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Breast cancer luminal b

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https://www.readbyqxmd.com/read/29444670/breast-cancer-in-ethiopia-evidence-for-geographic-difference-in-the-distribution-of-molecular-subtypes-in-africa
#1
Endale Hadgu, Daniel Seifu, Wondemagegnhu Tigneh, Yonas Bokretsion, Abebe Bekele, Markos Abebe, Thomas Sollie, Sofia D Merajver, Christina Karlsson, Mats G Karlsson
BACKGROUND: Breast cancer is a heterogeneous disease with several morphological and molecular subtypes. Widely accepted molecular classification system uses assessment of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and proliferation marker Ki67. Few studies have been conducted on the incidence and molecular types of breast cancer in Sub-Saharan Africa. Previous studies mainly from Western and Central Africa, showed breast cancer to occur at younger ages and to present with aggressive features, such as high-grade, advanced stage and triple-negative phenotype (negative for ER, PR and HER2)...
February 14, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29439457/immune-landscape-of-breast-cancers
#2
REVIEW
Divya Nagarajan, Stephanie E B McArdle
Breast cancer is a very heterogeneous disease, both at a molecular and a histological level. Five intrinsic subtypes were initially identified-Luminal-A, Luminal-B, HER2⁺, Triple negative/basal like (TNBC) and normal like-subsequently expanded to seven (Basal-like-1 and 2, mesenchymal, mesenchymal stem-like, luminal androgen receptor, immuno-modulatory and unstable). Although genetic and epigenetic changes are key pathogenic events, the immune system plays a substantial role in promoting progression and metastasis...
February 11, 2018: Biomedicines
https://www.readbyqxmd.com/read/29436376/breast-carcinoma-in-sclerosing-adenosis-a-clinicopathological-and-immunophenotypical-analysis-on-206-lesions
#3
Bao-Hua Yu, Shao-Xian Tang, Xiao-Li Xu, Yu-Fan Cheng, Rui Bi, Ruo-Hong Shui, Xiao-Yu Tu, Hong-Fen Lu, Xiao-Yan Zhou, Wen-Tao Yang
AIMS: To fully elucidate the clinicopathological features of breast carcinoma in sclerosing adenosis (SA-BC). METHODS: Clinical and histological characteristics of 206 SA-BCs from 180 patients were retrospectively evaluated. Immunohistochemical phenotype was examined. The clinicopathological relevance of the topographical pattern of SA-BCs was analysed. RESULTS: Overall, up to 46 patients (25.6%) had contralateral cancer, either SA associated or not...
February 7, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29423901/impact-of-physiological-hormonal-fluctuations-on-18f-fluorodeoxyglucose-uptake-in-breast-cancer
#4
Kanae K Miyake, Yuji Nakamoto, Shigehira Saji, Tomoharu Sugie, Kensuke Kurihara, Shotaro Kanao, Debra M Ikeda, Masakazu Toi, Kaori Togashi
PURPOSE: Premenopausal physiologic steroid levels change cyclically, in contrast to steady state low levels seen in postmenopausal patients. The purpose of this study was to evaluate whether 18F-fluorodeoxyglucose (18F-FDG) uptake in breast cancer is influenced by physiological hormonal fluctuations. METHODS: A total of 160 primary invasive breast cancers from 155 females (54 premenopausal, 101 postmenopausal) who underwent 18F-FDG positron emission tomography/computed tomography before therapy were retrospectively analyzed...
February 8, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29423058/muc1-induces-m2-type-macrophage-influx-during-postpartum-mammary-gland-involution-and-triggers-breast-cancer
#5
Yuan Li, Zhi Pang, Xinran Dong, Xiaodong Liao, Huayun Deng, Chunhua Liao, Yahui Liao, Guoqiang Chen, Lei Huang
The microenvironment of postpartum mammary gland involution (PMI) has been linked to the increased risk of breast cancer and poor outcome of patients. Nevertheless the mechanism underlying regulates the microenvironment remains largely unknown. MUC1, which is abnormally overexpressed in most breast cancer, is physiologically expressed in PMI. Using MUC1 cytoplasm domain (MUC1-CD) transgenic mice, we reveal that the overexpression of MUC1-CD in mammary epithelial cells increases M2 type macrophage infiltration in PMI...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29416660/foxm1-is-a-promising-candidate-target-in-the-treatment-of-breast-cancer
#6
Xiao-Feng Lu, De Zeng, Wei-Quan Liang, Chun-Fa Chen, Shu-Ming Sun, Hao-Yu Lin
Forkhead box protein M1(FoxM1) is a member of forkhead superfamily transcription factors. Emerging evidences have progressively contributed to our understanding on a central role of FoxM1 in human cancers. However, perspectives on the function of FoxM1 in breast cancer (BC) remain conflicting, and mostly were from basic research. Here, we explored the expression profile and prognostic values of FoxM1 based on analysis of pooled clinical datasets derived from online accessible databases, including ONCOMINE , Breast Cancer Gene-Expression Miner v4...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29409530/frequency-of-breast-cancer-subtypes-among-african-american-women-in-the-amber-consortium
#7
Emma H Allott, Joseph Geradts, Stephanie M Cohen, Thaer Khoury, Gary R Zirpoli, Wiam Bshara, Warren Davis, Angela Omilian, Priya Nair, Rochelle P Ondracek, Ting-Yuan David Cheng, C Ryan Miller, Helena Hwang, Leigh B Thorne, Siobhan O'Connor, Traci N Bethea, Mary E Bell, Zhiyuan Hu, Yan Li, Erin L Kirk, Xuezheng Sun, Edward A Ruiz-Narvaez, Charles M Perou, Julie R Palmer, Andrew F Olshan, Christine B Ambrosone, Melissa A Troester
BACKGROUND: Breast cancer subtype can be classified using standard clinical markers (estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2)), supplemented with additional markers. However, automated biomarker scoring and classification schemes have not been standardized. The aim of this study was to optimize tumor classification using automated methods in order to describe subtype frequency in the African American Breast Cancer Epidemiology and Risk (AMBER) consortium...
February 6, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29394674/-a-case-of-stage-iv-breast-cancer-with-extensive-metastasis-successfully-treated-with-s-1-plus-anastrozole-therapy
#8
Tatsuro Mugitani, Tomoya Hatakeyama, Toshinori Sakai, Atsushi Matsumura, Shiro Ogino, Toshikazu Akami, Shinji Okano
We report the case of a patient in which S-1 plus anastrozole was administered as first-line chemotherapy for Stage IV breast cancer with skin invasion, multiple lymph node metastasis, and lymphangitis carcinomatosis. A 77-year-old woman had a mass destroyed immediately outside the axilla with dry coughs. An 11mm unpalpable mass in the right breast and an axillary mass were confirmed to be scirrhous carcinoma(Luminal type B), respectively, by core needle biopsy. In one course, S- 1(100mg/day)therapy involves taking 2 courses of 14 days of administration and 7 days off the drug...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394534/-local-control-of-advanced-breast-cancer-with-giant-ulcer
#9
Tomoo Inoue, Atsushi Shimomura, Takuji Sugimoto, Shiori Wakamiya, Ukou Chou, Akira Fujiwara, Fumihiro Uchikoshi, Tarou Watanabe, Natsuko Kitamura
This study reports the treatment and local control of advanced breast cancer with a giant ulcer. A 53-year-old woman presented with a large left breast tumor and an associated giant ulcer, with massive exudates, bleeding, and an offensive odor. Histopathological examination revealed an invasive ductal carcinoma(Luminal B type). Computed tomography(CT) showed multiple metastases to the lymph nodes, lungs, liver and bones. The patient received chemotherapy with a combina- tion of paclitaxel(PTX 90mg/m / 2)and bevacizumab(BEV 10 mg/kg)...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394271/barriers-to-early-presentation-of-breast-cancer-among-women-in-soweto-south-africa
#10
Maureen Joffe, Oluwatosin Ayeni, Shane Anthony Norris, Valerie Ann McCormack, Paul Ruff, Ishani Das, Alfred I Neugut, Judith S Jacobson, Herbert Cubasch
PURPOSE: Reported breast cancer incidence is rising in South Africa, where some women are diagnosed late and have poor outcomes. We studied patient and provider factors associated with clinical stage at diagnosis among women diagnosed at the Chris Hani Baragwanath Academic Hospital in Soweto, Johannesburg in 2015-2016. METHODS: From face-to-face interviewer-administered questionnaires we compared self-reported socioeconomics, demographics, comorbidities, risk factors, personal and health system barriers, and from patient clinical records, clinical staging, receptor subtype, and tumor grade among 499 consecutive women newly diagnosed with advanced stage (III/IV) breast cancer versus those diagnosed early (stage 0/I/II)...
2018: PloS One
https://www.readbyqxmd.com/read/29388117/correlation-of-fancm-expression-with-clinical-factors-in-luminal-b-breast-cancer
#11
Yiran Wang, Junnan Wang, Fei Long, Ning Wang, Bingbing Zhang, Huan Han, Yajie Wang
BACKGROUND: The genotype of Fanconi Anemia complementation group M (FANCM) was previously found to be associated with breast cancer risk in several populations. Here, we studied the expression of FANCM and its correlation with clinical characteristics in Chinese patients with breast cancer. METHODS: We performed an immunohistochemical study of FANCM protein in clinical breast cancer tissues from 310 patients along with 44 adjacent tissues. RESULTS: FANCM protein level is lower in triple-negative breast cancer tissues than in other subtypes (P = 0...
January 31, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29388017/systematical-analysis-of-lncrna-mrna-competing-endogenous-rna-network-in-breast-cancer-subtypes
#12
Shunheng Zhou, Lihong Wang, Qian Yang, Haizhou Liu, Qianqian Meng, Leiming Jiang, Shuyuan Wang, Wei Jiang
BACKGROUND: Breast cancer is one of the most common solid tumors in women involving multiple subtypes. However, the mechanism for subtypes of breast cancer is still complicated and unclear. Recently, several studies indicated that long non-coding RNAs (lncRNAs) could act as sponges to compete miRNAs with mRNAs, participating in various biological processes. METHODS: We concentrated on the competing interactions between lncRNAs and mRNAs in four subtypes of breast cancer (basal-like, HER2+, luminal A and luminal B), and analyzed the impacts of competing endogenous RNAs (ceRNAs) on each subtype systematically...
February 1, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29383138/sf3b1-mutation-is-a-poor-prognostic-indicator-in-luminal-b-and-progesterone-receptor-negative-breast-cancer-patients
#13
Xing Fu, Ming Tian, Jia Gu, Teng Cheng, Ding Ma, Ling Feng, Xing Xin
The purpose of this study was to explore the relationship between SF3B1 mutations and the prognoses of patients with breast cancer. Clinical and SF3B1 mutation data from The Cancer Genome Atlas were analyzed. SF3B1 mutations were evaluated as prognostic factors in all breast cancer patients and specific subgroups through Cox regression and Kaplan-Meier analyses. We also investigated the relationship between traditional parameters and SF3B1 mutations. Receiver operating characteristics curves were used to analyze common risk factors for their sensitivity and specificity in predicting SF3B1 mutations...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29373911/can-histological-grade-and-mitotic-index-replace-ki67-to-determine-luminal-breast-cancer-subtypes
#14
David Oddó, Dahiana Pulgar, Nicole Elgueta, Francisco Acevedo, Dravna Razmiliz, María Elena Navarro, Mauricio Camus, Tomás Merino, Ignacio Retamal, Alejandra Pérez-Sepúlveda, Alejandra Villarroel, Héctor Galindo, José Peña, César Sánchez
Introduction: Breast cancer can be classified into subtypes based on immunohistochemical markers, with Ki67 expression levels being used to divide luminal BC tumors in luminal A and B subtypes; however, Ki67 is not routinely determined due to a lack of standardization. Objective: To evaluate histological grade and Eliminate: the mitotic index to determine if they can be used as an alternative method to Ki67 staining for luminal subtype definition. Methods: We evaluated estrogen receptor positive breast cancer tissue samples...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29371916/the-il-17b-il-17-receptor-b-pathway-promotes-resistance-to-paclitaxel-in-breast-tumors-through-activation-of-the-erk1-2-pathway
#15
Emilie Laprevotte, Stéphanie Cochaud, Stanislas du Manoir, Marion Lapierre, Cécile Dejou, Marion Philippe, Jérome Giustiniani, Kathryn A Frewer, Andrew J Sanders, Wen G Jiang, Henri-Alexandre Michaud, Pierre-Emmanuel Colombo, Armand Bensussan, Gilles Alberici, Jérémy Bastid, Jean-François Eliaou, Nathalie Bonnefoy
Interleukin 17B (IL-17B) is a pro-inflammatory cytokine that belongs to the IL-17 cytokines family and binds to IL-17 receptor B (IL-17RB). Here we found that high expression of IL-17B and IL-17RB is associated with poor prognosis in patients with breast cancer and that IL-17B expression upregulation is specifically associated with poorer survival in patients with basal-like breast cancer. We thus focused on IL-17B role in breast cancer by using luminal and triple negative (TN)/basal-like tumor cell lines. We found that IL-17B induces resistance to conventional chemotherapeutic agents...
December 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/29369732/pam50-risk-of-recurrence-score-predicts-10-year-distant-recurrence-in-a-comprehensive-danish-cohort-of-postmenopausal-women-allocated-to-5-years-of-endocrine-therapy-for-hormone-receptor-positive-early-breast-cancer
#16
Anne-Vibeke Lænkholm, Maj-Britt Jensen, Jens Ole Eriksen, Birgitte Bruun Rasmussen, Ann S Knoop, Wesley Buckingham, Sean Ferree, Carl Schaper, Torsten O Nielsen, Taryn Haffner, Torben Kibøl, Maj-Lis Møller Talman, Anne Marie Bak Jylling, Tomasz Piotr Tabor, Bent Ejlertsen
Purpose The PAM50-based Prosigna risk of recurrence (ROR) score has been validated in randomized clinical trials to predict 10-year distant recurrence (DR). The value of Prosigna for predicting DR was examined in a comprehensive nationwide Danish cohort consisting of postmenopausal women with hormone receptor-positive early breast cancer treated with 5 years of endocrine therapy alone. Patients and Methods Using the population-based Danish Breast Cancer Cooperative Group database, follow-up data were collected on all patients diagnosed from 2000 through 2003 who, by nationwide guidelines, were treated with endocrine therapy for 5 years...
January 25, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29365416/-mri-findings-and-pathological-features-of-occult-breast-cancer
#17
J J Zhang, X T Yang, X S Du, J X Zhang, L N Hou, J L Niu
Objective: To investigate the magnetic resonance imaging (MRI) findings and clinicopathological features of primary lesions in patients with occult breast cancer (OBC). Methods: The imaging reports from the Breast Imaging Reporting and Data System in 2013 were retrospectively analyzed to investigate the morphology and the time signal intensity curve (TIC) of breast lesions in patients with OBC. The clinical and pathological characteristics of these patients were also included. Results: A total of 34 patients were enrolled...
January 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29363543/anti-estrogen-therapy-increases-plasticity-and-cancer-stemness-of-prolactin-induced-er%C3%AE-mammary-carcinomas
#18
Michael P Shea, Kathleen A O'Leary, Saja A Fakhraldeen, Vincent Goffin, Andreas Friedl, Kari B Wisinski, Caroline M Alexander, Linda A Schuler
Although anti-estrogen therapies are successful in many patients with estrogen receptor alpha-positive (ERα+) breast cancer, 25-40% fail to respond. Although multiple mechanisms underlie evasion of these treatments, including tumor heterogeneity and drug-resistant cancer stem cells (CSCs), further investigations have been limited by the paucity of preclinical ERα+ tumor models. Here we examined a mouse model of prolactin-induced aggressive ERα+ breast cancer, which mimics the epidemiologic link between prolactin exposure and increased risk for metastatic ERα+ tumors...
January 23, 2018: Cancer Research
https://www.readbyqxmd.com/read/29361955/intracystic-papillary-carcinoma-of-the-male-breast-a-case-report
#19
Haruhito Kinoshita, Shinichiro Kashiwagi, Hitoshi Teraoka, Takuya Mori, Kenji Kuroda, Mikio Nanbara, Eiji Noda, Takaaki Chikugo, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: Intracystic papillary carcinoma (IPC) is defined as cancer that develops from the wall of a cyst in the breast. As breast cancer in men accounts for only 1% of all breast cancers, male IPC is an extremely rare form of the disease. The present case report examines IPC in a man, along with an in-depth literature discussion. CASE PRESENTATION: A 64-year-old Japanese man noticed a mass in the right breast and sought medical attention. An elastic and soft neoplastic 3-cm lesion was palpated in the right papilla...
January 23, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29359949/comparison-of-peritumoral-stromal-tissue-stiffness-obtained-by-shear-wave-elastography-between-benign-and-malignant-breast-lesions
#20
Hye Sun Park, Hee Jung Shin, Ki Chang Shin, Joo Hee Cha, Eun Young Chae, Woo Jung Choi, Hak Hee Kim
Background Aggressive breast cancers produce abnormal peritumoral stiff areas, which can differ between benign and malignant lesions and between different subtypes of breast cancer. Purpose To compare the tissue stiffness of the inner tumor, tumor border, and peritumoral stroma (PS) between benign and malignant breast masses by shear wave elastography (SWE). Material and Methods We enrolled 133 consecutive patients who underwent preoperative SWE. Using OsiriX commercial software, we generated multiple 2-mm regions of interest (ROIs) in a linear arrangement on the inner tumor, tumor border, and PS...
January 1, 2018: Acta Radiologica
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