are routinely vaccinated against NDV. We recently showed that avian paramyxovirus serotypes 2, 6, and 10 (APMV-2, APMV-6, and APMV-10), which belong to the same genus as NDV, have low cross-reactivity with anti-NDV antisera...
September 2017: Avian Diseases
https://www.readbyqxmd.com/read/28950869/phylogenetic-assessment-reveals-continuous-evolution-and-circulation-of-pigeon-derived-virulent-avian-avulaviruses-1-in-eastern-europe-asia-and-africa
#8
Mahmoud Sabra, Kiril M Dimitrov, Iryna V Goraichuk, Abdul Wajid, Poonam Sharma, Dawn Williams-Coplin, Asma Basharat, Shafqat F Rehmani, Denys V Muzyka, Patti J Miller, Claudio L Afonso
BACKGROUND: The remarkable diversity and mobility of Newcastle disease viruses (NDV) includes virulent viruses of genotype VI. These viruses are often referred to as pigeon paramyxoviruses 1 because they are normally isolated and cause clinical disease in birds from the Columbidae family. Genotype VI viruses occasionally infect, and may also cause clinical disease in poultry. Thus, the evolution, current spread and detection of these viruses are relevant to avian health. RESULTS: Here, we describe the isolation and genomic characterization of six Egyptian (2015), four Pakistani (2015), and two Ukrainian (2007, 2013) recent pigeon-derived NDV isolates of sub-genotype VIg...
September 26, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28860100/a-polymerase-chain-reaction-assay-for-detection-of-virulent-and-attenuated-strains-of-duck-plague-virus
#9
Liji Xie, Zhixun Xie, Li Huang, Sheng Wang, Jiaoling Huang, Yanfang Zhang, Tingting Zeng, Sisi Luo
Sequence analysis of duck plague virus (DPV) revealed that there was a 528bp (B fragment) deletion within the UL2 gene of DPV attenuated vaccine strain in comparison with field virulent strains. The finding of gene deletion provides a potential differentiation test between DPV virulent strain and attenuated strain based on their UL2 gene sizes. Thus we developed a polymerase chain reaction (PCR) assay targeting to the DPV UL2 gene for simultaneous detection of DPV virulent strain and attenuated strain, 827bp for virulent strain and 299bp for attenuated strain...
August 30, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28685285/evaluation-of-the-replication-and-pathogenicity-of-a-variant-avian-paramyxovirus-serotype-6-in-mice
#10
Vuong Nghia Bui, Dai Quang Trinh, Lary N B Abao, Yuki Ozeki, Jonathan Runstadler, Kikuyasu Nakamura, Haruko Ogawa, Kunitoshi Imai
Avian paramyxoviruses (APMVs) have been evaluated for their potential use as vaccine vectors, sparking research efforts leading to a better understanding of APMVs' replication and pathogenicity. However, within APMV serotypes, significant genetic diversity exists, and the infectivity of variant strains in mammals has not been studied. We utilized a mouse model to evaluate the pathogenicity of a variant strain of APMV-6 (APMV-6/red-necked stint/Japan/8KS0813/2008) in comparison with the prototype APMV-6 strain (APMV-6/duck/Hong Kong/18/199/1977)...
July 6, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28603697/dispersal-and-transmission-of-avian-paramyxovirus-serotype-4-among-wild-birds-and-domestic-poultry
#11
Renfu Yin, Pingze Zhang, Xinxin Liu, Yanyu Chen, Zhi Tao, Lili Ai, Junjiao Li, Yingying Yang, Mingxin Li, Cong Xue, Jing Qian, Xueli Wang, Jing Chen, Yong Li, Yanping Xiong, Jun Zhang, Tobias Stoeger, Yuhai Bi, Jianjun Chen, Zhuang Ding
Avian paramyxovirus serotype 4 (APMV-4) is found sporadically in wild birds worldwide, and it is an economically important poultry pathogen. Despite the existence of several published strains, very little is known about the distribution, host species, and transmission of APMV-4 strains. To better understand the relationships among these factors, we conducted an APMV-4 surveillance of wild birds and domestic poultry in six provinces of China suspected of being intercontinental flyways and sites of interspecies transmission...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28595094/two-plasmid-system-to-increase-the-rescue-efficiency-of-paramyxoviruses-by-reverse-genetics-the-example-of-rescuing-newcastle-disease-virus
#12
Haijin Liu, Emmanuel Albina, Patricia Gil, Cécile Minet, Renata Servan de Almeida
Within paramyxoviruses, conventional reverse genetics require the transfection of a minimum of four plasmids: three to reconstruct the viral polymerase complex that replicates and expresses the virus genome delivered by a fourth plasmid. The successful transfection of four or more plasmids of different sizes into one cell and the subsequent generation of at least one viable and replicable viral particle is a rare event, which explains the low rescue efficiency, especially of low virulent viruses with reduced replication efficiency in cell lines...
September 2017: Virology
https://www.readbyqxmd.com/read/28592535/newcastle-disease-virus-establishes-persistent-infection-in-tumor-cells-in-vitro-contribution-of-the-cleavage-site-of-fusion-protein-and-second-sialic-acid-binding-site-of-hemagglutinin-neuraminidase
#13
Udaya S Rangaswamy, Weijia Wang, Xing Cheng, Patrick McTamney, Danielle Carroll, Hong Jin
Newcastle disease virus (NDV) is an oncolytic virus being developed for the treatment of cancer. Following infection of a human ovarian cancer cell line (OVCAR3) with a recombinant low-pathogenic NDV, persistent infection was established in a subset of tumor cells. Persistently infected (PI) cells exhibited resistance to superinfection with NDV and established an antiviral state, as demonstrated by upregulation of interferon and interferon-induced genes such as myxoma resistance gene 1 (Mx1) and retinoic acid-inducing gene-I (RIG-I)...
August 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28572332/complete-genome-sequences-of-four-avian-paramyxoviruses-of-serotype-10-isolated-from-rockhopper-penguins-on-the-falkland-islands
#14
Iryna V Goraichuk, Kiril M Dimitrov, Poonam Sharma, Patti J Miller, David E Swayne, David L Suarez, Claudio L Afonso
The first complete genome sequences of four avian paramyxovirus serotype 10 (APMV-10) isolates are described here. The viruses were isolated from rockhopper penguins on the Falkland Islands, sampled in 2007. All four genomes are 15,456 nucleotides in length, and phylogenetic analyses show them to be closely related.
June 1, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28533052/reverse-spillover-of-avian-viral-vaccine-strains-from-domesticated-poultry-to-wild-birds
#15
M A Rohaim, R F El Naggar, A M Helal, H A Hussein, Muhammad Munir
Transmission of viruses from the commercial poultry to wild birds is an emerging paradigm of livestock-wildlife interface. Here, we report the identification and isolation of vaccine strains of avian paramyxovirus serotype 1 (APMV1) and avian coronaviruses (ACoV) from different wild bird species across eight Egyptian governorates between January 2014 and December 2015. Surveillance of avian respiratory viruses in free-ranging wild birds (n=297) identified three species that harboured or excreted APMV1 and ACoVs...
May 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28529504/a-novel-avian-paramyxovirus-putative-serotype-15-isolated-from-wild-birds
#16
Hyun-Jeong Lee, Ji-Ye Kim, Youn-Jeong Lee, Eun-Kyung Lee, Byoung-Min Song, Hee-Soo Lee, Kang-Seuk Choi
In January 2014, a viral hemagglutinating agent named UPO216 was isolated from fecal droppings of wild birds at the UPO wetland in South Korea during an avian influenza surveillance program. Electron microscopy identified the UPO216 virus as an avian paramyxovirus (APMV). Pathogenicity tests and molecular pathotyping revealed that the virus was avirulent in chickens. The UPO216 virus was assigned to a serological group antigenically distinct from known serotypes of APMV (-1, -2, -3, -4, -6, -7, -8, and -9) by hemagglutination inhibition test, despite showing weak cross-reactivity with APMV-1 and APMV-9...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28522703/complete-genome-sequence-of-an-avian-paramyxovirus-type-4-strain-isolated-from-domestic-duck-at-a-live-bird-market-in-south-korea
#17
Erdene-Ochir Tseren-Ochir, Seong-Su Yuk, Jung-Hoon Kwon, Jin-Yong Noh, Woo-Tack Hong, Jei-Hyun Jeong, Sol Jeong, Yu-Jin Kim, Kyu-Jik Kim, Ji-Ho Lee, Jun-Beom Kim, Joong-Bok Lee, Seung-Yong Park, In-Soo Choi, Sang-Won Lee, Chang-Seon Song
We report here the first full-genome sequence of an avian paramyxovirus type 4 (APMV-4) strain isolated from a domestic mallard duck at a live bird market in South Korea. Phylogenetic analyses provide genetic information on a new genetic clade, APMV-4, isolated from a domestic duck and evidence of APMV-4 exchange between poultry and wild birds.
May 18, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28486490/novel-avian-paramyxovirus-apmv-15-isolated-from-a-migratory-bird-in-south-america
#18
Luciano Matsumiya Thomazelli, Jansen de Araújo, Thomas Fabrizio, David Walker, Dilmara Reischak, Tatiana Ometto, Carla Meneguin Barbosa, Maria Virginia Petry, Richard J Webby, Edison Luiz Durigon
A novel avian paramyxovirus (APMV) isolated from a migratory bird cloacal swab obtained during active surveillance in April 2012 in the Lagoa do Peixe National Park, Rio Grande do Sul state, South of Brazil was biologically and genetically characterized. The nucleotide sequence of the full viral genome was completed using a next-generation sequencing approach. The genome was 14,952 nucleotides (nt) long, with six genes (3'-NP-P-M-F-HN-L-5') encoding 7 different proteins, typical of APMV. The fusion (F) protein gene of isolate RS-1177 contained 1,707 nucleotides in a single open reading frame encoding a protein of 569 amino acids...
2017: PloS One
https://www.readbyqxmd.com/read/28473820/avian-paramyxovirus-type-3-as-a-vaccine-vector-identification-of-a-genome-location-for-high-level-expression-of-a-foreign-gene
#19
Asuka Yoshida, Siba K Samal
Avian paramyxovirus serotype 3 (APMV-3) causes infection in a wide variety of avian species, but it does not cause apparent diseases in chickens. On the contrary, APMV-1, also known as Newcastle disease virus (NDV), can cause severe disease in chickens. Currently, natural low virulence strains of NDV are used as live-attenuated vaccines throughout the world. NDV is also being evaluated as a vaccine vector against poultry pathogens. However, due to routine vaccination programs, chickens often possess pre-existing antibodies against NDV, which may cause the chickens to be less sensitive to recombinant NDV vaccines expressing antigens of other avian pathogens...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28451944/characterization-of-colombian-serotype-1-avian-paramyxoviruses-2008-2010
#20
Y Berhane, T Hisanaga, W Xu, N A Mosos Campos, H Kehler, C P Calderón Parra, J Pasick
Newcastle disease (ND) still remains one of the most important diseases affecting domestic poultry in Colombia. Here, for the first time, we report on the molecular characterization of 12 virulent and 12 avirulent or lentogenic avian paramyxovirus type 1 (APMV-1) strains that were isolated from commercial, backyard, and game poultry in Colombia from 2008 to 2010. The 12 virulent isolates had a fusion (F) protein cleavage site with basic amino acids at positions 113, 115, and 116 and a phenylalanine at position 117 ((112)RRQKR*F(117)), characteristic of virulent strains...
August 2017: Virus Genes
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