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https://www.readbyqxmd.com/read/29767754/mid-luteal-progesterone-a-marker-of-treatment-outcomes-in-couples-with-unexplained-infertility
#1
Karl R Hansen, Esther Eisenberg, Valerie Baker, Micah J Hill, Sixia Chen, Sara Talken, Michael P Diamond, Richard S Legro, Christos Coutifaris, Ruben Alvero, Randal D Robinson, Peter Casson, Gregory M Christman, Nanette Santoro, Heping Zhang, Robert A Wild
Context: Adequate luteal phase progesterone exposure is necessary to induce endometrial changes required for a successful pregnancy outcome. The relationship between low mid-luteal progesterone concentration and the outcome of live birth in ovarian stimulation with intrauterine insemination (OS-IUI) treatments is not defined. Objective: To determine the level of mid-luteal progesterone portending a low chance of live birth following OS-IUI in couples with unexplained infertility...
May 14, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29750766/infectious-morbidity-mortality-and-nutrition-in-hiv-exposed-uninfected-formula-fed-infants-results-from-the-hptn-040-pactg-1043-trial
#2
Nava Yeganeh, D Heather Watts, Jiahong Xu, Tara Kerin, Esau C Joao, Jose Henrique Pilotto, Gerhard Theron, Glenda Gray, Breno Santos, Rosana Fonseca, Regis Kreitchmann, Jorge Pinto, Marisa M Mussi-Pinhata, Valdilea Veloso, Margaret Camarca, Lynne Mofenson, Jack Moye, Karin Nielsen-Saines
BACKGROUND: HIV exposed uninfected (HEU) infants are a growing population with potentially poor health outcomes. We evaluated morbidity and mortality in HEU formula-fed infants enrolled in the NICHD HPTN 040/PACTG 1043 trial. METHODS: Infectious morbidity, mortality, and undernutrition were evaluated within a cohort of 1,000 HEU infants enrolled between 4/2004 and 4/2010 in Brazil (N=766) and South Africa (N=234) as part of the NICHD/HPTN 040 trial of three different antiretroviral regimens to decrease intrapartum HIV vertical transmission...
May 10, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29749256/an-sem-assessment-of-the-internal-structure-and-predictive-validity-of-the-abbreviated-early-adolescent-home-inventory
#3
Samuel B Green, Amy L Pennar, Robert H Bradley
The Home Observation for Measurement of the Environment (HOME) Inventory is designed to assess the quality and quantity of support, stimulation, and structure provided to children in the home environment. HOME has been widely used for research and applied purposes. We focused on an abbreviated version of the Early Adolescent HOME (EA-HOME-A) that was administered to 15-year-old adolescents and their parents ( N = 958) as part of the NICHD (National Institute of Child Health and Human Development) Study of Early Child Care and Youth Development...
May 1, 2018: Assessment
https://www.readbyqxmd.com/read/29743661/bronchopulmonary-dysplasia-effect-of-altitude-correction-and-role-for-the-neonatal-research-network-prediction-algorithm
#4
Kristina Gulliver, Bradley A Yoder
OBJECTIVE: To determine the effect of altitude correction on bronchopulmonary dysplasia (BPD) rates and to assess validity of the NICHD "Neonatal BPD Outcome Estimator" for predicting BPD with and without altitude correction. SUBJECTS: Retrospective analysis included neonates born <30 weeks gestational age (GA) between 2010 and 2016. "Effective" FiO2 requirements were determined at 36 weeks corrected GA. Altitude correction performed via ratio of barometric pressure (BP) in our unit to sea level BP...
May 9, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29742665/variation-in-the-nulliparous-term-singleton-vertex-cesarean-delivery-rate
#5
Daniel N Pasko, Paula McGee, William A Grobman, Jennifer L Bailit, Uma M Reddy, Ronald J Wapner, Michael W Varner, John M Thorp, Kenneth J Leveno, Steve N Caritis, Mona Prasad, George Saade, Yoram Sorokin, Dwight J Rouse, Sean C Blackwell, Jorge E Tolosa
OBJECTIVE: To estimate the contributions of patient and health care provider-hospital characteristics to the variation in the frequency of nulliparous, term, singleton, vertex cesarean delivery in a multi-institutional U.S. cohort. METHODS: We performed a secondary analysis of the multicenter Assessment of Perinatal Excellence cohort of 115,502 mother and neonatal pairs who were delivered at 25 hospitals between March 2008 and February 2011. Women met inclusion criteria if they were nulliparous and delivered a singleton in vertex presentation at term...
May 7, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29741802/deviant-peer-behavior-and-adolescent-delinquency-protective-effects-of-inhibitory-control-planning-or-decision-making
#6
J Benjamin Hinnant, Alissa B Forman-Alberti
We examined relations between adolescent perceptions of deviant peer behavior and delinquency as moderated by inhibitory control, planning, and decision making in the National Institute of Child Health and Human Development (NICHD) Study of Early Child Care and Youth Development at age 15 (N = 991). Adolescents reported perceptions of deviant peer behavior. Inhibitory control, planning, and decision making were assessed behaviorally. Delinquency was evaluated with a latent variable comprised of parent-guardian perceptions of adolescent delinquency and adolescent self-reports...
May 9, 2018: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/29740100/genetic-and-environmental-influences-on-fetal-growth-vary-during-sensitive-periods-in-pregnancy
#7
Tsegaselassie Workalemahu, Katherine L Grantz, Jagteshwar Grewal, Cuilin Zhang, Germaine M Buck Louis, Fasil Tekola-Ayele
Aberrant fetal growth is associated with morbidities and mortality during childhood and adult life. Although genetic and environmental factors are known to influence in utero growth, their relative contributions over pregnancy is unknown. We estimated, across gestation, the genetic heritability, contribution of shared environment, and genetic correlations of fetal growth measures (abdominal circumference (AC), humerus length (HL), femur length (FL), and estimated fetal weight (EFW)) in a prospective cohort of dichorionic twin gestations recruited through the NICHD Fetal Growth Studies...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29697998/income-gains-predict-cognitive-functioning-longitudinally-throughout-later-childhood-in-poor-children
#8
Laurel Raffington, John J Prindle, Yee Lee Shing
Alleviating disadvantage in low-income environments predicts higher cognitive abilities during early childhood. It is less established whether family income continues to predict cognitive growth in later childhood or whether there may even be bidirectional dynamics. Notably, living in poverty may moderate income-cognition dynamics. In this study, we investigated longitudinal dynamics over 7 waves of data collection from 1,168 children between the ages of 4.6 and 12 years, 226 (19%) of whom lived in poverty in at least 1 wave, as part of the NICHD Study of Early Child Care and Youth Development...
April 26, 2018: Developmental Psychology
https://www.readbyqxmd.com/read/29697996/bidirectional-effects-between-parenting-sensitivity-and-child-behavior-a-cross-lagged-analysis-across-middle-childhood-and-adolescence
#9
Bharathi J Zvara, Kelly W Sheppard, Martha Cox
Using a longitudinal, cross-lagged design, this study examined the bidirectional relations between mothers' and fathers' sensitivity and children's externalizing (EXT) and internalizing (INT) behavior from middle childhood into adolescence. The subsample comprised families (N = 578) in which the mother and father cohabitated from the study's first time point (child age = 54 months) through Age 15 in the longitudinal NICHD Study of Early Child Care and Youth Development. Study results revealed differential patterns for mother-child and father-child relations in the full sample and separately for males and females...
April 26, 2018: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/29687638/tracheal-aspirate-vegf-and-sphingolipid-metabolites-in-the-preterm-infant-with-later-development-of-bronchopulmonary-dysplasia
#10
Karen D Hendricks-Muñoz, Jie Xu, Judith A Voynow
OBJECTIVE: Vascular endothelial growth factor (VEGF) and sphingolipid metabolites, sphingosine 1-phosphate (S1P), and ceramides are important to lung development and repair. We hypothesized specific sphingolipid and VEGF alterations would be associated with BPD development and aimed to investigate the early tracheal aspirate (TA) VEGF and S1P relationship with later diagnosis of preterm infant bronchopulmonary dysplasia, BPD. DESIGN: TA VEGF and lipidomics were measured in TA from Infants <32 weeks gestational age at birth with and without later BPD...
April 23, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29677302/effect-of-uterosacral-ligament-suspension-vs-sacrospinous-ligament-fixation-with-or-without-perioperative-behavioral-therapy-for-pelvic-organ-vaginal-prolapse-on-surgical-outcomes-and-prolapse-symptoms-at-5-years-in-the-optimal-randomized-clinical-trial
#11
RANDOMIZED CONTROLLED TRIAL
J Eric Jelovsek, Matthew D Barber, Linda Brubaker, Peggy Norton, Marie Gantz, Holly E Richter, Alison Weidner, Shawn Menefee, Joseph Schaffer, Norma Pugh, Susan Meikle
Importance: Uterosacral ligament suspension (ULS) and sacrospinous ligament fixation (SSLF) are commonly performed pelvic organ prolapse procedures despite a lack of long-term efficacy data. Objective: To compare outcomes in women randomized to (1) ULS or SSLF and (2) usual care or perioperative behavioral therapy and pelvic floor muscle training (BPMT) for vaginal apical prolapse. Design, Setting, and Participants: This 2 × 2 factorial randomized clinical trial was conducted at 9 US medical centers...
April 17, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29668891/maternal-polycystic-ovarian-syndrome-and-early-offspring-development
#12
Griffith A Bell, Rajeshwari Sundaram, Sunni L Mumford, Hyojun Park, James Mills, Erin M Bell, Miranda Broadney, Edwina H Yeung
STUDY QUESTION: Is maternal polycystic ovarian syndrome (PCOS) associated with developmental delays in offspring? SUMMARY ANSWER: Offspring of mothers with PCOS were at higher risk of failure on the Ages and Stages Questionnaire (ASQ). WHAT IS KNOWN ALREADY: There is growing evidence that offspring of mothers with PCOS may be at higher risk for developmental disorders due to potential exposure to hyperandrogenism and insulin resistance. Few studies exist regarding maternal PCOS and early childhood development in the USA...
April 13, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29557977/dash-the-data-and-specimen-hub-of-the-national-institute-of-child-health-and-human-development
#13
Rohan Hazra, Susan Tenney, Alexandra Shlionskaya, Rajni Samavedam, Kristin Baxter, John Ilekis, Jennifer Weck, Marian Willinger, Gilman Grave, Katerina Tsilou, David Songco
The benefits of data sharing are well-established and an increasing number of policies require that data be shared upon publication of the main study findings. As data sharing becomes the new norm, there is a heightened need for additional resources to drive efficient data reuse. This article describes the development and implementation of the Data and Specimen Hub (DASH) by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) to promote data sharing from NICHD-funded studies and enable researchers to comply with NIH data sharing policies...
March 20, 2018: Scientific Data
https://www.readbyqxmd.com/read/29551313/usefulness-of-an-online-risk-estimator-for-bronchopulmonary-dysplasia-in-predicting-corticosteroid-treatment-in-infants-born-preterm
#14
Alain Cuna, Cynthia Liu, Shree Govindarajan, Margaret Queen, Hongying Dai, William E Truog
OBJECTIVE: To assess the usefulness of a bronchopulmonary dysplasia (BPD) outcome estimator developed by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) in identifying high-risk preterm infants treated with steroids. STUDY DESIGN: This was a single-center retrospective study of infants born ≤30 weeks of gestational age. The NICHD BPD outcome estimator was used to retrospectively calculate BPD risk at various postnatal ages...
March 15, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29531406/pattern-mixture-models-with-incomplete-informative-cluster-size-application-to-a-repeated-pregnancy-study
#15
Ashok Chaurasia, Danping Liu, Paul S Albert
The incomplete informative cluster size problem is motivated by the NICHD Consecutive Pregnancies Study, aiming to study the relationship between pregnancy outcomes and parity. These pregnancy outcomes are potentially associated with the number of births over a woman's lifetime, resulting in an incomplete informative cluster size (censored at the end of the study window). We develop a pattern mixture model for informative cluster size by treating the lifetime number of births as a latent variable. We compare this approach with a simple alternative method that approximates the pattern mixture model...
January 2018: Journal of the Royal Statistical Society. Series C, Applied Statistics
https://www.readbyqxmd.com/read/29528912/congenital-cmv-and-hiv-perinatal-transmission
#16
Kristina Adachi, Jiahong Xu, Bonnie Ank, D Heather Watts, Margaret Camarca, Lynne M Mofenson, Jose Henrique Pilotto, Esau Joao, Glenda Gray, Gerhard Theron, Breno Santos, Rosana Fonseca, Regis Kreitchmann, Jorge Pinto, Marisa M Mussi-Pinhata, Daisy Maria Machado, Mariana Ceriotto, Mariza G Morgado, Yvonne J Bryson, Valdilea G Veloso, Beatriz Grinsztejn, Mark Mirochnick, Jack Moye, Karin Nielsen-Saines
BACKGROUND: Congenital cytomegalovirus (CMV) infection (cCMV) is an important cause of hearing loss and cognitive impairment. Prior studies suggest that HIV-exposed children are at higher risk of acquiring cCMV. We assessed the presence, magnitude, and risk factors associated with cCMV among infants born to HIV-infected women, who were not receiving antiretrovirals during pregnancy. METHODS: cCMV and urinary CMV load were determined in a cohort of infants born to HIV-infected women not receiving antiretrovirals during pregnancy...
March 9, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29524590/evaluation-validation-and-refinement-of-noninvasive-diagnostic-biomarkers-for-endometriosis-endomarker-a-protocol-to-phenotype-bio-specimens-for-discovery-and-validation
#17
Kurt Barnhart, Linda Giudice, Steve Young, Tracey Thomas, Michael P Diamond, James Segars, Wahid A Youssef, Stephen Krawetz, Nanette Santoro, Esther Eisenberg, Heping Zhang
OBJECTIVE: Endometriosis is a chronic, estrogen dependent condition that affects 5-10% of reproductive aged women and is associated with pelvic pain and infertility. As the approach to therapy shifts from surgical ablation to pharmacological control, a non-surgical mode of diagnosis would be desirable. The ENDOmarker study was designed by the NICHD Reproductive Medicine Network (RMN) to obtain well characterized and phenotyped bio specimens in a standardized fashion from women with and without endometriosis...
May 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29479231/initiation-of-passive-cooling-at-referring-centre-is-most-predictive-of-achieving-early-therapeutic-hypothermia-in-asphyxiated-newborns
#18
Brigitte Lemyre, Linh Ly, Vann Chau, Anil Chacko, Nicholas Barrowman, Hilary Whyte, Steven P Miller
Objective: To identify factors associated with early initiation and achievement of therapeutic hypothermia (TH) in newborns with hypoxic-ischemic encephalopathy (HIE). Methods: Retrospective cohort study of newborns who received TH according to National Institute of Child Health and Human Development (NICHD) criteria in two academic level 3 Neonatal Intensive Care Units (NICU) between 2009 and 2013. All infants were transported by a neonatal transport team (NNTT)...
August 2017: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29468711/estimating-recurrence-and-incidence-of-preterm-birth-subject-to-measurement-error-in-gestational-age-a-hidden-markov-modeling-approach
#19
Paul S Albert
Prediction of preterm birth as well as characterizing the etiological factors affecting both the recurrence and incidence of preterm birth (defined as gestational age at birth ≤ 37 wk) are important problems in obstetrics. The National Institute of Child Health and Human Development (NICHD) consecutive pregnancy study recently examined this question by collecting data on a cohort of women with at least 2 pregnancies over a fixed time interval. Unfortunately, measurement error due to the dating of conception may induce sizable error in computing gestational age at birth...
May 30, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29422207/a-new-customized-fetal-growth-standard-for-african-american-women-the-prb-nichd-detroit-study
#20
Adi L Tarca, Roberto Romero, Dereje W Gudicha, Offer Erez, Edgar Hernandez-Andrade, Lami Yeo, Gaurav Bhatti, Percy Pacora, Eli Maymon, Sonia S Hassan
BACKGROUND: The assessment of fetal growth disorders requires a standard. Current nomograms for the assessment of fetal growth in African American women have been derived either from neonatal (rather than fetal) biometry data or have not been customized for maternal ethnicity, weight, height, and parity and fetal sex. OBJECTIVE: We sought to (1) develop a new customized fetal growth standard for African American mothers; and (2) compare such a standard to 3 existing standards for the classification of fetuses as small (SGA) or large (LGA) for gestational age...
February 2018: American Journal of Obstetrics and Gynecology
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