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"Perinatal loss"

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https://www.readbyqxmd.com/read/28549467/the-prediction-diagnosis-and-management-of-complications-in-monochorionic-twin-pregnancies-the-ommit-optimal-management-of-monochorionic-twins-study
#1
Fiona L Mackie, R Katie Morris, Mark D Kilby
BACKGROUND: Monochorionic twin pregnancies are at increased risk of complications due to sharing a single placenta and potentially developing unbalanced vascular anastomoses. Complications include twin-twin transfusion syndrome (TTTS) which affects 10-15% monochorionic twins, and if untreated has a 70-90% perinatal loss rate. We are currently unable to predict which twins will develop complications or to what severity. We have previously shown differences in angiogenic and placental growth factors in maternal blood in pregnancies complicated by TTTS compared to twin pregnancies not complicated by TTTS but matched for gestation...
May 26, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28536504/thyroid-hormone-induces-pgc-1%C3%AE-during-dendritic-outgrowth-in-mouse-cerebellar-purkinje-cells
#2
Tetsu Hatsukano, Junko Kurisu, Kansai Fukumitsu, Kazuto Fujishima, Mineko Kengaku
Thyroid hormone 3,3',5-Triiodo-L-thyronine (T3) is essential for proper brain development. Perinatal loss of T3 causes severe growth defects in neurons and glia, including strong inhibition of dendrite formation in Purkinje cells in the cerebellar cortex. Here we show that T3 promotes dendritic outgrowth of Purkinje cells through induction of peroxisome proliferator-activated receptor gamma (PPARγ) co-activator 1α (PGC-1α), a master regulator of mitochondrial biogenesis. PGC-1α expression in Purkinje cells is upregulated during dendritic outgrowth in normal mice, while it is significantly retarded in hypothyroid mice or in cultures depleted of T3...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28507639/comparative-assessment-of-women-s-reproductive-health-in-the-areas-bordering-with-the-aral-sea-region
#3
Yasminur G Turdybekova, Irina L Kopobayeva, Berikbay Zh Kultanov
AIM: We examined 435 women of Aktobe region and 328 women of South Kazakhstan region, living in areas bordering the Aral Sea region during the study and comparative assessment of the impact of climatic and anthropogenic factors of Aral region on the reproductive health of the female population. MATERIAL AND METHODS: The survey based on the comprehensive clinical-functional and laboratory studies accounting the regional and environmental ecological factors. Survey subject was the area of 2 settlements of Aktobe region and 1 settlement of South Kazakhstan region...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28436166/perinatal-loss-at-term-the-role-of-uteroplacental-and-fetal-doppler-assessment
#4
Caitriona Monaghan, Julia Binder, Baskaran Thilaganathan, José Morales-Roselló, Asma Khalil
OBJECTIVE: To examine the association of uterine artery (UtA) Doppler indices and cerebroplacental ratio (CPR) on perinatal outcome at term. METHODS: This retrospective cohort study conducted in a single tertiary referral centre included all singleton pregnancies undergoing ultrasound assessment in the third trimester, which subsequently delivered at term. Fetal biometry and Dopplers including the umbilical artery (UA), middle cerebral artery (MCA) and uterine artery were recorded...
April 24, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28150444/the-influence-of-chorionicity-and-gestational-age-at-single-fetal-loss-on-the-risk-of-preterm-birth-in-twin-pregnancies-analysis-of-the-stork-multiple-pregnancy-cohort
#5
Francesco D'Antonio, Basky Thilaganathan, Tiran Dias, Asma Khalil
BACKGROUND: Single intrauterine death (sIUD) in twin pregnancies is associated with a significant risk of co-twin demise and preterm birth (PTB), especially in monochorionic (MC) twins. However, it is yet to be established whether the gestational age at loss may influence the pregnancy outcome. The aim of this study was to explore the risk of PTB according to the gestational age at the diagnosis of sIUD. METHODS: A cohort study of all twin pregnancies from a large regional network of 9 hospitals over a ten-year period...
February 2, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28137987/diagnostic-performance-of-placental-growth-factor-in-women-with-suspected-preeclampsia-attending-antenatal-facilities-in-maputo-mozambique
#6
U Vivian Ukah, Francisco Mbofana, Beatriz Manriquez Rocha, Osvaldo Loquiha, Chishamiso Mudenyanga, Momade Usta, Marilena Urso, Sharla Drebit, Laura A Magee, Peter von Dadelszen
In well-resourced settings, reduced circulating maternal-free placental growth factor (PlGF) aids in either predicting or confirming the diagnosis of preeclampsia, fetal growth restriction, stillbirth, preterm birth, and delivery within 14 days of testing when preeclampsia is suspected. This blinded, prospective cohort study of maternal plasma PlGF in women with suspected preeclampsia was conducted in antenatal clinics in Maputo, Mozambique. The primary outcome was the clinic-to-delivery interval. Other outcomes included: confirmed diagnosis of preeclampsia, transfer to higher care, mode of delivery, intrauterine fetal death, preterm birth, and low birth weight...
March 2017: Hypertension
https://www.readbyqxmd.com/read/28126057/depressive-symptomatology-and-grief-in-spanish-women-who-have-suffered-a-perinatal-loss
#7
Isabel Ridaura, Eva Penelo, Rosa M Raich
BACKGROUND: Perinatal grief differs from other types of mourning. Two goals were set: to describe the progression of the process of grief and the symptoms of depression throughout the year following perinatal loss, and to study its association with socio-economic and obstetric factors. METHOD: The study involved the participation of 70 women who had suffered a medical termination of pregnancy or a prenatal/postnatal death. Three assessments were made after the loss (after 1 month, 6 months and 1 year) with the Perinatal Grief Scale (PGS) to assess grief and the Beck Depression Inventory (BDI) for depressive symptomatology...
February 2017: Psicothema
https://www.readbyqxmd.com/read/28100569/multiple-pregnancy-in-a-primigravida-with-uncorrected-pentalogy-of-fallot
#8
Pamela Partana, Jarrod Kah Hwee Tan, Ju Le Tan, Lay Kok Tan
Pentalogy of Fallot is a cyanotic congenital heart disease that has guarded prognosis without surgical intervention in infancy. Women with uncorrected defects rarely survive into childbearing age and pregnancy in this group is associated with a high rate of perinatal loss. Physiological cardiovascular changes in pregnancy can lead to maternal haemodynamic instability with subsequent adverse cardiac sequelae with or without fetal decompensation. Optimum management and pregnancy outcomes in mother with uncorrected Pentalogy of Fallot and twin pregnancy have not been described in the literature...
January 18, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28056861/-not-just-a-normal-mum-a-qualitative-investigation-of-a-support-service-for-women-who-are-pregnant-subsequent-to-perinatal-loss
#9
Pamela Meredith, Trish Wilson, Grace Branjerdporn, Jenny Strong, Laura Desha
BACKGROUND: Following previous perinatal loss, women in a subsequent pregnancy may experience heightened emotions, such as anxiety and fear, with a range of longer-term implications. To support these women, the Mater Mothers' Bereavement Support Service in Brisbane, Australia, developed a Pregnancy After Loss Clinic (PALC) as a specialised hospital-based service. The present study investigated the experiences of mothers with previous perinatal loss in relation to: (a) their subsequent pregnancy-to-birth journey, and (b) the PALC service...
January 5, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28002990/translation-and-validation-of-the-perinatal-grief-scale-in-a-sample-of-greek-women-with-perinatal-loss-during-the-1st-and-2nd-trimester-of-pregnancy
#10
Elissavet Maniatelli, Yiannis Zervas, Panagiotis Halvatsiotis, Eirini Tsartsara, Chara Tzavara, Despina D Briana, Nikolaos Salakos
OBJECTIVE: To translate and validate the Perinatal Grief Scale (PGS) (short version) in a sample of Greek women with perinatal loss during the first and second trimester of pregnancy. METHODS: One hundred seventy-six women were approached a few hours after the loss. Along with the PGS, three more questionnaires were completed: the Edinburgh Postnatal Depression Scale (EPDS), the Hospital Anxiety and Depression Scale (HADS) and the State-Trait Anxiety Inventory (STAI), in order to assess the convergent validity of the PGS...
January 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27884847/long-term-mortality-in-mothers-with-perinatal-losses-and-risk-modification-by-surviving-children-and-attained-education-a-population-based-cohort-study
#11
Frode Halland, Nils-Halvdan Morken, Lisa A DeRoo, Kari Klungsøyr, Allen J Wilcox, Rolv Skjærven
OBJECTIVE: To assess the association between perinatal losses and mother's long-term mortality and modification by surviving children and attained education. DESIGN: A population-based cohort study. SETTING: Norwegian national registries. PARTICIPANTS: We followed 652 320 mothers with a first delivery from 1967 and completed reproduction before 2003, until 2010 or death. We excluded mothers with plural pregnancies, without information on education (0...
November 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27726479/death-of-one-twin-during-the-perinatal-period-an-interpretative-phenomenological-analysis
#12
Sarah Meaney, Paul Corcoran, Keelin O'Donoghue
BACKGROUND: Perinatal death is one of the most difficult bereavements due to the shock and profound grief experienced by parents. It has been established that such bereavement has a life-lasting impact. Twin pregnancy is associated with increased perinatal risk, with higher rates of perinatal mortality than in singleton pregnancy. OBJECTIVES: To date, few studies have examined the effect of the loss of one twin diagnosed with a congenital abnormality during pregnancy...
March 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27706858/complications-of-intrauterine-intravascular-blood-transfusions-lessons-learned-after-1678-procedures
#13
Carolien Zwiers, Irene T M Lindenburg, Frans J C M Klumper, Masja de Haas, Dick Oepkes, Inge L van Kamp
BACKGROUND: maternal alloimmunization to fetal red blood cell antigens is a major cause of fetal anemia, which in untreated cases can lead to hydrops and perinatal death. The cornerstone of the management during pregnancy is intrauterine intravascular blood transfusion. Although this procedure is considered to be relatively safe, (procedure-related) complications continue to occur. OBJECTIVES: to evaluate procedure-related complications and perinatal loss rates of intrauterine transfusion and changes over time, aiming to identify factors leading to improved outcome...
October 5, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27680038/factors-associated-with-the-grief-after-stillbirth-a-comparative-study-between-brazilian-and-canadian-women
#14
COMPARATIVE STUDY
Gisele Ferreira Paris, Francine de Montigny, Sandra Marisa Pelloso
OBJECTIVE: To verify the association between complicated grief and sociodemographic, reproductive, mental, marital satisfaction, and professional support characteristics in women after stillbirth. METHOD: Cross-sectional study with 26 women who had stillbirth in 2013, living in the city of Maringá, Brazil, and eight women who attended the Centre d'Études et de Rechercheen Intervention Familiale at the University of Quebec en Outaouais, in Canada. The instrument was administered as an interview to a small number of mothers of infants up to three months (n=50), who did not participate in the validation study...
July 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/27631865/what-clinicians-miss-about-miscarriages-clinical-errors-in-the-treatment-of-early-term-perinatal-loss
#15
Rayna D Markin
In this article, clinical errors in the treatment of perinatal grief after a miscarriage are discussed, including (a) minimizing or avoiding painful affects related to the miscarriage, (b) assuming grief is resolved upon a subsequent healthy pregnancy, and (c) neglecting early unresolved losses that are reawakened by the loss of the pregnancy. It is argued that these unintentional errors, frequently committed by significant others in the patient's life, are similarly made by well-intentioned clinicians due to a lack of knowledge about the psychological impact of miscarriage and, moreover, an unconscious avoidance of such a common yet distressing loss...
September 2016: Psychotherapy
https://www.readbyqxmd.com/read/27620393/the-chips-randomized-controlled-trial-control-of-hypertension-in-pregnancy-study-is-severe-hypertension-just-an-elevated-blood-pressure
#16
Laura A Magee, Peter von Dadelszen, Joel Singer, Terry Lee, Evelyne Rey, Susan Ross, Elizabeth Asztalos, Kellie E Murphy, Jennifer Menzies, Johanna Sanchez, Amiram Gafni, Michael Helewa, Eileen Hutton, Gideon Koren, Shoo K Lee, Alexander G Logan, Wessel Ganzevoort, Ross Welch, Jim G Thornton, Jean-Marie Moutquin
To determine whether clinical outcomes differed by occurrence of severe hypertension in the international CHIPS trial (Control of Hypertension in Pregnancy Study), adjusting for the interventions of "less tight" (target diastolic blood pressure [dBP] 100 mm Hg) versus "tight" control (target dBP 85 mm Hg). In this post-hoc analysis of CHIPS data from 987 women with nonsevere nonproteinuric preexisting or gestational hypertension, mixed effects logistic regression was used to compare the following outcomes according to occurrence of severe hypertension, adjusting for allocated group and the influence of baseline factors: CHIPS primary (perinatal loss or high-level neonatal care for >48 hours) and secondary outcomes (serious maternal complications), birth weight <10th percentile, preeclampsia, delivery at <34 or <37 weeks, platelets <100×10(9)/L, elevated liver enzymes with symptoms, maternal length of stay ≥10 days, and maternal readmission before 6 weeks postpartum...
November 2016: Hypertension
https://www.readbyqxmd.com/read/27607765/grief-traumatic-stress-and-posttraumatic-growth-in-women-who-have-experienced-pregnancy-loss
#17
Daniel Jay Krosch, Jane Shakespeare-Finch
Objective: Pregnancy loss is common and can be devastating for those who experience it. However, a historical focus on negative outcomes, and grief in particular, has rendered an incomplete portrait of both the gravity of the loss, and the potential for growth in its wake. Consistent with contemporary models of growth following bereavement, this study explored the occurrence of posttraumatic growth following pregnancy loss and further assessed the role of core belief disruptions and common loss context factors across perinatal grief, posttraumatic stress symptoms, and posttraumatic growth...
September 8, 2016: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/27573073/the-presence-and-predictors-of-complicated-grief-symptoms-in-perinatally-bereaved-mothers-from-a-bereavement-support-organization
#18
Margaret McSpedden, Barbara Mullan, Louise Sharpe, Lauren J Breen, Elizabeth A Lobb
The present study investigated the presence and possible predictors of complicated grief symptoms in perinatally bereaved mothers (N = 121) up to 5 years postbereavement. The presence of complicated grief scores in the clinical range was 12.4%, which is higher than in many other bereaved populations, and the presence of other living children may protect against the development of complicated grief symptoms. The majority of the women were able to negotiate a perinatal loss without developing complicated grief; however, there remains an important group of women who up to 5 years later score in the clinical range for complicated grief symptoms...
February 2017: Death Studies
https://www.readbyqxmd.com/read/27562824/are-participants-in-face-to-face-and-internet-support-groups-the-same-comparison-of-demographics-and-depression-levels-among-women-bereaved-by-stillbirth
#19
Katherine J Gold, Margaret M Normandin, Martha E Boggs
Support groups can help individuals cope with difficult health situations but have been understudied for women with perinatal bereavement. An early study suggested those using internet support groups had high rates of positive depression screens, raising the question whether these users were more symptomatic than those in similar face-to-face support groups. We therefore conducted two convenience sample surveys of women bereaved by perinatal loss, one looking at use of online support groups and the other in-person support groups...
August 25, 2016: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27543968/experiences-of-termination-of-pregnancy-for-a-fetal-anomaly-a-qualitative-study-of-virtual-community-messages
#20
Tommy Carlsson, Gunnar Bergman, Anna-Malin Karlsson, Barbro Wadensten, Elisabet Mattsson
OBJECTIVE: to explore experiences described by posters in Swedish virtual communities before, during and after termination of pregnancy due to a fetal anomaly. DESIGN: cross-sectional qualitative study of messages in virtual communities. The messages were purposefully selected in 2014 and analyzed with inductive qualitative manifest content analysis. SETTING: two large and active Swedish virtual communities. SAMPLE: 1623 messages from 122 posters (112 females, 1 male, and 9 did not disclose their sex), written between 2008 and 2014...
October 2016: Midwifery
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