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Breast cancer luminal b

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https://www.readbyqxmd.com/read/29220095/digital-image-analysis-of-ki67-in-hot-spots-is-superior-to-both-manual-ki67-and-mitotic-counts-in-breast-cancer
#1
Gustav Stålhammar, Stephanie Robertson, Lena Wedlund, Michael Lippert, Mattias Rantalainen, Jonas Bergh, Johan Hartman
AIMS: During pathological examination of breast tumours, proliferative activity is routinely evaluated by a count of mitoses. Adding immunohistochemical stains of Ki67 provides extra prognostic and predictive information. However, currently used methods for these evaluations suffer from imperfect reproducibility. It is still unclear whether analysis of Ki67 should be performed in hot spots, in the tumour periphery or as an average of the whole tumour section. In this paper, we compare the clinical relevance of mitoses, Ki67 and Phosphohistone H3 in two cohorts of primary breast cancer specimens (total n=294)...
December 8, 2017: Histopathology
https://www.readbyqxmd.com/read/29216710/a-novel-prognostic-nomogram-for-predicting-risks-of-distant-failure-in-patients-with-invasive-breast-cancer-following-postoperative-adjuvant-radiotherapy
#2
Yu Jin Lim, Sea-Won Lee, Noorie Choi, Jeanny Kwon, Keun-Yong Eom, Eunyoung Kang, Eun-Kyu Kim, Jee Hyun Kim, Yu Jung Kim, Se Hyun Kim, So Yeon Park, In Ah Kim
Purpose: This study aimed to identify predictors for distant metastatic behavior and build a related prognostic nomogram in breast cancer. Materials and Methods: A total of 1,181 patients with non-metastatic breast cancer between 2003 and 2011 were analyzed. To predict the probability of distant metastasis, a nomogram was constructed based on prognostic factors identified using a Cox proportional hazards model. Results: The 7-year overall survival and 5-year post-progression survival of locoregional vs...
December 7, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29212525/establishing-and-characterizing-patient-derived-xenografts-using-pre-chemotherapy-percutaneous-biopsy-and-post-chemotherapy-surgical-samples-from-a-prospective-neoadjuvant-breast-cancer-study
#3
Jia Yu, Bo Qin, Ann M Moyer, Jason P Sinnwell, Kevin J Thompson, John A Copland, Laura A Marlow, James L Miller, Ping Yin, Bowen Gao, Katherine Minter-Dykhouse, Xiaojia Tang, Sarah A McLaughlin, Alvaro Moreno-Aspitia, Anthony Schweitzer, Yan Lu, Jason Hubbard, Donald W Northfelt, Richard J Gray, Katie Hunt, Amy L Conners, Vera J Suman, Krishna R Kalari, James N Ingle, Zhenkun Lou, Daniel W Visscher, Richard Weinshilboum, Judy C Boughey, Matthew P Goetz, Liewei Wang
BACKGROUND: Patient-derived xenografts (PDXs) are increasingly used in cancer research as a tool to inform cancer biology and drug response. Most available breast cancer PDXs have been generated in the metastatic setting. However, in the setting of operable breast cancer, PDX models both sensitive and resistant to chemotherapy are needed for drug development and prospective data are lacking regarding the clinical and molecular characteristics associated with PDX take rate in this setting...
December 6, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29211792/the-prognostic-role-of-tumor-size-in-early-breast-cancer-in-the-era-of-molecular-biology
#4
Anaid Anna Kasangian, Giorgio Gherardi, Elena Biagioli, Valter Torri, Anna Moretti, Elena Bernardin, Andrea Cordovana, Gabriella Farina, Annalisa Bramati, Sheila Piva, Maria Chiara Dazzani, Emanuela Paternò, Nicla Maria La Verde
BACKGROUND: The prognosis of early breast cancer (EBC) depends on patient and tumor characteristics. The association between tumor size, the largest diameter in TNM staging, and prognosis is well recognized. According to TNM, tumors classified as T2, could have very different volumes; e.g. a tumor of 2.1 cm has a volume of 4500 mm3, while a tumor of 4.9 cm has a volume of 60.000 mm3 even belonging to the same class. The aim of the study is to establish if the prognostic role of tumor size, expressed as diameter and volume, has been overshadowed by other factors...
2017: PloS One
https://www.readbyqxmd.com/read/29207087/p-stat3-in-luminal-breast-cancer-integrated-rna-protein-pooled-analysis-and-results-from-the-big-2-98-phase-iii-trial
#5
Amir Sonnenblick, Roberto Salgado, Sylvain Brohée, Tamar Zahavi, Tamar Peretz, Gert Van den Eynden, Ghizlane Rouas, Asher Salmon, Prudence A Francis, Angelo Di Leo, John P A Crown, Giuseppe Viale, Laura Daly, Bahar Javdan, Sho Fujisawa, Evandro De Azambuja, Ameye Lieveke, Martine J Piccart, Jacqueline F Bromberg, Christos Sotiriou
In the present study, in order to investigate the role of signal transducer and activator of transcription 3 (STAT3) in estrogen receptor (ER)-positive breast cancer prognosis, we evaluated the phosphorylated STAT3 (p-STAT3) status and investigated its effect on the outcome in a pooled analysis and in a large prospective adjuvant trial. By using the TCGA repository, we developed gene signatures that reflected the level of p-STAT3. Using pooled analysis of the expression data from luminal breast cancer patients, we assessed the effects of the p-STAT3 expression signature on prognosis...
November 27, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29204123/network-modularity-in-breast-cancer-molecular-subtypes
#6
Sergio Antonio Alcalá-Corona, Guillermo de Anda-Jáuregui, Jesús Espinal-Enríquez, Enrique Hernández-Lemus
Breast cancer is a heterogeneous and complex disease, a clear manifestation of this is its classification into different molecular subtypes. On the other hand, gene transcriptional networks may exhibit different modular structures that can be related to known biological processes. Thus, modular structures in transcriptional networks may be seen as manifestations of regulatory structures that tightly controls biological processes. In this work, we identify modular structures on gene transcriptional networks previously inferred from microarray data of molecular subtypes of breast cancer: luminal A, luminal B, basal, and HER2-enriched...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29202622/an-inter-observer-ki67-reproducibility-study-applying-two-different-assessment-methods-on-behalf-of-the-danish-scientific-committee-of-pathology-danish-breast-cancer-cooperative-group-dbcg
#7
Anne-Vibeke Laenkholm, Dorthe Grabau, Maj-Lis Møller Talman, Eva Balslev, Anne Marie Bak Jylling, Tomasz Piotr Tabor, Morten Johansen, Anja Brügmann, Giedrius Lelkaitis, Tina Di Caterino, Henrik Mygind, Thomas Poulsen, Henrik Mertz, Gorm Søndergaard, Birgitte Bruun Rasmussen
INTRODUCTION: In 2011, the St. Gallen Consensus Conference introduced the use of pathology to define the intrinsic breast cancer subtypes by application of immunohistochemical (IHC) surrogate markers ER, PR, HER2 and Ki67 with a specified Ki67 cutoff (>14%) for luminal B-like definition. Reports concerning impaired reproducibility of Ki67 estimation and threshold inconsistency led to the initiation of this quality assurance study (2013-2015). The aim of the study was to investigate inter-observer variation for Ki67 estimation in malignant breast tumors by two different quantification methods (assessment method and count method) including measure of agreement between methods...
December 5, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29199716/pattern-of-distant-metastasis-in-molecular-subtypes-of-carcinoma-breast-an-institutional-study
#8
S U Kunikullaya, J Poddar, A D Sharma, S Patel
BACKGROUND: Molecular subtypes of carcinoma breast show a particular pattern of distant metastasis, the knowledge of which can help to diagnose and intervene early in the course of the disease. AIM: The aim of this study was to investigate and establish an association between the molecular subtypes of carcinoma breast and the pattern of distant metastasis. SETTINGS AND DESIGN: Single arm, retrospective study. MATERIALS AND METHODS: Totally 400 patients of carcinoma breast (Stage I and II) were selected who were treated between January 2010 and December 2013...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29193094/expression-of-programmed-death-1-in-sentinel-lymph-nodes-of-breast-cancer
#9
Takashi Tatara, Toru Mukohara, Yohei Shimono, Takashi Yamasaki, Yoshinori Imamura, Yohei Funakoshi, Masanori Toyoda, Naomi Kiyota, Shintaro Takao, Seishi Kono, Yoshihiro Kakeji, Hironobu Minami
BACKGROUND AND OBJECTIVES: To explore whether lymphocytes in sentinel lymph nodes (SLNs) are highly exposed to tumor neoantigens and thus express high level of programmed death 1 (PD-1), we examined PD-1 expression in SLNs and non-sentinel regional lymph nodes (non-SLNs) in breast cancer. METHODS: We performed PD-1 immunohistochemistry in two cohorts: 40 metastasis-negative SLNs including 10 patients for each subtype (luminal A-like, luminal B-like, HER2, and triple negative breast cancer [TNBC]); and 25 pairs of metastasis-positive SLNs and non-SLNs (10 luminal A-like, 10 luminal B-like, and 5 TNBC)...
November 28, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29191181/immunohistochemistry-defined-subtypes-of-breast-cancer-in-678-sudanese-and-eritrean-women-hospitals-based-case-series
#10
Asmerom Tesfamariam Sengal, Nada Suliman Haj-Mukhtar, Ahmed Mohammed Elhaj, Shahinaz Bedri, Eva Johanna Kantelhardt, Ahmed A Mohamedani
BACKGROUND: Breast cancer is the most common malignancy accounting for 25% of all cancers in females. In Africa, breast cancer prevalence and mortality are steadily increasing. Knowledge of hormone receptors and human epidermal growth factor receptor-2 (HER-2) expressions are vital for breast cancer management plans and decision making. There is wide regional variation in the proportion of these biomarkers, especially in African countries. Hormone receptors positivity in indigenous African and African American women is considered to be low and triple negative breast cancer is a dominant phenotype...
December 1, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29190923/prognostic-values-of-distinct-cbx-family-members-in-breast-cancer
#11
Yuan-Ke Liang, Hao-Yu Lin, Chun-Fa Chen, De Zeng
Chromobox (CBX) family proteins are canonical components in polycomb repressive complexes 1 (PRC1), with epigenetic regulatory function and transcriptionally repressing target genes via chromatin modification. A plethora of studies have highlighted the function specifications among CBX family members in various cancer, including lung cancer, colon cancer and breast cancer. Nevertheless, the functions and prognostic roles of distinct CBX family members in breast cancer (BC) remain elusive. In this study, we reported the prognostic values of CBX family members in patients with BC through analysis of a series of databases, including CCLE, ONCOMINE, Xena Public Data Hubs, and Kaplan-Meier plotter...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29176871/effect-of-radiotherapy-on-activity-and-concentration-of-serum-paraoxonase-1-in-breast-cancer-patients
#12
Meritxell Arenas, Anabel García-Heredia, Noemí Cabré, Fedra Luciano-Mateo, Anna Hernández-Aguilera, Sebastià Sabater, Marta Bonet, Marina Gascón, Salvador Fernández-Arroyo, Isabel Fort-Gallifa, Jordi Camps, Jorge Joven
Paraoxonase-1 (PON1) is an intra-cellular antioxidant enzyme found also in the circulation associated with high-density lipoproteins. The activity of this enzyme has been shown to be decreased in breast cancer (BC) patients. The aims of our study were to investigate the changes produced by radiotherapy (RT) on activity and concentration of serum PON1 in BC patients, and to evaluate the observed variations in relation to clinical and pathological characteristics of patients and tumors, and the response to treatment...
2017: PloS One
https://www.readbyqxmd.com/read/29176653/estrogen-induces-c-kit-and-an-aggressive-phenotype-in-a-model-of-invasive-lobular-breast-cancer
#13
J Chuck Harrell, Thomas M Shroka, Britta M Jacobsen
Among the molecular subtypes of breast cancer are luminal (A or B) estrogen receptor positive (ER+), HER2+, and triple negative (basal-like). In addition to the molecular subtypes, there are 18 histologic breast cancer subtypes classified on appearance, including invasive lobular breast carcinoma (ILC), which are 8-15% of all breast cancers and are largely ER+ tumors. We used a new model of ER+ ILC, called BCK4. To determine the estrogen regulated genes in our ILC model, we examined BCK4 xenograft tumors from mice supplemented with or without estrogen using gene expression arrays...
November 27, 2017: Oncogenesis
https://www.readbyqxmd.com/read/29172851/intrinsic-subtypes-and-benefit-from-postmastectomy-radiotherapy-in-node-positive-premenopausal-breast-cancer-patients-who-received-adjuvant-chemotherapy-results-from-two-independent-randomized-trials
#14
Tinne Laurberg, Trine Tramm, Torsten Nielsen, Jan Alsner, Silje Nord, Simen Myhre, Therese Sørlie, Samuel Leung, Cheng Fan, Charles Perou, Karen Gelmon, Jens Overgaard, David Voduc, Aleix Prat, Maggie Chon U Cheang
BACKGROUND: The study of the intrinsic molecular subtypes of breast cancer has revealed differences among them in terms of prognosis and response to chemotherapy and endocrine therapy. However, the ability of intrinsic subtypes to predict benefit from adjuvant radiotherapy has only been examined in few studies. METHODS: Gene expression-based intrinsic subtyping was performed in 228 breast tumors collected from two independent post-mastectomy clinical trials (British Columbia and the Danish Breast Cancer Cooperative Group 82b trials), where pre-menopausal patients with node-positive disease were randomized to adjuvant radiotherapy or not...
November 25, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29169183/myc-regulation-of-glutamine-proline-regulatory-axis-is-key-in-luminal-b-breast-cancer
#15
Madeleine L Craze, Hayley Cheung, Natasha Jewa, Nuno D M Coimbra, Daniele Soria, Rokaya El-Ansari, Mohammed A Aleskandarany, Kiu Wai Cheng, Maria Diez-Rodriguez, Christopher C Nolan, Ian O Ellis, Emad A Rakha, Andrew R Green
BACKGROUND: Altered cellular metabolism is a hallmark of cancer and some are reliant on glutamine for sustained proliferation and survival. We hypothesise that the glutamine-proline regulatory axis has a key role in breast cancer (BC) in the highly proliferative classes. METHODS: Glutaminase (GLS), pyrroline-5-carboxylate synthetase (ALDH18A1), and pyrroline-5-carboxylate reductase 1 (PYCR1) were assessed at DNA/mRNA/protein levels in large, well-characterised cohorts...
November 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29168407/mortality-and-recurrence-rates-among-systemically-untreated-high-risk-breast-cancer-patients-included-in-the-dbcg-77-trials
#16
Maj-Britt Jensen, Torsten O Nielsen, Ann S Knoop, Anne-Vibeke Laenkholm, Eva Balslev, Bent Ejlertsen
BACKGROUND: Following loco-regional treatment for early breast cancer accurate prognostication is essential for communicating benefits of systemic treatment. The aim of this study was to determine time to recurrence and long-term mortality rates in high risk patients according to patient characteristics and subtypes as assigned by immunohistochemistry panels. PATIENTS AND METHODS: In November 1977 through January 1983, 2862 patients with tumors larger than 5 cm or positive axillary nodes were included in the DBCG 77 trials...
November 23, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29162724/progesterone-receptor-a-promotes-invasiveness-and-metastasis-of-luminal-breast-cancer-by-suppressing-regulation-of-critical-micro-rnas-by-estrogen
#17
Thomas McFall, Brooke McKnight, Rayna Rosati, Seongho Kim, Yanfang Huang, Nerissa Viola-Villegas, Manohar Ratnam
Distal metastasis of luminal breast cancer is frequent and incurable, yet the metastasis mechanisms are poorly understood. Estrogen, even at postmenopausal concentrations, suppresses invasiveness of luminal breast cancer cells through the estrogen receptor (ER). Invasive tumors overexpress the short progesterone receptor A (PR-A) isoform. Even at postmenopausal concentrations, progesterone activates PR-A, inducing invasiveness by counteracting estrogens effects, particularly when cells are hyper-sensitized to progesterone by PR-A overexpression...
November 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29159760/body-mass-index-age-at-breast-cancer-diagnosis-and-breast-cancer-subtype-a-cross-sectional-study
#18
O Brouckaert, K Van Asten, A Laenen, A Soubry, A Smeets, I Nevelstreen, I Vergote, H Wildiers, R Paridaens, E Van Limbergen, C Weltens, P Moerman, G Floris, P Neven
PURPOSE: Evidence suggests that premenopausal obesity decreases and postmenopausal obesity increases breast cancer risk. Because it is not well known whether this is subtype dependent, we studied the association between body mass index (BMI) and age at breast cancer diagnosis, or the probability of being diagnosed with a specific breast cancer phenotype, by menopausal status. METHODS: All patients with non-metastatic operable breast cancer from the University Hospital Leuven diagnosed between January 1, 2000 and December 31, 2013 were included (n = 7020) in this cross-sectional study...
November 20, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29146102/outcomes-by-molecular-subtype-after-accelerated-partial-breast-irradiation-using-single-entry-catheters
#19
Aman Saini, Robert Kuske, Coral Quiet, Cheri Pantoja, Daniel Reed, Victor Zannis
PURPOSE: Tumor biology is being recognized as an important indicator of prognosis and risk of locoregional recurrence. Here, we determine actuarial recurrence rates by approximated molecular subtype for women treated with single-entry catheter accelerated partial breast irradiation (sAPBI). METHODS AND MATERIALS: One thousand four hundred eighty-six women with invasive cancer having known ER, PR, and Her2 status and at least 1-year of followup were treated using MammoSite, Contura, or SAVI sAPBI from 2002 to 2014 at our institution...
November 13, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29144790/evaluation-of-ki-67-index-in-core-needle-biopsies-and-matched-breast-cancer-surgical-specimens
#20
Soomin Ahn, Junghye Lee, Min-Sun Cho, Sanghui Park, Sun Hee Sung
CONTEXT: - The Ki-67 index is strongly prognostic and is used as a surrogate marker to distinguish luminal A from luminal B breast cancer types. OBJECTIVE: - To investigate differences in Ki-67 index between core needle biopsy samples and matched surgical samples in breast cancer. DESIGN: - We included patients with invasive breast cancer who did not receive neoadjuvant therapy. A total of 89 pairs of core needle biopsies and surgical specimens were collected, and the Ki-67 index was assessed in hot spot areas using an image analyzer...
November 16, 2017: Archives of Pathology & Laboratory Medicine
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