keyword
https://read.qxmd.com/read/36595343/comparable%C3%A2-kidney-transplant-outcomes-in-selected-patients-with-a-body-mass-index-%C3%A2-40-a-personalized-medicine-approach-to-recipient-selection
#21
JOURNAL ARTICLE
Marie L Jacobs, Karanpreet Dhaliwal, David I Harriman, Jeffrey Rogers, Robert J Stratta, Alan C Farney, Giuseppe Orlando, Amber Reeves-Daniel, Colleen Jay
INTRODUCTION: Many kidney transplant (KT) centers decline patients with a body mass index (BMI) ≥40 kg/m2 . This study's aim was to evaluate KT outcomes according to recipient BMI. METHODS: We performed a single-center, retrospective review of adult KTs comparing BMI ≥40 patients (n = 84, BMI = 42±2 kg/m2 ) to a matched BMI <40 cohort (n = 84, BMI = 28±5 kg/m2 ). Patients were matched for age, gender, race, diabetes, and donor type. RESULTS: BMI ≥40 patients were on dialysis longer (5...
January 3, 2023: Clinical Transplantation
https://read.qxmd.com/read/36587842/dysregulated-systemic-metabolism-in-a-down-syndrome-mouse-model
#22
JOURNAL ARTICLE
Dylan C Sarver, Cheng Xu, Leandro M Velez, Susan Aja, Andrew E Jaffe, Marcus M Seldin, Roger H Reeves, G William Wong
OBJECTIVE: Trisomy 21 is one of the most complex genetic perturbations compatible with postnatal survival. Dosage imbalance arising from the triplication of genes on human chromosome 21 (Hsa21) affects multiple organ systems. Much of Down syndrome (DS) research, however, has focused on addressing how aneuploidy dysregulates CNS function leading to cognitive deficit. Although obesity, diabetes, and associated sequelae such as fatty liver and dyslipidemia are well documented in the DS population, only limited studies have been conducted to determine how gene dosage imbalance affects whole-body metabolism...
December 29, 2022: Molecular Metabolism
https://read.qxmd.com/read/36535713/outcome-monitoring-after-cardiac-surgery-omacs-a-single-centre-prospective-cohort-study-of-cardiac-surgery-patients
#23
JOURNAL ARTICLE
Terrie Walker-Smith, Katherine Joyce, Rachel Maishman, Helena Smartt, Emma Hopkins, Rachel Brierley, Barnaby C Reeves, Chris A Rogers, Gianni D Angelini, Lucy Culliford
INTRODUCTION: More than 30 000 cardiac surgery procedures are performed in the UK each year, however, postoperative complications and long-term failure of interventions are common, leading to repeated surgeries. This represents a significant burden on the patient and health service.Routinely, patients are discharged to their general practitioner 6 weeks postoperatively and research studies typically only report short-term outcomes up to 1 year after surgery, together this makes long-term outcomes of cardiac surgery difficult to monitor...
December 19, 2022: BMJ Open
https://read.qxmd.com/read/36524320/long-term-outcomes-of-kidney-transplantation-from-deceased-donors-with-terminal-acute-kidney-injury-single-center-experience-and-literature-review
#24
REVIEW
Matthew Garner, Colleen L Jay, Berjesh Sharda, Christopher Webb, Alan C Farney, Giuseppe Orlando, Jeffrey Rogers, Amber Reeves-Daniel, Alejandra Mena-Gutierrez, Natalia Sakhovskaya, Bobby Stratta, Robert J Stratta
INTRODUCTION: Long-term outcomes of kidney transplantation from deceased donors (DDKTs) with terminal acute kidney injury (AKI) are not well defined. METHODS: Single center retrospective review of DDKTs from 1/31/07-12/31/19. AKI kidneys were defined by a doubling of the donor's admission serum creatinine (SCr) level AND a terminal SCr ≥2.0 mg/dl. RESULTS: 188 AKI DDKTs were performed, including 154 from brain-dead standard criteria donors (SCD)...
December 15, 2022: Clinical Transplantation
https://read.qxmd.com/read/36484997/an-activity-based-oxaziridine-platform-for-identifying-and-developing-covalent-ligands-for-functional-allosteric-methionine-sites-redox-dependent-inhibition-of-cyclin-dependent-kinase-4
#25
JOURNAL ARTICLE
Angel Gonzalez-Valero, Audrey G Reeves, Annika C S Page, Patrick J Moon, Edward Miller, Katia Coulonval, Steven W M Crossley, Xiao Xie, Dan He, Patricia Z Musacchio, Alec H Christian, Jeffrey M McKenna, Richard A Lewis, Eric Fang, Dustin Dovala, Yipin Lu, Lynn M McGregor, Markus Schirle, John A Tallarico, Pierre P Roger, F Dean Toste, Christopher J Chang
Activity-based protein profiling (ABPP) is a versatile strategy for identifying and characterizing functional protein sites and compounds for therapeutic development. However, the vast majority of ABPP methods for covalent drug discovery target highly nucleophilic amino acids such as cysteine or lysine. Here, we report a methionine-directed ABPP platform using Redox-Activated Chemical Tagging (ReACT), which leverages a biomimetic oxidative ligation strategy for selective methionine modification. Application of ReACT to oncoprotein cyclin-dependent kinase 4 (CDK4) as a representative high-value drug target identified three new ligandable methionine sites...
December 9, 2022: Journal of the American Chemical Society
https://read.qxmd.com/read/36465463/a-cohort-study-of-circulating-progenitor-cells-after-st-segment-elevation-and-non-st-segment-elevation-myocardial-infarction-in-non-diabetic-and-diabetic-patients
#26
JOURNAL ARTICLE
Andreas Baumbach, Yu-Xin Cui, Rebecca N Evans, Lucy Culliford, Tom Johnson, Chris A Rogers, Barnaby C Reeves, Chiara Bucciarelli-Ducci, Jessica Harris, Mark Hamilton, Paolo Madeddu
BACKGROUND: Myocardial infarction induces elevation of progenitor cells in the circulation, a reparative response inhibited by type-2 diabetes. OBJECTIVES: Determine if myocardial infarct severity and diabetes interactively influence the migratory activity of CD34+/CXCR4+ progenitor cells and if the migratory test predicts cardiac outcomes. MATERIALS AND METHODS: A longitudinal study was conducted on patients with or without diabetes with a STEMI or NSTEMI...
2022: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/36294292/patient-acceptability-of-home-monitoring-for-neovascular-age-related-macular-degeneration-reactivation-a-qualitative-study
#27
JOURNAL ARTICLE
Seán R O'Connor, Charlene Treanor, Elizabeth Ward, Robin A Wickens, Abby O'Connell, Lucy A Culliford, Chris A Rogers, Eleanor A Gidman, Tunde Peto, Paul C Knox, Benjamin J L Burton, Andrew J Lotery, Sobha Sivaprasad, Barnaby C Reeves, Ruth E Hogg, Michael Donnelly, Monarch Study Group
Neovascular age-related macular degeneration (nAMD) is a chronic, progressive condition and the commonest cause of visual disability in older adults. This study formed part of a diagnostic test accuracy study to quantify the ability of three index home monitoring (HM) tests (one paper-based and two digital tests) to identify reactivation in nAMD. The aim of this qualitative research was to investigate patients' or participants' views about acceptability and explore adherence to weekly HM. Semi-structured interviews were held with 78/297 participants (26%), with close family members (n = 11) and with healthcare professionals involved in training participants in HM procedures (n = 9) (n = 98 in total)...
October 21, 2022: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/36234425/wavelength-selective-solar-cells-using-triple-cation-perovskite
#28
JOURNAL ARTICLE
Ahmed Hayali, Roger J Reeves, Maan M Alkaisi
Perovskite materials offer high-efficiency low-cost solar cells and applications versatility. We report on cesium-based hybrid perovskite solar cells with wavelength-selective properties ranging from 500 nm (UV-VIS) to 800 nm (IR). The band gap tuning was achieved through composition changes of mainly lead(II) iodide PbI2 and lead(II) bromide PbBr2. The optical spectra of the developed materials were studied, including the photoluminescence (PL), optical transparency, X-ray diffraction and external quantum efficiency for samples prepared under different compositions...
September 22, 2022: Nanomaterials
https://read.qxmd.com/read/36115625/the-uniformed-services-constipation-action-plan-an-effective-tool-for-the-management-of-children-with-functional-constipation
#29
JOURNAL ARTICLE
Patrick T Reeves, Benjamin O Jack, Philip L Rogers, Nathan T Kolasinski, Carolyn Sullivan Burklow, Steve B Min, Cade M Nylund
OBJECTIVE: To implement and to evaluate the effectiveness of the Uniformed Services Constipation Action Plan (USCAP) in our gastroenterology clinic for children with functional constipation. STUDY DESIGN: This implementation science study included toilet-trained subjects aged 4 years and older who met the Rome IV criteria for functional constipation. Children were block randomized to receive either the USCAP or control. All clinic functional constipation plans recommended subjects continue pharmacotherapy for 4 months...
September 15, 2022: Journal of Pediatrics
https://read.qxmd.com/read/35954844/the-covid-19-pandemic-and-ophthalmic-care-a-qualitative-study-of-patients-with-neovascular-age-related-macular-degeneration-namd
#30
JOURNAL ARTICLE
Seán R O'Connor, Charlene Treanor, Elizabeth Ward, Robin A Wickens, Abby O'Connell, Lucy A Culliford, Chris A Rogers, Eleanor A Gidman, Tunde Peto, Paul C Knox, Benjamin J L Burton, Andrew J Lotery, Sobha Sivaprasad, Barnaby C Reeves, Ruth E Hogg, Michael Donnelly, Monarch Study Group
Concerns have been expressed about the relationship between reduced levels of health care utilisation and the COVID-19 pandemic. This study aimed to elicit and explore the views of patients with neovascular age-related macular degeneration (nAMD) regarding the COVID-19 pandemic and their ophthalmic care. Semi-structured telephone interviews were conducted with thirty-five patients with nAMD taking part in a larger diagnostic accuracy study of home-monitoring tests. Participants were recruited using maximum variation sampling to capture a range of key characteristics including age, gender and time since initial treatment...
August 2, 2022: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/35900186/listening-to-the-patient-voice-adds-value-to-cancer-clinical-trials
#31
JOURNAL ARTICLE
Michael D Brundage, Norah L Crossnohere, Jennifer O'Donnell, Samantha Cruz Rivera, Roger Wilson, Albert W Wu, Moher David, Derek Kyte, Bryce B Reeve, Alexandra Gilbert, Ronald C Chen, Melanie J Calvert, Claire Snyder
Randomized clinical trials are critical for evaluating the safety and efficacy of interventions in oncology and informing regulatory decisions, practice guidelines, and health policy. Patient-reported outcomes (PROs) are increasingly used in randomized trials to reflect the impact of receiving cancer therapies from the patient perspective and can inform evaluations of interventions by providing evidence that cannot be obtained or deduced from clinicians' reports or from other biomedical measures. This commentary focuses on how PROs add value to clinical trials by representing the patient voice...
July 28, 2022: Journal of the National Cancer Institute
https://read.qxmd.com/read/35850975/recommendations-for-the-execution-and-reporting-of-skin-ultrasound-in-systemic-sclerosis-an-international-collaboration-under-the-wsf-skin-ultrasound-group
#32
JOURNAL ARTICLE
Tânia Santiago, Eduardo José Ferreira Santos, Barbara Ruaro, Gemma Lepri, Lorraine Green, Marie Wildt, Shinji Watanabe, Alain Lescoat, Roger Hesselstrand, Francesco Del Galdo, John D Pauling, Lucy Jean Reeve, Maria Antonieta D'Agostino, Marco Matucci-Cerinic, Annamaria Iagnocco, Jose Antonio Pereira da Silva
OBJECTIVE: Ultrasound is a promising tool to foster much-needed improvement of skin assessment in systemic sclerosis (SSc). Our aim was to develop evidence and expert opinion-based recommendations to promote the standardisation and harmonisation of technical execution and reporting of skin ultrasound studies in SSc. METHODS: A multidisciplinary task force of 16 members from five European countries and Japan was convened under the auspices of World Scleroderma Foundation...
July 2022: RMD Open
https://read.qxmd.com/read/35687574/neonatal-hemorrhoids-getting-to-the-bottom-of-an-uncommon-finding
#33
JOURNAL ARTICLE
Brian Graziose, Philip L Rogers, Jeffrey R Greenwald, Patrick T Reeves
No abstract text is available yet for this article.
June 10, 2022: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/35658804/development-and-assessment-of-a-low-literacy-pictographic-asthma-action-plan-with-clinical-automation-to-enhance-guideline-concordant-care-for-children-with-asthma
#34
JOURNAL ARTICLE
Patrick T Reeves, Timothy M Kenny, Laura T Mulreany, Michael Y McCown, Jane E Jacknewitz-Woolard, Philip L Rogers, Sofia Echelmeyer, Sebastian K Welsh
OBJECTIVE: Asthma is characterized by reversible pulmonary symptoms, frequent hospitalizations, poor quality of life, and varied treatment. Parents with low health literacy (HL) is linked to poor asthma outcomes in children. Recent practice updates recommended inhaled corticosteroids for the management of persistent asthma, but guideline-concordant care is suboptimal. Our aim was to develop and assess an Asthma Action Plan (AAP) that could serve as an individualized plan for low HL families and facilitate guideline-concordant care for clinicians...
June 16, 2022: Journal of Asthma
https://read.qxmd.com/read/35559460/craniofacial-morphology-of-a-new-mouse-model-of-down-syndrome
#35
JOURNAL ARTICLE
Nandini Singh, Joan T Richtsmeier, Roger Reeves
Down syndrome (DS) is a complex condition caused by triplication of human chromosome 21 (Hsa21). Several mouse models have been developed to study the genotypic and phenotypic outcomes of DS. The most extensively studied and used in DS research is Ts65Dn. More recently, the TcMAC21 - a transchromosomic mouse strain with comparable gene dosage to Hsa21 - was developed, and represents a more complete genetic mouse model of DS than Ts65Dn. While Ts65Dn has been the focus of several studies, relatively little is known about the craniofacial phenotype of TcMAC21 mice relative to the other DS mouse models...
May 2022: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/35547853/adaptive-mhc-e-restricted-tissue-resident-nk-cells-are-associated-with-persistent-low-antigen-load-in-alveolar-macrophages-after-sars-cov-2-infection
#36
Nicolas Huot, Cyril Planchais, Vanessa Contreras, Beatrice Jacquelin, Caroline Petitdemange, Marie Lazzerini, Pierre Rosenbaum, Félix Rey, R Keith Reeves, Roger Le Grand, Hugo Mouquet, Michaela Müller-Trutwin
Natural killer (NK) cells are innate lymphocytes with potent activity against a wide range of viruses. In SARS-CoV-2 infection, NK cell activity might be of particular importance within lung tissues. Here, we investigated whether NK cells with activity against Spike + cells are induced during SARS-CoV-2 infection and have a role in modulating viral persistence beyond primary clearance from nasopharyngeal and tracheal tissues. We performed an integrated analysis of NK cells and macrophages in blood and bronchoalveolar lavage fluids (BALF) of COVID-19 convalescent non-human primates in comparison to uninfected control animals...
April 25, 2022: Research Square
https://read.qxmd.com/read/35477863/cxcr2-inhibition-enables-nash-hcc-immunotherapy
#37
JOURNAL ARTICLE
Jack Leslie, John B G Mackey, Thomas Jamieson, Erik Ramon-Gil, Thomas M Drake, Frédéric Fercoq, William Clark, Kathryn Gilroy, Ann Hedley, Colin Nixon, Saimir Luli, Maja Laszczewska, Roser Pinyol, Roger Esteban-Fabró, Catherine E Willoughby, Philipp K Haber, Carmen Andreu-Oller, Mohammad Rahbari, Chaofan Fan, Dominik Pfister, Shreya Raman, Niall Wilson, Miryam Müller, Amy Collins, Daniel Geh, Andrew Fuller, David McDonald, Gillian Hulme, Andrew Filby, Xabier Cortes-Lavaud, Noha-Ehssan Mohamed, Catriona A Ford, Ximena L Raffo Iraolagoitia, Amanda J McFarlane, Misti V McCain, Rachel A Ridgway, Edward W Roberts, Simon T Barry, Gerard J Graham, Mathias Heikenwälder, Helen L Reeves, Josep M Llovet, Leo M Carlin, Thomas G Bird, Owen J Sansom, Derek A Mann
OBJECTIVE: Hepatocellular carcinoma (HCC) is increasingly associated with non-alcoholic steatohepatitis (NASH). HCC immunotherapy offers great promise; however, recent data suggests NASH-HCC may be less sensitive to conventional immune checkpoint inhibition (ICI). We hypothesised that targeting neutrophils using a CXCR2 small molecule inhibitor may sensitise NASH-HCC to ICI therapy. DESIGN: Neutrophil infiltration was characterised in human HCC and mouse models of HCC...
April 27, 2022: Gut
https://read.qxmd.com/read/35426781/supraglottic-airway-device-versus-tracheal-intubation-in-the-initial-airway-management-of-out-of-hospital-cardiac-arrest-the-airways-2-cluster-rct
#38
RANDOMIZED CONTROLLED TRIAL
Jonathan R Benger, Kim Kirby, Sarah Black, Stephen J Brett, Madeleine Clout, Michelle J Lazaroo, Jerry P Nolan, Barnaby C Reeves, Maria Robinson, Lauren J Scott, Helena Smartt, Adrian South, Elizabeth A Stokes, Jodi Taylor, Matthew Thomas, Sarah Voss, Sarah Wordsworth, Chris A Rogers
BACKGROUND: When a cardiac arrest occurs, cardiopulmonary resuscitation should be started immediately. However, there is limited evidence about the best approach to airway management during cardiac arrest. OBJECTIVE: The objective was to determine whether or not the i-gel® (Intersurgical Ltd, Wokingham, UK) supraglottic airway is superior to tracheal intubation as the initial advanced airway management strategy in adults with non-traumatic out-of-hospital cardiac arrest...
April 2022: Health Technology Assessment: HTA
https://read.qxmd.com/read/35343853/the-use-of-patient-reported-outcome-measures-to-classify-type-1-and-2-systemic-lupus-erythematosus-activity
#39
JOURNAL ARTICLE
Amanda M Eudy, Bryce B Reeve, Theresa Coles, Li Lin, Jennifer L Rogers, David S Pisetsky, Lisa G Criscione-Schreiber, Jayanth Doss, Rebecca Sadun, Kai Sun, Megan Eb Clowse
OBJECTIVE: We developed a model that categorizes systemic lupus erythematosus (SLE) activity into two dimensions: Type 1 SLE consists of inflammatory activity, including arthritis, nephritis, and rashes; Type 2 SLE includes fatigue, myalgia, mood disturbance, and cognitive dysfunction. Patient-reported outcome (PRO) measures have received attention as a way to capture symptomatology of SLE. The objective of this study was to explore the use of existing PRO measures to classify Type 1 and 2 SLE activity...
May 2022: Lupus
https://read.qxmd.com/read/35314388/long-term-retinal-morphology-and-functional-associations-in-treated-neovascular-age-related-macular-degeneration-findings-from-the-inhibition-of-vegf-in-age-related-choroidal-neovascularisation-trial
#40
MULTICENTER STUDY
Tunde Peto, Rebecca N Evans, Barnaby C Reeves, Simon Harding, Savita Madhusudhan, Andrew Lotery, Susan Downes, Konstantinos Balaskas, Clare C Bailey, Alexander Foss, Faruque Ghanchi, Yit Yang, Dawn Phillips, Chris A Rogers, Alyson Muldrew, Barbra Hamill, Usha Chakravarthy
PURPOSE: To describe the frequency of long-term morphologic features and their relationships with visual function in participants who exited the Inhibition of VEGF in Age-Related Choroidal Neovascularisation (IVAN; ISRCTN92166560) trial. DESIGN: Multicenter cohort study up to 7 years after enrollment. PARTICIPANTS: Patients enrolled in the IVAN trial, excluding participants who died or withdrew during the trial. METHODS: Multimodal fundus images, best-corrected visual acuity (BCVA), and low-luminance visual acuity (LLVA) were obtained for a subset of 199 participants who attended a research visit...
August 2022: Ophthalmology Retina
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