Lijiao Zu, Xicheng Wang, Peng Liu, Jiwei Xie, Xuejun Zhang, Weiru Liu, Zhencheng Li, Shiqing Zhang, Kaiwei Li, Ambra Giannetti, Wei Bi, Francesco Chiavaioli, Lei Shi, Tuan Guo
As the population ages, the worldwide prevalence of Alzheimer's disease (AD) as the most common dementia in the elderly is increasing dramatically. However, a long-term challenge is to achieve rapid and accurate early diagnosis of AD by detecting hallmarks such as amyloid beta (Aβ42 ). Here, a multi-channel microfluidic-based plasmonic fiber-optic biosensing platform is established for simultaneous detection and differentiation of multiple AD biomarkers. The platform is based on a gold-coated, highly-tilted fiber Bragg grating (TFBG) and a custom-developed microfluidics...
March 20, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)