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Avian paramyxovirus

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https://www.readbyqxmd.com/read/29758054/effect-of-fusion-protein-cleavage-site-sequence-on-generation-of-a-genotype-vii-newcastle-disease-virus-vaccine
#1
Vinoth K Manoharan, Berin P Varghese, Anandan Paldurai, Siba K Samal
Newcastle disease (ND) causes severe economic loss to poultry industry worldwide. Frequent outbreaks of ND in commercial chickens vaccinated with live vaccines suggest a need to develop improved vaccines that are genetically matched against circulating Newcastle disease virus (NDV) strains. In this study, the fusion protein cleavage site (FPCS) sequence of NDV strain Banjarmasin/010 (Banj), a genotype VII NDV, was individually modified using primer mutagenesis to those of avian paramyxovirus (APMV) serotypes 2, 7 and 8 and compared with the recombinant Banjarmasin (rBanj) with avirulent NDV LaSota cleavage site (rBanj-LaSota)...
2018: PloS One
https://www.readbyqxmd.com/read/29601871/molecular-characterization-and-genetic-diversity-of-avian-paramyxovirus-type-4-isolated-in-south-korea-from-2013-to-2017
#2
Erdene-Ochir Tseren-Ochir, Jung-Hoon Kwon, Jin-Yong Noh, Jei-Hyun Jeong, Sol Jeong, Kyu-Jik Kim, Ji-Ho Lee, Jun-Beom Kim, Yu-Jin Kim, Sun-Hak Lee, Jun-Young Kim, Chang-Seon Song
In recent years, avian paramyxovirus type 4 (APMV-4) frequently isolated from wild and domestic bird populations particularly waterfowls worldwide. However, molecular characteristics and genetic diversity of APMV-4 are uncertain, owing to the limited availability of sequence information. A total of 11 APMV-4 strains from 9850 fecal, swab, and environmental samples were isolated during the surveillance program in wintering seasons of 2013-2017 in South Korea. We performed genetic characterization and phylogenetic analysis to investigate the genetic diversity and relatedness between isolates from the region...
March 27, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29601508/deep-sequencing-based-transcriptome-profiling-reveals-avian-interferon-stimulated-genes-and-provides-comprehensive-insight-into-newcastle-disease-virus-induced-host-responses
#3
Weiwei Liu, Xusheng Qiu, Cuiping Song, Yingjie Sun, Chunchun Meng, Ying Liao, Lei Tan, Zhuang Ding, Xiufan Liu, Chan Ding
Newcastle disease virus (NDV) is an avian paramyxovirus that causes significant economic losses to the poultry industry worldwide, with variations in NDV pathogenicity due to the differences in virulence between strains. However, there is limited knowledge regarding the avian innate immune response to NDV infection. In this study, transcriptional profiles were obtained from chick embryo fibroblasts (CEFs) that were infected with the highly virulent NDV Herts/33 strain or the nonvirulent LaSota strain using RNA-seq...
March 30, 2018: Viruses
https://www.readbyqxmd.com/read/29570719/avian-viral-surveillance-in-victoria-australia-and-detection-of-two-novel-avian-herpesviruses
#4
Jemima Amery-Gale, Carol A Hartley, Paola K Vaz, Marc S Marenda, Jane Owens, Paul A Eden, Joanne M Devlin
Viruses in avian hosts can pose threats to avian health and some have zoonotic potential. Hospitals that provide veterinary care for avian patients may serve as a site of exposure of other birds and human staff in the facility to these viruses. They can also provide a useful location to collect samples from avian patients in order to examine the viruses present in wild birds. This study aimed to investigate viruses of biosecurity and/or zoonotic significance in Australian birds by screening samples collected from 409 birds presented to the Australian Wildlife Health Centre at Zoos Victoria's Healesville Sanctuary for veterinary care between December 2014 and December 2015...
2018: PloS One
https://www.readbyqxmd.com/read/29556820/genetic-diversity-of-avian-avulavirus-1-newcastle-disease-virus-genotypes-vig-and-viib-circulating-in-wild-birds-in-kazakhstan
#5
Mukhit B Orynbayev, Sasan Fereidouni, Abylay R Sansyzbai, Bakhytkul A Seidakhmetova, Vitaliy M Strochkov, Askar M Nametov, Sandugash O Sadikaliyeva, Asel Nurgazieva, Kaissar K Tabynov, Nurkuysa M Rametov, Kulyaisan T Sultankulova
In order to improve current understanding of the molecular epidemiology of avian avulavirus 1 (AAvV-1, formerly avian paramyxovirus 1) in wild birds in Kazakhstan, 860 cloacal swab samples were evaluated. Samples were collected from 37 families of wild birds in nine different regions in the years 2011 and 2014. Overall, 54 positive samples (4.2%) were detected from 17 different families of wild birds, and 16 AAvV-1 isolates were characterized. Three of the isolates contained the fusion protein cleavage site motif RRQKR, and 13 contained KRQKR, which is typical for pathogenic strains of AAvV-1...
March 20, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29517403/genetic-diversity-of-avian-paramyxovirus-type-6-isolated-from-wild-ducks-in-the-republic-of-korea
#6
Kang-Seuk Choi, Ji-Ye Kim, Hyun-Jeong Lee, Min-Jun Jang, Hyuk-Moo Kwon, Haan-Woo Sung
Eleven avian paramyxovirus type 6 (APMV-6) isolates from Eurasian Wigeon ( n=5; Anas penelope), Mallards ( n=2; Anas platyrhynchos), and unknown species of wild ducks ( n=4) from Korea were analyzed based on the nucleotide (nt) and deduced amino acid (aa) sequences of the fusion (F) gene. Fecal samples were collected in 2010-2014. Genotypes were assigned based on phylogenetic analyses. Our results revealed that APMV-6 could be classified into at least two distinct genotypes, G1 and G2. The open reading frame (ORF) of the G1 genotype was 1,668 nt in length, and the putative F0 cleavage site sequence was 113 PAPEPRL119 ...
March 8, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29373675/zoonotic-infection-with-pigeon-paramyxovirus-type-1-linked-to-fatal-pneumonia
#7
Thijs Kuiken, Mya Breitbart, Martin Beer, Christian Grund, Dirk Höper, Bernadette van den Hoogen, Jean-Louis H Kerkhoffs, Aloys C M Kroes, Karyna Rosario, Peter van Run, Matthias Schwarz, Sanela Svraka, Jens Teifke, Marion Koopmans
The characteristics and risk factors of pigeon paramyxovirus type 1 (PPMV-1) infection in humans are poorly known. We performed virological, pathological and epidemiological analyses of a Dutch case, and compared the results with those of a US case. Both infections occurred in transplant patients under immunosuppressive therapy and caused fatal respiratory failure. Both virus isolates clustered with avian paramyxovirus type 1 (APMV-1) genotype VIb/1, which has pigeons and doves as reservoir. Experimentally inoculated pigeons became infected and transmitted the virus to naïve pigeons...
January 24, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29325564/engineered-recombinant-protein-products-of-the-avian-paramyxovirus-type-1-nucleocapsid-and-phosphoprotein-genes-for-serological-diagnosis
#8
Na Zhao, Christian Grund, Martin Beer, Timm C Harder
BACKGROUND: Virulent Newcastle disease virus (NDV, avian Avulavirus-1, APMV-1) induces a highly contagious and lethal systemic disease in gallinaceous poultry. APMV-1 antibody detection is used for surveillance and to control vaccination, but is hampered by cross-reactivity to other subtypes of avian Avulaviruses. Data are lacking concerning the applicability of NDV V proteins as differential diagnostic marker to distinguish vaccinated from virus-infected birds (DIVA strategy). METHODS: Full length and C-terminally truncated nucleocapsid (NP) protein, and the unique C-terminal regions of the phospho- (P) and V proteins of the NDV LaSota strain were bacterially expressed as fusion proteins with the multimerization domain of the human C4 binding protein, and used as diagnostic antigens in indirect ELISA...
January 11, 2018: Virology Journal
https://www.readbyqxmd.com/read/29286260/molecular-characterization-of-avian-paramyxovirus-types-4-and-8-isolated-from-wild-migratory-waterfowl-in-mongolia
#9
Erdene-Ochir Tseren-Ochir, Seong-Su Yuk, Bodisaikhan Khishgee, Jung-Hoon Kwon, Jin-Yong Noh, Woo-Tack Hong, Jei-Hyun Jeong, Gyeong-Bin Gwon, Sol Jeong, Yu-Jin Kim, Jun-Beom Kim, Ji-Ho Lee, Kyu-Jik Kim, Batchuluun Damdinjav, Chang-Seon Song
Avian paramyxoviruses (APMVs) constitute some of the most globally prevalent avian viruses and are frequently isolated from wild migratory bird species. Using 1,907 fresh fecal samples collected during the 2012 avian influenza surveillance program, we identified two serotypes of APMV: APMV-4 ( n=10) and APMV-8 ( n=1). Sequences for these isolates phylogenetically clustered with Asian APMV-4 and APMV-8 recently isolated from wild birds in Korea, Japan, China, and Kazakhstan. Analysis by DNA barcoding indicated that the Mongolian APMV-4 and APMV-8 strains were isolated from Anseriformes species including Mallards ( Anas platyrhynchos) and Whooper Swans ( Cygnus cygnus)...
December 29, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29284037/novel-avian-paramyxovirus-isolated-from-gulls-in-caspian-seashore-in-kazakhstan
#10
Kobey Karamendin, Aidyn Kydyrmanov, Yermukhammet Kasymbekov, Saule Asanova, Klara Daulbayeva, Aigerim Seidalina, Elizaveta Khan, Sally M Harrison, Ian M Carr, Simon J Goodman, Alibek Moldakozhayev, Marat Sayatov
Three isolates APMV/gull/Kazakhstan/5976/2014, APMV/gull/Kazakhstan/ 5977/2014 and APMV/gull/Kazakhstan/5979/2014, were obtained from independent samples during annual surveillance for avian influenza and paramyxoviruses in wild birds from the Caspian Sea coast in Western Kazakhstan, and were initially identified as putative paramyxoviruses on the basis of electron microscopy. Hemagglutination Inhibition Assays with antisera to nine known APMV serotypes (APMV1-9) indicated no relation to any of them. Next generation sequencing of whole genome sequences indicated the three isolates were genetically identical, and had a nucleotide structure typical for all APMVs, consisting of six genes 3'-NP-P-M-F-HN-L-5'...
2017: PloS One
https://www.readbyqxmd.com/read/29162154/pigeon-paramyxovirus-type-1-from-a-fatal-human-case-induces-pneumonia-in-experimentally-infected-cynomolgus-macaques-macaca-fascicularis
#11
Thijs Kuiken, Pascal Buijs, Peter van Run, Geert van Amerongen, Marion Koopmans, Bernadette van den Hoogen
Although avian paramyxovirus type 1 is known to cause mild transient conjunctivitis in human beings, there are two recent reports of fatal respiratory disease in immunocompromised human patients infected with the pigeon lineage of the virus (PPMV-1). In order to evaluate the potential of PPMV-1 to cause respiratory tract disease, we inoculated a PPMV-1 isolate (hPPMV-1/Netherlands/579/2003) from an immunocompromised human patient into three healthy cynomolgus macaques (Macaca fascicularis) and examined them by clinical, virological, and pathological assays...
November 21, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29098490/avian-viral-pathogens-in-swallows-zimbabwe-infectious-diseases-in-hirundinidae-a-risk-to-swallow
#12
A Caron, N Chiweshe, J Mundava, C Abolnik, A Capobianco Dondona, M Scacchia, N Gaidet
We sampled 417 swallows in a wetland ecosystem of Zimbabwe in February 2010 and October 2011. RT-PCR tests revealed circulation of avian paramyxovirus type I, avian influenza and West Nile disease viruses in these populations. We discuss the relevance of these findings in relation to what is known on the epidemiology of these viruses in these hosts and in relation to the host ecology. We conclude with recommendations to focus more research on Passeriformes in disease ecology and in particular on the hirundinidae family...
November 2, 2017: EcoHealth
https://www.readbyqxmd.com/read/29058150/next-generation-sequencing-of-five-new-avian-paramyxoviruses-8-isolates-from-kazakhstan-indicates-a-low-genetic-evolution-rate-over-four-decades
#13
Sasan Fereidouni, M Jenckel, A Seidalina, K Karamendin, M Beer, E Starick, S Asanova, E Kasymbekov, M Sayatov, A Kydyrmanov
Five avian paramyxoviruses of serotype 8 (APMV-8) were isolated during a study monitoring wild birds in Kazakhstan in 2013 and each was further characterized. The viruses were isolated from three White-fronted geese (Anser albifrons), one Whooper swan (Cygnus cygnus), and one Little stint (Calidris minuta). Before our study, only two complete APMV-8 sequences had been reported worldwide since their discovery in the USA and Japan in the 1970s. We report the complete genome sequences of the newly detected viruses and analyze the genetic evolution of the APMV-8 viruses over four decades...
February 2018: Archives of Virology
https://www.readbyqxmd.com/read/29038866/complete-genome-sequence-of-a-novel-avian-paramyxovirus-isolated-from-wild-birds-in-south-korea
#14
Jipseol Jeong, Youngsik Kim, Injung An, Seung-Jun Wang, Yongkwan Kim, Hyun-Jeong Lee, Kang-Seuk Choi, Se-Pyeong Im, Wongi Min, Jae-Ku Oem, Weonhwa Jheong
A novel avian paramyxovirus (APMV), Cheonsu1510, was isolated from wild bird feces in South Korea and serologically and genetically characterized. In hemagglutination inhibition tests, antiserum against Cheonsu1510 showed low reactivity with other APMVs and vice versa. The complete genome of Cheonsu1510 comprised 15,408 nucleotides, contained six open reading frames (3'-N-P-M-F-HN-L-5'), and showed low sequence identity to other APMVs (< 63%) and a unique genomic composition. Phylogenetic analysis revealed that Cheonsu1510 was related to but distinct from APMV-1, -9, and -15...
January 2018: Archives of Virology
https://www.readbyqxmd.com/read/28988534/biochemical-variations-in-cytolytic-activity-of-ortho-and-paramyxoviruses-in-human-lung-tumor-cell-culture
#15
O P Zhirnov
Human lung cancer cells (Calu-3 line) were studied for the development of apoptosis, necrosis, and autophagy in response to infection with ortho- and paramyxoviruses. Biochemical pathways underlying various mechanisms of cell death differed for different viruses. When infected with murine Sendai paramyxovirus, Calu-3 cells demonstrated typical necrotic features such as cell swelling (but not shrinkage), lack of chromatin DNA laddering, of caspase 3 and 8 activation, and of apoptotic cleavage of poly(ADP-ribose) polymerase (PARP) protein; an activation of antiapoptotic protein kinase Akt was also revealed...
September 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28982603/in-vitro-infectivity-of-oncolytic-newcastle-disease-virus-correlation-between-plaque-and-fluorescent-focus-assays
#16
COMPARATIVE STUDY
Benjamin S Rush, Melissa L Coughlin, Gautam Sanyal
Newcastle Disease Virus (NDV) is an avian paramyxovirus that has no significant pathogenicity in humans. Cancer cells with impaired immune defense mechanisms are susceptible to infection and lysis by NDV. A recombinant construct of a lentogenic form of NDV (rNDV) containing an insertion of granulocyte macrophage colony stimulating factor (GMCSF) transgene was earlier reported and shown to have acceptably low avian pathogenicity as well as oncolytic potential. Reliable measurement of infectious titer is key to determining the effectiveness of virus preparations to infect and lyse cells...
January 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/28957006/recombinant-avian-paramyxovirus-serotypes-2-6-and-10-as-vaccine-vectors-for-highly-pathogenic-avian-influenza-in-chickens-with-antibodies-against-newcastle-disease-virus
#17
Ryota Tsunekuni, Hirokazu Hikono, Taichiro Tanikawa, Riho Kurata, Takaaki Nakaya, Takehiko Saito
Recombinant Newcastle disease virus (rNDV) expressing the hemagglutinin of highly pathogenic avian influenza virus (HPAIV HA) induces protective immunity against HPAIV in chickens. However, the efficacy of rNDV vectors is hampered when chickens are pre-immune to NDV, and most commercial chickens are routinely vaccinated against NDV. We recently showed that avian paramyxovirus serotypes 2, 6, and 10 (APMV-2, APMV-6, and APMV-10), which belong to the same genus as NDV, have low cross-reactivity with anti-NDV antisera...
September 2017: Avian Diseases
https://www.readbyqxmd.com/read/28950869/phylogenetic-assessment-reveals-continuous-evolution-and-circulation-of-pigeon-derived-virulent-avian-avulaviruses-1-in-eastern-europe-asia-and-africa
#18
Mahmoud Sabra, Kiril M Dimitrov, Iryna V Goraichuk, Abdul Wajid, Poonam Sharma, Dawn Williams-Coplin, Asma Basharat, Shafqat F Rehmani, Denys V Muzyka, Patti J Miller, Claudio L Afonso
BACKGROUND: The remarkable diversity and mobility of Newcastle disease viruses (NDV) includes virulent viruses of genotype VI. These viruses are often referred to as pigeon paramyxoviruses 1 because they are normally isolated and cause clinical disease in birds from the Columbidae family. Genotype VI viruses occasionally infect, and may also cause clinical disease in poultry. Thus, the evolution, current spread and detection of these viruses are relevant to avian health. RESULTS: Here, we describe the isolation and genomic characterization of six Egyptian (2015), four Pakistani (2015), and two Ukrainian (2007, 2013) recent pigeon-derived NDV isolates of sub-genotype VIg...
September 26, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28860100/a-polymerase-chain-reaction-assay-for-detection-of-virulent-and-attenuated-strains-of-duck-plague-virus
#19
Liji Xie, Zhixun Xie, Li Huang, Sheng Wang, Jiaoling Huang, Yanfang Zhang, Tingting Zeng, Sisi Luo
Sequence analysis of duck plague virus (DPV) revealed that there was a 528bp (B fragment) deletion within the UL2 gene of DPV attenuated vaccine strain in comparison with field virulent strains. The finding of gene deletion provides a potential differentiation test between DPV virulent strain and attenuated strain based on their UL2 gene sizes. Thus we developed a polymerase chain reaction (PCR) assay targeting to the DPV UL2 gene for simultaneous detection of DPV virulent strain and attenuated strain, 827bp for virulent strain and 299bp for attenuated strain...
August 30, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28685285/evaluation-of-the-replication-and-pathogenicity-of-a-variant-avian-paramyxovirus-serotype-6-in-mice
#20
Vuong Nghia Bui, Dai Quang Trinh, Lary N B Abao, Yuki Ozeki, Jonathan Runstadler, Kikuyasu Nakamura, Haruko Ogawa, Kunitoshi Imai
Avian paramyxoviruses (APMVs) have been evaluated for their potential use as vaccine vectors, sparking research efforts leading to a better understanding of APMVs' replication and pathogenicity. However, within APMV serotypes, significant genetic diversity exists, and the infectivity of variant strains in mammals has not been studied. We utilized a mouse model to evaluate the pathogenicity of a variant strain of APMV-6 (APMV-6/red-necked stint/Japan/8KS0813/2008) in comparison with the prototype APMV-6 strain (APMV-6/duck/Hong Kong/18/199/1977)...
October 2017: Archives of Virology
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