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Dietary nitrate

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https://www.readbyqxmd.com/read/28805918/effects-of-encapsulated-nitrate-on-growth-performance-carcass-characteristics-nitrate-residues-in-tissues-and-enteric-methane-emissions-in-beef-steers-finishing-phase
#1
C Lee, R C Araujo, K M Koenig, K A Beauchemin
A finishing feedlot study was conducted with beef steers to determine effects of encapsulated nitrate (EN) on growth performance, carcass characteristics, methane production, and nitrate (NO) residues in tissues. The 132 crossbred steers were backgrounded in a feedlot for 91 d and transitioned for 28 days to the high-concentrate diets evaluated in the present study, maintaining the treatment and pen assignments designated at the start of the backgrounding period. The steers were initially assigned to 22 pens (6 animals per pen) in a randomized complete block design with BW (18 pens) and animals designated for methane measurement (4 pens) as blocking factors...
August 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28805908/effects-of-encapsulated-nitrate-on-growth-performance-nitrate-toxicity-and-enteric-methane-emissions-in-beef-steers-backgrounding-phase
#2
C Lee, R C Araujo, K M Koenig, K A Beauchemin
A long-term experiment was conducted to examine the effects of feeding encapsulated nitrate (EN) on growth, enteric methane production, and nitrate (NO) toxicity in beef cattle fed a backgrounding diet. A total of 108 crossbred steers (292 ± 18 kg) were blocked by BW and randomly assigned to 18 pens. The pens (experimental unit; 6 animals per pen) received 3 dietary treatments: Control, a backgrounding diet supplemented with urea; 1.25% EN, control diet supplemented with 1.25% encapsulated calcium ammonium NO (i...
August 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28802834/vegetable-derived-bioactive-nitrate-and-cardiovascular-health
#3
REVIEW
Catherine P Bondonno, Lauren C Blekkenhorst, Alex H Liu, Nicola P Bondonno, Natalie C Ward, Kevin D Croft, Jonathan M Hodgson
Vegetable derived nitrate is now recognised as an important bioactive phytochemical with cardioprotective properties. Nitrate, through the recently described enterosalivary nitrate-nitrite-nitric oxide (NO) pathway, increases NO, a molecule pivotal for cardiovascular health. Clinical trials have observed that dietary nitrate has similar effects to NO when supplied exogenously. These effects include reduced blood pressure and improvements in other markers of vascular health such as endothelial function, arterial stiffness, ischemia reperfusion injury, blood flow, and platelet aggregation...
August 9, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28789663/inorganic-nitrate-as-a-treatment-for-acute-heart-failure-a-protocol-for-a-single-center-randomized-double-blind-placebo-controlled-pilot-and-feasibility-study
#4
Roman Falls, Michael Seman, Sabine Braat, Joshua Sortino, Jason D Allen, Christopher J Neil
BACKGROUND: Acute heart failure (AHF) is a frequent reason for hospitalization worldwide and effective treatment options are limited. It is known that AHF is a condition characterized by impaired vasorelaxation, together with reduced nitric oxide (NO) bioavailability, an endogenous vasodilatory compound. Supplementation of inorganic sodium nitrate (NaNO3) is an indirect dietary source of NO, through bioconversion. It is proposed that oral sodium nitrate will favorably affect levels of circulating NO precursors (nitrate and nitrite) in AHF patients, resulting in reduced systemic vascular resistance, without significant hypotension...
August 8, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28783446/dietary-nitrate-supplementation-does-not-improve-cycling-time-trial-performance-in-the-heat
#5
Georgina L Kent, Brian Dawson, Gregory R Cox, Louise M Burke, Annette Eastwood, Kevin D Croft, Peter Peeling
This investigation examined the effect of beetroot juice (BR) supplementation, a source of dietary nitrate (NO3(-)), on cycling time-trial (TT) performance and thermoregulation in the heat. In a double-blind, repeated-measures design, 12 male cyclists (age 26.6 ± 4.4 years, VO2peak 65.8 ± 5.5 mL.kg(-1).min(-1)) completed four cycling TTs (14 kJ.kg(-1)) in hot (35°C, 48% relative humidity) and euthermic (21°C, 52%) conditions, following 3 days supplementation with BR (6.5 mmol NO3(-) for 2 days and 13 mmol NO3(-) on the final day), or NO3(-)depleted placebo (PLA)...
August 7, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28743821/the-effect-of-dietary-nitrate-supplementation-on-the-spatial-heterogeneity-of-quadriceps-deoxygenation-during-heavy-intensity-cycling
#6
Brynmor C Breese, David C Poole, Dai Okushima, Stephen J Bailey, Andrew M Jones, Narihiko Kondo, Tatsuro Amano, Shunsaku Koga
This study investigated the influence of dietary inorganic nitrate (NO3(-)) supplementation on pulmonary O2 uptake (V˙O2) and muscle deoxyhemoglobin/myoglobin (i.e. deoxy [Hb + Mb]) kinetics during submaximal cycling exercise. In a randomized, placebo-controlled, cross-over study, eight healthy and physically active male subjects completed two step cycle tests at a work rate equivalent to 50% of the difference between the gas exchange threshold and peak V˙O2 over separate 4-day supplementation periods with NO3(-)-rich (BR; providing 8...
July 2017: Physiological Reports
https://www.readbyqxmd.com/read/28739973/conjugated-linoleic-acid-modulates-clinical-responses-to-oral-nitrite-and-nitrate
#7
Kara S Hughan, Stacy Gelhaus Wendell, Meghan Delmastro-Greenwood, Nicole Helbling, Catherine Corey, Landon Bellavia, Gopal Potti, George Grimes, Bret Goodpaster, Daniel B Kim-Shapiro, Sruti Shiva, Bruce A Freeman, Mark T Gladwin
Dietary NO3(-) (nitrate) and NO2(-) (nitrite) support (·)NO (nitric oxide) generation and downstream vascular signaling responses. These nitrogen oxides also generate secondary nitrosating and nitrating species that react with low molecular weight thiols, heme centers, proteins, and unsaturated fatty acids. To explore the kinetics of NO3(-)and NO2(-)metabolism and the impact of dietary lipid on nitrogen oxide metabolism and cardiovascular responses, the stable isotopes Na(15)NO3 and Na(15)NO2 were orally administered in the presence or absence of conjugated linoleic acid (cLA)...
July 24, 2017: Hypertension
https://www.readbyqxmd.com/read/28708316/dietary-plant-sterols-supplementation-increases-in-vivo-nitrite-and-nitrate-production-in-healthy-adults-a-randomized-controlled-study
#8
Xing Lin Ho, Wai Mun Loke
A randomized, double-blinded, placebo-controlled and crossover study was conducted to simultaneously measure the effects, 3 h after consumption and after 4-wk daily exposure to plant sterols-enriched food product, on in vivo nitrite and nitrate production in healthy adults. Eighteen healthy participants (67% female, 35.3 [mean] ± 9.5 [SD] years, mean body mass index 22.8 kg/m(2) ) received 2 soy milk (20 g) treatments daily: placebo and one containing 2.0 g free plant sterols equivalent of their palmityl esters (β-sitosterol, 55%; campesterol, 29%; and stigmasterol, 23%)...
July 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28701247/the-effect-of-dietary-addition-of-nitrate-or-increase-in-lipid-concentrations-alone-or-in-combination-on-performance-and-methane-emissions-of-beef-cattle
#9
C-A Duthie, S M Troy, J J Hyslop, D W Ross, R Roehe, J A Rooke
Adding nitrate to or increasing the concentration of lipid in the diet are established strategies for reducing enteric methane (CH4) emissions, but their effectiveness when used in combination has been largely unexplored. This study investigated the effect of dietary nitrate and increased lipid included alone or together on CH4 emissions and performance traits of finishing beef cattle. The experiment was a 2×4 factorial design comprising two breeds (cross-bred Aberdeen Angus (AAx) and cross-bred Limousin (LIMx) steers) and four dietary treatments (each based on 550 g forage : 450 g concentrate/kg dry matter (DM))...
July 13, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28684588/dietary-nitrate-supplementation-increases-acute-mountain-sickness-severity-and-sense-of-effort-during-hypoxic-exercise
#10
Gabriella M K Rossetti, Jamie Hugo Macdonald, Lee J Wylie, Samuel J Little, Victoria Newton, Benjamin Wood, Kieran A Hawkins, Rhys Beddoe, Hannah E Davies, Samuel James Oliver
Dietary nitrate supplementation enhances sea level performance and may ameliorate hypoxemia at high altitude. However, nitrate may exacerbate acute mountain sickness (AMS), specifically headache. This study investigated the effect of nitrate supplementation on AMS symptoms and exercise responses with 6h hypoxia. Twenty recreationally-active men (mean(SD): age 22(4) years, V̇O2max 51(6) mL·min-1·kg-1) completed this randomized double-blinded placebo-controlled crossover study. Twelve participants were classified as AMS- based on Environmental Symptom Questionnaire (AMS-C) score <0...
July 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28670117/dietary-beetroot-juice-effects-on-physical-performance-in-copd-patients-a-randomized-controlled-crossover-trial
#11
Anne Louise Friis, Carina Bjørnskov Steenholt, Anders Løkke, Mette Hansen
BACKGROUND AND OBJECTIVE: Dietary beetroot juice (BR) supplementation has been shown to reduce the oxygen (O2) consumption of standardized exercise and reduce resting blood pressure (BP) in healthy individuals. However, the physiological response of BR in chronic obstructive pulmonary disease (COPD) remains controversial. The objective was to test exercise performance in COPD, supplementing with higher doses of BR for a longer duration compared to previous trials in this patient group...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28663382/sodium-nitrate-ingestion-increases-skeletal-muscle-nitrate-content-in-humans
#12
Jean Nyakayiru, Imre W K Kouw, Naomi M Cermak, Joan M Senden, Luc J C van Loon, Lex B Verdijk
Nitrate (NO3(-)) ingestion has been shown to have vasoactive and ergogenic effects that have been attributed to increased nitric oxide (NO) production. Recent observations in rodents suggest skeletal muscle tissue to serve as an endogenous NO3(-) "reservoir". The current study determined NO3(-) contents in human skeletal muscle tissue in a post-absorptive state, and following ingestion of a sodium nitrate bolus (NaNO3). Seventeen male, type 2 diabetes patients (age 72±1 y; BMI 26.5±0.5 m·kg(-2)) were randomized to ingest a dose of NaNO3 (NIT; 9...
June 29, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28649367/nitric-oxide-signalling-and-neuronal-nitric-oxide-synthase-in-the-heart-under-stress
#13
REVIEW
Yin Hua Zhang
Nitric oxide (NO) is an imperative regulator of the cardiovascular system and is a critical mechanism in preventing the pathogenesis and progression of the diseased heart. The scenario of bioavailable NO in the myocardium is complex: 1) NO is derived from both endogenous NO synthases (endothelial, neuronal, and/or inducible NOSs [eNOS, nNOS, and/or iNOS]) and exogenous sources (entero-salivary NO pathway) and the amount of NO from exogenous sources varies significantly; 2) NOSs are located at discrete compartments of cardiac myocytes and are regulated by distinctive mechanisms under stress; 3) NO regulates diverse target proteins through different modes of post-transcriptional modification (soluble guanylate cyclase [sGC]/cyclic guanosine monophosphate [cGMP]/protein kinase G [PKG]-dependent phosphorylation, S-nitrosylation, and transnitrosylation); 4) the downstream effectors of NO are multidimensional and vary from ion channels in the plasma membrane to signalling proteins and enzymes in the mitochondria, cytosol, nucleus, and myofilament; 5) NOS produces several radicals in addition to NO (e...
2017: F1000Research
https://www.readbyqxmd.com/read/28649204/effects-of-dietary-nitrate-supplementation-on-physiological-responses-cognitive-function-and-exercise-performance-at-moderate-and-very-high-simulated-altitude
#14
Oliver M Shannon, Lauren Duckworth, Matthew J Barlow, Kevin Deighton, Jamie Matu, Emily L Williams, David Woods, Long Xie, Blossom C M Stephan, Mario Siervo, John P O'Hara
Purpose: Nitric oxide (NO) bioavailability is reduced during acute altitude exposure, contributing toward the decline in physiological and cognitive function in this environment. This study evaluated the effects of nitrate ([Formula: see text]) supplementation on NO bioavailability, physiological and cognitive function, and exercise performance at moderate and very-high simulated altitude. Methods:Ten males (mean (SD): [Formula: see text]: 60.9 (10.1) ml·kg(-1)·min(-1)) rested and performed exercise twice at moderate (~14...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28623824/dietary-nitrate-attenuates-renal-ischemia-reperfusion-injuries-by-modulation-of-immune-responses-and-reduction-of-oxidative-stress
#15
Ting Yang, Xing-Mei Zhang, Laura Tarnawski, Maria Peleli, Zhengbing Zhuge, Niccolo Terrando, Robert A Harris, Peder S Olofsson, Erik Larsson, A Erik G Persson, Jon O Lundberg, Eddie Weitzberg, Mattias Carlstrom
Ischemia-reperfusion (IR) injury involves complex pathological processes in which reduction of nitric oxide (NO) bioavailability is suggested as a key factor. Inorganic nitrate can form NO in vivo via NO synthase-independent pathways and may thus provide beneficial effects during IR. Herein we evaluated the effects of dietary nitrate supplementation in a renal IR model. Male mice (C57BL/6J) were fed nitrate-supplemented chow (1.0mmol/kg/day) or standard chow for two weeks prior to 30min ischemia and during the reperfusion period...
June 9, 2017: Redox Biology
https://www.readbyqxmd.com/read/28610958/sulfate-nitrate-and-blood-pressure-an-epic-interaction-between-sulfur-and-nitrogen
#16
REVIEW
Gunter G Kuhnle, Robert Luben, Kay-Tee Khaw, Martin Feelisch
Nitrate (NO3(-))-rich foods such as green leafy vegetables are not only part of a healthy diet, but increasingly marketed for primary prevention of cardiovascular disease (CVD) and used as ergogenic aids by competitive athletes. While there is abundant evidence for mild hypotensive effects of nitrate on acute application there is limited data on chronic intake in humans, and results from animal studies suggest no long-term benefit. This is important as nitrate can also promote the formation of nitrosamines...
August 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28603910/production-of-n2-and-n2-o-from-nitrate-ingested-by-sheep
#17
V de Raphélis-Soissan, J V Nolan, I R Godwin, J R Newbold, B D Eyre, D V Erler, R S Hegarty
Supplementing ruminants with nitrate (NO3-) reduces their enteric methane (CH4 ) emissions; however, the greenhouse gas (GHG) mitigation achieved can be partially offset by small emissions of nitrous oxide (N2 O), a more potent GHG. Sheep were dosed intraruminally with (15) NO3- to investigate whether dietary NO3- is a precursor of N2 O and/or di-nitrogen gas (N2 ), and to quantify the amounts of NO3- recovered as N2 O and N2 in gas emissions from sheep adapted or not adapted to dietary NO3-. Ruminally cannulated sheep were adapted to a hay diet supplemented with NO3- (n = 3; 10 g NO3-/kg DM) or urea (n = 3; 5...
June 12, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28596764/the-structural-and-functional-capacity-of-ruminal-and-cecal-microbiota-in-growing-cattle-was-unaffected-by-dietary-supplementation-of-linseed-oil-and-nitrate
#18
Milka Popova, Emily McGovern, Matthew S McCabe, Cécile Martin, Michel Doreau, Marie Arbre, Sarah J Meale, Diego P Morgavi, Sinéad M Waters
Microorganisms in the digestive tract of ruminants differ in their functionality and ability to use feed constituents. While cecal microbiota play an important role in post-rumen fermentation of residual substrates undigested in the rumen, limited knowledge exists regarding its structure and function. In this trial we investigated the effect of dietary supplementation with linseed oil and nitrate on methane emissions and on the structure of ruminal and cecal microbiota of growing bulls. Animals were allocated to either a CTL (control) or LINNIT (CTL supplemented with 1...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28596448/association-of-vegetable-nitrate-intake-with-carotid-atherosclerosis-and-ischemic-cerebrovascular-disease-in-older-women
#19
Catherine P Bondonno, Lauren C Blekkenhorst, Richard L Prince, Kerry L Ivey, Joshua R Lewis, Amanda Devine, Richard J Woodman, Jon O Lundberg, Kevin D Croft, Peter L Thompson, Jonathan M Hodgson
BACKGROUND AND PURPOSE: A short-term increase in dietary nitrate (NO3(-)) improves markers of vascular health via formation of nitric oxide and other bioactive nitrogen oxides. Whether this translates into long-term vascular disease risk reduction has yet to be examined. We investigated the association of vegetable-derived nitrate intake with common carotid artery intima-media thickness (CCA-IMT), plaque severity, and ischemic cerebrovascular disease events in elderly women (n=1226). METHODS: Vegetable nitrate intake, lifestyle factors, and cardiovascular disease risk factors were determined at baseline (1998)...
June 8, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28596274/dietary-nitrate-restores-compensatory-vasodilation-and-exercise-capacity-in-response-to-a-compromise-in-oxygen-delivery-in-the-non-compensator-phenotype
#20
Robert F Bentley, Jeremy J Walsh, Patrick J Drouin, Aleksandra Velickovic, Sarah J Kitner, Alyssa M Fenuta, Michael E Tschakovsky
Recently dietary nitrate supplementation has been shown to improve exercise capacity in healthy individuals through a potential nitrate-nitrite-nitric oxide pathway. Nitric oxide has been shown to play an important role in compensatory vasodilation during exercise under hypoperfusion. Previously we established that certain individuals lack a vasodilation response when perfusion pressure reductions compromise exercising muscle blood flow. Whether this lack of compensatory vasodilation in healthy young individuals can be restored with dietary nitrate supplementation is unknown...
June 8, 2017: Journal of Applied Physiology
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