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Dietary nitrate

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https://www.readbyqxmd.com/read/29211505/the-effect-of-dietary-nitrate-on-nocturnal-sleep-disordered-breathing-and-arterial-oxygen-desaturation-at-high-altitude
#1
Alexander Patrician, Harald Engan, David Lundsten, Ludger Grote, Helena Vigetun-Haughey, Erika Schagatay
Patrician, Alexander, Harald Engan, David Lundsten, Ludger Grote, Helena Vigetun-Haughey, and Erika Schagatay. The effect of dietary nitrate on nocturnal sleep-disordered breathing and arterial oxygen desaturation at high altitude. High Alt Med Biol 00:000-000, 2017.-Sleep-disordered breathing and fluctuations in arterial oxygen saturation (SaO2) are common during sleep among lowlanders ascending to high altitude. Dietary nitrate (NO3-) supplementation has been shown to lower the O2 consumption in various conditions...
December 6, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29190751/acute-effect-of-dietary-nitrate-on-forearm-muscle-oxygenation-blood-volume-and-strength-in-older-adults-a-randomized-clinical-trial
#2
Gustavo Vieira de Oliveira, Marina Morgado, Carlos Adam Conte-Junior, Thiago Silveira Alvares
Both recovery time of post-exercise muscle oxygenation and muscle strength decline with aging. Although beetroot consumption has been shown to improve muscle oxygenation and exercise performance in adults, these effects in the elderly has not been addressed. The aim of the present study was to evaluate the effect of a beetroot-based gel (BG) on muscle O2 saturation, blood volume (tHb) and handgrip strength in the elderly in response to handgrip exercise. In a randomized crossover double-blind design, twelve older subjects consumed BG (100 g of beetroot-based gel containing ~ 12 mmol nitrate) or PLA (100 g of nitrate-depleted gel nitrate-depleted)...
2017: PloS One
https://www.readbyqxmd.com/read/29165355/acute-effects-of-nitrate-rich-beetroot-juice-on-blood-pressure-hemostasis-and-vascular-inflammation-markers-in-healthy-older-adults-a-randomized-placebo-controlled-crossover-study
#3
Kyle Raubenheimer, Danica Hickey, Michael Leveritt, Robert Fassett, Joaquin Ortiz de Zevallos Munoz, Jason D Allen, David Briskey, Tony J Parker, Graham Kerr, Jonathan M Peake, Natalie M Pecheniuk, Oliver Neubauer
Aging is associated with a vasoconstrictive, pro-coagulant, and pro-inflammatory profile of arteries and a decline in the bioavailability of the endothelium-derived molecule nitric oxide. Dietary nitrate elicits vasodilatory, anti-coagulant and anti-inflammatory effects in younger individuals, but little is known about whether these benefits are evident in older adults. We investigated the effects of 140 mL of nitrate-rich (HI-NI; containing 12.9 mmol nitrate) versus nitrate-depleted beetroot juice (LO-NI; containing ≤0...
November 22, 2017: Nutrients
https://www.readbyqxmd.com/read/29151027/plasma-nitrate-and-incidence-of-cardiovascular-disease-and-all-cause-mortality-in-the-community-the-framingham-offspring-study
#4
Renke Maas, Vanessa Xanthakis, Thomas Göen, Johannes Müller, Edzard Schwedhelm, Rainer H Böger, Ramachandran Vasan
BACKGROUND: Nitrate is a dietary component as well as an endogenously formed metabolite and source of the signaling molecule nitric oxide. Harmful as well as beneficial effects of nitrate have been advocated. Data regarding the prognostic relevance of plasma nitrate are limited. The aim of this study was to evaluate the prospective association of plasma nitrate with cardiovascular disease (CVD) and all-cause mortality. METHODS AND RESULTS: We assayed plasma nitrate in 2855 Framingham Offspring Study participants (mean age 59 years, 54% women) by gas chromatography-mass spectrometry and evaluated its association with all-cause mortality and incident CVD...
November 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29134675/analytical-approach-dissipation-pattern-and-risk-assessment-of-pesticide-residue-in-green-leafy-vegetables-a-comprehensive-review
#5
REVIEW
Waziha Farha, A M Abd El-Aty, Md Musfiqur Rahman, Ji Hoon Jeong, Ho-Chul Shin, Jing Wang, Sung Shik Shin, Jae-Han Shim
The category of "leafy vegetables" comprises a wide range of plants, including cabbage, lettuce, leeks, spinach, Swiss chard, and kale, and it forms a significant component of the human diet. Typically, leafy vegetables are low in calories and fat, are great sources of vitamins, protein, dietary fibre, minerals (including iron, calcium, and nitrates), and are rich in phytochemicals. To counter the impact of pests on vegetables, a broad variety of pesticides is used. Because of their large surface areas, leafy vegetables are expected to have high residual pesticide levels...
November 14, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29116537/critical-analysis-of-excessive-utilization-of-crude-protein-in-ruminants-ration-impact-on-environmental-ecosystem-and-opportunities-of-supplementation-of-limiting-amino-acids-a-review
#6
Imtiaz Hussain Raja Abbasi, Farzana Abbasi, Mohamed E Abd El-Hack, Mervat A Abdel-Latif, Rab N Soomro, Khawar Hayat, Mohamed A E Mohamed, Bello M Bodinga, Junhu Yao, Yangchun Cao
Protein quality plays a key role than quantity in growth, production, and reproduction of ruminants. Application of high concentration of dietary crude protein (CP) did not balance the proportion of these limiting amino acids (AA) at duodenal digesta of high producing dairy cow. Thus, dietary supplementation of rumen-protected AA is recommended to sustain the physiological, productive, and reproductive performance of ruminants. Poor metabolism of high CP diets in rumen excretes excessive nitrogen (N) through urine and feces in the environment...
November 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29108664/the-effect-of-acute-and-7-days-dietary-nitrate-on-mechanical-efficiency-exercise-performance-and-cardiac-biomarkers-in-patients-with-chronic-obstructive-pulmonary-disease
#7
Rosanne J H C G Beijers, Stephanie M D Huysmans, Coby van de Bool, Boris R M Kingma, Lex B Verdijk, Luc J C van Loon, Steven J R Meex, Harry R Gosker, Annemie M W J Schols
BACKGROUND & AIMS: Many COPD patients have a reduced exercise capacity and mechanical efficiency and are at increased cardiometabolic risk. This study aimed to assess acute and 7-days effects of dietary nitrate on mechanical efficiency, exercise performance and cardiac biomarkers in patients with COPD. METHODS: This double-blind, randomized cross-over placebo controlled trial included 20 mild-to-moderate COPD patients (66.6 ± 7.5 years) with moderate exercise impairments and decreased mechanical efficiency, normal BMI (26 ± 3 kg/m(2)) but high prevalence of abdominal obesity (83...
October 31, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29101174/dietary-nitrate-supplementation-in-cardiovascular-health-an-ergogenic-aid-or-exercise-therapeutic
#8
Mary N Woessner, Luke Colin McIlvenna, Joaquin Ortiz de Zevallos, Christopher Neil, Jason David Allen
Oral consumption of inorganic nitrate, which is abundant in green leafy vegetables and roots, has been shown to increase circulating plasma nitrite concentration, which can be converted to NO in low oxygen conditions. The associated beneficial physiological effects include a reduction in blood pressure, modification of platelet aggregation and increases in limb blood flow. There have been numerous studies of nitrate supplementation in healthy recreational and competitive athletes, however, the ergogenic benefits are currently unclear due to a variety of factors including small sample sizes, different dosing regimens, variable nitrate conversion rates, the heterogeneity of participants' initial fitness levels and the types of exercise tests employed...
November 3, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29095117/exposure-estimates-of-nitrite-and-nitrate-from-consumption-of-cured-meat-products-by-the-u-s-population
#9
Hyoung S Lee
The dietary exposures of nitrite and nitrate from consumption of cured meat products were estimated for the U.S. population aged 2 years and older, and children aged 2 to 5 years, using both 2-day food consumption data from the publicly available combined 2009-2012 National Health and Nutrition Examination Survey (NHANES) and 10-14-day food consumption data from the 2009-2012 NPD Group, Inc. National Eating Trends-Nutrient Intake database (NPD NET-NID), and residual nitrite and nitrate levels in cured meat products available from the recent American Meat Institute Foundation/National Pork Board (AMIF/NPB) national market survey of the nitrite and nitrate levels in cured meat products in the U...
November 2, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29094243/alleviation-of-cardiac-damage-by-dietary-fenugreek-trigonella-foenum-graecum-seeds-is-potentiated-by-onion-allium-cepa-in-experimental-diabetic-rats-via-blocking-renin-angiotensin-system
#10
Seetur R Pradeep, Krishnapura Srinivasan
Hyperglycemia is one of the metabolic and homeostatic abnormalities that increase the cardiovascular mortality in diabetic patients by increased oxidative stress. We have recently reported amelioration of oxidative stress in cardiac tissue by dietary fenugreek (Trigonella foenum-graecum) seeds and onion (Allium cepa) in streptozotocin-induced diabetic rats. The mechanistic aspects of the cardio-protective influence of dietary fenugreek seeds (10%) and onion (3% powder) both individually and in combination on hyperglycemia-mediated cardiac damage was further investigated in this study on streptozotocin-induced diabetic rats...
November 1, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29093281/the-effects-of-essential-oil-povidone-iodine-and-chlorhexidine-mouthwash-on-salivary-nitrate-nitrite-and-nitrate-reducing-bacteria
#11
Takahiro Mitsui, Ryô Harasawa
Dietary nitrate is reduced to nitrite and nitric oxide by microbial flora, and this activity is beneficial to vascular health. It has been reported that this bacterial process is inhibited by chlorhexidine mouthwash, although the effects of other products are largely unknown. This study examined the effects of several treatments on salivary nitrate/nitrite and nitrate-reducing bacteria. Twelve university staff and students performed mouth-washing with water (control), essential oil, 0.35% povidone-iodine, or 0...
October 31, 2017: Journal of Oral Science
https://www.readbyqxmd.com/read/29091471/the-effect-of-a-dietary-nitrate-supplementation-in-the-form-of-a-single-shot-of-beetroot-juice-on-static-and-dynamic-apnoea-performance
#12
Matthew J Barlow, Antonis Elia, Oliver M Shannon, Angeliki Zacharogianni, Angelica Lodin-Sundstrom
INTRODUCTION: The purpose of the present study was to assess the effects of acute nitrate (NO3(-))-rich beetroot juice supplementation on peripheral oxygen saturation (SpO2), heart rate (HR), and pulmonary gas exchange during submaximal static and dynamic apnoea. METHODS: Nine (six male, three female) trained apneists (age: 39.6 ± 8.2 years, stature: 170.4 ± 11.5cm, body mass: 72.0 ± 11.5 kg) performed three submaximal static apnoeas at 60%, 70% and 80% of the participant's current reported personal best time, followed by three submaximal (~ 75% or personal best distance) dynamic apnoeas following the consumption of either a 140 ml concentrated NO3(-)-rich beetroot juice (BRJ; 7...
November 1, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29082595/cutaneous-reactive-hyperaemia-is-unaltered-by-dietary-nitrate-supplementation-in-healthy-humans
#13
Brett J Wong, Jeremy T Keen, Erica L Levitt
The purpose of this study was to determine whether nitrate supplementation augments cutaneous reactive hyperaemia. Seven participants were tested pre- and postnitrate supplementation (25 ml beetroot juice); participants consumed one shot per day for 3 days. Participants were instrumented with two microdialysis fibres: control (Ringer's solution) and NO synthase inhibition (20 mM L-NAME). Skin blood flow was measured via laser-Doppler flowmetry (LDF). A blood pressure cuff was placed on the experimental arm and inflated to 250 mmHg for 5 mins to occlude arterial inflow...
October 29, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29077028/performance-and-health-benefits-of-dietary-nitrate-supplementation-in-older-adults-a-systematic-review
#14
REVIEW
Luke Stanaway, Kay Rutherfurd-Markwick, Rachel Page, Ajmol Ali
Supplementation with nitrate (NO₃(-))-rich beetroot juice has been shown to improve exercise performance and cardiovascular (CV) responses, due to an increased nitric oxide (NO) availability. However, it is unclear whether these benefits are greater in older adults who have an age-related decrease in NO and higher risk of disease. This systematic review examines 12 randomised, crossover, control trials, investigating food-based NO₃(-) supplementation in older adults and its potential benefits on physiological and cognitive performances, and CV, cerebrovascular and metabolic health...
October 27, 2017: Nutrients
https://www.readbyqxmd.com/read/29066597/muscle-oxygenation-profiles-between-active-and-inactive-muscles-with-nitrate-supplementation-under-hypoxic-exercise
#15
Masahiro Horiuchi, Junko Endo, Shohei Dobashi, Yoko Handa, Masataka Kiuchi, Katsuhiro Koyama
Whether dietary nitrate supplementation improves exercise performance or not is still controversial. While redistribution of sufficient oxygen from inactive to active muscles is essential for optimal exercise performance, no study investigated the effects of nitrate supplementation on muscle oxygenation profiles between active and inactive muscles. Nine healthy males performed 25 min of submaximal (heart rate ~140 bpm; EXsub) and incremental cycling (EXmax) until exhaustion under three conditions: (A) normoxia without drink; (B) hypoxia (FiO2 = 13...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29042272/effects-of-dietary-nitrate-on-respiratory-physiology-at-high-altitude-results-from-the-xtreme-alps-study
#16
Andrew F Cumpstey, Philip J Hennis, Edward T Gilbert-Kawai, Bernadette O Fernandez, Matthieu Poudevigne, Alexandra Cobb, Paula Meale, Kay Mitchell, Helen Moyses, Helmut Pöhnl, Monty G Mythen, Michael P W Grocott, Martin Feelisch, Daniel S Martin
Nitric oxide (NO) production plays a central role in conferring tolerance to hypoxia. Tibetan highlanders, successful high-altitude dwellers for millennia, have higher circulating nitrate and exhaled NO (ENO) levels than native lowlanders. Since nitrate itself can reduce the oxygen cost of exercise in normoxia it may confer additional benefits at high altitude. Xtreme Alps was a double-blinded randomised placebo-controlled trial to investigate how dietary nitrate supplementation affects physiological responses to hypoxia in 28 healthy adult volunteers resident at 4559 m for 1 week; 14 receiving a beetroot-based high-nitrate supplement and 14 receiving a low-nitrate 'placebo' of matching appearance/taste...
December 1, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29037770/dietary-nitrate-supplementation-opposes-the-elevated-diaphragm-blood-flow-in-chronic-heart-failure-during-submaximal-exercise
#17
Joshua R Smith, Scott K Ferguson, K Sue Hageman, Craig A Harms, David C Poole, Timothy I Musch
Chronic heart failure (CHF) results in a greater cost of breathing and necessitates an elevated diaphragm blood flow (BF). Dietary nitrate (NO3‾) supplementation lowers the cost of exercise. We hypothesized that dietary NO3‾ supplementation would attenuate the CHF-induced greater cost of breathing and thus the heightened diaphragm BF during exercise. CHF rats received either 5days of NO3‾-rich beetroot (BR) juice (CHF+BR, n=10) or a placebo (CHF, n=10). Respiratory muscle BFs (radiolabeled microspheres) were measured at rest and during submaximal exercise (20m/min, 5% grade)...
October 14, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29035954/effectiveness-of-dietary-inorganic-nitrate-in-lowering-blood-pressure-in-hypertensive-adults-a-systematic-review-protocol
#18
Jennifer Remington, Karen Winters
The question of this review is: what is the effect of dietary inorganic nitrate on blood pressure in adults with blood pressure >120/80mmHg?
October 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28974486/combined-dietary-nitrate-and-exercise-intervention-in-peripheral-artery-disease-protocol-rationale-and-design
#19
Mary N Woessner, Mitch D VanBruggen, Carl F Pieper, Erin K O'Reilly, William E Kraus, Jason D Allen
BACKGROUND: Peripheral artery disease (PAD) is caused by atherosclerotic occlusions in the legs. It affects approximately 8-12 million people in the United States alone, one-third of whom suffer from intermittent claudication (IC), defined as ischemic leg pain that occurs with walking and improves with rest. Patients with IC suffer a markedly impaired quality of life and a high perception of disability. Improving pain-free walking time is a primary goal of rehabilitation in this population...
October 3, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28960068/mineral-dietary-supplement-to-decrease-cadmium-relative-bioavailability-in-rice-based-on-a-mouse-bioassay
#20
Di Zhao, Albert L Juhasz, Jun Luo, Lei Huang, Xiao-San Luo, Hong-Bo Li, Lena Q Ma
To determine the effectiveness of mineral dietary supplements to modulate cadmium (Cd) exposure, an in vivo mouse bioassay was conducted to determine Cd relative bioavailability (Cd-RBA) in Cd-contaminated rice (0.80 mg Cd kg(-1)) with and without Zn, Fe, or Ca supplements as nitrate or chloride salts. Without mineral supplements, Cd-RBA was 43 ± 5.3% based on average Cd accumulation in the liver plus kidneys as the end point. Among Ca(NO3)2, Zn(NO3)2, and Fe(NO3)2 supplements, 150-5000 mg kg(-1) Ca was the most effective in reducing rice Cd-RBA by 31-80% to 8...
November 7, 2017: Environmental Science & Technology
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