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Sputum cytology

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https://www.readbyqxmd.com/read/28596492/detection-of-tumor-derived-dna-dispersed-in-the-airway-improves-the-diagnostic-accuracy-of-bronchoscopy-for-lung-cancer
#1
Taichiro Goto, Yosuke Hirotsu, Takahiro Nakagomi, Daichi Shikata, Yujiro Yokoyama, Kenji Amemiya, Toshiharu Tsutsui, Yumiko Kakizaki, Toshio Oyama, Hitoshi Mochizuki, Yoshihiro Miyashita, Masao Omata
The diagnostic accuracy of bronchoscopy for detecting lung cancer, especially peripheral lung cancer with lesions outside the endoscopically visible range, remains unsatisfactory. The aim of this study was to perform next-generation sequencing on bronchoscopic specimens to determine whether this improves the accuracy of bronchoscopy for diagnosing lung cancer and to identify factors influencing sensitivity. The bronchoscopic sensitivity for diagnosing lung cancer was initially evaluated in 191 patients who underwent lobectomy after bronchoscopy at our hospital...
May 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28535501/is-the-morning-sputum-sample-superior-to-the-fresh-sputum-sample-for-the-detection-of-malignant-cells
#2
Maya S Uke, Saleem Pathuthara, Abida Shaikh, Rajiv Kumar, Shubhada Kane
INTRODUCTION: Sputum cytology is a well-established technique for the detection of lung malignancies. Generally, random or morning samples are used. OBJECTIVES: To evaluate the diagnostic yield of morning sputum and compare it with that of fresh samples. MATERIALS AND METHODS: Patients were instructed to bring a morning sputum sample to the laboratory in a clean plastic container, without any fixative and within 2-3 h of collection. Fresh sputum was then collected in the laboratory from these same patients...
2017: Acta Cytologica
https://www.readbyqxmd.com/read/28410823/the-case-for-performing-pleural-biopsies-for-the-aetiological-diagnosis-of-exudates-yes
#3
F Rodriguez-Panadero
Pleural biopsies are especially indicated in the following circumstances: a) inconclusive pleural fluid analysis and negative sputum study, if adenosine deaminase (ADA) levels are unavailable; b) suspected multi-resistant tuberculosis; c) a need for differentiating tuberculous pleurisy (if it progresses with neutrophilia) and complicated parapneumonic effusion; d) malignant pleural effusion coexisting with very high ADA levels; e) effusion coexisting with lung cancer and negative pleural cytology; f) suspected mesothelioma; and g) need for implementing re-treatment for patients with relapse after chemotherapy...
April 12, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28281441/miliary-tuberculosis
#4
Surendra K Sharma, Alladi Mohan
Miliary tuberculosis (TB) results from a massive lymphohematogenous dissemination of Mycobacterium tuberculosis bacilli and is characterized by tiny tubercles evident on gross pathology resembling millet seeds in size and appearance. The global HIV/AIDS pandemic and widespread use of immunosuppressive drugs and biologicals have altered the epidemiology of miliary TB. Considered to be predominantly a disease of infants and children in the pre-antibiotic era, miliary TB is increasingly being encountered in adults as well...
March 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28275538/analysis-of-significantly-mutated-genes-as-a-clinical-tool-for-the-diagnosis-in-a-case-of-lung-cancer
#5
Yoshihiro Miyashita, Yosuke Hirotsu, Toshiharu Tsutsui, Seishi Higashi, Yusuke Sogami, Yumiko Kakizaki, Taichiro Goto, Kenji Amemiya, Toshio Oyama, Masao Omata
Bronchoendoscopic examination is not necessarily comfortable procedure and limited by its sensitivity, depending on the location and size of the tumor lesion. Patients with a non-diagnostic bronchoendoscopic examination often undergo further invasive examinations. Non-invasive diagnostic tool of lung cancer is desired. A 72-year-old man had a 3.0 cm × 2.5 cm mass lesion in the segment B1 of right lung. Cytological examination of sputum, bronchial washing and curetted samples were all "negative". We could confirm a diagnosis of lung cancer after right upper lung lobe resection pathologically, and also obtained concordant results by genomic analysis using cytological negative samples from airways collected before operation...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28077110/the-first-rib-hypoplasia-and-the-aberrant-pulmonary-artery-branch-detected-by-three-dimensional-computed-tomography-in-a-surgical-case-with-apical-lung-cancer-a-case-report
#6
Yasoo Sugiura, Hiroyuki Fujimoto, Masao Naruke, Toshinori Hashizume, Shizuka Kaseda, Etsuo Nemoto
BACKGROUND: The complete resection is one of the most crucial requirements to achieve favorable outcomes in oncologic surgery. The apex of the lung is surrounded complicatedly by the clavicle, the first rib, the subclavian artery and vein, and the brachial plexus. Therefore, the image information especially about the infiltration of adjacent anatomic structures, facilitates the surgery in the apical lung cancer. CASE PRESENTATION: A 70-year-old man presented at our hospital with a computed tomography (CT) scan showing a tumor at the left lung apex that infiltrated the chest wall...
January 11, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28069248/race-is-associated-with-differences-in-airway-inflammation-in-patients-with-asthma
#7
Sharmilee M Nyenhuis, Jerry A Krishnan, Alalia Berry, William J Calhoun, Vernon M Chinchilli, Linda Engle, Nicole Grossman, Fernando Holguin, Elliot Israel, Rick A Kittles, Monica Kraft, Stephen C Lazarus, Erik B Lehman, David T Mauger, James N Moy, Stephen P Peters, Wanda Phipatanakul, Lewis J Smith, Kaharu Sumino, Stanley J Szefler, Michael E Wechsler, Sally Wenzel, Steven R White, Steven J Ackerman
BACKGROUND: African American subjects have a greater burden from asthma compared with white subjects. Whether the pattern of airway inflammation differs between African American and white subjects is unclear. OBJECTIVE: We sought to compare sputum airway inflammatory phenotypes of African American and white subjects treated or not with inhaled corticosteroids (ICSs; ICS+ and ICS-, respectively). METHODS: We performed a secondary analysis of self-identified African American and white subjects with asthma enrolled in clinical trials conducted by the National Heart, Lung, and Blood Institute-sponsored Asthma Clinical Research Network and AsthmaNet...
December 31, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28008666/detection-of-cryptococcosis-in-liquid-based-sputum-cytology
#8
S Sharma, N Gupta, D Behera, A Rajwanshi
No abstract text is available yet for this article.
April 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/27899011/nasal-lavage-blood-or-sputum-which-is-best-for-phenotyping-asthma
#9
Camyla F de Farias, Maria M F Amorim, Michel Dracoulakis, Lilian B Caetano, Ilka L Santoro, Ana L G Fernandes
BACKGROUND AND OBJECTIVE: Determination of asthma phenotypes, particularly inflammatory phenotypes, helps guide treatment and management of this heterogeneous disease. Induced sputum cytology has been the gold standard for determination of inflammatory phenotypes, but sputum induction is fairly invasive and technically challenging. Blood and nasal lavage cytology have been suggested as substitutes, but have not been fully verified. The aim of this study is to determine the accuracy of blood and nasal lavage cytometry as indicators of inflammatory phenotypes in asthma...
May 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27891382/a-case-of-immune-thrombocytopenic-purpura-secondary-to-pulmonary-tuberculosis
#10
Sameer Panda, Lalit Kumar Meher, Siba Prasad Dalai, Sachidananda Nayak, Sujit Kumar Tripathy
The haematological abnormalities associated with active pulmonary tuberculosis were known to human beings since decades but Immune Thrombocytopenic Purpura (ITP) secondary to pulmonary tuberculosis have been reported only in a couple of instances. We report a 27 year-old male patient who was admitted to our hospital with fever, shortness of breath, haematuria, epistaxis and generalized petechiae. The sputum positivity for Acid Fast Bacilli (AFB) and chest X-ray reports were suggestive of active pulmonary tuberculosis in our patient...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27891048/metabolic-signatures-of-lung-cancer-in-sputum-and-exhaled-breath-condensate-detected-by-1-h-magnetic-resonance-spectroscopy-a-feasibility-study
#11
Naseer Ahmed, Tedros Bezabeh, Omkar B Ijare, Renelle Myers, Reem Alomran, Michel Aliani, Zoann Nugent, Shantanu Banerji, Julian Kim, Gefei Qing, Zoheir Bshouty
OBJECTIVES: Lung cancer is one of the most lethal cancers. Currently, there are no biomarkers for early detection, monitoring treatment response, and detecting recurrent lung cancer. We undertook this study to determine if (1)H magnetic resonance spectroscopy (MRS) of sputum and exhaled breath condensate (EBC), as a noninvasive tool, can identify metabolic biomarkers of lung cancer. MATERIALS AND METHODS: Sputum and EBC samples were collected from 20 patients, comprising patients with pathologically confirmed non-small cell lung cancer (n = 10) and patients with benign respiratory conditions (n = 10)...
2016: Magnetic Resonance Insights
https://www.readbyqxmd.com/read/27803750/alterations-of-pulmonary-function-in-patients-with-inflammatory-bowel-diseases
#12
Xiao-Qing Ji, Yan-Bo Ji, Shan-Xin Wang, Cai-Qing Zhang, De-Gan Lu
AIM: The aim of this study was to investigate the alterations of pulmonary function tests (PFTs) and their relationship with disease activity in inflammatory bowel diseases (IBDs). METHODS: Sixty-four IBD patients (31 Crohn's disease [CD] and 33 ulcerative colitis [UC]) and thirty healthy individuals (controls) were studied with regard to the following parameters of PFTs: Forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), their ratio, mid-forced expiratory flow of 25-75% (FEF 25-75), residual volume, total lung capacity, and diffusing capacity of the lung for carbon monoxide (DLCO)...
October 2016: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/27561242/utilization-of-ancillary-studies-in-the-cytologic-diagnosis-of-respiratory-lesions-the-papanicolaou-society-of-cytopathology-consensus-recommendations-for-respiratory-cytology
#13
Lester J Layfield, Sinchita Roy-Chowdhuri, Zubair Baloch, Hormoz Ehya, Kim Geisinger, Susan J Hsiao, Oscar Lin, Neal I Lindeman, Michael Roh, Fernando Schmitt, Nikoletta Sidiropoulos, Paul A VanderLaan
The Papanicolaou Society of Cytopathology has developed a set of guidelines for respiratory cytology including indications for sputum examination, bronchial washings and brushings, CT-guided FNA and endobronchial ultrasound guided fine needle aspiration (EBUS-FNA), as well as recommendations for classification and criteria, ancillary testing and post-cytologic diagnosis management and follow-up. All recommendation documents are based on the expertise of committee members, an extensive literature review, and feedback from presentations at national and international conferences...
December 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27546521/liquid-based-sputum-cytology-of-bicomponent-mucin-producing-adenocarcinoma-of-the-trachea-with-histologic-comparison
#14
Jeong-Hwa Kwon, Se Jin Jang, Joon Seon Song, Seung-Ho Choi, Kyung-Ja Cho
Primary tracheal adenocarcinomas are rare. Here, we report on the liquid-based sputum cytology of a bicomponent mucin-producing tracheal adenocarcinoma with histologic and immunohistochemical comparison. A 72-year-old man presented with dyspnea. Computed tomography revealed a lobulated mass in the mid-trachea. Sputum cytology showed clusters of atypical cuboidal cells that have pleomorphic and hyperchromatic nuclei and intracytoplasmic mucin. There were additional bland-looking components of regular clusters of cuboidal epithelial cells...
December 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27535387/lung-cancer-screening
#15
REVIEW
Geena X Wu, Dan J Raz
Lung cancer is the leading cause of cancer mortality in the United States and worldwide. Since lung cancer outcomes are dependent on stage at diagnosis with early disease resulting in longer survival, the goal of screening is to capture lung cancer in its early stages when it can be treated and cured. Multiple studies have evaluated the use of chest X-ray (CXR) with or without sputum cytologic examination for lung cancer screening, but none has demonstrated a mortality benefit. In contrast, the multicenter National Lung Screening Trial (NLST) from the United States found a 20 % reduction in lung cancer mortality following three consecutive screenings with low-dose computed tomography (LDCT) in high-risk current and former smokers...
2016: Cancer Treatment and Research
https://www.readbyqxmd.com/read/27500676/-analysis-of-the-effectiveness-of-the-spa-and-health-resort-based-treatment-of-the-patients-presenting-with-broncho-pulmonary-pathology-at-the-southern-coast-of-the-crimea-depending-on-the-period-of-flowering-of-mediterranean-cypress-cupressus-sempervirens
#16
V M Savchenko, S N Belyaeva, M I Govorun, M E Pirogova
AIM: The objective of the present study was to evaluate the influence of pollen of Mediterranean Cypress (Cupressus sempervirens) on the effectiveness of the spa and health resort-based treatment (SHRT) of the patients with broncho-pulmonary pathology at the southern coast of the Crimea (SCC). MATERIAL AND METHODS: This article presents the results of the analysis of the data on 122 patients presenting with broncho-pulmonary pathology who received SHRT under the conditions of the Southern Coast of the Crimea...
2016: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/27496969/dna-hypermethylation-analysis-in-sputum-of-asymptomatic-subjects-at-risk-for-lung-cancer-participating-in-the-nelson-trial-argument-for-maximum-screening-interval-of-2%C3%A2-years
#17
RANDOMIZED CONTROLLED TRIAL
A Jasmijn Hubers, Daniëlle A M Heideman, Sylvia Duin, Birgit I Witte, Harry J de Koning, Harry J M Groen, Clemens F M Prinsen, Anne S Bolijn, Mandy Wouters, Susanne E van der Meer, Renske D M Steenbergen, Peter J F Snijders, Anne Uyterlinde, Hans Berkhof, Egbert F Smit, Erik Thunnissen
AIMS: Lung cancer is the major contributor to cancer mortality due to metastasised disease at time of presentation. The current study investigated DNA hypermethylation of biomarkers RASSF1A, APC, cytoglobin, 3OST2, FAM19A4, PHACTR3 and PRDM14 in sputum of asymptomatic high-risk individuals from the NELSON lung cancer low-dose spiral CT screening trial to detect lung cancer at preclinical stage. METHODS: Subjects were selected with (i) lung cancer in follow-up (cases; n=65), (ii) minor cytological aberrations (controls; n=120) and (iii) a random selection of subjects without cytological aberrations (controls; n=99)...
March 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27274093/induced-sputum-analysis-in-subjects-with-systemic-sclerosis
#18
Irena Litinsky, Elizabeth Fireman, Daphna Paran, Ari Polachek, Adi Broide, Amir Sharabi, Marina Anouk, Ori Elkayam
BACKGROUND: Induced sputum is a noninvasive tool, aimed at collecting cellular and soluble materials from lung airways. Induced sputum sampling analysis has been validated in chronic obstructive lung diseases as well as in various diffuse interstitial lung disorders. Our objective was to evaluate the utility of induced sputum speciments of cellular and soluble materials noninvasively sampled from the lung airways of subjects with systemic sclerosis compared with healthy controls and determine possible correlation with disease manifestations...
October 2016: Respiratory Care
https://www.readbyqxmd.com/read/27158468/early-detection-of-lung-cancer
#19
REVIEW
David E Midthun
Most patients with lung cancer are diagnosed when they present with symptoms, they have advanced stage disease, and curative treatment is no longer an option. An effective screening test has long been desired for early detection with the goal of reducing mortality from lung cancer. Sputum cytology, chest radiography, and computed tomography (CT) scan have been studied as potential screening tests. The National Lung Screening Trial (NLST) demonstrated a 20% reduction in mortality with low-dose CT (LDCT) screening, and guidelines now endorse annual LDCT for those at high risk...
2016: F1000Research
https://www.readbyqxmd.com/read/27130532/screening-for-lung-cancer-a-systematic-review-and-meta-analysis
#20
REVIEW
Muhammad Usman Ali, John Miller, Leslea Peirson, Donna Fitzpatrick-Lewis, Meghan Kenny, Diana Sherifali, Parminder Raina
OBJECTIVES: To examine evidence on benefits and harms of screening average to high-risk adults for lung cancer using chest radiology (CXR), sputum cytology (SC) and low-dose computed tomography (LDCT). METHODS: This systematic review was conducted to provide up to date evidence for Canadian Task Force on Preventive Health Care (CTFPHC) lung cancer screening guidelines. Four databases were searched to March 31, 2015 along with utilizing a previous Cochrane review search...
August 2016: Preventive Medicine
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