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https://www.readbyqxmd.com/read/28436169/plasma-concentrations-of-lipids-during-pregnancy-and-the-risk-of-gestational-diabetes-mellitus-a-longitudinal-study
#1
Wei Bao, Sharon Dar, Yeyi Zhu, Jing Wu, Shristi Rawal, Shanshan Li, Natalie L Weir, Michael Y Tsai, Cuilin Zhang
BACKGROUND: Abnormal lipid profiles have been associated with gestational diabetes mellitus (GDM), but studies with longitudinal measures of lipids throughout pregnancy are sparse. We aimed to characterize the longitudinal changes in lipid profiles throughout pregnancy and prospectively examine the associations of plasma lipid levels with risk of GDM. METHODS: This is a nested case-control study including 107 GDM cases and 214 matched non-GDM controls from participants in the NICHD Fetal Growth Studies-Singleton Cohort...
April 24, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28421703/foremost-prenatal-physician-scientist-tapped-to-lead-national-child-health-agency-diana-bianchi-md-is-focused-on-fostering-more-genomics-research-enabling-greater-data-sharing-collaboration-among-agencies-in-new-role-at-nichd
#2
https://www.readbyqxmd.com/read/28419085/neonatal-outcomes-of-moderatelyly-preterm-infants-compared-to-extremely-preterm-infants
#3
Michele C Walsh, Edward F Bell, Sarah Kandefer, Shampa Saha, Waldemar A Carlo, Carl T D'Angio, Abbot R Laptook, Pablo J Sanchez, Barbara J Stoll, Seetha Shankaran, Krisa P Van Meurs, Noah Cook, Rosemary D Higgins, Abhik Das, Nancy S Newman, Kurt Schibler, Barbara Schmidt, C Michael Cotten, Brenda B Poindexter, Kristi L Watterberg, William E Truog
BACKGROUND: Extremely preterm infants (EPT, <29 weeks' gestation) represent only 0.9% of births in the U.S., yet these infants are focus of most published research. Moderately preterm neonates (MPT, 29-33(6/7) weeks), are an understudied group of high-risk infants. METHODS: Objective: To determine the neonatal outcomes of MPT across the gestational age spectrum, and to compare these to EPT. A prospective observational cohort was formed in 18 Level 3-4 NICUs in the Eunice Kennedy Shriver NICHD Neonatal Research Network...
April 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28406655/heterogeneity-in-externalizing-problems-at-age-3-association-with-age-15-biological-and-environmental-outcomes
#4
Kostas A Fanti, Eva Kimonis
Investigating heterogeneity in antisocial behavior early in life is essential for understanding the etiology, development, prognosis, and treatment of these problems. Data from the longitudinal National Institute of Child Health and Development (NICHD) study of Early Child Care were used to identify homogeneous groups of young antisocial children differentiated on externalizing problems, internalizing problems, and callous-unemotional (CU) traits using latent profile analysis (LPA). We examined how identified subgroups were differentiated on adolescent social, biological, cognitive, and environmental outcomes, controlling for dispositional and contextual antecedents during the first 2 years of life...
April 13, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28403968/inter-observer-reliability-of-4-fetal-heart-rate-classifications
#5
C Garabedian, L Butruille, E Drumez, E Servan Schreiber, S Bartolo, G Bleu, V Mesdag, P Deruelle, J De Jonckheere, V Houfflin-Debarge
OBJECTIVE: Different classification of fetal heart rate (FHR) pattern have been proposed: FHR classified as either "reassuring" or "non-reassuring", the National Institute of Child Health and Human Development (NICHD) published in 2008 a 3-tier system, the French College of Gynecology and Obstetrics (CNGOF) recommended in 2013 a 5-tier system and recently in 2015, the Federation International of Gynecology and Obstetrics (FIGO) proposed a new classification based on a 3-tier system. Our objective was to assess the inter-observer reliability of these 4 existing classifications...
February 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28369278/cytomegalovirus-urinary-shedding-in-hiv-infected-pregnant-women-and-congenital-cytomegalovirus-infection
#6
Kristina Adachi, Jiahong Xu, Bonnie Ank, D Heather Watts, Lynne M Mofenson, Jose Henrique Pilotto, Esau Joao, Breno Santos, Rosana Fonseca, Regis Kreitchmann, Jorge Pinto, Marisa M Mussi-Pinhata, Glenda Gray, Gerhard Theron, Mariza G Morgado, Yvonne J Bryson, Valdilea G Veloso, Jeffrey D Klausner, Jack Moye, Karin Nielsen-Saines
Background: Cytomegalovirus (CMV) urinary shedding in HIV-infected pregnant women was evaluated to determine whether it poses an increased risk for congenital CMV infection (cCMV). Methods: A subset of mother-infant pairs enrolled in the perinatal NICHD HPTN 040 study (distinguished by no antiretroviral use before labor) was evaluated. Maternal and infant urines were tested by qualitative real-time polymerase chain reaction (RT-PCR) for CMV DNA with quantitative RT-PCR performed on positive specimens...
March 22, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28328243/factors-associated-with-bleeding-and-thrombosis-in-children-receiving-extracorporeal-membrane-oxygenation-ecmo
#7
Heidi J Dalton, Ron Reeder, Pamela Garcia-Filion, Richard Holubkov, Robert A Berg, Athena Zuppa, Frank W Moler, Thomas Shanley, Murray M Pollack, Christopher Newth, John Berger, David Wessel, Joseph Carcillo, Michael Bell, Sabrina Heidemann, Kathleen L Meert, Richard Harrison, Allan Doctor, Robert F Tamburro, J Michael Dean, Tammara Jenkins, Carol Nicholson
RATIONALE: Extracorporeal membrane oxygenation (ECMO) is employed for respiratory and cardiac failure in children but is complicated by bleeding and thrombosis. OBJECTIVES: (1) Measure the incidence of bleeding (blood loss requiring transfusion or intracranial hemorrhage) and thrombosis during ECMO support; (2) identify factors associated with these complications; and (3) determine the impact of these complications on patient outcome. METHODS: Prospective, observational cohort study in pediatric, cardiac, and neonatal intensive care units in eight hospitals from December 2012 to September 2014...
March 22, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28326963/the-stillbirth-classification-system-for-the-safe-passage-study
#8
Theonia K Boyd, Colleen A Wright, Hein J Odendaal, Amy J Elliott, Mary Ann Sens, Rebecca D Folkerth, Drucilla J Roberts, Hannah C Kinney
Objective Describe the classification system for assigning the cause of stillbirth in the Safe Passage Study, an international, multi-institutional, prospective analysis conducted by the NIAAA/NICHD-funded Prenatal Alcohol in SIDS and Stillbirth (PASS) Research Network. The study mission is to determine the role of prenatal alcohol and/or cigarette smoke exposure in adverse pregnancy outcomes, including stillbirth, in a high-risk cohort of 12,000 maternal/fetal dyads. Methods The PASS Network classification system is based upon 5 "sites of origin" for cause of stillbirth, further subdivided into mechanism subcategories; both are employed to assign an ultimate cause of death...
March 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28318284/why-classroom-climate-matters-for-children-high-in-anxious-solitude-a-study-of-differential-susceptibility
#9
Kathleen Hughes, Robert J Coplan
The goal of the current study was to examine the complex links among anxious solitude, classroom climate, engagement, achievement, and gender. In particular, drawing upon the differential susceptibility hypothesis (Belsky, 1997), we investigated if children high in anxious solitude were particularly sensitive and responsive to the classroom environment. Participants were N = 712 children in Grade 3, drawn from the National Institute of Child and Human Development (NICHD) Study of Early Child Care and Youth Development data set...
March 20, 2017: School Psychology Quarterly
https://www.readbyqxmd.com/read/28263750/maternal-stress-and-neonatal-anthropometry-the-nichd-fetal-growth-studies
#10
Deborah A Wing, Ana M Ortega-Villa, William A Grobman, Mary L Hediger, Jagteshwar Grewal, Sarah J Pugh, Sungduk Kim, Roger Newman, Ed Chien, John Owen, Mary E D'Alton, Ronald Wapner, Anthony Sciscione, Paul S Albert, Katherine L Grantz
BACKGROUND: The effect of maternal mood disorders on neonatal measurements is not well-defined. The Fetal Growth Studies-Singletons provide a unique opportunity to evaluate the relationship between perceived maternal stress and neonatal growth measurements. OBJECTIVE: The purpose of this study was to determine whether perceived maternal stress during pregnancy is associated with anthropometric measurements in the neonate. STUDY DESIGN: This analysis was based on a prospective, multicenter longitudinal study of fetal growth...
March 3, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28254688/sexual-abuse-and-preschoolers-forensic-details-in-regard-of-question-types
#11
Karine Gagnon, Mireille Cyr
The present study looks into the association between the types of questions used by interviewers and the number of details obtained among preschoolers during an investigative interview. An innovative aspect of this study concerns the analysis of question subtypes (eg. open-ended directive and closed-ended). Analysis of variance were carried out on 55 NICHD interview protocols conducted among children aged three to five years old who disclosed an episode of sexual abuse. Findings reveal that interviewers' style is in accordance with best practices in conducting investigative interviews with children allegedly victims of sexual abuse...
February 27, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28209489/the-systematic-error-in-the-estimation-of-fetal%C3%A2-weight-and-the-underestimation-of-fetal-growth-restriction
#12
Justin R Lappen, Stephen A Myers
Fetal growth restriction (FGR) is associated with an increased risk of perinatal morbidity and mortality and has lifetime implications for the risk of chronic medical conditions. Antenatal diagnosis of FGR remains poor, with the majority of cases remaining undiagnosed. Although several factors contribute to the underdiagnosis of FGR, the error in ultrasound estimation of fetal weight (EFW) generally is not considered in clinical practice. In this commentary, we suggest that the intrinsic, or systematic, error in ultrasound EFW is a significant factor contributing to the underestimation of fetuses predicted to have FGR and should be incorporated into screening and surveillance recommendations...
February 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28142152/improving-safe-and-effective-use-of-drugs-in-pregnancy-and-lactation-workshop-summary
#13
Laura E Riley, Alison G Cahill, Richard Beigi, Renate Savich, George Saade
In February 2015, given high rates of use of medications by pregnant women and the relative lack of data on safety and efficacy of many drugs utilized in pregnancy, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the Society for Maternal-Fetal Medicine (SMFM), the American College of Obstetricians and Gynecologists (ACOG), and the American Academy of Pediatrics (AAP) convened a group of experts to review the "current" state of the clinical care and science regarding medication use during the perinatal period...
January 31, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28140723/placenta-previa-and-maternal-hemorrhagic-morbidity
#14
Karen J Gibbins, Brett D Einerson, Michael W Varner, Robert M Silver
OBJECTIVE: Placenta previa is associated with maternal hemorrhage, but most literature focuses on morbidity in the setting of placenta accreta. We aim to characterize maternal morbidity associated with previa and to define risk factors for hemorrhage. METHODS: This is a secondary cohort analysis of the NICHD Maternal-Fetal Medicine Units Network Cesarean Section Registry. This analysis included all women undergoing primary Cesarean delivery without placenta accreta...
February 21, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28139890/pharmacogenomics-of-17-alpha-hydroxyprogesterone-caproate-for-recurrent-preterm-birth-a-case-control-study
#15
T A Manuck, W S Watkins, M S Esplin, J Biggio, R Bukowski, S Parry, H Zhan, H Huang, W Andrews, G Saade, Y Sadovsky, U M Reddy, J Ilekis, M Yandell, M W Varner, L B Jorde
OBJECTIVE: To compare maternal genotypes between women with and without significant prolongation of pregnancy in the setting of 17-alpha hydroxyprogesterone caproate (17-P) administration for the prevention of recurrent preterm birth (PTB). DESIGN: Case-control. SETTING: Three tertiary-care centres across the USA. POPULATION: Women (n = 99) with ≥ 1 prior singleton spontaneous PTB, receiving 17-P. METHODS: Women were classified as having successful prolongation of pregnancy during the 17-P treated pregnancy, in two ways: (1) Definition A: success/non-success based on difference in gestational age at delivery between 17-P-treated and untreated pregnancies (success: delivered ≥ 3 weeks later with 17-P) and (2) Definition B: success/non-success based on reaching term (success: delivered at term with 17-P)...
January 31, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28090255/clinical-utility-of-echocardiography-for-the-diagnosis-and-prognosis-in-children-with-bronchopulmonary-dsyplasia
#16
Young Earl Choi, Hwa Jin Cho, Eun Song Song, In Seok Jeong, Namsik Yoon, Young Youn Choi, Jae Sook Ma, Young Kuk Cho
BACKGROUND: Bronchopulmonary dysplasia (BPD) may result in chronic pulmonary artery hypertension and right ventricular (RV) dysfunction. Various echocardiographic assessments of RV dysfunction have been used to determine whether echocardiographic measurements of premature infants with BPD could provide sensitive measures of RV function that correlates with BPD severity. METHODS: Twenty-eight control subjects without BPD (non BPD group), 28 patients with mild BPD, 11 patients with moderate BPD, and six patients with severe BPD underwent echocardiograms with standard measurement such as ejection fraction by M-mode, tricuspid regurgitation pressure gradient, myocardial performance index (MPI) derived from pulse Doppler, and tissue Doppler imaging (TDI) measurements...
December 2016: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28079773/pregnancies-after-the-diagnosis-of-mild-gestational-diabetes-mellitus-and-risk-of-cardiometabolic-disorders
#17
Michael W Varner, Madeline Murguia Rice, Mark B Landon, Brian M Casey, Uma M Reddy, Ronald J Wapner, Dwight J Rouse, Alan T N Tita, John M Thorp, Edward K Chien, George R Saade, Alan M Peaceman, Sean C Blackwell, J Peter Vandorsten
OBJECTIVE: To assess the association of subsequent pregnancy with subsequent metabolic syndrome and type II diabetes mellitus after a pregnancy complicated by mild gestational diabetes mellitus (GDM). METHODS: We conducted a prospective observational follow-up study of women with mild GDM randomized from 2002 to 2007 to usual care or dietary intervention and glucose self-monitoring. Women were evaluated 5-10 years after the parent study. Participants were grouped according to the number of subsequent pregnancies (group A, none [reference]; group B, one; group C, two or greater)...
February 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28028203/development-of-a-pediatric-adverse-events-terminology
#18
Debbie S Gipson, Eric S Kirkendall, Brenda Gumbs-Petty, Theresa Quinn, A Steen, Amanda Hicks, Ann McMahon, Savian Nicholas, Anna Zhao-Wong, Perdita Taylor-Zapata, Mark Turner, Emily Herreshoff, Charlotte Jones, Jonathan M Davis, Margaret Haber, Steven Hirschfeld
In 2009, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) established the Pediatric Terminology Harmonization Initiative to establish a core library of terms to facilitate the acquisition and sharing of knowledge between pediatric clinical research, practice, and safety reporting. A coalition of partners established a Pediatric Terminology Adverse Event Working Group in 2013 to develop a specific terminology relevant to international pediatric adverse event (AE) reporting...
January 2017: Pediatrics
https://www.readbyqxmd.com/read/27999526/cme-cne-article-a-framework-of-care-in-multiple-sclerosis-part-1-updated-disease-classification-and-disease-modifying-therapy-use-in-specific-circumstances
#19
Scott D Newsome, Philip J Aliotta, Jacquelyn Bainbridge, Susan E Bennett, Gary Cutter, Kaylan Fenton, Fred Lublin, Dorothy Northrop, David Rintell, Bryan D Walker, Megan Weigel, Kathleen Zackowski, David E Jones
Activity Available Online: To access the article, post-test, and evaluation online, go to http://www.cmscscholar.org. TARGET AUDIENCE: The target audience for this activity is physicians, physician assistants, nursing professionals, and other health-care providers involved in the management of patients with multiple sclerosis (MS). LEARNING OBJECTIVES: Apply new information about MS to a comprehensive individualized treatment plan for patients with MSIntegrate the team approach into long-term planning in order to optimize rehabilitation care of patients with MSAccreditation Statement: This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Consortium of Multiple Sclerosis Centers (CMSC), Nurse Practitioner Alternatives (NPA), and Delaware Media Group...
November 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27960173/fetal-heart-rate-variability-validation-of-a-new-continuous-noninvasive-computerized-analysis
#20
Charles Garabedian, Laura Butruille, Elie Servan-Schreiber, Grégoire Ficheur, Laurent Storme, Philippe Deruelle, Julien De Jonckheere, Véronique Houfflin-Debarge
OBJECTIVE: We developed a computerized heart-rate variability index related to the fetal parasympathetic activity: the Fetal Stress Index (FSI). The objective was to determine whether the FSI is related to the visual analysis of the fetal heart rate (FHR). METHODS: Thirty tracings recorded at a labor ward were classified according to the NICHD categories: (I) normal FHR tracing, (II) intermediate risk of acidosis, and (III) high risk. FSI was calculated as minimum, maximum, and mean, and was evaluated before the onset of the FHR pattern, during the 10 min following, and between 10 and 20 min after that...
December 14, 2016: Gynecologic and Obstetric Investigation
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