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Roger Reeves

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https://www.readbyqxmd.com/read/27898680/a-core-outcome-set-for-the-benefits-and-adverse-events-of-bariatric-and-metabolic-surgery-the-bariact-project
#1
Karen D Coulman, James Hopkins, Sara T Brookes, Katy Chalmers, Barry Main, Amanda Owen-Smith, Robert C Andrews, James Byrne, Jenny L Donovan, Graziella Mazza, Barnaby C Reeves, Chris A Rogers, Janice L Thompson, Richard Welbourn, Sarah Wordsworth, Jane M Blazeby
BACKGROUND: Bariatric and metabolic surgery is used as a treatment for patients with severe and complex obesity. However, there is a need to improve outcome selection and reporting in bariatric surgery trials. A Core Outcome Set (COS), an agreed minimum set of outcomes reported in all studies of a specific condition, may achieve this. Here, we present the development of a COS for BARIAtric and metabolic surgery Clinical Trials-the BARIACT Study. METHODS AND FINDINGS: Outcomes identified from systematic reviews and patient interviews informed a questionnaire survey...
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27867340/changing-paradigms-in-down-syndrome-the-first-international-conference-of-the-trisomy-21-research-society
#2
Jean-Maurice Delabar, Bernadette Allinquant, Diana Bianchi, Tom Blumenthal, Alain Dekker, Jamie Edgin, John O'Bryan, Mara Dierssen, Marie-Claude Potier, Frances Wiseman, Faycal Guedj, Nicole Créau, Roger Reeves, Katheleen Gardiner, Jorge Busciglio
Down syndrome (DS) is the most common genetic cause of intellectual disability (ID) in humans with an incidence of ∼1:1,000 live births worldwide. It is caused by the presence of an extra copy of all or a segment of the long arm of human chromosome 21 (trisomy 21). People with DS present with a constellation of phenotypic alterations involving most organs and organ systems. ID is present in all people with DS, albeit with variable severity. DS is also the most frequent genetic cause of Alzheimer's disease (AD), and ∼50% of those with DS will develop AD-related dementia...
October 2016: Molecular Syndromology
https://www.readbyqxmd.com/read/27859268/heterogeneity-of-colorectal-cancer-risk-by-tumour-characteristics-large-prospective-study-of-uk-women
#3
Andrea Burón Pust, Rupert Alison, Roger Blanks, Kirstin Pirie, Kezia Gaitskell, Isobel Barnes, Toral Gathani, Gillian Reeves, Valerie Beral, Jane Green
Associations between behavioural and other personal factors and colorectal cancer risk have been reported to vary by tumour characteristics, but evidence is inconsistent. In a large UK-based prospective study we examined associations of 14 postulated risk factors with colorectal cancer risk overall, and across 3 anatomical sites and 4 morphological subtypes. Among 1.3 million women, 18,518 incident colorectal cancers were identified during 13.8 (SD 3.4) years follow-up via record linkage to national cancer registry data...
November 18, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27809956/the-effectiveness-cost-effectiveness-and-acceptability-of-community-versus-hospital-eye-service-follow-up-for-patients-with-neovascular-age-related-macular-degeneration-with-quiescent-disease-echoes-a-virtual-randomised-balanced-incomplete-block-trial
#4
Barnaby C Reeves, Lauren J Scott, Jodi Taylor, Ruth Hogg, Chris A Rogers, Sarah Wordsworth, Daisy Townsend, Alyson Muldrew, Tunde Peto, Mara Violato, Helen Dakin, Heike Cappel-Porter, Nicola Mills, Dermot O'Reilly, Simon P Harding, Usha Chakravarthy
BACKGROUND: Patients with neovascular age-related macular degeneration (nAMD) usually attend regular reviews, even when the disease is quiescent. Reviews are burdensome to health services, patients and carers. OBJECTIVES: To compare the proportion of correct lesion classifications made by community-based optometrists and ophthalmologists from vignettes of patients; to estimate the cost-effectiveness of community follow-up by optometrists compared with follow-up by ophthalmologists in the Hospital Eye Service (HES); to ascertain views of patients, their representatives, optometrists, ophthalmologists and clinical commissioners on the proposed shared care model...
October 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27797985/cost-effectiveness-of-community-versus-hospital-eye-service-follow-up-for-patients-with-quiescent-treated-age-related-macular-degeneration-alongside-the-echoes-randomised-trial
#5
M Violato, H Dakin, U Chakravarthy, B C Reeves, T Peto, R E Hogg, S P Harding, L J Scott, J Taylor, H Cappel-Porter, N Mills, D O'Reilly, C A Rogers, S Wordsworth
OBJECTIVES: To assess the cost-effectiveness of optometrist-led follow-up monitoring reviews for patients with quiescent neovascular age-related macular degeneration (nAMD) in community settings (including high street opticians) compared with ophthalmologist-led reviews in hospitals. DESIGN: A model-based cost-effectiveness analysis with a 4-week time horizon, based on a 'virtual' non-inferiority randomised trial designed to emulate a parallel group design. SETTING: A virtual internet-based clinical assessment, conducted at community optometry practices, and hospital ophthalmology clinics...
October 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27768292/tuning-the-band-bending-and-controlling-the-surface-reactivity-at-polar-and-non-polar-surfaces-of-zno-through-phosphonic-acid-binding
#6
Alexandra R McNeill, Adam R Hyndman, Roger J Reeves, Alison J Downard, Martin Ward Allen
ZnO is a prime candidate for future use in transparent electronics however development of practical materials requires attention to factors including control of its unusual surface band bending and surface reactivity. In this work, we have modified the O polar (000(1)over bar), Zn-polar (0001), and m-plane (10(1)over bar0) surfaces of ZnO with phosphonic acid (PA) derivatives and measured the effect on the surface band bending and surface sensitivity to atmospheric oxygen. Core level and valence band synchrotron X-ray photoemission spectroscopy were used to measure the surface band bending introduced by PA modifiers with substituents of opposite polarity dipole moment: octadecylphosphonic acid (ODPA) and 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctylphosphonic acid (F13OPA)...
October 21, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27746614/urinary-metabotyping-of-hepatocellular-carcinoma-in-a-uk-cohort-using-proton-nuclear-magnetic-resonance-spectroscopy
#7
Mohamed I F Shariff, Jin U Kim, Nimzing G Ladep, Mary M E Crossey, Larry K Koomson, Abigail Zabron, Helen Reeves, Matthew Cramp, Stephen Ryder, Shaun Greer, I Jane Cox, Roger Williams, Elaine Holmes, Kathryn Nash, Simon D Taylor-Robinson
BACKGROUND: Discriminatory metabolic profiles have been described in urinary (1)H nuclear magnetic resonance (NMR) spectroscopy studies of African patients with hepatocellular carcinoma (HCC). This study aimed to assess similarities in a UK cohort, where there is a greater etiological diversity. METHODS: Urine from cirrhosis and HCC patients was analyzed using a 600 MHz (1)H NMR system. Multivariate analysis and median group MR spectra comparison identified metabolite alterations between groups...
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27697605/design-and-implementation-of-the-airways-2-trial-a-multi-centre-cluster-randomised-controlled-trial-of-the-clinical-and-cost-effectiveness-of-the-i-gel-supraglottic-airway-device-versus-tracheal-intubation-in-the-initial-airway-management-of-out-of-hospital
#8
Jodi Taylor, Sarah Black, Stephen J Brett, Kim Kirby, Jerry P Nolan, Barnaby C Reeves, Maria Robinson, Chris A Rogers, Lauren J Scott, Adrian South, Elizabeth A Stokes, Matthew Thomas, Sarah Voss, Sarah Wordsworth, Jonathan R Benger
Health outcomes after out of hospital cardiac arrest (OHCA) are extremely poor, with only 7-9% of patients in the United Kingdom (UK) surviving to hospital discharge. Currently emergency medical services (EMS) use either tracheal intubation or newer supraglottic airway devices (SGAs) to provide advanced airway management during OHCA. Equipoise between the two techniques has led to calls for a well-designed randomised controlled trial. The primary objective of the AIRWAYS-2 trial is to assess whether the clinical effectiveness of the i-gel, a second-generation SGA, is superior to tracheal intubation in the initial airway management of OHCA patients in the UK...
December 2016: Resuscitation
https://www.readbyqxmd.com/read/27648982/the-healthcare-costs-of-heart-failure-during-the-last-five-years-of-life-a-retrospective-cohort-study
#9
William Hollingworth, Mousumi Biswas, Rachel L Maishman, Mark J Dayer, Theresa McDonagh, Sarah Purdy, Barnaby C Reeves, Chris A Rogers, Rachael Williams, Maria Pufulete
BACKGROUND: Evidence on the economic impact of heart failure (HF) is vital in order to predict the cost-effectiveness of novel interventions. We estimate the health system costs of HF during the last five years of life. METHODS: We used linked primary care and mortality data accessed through the Clinical Practice Research Datalink (CPRD) to identify 1555 adults in England who died with HF in 2012/13. We used CPRD and linked Hospital Episode Statistics to estimate the cost of medications, primary and hospital healthcare...
December 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27527344/a-multicentre-randomised-controlled-trial-of-transfusion-indication-threshold-reduction-on-transfusion-rates-morbidity-and-health-care-resource-use-following-cardiac-surgery-titre2
#10
Barnaby C Reeves, Katie Pike, Chris A Rogers, Rachel Cm Brierley, Elizabeth A Stokes, Sarah Wordsworth, Rachel L Nash, Alice Miles, Andrew D Mumford, Alan Cohen, Gianni D Angelini, Gavin J Murphy
BACKGROUND: Uncertainty about optimal red blood cell transfusion thresholds in cardiac surgery is reflected in widely varying transfusion rates between surgeons and cardiac centres. OBJECTIVE: To test the hypothesis that a restrictive compared with a liberal threshold for red blood cell transfusion after cardiac surgery reduces post-operative morbidity and health-care costs. DESIGN: Multicentre, parallel randomised controlled trial and within-trial cost-utility analysis from a UK NHS and Personal Social Services perspective...
August 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27523088/training-for-impact-the-socio-economic-impact-of-a-fit-for-purpose-health-workforce-on-communities
#11
Björg Pálsdóttir, Jean Barry, Andreia Bruno, Hugh Barr, Amy Clithero, Nadia Cobb, Jan De Maeseneer, Elsie Kiguli-Malwadde, André-Jacques Neusy, Scott Reeves, Roger Strasser, Paul Worley
Across the globe, a "fit for purpose" health professional workforce is needed to meet health needs and challenges while capitalizing on existing resources and strengths of communities. However, the socio-economic impact of educating and deploying a fit for purpose health workforce can be challenging to evaluate. In this paper, we provide a brief overview of six promising strategies and interventions that provide context-relevant health professional education within the health system. The strategies focused on in the paper are:1...
2016: Human Resources for Health
https://www.readbyqxmd.com/read/27401357/effectiveness-of-community-versus-hospital-eye-service-follow-up-for-patients-with-neovascular-age-related-macular-degeneration-with-quiescent-disease-echoes-a-virtual-non-inferiority-trial
#12
Barnaby C Reeves, Lauren J Scott, Jodi Taylor, Simon P Harding, Tunde Peto, Alyson Muldrew, Ruth E Hogg, Sarah Wordsworth, Nicola Mills, Dermot O'Reilly, Chris A Rogers, Usha Chakravarthy
OBJECTIVES: To compare the ability of ophthalmologists versus optometrists to correctly classify retinal lesions due to neovascular age-related macular degeneration (nAMD). DESIGN: Randomised balanced incomplete block trial. Optometrists in the community and ophthalmologists in the Hospital Eye Service classified lesions from vignettes comprising clinical information, colour fundus photographs and optical coherence tomographic images. Participants' classifications were validated against experts' classifications (reference standard)...
2016: BMJ Open
https://www.readbyqxmd.com/read/27378871/editorial-intellectual-disabilities-in-down-syndrome-from-birth-and-throughout-life-assessment-and-treatment
#13
Marie-Claude Potier, Roger H Reeves
No abstract text is available yet for this article.
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27340223/cilia-gene-mutations-cause-atrioventricular-septal-defects-by-multiple-mechanisms
#14
Ozanna Burnicka-Turek, Jeffrey D Steimle, Wenhui Huang, Lindsay Felker, Anna Kamp, Junghun Kweon, Michael Peterson, Roger H Reeves, Cheryl L Maslen, Peter J Gruber, Xinan H Yang, Jay Shendure, Ivan P Moskowitz
Atrioventricular septal defects (AVSDs) are a common severe form of congenital heart disease (CHD). In this study we identified deleterious non-synonymous mutations in two cilia genes, Dnah11 and Mks1, in independent N-ethyl-N-nitrosourea-induced mouse mutant lines with heritable recessive AVSDs by whole-exome sequencing. Cilia are required for left/right body axis determination and second heart field (SHF) Hedgehog (Hh) signaling, and we find that cilia mutations affect these requirements differentially. Dnah11(avc)(4) did not disrupt SHF Hh signaling and caused AVSDs only concurrently with heterotaxy, a left/right axis abnormality...
June 23, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27138600/a-comparison-of-health-professionals-and-patients-views-of-the-importance-of-outcomes-of-bariatric-surgery
#15
Karen D Coulman, Noah Howes, James Hopkins, Katie Whale, Katy Chalmers, Sara Brookes, Alex Nicholson, Jelena Savovic, Yasmin Ferguson, Amanda Owen-Smith, Jane Blazeby, Jane Blazeby, Richard Welbourn, James Byrne, Jenny Donovan, Barnaby C Reeves, Sarah Wordsworth, Robert Andrews, Janice L Thompson, Graziella Mazza, Chris A Rogers
BACKGROUND: A comprehensive evaluation of bariatric surgery is required to inform decision-making. This will include measures of benefit and risk. It is possible that stakeholders involved with surgery value these outcomes differently, although this has not previously been explored. This study aimed to investigate and compare how professionals and patients prioritise outcomes of bariatric surgery. METHODS: Systematic reviews and qualitative interviews created an exhaustive list of outcomes...
May 2, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27084661/randomized-clinical-trial-comparing-proton-beam-radiation-therapy-with-transarterial-chemoembolization-for-hepatocellular-carcinoma-results-of-an-interim-analysis
#16
RANDOMIZED CONTROLLED TRIAL
David A Bush, Jason C Smith, Jerry D Slater, Michael L Volk, Mark E Reeves, Jason Cheng, Roger Grove, Michael E de Vera
PURPOSE: To describe results of a planned interim analysis of a prospective, randomized clinical trial developed to compare treatment outcomes among patients with newly diagnosed hepatocellular carcinoma (HCC). METHODS AND MATERIALS: Eligible subjects had either clinical or pathologic diagnosis of HCC and met either Milan or San Francisco transplant criteria. Patients were randomly assigned to transarterial chemoembolization (TACE) or to proton beam radiation therapy...
May 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27073205/changes-in-intraocular-pressure-in-study-and-fellow-eyes-in-the-ivan-trial
#17
Alexander J E Foss, Lauren J Scott, Chris A Rogers, Barney C Reeves, Faruque Ghanchi, Jonathan Gibson, Usha Chakravarthy
PURPOSE: To describe changes in intraocular pressure (IOP) in the 'alternative treatments to Inhibit VEGF in Age-related choroidal Neovascularisation (IVAN)' trial (registered as ISRCTN92166560). DESIGN: Randomised controlled clinical trial with factorial design. PARTICIPANTS: Patients (n=610) with treatment naïve neovascular age-related macular degeneration were enrolled and randomly assigned to receive either ranibizumab or bevacizumab and to two regimens, namely monthly (continuous) or as needed (discontinuous) treatment...
April 12, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27029737/penetrance-of-congenital-heart-disease-in-a-mouse-model-of-down-syndrome-depends-on-a-trisomic-potentiator-of-a-disomic-modifier
#18
Huiqing Li, Sarah Edie, Donna Klinedinst, Jun Seop Jeong, Seth Blackshaw, Cheryl L Maslen, Roger H Reeves
Down syndrome (DS) is a significant risk factor for congenital heart disease (CHD), increasing the incidence 50 times over the general population. However, half of people with DS have a normal heart and thus trisomy 21 is not sufficient to cause CHD by itself. Ts65Dn mice are trisomic for orthologs of >100 Hsa21 genes, and their heart defect frequency is significantly higher than their euploid littermates. Introduction of a null allele of Creld1 into Ts65Dn increases the penetrance of heart defects significantly...
June 2016: Genetics
https://www.readbyqxmd.com/read/27011923/single-vs-dual-en-bloc-kidney-transplants-from-donors-%C3%A2-5-years-of-age-a-single-center-experience
#19
Yousef Al-Shraideh, Umar Farooq, Hany El-Hennawy, Alan C Farney, Amudha Palanisamy, Jeffrey Rogers, Giuseppe Orlando, Muhammad Khan, Amber Reeves-Daniel, William Doares, Scott Kaczmorski, Michael D Gautreaux, Samy S Iskandar, Gloria Hairston, Elizabeth Brim, Margaret Mangus, Robert J Stratta
AIM: To compare outcomes between single and dual en bloc (EB) kidney transplants (KT) from small pediatric donors. METHODS: Monocentric nonprospective review of KTs from pediatric donors ≤ 5 years of age. Dual EB KT was defined as keeping both donor kidneys attached to the inferior vena cava and aorta, which were then used as venous and arterial conduits for the subsequent transplant into a single recipient. Donor age was less useful than either donor weight or kidney size in decision-making for kidney utilization as kidneys from donors < 8 kg or kidneys < 6 cm in length were not transplanted...
March 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/26782941/dual-kidney-transplants-from-adult-marginal-donors-successfully-expand-the-limited-deceased-donor-organ-pool
#20
Robert J Stratta, Alan C Farney, Giuseppe Orlando, Umar Farooq, Yousef Al-Shraideh, Amudha Palanisamy, Amber Reeves-Daniel, William Doares, Scott Kaczmorski, Michael D Gautreaux, Samy S Iskandar, Gloria Hairston, Elizabeth Brim, Margaret Mangus, Hany El-Hennawy, Muhammad Khan, Jeffrey Rogers
BACKGROUND: The need to expand the organ donor pool remains a formidable challenge in kidney transplantation (KT). The use of expanded criteria donors (ECDs) represents one approach, but kidney discard rates are high because of concerns regarding overall quality. Dual KT (DKT) may reduce organ discard and optimize the use of kidneys from marginal donors. STUDY DESIGN: We conducted a single-center retrospective review of outcomes in adult recipients of DKTs from adult marginal deceased donors (DD) defined by limited renal functional capacity...
April 2016: Clinical Transplantation
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