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Roger Reeves

Mohamed I F Shariff, Jin U Kim, Nimzing G Ladep, Mary M E Crossey, Larry K Koomson, Abigail Zabron, Helen Reeves, Matthew Cramp, Stephen Ryder, Shaun Greer, I Jane Cox, Roger Williams, Elaine Holmes, Kathryn Nash, Simon D Taylor-Robinson
BACKGROUND: Discriminatory metabolic profiles have been described in urinary (1)H nuclear magnetic resonance (NMR) spectroscopy studies of African patients with hepatocellular carcinoma (HCC). This study aimed to assess similarities in a UK cohort, where there is a greater etiological diversity. METHODS: Urine from cirrhosis and HCC patients was analyzed using a 600 MHz (1)H NMR system. Multivariate analysis and median group MR spectra comparison identified metabolite alterations between groups...
September 2016: Journal of Clinical and Experimental Hepatology
Jodi Taylor, Sarah Black, Stephen J Brett, Kim Kirby, Jerry P Nolan, Barnaby C Reeves, Maria Robinson, Chris A Rogers, Lauren J Scott, Adrian South, Elizabeth A Stokes, Matthew Thomas, Sarah Voss, Sarah Wordsworth, Jonathan R Benger
Health outcomes after out of hospital cardiac arrest (OHCA) are extremely poor, with only 7-9% of patients in the United Kingdom (UK) surviving to hospital discharge. Currently emergency medical services (EMS) use either tracheal intubation or newer supraglottic airway devices (SGAs) to provide advanced airway management during OHCA. Equipoise between the two techniques has led to calls for a well-designed randomised controlled trial. The primary objective of the AIRWAYS-2 trial is to assess whether the clinical effectiveness of the i-gel, a second-generation SGA, is superior to tracheal intubation in the initial airway management of OHCA patients in the UK...
September 30, 2016: Resuscitation
William Hollingworth, Mousumi Biswas, Rachel L Maishman, Mark J Dayer, Theresa McDonagh, Sarah Purdy, Barnaby C Reeves, Chris A Rogers, Rachael Williams, Maria Pufulete
BACKGROUND: Evidence on the economic impact of heart failure (HF) is vital in order to predict the cost-effectiveness of novel interventions. We estimate the health system costs of HF during the last five years of life. METHODS: We used linked primary care and mortality data accessed through the Clinical Practice Research Datalink (CPRD) to identify 1555 adults in England who died with HF in 2012/13. We used CPRD and linked Hospital Episode Statistics to estimate the cost of medications, primary and hospital healthcare...
September 15, 2016: International Journal of Cardiology
Barnaby C Reeves, Katie Pike, Chris A Rogers, Rachel Cm Brierley, Elizabeth A Stokes, Sarah Wordsworth, Rachel L Nash, Alice Miles, Andrew D Mumford, Alan Cohen, Gianni D Angelini, Gavin J Murphy
BACKGROUND: Uncertainty about optimal red blood cell transfusion thresholds in cardiac surgery is reflected in widely varying transfusion rates between surgeons and cardiac centres. OBJECTIVE: To test the hypothesis that a restrictive compared with a liberal threshold for red blood cell transfusion after cardiac surgery reduces post-operative morbidity and health-care costs. DESIGN: Multicentre, parallel randomised controlled trial and within-trial cost-utility analysis from a UK NHS and Personal Social Services perspective...
August 2016: Health Technology Assessment: HTA
Björg Pálsdóttir, Jean Barry, Andreia Bruno, Hugh Barr, Amy Clithero, Nadia Cobb, Jan De Maeseneer, Elsie Kiguli-Malwadde, André-Jacques Neusy, Scott Reeves, Roger Strasser, Paul Worley
Across the globe, a "fit for purpose" health professional workforce is needed to meet health needs and challenges while capitalizing on existing resources and strengths of communities. However, the socio-economic impact of educating and deploying a fit for purpose health workforce can be challenging to evaluate. In this paper, we provide a brief overview of six promising strategies and interventions that provide context-relevant health professional education within the health system. The strategies focused on in the paper are:1...
2016: Human Resources for Health
Barnaby C Reeves, Lauren J Scott, Jodi Taylor, Simon P Harding, Tunde Peto, Alyson Muldrew, Ruth E Hogg, Sarah Wordsworth, Nicola Mills, Dermot O'Reilly, Chris A Rogers, Usha Chakravarthy
OBJECTIVES: To compare the ability of ophthalmologists versus optometrists to correctly classify retinal lesions due to neovascular age-related macular degeneration (nAMD). DESIGN: Randomised balanced incomplete block trial. Optometrists in the community and ophthalmologists in the Hospital Eye Service classified lesions from vignettes comprising clinical information, colour fundus photographs and optical coherence tomographic images. Participants' classifications were validated against experts' classifications (reference standard)...
2016: BMJ Open
Marie-Claude Potier, Roger H Reeves
No abstract text is available yet for this article.
2016: Frontiers in Behavioral Neuroscience
Ozanna Burnicka-Turek, Jeffrey D Steimle, Wenhui Huang, Lindsay Felker, Anna Kamp, Junghun Kweon, Michael Peterson, Roger H Reeves, Cheryl L Maslen, Peter J Gruber, Xinan H Yang, Jay Shendure, Ivan P Moskowitz
Atrioventricular septal defects (AVSDs) are a common severe form of congenital heart disease (CHD). In this study we identified deleterious non-synonymous mutations in two cilia genes, Dnah11 and Mks1, in independent ENU-induced mouse mutant lines with heritable recessive AVSDs by whole-exome sequencing (WES). Cilia are required for left/right body axis determination and second heart field (SHF) Hedgehog (Hh) signaling, and we find that cilia mutations affect these requirements differentially. Dnah11(avc4) did not disrupt SHF Hh signaling and caused AVSDs only concurrently with heterotaxy, a left/right axis abnormality...
June 23, 2016: Human Molecular Genetics
Karen D Coulman, Noah Howes, James Hopkins, Katie Whale, Katy Chalmers, Sara Brookes, Alex Nicholson, Jelena Savovic, Yasmin Ferguson, Amanda Owen-Smith, Jane Blazeby, Jane Blazeby, Richard Welbourn, James Byrne, Jenny Donovan, Barnaby C Reeves, Sarah Wordsworth, Robert Andrews, Janice L Thompson, Graziella Mazza, Chris A Rogers
BACKGROUND: A comprehensive evaluation of bariatric surgery is required to inform decision-making. This will include measures of benefit and risk. It is possible that stakeholders involved with surgery value these outcomes differently, although this has not previously been explored. This study aimed to investigate and compare how professionals and patients prioritise outcomes of bariatric surgery. METHODS: Systematic reviews and qualitative interviews created an exhaustive list of outcomes...
May 2, 2016: Obesity Surgery
David A Bush, Jason C Smith, Jerry D Slater, Michael L Volk, Mark E Reeves, Jason Cheng, Roger Grove, Michael E de Vera
PURPOSE: To describe results of a planned interim analysis of a prospective, randomized clinical trial developed to compare treatment outcomes among patients with newly diagnosed hepatocellular carcinoma (HCC). METHODS AND MATERIALS: Eligible subjects had either clinical or pathologic diagnosis of HCC and met either Milan or San Francisco transplant criteria. Patients were randomly assigned to transarterial chemoembolization (TACE) or to proton beam radiation therapy...
May 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Alexander J E Foss, Lauren J Scott, Chris A Rogers, Barney C Reeves, Faruque Ghanchi, Jonathan Gibson, Usha Chakravarthy
PURPOSE: To describe changes in intraocular pressure (IOP) in the 'alternative treatments to Inhibit VEGF in Age-related choroidal Neovascularisation (IVAN)' trial (registered as ISRCTN92166560). DESIGN: Randomised controlled clinical trial with factorial design. PARTICIPANTS: Patients (n=610) with treatment naïve neovascular age-related macular degeneration were enrolled and randomly assigned to receive either ranibizumab or bevacizumab and to two regimens, namely monthly (continuous) or as needed (discontinuous) treatment...
April 12, 2016: British Journal of Ophthalmology
Huiqing Li, Sarah Edie, Donna Klinedinst, Jun Seop Jeong, Seth Blackshaw, Cheryl L Maslen, Roger H Reeves
Down syndrome (DS) is a significant risk factor for congenital heart disease (CHD), increasing the incidence 50 times over the general population. However, half of people with DS have a normal heart and thus trisomy 21 is not sufficient to cause CHD by itself. Ts65Dn mice are trisomic for orthologs of >100 Hsa21 genes, and their heart defect frequency is significantly higher than their euploid littermates. Introduction of a null allele of Creld1 into Ts65Dn increases the penetrance of heart defects significantly...
June 2016: Genetics
Yousef Al-Shraideh, Umar Farooq, Hany El-Hennawy, Alan C Farney, Amudha Palanisamy, Jeffrey Rogers, Giuseppe Orlando, Muhammad Khan, Amber Reeves-Daniel, William Doares, Scott Kaczmorski, Michael D Gautreaux, Samy S Iskandar, Gloria Hairston, Elizabeth Brim, Margaret Mangus, Robert J Stratta
AIM: To compare outcomes between single and dual en bloc (EB) kidney transplants (KT) from small pediatric donors. METHODS: Monocentric nonprospective review of KTs from pediatric donors ≤ 5 years of age. Dual EB KT was defined as keeping both donor kidneys attached to the inferior vena cava and aorta, which were then used as venous and arterial conduits for the subsequent transplant into a single recipient. Donor age was less useful than either donor weight or kidney size in decision-making for kidney utilization as kidneys from donors < 8 kg or kidneys < 6 cm in length were not transplanted...
March 24, 2016: World Journal of Transplantation
Robert J Stratta, Alan C Farney, Giuseppe Orlando, Umar Farooq, Yousef Al-Shraideh, Amudha Palanisamy, Amber Reeves-Daniel, William Doares, Scott Kaczmorski, Michael D Gautreaux, Samy S Iskandar, Gloria Hairston, Elizabeth Brim, Margaret Mangus, Hany El-Hennawy, Muhammad Khan, Jeffrey Rogers
BACKGROUND: The need to expand the organ donor pool remains a formidable challenge in kidney transplantation (KT). The use of expanded criteria donors (ECDs) represents one approach, but kidney discard rates are high because of concerns regarding overall quality. Dual KT (DKT) may reduce organ discard and optimize the use of kidneys from marginal donors. STUDY DESIGN: We conducted a single-center retrospective review of outcomes in adult recipients of DKTs from adult marginal deceased donors (DD) defined by limited renal functional capacity...
April 2016: Clinical Transplantation
Annan Yang, Duane Currier, Jennifer L Poitras, Roger H Reeves
Down syndrome (DS) is a genetic disorder caused by the presence of an extra copy of human chromosome 21 (Hsa21). People with DS display multiple clinical traits as a result of the dosage imbalance of several hundred genes. While many outcomes of trisomy are deleterious, epidemiological studies have shown a significant risk reduction for most solid tumors in DS. Reduced tumor incidence has also been demonstrated in functional studies using trisomic DS mouse models. Therefore, it was interesting to find that Ts1Rhr trisomic mice developed more papillomas than did their euploid littermates in a DMBA-TPA chemical carcinogenesis paradigm...
2016: PloS One
Lucy Ellis, Gavin J Murphy, Lucy Culliford, Lucy Dreyer, Gemma Clayton, Richard Downes, Eamonn Nicholson, Serban Stoica, Barnaby C Reeves, Chris A Rogers
BACKGROUND: Indices of global tissue oxygen delivery and utilization such as mixed venous oxygen saturation, serum lactate concentration, and arterial hematocrit are commonly used to determine the adequacy of tissue oxygenation during cardiopulmonary bypass (CPB). However, these global measures may not accurately reflect regional tissue oxygenation and ischemic organ injury remains a common and serious complication of CPB. Near-infrared spectroscopy (NIRS) is a noninvasive technology that measures regional tissue oxygenation...
2015: JMIR Research Protocols
Thomas W Johnson, Andrew D Mumford, Lauren J Scott, Stuart Mundell, Mark Butler, Julian W Strange, Chris A Rogers, Barnaby C Reeves, Andreas Baumbach
BACKGROUND: Rapid coronary recanalization following ST-elevation myocardial infarction (STEMI) requires effective anti-platelet and anti-thrombotic therapies. This study tested the impact of door to end of procedure ('door-to-end') time and baseline platelet activity on platelet inhibition within 24hours post-STEMI. METHODS AND FINDINGS: 108 patients, treated with prasugrel and procedural bivalirudin, underwent Multiplate® platelet function testing at baseline, 0, 1, 2 and 24hours post-procedure...
2015: PloS One
Barry I Freedman, Stephen O Pastan, Ajay K Israni, David Schladt, Bruce A Julian, Michael D Gautreaux, Vera Hauptfeld, Robert A Bray, Howard M Gebel, Allan D Kirk, Robert S Gaston, Jeffrey Rogers, Alan C Farney, Giuseppe Orlando, Robert J Stratta, Sumit Mohan, Lijun Ma, Carl D Langefeld, Donald W Bowden, Pamela J Hicks, Nicholette D Palmer, Amudha Palanisamy, Amber M Reeves-Daniel, W Mark Brown, Jasmin Divers
BACKGROUND: Two apolipoprotein L1 gene (APOL1) renal-risk variants in donors and African American (AA) recipient race are associated with worse allograft survival in deceased-donor kidney transplantation (DDKT) from AA donors. To detect other factors impacting allograft survival from deceased AA kidney donors, APOL1 renal-risk variants were genotyped in additional AA kidney donors. METHODS: The APOL1 genotypes were linked to outcomes in 478 newly analyzed DDKTs in the Scientific Registry of Transplant Recipients...
January 2016: Transplantation
Steven Cranfield, Jane Hendy, Barnaby Reeves, Andrew Hutchings, Simon Collin, Naomi Fulop
PURPOSE: The purpose of this paper is to better understand how and why adoption and implementation of healthcare IT innovations occur. The authors examine two IT applications, computerised physician order entry (CPOE) and picture archiving and communication systems (PACS) at the meso and micro levels, within the context of the National Programme for IT in the English National Health Service (NHS). DESIGN/METHODOLOGY/APPROACH: To analyse these multi-level dynamics, the authors blend Rogers' diffusion of innovations theory (DoIT) with Webster's sociological critique of technological innovation in medicine and healthcare systems to illuminate a wider range of interacting factors...
2015: Journal of Health Organization and Management
Nandini Singh, Tara Dutka, Roger H Reeves, Joan T Richtsmeier
BACKGROUND: In Ts65Dn, a mouse model of Down syndrome (DS), brain and craniofacial abnormalities that parallel those in people with DS are linked to an attenuated cellular response to sonic hedgehog (SHH) signaling. If a similarly reduced response to SHH occurs in all trisomic cells, then chronic up-regulation of the pathway might have a positive effect on development in trisomic mice, resulting in amelioration of the craniofacial anomalies. RESULTS: We crossed Ts65Dn with Ptch1(tm1Mps/+) mice and quantified the craniofacial morphology of Ts65Dn;Ptch(+/-) offspring to assess whether a chronic up-regulation of the SHH pathway rescued DS-related anomalies...
February 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
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