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https://www.readbyqxmd.com/read/28209489/the-systematic-error-in-the-estimation-of-fetal-weight-and-the-underestimation-of-fetal-growth-restriction
#1
Justin R Lappen, Stephen A Myers
Fetal growth restriction (FGR) is associated with an increased risk of perinatal morbidity and mortality and has lifetime implications for the risk of chronic medical conditions. Antenatal diagnosis of fetal growth restriction (FGR) remains poor with the majority of cases remaining undiagnosed. While several factors contribute to the underdiagnosis of FGR, the error in ultrasound estimation of fetal weight (EFW) is generally not considered in clinical practice. In this commentary, we suggest that the intrinsic, or systematic, error in ultrasound EFW is a significant factor contributing to the underestimation of fetuses predicted to have FGR and should be incorporated into screening and surveillance recommendations...
February 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28142152/improving-safe-and-effective-use-of-drugs-in-pregnancy-and-lactation-workshop-summary
#2
Laura E Riley, Alison G Cahill, Richard Beigi, Renate Savich, George Saade
In February 2015, given high rates of use of medications by pregnant women and the relative lack of data on safety and efficacy of many drugs utilized in pregnancy, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the Society for Maternal-Fetal Medicine (SMFM), the American College of Obstetricians and Gynecologists (ACOG), and the American Academy of Pediatrics (AAP) convened a group of experts to review the "current" state of the clinical care and science regarding medication use during the perinatal period...
January 31, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28140723/placenta-previa-and-maternal-hemorrhagic-morbidity
#3
Karen J Gibbins, Brett D Einerson, Michael W Varner, Robert M Silver
OBJECTIVE: Placenta previa is associated with maternal hemorrhage, but most literature focuses on morbidity in the setting of placenta accreta. We aim to characterize maternal morbidity associated with previa and to define risk factors for hemorrhage. METHODS: This is a secondary cohort analysis of the NICHD Maternal-Fetal Medicine Units Network Cesarean Section Registry. This analysis included all women undergoing primary Cesarean delivery without placenta accreta...
January 31, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28139890/pharmacogenomics-of-17-alpha-hydroxyprogesterone-caproate-for-recurrent-preterm-birth-a-case-control-study
#4
T A Manuck, W S Watkins, M S Esplin, J Biggio, R Bukowski, S Parry, H Zhan, H Huang, W Andrews, G Saade, Y Sadovsky, U M Reddy, J Ilekis, M Yandell, M W Varner, L B Jorde
OBJECTIVE: To compare maternal genotypes between women with and without significant prolongation of pregnancy in the setting of 17-alpha hydroxyprogesterone caproate (17-P) administration for the prevention of recurrent preterm birth (PTB). DESIGN: Case-control. SETTING: Three tertiary-care centres across the USA. POPULATION: Women (n = 99) with ≥ 1 prior singleton spontaneous PTB, receiving 17-P. METHODS: Women were classified as having successful prolongation of pregnancy during the 17-P treated pregnancy, in two ways: (1) Definition A: success/non-success based on difference in gestational age at delivery between 17-P-treated and untreated pregnancies (success: delivered ≥ 3 weeks later with 17-P) and (2) Definition B: success/non-success based on reaching term (success: delivered at term with 17-P)...
January 31, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28090255/clinical-utility-of-echocardiography-for-the-diagnosis-and-prognosis-in-children-with-bronchopulmonary-dsyplasia
#5
Young Earl Choi, Hwa Jin Cho, Eun Song Song, In Seok Jeong, Namsik Yoon, Young Youn Choi, Jae Sook Ma, Young Kuk Cho
BACKGROUND: Bronchopulmonary dysplasia (BPD) may result in chronic pulmonary artery hypertension and right ventricular (RV) dysfunction. Various echocardiographic assessments of RV dysfunction have been used to determine whether echocardiographic measurements of premature infants with BPD could provide sensitive measures of RV function that correlates with BPD severity. METHODS: Twenty-eight control subjects without BPD (non BPD group), 28 patients with mild BPD, 11 patients with moderate BPD, and six patients with severe BPD underwent echocardiograms with standard measurement such as ejection fraction by M-mode, tricuspid regurgitation pressure gradient, myocardial performance index (MPI) derived from pulse Doppler, and tissue Doppler imaging (TDI) measurements...
December 2016: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28079773/pregnancies-after-the-diagnosis-of-mild-gestational-diabetes-mellitus-and-risk-of-cardiometabolic-disorders
#6
Michael W Varner, Madeline Murguia Rice, Mark B Landon, Brian M Casey, Uma M Reddy, Ronald J Wapner, Dwight J Rouse, Alan T N Tita, John M Thorp, Edward K Chien, George R Saade, Alan M Peaceman, Sean C Blackwell, J Peter Vandorsten
OBJECTIVE: To assess the association of subsequent pregnancy with subsequent metabolic syndrome and type II diabetes mellitus after a pregnancy complicated by mild gestational diabetes mellitus (GDM). METHODS: We conducted a prospective observational follow-up study of women with mild GDM randomized from 2002 to 2007 to usual care or dietary intervention and glucose self-monitoring. Women were evaluated 5-10 years after the parent study. Participants were grouped according to the number of subsequent pregnancies (group A, none [reference]; group B, one; group C, two or greater)...
February 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28028203/development-of-a-pediatric-adverse-events-terminology
#7
Debbie S Gipson, Eric S Kirkendall, Brenda Gumbs-Petty, Theresa Quinn, A Steen, Amanda Hicks, Ann McMahon, Savian Nicholas, Anna Zhao-Wong, Perdita Taylor-Zapata, Mark Turner, Emily Herreshoff, Charlotte Jones, Jonathan M Davis, Margaret Haber, Steven Hirschfeld
In 2009, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) established the Pediatric Terminology Harmonization Initiative to establish a core library of terms to facilitate the acquisition and sharing of knowledge between pediatric clinical research, practice, and safety reporting. A coalition of partners established a Pediatric Terminology Adverse Event Working Group in 2013 to develop a specific terminology relevant to international pediatric adverse event (AE) reporting...
January 2017: Pediatrics
https://www.readbyqxmd.com/read/27999526/cme-cne-article-a-framework-of-care-in-multiple-sclerosis-part-1-updated-disease-classification-and-disease-modifying-therapy-use-in-specific-circumstances
#8
Scott D Newsome, Philip J Aliotta, Jacquelyn Bainbridge, Susan E Bennett, Gary Cutter, Kaylan Fenton, Fred Lublin, Dorothy Northrop, David Rintell, Bryan D Walker, Megan Weigel, Kathleen Zackowski, David E Jones
: Activity Available Online: To access the article, post-test, and evaluation online, go to http://www.cmscscholar.org. TARGET AUDIENCE: The target audience for this activity is physicians, physician assistants, nursing professionals, and other health-care providers involved in the management of patients with multiple sclerosis (MS). LEARNING OBJECTIVES: Apply new information about MS to a comprehensive individualized treatment plan for patients with MSIntegrate the team approach into long-term planning in order to optimize rehabilitation care of patients with MSAccreditation Statement: This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Consortium of Multiple Sclerosis Centers (CMSC), Nurse Practitioner Alternatives (NPA), and Delaware Media Group...
November 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27960173/fetal-heart-rate-variability-validation-of-a-new-continuous-noninvasive-computerized-analysis
#9
Charles Garabedian, Laura Butruille, Elie Servan-Schreiber, Grégoire Ficheur, Laurent Storme, Philippe Deruelle, Julien De Jonckheere, Véronique Houfflin-Debarge
OBJECTIVE: We developed a computerized heart-rate variability index related to the fetal parasympathetic activity: the Fetal Stress Index (FSI). The objective was to determine whether the FSI is related to the visual analysis of the fetal heart rate (FHR). METHODS: Thirty tracings recorded at a labor ward were classified according to the NICHD categories: (I) normal FHR tracing, (II) intermediate risk of acidosis, and (III) high risk. FSI was calculated as minimum, maximum, and mean, and was evaluated before the onset of the FHR pattern, during the 10 min following, and between 10 and 20 min after that...
December 14, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27939328/a-longitudinal-study-of-sleep-duration-in-pregnancy-and-subsequent-risk-of-gestational-diabetes-findings-from-a-prospective-multiracial-cohort
#10
Shristi Rawal, Stefanie N Hinkle, Yeyi Zhu, Paul S Albert, Cuilin Zhang
BACKGROUND: Both short and prolonged sleep duration have been linked to impaired glucose metabolism. Sleep patterns change during pregnancy, but prospective data are limited on their relation to gestational diabetes. OBJECTIVE: We sought to prospectively examine the trimester-specific (first and second trimester) association between typical sleep duration in pregnancy and subsequent risk of gestational diabetes, as well as the influence of compensatory daytime napping on this association...
December 9, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27875999/helping-babies-breathe-hbb-training-what-happens-to-knowledge-and-skills-over-time
#11
Akash Bang, Archana Patel, Roopa Bellad, Peter Gisore, Shivaprasad S Goudar, Fabian Esamai, Edward A Liechty, Sreelatha Meleth, Norman Goco, Susan Niermeyer, William Keenan, Beena D Kamath-Rayne, George A Little, Susan B Clarke, Victoria A Flanagan, Sherri Bucher, Manish Jain, Nilofer Mujawar, Vinita Jain, Janet Rukunga, Niranjana Mahantshetti, Sangappa Dhaded, Manisha Bhandankar, Elizabeth M McClure, Waldemar A Carlo, Linda L Wright, Patricia L Hibberd
BACKGROUND: The first minutes after birth are critical to reducing neonatal mortality. Helping Babies Breathe (HBB) is a simulation-based neonatal resuscitation program for low resource settings. We studied the impact of initial HBB training followed by refresher training on the knowledge and skills of the birth attendants in facilities. METHODS: We conducted HBB trainings in 71 facilities in the NICHD Global Network research sites (Nagpur and Belgaum, India and Eldoret, Kenya), with a 6:1 ratio of facility trainees to Master Trainers (MT)...
November 22, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27824939/factors-associated-with-maternal-serum-levels-of-perfluoroalkyl-substances-and-organochlorines-a-descriptive-study-of-parous-women-in-norway-and-sweden
#12
Hilde B Lauritzen, Tricia L Larose, Torbjørn Øien, Jon Ø Odland, Margot van de Bor, Geir W Jacobsen, Torkjel M Sandanger
INTRODUCTION: Perfluoroalkyl substances (PFASs) and organochlorines (OCs) are ubiquitous and persistent in the environment and proposed endocrine disrupting chemicals (EDCs). They can be transferred across the placenta during pregnancy, and studies suggest that the prenatal period may be particularly sensitive for influences on fetal growth and development. Several studies have investigated socio-demographic and pregnancy related factors associated with maternal serum PFAS and OC levels, but few studies have been conducted in time periods with increasing emissions of PFASs and recent emissions of OCs...
2016: PloS One
https://www.readbyqxmd.com/read/27824768/relationship-between-excessive-gestational-weight-gain-and-neonatal-adiposity-in-women-with-mild-gestational-diabetes-mellitus
#13
Sean C Blackwell, Mark B Landon, Lisa Mele, Uma M Reddy, Brian M Casey, Ronald J Wapner, Michael W Varner, Dwight J Rouse, John M Thorp, Anthony Sciscione, Patrick Catalano, George Saade, Steve N Caritis, Yoram Sorokin, William A Grobman
OBJECTIVE: To evaluate the relationships among excessive gestational weight gain, neonatal adiposity, and adverse obstetric outcomes in women with mild gestational diabetes mellitus. METHODS: This is a secondary analysis of a multicenter randomized clinical trial of women with mild gestational diabetes mellitus. Based on self-reported prepregnancy body weight, gestational weight gain was categorized as excessive if it was greater than 2009 Institute of Medicine guidelines...
December 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27819172/deceleration-area-and-fetal-academia
#14
Sabina Marti Gamboa, Maria Lapresta Moros, Jara Pascual Mancho, Carlos Lapresta Moros, Sergio Castán
AIMS: To compare the predictive ability for neonatal acidemia of individual components of intrapartum cardiotocography (CTG) described by National Institute of Child Health and Human Development (NICHD) system and deceleration area. DESIGN: Case-control study. SETTING: Spanish tertiary obstetrical hospital. POPULATION: CTG patterns of 102 acidemic fetus (umbilical arterial cord gas pH≤7.10, base deficit (BD)>8) and 102 non-acidemic controls (umbilical arterial cord gas pH > 7...
November 6, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27786532/relations-between-three-dopaminergic-system-genes-school-attachment-and-adolescent-delinquency
#15
Adam Fine, Alissa Mahler, Cortney Simmons, Chuansheng Chen, Robert Moyzis, Elizabeth Cauffman
Both environmental factors and genetic variation, particularly in genes responsible for the dopaminergic system such as DRD4, DRD2, and DAT1 (SLC6A3), affect adolescent delinquency. The school context, despite its developmental importance, has been overlooked in gene-environment research. Using data from the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development (NICHD ECCYD), this study examined key interactions between school attachment and (a) each of the DRD4, DRD2, and DAT1 (SLC6A3) genotypes; and (b) a polygenic score...
November 2016: Developmental Psychology
https://www.readbyqxmd.com/read/27760543/risk-factors-for-possible-serious-bacterial-infection-in-a-rural-cohort-of-young-infants-in-central-india
#16
Marie E Wang, Archana B Patel, Nellie I Hansen, Lauren Arlington, Amber Prakash, Patricia L Hibberd
BACKGROUND: Possible serious bacterial infection (PBSI) is a major cause of neonatal mortality worldwide. We studied risk factors for PSBI in a large rural population in central India where facility deliveries have increased as a result of a government financial assistance program. METHODS: We studied 37,379 pregnant women and their singleton live born infants with birth weight ≥ 1.5 kg from 20 rural primary health centers around Nagpur, India, using data from the 2010-13 population-based Maternal and Newborn Health Registry supported by NICHD's Global Network for Women's and Children's Health Research...
October 19, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27753764/inherent-risk-factors-for-nosocomial-infection-in-the-long-stay-critically-ill-child-without-known-baseline-immunocompromise-a-post-hoc-analysis-of-the-crisis-trial
#17
Joseph A Carcillo, J Michael Dean, Richard Holubkov, John Berger, Kathleen L Meert, Kanwaljeet J S Anand, Jerry Zimmerman, Christopher J Newth, Rick Harrison, Jeri Burr, Douglas F Willson, Carol Nicholson, Michael J Bell, Robert A Berg, Thomas P Shanley, Sabrina M Heidemann, Heidi Dalton, Tammara L Jenkins, Allan Doctor, Angie Webster
BACKGROUND: Nosocomial infection remains an important health problem in long stay (>3 days) pediatric intensive care unit (PICU) patients. Admission risk factors related to the development of nosocomial infection in long stay immune competent patients in particular are not known. METHODS: Post-hoc analysis of the previously published Critical Illness Stress induced Immune Suppression (CRISIS) prevention trial database, to identify baseline risk factors for nosocomial infection...
November 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27741203/maternal-and-neonatal-outcomes-with-early-compared-with-delayed-pushing-among-nulliparous-women
#18
Lynn M Yee, Grecio Sandoval, Jennifer Bailit, Uma M Reddy, Ronald J Wapner, Michael W Varner, Steve N Caritis, Mona Prasad, Alan T N Tita, George Saade, Yoram Sorokin, Dwight J Rouse, Sean C Blackwell, Jorge E Tolosa
OBJECTIVE: To describe factors associated with delayed pushing and evaluate the relationship between delayed pushing and perinatal outcomes in nulliparous women with singleton term gestations. METHODS: This was a secondary analysis of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Assessment of Perinatal Excellence cohort of 115,502 women and their neonates born in 25 U.S. hospitals from 2008 to 2011. Nulliparous women with singleton, cephalic, nonanomalous term births who achieved 10-cm cervical dilation were included...
November 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27722031/categorizing-fetal-heart-rate-variability-with-and-without-visual-aids
#19
Amanda J Ashdown, Mark W Scerbo, Lee A Belfore, Stephen S Davis, Alfred Z Abuhamad
Objective This study examined the ability of clinicians to correctly categorize images of fetal heart rate (FHR) variability with and without the use of exemplars. Study Design A sample of 33 labor and delivery clinicians inspected static FHR images and categorized them into one of four categories defined by the National Institute of Child Health and Human Development (NICHD) based on the amount of variability within absent, minimal, moderate, or marked ranges. Participants took part in three conditions: two in which they used exemplars representing FHR variability near the center or near the boundaries of each range, and a third control condition with no exemplars...
October 2016: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/27690496/early-child-care-and-adolescent-functioning-at-the-end-of-high-school-results-from-the-nichd-study-of-early-child-care-and-youth-development
#20
Deborah Lowe Vandell, Margaret Burchinal, Kim M Pierce
Relations between early child care and adolescent functioning at the end of high school (EOHS; M age = 18.3 years) were examined in a prospective longitudinal study of 1,214 children. Controlling for extensive measures of family background, early child care was associated with academic standing and behavioral adjustment at the EOHS. More experience in center-type care was linked to higher class rank and admission to more selective colleges, and for females to less risk taking and greater impulse control. Higher quality child care predicted higher academic grades and admission to more selective colleges...
October 2016: Developmental Psychology
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