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https://www.readbyqxmd.com/read/28625724/the-binary-system-of-ibuprofen-nicotinamide-under-nanoscale-confinement-from-cocrystal-to-coamorphous-state
#1
Yanping Bi, Deli Xiao, Shuai Ren, Shuyan Bi, Jianzhu Wang, Fei Li
Coamorphous systems have gained success in stabilizing amorphous drugs and improving their solubility and dissolution. Here we proposed to confine a binary mixture of drug and coformer (CF) within nanopores to obtain a nano-confined coamorphous (NCA) system. For proving feasibility of this proposal, a poorly water-soluble drug (ibuprofen, IBP) and a frequently used pharmaceutical CF (nicotinamide, NIC) were loaded into nanopores of mesoporous silica microspheres (MSMs). The solid state of NCA system was characterized by differential scanning calorimetry, X-ray powder diffraction, infrared spectrum and solid state nuclear magnetic resonance...
June 15, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28585270/intra-and-interrater-reliability-of-the-chicago-classification-of-achalasia-subtypes-in-pediatric-high-resolution-esophageal-manometry-hrm-recordings
#2
M M J Singendonk, R Rosen, J Oors, N Rommel, M P van Wijk, M A Benninga, S Nurko, T I Omari
BACKGROUND: Subtyping achalasia by high-resolution manometry (HRM) is clinically relevant as response to therapy and prognosis have shown to vary accordingly. The aim of this study was to assess inter- and intrarater reliability of diagnosing achalasia and achalasia subtyping in children using the Chicago Classification (CC) V3.0. METHODS: Six observers analyzed 40 pediatric HRM recordings (22 achalasia and 18 non-achalasia) twice by using dedicated analysis software (ManoView 3...
June 6, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28575155/dynamic-bm-multispecies-dynamic-bodymap-database-from-temporal-rna-seq-data
#3
Ya Cui, Xiaowei Chen, Yiwei Niu, Dongpeng Wang, Huaxia Luo, Zhen Fan, Dan Wang, Wei Wu, Xueyi Teng, Shunmin He, Jianjun Luo, Runsheng Chen
Biological processes, especially developmental processes, are often dynamic. Previous BodyMap projects for human and mouse have provided researchers with portals to tissue-specific gene expression, but these efforts have not included dynamic gene expression patterns. Over the past few years, substantial progress in our understanding of the molecular mechanisms of protein-coding and long noncoding RNA (lncRNA) genes in development processes has been achieved through numerous time series RNA sequencing (RNA-seq) studies...
June 1, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28548588/injection-of-inactive-bordetella-pertussis-and-complete-freund-s-adjuvant-with-torpedo-californica-achr-increases-the-occurrence-of-experimental-autoimmune-myasthenia-gravis-in-c57bl-6-mice
#4
Takahiro Maruta, Minako Oshima, Dennis R Mosier, M Zouhair Atassi
An animal model of myasthenia gravis (MG), termed experimental autoimmune MG (EAMG), is an important tool for investigations of disease mechanisms and/or methods of treatment for this disease. EAMG can be induced in C57BL/6 (B6, H-2(b)) mice by 2-3 times injections at 4 weeks intervals with Torpedo californica (t) acetylcholine receptor (AChR) in complete Freund's adjuvant (CFA). However, the protocol especially with a two-injection schedule occasionally produces a poor incidence of EAMG. We have investigated the efficacy of the additional adjuvant, inactive organisms of Bordetella pertussis (iBP), on the induction with a two-injection schedule...
May 26, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28547379/concerning-the-importance-of-ontological-issues-for-cultural-psychology-a-reply-to-comments
#5
Irina A Mironenko
The paper continues the "ontological" discussion in IBPS, addressing the question of the importance of ontological issues for contemporary development of cultural psychology. The language psychological science speaks is considered as an ontological issue and a most topical one for cultural psychology, aiming at "constructing a psychology that is universal while being culture-inclusive" (Valsiner 2009, p.2). Ontological issues could stay implicit and neglected, as long as the 'etant, "the mode of being", "the particularities" were discussed within the circle of adherents of one and the same school, who implicitly had in mind the same 'entre...
May 25, 2017: Integrative Psychological & Behavioral Science
https://www.readbyqxmd.com/read/28545825/the-effect-of-anesthetic-drug-choice-on-accuracy-of-high-definition-oscillometry-in-laterally-recumbent-horses
#6
Tanya Duke-Novakovski, Barbara Ambros, Cindy Feng, Anthony P Carr
OBJECTIVE: To determine the accuracy of high-definition oscillometry (HDO) for arterial pressure measurement during injectable or inhalation anesthesia in horses. STUDY DESIGN: Prospective, clinical study. ANIMALS: Twenty-four horses anesthetized for procedures requiring lateral recumbency. METHODS: Horses were premedicated with xylazine, and anesthesia induced with diazepam-ketamine. Anesthesia was maintained with xylazine-ketamine-guaifenesin combination [TripleDrip (TD; n = 12) or isoflurane (ISO; n = 12)]...
January 11, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28544893/agreement-of-invasive-and-non-invasive-blood-pressure-measurements-in-anaesthetised-pigs-using-the-surgivet-v9203
#7
Philomena P Tuohy, Anthea L Raisis, Eleanor A Drynan
The automated oscillometric method is a common method for measuring blood pressure non-invasively and is broadly and confidently used in the veterinary setting. Twenty-one pigs undergoing anesthesia for exploratory laparotomy were enrolled in a study to evaluate the performance of the Surgivet V9203 non-invasive blood pressure (NIBP) monitor. The aim was to compare measurements of arterial blood pressure obtained simultaneously using the Surgivet V9203 oscillometric system and an intra-arterial catheter-transducer system, both at the level of the metatarsus...
May 19, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28543018/multiple-ice-binding-proteins-of-probable-prokaryotic-origin-in-an-antarctic-lake-alga-chlamydomonas-sp-ice-mdv-chlorophyceae
#8
James A Raymond
Ice-associated algae produce ice-binding proteins (IBPs) to prevent freezing damage. The IBPs of the three chlorophytes that have been examined so far share little similarity across species, making it likely that they were acquired by horizontal gene transfer (HGT). To clarify the importance and source of IBPs in chlorophytes, we sequenced the IBP genes of another Antarctic chlorophyte, Chlamydomonas sp. ICE-MDV (Chlamy-ICE). Genomic DNA and total RNA were sequenced and screened for known ice-associated genes...
May 19, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28540552/application-of-ruo2-ni-foam-electrodes-for-remediation-of-ibuprofen-in-soil-matrix-the-effect-of-electrokinetic-parameters
#9
Ching Yuan, Chung-Hsuang Hung, Tzu-Yuan Huang
Pharmaceuticals and personal care products (PPCPs) are an extraordinary and diverse group of chemicals used in veterinary medicine, agriculture, and for human health and cosmetics care. They are considered emerging contaminants and have raised great concern in recent years. Among the PPCPs, ibuprofen (IBP) is one of the most known non-steroidal anti-inflammatory drugs, which has been found at a high concentration in irrigation water in the USA and showed harmful effect for organisms. This study examined IBP degradation performance by an electrokinetic process coupled with 24-96 cm(2) of RuO2/Ni foam (RN) electrodes applied 1-3 V cm(-1) potential gradient for 5-9 days...
May 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28536822/assessment-of-typical-spa-lesions-on-mri-of-the-spine-do-local-readers-and-central-readers-agree-in-the-desir-cohort-at-baseline
#10
Manouk de Hooge, Jean-Baptiste Pialat, Monique Reijnierse, Désirée van der Heijde, Pascal Claudepierre, Alain Saraux, Maxime Dougados, Antoine Feydy
Comparing local reading (LocR) with central reading (CentR) of typical spondyloarhritis lesions including bone marrow edema (BME) and structural lesions on magnetic resonance imaging of the spine (MRI-spine), in patients with inflammatory back pain (IBP; ≥3 months, <3 years). Baseline data of 667 patients, age 18-50 years, from the Devenir des Spondylarthopathies Indifferenciees Recentes (DESIR)-cohort were used. Two trained central readers scored anterior and posterior corner BME, fatty lesions, erosions and syndesmophytes on MRI-spine...
May 23, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28528758/comparison-of-arterial-blood-pressure-measurements-obtained-invasively-or-oscillometrically-using-a-datex-s-5-compact-monitor-in-anaesthetised-adult-horses
#11
Tyfane T Yamaoka, Derek Flaherty, Patricia Pawson, Marian Scott, Adam Auckburally
OBJECTIVE: To assess agreement between noninvasive blood pressure (NIBP) oscillometrically-derived values from a multiparameter monitor (Datex Ohmeda S/5 Compact) with those obtained by invasive blood pressure (IBP) measurement in anaesthetised horses undergoing elective surgery. STUDY DESIGN: Prospective clinical study. ANIMALS: A total of 40 healthy adult horses. METHODS: Horses were anaesthetised with various anaesthetic protocols (based on clinical requirements)...
January 11, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28523202/identification-of-a-novel-alternatively-spliced-form-of-inflammatory-regulator-swap-70-like-adapter-of-t-cells
#12
Marie Hashimoto, Jun-Ichi Nagao, Shojiro Ikezaki, Sonoko Tasaki, Ken-Ichi Arita-Morioka, Yuka Narita, Tamaki Cho, Kenji Yuasa, Amnon Altman, Yoshihiko Tanaka
Activation of naive CD4(+) T cells results in the development of several distinct subsets of effector Th cells, including Th2 cells that play a pivotal role in allergic inflammation and helminthic infections. SWAP-70-like adapter of T cells (SLAT), also known as Def6 or IBP, is a guanine nucleotide exchange factor for small GTPases, which regulates CD4(+) T cell inflammatory responses by controlling Ca(2+)/NFAT signaling. In this study, we have identified a novel alternatively spliced isoform of SLAT, named SLAT2, which lacks the region encoded by exons 2-7 of the Def6 gene...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28523028/peripheral-arterial-blood-pressure-versus-central-crterial-blood-pressure-monitoring-in-critically-ill-patients-after-cardio-pulmonary-bypass
#13
Rana Altaf Ahmad, Suhail Ahmad, Anjum Naveed, Mirza Ahmad Raza Baig
OBJECTIVE: To determine the accuracy of peripheral (radial) arterial access as compared to central (femoral) arterial access for measurement of invasive blood pressure (IBP) in critically ill patients after cardiopulmonary bypass. METHODS: Sixty patients (60) who required high inotropic/vasopressor support on weaning from cardio-pulmonary bypass and weaned off in 2(nd) attempt were included in this study. The duration of this study was from June 2015 to August 2016...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28518108/identification-of-plant-ice-binding-proteins-through-assessment-of-ice-recrystallization-inhibition-and-isolation-using-ice-affinity-purification
#14
Melissa Bredow, Heather E Tomalty, Virginia K Walker
Ice-binding proteins (IBPs) belong to a family of stress-induced proteins that are synthesized by certain organisms exposed to subzero temperatures. In plants, freeze damage occurs when extracellular ice crystals grow, resulting in the rupture of plasma membranes and possible cell death. Adsorption of IBPs to ice crystals restricts further growth by a process known as ice-recrystallization inhibition (IRI), thereby reducing cellular damage. IBPs also demonstrate the ability to depress the freezing point of a solution below the equilibrium melting point, a property known as thermal hysteresis (TH) activity...
May 5, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28492508/inclusion-complexes-of-a-new-family-of-non-ionic-amphiphilic-dendrocalix-4-arene-and-poorly-water-soluble-drugs-naproxen-and-ibuprofen
#15
Khalid Khan, Syed Lal Badshah, Nasir Ahmad, Haroon Ur Rashid, Yahia Mabkhot
The inclusion complexes of a new family of nonionic amphiphilic calix[4]arenes with the anti-inflammatory hydrophobic drugs naproxen (NAP) and ibuprofen (IBP) were investigated. The effects of the alkyl chain's length and the inner core of calix[4]arenes on the interaction of the two drugs with the calix[4]arenes were explored. The inclusion complexes of Amphiphiles 1a-c with NAP and IBP increased the solubility of these drugs in aqueous media. The interaction of 1a-c with the drugs in aqueous media was investigated through fluorescence, molecular modeling, and ¹H-NMR analysis...
May 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28481446/how-different-are-g-protein-stabilized-agonist-gpcr-complexes-from-their-nanobody-stabilized-equivalents
#16
Noureldin Saleh, Passainte Ibrahim, Tim Clark
Protein nanobodies have been used successfully as surrogates for unstable G-proteins in order to crystallize G-protein coupled receptors (GPCRs) in their active states. We have now used molecular dynamics (MD) simulations including metadynamics enhanced sampling to investigate the similarities and differences between GPCR-agonist ternary complexes with the -subunits of the appropriate G-proteins and with the protein nanobodies (intracellular binding partners, IBPs) used for crystallization. In two of three receptors considered, the agonist binding mode differs significantly between the two alternative ternary complexes...
May 8, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28426912/the-association-between-inflammatory-back-pain-characteristics-and-mri-findings-in-the-spine-and-sacroiliac-joints
#17
Bodil Arnbak, Anne G Jurik, Tue S Jensen, Claus Manniche
OBJECTIVE: To investigate the association between MRI findings at the sacroiliac joints (SIJs) and vertebral endplates and pain characteristics assumed to be indicative of axial inflammation. METHODS: Patients aged 18-40 years with persistent low back pain referred to an outpatient spine clinic participated, including an unknown proportion of axial spondyloarthritis patients. Data included MRI of the spine and SIJs and self-reported responses to questions covering the Calin, Berlin, ASAS and Bailly inflammatory back pain (IBP) definitions...
April 20, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28422690/doubly-nonparametric-sparse-nonnegative-matrix-factorization-based-on-dependent-indian-buffet-processes
#18
Junyu Xuan, Jie Lu, Guangquan Zhang, Richard Yi Da Xu, Xiangfeng Luo
Sparse nonnegative matrix factorization (SNMF) aims to factorize a data matrix into two optimized nonnegative sparse factor matrices, which could benefit many tasks, such as document-word co-clustering. However, the traditional SNMF typically assumes the number of latent factors (i.e., dimensionality of the factor matrices) to be fixed. This assumption makes it inflexible in practice. In this paper, we propose a doubly sparse nonparametric NMF framework to mitigate this issue by using dependent Indian buffet processes (dIBP)...
April 12, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28419826/melting-process-of-the-peritectic-mixture-of-lidocaine-and-ibuprofen-interpreted-by-site-percolation-theory-model
#19
Hikaru Kataoka, Yoshinori Sakaki, Kazushi Komatsu, Yohsuke Shimada, Satoru Goto
Eutectic mixtures are often used in the design and delivery of drugs. In this study, we examined the peritectic mixture of lidocaine (LDC) and ibuprofen (IBP) using differential scanning calorimetry, Raman spectroscopy, and microscopy. The obtained phase diagram shows that as the mixture is heated, first LDC melts at 293 K, then IBP dissolves in the liquefied LDC at 310 K, and finally all remaining crystals melt. In the (1)H NMR spectra, the signals of the carboxyl group in IBP and amide or amine group in LDC shift to the low magnetic field in the IBP/LDC mixtures, because of the intermolecular interaction between these moieties...
April 15, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28415394/ultra-sensitive-detection-of-ibuprofen-ibp-by-electrochemical-aptasensor-using-the-dendrimer-quantum-dot-den-qd-bioconjugate-as-an-immobilization-platform-with-special-features
#20
Mahmoud Roushani, Faezeh Shahdost-Fard
This study describes a high-performance electrochemical aptasensor which is employed to detect Ibuprofen (IBP) as a painkiller drug by using a novel platform as an integrated sensing interface. In order to make the aptasensor, the Den-QD bioconjugate was immobilized on the surface of a GC electrode and followed the Apt was incubated on this surface. The incubation of the IBP on the aptasensor surface and the formation of the Apt/IBP complex, led to a hindered electron transfer reaction on the sensing surface, which decreased the peak current of the redox probe...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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