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https://www.readbyqxmd.com/read/29156212/history-and-purpose-of-postpartum-support-international
#1
Wendy Newhouse Davis, Christena Raines, Pec Indman, Birdie Gunyon Meyer, Ann Smith
Postpartum Support International provides training for professionals and supports families who experience perinatal mood and anxiety disorders. The purpose of this article is to describe Postpartum Support International, which was founded in 1987 to increase awareness among public and professional communities about the emotional difficulties women experience during and after pregnancy. We recommend strategies with which health care professionals can support families, reduce stigma, and offer resources for treatment and support...
November 17, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/29156097/4-aminopyridine-a-pan-kv-channel-inhibitor-that-enhances-kv7-4-currents-and-inhibits-noradrenaline-mediated-contraction-of-rat-mesenteric-small-arteries
#2
Makhala M Khammy, Sukhan Kim, Bo H Bentzen, Soojung Lee, Inyeoung Choi, Christian Aalkjaer, Thomas A Jepps
BACKGROUND AND PURPOSE: Kv7.4 and Kv7.5 channels are regulators of vascular tone. 4-aminopyridine (4-AP) is considered a broad inhibitor of voltage-gated potassium (KV ) channels, with little inhibitory effect on Kv7 family members at millimolar concentrations. However, the effect of 4-AP on Kv7 channels has not been systematically studied. The aim of this study was to investigate the pharmacological activity of 4-AP on Kv7.4 and Kv7.5 channels and characterise the effect of 4-AP on rat resistance arteries...
November 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29155946/gpcrdb-in-2018-adding-gpcr-structure-models-and-ligands
#3
Gáspár Pándy-Szekeres, Christian Munk, Tsonko M Tsonkov, Stefan Mordalski, Kasper Harpsøe, Alexander S Hauser, Andrzej J Bojarski, David E Gloriam
G protein-coupled receptors are the most abundant mediators of both human signalling processes and therapeutic effects. Herein, we report GPCRome-wide homology models of unprecedented quality, and roughly 150 000 GPCR ligands with data on biological activities and commercial availability. Based on the strategy of 'Less model - more Xtal', each model exploits both a main template and alternative local templates. This achieved higher similarity to new structures than any of the existing resources, and refined crystal structures with missing or distorted regions...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29155464/both-life-history-plasticity-and-local-adaptation-will-shape-range-wide-responses-to-climate-warming-in-the-tundra-plant-silene-acaulis
#4
Megan L Peterson, Daniel F Doak, William F Morris
Many predictions of how climate change will impact biodiversity have focused on range shifts using species-wide climate tolerances, an approach that ignores the demographic mechanisms that enable species to attain broad geographic distributions. But these mechanisms matter, as responses to climate change could fundamentally differ depending on the contributions of life history plasticity vs local adaptation to species-wide climate tolerances. In particular, if local adaptation to climate is strong, populations across a species' range - not only those at the trailing range edge - could decline sharply with global climate change...
November 20, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29155317/treosulfan-fludarabine-conditioning-for-hsct-in-children-with-primary-immunodeficiency-uk-experience
#5
Mary A Slatter, Kanchan Rao, Intan Juliana Abd Hamid, Zohreh Nademi, Robert Chiesa, Reem Elfeky, Mark S Pearce, Persis Amrolia, Austen Worth, Terence Flood, Mario Abinun, Sophie Hambleton, Waseem Qasim, Hubert B Gaspar, Andrew J Cant, Andrew R Gennery, Paul Veys
We previously published results of 70 children who received treosulfan with cyclophosphamide (30) or fludarabine (40) before haematopoietic stem cell transplantation (HSCT) for Primary Immunodeficiency (PID). Toxicity was lower and T cell chimerism better in those receiving fludarabine, but numbers were relatively small and follow-up short. We now report outcome of 160 children who received homogeneous conditioning with treosulfan, fludarabine mostly with alemtuzumab (n=124). Median age at transplant was 1...
November 16, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29155172/navigating-motherhood-and-maternal-transitional-infant-feeding-learnings-for-health-professionals
#6
Michelle Harrison, Julie Hepworth, Wendy Brodribb
Given the lifelong associations between infant diet and weight, understanding maternal transitional infant feeding decisions can assist efforts to establish healthy eating habits early in life. Feeding experiences were explored using semi-structured interviews with 15 first-time mothers who were selected based on their concerns about their infants' weight in an infant feeding survey. Thematic synthesis of the interview transcripts identified three main themes: Theme 1. Expectations of a "responsible mother", (2) Trusting oneself and trust in others, and (3) From stress to successful feeding...
November 16, 2017: Appetite
https://www.readbyqxmd.com/read/29154608/a-life-stress-emotional-awareness-and-expression-interview-for-primary-care-patients-with-medically-unexplained-symptoms-a-randomized-controlled-trial
#7
Maisa S Ziadni, Jennifer N Carty, Heather K Doherty, John H Porcerelli, Lisa J Rapport, Howard Schubiner, Mark A Lumley
OBJECTIVE: Lifetime trauma, relationship adversities, and emotional conflicts are elevated in primary care patients with medically unexplained symptoms (MUS), and these risk factors likely trigger or exacerbate symptoms. Helping patients disclose stressors, increase awareness and expression of inhibited emotions, and link emotions to physical symptoms may improve health. We developed an emotional awareness and expression interview that targets stressful life experiences and conflicts and then tested its effects on primary care patients with MUS...
November 20, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29154509/technology-assisted-rehabilitation-interventions-following-pediatric-brain-injury
#8
Shari L Wade, Megan E Narad, Emily L Shultz, Brad G Kurowski, Aimee E Miley, Jessica M Aguilar, Anna-Lynne R Adlam
INTRODUCTION: Following traumatic brain injury (TBI), children experience a variety of physical, motor, speech, and cognitive deficits that can have a long-term detrimental impact. The emergence and popularity of new technologies has led to research into the development of various apps, gaming systems, websites, and robotics that might be applied to rehabilitation. The objective of this narrative review was to describe the current literature technologically-assisted interventions for the rehabilitation of motor, neurocognitive, behavioral, and family impairments following pediatric TBI...
November 20, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29154142/child-trafficking-and-the-european-migration-crisis-the-role-of-forensic-practitioners
#9
Zuzana Obertová, Cristina Cattaneo
Trafficking in children is one of the worst forms of human rights violation and is categorised as a serious crime. Children at high risk of becoming victims of trafficking are runaways, children with a history of abuse, and migrant children. Internationally, cases of child trafficking are increasing the most in Europe, which is likely the result of the current migration crisis. In crises, preventing and combating human trafficking needs to be prioritized, considering that the aims of humanitarian action include saving lives, easing suffering and preserving human dignity...
November 4, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29153934/family-centered-care-from-the-perspective-of-parents-of-children-cared-for-in-a-pediatric-intensive-care-unit-an-integrative-review
#10
REVIEW
Carrie Hill, Kathleen A Knafl, Sheila Judge Santacroce
PROBLEM: The Institute for Patient- and Family-Centered Care's (IPFCC) definition of family-centered care (FCC) includes the following four core concepts: respect and dignity, information sharing, participation, and collaboration. To date, research has focused on the provider experience of FCC in the PICU; little is known about how parents of children hospitalized in the pediatric intensive care unit (PICU) experience FCC. ELIGIBILITY CRITERIA: Articles were included if they were published between 2006 and 2016, included qualitative, quantitative, or mixed methods results, related to care received in a PICU, and included results that were from a parent perspective...
November 16, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29153298/barriers-to-optimal-pain-management-in-aged-care-facilities-an-australian-qualitative-study
#11
Felicity Veal, Mackenzie Williams, Luke Bereznicki, Elizabeth Cummings, Angus Thompson, Gregory Peterson, Tania Winzenberg
Up to 80% of residents in aged care facilities (ACFs) experience pain, which is often suboptimally managed. To characterize pain management in ACFs and identify the barriers to optimal pain management. An exploratory descriptive qualitative study using semistructured interviews. Five Southern Tasmania, Australian ACFs. 23 staff members (18 nurses and 5 facility managers). Interviews were conducted from September to November 2015. Interviews included questions about how pain was measured or assessed, what happened if pain was identified, barriers to pain management, and potential ways to overcome these barriers...
November 15, 2017: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29153077/twitter-101-and-beyond-introduction-to-social-media-platforms-available-to-practicing-hematologist-oncologists
#12
REVIEW
Michael A Thompson, Jenny Ahlstrom, Don S Dizon, Yash Gad, Greg Matthews, Howard J Luks, Andrew Schorr
Social media utilizes specific media platforms to allow increased interactivity between participants. These platforms serve diverse groups and purposes including participation from patients, family caregivers, research scientists, physicians, and pharmaceutical companies. Utilization of these information outlets has increased with integration at conferences and between conferences with the use of hashtags and "chats". In the realm of the "e-Patient" it is key to not underestimate your audience. Highly technical information is just as useful as a basic post...
October 2017: Seminars in Hematology
https://www.readbyqxmd.com/read/29153010/family-experiences-and-sexual-victimization-histories-a-comparative-analysis-between-youth-sexual-and-nonsexual-offenders
#13
Jamie Yoder, Rebecca Dillard, George S Leibowitz
Youth who commit sexual offenses often have sexual victimization histories that occur in the family context. These victimization experiences can be exacerbated by other risks present in the family environment. This research study uses MANOVAs to explore how family environments including substance use, mental health, physical and emotional victimization experiences, attachment, and parenting styles differentiate subgroups of youth offenders including youth sexual offenders with ( n = 179) and without ( n = 176) sexual victimization histories, and nonsexual offenders without sexual victimization histories ( n = 150)...
November 1, 2017: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/29153009/mothers-perspectives-on-the-lived-experience-of-children-with-intellectual-disability-and-challenging-behaviour
#14
Joann Kiernan, Duncan Mitchell, Jois Stansfield, Carol Taylor
Children with intellectual disability and behavioural needs (challenging behaviour) are vulnerable to exclusion from services and communities. The situation is exacerbated by difficulties in accessing appropriate support and services to effectively meet the needs of children and carers. Family perspectives on the 'lived experience' of children can provide insight into how behavioural needs can affect their ability to access everyday experiences. Semi-structured interviews were conducted with mothers of children with intellectual disabilities and challenging behaviours...
January 1, 2017: Journal of Intellectual Disabilities: JOID
https://www.readbyqxmd.com/read/29152993/program-experiences-of-adults-with-autism-their-families-and-providers-findings-from-a-focus-group-study
#15
Kaitlin H Koffer Miller, Mary Mathew, Stacy L Nonnemacher, Lindsay L Shea
A growing number of individuals with autism spectrum disorder are aging into adulthood. In the United States, Medicaid is the primary payer for services for adults with autism spectrum disorder, yet there are few funded programs that provide dedicated supports to this population. This study examined the experiences of adults with autism spectrum disorder in two Medicaid-funded programs in Pennsylvania through focus groups. Researchers conducted 20 focus groups with a total of 36 adults with autism spectrum disorder, 32 family members, 32 direct care staff, and 20 program administrators...
February 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/29152459/marking-15-years-of-the-genetic-and-rare-diseases-information-center
#16
Janine Lewis, Michelle Snyder, Henrietta Hyatt-Knorr
BACKGROUND: The Genetic and Rare Diseases Information Center (GARD), a program of the National Center for Advancing Translational Sciences, was established in 2002 to assist the public in finding reliable, timely, and easy-to-understand information about genetic and/or rare diseases in English or Spanish. OBJECTIVE: A review of longitudinal data on GARD inquiries from 2002 to 2016 and assessment of the results of two user satisfaction surveys were conducted to understand the demographics and needs of GARD customers over time...
May 25, 2017: Translational Science of Rare Diseases
https://www.readbyqxmd.com/read/29152326/development-of-a-communication-aid-for-explaining-hypertrophic-cardiomyopathy-genetic-test-results
#17
Yana Smagarinsky, Charlotte Burns, Catherine Spinks, Christopher Semsarian, Jodie Ingles
Background: Large gene panels are now commonplace for hypertrophic cardiomyopathy (HCM), increasing the yield of uncertain genetic findings. Few resources exist which aim to facilitate communication of HCM genetic test results. We sought to develop, pilot, and refine a communication aid for probands receiving HCM genetic test results. Methods: Development was a multi-step process involving expertise of a multidisciplinary team, literature review, and empirical experience...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29151969/overexpression-of-smoc2-attenuates-the-tumorigenicity-of-hepatocellular-carcinoma-cells-and-is-associated-with-a-positive-postoperative-prognosis-in-human-hepatocellular-carcinoma
#18
Xu-Qiong Huang, Zi-Qi Zhou, Xiao-Fei Zhang, Chang-Long Chen, Yan Tang, Qian Zhu, Jian-Hua Zhang, Jian-Chuan Xia
Secreted modular calcium binding protein-2 (SMOC2), a recently identified matricellular protein that belongs to the SPARC protein family, has been reported to be downregulated in various cancers. The purpose of this study was to investigate the clinical significance and biological function of SMOC2 in human hepatocellular carcinoma. Real-time quantitative PCR and western blotting analyses revealed that SMOC2 mRNA and protein levels were significantly downregulated in human HCC tissues compared to the matched adjacent normal tissues...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29151856/a-pedigree-based-experiment-reveals-variation-in-salinity-and%C3%A2-thermal-tolerance-in-the-salmon-louse-lepeophtheirus-salmonis
#19
Lina Eva Robin Ljungfeldt, María Quintela, François Besnier, Frank Nilsen, Kevin Alan Glover
The salmon louse is a highly abundant ectoparasitic copepod of salmonids in the North Pacific and Atlantic. Widespread and rapid development of resistance to chemical agents used to delouse salmonids on marine farms is now threatening the continued development of the aquaculture industry and have served as a potent catalyst for the development of alternative pest management strategies. These include freshwater and warm-water treatments to which the louse is sensitive. However, given the well-documented evolutionary capacity of this species, the risk of developing tolerance towards these environmental treatments cannot be dismissed...
December 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/29151655/assessing-parenting-and-family-functioning-measures-for-urban-american-indians
#20
Stephanie L Ayers, Stephen Kulis, Monica Tsethlikai
Urban American Indian (AI) families often "live in two worlds," and widely used parenting measures may not adequately capture their parenting styles. Drawing from baseline surveys of AI parents living in 3 urban communities in Arizona (n = 606), this study examines the applicability of using 6 previously validated measures with urban AI parents: parent self-agency, parental supervision, positive parenting practices, discipline, family cohesion, and parent-adolescent conflict. A 4-step factor analytic sequential procedure was employed, and results indicate the only measure remaining as a single factor is discipline...
March 2017: Journal of Community Psychology
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