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https://www.readbyqxmd.com/read/29735675/polypentagonal-ice-like-water-networks-emerge-solely-in-an-activity-improved-variant-of-ice-binding-protein
#1
Sheikh Mahatabuddin, Daichi Fukami, Tatsuya Arai, Yoshiyuki Nishimiya, Rumi Shimizu, Chie Shibazaki, Hidemasa Kondo, Motoyasu Adachi, Sakae Tsuda
Polypentagonal water networks were recently observed in a protein capable of binding to ice crystals, or ice-binding protein (IBP). To examine such water networks and clarify their role in ice-binding, we determined X-ray crystal structures of a 65-residue defective isoform of a Zoarcidae -derived IBP (wild type, WT) and its five single mutants (A20L, A20G, A20T, A20V, and A20I). Polypentagonal water networks composed of ∼50 semiclathrate waters were observed solely on the strongest A20I mutant, which appeared to include a tetrahedral water cluster exhibiting a perfect position match to the [Formula: see text] first prism plane of a single ice crystal...
May 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29729656/innovation-based-practice-ibp-versus-evidence-based-practice-ebp-a-new-perspective-that-assesses-and-differentiates-evidence-and-innovation
#2
EDITORIAL
Michael H Ackerman, Tim Porter-O'Grady, Kathy Malloch, Bernadette Mazurek Melnyk
No abstract text is available yet for this article.
May 5, 2018: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/29701426/is-invasive-pressure-monitoring-more-reliable-than-non-invasive-in-patients-with-cardiovascular-pathology-a-case-report
#3
Andreia Fernandes, Luísa Coimbra, Inês Delgado, José Carvalho, Carla Bentes
INTRODUCTION: Patients undergoing carotid endarterectomy (CEA) require strict arterial blood pressure (BP) control to maintain adequate cerebral perfusion. Invasive blood pressure (IBP) is the gold standard, however artifacts may lead to erroneous readings. METHODS: We report a case of CEA using IBP monitoring. RESULTS: A 64-year-old man, American Society Anaesthesiology (ASA) physical status 3 (diffuse atheromathosis, dyslipidemia and non-medicated hypertension), was presented for an elective right CEA...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29699730/defining-degree-of-aortic-occlusion-for-partial-reboa-a-computed-tomography-study-on-large-animals
#4
Viktor A Reva, Yosuke Matsumura, Igor M Samokhvalov, Alexander A Pochtarnik, Igor S Zheleznyak, Ekaterina M Mikhailovskaya, Jonathan J Morrison
INTRODUCTION: Partial resuscitative endovascular balloon occlusion of the aorta (P-REBOA) is a modified REBOA technique designed to help ameliorate ischemia-reperfusion injury. The balloon is partially deflated, allowing a proportion of aortic flow distal to the balloon. The aim of this study is to use an ovine model of haemorrhagic shock to correlate the degree of occlusion to several hemodynamic indices. MATERIALS AND METHODS: Six sheep weighing 35-46 kg underwent a controlled venous haemorrhage inside a CT scanner until the systolic arterial pressure (AP) dropped to <90 mmHg...
April 20, 2018: Injury
https://www.readbyqxmd.com/read/29663159/evaluation-of-the-effect-of-polyphenol-of-escin-compared-with-ibuprofen-and-dexamethasone-in-synoviocyte-model-for-osteoarthritis-an-in-vitro-study
#5
Hossein Maghsoudi, Jamal Hallajzadeh, Mozhghan Rezaeipour
Osteoarthritis (OA) is a chronic degenerative joint disease with inflammatory component. It is associated with progressive histological alterations and disabling symptoms. Today, drugs such as glucocorticoids (GCs) and nonsteroidal anti-inflammatory drugs (NSIADs) are commonly employed for treatment of osteoarthritis, but have serious and life-threatening side effects. The aim of the current study is to evaluate the effects of escin on cyclooxygenase-2 (COX-2, isoform), inducible nitric oxide synthase (iNOS), interleukin-1β (IL-1β), interleukin-18 (IL-18), tumor necrosis factor-alpha (TNF-α), and nitric oxide (NO) (1), as well as prostaglandin E2 (PGE2) on inflammatory cells, similar osteoarthritis in synoviocytes, and monocytes/macrophages, and to compare it with dexamethasone (DEX) and ibuprofen (IBP)...
April 16, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29625916/agreement-between-invasive-blood-pressures-measured-in-three-peripheral-arteries-in-anaesthetized-horses-under-clinical-conditions
#6
Keely A T Wilson, Anthea L Raisis, Eleanor A Drynan, Guy D Lester, Giselle L Hosgood
OBJECTIVE: To determine agreement between invasive blood pressures measured in three peripheral arteries in anaesthetized horses undergoing elective surgery. STUDY DESIGN: Prospective balanced incomplete block design. ANIMALS: A total of 18 client-owned horses. METHODS: Invasive blood pressure (IBP) was measured simultaneously in one of the following three combinations: 1) transverse facial and facial artery; 2) transverse facial and metatarsal artery; and 3) facial and metatarsal artery...
January 17, 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29616123/overexpression-and-clinical-significance-of-ibp-in-epithelial-ovarian-carcinoma
#7
Yingjuan Xu, Yangming Hou, Tianbo Liu, Ge Lou
Interferon regulatory factor-4 binding protein (IBP) is as a type of ρ GTPase suggested to serve an important role in tumor occurrence and development through the effects of cytoskeletal remodeling, and cell conduction mechanism. IBP is widely expressed in the immune system and expressed in several types of tumors. However, its expression and prognostic value in epithelial ovarian carcinoma (EOC) remain unclear. The present study aimed to investigate the expression of IBP in EOC, and its effect on clinicopathological variables and prognosis...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29558859/accuracy-of-an-oscillometric-blood-pressure-monitor-in-anesthetized-pigs
#8
Rachel Reed, Michele Barletta, Janet Grimes, Jennifer Mumaw, Hea Jin Park, Steeve Giguère, Michael Azain, Xi Fang, Jane Quandt
The purpose of this study is to evaluate the accuracy of an oscillometric blood pressure monitor in anesthetized pigs. Invasive blood pressure (IBP) and noninvasive blood pressure (NIBP) measurements were taken using a DRE Waveline Pro multiparameter monitor at four different time points in 17 pigs undergoing injectable anesthesia. NIBP measurements were taken on both the thoracic and pelvic limbs. Bland Altman analysis was used to assess agreement between methods and a linear mixed-effects model was used to evaluate the effect of cuff position and blood pressure on bias...
January 1, 2018: Laboratory Animals
https://www.readbyqxmd.com/read/29554753/effects-of-dissolved-organic-matter-and-nitrification-on-biodegradation-of-pharmaceuticals-in-aerobic-enrichment-cultures
#9
Yujie He, Alette A M Langenhoff, Rob N J Comans, Nora B Sutton, Huub H M Rijnaarts
Natural dissolved organic matter (DOM) and nitrification can play an important role in biodegradation of pharmaceutically active compounds (PhACs) in aerobic zones of constructed wetlands (CWs). This study used an enrichment culture originating from CW sediment to study the effect of DOM and nitrification on aerobic biodegradation of seven PhACs. The enriched culture degraded caffeine (CAF), metoprolol (MET), naproxen (NAP), and ibuprofen (IBP) with a consistent biodegradability order of CAF>MET>NAP>IBP...
March 2, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29554239/adpredict-adp-ribosylation-site-prediction-based-on-physicochemical-and-structural-descriptors
#10
Matteo Lo Monte, Candida Manelfi, Marica Gemei, Daniela Corda, Andrea Rosario Beccari
Motivation: ADP-ribosylation is a post-translational modification implicated in several crucial cellular processes, ranging from regulation of DNA repair and chromatin structure to cell metabolism and stress responses. To date, a complete understanding of ADP-ribosylation targets and their modification sites in different tissues and disease states is still lacking. Identification of ADP-ribosylation sites is required to discern the molecular mechanisms regulated by this modification. This motivated us to develop a computational tool for the prediction of ADP-ribosylated sites...
March 15, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29552426/physiological-recording-in-the-mri-environment-prime-mri-compatible-hemodynamic-recording-system
#11
John W Kakareka, Anthony Z Faranesh, Randall H Pursley, Adrienne Campbell-Washburn, Daniel A Herzka, Toby Rogers, Josh Kanter, Kanishka Ratnayaka, Robert J Lederman, Thomas J Pohida
Hemodynamic recording during interventional cardiovascular procedures is essential for procedural guidance, monitoring patient status, and collection of diagnostic information. Recent advances have made interventions guided by magnetic resonance imaging (MRI) possible and attractive in certain clinical scenarios. However, in the MRI environment, electromagnetic interference (EMI) can cause severe distortions and artifacts in acquired hemodynamic waveforms. The primary aim of this paper was to develop and validate a system to minimize EMI on electrocardiogram (ECG) and invasive blood pressure (IBP) signals...
2018: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/29533528/structure-of-a-bacterial-ice-binding-protein-with-two-faces-of-interaction-with-ice
#12
Marco Mangiagalli, Guy Sarusi, Aleksei Kaleda, Maya Bar Dolev, Valentina Nardone, Vittoria Federica Vena, Ido Braslavsky, Marina Lotti, Marco Nardini
Ice-binding proteins (IBPs) contribute to the survival of many living beings at subzero temperature by controlling the formation and growth of ice crystals. This work investigates the structural basis of the ice-binding properties of EfcIBP, obtained from Antarctic bacteria. EfcIBP is endowed with a unique combination of thermal hysteresis and ice recrystallization inhibition activity. The three-dimensional structure, solved at 0.84 Å resolution, shows that EfcIBP belongs to the IBP-1 fold family, and is organized in a right-handed β-solenoid with a triangular cross-section that forms three protein surfaces, named A, B, and C faces...
May 2018: FEBS Journal
https://www.readbyqxmd.com/read/29498209/an-ice-binding-and-tandem-beta-sandwich-domain-containing-protein-in-shewanella-frigidimarina-is-a-potential-new-type-of-ice-adhesin
#13
Tyler D R Vance, Laurie A Graham, Peter L Davies
Out of the dozen different ice-binding protein (IBP) structures known, the DUF3494 domain is the most widespread, having been passed many times between prokaryotic and eukaryotic microorganisms by horizontal gene transfer. This ~25-kDa β-solenoid domain with an adjacent parallel α-helix is most commonly associated with an N-terminal secretory signal peptide. However, examples of the DUF3494 domain preceded by tandem Bacterial Immunoglobulin-like (BIg) domains are sometimes found, though uncharacterized. Here, we present one such protein (SfIBP_1) from the Antarctic bacterium Shewanella frigidimarina...
April 2018: FEBS Journal
https://www.readbyqxmd.com/read/29483597/regulation-of-age-associated-b-cells-by-irf5-in-systemic-autoimmunity
#14
Michela Manni, Sanjay Gupta, Edd Ricker, Yurii Chinenov, Sung Ho Park, Man Shi, Tania Pannellini, Rolf Jessberger, Lionel B Ivashkiv, Alessandra B Pernis
Age-associated B cells (ABCs) are a subset of B cells dependent on the transcription factor T-bet that accumulate prematurely in autoimmune settings. The pathways that regulate ABCs in autoimmunity are largely unknown. SWAP-70 and DEF6 (also known as IBP or SLAT) are the only two members of the SWEF family, a unique family of Rho GTPase-regulatory proteins that control both cytoskeletal dynamics and the activity of the transcription factor IRF4. Notably, DEF6 is a newly identified human risk variant for systemic lupus erythematosus...
April 2018: Nature Immunology
https://www.readbyqxmd.com/read/29471593/clinical-evolution-of-patients-with-new-onset-inflammatory-back-pain-a-population-based-cohort-study
#15
Runsheng Wang, Cynthia S Crowson, Kerry Wright, Michael M Ward
OBJECTIVE: Inflammatory back pain (IBP) is often an early manifestation of spondyloarthritis (SpA), but the prognosis of patients with incident IBP is unknown. We investigated the long-term outcomes of patients with IBP, and predictors of progression to SpA, in a retrospective longitudinal study of a population-based cohort. METHODS: We used the Rochester Epidemiology Project, a longstanding population-based study of residents of Olmsted County, Minnesota, USA, to identify patients aged 16 to 35 with clinical visits for back pain from 1999 to 2003...
February 22, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29439257/assessing-extracellular-volume-in-hemodialysis-patients-using-intradialytic-blood-pressure-slopes
#16
Hao Liu, Rong Lu, Shani Shastri, Mark Sonderman, Peter Noel Van Buren
BACKGROUND/AIMS: Extracellular volume (ECV) overload is a mortality risk factor in hemodialysis patients, but no standard approach exists to objectively assess this clinically. We aimed to quantify relationships between slopes of repeated intradialytic blood pressure (BP) measurements and ECV. METHODS: In a cross-sectional study of 71 hemodialysis patients, we calculated BP slopes from all intradialytic measurements using Gaussian regression. We measured extracellular and total body water (TBW) with bioimpedance spectroscopy...
February 13, 2018: Nephron
https://www.readbyqxmd.com/read/29414893/spatio-temporal-super-resolution-reconstruction-of-remote-sensing-images-based-on-adaptive-multi-scale-detail-enhancement
#17
Hong Zhu, Xinming Tang, Junfeng Xie, Weidong Song, Fan Mo, Xiaoming Gao
There are many problems in existing reconstruction-based super-resolution algorithms, such as the lack of texture-feature representation and of high-frequency details. Multi-scale detail enhancement can produce more texture information and high-frequency information. Therefore, super-resolution reconstruction of remote-sensing images based on adaptive multi-scale detail enhancement (AMDE-SR) is proposed in this paper. First, the information entropy of each remote-sensing image is calculated, and the image with the maximum entropy value is regarded as the reference image...
February 7, 2018: Sensors
https://www.readbyqxmd.com/read/29384902/standard-versus-extralevator-abdominoperineal-excision-and-oncologic-outcomes-for-patients-with-distal-rectal-cancer-a-meta-analysis
#18
COMPARATIVE STUDY
Yunfeng Zhang, Duo Wang, Lizhe Zhu, Bin Wang, Xiaoxia Ma, Bohui Shi, Yu Yan, Can Zhou
BACKGROUND: The role of extralevator abdominoperineal excision (ELAPE) for distal rectal cancer remains controversial, and the procedure is not widely accepted or practiced. METHODS: An electronic search of Medline, EMBASE, Web of Science, and similar databases for articles in English was performed from the inception of the study until October 31, 2017. Two reviewers extracted information and independently assessed the quality of included studies by the methodological index for nonrandomized studies, then data were analyzed with Review Manager 5...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29369954/short-term-training-cessation-as-a-method-of-tapering-to-improve-maximal-strength
#19
Hayden J Pritchard, Matthew J Barnes, Robin J C Stewart, Justin W L Keogh, Michael R McGuigan
Pritchard, HJ, Barnes, MJ, Stewart, RJC, Keogh, JWL, and McGuigan, MR. Short-term training cessation as a method of tapering to improve maximal strength. J Strength Cond Res 32(2): 458-465, 2018-The aim of this study was to determine the effects of 2 different durations of training cessation on upper- and lower-body maximal strength performance and to investigate the mechanisms underlying performance changes following short-term training cessation. Eight resistance trained males (23.8 ± 5.4 years, 79.6 ± 10...
February 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29349901/inflammatory-back-pain-and-associated-disease-conditions-among-patients-with-chronic-low-back-pain-in-bangladesh
#20
Sabrina Yesmin, Syed Jamil Abdal, Aminur Rahman, Md Nazrul Islam, Alamgir Mustak Ahammad, Shamim Ahmed, Md Abu Shahin, Minhaj Rahim Chowdhury, Syed Atiqul Haq
AIM: Inflammatory back pain (IBP) is the earliest symptom of axial and other forms of spondyloarthritis (SpA). However, there are no published data on prevalence of IBP among patients suffering from chronic low back pain (CLBP) in Bangladesh. In this study, we estimated the prevalence of IBP and the subtypes of SpA in a tertiary hospital in Bangladesh. METHODS: This 1 year cross-sectional study was conducted among 240 CLBP patients in a rheumatology outpatient clinic...
January 18, 2018: International Journal of Rheumatic Diseases
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