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Dietary nitrate

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https://www.readbyqxmd.com/read/29892479/a-review-of-plant-based-diets-to-prevent-and-treat-heart-failure
#1
REVIEW
Conor P Kerley
Evidence supporting the role of nutrition in heart failure (HF) incidence and severity is growing. A comprehensive search of online databases was conducted using relevant keywords to identify human studies including diet and HF. Several plant-based diets have consistently been associated with decreased HF incidence and severity, notably the Dietary Approaches to Stop Hypertension (DASH) and Mediterranean diets. Several other plant-based dietary patterns, including low-fat diets and the rice diet, also show promise...
May 2018: Cardiac failure review
https://www.readbyqxmd.com/read/29873077/anatomical-subsite-can-modify-the-association-between-meat-and-meat-compounds-and-risk-of-colorectal-adenocarcinoma-findings-from-three-large-us-cohorts
#2
Arash Etemadi, Christian C Abnet, Barry I Graubard, Laura Beane- Freeman, Neal D Freedman, Linda Liao, Sanford M Dawsey, Rashmi Sinha
Distal and proximal colon tumors have distinct incidence trends and embryonic origins; whether these sub-sites have distinct susceptibilities to known risk factors is unclear. We used pooled data from 407,270 participants in three US-based studies, with overall median follow-up of 13.8 years. We used adjusted Cox models to analyze the association between dietary intakes (from diet history questionnaire) of total, processed and unprocessed red meat; total white meat, poultry and fish; and meat-related compounds: heme iron, nitrate, nitrite, the heterocyclic amines (HCAs), and benzo(a)pyrene (B(a)P) and incidence of colorectal cancer subsites...
June 6, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29866218/subchronic-oral-toxicity-evaluation-of-lanthanum-a-90-day-repeated-dose-study-in-rats
#3
Hai Qin Fang, Zhou Yu, Yuan Zhi, Jin Fang, Chen Xi Li, Yi Mei Wang, Shuang Qing Peng, Xu Dong Jia
OBJECTIVE: The present study was undertaken to evaluate the subchronic toxicity of lanthanum and to determine the no observed adverse effect level (NOAEL), which is a critical factor in the establishment of an acceptable dietary intake (ADI). METHODS: In accordance with the Organization for Economic Co-operation and Development (OECD) testing guidelines, lanthanum nitrate was administered once daily by gavage to Sprague-Dawley (SD) rats at dose levels of 0, 1.5, 6...
May 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29807159/nitrate-responsive-oral-microbiome-modulates-nitric-oxide-homeostasis-and-blood-pressure-in-humans
#4
Anni Vanhatalo, Jamie R Blackwell, Joanna L'Heureux, David W Williams, Ann Smith, Mark van der Giezen, Paul G Winyard, James Kelly, Andrew M Jones
Imbalances in the oral microbial community have been associated with reduced cardiovascular and metabolic health. A possible mechanism linking the oral microbiota to health is the nitrate (NO3 - )-nitrite (NO2 - )-nitric oxide (NO) pathway, which relies on oral bacteria to reduce NO3 - to NO2 - . NO (generated from both NO2 - and L-arginine) regulates vascular endothelial function and therefore blood pressure (BP). By sequencing bacterial 16S rRNA genes we examined the relationships between the oral microbiome and physiological indices of NO bioavailability and possible changes in these variables following 10 days of NO3 - (12mmol/d) and placebo supplementation in young (18-22yrs) and old (70-79yrs) normotensive humans (n=18)...
May 25, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29795728/effects-of-single-dose-dietary-nitrate-on-oxygen-consumption-during-and-after-maximal-and-submaximal-exercise-in-healthy-humans-a-pilot-study
#5
Genevieve M Kocoloski, Anne R Crecelius
Dietary nitrate (NO3 - ) has been shown to reduce oxygen consumption (VO2 ) during moderate to high-intensity (e.g. time to fatigue, time trials) exercise and often in trained athletes. However, less is known regarding prolonged exercise and the potential impact of NO3 - on post-exercise excess oxygen consumption (EPOC), particularly in untrained individuals, who may have different metabolic goals during exercise than trained individuals. We tested the hypothesis that acute nitrate supplementation in the form of beet root juice will significantly decrease both VO2 during maximal exercise and EPOC in both maximal and submaximal exercise trials...
2018: International Journal of Exercise Science
https://www.readbyqxmd.com/read/29775547/acute-dietary-nitrate-supplementation-does-not-attenuate-oxidative-stress-or-the-hemodynamic-response-during-submaximal-exercise-in-hypobaric-hypoxia
#6
Colin R Carriker, Paige Rombach, Brooke M Stevens, Roger A Vaughan, Ann L Gibson
PURPOSE: To investigate changes in oxidative stress, arterial oxygen saturation (SaO2), blood pressure (BP), and heart rate (HR) while exercising in hypobaric hypoxia following acute dietary nitrate supplementation. METHODS: Nine well-trained (60.8±7.8 ml/kg/min) males (29±7 years) visited the lab on 3 occasions, each separated by 1 week. Visit 1 included a maximal aerobic cycling test (VO2max) and 5 five-minute increasing intensity exercise bouts in a normobaric environment (1600m)...
May 18, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29769113/thinking-beyond-opisthorchis-viverrini-for-risk-of-cholangiocarcinoma-in-the-lower-mekong-region-a-systematic-review-and-meta-analysis
#7
REVIEW
Jennifer A Steele, Carsten H Richter, Pierre Echaubard, Parichat Saenna, Virginia Stout, Paiboon Sithithaworn, Bruce A Wilcox
BACKGROUND: Cholangiocarcinoma (CCA) is a fatal bile duct cancer associated with infection by the liver fluke, Opisthorchis viverrini, in the lower Mekong region. Numerous public health interventions have focused on reducing exposure to O. viverrini, but incidence of CCA in the region remains high. While this may indicate the inefficacy of public health interventions due to complex social and cultural factors, it may further indicate other risk factors or interactions with the parasite are important in pathogenesis of CCA...
May 17, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29766294/influence-of-dietary-nitrate-supplementation-on-local-sweating-and-cutaneous-vascular-responses-during-exercise-in-a-hot-environment
#8
Tatsuro Amano, Dai Okushima, Brynmor C Breese, Stephen J Bailey, Shunsaku Koga, Narihiko Kondo
PURPOSE: We investigated the influence of inorganic nitrate ([Formula: see text]) supplementation on local sweating and cutaneous vascular responses during exercise in hot conditions. METHOD: Eight healthy, young subjects were assigned in a randomized, double-blind, crossover design to receive [Formula: see text]-rich beetroot (BR) juice (140 mL/day, containing ~ 8 mmol of [Formula: see text]) and [Formula: see text]-depleted placebo (PL) juice (140 mL/day, containing ~ 0...
May 15, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29763679/maternal-dietary-nitrate-intake-and-risk-of-neural-tube-defects-a-systematic-review-and-dose-response-meta-analysis
#9
REVIEW
Nader Rahimi Kakavandi, Amin Hasanvand, Mahmoud Ghazi-Khansari, Ahmad Habibian Sezavar, Hassan Nabizadeh, Mohammad Parohan
Despite growing evidence for the potential teratogenicity of nitrate, knowledge about the dose-response relationship of dietary nitrate intake and risk of specific birth defects such as neural tube defects (NTDs) is limited. Therefore, the aim of this meta-analysis was to synthesize the knowledge about the dose-response relation between maternal dietary nitrate intake and the risk of NTDs. We conducted a systematic search in PubMed, ISI Web of Science and Scopus up to February 2018 for observational studies...
May 12, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29758485/isolation-characterization-and-strain-selection-of-a-paenibacillus-species-for-use-as-a-probiotic-to-aid-in-ruminal-methane-mitigation-nitrate-nitrite-detoxification-and-food-safety
#10
Elizabeth A Latham, William E Pinchak, Julian Trachsel, Heather K Allen, Todd R Callaway, David J Nisbet, Robin C Anderson
The effects of dietary nitrate and Paenibacillus 79R4 (79R4), a denitrifying bacterium, when co-administered as a probiotic, on methane emissions, nitrate and nitrite-metabolizing capacity and fermentation characteristics were studied in vitro. Mixed populations of rumen microbes inoculated with 79R4 metabolized all levels of nitrite studied after 24 h in vitro incubation. Results from in vitro simulations resulted in up to 2 log10 colony forming unit reductions in E. coli O157:H7 and Campylobacter jejuni when these were co-cultured with 79R4...
April 30, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29745362/does-dietary-nitrate-say-no-to-cardiovascular-ageing-current-evidence-and-implications-for-research
#11
Mario Siervo, Filippo Scialò, Oliver M Shannon, Blossom C M Stephan, Ammar W Ashor
CVD are characterised by a multi-factorial pathogenesis. Key pathogenetic steps in the development of CVD are the occurrence of endothelial dysfunction and formation of atherosclerotic lesions. Reduced nitric oxide (NO) bioavailability is a primary event in the initiation of the atherosclerotic cascade. NO is a free radical with multiple physiological functions including the regulation of vascular resistance, coagulation, immunity and oxidative metabolism. The synthesis of NO proceeds via two distinct pathways identified as enzymatic and non-enzymatic...
May 2018: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29727405/nitrate-supplement-benefits-contractile-forces-in-fatigued-but-not-unfatigued-muscle
#12
Neale A Tillin, Sarah Moudy, Kirsty M Nourse, Christopher J Tyler
PURPOSE: Evidence suggests dietary nitrate supplementation enhances low-frequency (≤20 Hz) involuntary, but not voluntary, forces in unfatigued human muscle. We investigated the hypotheses that nitrate supplementation would also attenuate low-frequency fatigue and the loss of explosive-voluntary forces in fatigued conditions. METHODS: In a counterbalanced double-blinded order, 17 male participants completed two experimental trials following 7 days of dietary supplementation with either nitrate-rich (NIT) or nitrate-depleted (PLA) beetroot juice...
April 27, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29722627/effect-of-dietary-nitrate-supplementation-on-conduit-artery-blood-flow-muscle-oxygenation-and-metabolic-rate-during-handgrip-exercise
#13
Jesse C Craig, Ryan M Broxterman, Joshua R Smith, Jason David Allen, Thomas J Barstow
Dietary nitrate supplementation has positive effects on mitochondrial and muscle contractile efficiency during large muscle mass exercise in humans, and on skeletal muscle blood flow (Q̇) in rats. However, concurrent measurement of these effects has not been performed in humans. Therefore, we assessed the influence of nitrate supplementation on Q̇ and muscle oxygenation characteristics during moderate (40%peak) and severe (85%peak) intensity handgrip exercise in a randomized, double-blind, crossover-design...
May 3, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29694703/mechanisms-underlying-blood-pressure-reduction-by-dietary-inorganic-nitrate
#14
REVIEW
Mattias Carlström, Jon O Lundberg, Eddie Weitzberg
Nitric oxide (NO) importantly contributes to cardiovascular homeostasis by regulating blood flow and maintaining endothelial integrity. Conversely, reduced NO bioavailability is a central feature during natural aging and in many cardiovascular disorders, including hypertension. The inorganic anions nitrate and nitrite are endogenously formed after oxidation of NO synthase (NOS)-derived NO and are also present in our daily diet. Knowledge accumulated over the past two decades have demonstrated that these anions can be recycled back to NO and other bioactive nitrogen oxides via serial reductions that involve oral commensal bacteria and various enzymatic systems...
April 25, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29693564/cerebral-blood-flow-measurements-in-adults-a-review-on-the-effects-of-dietary-factors-and-exercise
#15
REVIEW
Peter J Joris, Ronald P Mensink, Tanja C Adam, Thomas T Liu
Improving cerebrovascular function may be a key mechanism whereby a healthy lifestyle, of which a healthy diet combined with increased physical activity levels is a cornerstone, protects against cognitive impairments. In this respect, effects on cerebral blood flow (CBF)—a sensitive physiological marker of cerebrovascular function—are of major interest. This review summarizes the impact of specific dietary determinants and physical exercise on CBF in adults and discusses the relation between these effects with potential changes in cognitive function...
April 25, 2018: Nutrients
https://www.readbyqxmd.com/read/29693429/ergogenic-effects-of-beetroot-juice-supplementation-during-severe-intensity-exercise-in-obese-adolescents
#16
Letizia Rasica, Simone Porcelli, Mauro Marzorati, Desy Salvadego, Alessandra Vezzoli, Fiorenza Agosti, Alessandra De Col, Gabriella Tringali, Andrew M Jones, Alessandro Sartorio, Bruno Grassi
Previous studies showed a higher O2 cost of exercise, and therefore a reduced exercise tolerance, in obese patients during constant work rate (CWR) exercise compared to healthy subjects. Among the ergogenic effects of dietary nitrate (NO3 -) supplementation in sedentary healthy subjects, a reduced O2 cost and enhanced exercise tolerance have often been demonstrated. The aim of this study was to evaluate the effects of beetroot juice supplementation, rich in NO3 -, on physiological variables associated with exercise tolerance in obese adolescents...
April 25, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29686927/an-ultrasound-assessed-extraction-combined-with-ion-pair-hplc-method-and-risk-assessment-of-nitrite-and-nitrate-in-cured-meat
#17
Babiker Yagoub Abdulkair, Amin O Elzupir, Abdulaziz S Alamer
An accurate IPC-UV method was developed and validated for the determination of nitrite (NI) and nitrate (NA) in meat products. The best separation was achieved on a phenyl-hexyl column (150 mm × 4.6 mm, 3  µ m) with a mobile phase composed of 25% acetonitrile and 75% buffer (2 mM disodium hydrogen phosphate and 3 mM tetrabutylammonium bromide, pH = 4). Eluents were monitored at 205 nm. Linearity ranges were 1.86 × 10-6 -7.5  µ g·ml-1 and 0.09-5.0  µ g·ml-1 for NI and NA, respectively...
2018: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/29660828/storage-stability-of-dietary-nitrate-and-phenolic-compounds-in-beetroot-beta-vulgaris-and-arugula-eruca-sativa-juices
#18
Karen A Corleto, Jashbir Singh, G K Jayaprakasha, Bhimanagouda S Patil
Nitrate and polyphenols from the diet may enhance the production and bioavailability of nitric oxide, a radical signaling molecule critical for cardiovascular health. Understanding the stability of these bioactives in beetroot and arugula juices is important for their functions. In this study, the stability of nitrate and phenolics in beetroot and arugula juices was measured for 32 days at different temperatures (25, 4, -20, and -80 °C). The levels of nitrate were measured by reversed-phase HPLC and initial levels were found to be 4965...
May 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29628462/-long-term-dietary-nitrite-and-nitrate-deficiency-causes-metabolic-syndrome-endothelial-dysfunction-and-cardiovascular-death-in-mice
#19
Mika Kina-Tanada, Mayuko Sakanashi, Akira Arasaki, Masato Tsutsui
Nitric oxide (NO) is synthesized not only from L-arginine by NO synthases (NOSs), but also from its inert metabolites, nitrite and nitrate. Green leafy vegetables are abundant in nitrate, however whether or not a deficiency in dietary nitrite/nitrate spontaneously causes disease remains to be clarified. In this study, we tested our hypothesis that long-term dietary nitrite/nitrate deficiency induces metabolic syndrome (MetS) in mice. To this end, we prepared a low nitrite/nitrate diet (LND) consisting of an amino acid-based low nitrite/nitrate chow in which the contents of L-arginine, fat, carbohydrates, protein, and energy were identical with a regular chow, and potable ultrapure water...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
https://www.readbyqxmd.com/read/29625952/effects-of-dietary-inorganic-nitrate-supplementation-on-exercise-performance-in-patients-with-heart-failure-protocol-for-a-randomized-placebo-controlled-cross-over-trial
#20
Mary N Woessner, Itamar Levinger, Christopher Neil, Cassandra Smith, Jason D Allen
BACKGROUND: Chronic heart failure is characterized by an inability of the heart to pump enough blood to meet the demands of the body, resulting in the hallmark symptom of exercise intolerance. Chronic underperfusion of the peripheral tissues and impaired nitric oxide bioavailability have been implicated as contributors to the decrease in exercise capacity in these patients. nitric oxide bioavailability has been identified as an important mediator of exercise tolerance in healthy individuals, but there are limited studies examining the effects in patients with chronic heart failure...
April 6, 2018: JMIR Research Protocols
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