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Sputum cytology

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https://www.readbyqxmd.com/read/29874900/malignant-pleural-effusion-from-metastatic-prostate-cancer-a-case-report-with-unusual-cytologic-findings
#1
Jinyoung Jeon, Tae-Jung Kim, Hong Sik Park, Kyo-Young Lee
We present a case of 55-year-old man who complained of dyspnea and sputum for a month. He was an ex-smoker having a history of prostate cancer and pulmonary tuberculosis. Chest radiographs revealed small to moderate amount of bilateral pleural effusions. Pigtail catheters were inserted and drainage was performed. The pleural fluid contained malignant cells, arranged in large clusters and tightly cohesive groups. These cytologic findings could not with certainty be ascribed to prostate cancer. We performed immunocytochemical (ICH) panel studies to determine the origin of cancer metastasis...
June 7, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29870159/can-inflammatory-markers-in-induced-sputum-be-used-to-detect-phenotypes-and-endotypes-of-pediatric-severe-therapy-resistant-asthma
#2
Miriam C N Eller, Karina P Vergani, Beatriz M Saraiva-Romanholo, Leila Antonangelo, Claudio Leone, Joaquim C Rodrigues
BACKGROUND: The phenotypes and endotypes of severe therapy-resistant asthma (STRA) have not been fully elucidated in children. The aim of the present study was to investigate inflammatory markers in the induced sputum of children with STRA and to compare them with those present in a group of children who achieved control. METHODS: A prospective cohort of children (6-18 years of age) diagnosed with severe asthma (GINA criteria) who had undergone treatment for at least 6 months was comprehensively followed for 3 months...
June 5, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29796119/an-epigenetic-classifier-for-early-stage-lung-cancer
#3
Yun Su, Hong Bin Fang, Feng Jiang
Background: Methylated genes detected in sputum are promise biomarkers for lung cancer. Yet the current PCR technologies for quantification of DNA methylation and diagnostic value of the sputum biomarkers are not sufficient to be used for lung cancer early detection. The emerging droplet digital PCR (ddPCR) is a straightforward means for precise, direct, and absolute quantification of nucleic acids. Here, we investigate whether ddPCR can sensitively and robustly quantify DNA methylation in sputum for more precise diagnosis of lung cancer...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29755068/-tuberculous-pleurisy-diagnosed-by-thoracoscopic-lung-biopsy
#4
Jun Yamamoto, Miho Nishiura, Takanori Ohata, Ho Namkoong, Shinji Sakaguchi, Fumitake Saito, Hideki Yuki
A 44-year-old woman was referred to our hospital with pleural effusion and unknown fever. Mycobacterium tuberculosis was not detected by culture of pleural effusion and sputum and gastric fluid. Pleural fluid was serous and exudative, and cytological examination showed no malignant cells. Computed tomography revealed a little pleural thickening of the right middle lobe and massive pleural effusion. As acute pleurisy was suspected based on the findings of imaging studies, thoracoscopy was performed under general anesthesia...
March 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29686791/lung-consolidation-as-a-rare-presentation-of-lymphoplasmacytic-lymphoma-with-extramedullary-waldenstr%C3%A3-m-s-macroglobulinemia
#5
Omar Abdulfattah, Ebad Ur Rahman, Bikash Bhattarai, Sumit Dahal, Zainab Alnafoosi, David Trauber, Danilo Enriquez, Frances Schmidt
Objectives : Lymphoplasmacytic lymphoma (LPL) is a mature B cell lymphoma that usually involves the bone marrow, spleen and lymph nodes. Extramedullary involvement, including the lung, is rarely reported. Case description : A 73-year-old female initially presented to our hospital complaining of productive cough of white-colour sputum for three weeks duration. She reported unintentional weight loss of ten pounds over the last five months. There was no history of haemoptysis, fever, night sweats, chills, recent infections or hospitalization...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29652319/-modern-approaches-to-the-diagnosis-of-precancerous-pathology-and-early-lung-cancer
#6
A A Strunina, D V Sokolov, V V Sokolov, N N Volchenko, S V Kashin
AIM: To assess the possibilities of modern diagnostic techniques to diagnose precancerous pathology and early central lung cancer. MATERIAL AND METHODS: Analysis of Russian and foreign publications for precancerous pathology and early lung cancer, results and comparison of various diagnostic techniques. RESULTS: Central lung cancer has a stepwise development with transformation of normal bronchial epithelium to hyperplastic followed by focal metaplasia, dysplasia, cancer in situ (CIS) and microinvasive cancer...
2018: Khirurgiia
https://www.readbyqxmd.com/read/29497290/safety-and-effectiveness-of-the-high-frequency-chest-wall-oscillation-vs-intrapulmonary-percussive-ventilation-in-patients-with-severe-copd
#7
Antonello Nicolini, Bruna Grecchi, Maura Ferrari-Bravo, Cornelius Barlascini
Purpose: Chest physiotherapy is an important tool in the treatment of COPD. Intrapulmonary percussive ventilation (IPV) and high-frequency chest wall oscillation (HFCWO) are techniques designed to create a global percussion of the lung which removes secretions and probably clears the peripheral bronchial tree. We tested the hypothesis that adding IPV or HFCWO to the best pharmacological therapy (PT) may provide additional clinical benefit over chest physiotherapy in patients with severe COPD...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29453637/cough-hypersensitivity-in-patients-with-obstructive-sleep-apnea-hypopnea-syndrome
#8
Cuiqin Shi, Siwei Liang, Xianghuai Xu, Qiang Chen, Lan Wang, Li Yu, Hanjing Lv, Zhongmin Qiu
PURPOSE: The purpose of this study was to investigate cough hypersensitivity and its potential mechanisms in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). METHODS: Fifteen OSAHS patients, 12 simple snoring patients, and 15 healthy volunteers received cough sensitivity test and induced sputum cytology. Cough thresholds C2 and C5 (the minimum of capsaicin inducing ≥ 2 and ≥ 5 coughs, respectively), total cell count, cell differentials and the levels of bradykinin, histamine, prostaglandin E2 , substance P, calcitonin gene-related peptide, pepsin, and interleukin-2 in the induced sputum detected by enzyme-linked immunosorbent assay were compared...
February 16, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29436153/advanced-imaging-technology-applications-in-cytology
#9
Liron Pantanowitz, Frederic Preffer, David C Wilbur
Novel techniques have been developed to image cells at cellular and subcellular levels. They allow images to be analyzed with ultra-high resolution, in 2D and/or 3D. Several of these tools have been tested on cytology specimens demonstrating emerging applications that are likely to change the field of cytopathology. This review covers several of these advanced imaging methods. The use of optical coherence tomography to perform optical biopsies during endoscopic ultrasound procedures or visualize cells within effusion samples is discussed...
February 12, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29417838/lung-cancer-a-brief-review-of-epidemiology-and-screening
#10
Cláudia Gouvinhas, Ramon Andrade De Mello, Daniela Oliveira, José Manuel Castro-Lopes, Pedro Castelo-Branco, Ricardo Sales Dos Santos, Venceslau Hespanhol, Daniel Humberto Pozza
The global burden of lung cancer has been increasing over the past years, and is still a major threat to public health worldwide, leading to disabilities and premature mortality. Despite multifactorial cause, smoking remains as the major etiological factor, followed by occupational exposure to carcinogens, genetic predisposition and other concomitant diseases. In order to reduce the individual and social burden due to the direct and indirect costs related to the lung cancer treatment, accurate methods of screening are needed...
March 2018: Future Oncology
https://www.readbyqxmd.com/read/29403171/sputum-cytology-curschmann-s-spiral-or-parasite-larva
#11
Rafael Martínez-Girón, Cristina Martínez-Torre
No abstract text is available yet for this article.
January 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29395563/-bacteriology-of-acute-exacerbations-of-chronic-obstructive-pulmonary-disease-in-tunisia
#12
S Messous, M H Grissa, K Beltaief, R Boukef, S Nouira, M Mastouri
INTRODUCTION: The role of bacteria, including atypical organisms, in acute exacerbations of chronic obstructive pulmonary disease (AECOPD) has been assessed in various ways in Tunisia. METHODS: This was a descriptive and analytical study of patients with a mean age of 68.3±10.5 years hospitalized for AECOPD. Bacteriological examination included a cytological sputum exam and serology for atypical organisms including Mycoplasma pneumoniae, Coxiella burnetii, Chlamydophila pneumoniae and Legionella pneumophila using standard techniques...
January 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29368894/-airway-metaplasia-related-to-smoking-and-environmental-pollution-through-sputum
#13
Floribel Ferman-Cano, Fernando Padilla-Santamaría, Luis Moreno-Venegas, Carlos Alejandro Torner-Aguilar, Miguel Angel Molina-Medina
BACKGROUND: Both environmental pollution and smoking affect the respiratory epithelium, causing cellular adaptation changes. Therefore, this work explores the presence of metaplasia in smokers compared with non-smokers from Mexico City. METHODS: A prospective cohort study was performed. The sample was performed through a home interview covering the five Mexico City zones delimited to the study and monitoring of air quality. We searched metaplastic cells and inflammation in sputum cytology stained with Papanicolaou technique, and we assessed the air quality in Mexico City...
January 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29363060/inflammation-oxidative-stress-and-higher-expression-levels-of-nrf2-and-nqo1-proteins-in-the-airways-of-women-chronically-exposed-to-biomass-fuel-smoke
#14
Nandan Kumar Mondal, Hirak Saha, Bidisha Mukherjee, Neetu Tyagi, Manas Ranjan Ray
The study was carried out to examine whether chronic exposure to smoke during daily household cooking with biomass fuel (BMF) elicits changes in airway cytology and expressions of Nrf2 (nuclear factor erythroid 2 [NF-E2]-related factor 2 [Nrf2]), Keap1 (Kelch-like erythroid-cell-derived protein with CNC homology [ECH]-associated protein 1), and NQO1 (NAD(P)H:quinone oxidoreductase 1) proteins in the airways. For this, 282 BMF-using women (median age 34 year) and 236 age-matched women who cooked with liquefied petroleum gas (LPG) were enrolled...
January 24, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29337345/sputum-cytology-during-late-phase-responses-to-inhalation-challenge-with-different-allergens
#15
J A Revez, K J Killian, P M O'Byrne, L-P Boulet, J W Upham, G M Gauvreau, M A R Ferreira
BACKGROUND: In mouse models of allergic asthma, exposure to different allergens can trigger distinct inflammatory subtypes in the airways. We investigated whether this observation extends to humans. METHODS: We compared the frequency of sputum inflammatory subtypes between mild allergic asthma subjects (n = 129) exposed to different allergens in inhalation challenge tests. These tests were performed using a standardized protocol as part of clinical trials of experimental treatments for asthma, prior to drug randomization...
January 16, 2018: Allergy
https://www.readbyqxmd.com/read/29172277/dna-replication-licensing-proteins-for-early-detection-of-lung-cancer
#16
Veena V S, Rajan K, Saritha V N, Preethi Sara George, Chandramohan K, Jayasree K, Thara S, K Sujathan
Background: To identify and characterize malignant and premalignant cells in sputum and matched tissue samples with reference to expression of minichromosome maintenance proteins (MCM2, MCM5) and cell division cycle protein 6 (CDC 6) and to assess their potential as biomarkers of premalignant and malignant lesions of the lung and associations with clinicopathological features. Methods: Expression of MCM2, MCM5 and 6 proteins in sputum samples and corresponding tissues was assessed by immunocytochemistry, and correlated with histological findings...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29108319/detection-of-tumor-derived-dna-dispersed-in-the-airway-improves-the-diagnostic-accuracy-of-bronchoscopy-for-lung-cancer
#17
Taichiro Goto, Yosuke Hirotsu, Takahiro Nakagomi, Daichi Shikata, Yujiro Yokoyama, Kenji Amemiya, Toshiharu Tsutsui, Yumiko Kakizaki, Toshio Oyama, Hitoshi Mochizuki, Yoshihiro Miyashita, Masao Omata
The diagnostic accuracy of bronchoscopy for detecting lung cancer, especially peripheral lung cancer with lesions outside the endoscopically visible range, remains unsatisfactory. The aim of this study was to perform next-generation sequencing on bronchoscopic specimens to determine whether this improves the accuracy of bronchoscopy for diagnosing lung cancer and to identify factors influencing sensitivity. The bronchoscopic sensitivity for diagnosing lung cancer was initially evaluated in 191 patients who underwent lobectomy after bronchoscopy at our hospital...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29065541/screening-and-biosensor-based-approaches-for-lung-cancer-detection
#18
REVIEW
Lulu Wang
Early diagnosis of lung cancer helps to reduce the cancer death rate significantly. Over the years, investigators worldwide have extensively investigated many screening modalities for lung cancer detection, including computerized tomography, chest X-ray, positron emission tomography, sputum cytology, magnetic resonance imaging and biopsy. However, these techniques are not suitable for patients with other pathologies. Developing a rapid and sensitive technique for early diagnosis of lung cancer is urgently needed...
October 23, 2017: Sensors
https://www.readbyqxmd.com/read/28942912/an-evolving-role-for-cancer-rehabilitation-in-the-era-of-low-dose-lung-computed-tomography-screening
#19
REVIEW
Sean Robinson Smith, Ashish Khanna, Eric M Wisotzky
Lung cancer is the number one cause of cancer-related death worldwide, and is often detected in the later stages. Use of low-dose chest computed tomography in at-risk patients provides earlier detection and is being adopted as the standard screening tool, replacing less precise methods of radiography and sputum cytology. In the past, late detection of disease meant that rehabilitation interventions attempted to salvage function and to improve aerobic capacity to the point where patients could tolerate the sometimes-extensive oncologic treatment, including lobectomy or pneumonectomy...
September 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28914465/exploring-avenues-for-best-use-of-cytotechnologists-in-non-gynaecological-cytology-double-screening-or-independent-sign-out
#20
G Fischer, M Haddad, K Cormier
OBJECTIVE: Cytotechnologist (CT) screening workload has been decreasing due to the falling number of Papanicolaou tests. This continuing trend has prompted exploration of ways to best employ the CT skillset. One potential way of more effective use is by having two CTs double screen non-gynaecological (NGC) cases to assess whether this improves screening quality and concordance with pathologists. Another is evaluating the CT's performance on low-complexity negative NGC cases for a potential independent CT sign-out without pathologist review...
February 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
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