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https://www.readbyqxmd.com/read/28101901/cyto-genotoxicity-and-oxidative-stress-in-common-carp-cyprinus-carpio-exposed-to-a-mixture-of-ibuprofen-and-diclofenac
#1
Hariz Islas-Flores, Leobardo Manuel Gómez-Oliván, Marcela Galar-Martínez, Esmeralda Michelle Sánchez-Ocampo, Nely SanJuan-Reyes, Mariana Ortíz-Reynoso, Octavio Dublán-García
Thirty million people worldwide consume each day nonsteroidal anti-inflammatory drugs (NSAIDs), a heterogeneous group of pharmaceuticals used for its analgesic, antipyretic, and anti-inflammatory properties. Recent studies report high NSAID concentrations in wastewater treatment plant effluents, in surface, ground, and drinking water, and in sediments. NSAIDs are also known to induce toxicity on aquatic organisms. However, toxicity in natural ecosystems is not usually the result of exposure to a single substance but to a mixture of toxic agents, yet only a few studies have evaluated the toxicity of mixtures...
January 19, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28063066/high-prevalence-of-undiagnosed-axial-spondyloarthritis-in-patients-with-chronic-low-back-pain-consulting-non-rheumatologist-specialists-in-belgium-suspect-study
#2
Laure Tant, Nadine Delmotte, Maria Van den Enden, Valerie Gangji, Herman Mielants
INTRODUCTION: Diagnosis of axial spondyloarthritis (SpA) can be delayed for several years mainly because of low awareness of axial SpA among non-rheumatologists who are the first interlocutors of potential SpA patients. One strategy to decrease the delay between appearance of first symptoms and diagnosis of axial SpA and to allow early management of the disease is to provide the non-rheumatologists with tools to identify patients requiring prompt referral to rheumatologists. This study was designed to evaluate in a real-world setting whether screening patients with chronic low back pain who consult physical medicine and rehabilitation (PMR) physicians, orthopedists, and ophthalmologists is useful in detecting axial SpA...
January 6, 2017: Rheumatology and Therapy
https://www.readbyqxmd.com/read/28038742/ibuprofen-loaded-pva-chitosan-membranes-a-highly-efficient-strategy-towards-an-improved-skin-wound-healing
#3
Patrícia I Morgado, Sónia P Miguel, Ilídio J Correia, Ana Aguiar-Ricardo
During wound healing, an early inflammation can cause an increase of the wound size and the healing process can be considerably belated if a disproportionate inflammatory response occurs. (S)-ibuprofen (IBP), a non-steroidal anti-inflammatory agent, has been used for muscle healing and to treat venous leg ulcers, but its effect in skin wound healing has not been thoroughly studied thus far. Herein, IBP-β-cyclodextrins carriers were designed to customise the release profile of IBP from poly(vinyl alcohol)/chitosan (PVA/CS) dressings in order to promote a faster skin regeneration...
March 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28035668/ice-and-anti-nucleating-activities-of-an-ice-binding-protein-from-the-annual-grass-brachypodium-distachyon
#4
Melissa Bredow, Heather E Tomalty, Lindsay Smith, Virginia K Walker
Plants exposed to sub-zero temperatures face unique challenges that threaten their survival. The growth of ice crystals in the extracellular space can cause cellular dehydration, plasma membrane rupture, and eventual cell death. Additionally, some pathogenic bacteria cause tissue damage by initiating ice crystal growth at high sub-zero temperatures through the use of ice nucleating proteins (INPs), presumably to access nutrients from lysed cells. An annual species of brome grass, Brachypodium distachyon (Bd), produces an ice-binding protein (IBP) that shapes ice with a modest depression of the freezing point (~0...
December 30, 2016: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28012225/drivers-of-genetic-differentiation-in-a-generalist-insect-pollinated-herb-across-spatial-scales
#5
A J Muñoz-Pajares, C García, M Abdelaziz, J Bosch, F Perfectti, J M Gómez
The isolation by distance model (IBD) predicts that genetic differentiation among populations increases with geographic distance. Yet, empirical studies show that a variety of ecological, topographic, and historical factors may override the effect of geographic distance on genetic variation. This may particularly apply to species with narrow but highly heterogeneous distribution ranges, such as those occurring along elevational gradients. Using nine SSR markers, we study the genetic differentiation of the montane pollination-generalist herb, Erysimum mediohispanicum...
December 24, 2016: Molecular Ecology
https://www.readbyqxmd.com/read/27987298/the-role-of-civil-society-in-strengthening-intercultural-maternal-health-care-in-local-health-facilities-puno-peru
#6
Jeannie Samuel
BACKGROUND AND OBJECTIVE: Peru's Ministry of Health has made efforts to increase the cultural inclusiveness of maternal health services. In 2005, the Ministry adopted an intercultural birthing policy (IBP) that authorizes and encourages the use of culturally acceptable birthing practices in government-run health facilities. However, studies suggest that indigenous women may receive inconsistent benefits from these kinds of policies. This article examines whether a grassroots accountability initiative based on citizen monitoring of local health facilities by indigenous women can help to promote the objectives of the IBP and improve intercultural maternal health care...
2016: Global Health Action
https://www.readbyqxmd.com/read/27973620/a-genome-wide-snp-linkage-analysis-suggests-a-susceptibility-locus-on-6p21-for-ankylosing-spondylitis-and-inflammatory-back-pain-trait
#7
Yanli Zhang, Zetao Liao, Qiujing Wei, Yunfeng Pan, Xinwei Wang, Shuangyan Cao, Zishi Guo, Yuqiong Wu, Ju Rong, Ou Jin, Manlong Xu, Zhiming Lin, Jieruo Gu
OBJECTIVES: To screen susceptibility loci for ankylosing spondylitis (AS) using an affected-only linkage analysis based on high-density single nucleotide polymorphisms (SNPs) in a genome-wide manner. PATIENTS AND METHODS: AS patients from ten families with Cantonese origin of China were enrolled in the study. Blood samples were genotyped using genomic DNA derived from peripheral blood leukocytes by Illumina HumanHap 610-Quad SNP Chip. Genotype data were generated using the Illumina BeadStudio 3...
2016: PloS One
https://www.readbyqxmd.com/read/27969016/ineffective-breathing-pattern-in-cardiac-postoperative-patients-diagnostic-accuracy-study
#8
Vanessa Emille Carvalho de Sousa, Lívia Maia Pascoal, Ranielly Vidal do Nascimento, Talita Ferreira Oliveira de Matos, Beatriz Amorim Beltrão, Viviane Martins da Silva, Marcos Venícios de Oliveira Lopes
PURPOSE: The aim of this study was to analyze the accuracy of the defining characteristics of ineffective breathing pattern (IBP) in postoperative cardiac patients. METHODS: A diagnostic accuracy study was performed with 98 patients. Measures of sensitivity, specificity, predictive values, likelihood ratios, diagnostic odds ratio, and area under the ROC curve were calculated. RESULTS: IBP was present in 23.5% of the patients. Alterations in depth of breathing (sensitivity 96%, negative likelihood ratio 0...
November 2016: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/27959937/knockdown-of-ice-binding-proteins-in-brachypodium-distachyon-demonstrates-their-role-in-freeze-protection
#9
Melissa Bredow, Barbara Vanderbeld, Virginia K Walker
Sub-zero temperatures pose a major threat to the survival of cold-climate perennials. Some of these freeze-tolerant plants produce ice-binding proteins (IBPs) that offer frost protection by restricting ice crystal growth and preventing expansion-induced lysis of the plasma membranes. Despite the extensive in vitro characterization of such proteins, the importance of IBPs in the freezing stress response has not been investigated. Using the freeze-tolerant grass and model crop, Brachypodium distachyon, we characterized putative IBPs (BdIRIs) and generated the first 'IBP-knockdowns'...
2016: PloS One
https://www.readbyqxmd.com/read/27932923/india-biodiversity-portal-an-integrated-interactive-and-participatory-biodiversity-informatics-platform
#10
Thomas Vattakaven, Rohit M George, Dhandapani Balasubramanian, Maxime Réjou-Méchain, Gowrappan Muthusankar, Brahmasamudra Ranganna Ramesh, R Prabhakar
BACKGROUND: This paper describes a growing biodiversity platform, launched in 2008, which organizes knowledge on the biodiversity of India. The main objective and originality of the India Biodiversity Portal (IBP) is to aggregate curated biodiversity data of different kinds (e.g. distribution maps, temporal distribution or life history) in an integrated platform where amateurs and experts can easily interact. NEW INFORMATION: Since its launch, the platform has seen an exceptional increase in both user activity and biodiversity data...
2016: Biodiversity Data Journal
https://www.readbyqxmd.com/read/27881992/molecular-mapping-and-qtl-for-expression-profiles-of-flavonoid-genes-in-brassica-napus
#11
Cunmin Qu, Huiyan Zhao, Fuyou Fu, Kai Zhang, Jianglian Yuan, Liezhao Liu, Rui Wang, Xinfu Xu, Kun Lu, Jia-Na Li
Flavonoids are secondary metabolites that are extensively distributed in the plant kingdom and contribute to seed coat color formation in rapeseed. To decipher the genetic networks underlying flavonoid biosynthesis in rapeseed, we constructed a high-density genetic linkage map with 1089 polymorphic loci (including 464 SSR loci, 97 RAPD loci, 451 SRAP loci, and 75 IBP loci) using recombinant inbred lines (RILs). The map consists of 19 linkage groups and covers 2775 cM of the B. napus genome with an average distance of 2...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27860412/cryo-protective-effect-of-an-ice-binding-protein-derived-from-antarctic-bacteria
#12
Marco Mangiagalli, Maya Bar-Dolev, Pietro Tedesco, Antonino Natalello, Aleksei Kaleda, Stefania Brocca, Donatella de Pascale, Sandra Pucciarelli, Cristina Miceli, Ido Bravslavsky, Marina Lotti
Cold environments are populated by organisms able to contravene deleterious effects of low temperature by diverse adaptive strategies, including the production of ice binding proteins (IBPs) that inhibit the growth of ice crystals inside and outside cells. We describe the properties of such a protein (EfcIBP) identified in the metagenome of an Antarctic biological consortium composed of the ciliate Euplotes focardii and psychrophilic non-cultured bacteria. Recombinant EfcIBP can resist freezing without any conformational damage and is moderately heat stable, with a midpoint temperature of 66...
November 17, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27835056/multispectroscopic-studies-on-the-interaction-of-a-copper-ii-complex-of-ibuprofen-drug-with-calf-thymus-dna
#13
Nahid Shahabadi, Farshad Shiri
The interaction of copper(II)-ibuprofenato complex with calf thymus DNA (ct-DNA) has been explored following, UV-visible spectrophotometry, fluorescence measurement, dynamic viscosity measurements, and circular dichroism spectroscopy. In spectrophotometric studies of ct-DNA it was found that [Cu(ibp)2]2 can form a complex with double-helical DNA. The association constant of [Cu(ibp)2]2 with DNA from UV-Vis study was found to be 6.19 × 10(4) L mol(-1). The values of Kf from fluorescence measurement clearly underscore the high affinity of [Cu(ibp)2]2 to DNA...
November 11, 2016: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/27809783/transcriptomic-data-from-panarthropods-shed-new-light-on-the-evolution-of-insulator-binding-proteins-in-insects-insect-insulator-proteins
#14
Thomas Pauli, Lucia Vedder, Daniel Dowling, Malte Petersen, Karen Meusemann, Alexander Donath, Ralph S Peters, Lars Podsiadlowski, Christoph Mayer, Shanlin Liu, Xin Zhou, Peter Heger, Thomas Wiehe, Lars Hering, Georg Mayer, Bernhard Misof, Oliver Niehuis
BACKGROUND: Body plan development in multi-cellular organisms is largely determined by homeotic genes. Expression of homeotic genes, in turn, is partially regulated by insulator binding proteins (IBPs). While only a few enhancer blocking IBPs have been identified in vertebrates, the common fruit fly Drosophila melanogaster harbors at least twelve different enhancer blocking IBPs. We screened recently compiled insect transcriptomes from the 1KITE project and genomic and transcriptomic data from public databases, aiming to trace the origin of IBPs in insects and other arthropods...
November 3, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27782870/factors-associated-with-the-decision-of-the-rheumatologist-to-order-sacroiliac-joints-magnetic-resonance-imaging-si-mri-or-hla-b27-testing-in-the-diagnostic-work-up-of-patients-with-spondyloarthritis-in-clinical-practice
#15
Wilson Bautista-Molano, Robert B M Landewé, Cesar Serna, Rafael Valle-Oñate, Désirée van der Heijde
OBJECTIVES: To evaluate the patients' characteristics associated with the clinical decision to request SI-MRI and/or HLA-B27 in patients with SpA in daily practice. METHODS: Patients referred to a rheumatology outpatient-clinic in a national referral-centre were selected. Patients with a clinical diagnosis of SpA according to the rheumatologist were included. SI-MRI and HLA-B27 was available for patients in whom the rheumatologists had ordered these tests. Characteristics associated with ordering SI-MRI or HLA-B27 were identified with univariable analyses...
October 26, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27773244/magnetic-pd-fe3o4-composite-nanostructure-as-recoverable-catalyst-for-sonoelectrohybrid-degradation-of-ibuprofen
#16
Binota Thokchom, Pengpeng Qiu, Mingcan Cui, Beomguk Park, Aniruddha B Pandit, Jeehyeong Khim
In the present research, the degradation of an emerging pharmaceutical micro-pollutant, Ibuprofen (IBP) by using Pd@Fe3O4 and a hybrid sono-electrolytical (US/EC) treatment system has been demonstrated for the first time. The magnetically separable nanocomposite, Pd@Fe3O4 catalyst was synthesized following co-precipitation method to enhance the efficiency of US/EC system. The synthesized catalyst showed a strong reusable property even after applying for five times and in all the five cases, 100% degradation of IBP was maintained...
January 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/27763509/electrochemical-selective-and-simultaneous-detection-of-diclofenac-and-ibuprofen-in-aqueous-solution-using-hkust-1-metal-organic-framework-carbon-nanofiber-composite-electrode
#17
Sorina Motoc, Florica Manea, Adriana Iacob, Alberto Martinez-Joaristi, Jorge Gascon, Aniela Pop, Joop Schoonman
In this study, the detection protocols for the individual, selective, and simultaneous determination of ibuprofen (IBP) and diclofenac (DCF) in aqueous solutions have been developed using HKUST-1 metal-organic framework-carbon nanofiber composite (HKUST-CNF) electrode. The morphological and electrical characterization of modified composite electrode prepared by film casting was studied by scanning electronic microscopy and four-point-probe methods. The electrochemical characterization of the electrode by cyclic voltammetry (CV) was considered the reference basis for the optimization of the operating conditions for chronoamperometry (CA) and multiple-pulsed amperometry (MPA)...
October 17, 2016: Sensors
https://www.readbyqxmd.com/read/27750164/ibuprofen-degradation-and-toxicity-evolution-during-fe-2-oxone-uv-process
#18
Han Gong, Wei Chu, So Hiu Lam, Angela Yu-Chen Lin
This study shows the degradation of ibuprofen in aqueous solution using oxone process mediated by Fe(2+) with UV irradiation (FOU). Fe(2+)/Oxone (FO), Fe(2+)/UV (FU), Oxone/UV (OU) processes were investigated separately to elucidate the role of different conditions in the processes. The effects of UV wavelength, the dosage of Fe(2+), the dosage of oxone, initial target compound concentration, solution pH and anions on the degradation efficiency were studied. In general the FOU is best performed among the processes...
January 2017: Chemosphere
https://www.readbyqxmd.com/read/27737617/improving-thermal-hysteresis-activity-of-antifreeze-protein-from-recombinant-pichia-pastoris-by-removal-of-n-glycosylation
#19
Eun Jae Kim, Jun Hyuck Lee, Sung Gu Lee, Se Jong Han
To survive in a sub-zero environment, polar organisms produce ice-binding proteins (IBPs). These IBPs prevent the formation of large intracellular ice crystals, which may be fatal to the organism. Recently, a recombinant FfIBP (an IBP from Flavobacterium frigoris PS1) was cloned and produced in Pichia pastoris using fed-batch fermentation with methanol feeding. In this study, we demonstrate that FfIBP produced by P. pastoris has a glycosylation site, which diminishes the thermal hysteresis (TH) activity of FfIBP...
October 13, 2016: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/27733482/high-throughput-hplc-ms-ms-method-for-quantification-of-ibuprofen-enantiomers-in-human-plasma-focus-on-investigation-of-metabolite-interference
#20
Natalija Nakov, Liljana Bogdanovska, Jelena Acevska, Jasmina Tonic-Ribarska, Rumenka Petkovska, Aneta Dimitrovska, Lilia Kasabova, Dobrin Svinarov
In this research, as a part of the development of fast and reliable HPLC-MS/MS method for quantification of ibuprofen (IBP) enantiomers in human plasma, the possibility of IBP acylglucoronide (IBP-Glu) back-conversion was assessed. This involved investigation of in source and in vitro back-conversion. The separation of IBP enantiomers, its metabolite and rac-IBP-d3 (internal standard), was achieved within 6 min using Chiracel OJ-RH chromatographic column (150 × 2.1 mm, 5 μm). The followed selected reaction monitoring transitions for IBP-Glu (m/z 381...
November 2016: Journal of Chromatographic Science
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