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Sputum cytology

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https://www.readbyqxmd.com/read/27899011/nasal-lavage-blood-or-sputum-which-is-best-for-phenotyping-asthma
#1
Camyla F de Farias, Maria M F Amorim, Michel Dracoulakis, Lilian B Caetano, Ilka L Santoro, Ana L G Fernandes
BACKGROUND AND OBJECTIVE: Determination of asthma phenotypes, particularly inflammatory phenotypes, helps guide treatment and management of this heterogeneous disease. Induced sputum cytology has been the gold standard for determination of inflammatory phenotypes, but sputum induction is fairly invasive and technically challenging. Blood and nasal lavage cytology have been suggested as substitutes, but have not been fully verified. The aim of this study is to determine the accuracy of blood and nasal lavage cytometry as indicators of inflammatory phenotypes in asthma...
November 29, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27891382/a-case-of-immune-thrombocytopenic-purpura-secondary-to-pulmonary-tuberculosis
#2
Sameer Panda, Lalit Kumar Meher, Siba Prasad Dalai, Sachidananda Nayak, Sujit Kumar Tripathy
The haematological abnormalities associated with active pulmonary tuberculosis were known to human beings since decades but Immune Thrombocytopenic Purpura (ITP) secondary to pulmonary tuberculosis have been reported only in a couple of instances. We report a 27 year-old male patient who was admitted to our hospital with fever, shortness of breath, haematuria, epistaxis and generalized petechiae. The sputum positivity for Acid Fast Bacilli (AFB) and chest X-ray reports were suggestive of active pulmonary tuberculosis in our patient...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27891048/metabolic-signatures-of-lung-cancer-in-sputum-and-exhaled-breath-condensate-detected-by-1-h-magnetic-resonance-spectroscopy-a-feasibility-study
#3
Naseer Ahmed, Tedros Bezabeh, Omkar B Ijare, Renelle Myers, Reem Alomran, Michel Aliani, Zoann Nugent, Shantanu Banerji, Julian Kim, Gefei Qing, Zoheir Bshouty
OBJECTIVES: Lung cancer is one of the most lethal cancers. Currently, there are no biomarkers for early detection, monitoring treatment response, and detecting recurrent lung cancer. We undertook this study to determine if (1)H magnetic resonance spectroscopy (MRS) of sputum and exhaled breath condensate (EBC), as a noninvasive tool, can identify metabolic biomarkers of lung cancer. MATERIALS AND METHODS: Sputum and EBC samples were collected from 20 patients, comprising patients with pathologically confirmed non-small cell lung cancer (n = 10) and patients with benign respiratory conditions (n = 10)...
2016: Magnetic Resonance Insights
https://www.readbyqxmd.com/read/27803750/alterations-of-pulmonary-function-in-patients-with-inflammatory-bowel-diseases
#4
Xiao-Qing Ji, Yan-Bo Ji, Shan-Xin Wang, Cai-Qing Zhang, De-Gan Lu
AIM: The aim of this study was to investigate the alterations of pulmonary function tests (PFTs) and their relationship with disease activity in inflammatory bowel diseases (IBDs). METHODS: Sixty-four IBD patients (31 Crohn's disease [CD] and 33 ulcerative colitis [UC]) and thirty healthy individuals (controls) were studied with regard to the following parameters of PFTs: Forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), their ratio, mid-forced expiratory flow of 25-75% (FEF 25-75), residual volume, total lung capacity, and diffusing capacity of the lung for carbon monoxide (DLCO)...
October 2016: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/27561242/utilization-of-ancillary-studies-in-the-cytologic-diagnosis-of-respiratory-lesions-the-papanicolaou-society-of-cytopathology-consensus-recommendations-for-respiratory-cytology
#5
Lester J Layfield, Sinchita Roy-Chowdhuri, Zubair Baloch, Hormoz Ehya, Kim Geisinger, Susan J Hsiao, Oscar Lin, Neal I Lindeman, Michael Roh, Fernando Schmitt, Nikoletta Sidiropoulos, Paul A VanderLaan
The Papanicolaou Society of Cytopathology has developed a set of guidelines for respiratory cytology including indications for sputum examination, bronchial washings and brushings, CT-guided FNA and endobronchial ultrasound guided fine needle aspiration (EBUS-FNA), as well as recommendations for classification and criteria, ancillary testing and post-cytologic diagnosis management and follow-up. All recommendation documents are based on the expertise of committee members, an extensive literature review, and feedback from presentations at national and international conferences...
December 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27546521/liquid-based-sputum-cytology-of-bicomponent-mucin-producing-adenocarcinoma-of-the-trachea-with-histologic-comparison
#6
Jeong-Hwa Kwon, Se Jin Jang, Joon Seon Song, Seung-Ho Choi, Kyung-Ja Cho
Primary tracheal adenocarcinomas are rare. Here, we report on the liquid-based sputum cytology of a bicomponent mucin-producing tracheal adenocarcinoma with histologic and immunohistochemical comparison. A 72-year-old man presented with dyspnea. Computed tomography revealed a lobulated mass in the mid-trachea. Sputum cytology showed clusters of atypical cuboidal cells that have pleomorphic and hyperchromatic nuclei and intracytoplasmic mucin. There were additional bland-looking components of regular clusters of cuboidal epithelial cells...
December 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27535387/lung-cancer-screening
#7
Geena X Wu, Dan J Raz
Lung cancer is the leading cause of cancer mortality in the United States and worldwide. Since lung cancer outcomes are dependent on stage at diagnosis with early disease resulting in longer survival, the goal of screening is to capture lung cancer in its early stages when it can be treated and cured. Multiple studies have evaluated the use of chest X-ray (CXR) with or without sputum cytologic examination for lung cancer screening, but none has demonstrated a mortality benefit. In contrast, the multicenter National Lung Screening Trial (NLST) from the United States found a 20 % reduction in lung cancer mortality following three consecutive screenings with low-dose computed tomography (LDCT) in high-risk current and former smokers...
2016: Cancer Treatment and Research
https://www.readbyqxmd.com/read/27500676/-analysis-of-the-effectiveness-of-the-spa-and-health-resort-based-treatment-of-the-patients-presenting-with-broncho-pulmonary-pathology-at-the-southern-coast-of-the-crimea-depending-on-the-period-of-flowering-of-mediterranean-cypress-cupressus-sempervirens
#8
V M Savchenko, S N Belyaeva, M I Govorun, M E Pirogova
AIM: The objective of the present study was to evaluate the influence of pollen of Mediterranean Cypress (Cupressus sempervirens) on the effectiveness of the spa and health resort-based treatment (SHRT) of the patients with broncho-pulmonary pathology at the southern coast of the Crimea (SCC). MATERIAL AND METHODS: This article presents the results of the analysis of the data on 122 patients presenting with broncho-pulmonary pathology who received SHRT under the conditions of the Southern Coast of the Crimea...
2016: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/27496969/dna-hypermethylation-analysis-in-sputum-of-asymptomatic-subjects-at-risk-for-lung-cancer-participating-in-the-nelson-trial-argument-for-maximum-screening-interval-of-2%C3%A2-years
#9
A Jasmijn Hubers, Daniëlle A M Heideman, Sylvia Duin, Birgit I Witte, Harry J de Koning, Harry J M Groen, Clemens F M Prinsen, Anne S Bolijn, Mandy Wouters, Susanne E van der Meer, Renske D M Steenbergen, Peter J F Snijders, Anne Uyterlinde, Hans Berkhof, Egbert F Smit, Erik Thunnissen
AIMS: Lung cancer is the major contributor to cancer mortality due to metastasised disease at time of presentation. The current study investigated DNA hypermethylation of biomarkers RASSF1A, APC, cytoglobin, 3OST2, FAM19A4, PHACTR3 and PRDM14 in sputum of asymptomatic high-risk individuals from the NELSON lung cancer low-dose spiral CT screening trial to detect lung cancer at preclinical stage. METHODS: Subjects were selected with (i) lung cancer in follow-up (cases; n=65), (ii) minor cytological aberrations (controls; n=120) and (iii) a random selection of subjects without cytological aberrations (controls; n=99)...
August 5, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27274093/induced-sputum-analysis-in-subjects-with-systemic-sclerosis
#10
Irena Litinsky, Elizabeth Fireman, Daphna Paran, Ari Polachek, Adi Broide, Amir Sharabi, Marina Anouk, Ori Elkayam
BACKGROUND: Induced sputum is a noninvasive tool, aimed at collecting cellular and soluble materials from lung airways. Induced sputum sampling analysis has been validated in chronic obstructive lung diseases as well as in various diffuse interstitial lung disorders. Our objective was to evaluate the utility of induced sputum speciments of cellular and soluble materials noninvasively sampled from the lung airways of subjects with systemic sclerosis compared with healthy controls and determine possible correlation with disease manifestations...
October 2016: Respiratory Care
https://www.readbyqxmd.com/read/27158468/early-detection-of-lung-cancer
#11
REVIEW
David E Midthun
Most patients with lung cancer are diagnosed when they present with symptoms, they have advanced stage disease, and curative treatment is no longer an option. An effective screening test has long been desired for early detection with the goal of reducing mortality from lung cancer. Sputum cytology, chest radiography, and computed tomography (CT) scan have been studied as potential screening tests. The National Lung Screening Trial (NLST) demonstrated a 20% reduction in mortality with low-dose CT (LDCT) screening, and guidelines now endorse annual LDCT for those at high risk...
2016: F1000Research
https://www.readbyqxmd.com/read/27130532/screening-for-lung-cancer-a-systematic-review-and-meta-analysis
#12
REVIEW
Muhammad Usman Ali, John Miller, Leslea Peirson, Donna Fitzpatrick-Lewis, Meghan Kenny, Diana Sherifali, Parminder Raina
OBJECTIVES: To examine evidence on benefits and harms of screening average to high-risk adults for lung cancer using chest radiology (CXR), sputum cytology (SC) and low-dose computed tomography (LDCT). METHODS: This systematic review was conducted to provide up to date evidence for Canadian Task Force on Preventive Health Care (CTFPHC) lung cancer screening guidelines. Four databases were searched to March 31, 2015 along with utilizing a previous Cochrane review search...
August 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27010397/plag-1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol-modulates-eosinophil-chemotaxis-by-regulating-ccl26-expression-from-epithelial-cells
#13
Jinseon Jeong, Young-Jun Kim, Sun Young Yoon, Yong-Jae Kim, Joo Heon Kim, Ki-Young Sohn, Heung-Jae Kim, Yong-Hae Han, Saeho Chong, Jae Wha Kim
Increased number of eosinophils in the circulation and sputum is associated with the severity of asthma. The respiratory epithelium produces chemokine (C-C motif) ligands (CCL) which recruits and activates eosinophils. A chemically synthesized monoacetyl-diglyceride, PLAG (1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol) is a major constituent in the antlers of Sika deer (Cervus nippon Temminck) which has been used in oriental medicine. This study was aimed to investigate the molecular mechanism of PLAG effect on the alleviation of asthma phenotypes...
2016: PloS One
https://www.readbyqxmd.com/read/26972585/cytological-diagnosis-of-adult-t-cell-leukemia-lymphoma-in-sputum
#14
Jia Qin, Jinli Liu, Constantine A Axiotis
Adult T-cell leukemia/lymphoma (ATLL) is a rare and often aggressive T-cell leukemia/lymphoma that has been linked to infection by the human T-cell lymphotropic virus type 1 (HTLV-1). ATLL can involve multiple organs including the respiratory airway. A 53-year-old Trinidadian woman presented with productive cough and progressive shortness of breath. Her past medical history included duodenal strongyloidosis, skin rash, and hypercalcemia. Radiological studies showed increased interstitial markings. Sputum cytology showed atypical pleomorphic, small-to-medium-sized, lobated lymphocytes with irregular and hyperchromatic nuclei resembling "flower cells" which were CD3±/CD20- by immunocytochemistry...
May 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/26951732/-lung-cancer-screening-in-high-risk-subjects-early-detection-with-ldct-and-risk-stratification-using-mirna-based-blood-test
#15
Stefano Sestini, Mattia Boeri, Alfonso Marchianò, Mario Silva, Giuseppina Calareso, Carlotta Galeone, Gabriella Sozzi, Ugo Pastorino
Lung cancer still remains a high mortality disease in the face of developments in diagnostic and therapeutic methods that occurred in the last 20 years. The analysis of the experiences from the first studies - in which chest X-ray (CXR) was adopted, associated or not with sputum cytology - has failed to show a reduction in lung cancer specific mortality. Subsequent screening studies that have introduced the use of low-dose computed tomography (LDCT) have revealed a large number of early-stage lung cancers, thus potentially curable; however, this has not allowed us to demonstrate a decrease in lung cancer-specific mortality...
January 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/26883543/asthma-control-and-airway-inflammation-in-patients-with-eosinophilic-granulomatosis-with-polyangiitis
#16
Manuela Latorre, Chiara Baldini, Veronica Seccia, Pasquale Pepe, Federica Novelli, Alessandro Celi, Elena Bacci, Silvana Cianchetti, Federico L Dente, Stefano Bombardieri, Pierluigi Paggiaro
BACKGROUND: Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic necrotizing vasculitis that occurs in patients with asthma, nasal disease, blood and tissue eosinophilia, and extrapulmonary manifestations. OBJECTIVE: The aim of our study was to assess the clinical, functional, and inflammatory status of upper and lower airways in 37 patients with EGPA, examined 6.4 ± 4.7 years after diagnosis, when they were in partial or complete remission from systemic involvement while on treatment with low-dose oral corticosteroids as maintenance therapy...
May 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/26774146/the-value-of-shox2-methylation-test-in-peripheral-blood-samples-used-for-the-differential-diagnosis-of-lung-cancer-and-other-lung-disorders
#17
M Konecny, J Markus, I Waczulikova, L Dolesova, R Kozlova, V Repiska, H Novosadova, I Majer
Methylation of the cytosine residues within the CpG dinucleotides plays an important role in the fundamental cellular processes, human diseases and even cancer. The DNA methylation represents a very stable sign and therefore may be used as a valuable marker for cancer screening. Epigenetic cancer biomarkers are independent of classical morphology and thus show extensive potential to overcome the limitations of cytology. Several epigenetic cancer markers have been reported to be detectable in body fluids such as bronchial aspirate, sputum, plasma and serum...
2016: Neoplasma
https://www.readbyqxmd.com/read/26744666/pneumonia-lung-cancer-or-medlar-s-core
#18
Filippo Luciani, Flavio Fedele, Andrea Corsonello, Michele Florio, Salvatore De Santis, Elena Guzzo, Mariarita Perri, Maria Cristina Caroleo, Roberto Cannataro, Erika Cione
Here, we report a case of 57-year-old previously healthy man with six-months medical history of significant chronic cough and recurring episodes of fever. Cytology, bacteria, fungi and acid fast bacilli in the sputum were negative. CT scan, initially interpreted as suspected lung cancer, detected by chest x-ray, revealed pneumonia. Bronchoscopy is frequently necessary for the diagnosis as well as the treatment as a routine practice and in this case was applied. Our patient underwent to fiberoptic rigid bronchoscopy in the right upper lobe in general anaesthesia...
2015: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/26729975/the-utility-of-cytology-in-the-diagnosis-of-adenocarcinoma-lung-a-tertiary-care-center-study
#19
Saumya Shukla, Kiran Preet Malhotra, Nuzhat Husain, Anurag Gupta, Nidhi Anand
INTRODUCTION: Pulmonary adenocarcinoma harbors various molecular abnormalities that include epidermal growth factor mutation, anaplastic lymphoma kinase gene re-arrangement, K-RAS mutations. The availability of targeted therapy against these molecular markers has revolutionized personalized medicine. Accurate cytological diagnosis of pulmonary adenocarcinoma will aid in utilising the cytology smears for molecular testing. OBJECTIVE: The objective of this retrospective study was to evaluate the diagnostic efficacy of various cytology samples in the diagnosis of pulmonary adenocarcinoma...
July 2015: Journal of Cytology
https://www.readbyqxmd.com/read/26678320/infection-and-inflammation-in-induced-sputum-from-preschool-children-with-chronic-airways-diseases
#20
Anja Jochmann, Luca Artusio, Karen Robson, Prasad Nagakumar, Nicola Collins, Louise Fleming, Andrew Bush, Sejal Saglani
BACKGROUND: We hypothesized airway inflammation can be detected non-invasively by induced sputum (IS) or peripheral blood eosinophilia, and IS can detect bacterial and viral infection in preschool children with airway disease, with results comparable to broncho-alveolar lavage (BAL). METHODS: Preschool children with cystic fibrosis, recurrent wheeze, or wet cough underwent IS with nebulized hypertonic saline, chest physiotherapy, and oropharyngeal suction. Samples were analyzed for inflammation by cytology and bacterial culture, viral detection by PCR...
August 2016: Pediatric Pulmonology
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