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https://www.readbyqxmd.com/read/28944729/using-performance-based-risk-sharing-arrangements-to-address-uncertainty-in-indication-based-pricing
#1
Kai Yeung, Meng Li, Josh J Carlson
BACKGROUND: The rise in pharmaceutical expenditures in recent years has increased health care payer interest in ensuring good value for the money. Indication-based pricing (IBP) sets separate, indication-specific prices paid to the manufacturer according to the expected efficacy of a drug in each of its indications. IBP allows payers to consistently pay for value across indications. While promising, a limitation of IBP as originally conceived is that efficacy estimates are typically based on clinical trial data, which may differ from real-world effectiveness...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28917602/comparing-inpatient-versus-outpatient-bowel-preparation-in-children-and-adolescents-undergoing-appendicovesicostomy
#2
David L Weatherly, Konrad M Szymanski, Benjamin M Whittam, William E Bennett, Shelly King, Rosalia Misseri, Martin Kaefer, Richard C Rink, Mark P Cain
PURPOSE: The need for mechanical inpatient bowel preparation (IBP) in reconstructive pediatric urology has come under scrutiny, secondary to literature demonstrating little benefit regarding outcomes. Starting in 2013, a majority of patients undergoing reconstructive procedures at our institution no longer underwent IBP. We hypothesized that outpatient bowel preparation (OBP) would reduce length of stay (LOS) without increasing postoperative complications after appendicovesicostomy surgery...
August 26, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28905097/color-doppler-and-spectral-doppler-ultrasound-detection-of-active-sacroiliitis-in-spondyloarthritis-compared-to-physical-examination-as-gold-standard
#3
Concepción Castillo-Gallego, Eugenio De Miguel, Miriam García-Arias, Chamaida Plasencia, Leticia Lojo-Oliveira, Emilio Martín-Mola
Sacroiliac joint (SIJ) involvement is a distinctive feature of spondyloarthritis (SpA). The main objective of this study was to assess the validity of color Doppler ultrasound (CDUS) in SIJ. This was a cross-sectional, blinded, case-control study of 108 cases divided into three groups: (a) 53 SpA patients with inflammatory back pain (IBP); (b) 28 SpA patients with no IBP; and (c) 27 healthy mechanical lumbar pain subjects. Physical examinations of the SIJs were assessed as positive or negative in each SIJ and were used as the gold standard...
September 13, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28839380/optimization-of-polysaccharide-ultrasonic-extraction-conditions-using-purple-sweet-potato-tubers-based-on-free-radical-scavenging-and-glycosylation-inhibitory-bioactivities
#4
Haihua Guo, Fansheng Kong, Chunyan Yan
BACKGROUND: The purple sweet potato, Ipomoea batatas, belongs to the family Convolvulaceae. It is one of the most widely consumed tubers in Asia and is found in many dishes. Many people with diabetes eat purple sweet potato tubers to help reduce blood glucose in China. OBJECTIVE: To predict the ultrasonic conditions for getting the optimal in vitro antioxidant and antiglycated activity of ultrasonic extracted polysaccharides from purple sweet potato (I. batatas) tubers, the artificial neural network (ANN) regression models was used in this study...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28774603/dbp-formation-from-degradation-of-deet-and-ibuprofen-by-uv-chlorine-process-and-subsequent-post-chlorination
#5
Ehsan Aghdam, Yingying Xiang, Jianliang Sun, Chii Shang, Xin Yang, Jingyun Fang
The formation of disinfection by-products (DBPs) from the degradation of N,N-diethyl-3-methyl benzoyl amide (DEET) and ibuprofen (IBP) by the ultraviolet irradiation (UV)/chlorine process and subsequent post-chlorination was investigated and compared with the UV/H2O2 process. The pseudo first-order rate constants of the degradation of DEET and IBP by the UV/chlorine process were 2 and 3.1 times higher than those by the UV/H2O2 process, respectively, under the tested conditions. This was due to the significant contributions of both reactive chlorine species (RCS) and hydroxyl radicals (HO) in the UV/chlorine process...
August 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28772434/supercritical-co%C3%A2-assisted-spray-drying-of-strawberry-like-gold-coated-magnetite-nanocomposites-in-chitosan-powders-for-inhalation
#6
Marta C Silva, Ana Sofia Silva, Javier Fernandez-Lodeiro, Teresa Casimiro, Carlos Lodeiro, Ana Aguiar-Ricardo
Lung cancer is one of the leading causes of death worldwide. Therefore, it is of extreme importance to develop new systems that can deliver anticancer drugs into the site of action when initiating a treatment. Recently, the use of nanotechnology and particle engineering has enabled the development of new drug delivery platforms for pulmonary delivery. In this work, POXylated strawberry-like gold-coated magnetite nanocomposites and ibuprofen (IBP) were encapsulated into a chitosan matrix using Supercritical Assisted Spray Drying (SASD)...
January 18, 2017: Materials
https://www.readbyqxmd.com/read/28764332/pharmaceutical-removal-from-water-effluents-by-adsorption-on-activated-carbons-a-monte-carlo-simulation-study
#7
Daniel Bahamon, Lourdes F Vega
Adsorption on activated carbons of five pharmaceutical molecules (ibuprofen, diclofenac, naproxen, paracetamol, and amoxicillin) in aqueous mixtures has been investigated by molecular simulations using the Grand Canonical Monte Carlo (GCMC) method. A virtual nanoporous carbon model based on polyaromatic units with defects and polar-oxygenated sites was used for this purpose. The simulation results show excellent agreement with available experimental data. The adsorption capacities of the carbons for the five drugs were quite different and were linked, essentially, to their molecular dimensions and atom affinities...
August 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28752080/to-eat-and-to-be-eaten-mutual-metabolic-adaptations-of-immune-cells-and-intracellular-bacterial-pathogens-upon-infection
#8
REVIEW
Wolfgang Eisenreich, Thomas Rudel, Jürgen Heesemann, Werner Goebel
Intracellular bacterial pathogens (IBPs) invade and replicate in different cell types including immune cells, in particular of the innate immune system (IIS) during infection in the acute phase. However, immune cells primarily function as essential players in the highly effective and integrated host defense systems comprising the IIS and the adaptive immune system (AIS), which cooperatively protect the host against invading microbes including IBPs. As countermeasures, the bacterial pathogens (and in particular the IBPs) have developed strategies to evade or reprogram the IIS at various steps...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28748847/clinical-features-of-isolated-bulbar-palsy-of-amyotrophic-lateral-sclerosis-in-chinese-population
#9
Hua-Gang Zhang, Lu Chen, Lu Tang, Nan Zhang, Dong-Sheng Fan
BACKGROUND: Progressive bulbar palsy (PBP) is a classic phenotype of bulbar onset amyotrophic lateral sclerosis (ALS) with more rapid progression and worse prognosis. However, as an often under-understood variant of ALS, isolated bulbar palsy (IBP) appears to progress more slowly and has a relatively benign prognosis. This study aimed to investigate the natural course and clinical features of IBP in Chinese population and to compare them with those of PBP. METHODS: The clinical data of patients with bulbar onset ALS were collected from January 2009 to December 2013...
August 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28732956/sonocatalytic-removal-of-ibuprofen-and-sulfamethoxazole-in-the-presence-of-different-fly-ash-sources
#10
Yasir A J Al-Hamadani, Chang Min Park, Lateef N Assi, Kyoung Hoon Chu, Shamia Hoque, Min Jang, Yeomin Yoon, Paul Ziehl
We examined the feasibility of using two types of fly ash (an industrial waste from thermal power plants) as a low-cost catalyst to enhance the ultrasonic (US) degradation of ibuprofen (IBP) and sulfamethoxazole (SMX). Two fly ashes, Belews Creek fly ash (BFA), from a power station in North Carolina, and Wateree Station fly ash (WFA), from a power station in South Carolina, were used. The results showed that >99% removal of IBP and SMX was achieved within 30 and 60min of sonication, respectively, at 580kHz and pH 3...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28723210/bipolar-electrodes-with-100-current-efficiency-for-sensors
#11
Xiaowei Zhang, Qingfeng Zhai, Huanhuan Xing, Jing Li, Erkang Wang
A bipolar electrode (BPE) is an electron conductor that is embedded in the electrolyte solution without the direct connection with the external power source (driving electrode). When the sufficient voltage was provided, the two poles of BPE promote different oxidation and reduction reactions. During the past few years, BPEs with wireless feature and easy integration showed great promise in the various fields including asymmetric modification/synthesis, motion control, targets enrichment/separation, and chemical sensing/biosensing combined with the quantitative relationship between two poles of BPE...
March 24, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28719845/the-effects-of-ibuprofen-on-activated-sludge-shift-in-bacterial-community-structure-and-resistance-to-ciprofloxacin
#12
Madars Davids, Dita Gudra, Ilze Radovica-Spalvina, Davids Fridmanis, Vadims Bartkevics, Olga Muter
Ibuprofen (IBP) is ranked at the 4th place among 57 pharmaceutical compounds according to the number of citations in prioritization documents. The response of microbial community of activated sludge to IBP was studied at the concentrations of 50-5000mg/L. Batch incubation was performed in an OxiTop® device for 21days. The reduction of biological oxygen demand depended on the IBP concentration and varied in the range from 321 to 107mg O2/L. Massive DNA sequencing analysis of the activated sludge revealed that Proteobacteria became more dominant when grown in the presence of IBP...
June 28, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28693033/axial-involvement-according-to-asas-criteria-in-an-observational-psoriatic-arthritis-cohort
#13
Pedro David Carvalho, Florencia Savy, Carmen Moragues, Xavier Juanola, Jesus Rodriguez-Moreno
The definition of axial involvement in psoriatic arthritis (PsA) is still under debate. Currently, the axial spondyloarthritis (SpA) criteria defined by Assessment of Spondyloarthritis International Society (ASAS) may be the most adequate.(1) The aims of present study were to assess axial involvement according to ASAS criteria in an observational PsA cohort and define the clinical characteristics more associated with this kind of involvement. Our study included consecutive patients who had a visit in a tertiary Rheumatology centre...
April 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28692649/individual-ball-possession-in-soccer
#14
Daniel Link, Martin Hoernig
This paper describes models for detecting individual and team ball possession in soccer based on position data. The types of ball possession are classified as Individual Ball Possession (IBC), Individual Ball Action (IBA), Individual Ball Control (IBC), Team Ball Possession (TBP), Team Ball Control (TBC) und Team Playmaking (TPM) according to different starting points and endpoints and the type of ball control involved. The machine learning approach used is able to determine how long the ball spends in the sphere of influence of a player based on the distance between the players and the ball together with their direction of motion, speed and the acceleration of the ball...
2017: PloS One
https://www.readbyqxmd.com/read/28678269/diruthenium-ii-iii-metallodrugs-of-ibuprofen-and-naproxen-encapsulated-in-intravenously-injectable-polymer-lipid-nanoparticles-exhibit-enhanced-activity-against-breast-and-prostate-cancer-cells
#15
Samara R Alves Rico, Azhar Z Abbasi, Geise Ribeiro, Taksim Ahmed, Xiao Yu Wu, Denise de Oliveira Silva
A unique class of diruthenium(ii,iii) metallodrugs containing non-steroidal anti-inflammatory drug (NSAID), Ru2(NSAID), have been reported to show anticancer activity in glioma models in vitro and in vivo. This work reports the encapsulation of the lead metallodrug of ibuprofen (HIbp), [Ru2(Ibp)4Cl] or RuIbp, and also of the new analogue of naproxen (HNpx), [Ru2(Npx)4Cl] or RuNpx, in novel intravenously (i.v.) injectable solid polymer-lipid nanoparticles (SPLNs). A rationally selected composition of lipids/polymers rendered nearly spherical Ru2(NSAID)-SPLNs with a mean size of 120 nm and zeta potential of about -20 mV...
August 3, 2017: Nanoscale
https://www.readbyqxmd.com/read/28659534/photo-degradation-ibuprofen-by-uv-h2o2-process-response-surface-analysis-and-degradation-mechanism
#16
Mingguo Peng, Huajie Li, Xu Kang, Erdeng Du, Dongdong Li
The removal of ibuprofen (IBP) in aqueous solution using UV/H2O2 process was evaluated. The response surface methodology (RSM) and Box-Behnken design were employed to investigate the effects of process parameters on IBP removal, including the initial IBP concentration, H2O2 dosage, UV light intensity, and initial pH value of solution. The RSM model developed herein fits well with the experiments, and provides a good insight into the OH radical irritated degradation mechanisms and kinetics. High resolution accurate mass spectrometry coupled with liquid chromatography was used to identify the degradation intermediates...
June 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28657626/from-ice-binding-proteins-to-bio-inspired-antifreeze-materials
#17
REVIEW
I K Voets
Ice-binding proteins (IBP) facilitate survival under extreme conditions in diverse life forms. IBPs in polar fishes block further growth of internalized environmental ice and inhibit ice recrystallization of accumulated internal crystals. Algae use IBPs to structure ice, while ice adhesion is critical for the Antarctic bacterium Marinomonas primoryensis. Successful translation of this natural cryoprotective ability into man-made materials holds great promise but is still in its infancy. This review covers recent advances in the field of ice-binding proteins and their synthetic analogues, highlighting fundamental insights into IBP functioning as a foundation for the knowledge-based development of cheap, bio-inspired mimics through scalable production routes...
July 19, 2017: Soft Matter
https://www.readbyqxmd.com/read/28654723/comparison-of-two-species-specific-oscillometric-blood-pressure-monitors-with-direct-blood-pressure-measurement-in-anesthetized-cats
#18
Sofia A Cerejo, Francisco J Teixeira-Neto, Natache A Garofalo, Jéssica C Rodrigues, Nathalia Celeita-Rodríguez, Angie P Lagos-Carvajal
OBJECTIVE: To compare the performance of 2 species-specific oscillometric blood pressure (OBP) monitors (petMAPclassic and petMAPgraphic ) with direct blood pressure measurement in anesthetized cats. DESIGN: Prospective, experimental study. SETTING: Veterinary teaching hospital. ANIMALS: Eight adult cats (3.2-5.5 kg). INTERVENTIONS: During isoflurane anesthesia, OBP cuffs were placed on the thoracic limb and on the base of the tail while invasive blood pressure (IBP) was recorded from a dorsal pedal artery...
July 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28653294/electrospun-plga-nanofiber-scaffolds-release-ibuprofen-faster-and-degrade-slower-after-in-vivo-implantation
#19
Corinne N Riggin, Feini Qu, Dong Hwa Kim, Julianne Huegel, David R Steinberg, Andrew F Kuntz, Louis J Soslowsky, Robert L Mauck, Joseph Bernstein
While delayed delivery of non-steroidal anti-inflammatory drugs (NSAIDs) has been associated with improved tendon healing, early delivery has been associated with impaired healing. Therefore, NSAID use is appropriate only if the dose, timing, and mode of delivery relieves pain but does not impede tissue repair. Because delivery parameters can be controlled using drug-eluting nanofibrous scaffolds, our objective was to develop a scaffold for local controlled release of ibuprofen (IBP), and characterize the release profile and degradation both in vitro and in vivo...
June 26, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28640897/impact-of-selected-non-steroidal-anti-inflammatory-pharmaceuticals-on-microbial-community-assembly-and-activity-in-sequencing-batch-reactors
#20
Cong Jiang, Jinju Geng, Haidong Hu, Haijun Ma, Xingsheng Gao, Hongqiang Ren
This study covers three widely detected non-steroidal anti-inflammatory pharmaceuticals (NSAIDs), diclofenac (DCF), ibuprofen (IBP) and naproxen (NPX), as NSAIDs pollutants. The objective is to evaluate the impact of NSAIDs at their environmental concentrations on microbial community assembly and activity. The exposure experiments were conducted under three conditions (5 μg L-1 DCF, 5 μg L-1 DCF+5 μg L-1 IBP and 5 μg L-1 DCF+5 μg L-1 IBP+ 5 μg L-1 NPX) in sequencing batch reactors (SBRs) for 130 days...
2017: PloS One
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