Bettina P Mihalas, Gerard H Pieper, Mansour Aboelenain, Lucy Munro, Vlastimil Srsen, Cerys E Currie, David A Kelly, Geraldine M Hartshorne, Evelyn E Telfer, Andrew D McAinsh, Richard A Anderson, Adele L Marston
Aneuploid human eggs (oocytes) are a major cause of infertility, miscarriage, and chromosomal disorders. Such aneuploidies increase greatly as women age, with defective linkages between sister chromatids (cohesion) in meiosis as a common cause. We found that loss of a specific pool of the cohesin protector protein, shugoshin 2 (SGO2), may contribute to this phenomenon. Our data indicate that SGO2 preserves sister chromatid cohesion in meiosis by protecting a "cohesin bridge" between sister chromatids. In human oocytes, SGO2 localizes to both sub-centromere cups and the pericentromeric bridge, which spans the sister chromatid junction...
December 14, 2023: Current Biology: CB