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Dietary nitrate

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https://www.readbyqxmd.com/read/28215082/development-of-a-quechers-based-method-for-the-determination-of-carcinogenic-2-nitrofluorene-and-1-nitropyrene-in-rice-grains-and-vegetables-a-comparative-study-with-benzo-a-pyrene
#1
Kailin Deng, Wan Chan
Nitrated polycyclic aromatic hydrocarbons (nitro-PAHs) are ubiquitous environmental pollutants attracting increasing attention because of their potent mutagenicity to humans. Previous studies of nitro-PAHs focused on investigating their formation mechanisms and detecting them in atmospheric environment, however, few studies reported their occurrence in food samples and regulations on nitro-PAHs are still lacking. We report in this study the development and application of a Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) method for the determination of nitro-PAHs in rice and vegetable samples...
February 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28203456/concurrent-beet-juice-and-carbohydrate-ingestion-influence-on-glucose-tolerance-in-obese-and-nonobese-adults
#2
Joseph W Beals, Scott E Binns, Janelle L Davis, Gregory R Giordano, Anna L Klochak, Hunter L Paris, Melani M Schweder, Garrett L Peltonen, Rebecca L Scalzo, Christopher Bell
Insulin resistance and obesity are characterized by low nitric oxide (NO) bioavailability. Insulin sensitivity is improved with stimulation of NO generating pathways. Consumption of dietary nitrate (NO3(-)) increases NO formation, via NO3(-) reduction to nitrite (NO2(-)) by oral bacteria. We hypothesized that acute dietary nitrate (beet juice) ingestion improves insulin sensitivity in obese but not in nonobese adults. 12 nonobese (body mass index: 26.3 ± 0.8 kg/m(2) (mean ± SE)) and 10 obese adults (34...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/28196859/dietary-nitrite-reverses-features-of-postmenopausal-metabolic-syndrome-induced-by-high-fat-diet-and-ovariectomy-in-mice
#3
Kazuo Ohtake, Nobuyuki Ehara, Hiroshige Chiba, Genya Nakano, Kunihiro Sonoda, Junta Ito, Hiroyuki Uchida, Jun Kobayashi
Menopausal women are at greater risk of developing metabolic syndrome with reduced endothelial nitric oxide synthase (eNOS) activity. Hormone replacement therapy increases eNOS activity and normalizes some characteristics of metabolic syndrome. We hypothesized that nitric oxide (NO) supplementation should have a therapeutic effect in this syndrome. We examined the effect of dietary nitrite on mice model with postmenopausal metabolic syndrome induced by ovariectomy (OVX) with high fat diet (HF). C57BL/6 female mice were divided into five groups, sham+normal fat diet (NF), sham+ HF, OVX+HF without or with sodium nitrite (50mg and 150mg/L) in drinking water...
February 14, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28182502/effect-of-dietary-nitrate-supplementation-on-swimming-performance-in-trained-swimmers
#4
Sam Lowings, Oliver Michael Shannon, Kevin Deighton, Jamie Matu, Matthew John Barlow
Nitrate supplementation appears to be most ergogenic when oxygen availability is restricted and subsequently may be particularly beneficial for swimming performance due to the breath-hold element of this sport. This represents the first investigation of nitrate supplementation and swimming time-trial (TT) performance. In a randomised double-blind repeated-measures crossover study, ten (5male, 5female) trained swimmers ingested 140ml nitrate-rich (~12.5mmol nitrate) or nitrate-depleted (~0.01mmol nitrate) beetroot juice...
February 9, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28179228/dietary-nitrate-does-not-reduce-oxygen-cost-of-exercise-or-improve-muscle-mitochondrial-function-in-mitochondrial-myopathy-patients
#5
Miranda Nabben, Joep P J Schmitz, Jolita Ciapaite, Carlijn M P Le Clercq, Natal A van Riel, Harm R Haak, Klaas Nicolay, Irenaeus F de Coo, Hubert J M Smeets, Stephan F Praet, Luc J C van Loon, Jeanine J Prompers
Muscle weakness and exercise intolerance negatively affect the quality of life of mitochondrial myopathy patients. Short-term dietary nitrate supplementation has been shown to improve exercise performance and reduce oxygen cost of exercise in healthy humans and trained athletes. We investigated if 1 week of dietary inorganic nitrate supplementation decreases the oxygen cost of exercise and improves mitochondrial function in mitochondrial myopathy patients. Ten mitochondrial myopathy patients (40 ± 5 years, maximal whole-body oxygen uptake = 21...
February 8, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28150478/effects-of-silk-peptides-administration-on-fat-utilization-over-a-whole-day-in-mice
#6
Jisu Kim, Jonghoon Park, Bokyung Kim, Chi-Ho Lee, Kiwon Lim
Purpose: The aim of the present narrative review was to consider the evidence on the timing, optimal dose and intake duration of the main dietary supplements β-alanine, nitrate, caffeine, creatine, sodium bicarbonate, carbohydrate and protein. Methods: This review article will focuses on timing, optimal dose and intake duration of main dietary supplements for consuming. Results: This paper reviewed the evidence to determine the optimal time, efficacy doses and intake duration for sports supplements verified by scientific evidence that report a performance enhancing effect in both situation of laboratory and training settings...
December 31, 2016: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28150472/timing-optimal-dose-and-intake-duration-of-dietary-supplements-with-evidence-based-use-in-sports-nutrition
#7
REVIEW
Alireza Naderi, Erick P de Oliveira, Tim N Ziegenfuss, Mark E T Willems
Purpose: The aim of the present narrative review was to consider the evidence on the timing, optimal dose and intake duration of the main dietary supplements β-alanine, nitrate, caffeine, creatine, sodium bicarbonate, carbohydrate and protein. Methods: This review article will focuses on timing, optimal dose and intake duration of main dietary supplements for consuming. Results: This paper reviewed the evidence to determine the optimal time, efficacy doses and intake duration for sports supplements verified by scientific evidence that report a performance enhancing effect in both situation of laboratory and training settings...
31, 2016: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28137609/dietary-nitrate-load-lowers-blood-pressure-and-renal-resistive-index-in-patients-with-chronic-kidney-disease-a-pilot-study
#8
Stephan Kemmner, Georg Lorenz, Jana Wobst, Thorsten Kessler, Ming Wen, Roman Günthner, Konrad Stock, Uwe Heemann, Klaus Burkhardt, Marcus Baumann, Christoph Schmaderer
Beetroot has a high concentration of inorganic nitrate, which can serially reduced to form nitrite and nitric oxide (NO) after oral ingestion. Increased renal resistive index (RRI) measured by Doppler ultrasonography is associated with higher cardiovascular mortality in hypertensive patients with reduced renal function over time defined as chronic kidney disease (CKD). Our aim was to investigate whether the supplementation of dietary nitrate by administration of beetroot juice is able to reduce blood pressure and renal resistive index (RRI) as prognostic markers for cardiovascular mortality in CKD patients...
January 28, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28120718/nutraceuticals-and-dietary-supplements-to-improve-quality-of-life-and-outcomes-in-heart-failure-patients
#9
Arrigo Fg Cicero, Alessandro Colletti
BACKGROUND: Heart failure (HF) is a complex clinical syndrome that can result from any structural or functional cardiac disorder that impairs the ability of the ventricle to fill or eject blood. It represents a major public health issue, with a prevalence of over 23 million worldwide. The lifetime risk of developing HF is one in five and the most important risk factors identified are ischemic heart disease, hypertension, smoking, obesity and diabetes. Preventive approaches are based on improvements of lifestyle, associated with pharmacological therapy...
January 24, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28107724/effect-of-sole-or-combined-administration-of-nitrate-and-3-nitro-1-propionic-acid-on-fermentation-and-salmonella-survivability-in-alfalfa-fed-rumen-cultures-in-vitro
#10
Alejandro Castañeda Correa, Julian Trachsel, Heather K Allen, Agustin Corral-Luna, Hector Gutierrez-Bañuelos, Pedro Antonia Ochoa-Garcia, Oscar Ruiz-Barrera, Michael E Hume, Todd R Callaway, Roger B Harvey, Ross C Beier, Robin C Anderson, David J Nisbet
Ruminal methanogenesis is a digestive inefficiency resulting in the loss of dietary energy consumed by the host and contributing to environmental methane emission. Nitrate is being investigated as a feed supplement to reduce rumen methane emissions but safety and efficacy concerns persist. To assess potential synergies of co-administering sub-toxic amounts of nitrate and 3-nitro-1-propionate (NPA) on fermentation and Salmonella survivability with an alfalfa-based diet, ruminal microbes were cultured with additions of 8 or 16mM nitrate, 4 or 12mM NPA or their combinations...
April 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28105786/development-of-a-reference-database-for-assessing-dietary-nitrate-in-vegetables
#11
Lauren C Blekkenhorst, Richard L Prince, Natalie C Ward, Kevin D Croft, Joshua R Lewis, Amanda Devine, Sujata Shinde, Richard J Woodman, Jonathan M Hodgson, Catherine P Bondonno
SCOPE: Nitrate from vegetables improves vascular health with short term intake. Whether this translates into improved long term health outcomes has yet to be investigated. To enable reliable analysis of nitrate intake from food records there is a strong need for a comprehensive nitrate content of vegetables database. METHODS AND RESULTS: A systematic literature search (1980-2016) was performed using Medline, Agricola and CAB abstracts databases. The nitrate content of vegetables database contains 4237 records from 255 publications with data on 178 vegetables and 22 herbs and spices...
January 19, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28100284/role-of-flavonoids-and-nitrates-in-cardiovascular-health
#12
Julie A Lovegrove, Alex Stainer, Ditte A Hobbs
CVD remain the leading cause of death globally. Effective dietary strategies for their reduction are of high priority. Increasing evidence suggests that phytochemicals, particularly dietary flavonoids and nitrates, are key modulators of CVD risk reduction through impact on multiple risk factors. The aim of this review is to explore the evidence for the impact of flavonoid- and nitrate-rich foods and supplements on CVD risk, with specific reference to their importance as mediators of vascular health and platelet function...
January 19, 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/28096758/effects-of-acute-ingestion-of-a-pre-workout-dietary-supplement-with-and-without-p-synephrine-on-resting-energy-expenditure-cognitive-function-and-exercise-performance
#13
Y Peter Jung, Conrad P Earnest, Majid Koozehchian, Elfego Galvan, Ryan Dalton, Dillon Walker, Christopher Rasmussen, Peter S Murano, Mike Greenwood, Richard B Kreider
BACKGROUND: The purpose of this study was to examine the effects of acute ingestion of a pre-workout dietary supplement (PWS) with and without p-synephrine (S) on perceptions of readiness to perform, cognitive function, exercise performance, and markers of safety. METHODS: In a randomized, double-blind, and counterbalanced manner; 25 healthy and recreationally active male and female participants ingested a flavored maltodextrin placebo (PLA), a PWS containing beta-alanine (3 g), creatine nitrate as a salt (2 g), arginine alpha-ketoglutarate (2 g), N-Acetyl-L-Tyrosine (300 mg), caffeine (284 mg), Mucuna pruiriens extract standardized for 15% L-Dopa (15 mg), Vitamin C as Ascorbic Acid (500 mg), niacin (60 mg), folate as folic acid (50 mg), and Vitamin B12 as Methylcobalamin (70 mg) with 2 g of maltodextrin and flavoring; or, the PWS with Citrus aurantium (PWS + S) extract standardized for 30% p-synephrine (20 mg)...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28096757/effects-of-ingesting-a-pre-workout-dietary-supplement-with-and-without-synephrine-for-8%C3%A2-weeks-on-training-adaptations-in-resistance-trained-males
#14
Y Peter Jung, Conrad P Earnest, Majid Koozehchian, Minye Cho, Nick Barringer, Dillon Walker, Christopher Rasmussen, Mike Greenwood, Peter S Murano, Richard B Kreider
BACKGROUND: The purpose of this study was to examine whether ingesting a pre-workout dietary supplement (PWS) with and without synephrine (S) during training affects training responses in resistance-trained males. METHODS: Resistance-trained males (N = 80) were randomly assigned to supplement their diet in a double-blind manner with either a flavored placebo (PLA); a PWS containing beta-alanine (3 g), creatine nitrate as a salt (2 g), arginine alpha-ketoglutarate (2 g), N-Acetyl-L-Tyrosine (300 mg), caffeine (284 mg), Mucuna pruiriens extract standardized for 15% L-Dopa (15 mg), Vitamin C as Ascorbic Acid (500 mg), niacin (60 mg), folate as folic acid (50 mg), and Vitamin B12 as Methylcobalamin (70 mg); or, the PWS supplement with Citrus aurantium extract containing 20 mg of synephrine (PWS + S) once per day for 8-weeks during training...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28090634/dietary-interventions-for-fetal-growth-restriction-therapeutic-potential-of-dietary-nitrate-supplementation-in-pregnancy
#15
Elizabeth Cottrell, Teresa Tropea, Laura Ormesher, Susan Greenwood, Mark Wareing, Edward Johnstone, Jenny Myers, Colin Sibley
Fetal growth restriction (FGR) affects around 5% of pregnancies and is associated with significant short- and long-term adverse outcomes. A number of factors can increase the risk of FGR, one of which is poor maternal diet. In terms of pathology, both clinically and in many experimental models of FGR, impaired uteroplacental vascular function is implicated, leading to a reduction in the delivery of oxygen and nutrients to the developing fetus. Whilst mechanisms underpinning impaired uteroplacental vascular function are not fully understood, interventions aimed at enhancing nitric oxide (NO) bioavailability remain a key area of interest in obstetric research...
January 16, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28087899/increasing-dietary-nitrate-has-no-effect-on-cancellous-bone-loss-or-fecal-microbiome-in-ovariectomized-rats
#16
Melissa N Conley, Cooper Roberts, Thomas J Sharpton, Urszula T Iwaniec, Norman Hord
Studies suggest diets rich in fruit and vegetables reduce bone loss, although the specific compounds responsible are unknown. Substrates for endogenous nitric oxide (NO) production, including organic nitrates and dietary nitrate, may support NO production in age-related conditions, including osteoporosis. We investigated the capability of dietary nitrate to improve NO bioavailability, reduce bone turnover and loss. Six-month-old Sprague Dawley rats [30 ovariectomized (OVX) and 10 sham-operated (sham)] were randomized into 3 groups: (1) vehicle (water) control, (2) low-dose nitrate (LDN, 0...
January 13, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28057862/antiinflammatory-actions-of-inorganic-nitrate-stabilize-the-atherosclerotic-plaque
#17
Rayomand S Khambata, Suborno M Ghosh, Krishnaraj S Rathod, Tharssana Thevathasan, Federica Filomena, Qingzhong Xiao, Amrita Ahluwalia
Reduced bioavailable nitric oxide (NO) plays a key role in the enhanced leukocyte recruitment reflective of systemic inflammation thought to precede and underlie atherosclerotic plaque formation and instability. Recent evidence demonstrates that inorganic nitrate (NO3(-)) through sequential chemical reduction in vivo provides a source of NO that exerts beneficial effects upon the cardiovascular system, including reductions in inflammatory responses. We tested whether the antiinflammatory effects of inorganic nitrate might prove useful in ameliorating atherosclerotic disease in Apolipoprotein (Apo)E knockout (KO) mice...
January 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28050806/nitrate-rich-beetroot-juice-selectively-lowers-ambulatory-pressures-and-ldl-cholesterol-in-uncontrolled-but-not-controlled-hypertension-a-pilot-study
#18
C P Kerley, E Dolan, L Cormican
BACKGROUND: Dietary nitrate has been shown to increase nitrate/nitrite levels in multiple populations, with potential blood pressure lowering effects. However, there are few reports among hypertensives. AIMS: We aimed to assess the effect of daily nitrate in subjects with controlled hypertension vs. uncontrolled hypertension. METHODS: On day 0, hypertensives wore an ambulatory BP monitor (ABPM) for 24 h and fasting blood was taken. Subjects then consumed concentrated beetroot juice (12...
January 3, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28046156/feed-intake-growth-and-body-and-carcass-attributes-of-feedlot-steers-supplemented-with-two-levels-of-calcium-nitrate-or-urea
#19
R S Hegarty, J Miller, N Oelbrandt, L Li, J P M Luijben, D L Robinson, J V Nolan, H B Perdok
Nitrate supplementation has been shown to be effective in reducing enteric methane emission from ruminants, but there have been few large-scale studies assessing the effects of level of nitrate supplementation on feed intake, animal growth, or carcass and meat quality attributes of beef cattle. A feedlot study was conducted to assess the effects of supplementing 0.25 or 0.45% NPN in dietary DM as either urea (Ur) or calcium nitrate (CaN) on DMI, ADG, G:F, and carcass attributes of feedlot steers ( = 383). The levels of NPN inclusion were selected as those at which nitrate has previously achieved measurable mitigation of enteric methane...
December 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/28042082/beetroot-juice-versus-chard-gel-a-pharmacokinetic-and-pharmacodynamic-comparison-of-nitrate-bioavailability
#20
Luke C McIlvenna, Chris Monaghan, Luke Liddle, Bernadette O Fernandez, Martin Feelisch, David J Muggeridge, Chris Easton
Dietary supplementation with inorganic nitrate (NO3(-)) has been shown to induce a multitude of advantageous cardiovascular and metabolic responses during rest and exercise. While there is some suggestion that pharmacokinetics may differ depending on the NO3(-) source ingested, to the best of our knowledge this has yet to be determined experimentally. Here, we compare the plasma pharmacokinetics of NO3(-), nitrite (NO2(-)), and total nitroso species (RXNO) following oral ingestion of either NO3(-) rich beetroot juice (BR) or chard gels (GEL) with the associated changes in blood pressure (BP)...
December 29, 2016: Nitric Oxide: Biology and Chemistry
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