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Ciara Whitty, R John Wardale, Frances M D Henson
Sclerostin is a clinically important protein with key functions in the musculoskeletal system playing a key role in bone formation and remodelling. Whilst a wide range of mechanisms have been identified which regulate sclerostin expression, little is known about the degradation of the protein. The aim of this study was to identify enzymes capable of degrading sclerostin in peridontal ligament (PDL) fibroblasts cells in vitro and to investigate the functionality of these enzymes. We have demonstrated that cathepsin K cleaves sclerostin in vitro in PDL...
May 30, 2018: Biochemical and Biophysical Research Communications
L Ottria, L Tettamanti, M Gargari, G Valente, V Pacini, C Costanzo
This study has tested the effects of hyperbaric oxygen in periodontal structures in agreement with the theories supported by literature research. Eight patients, from 30 to 50 years-of-age, were tested with pure oxygen inhalation, at the 2.5 ATA absolute pressure. Main approved tests of periodontal health were evaluated before and after HBOT’s cycles. The results in all patients treated with HBOT, have founded clear improvement of clinical and instrumental parameters.
January 2018: Journal of Biological Regulators and Homeostatic Agents
Anju Gautam, Neelam Mittal, T B Singh, Ruchi Srivastava, Pushpendra Kumar Verma
BACKGROUND: The knowledge of the ABO blood group phenotype of the patients and their correlation with the periodontal disease maybe important in the development of early treatment strategies, and it would be helpful to target non-responding areas to periodontal therapy of the susceptible individuals. AIMS: The present study was conducted to determine whether there was any correlation between periodontal diseases and ABO blood groups and Rh factor. MATERIAL AND METHOD: This study was carried out on 537 subjects attending Faculty of Dental Sciences OPD in BHU...
April 2017: Contemporary Clinical Dentistry
Dragana Gabrić, Sven Seiwerth, Anja Baraba, Vanja Vučićević, Boras
OBJECTIVE: Ishemic bone disease has multifactorial etiologies. Cronic dental infections should be eliminated to prevent osteonecrosis of the jaw. CASE REPORT: We report an unusual case of osteonecrosis due to the pulpal-peridontal syndrome and subsequent pulp necrosis. A case of 38 year old woman who presented with exposed bone, 8 mm in diameter, in the lingual area of the right lower third molar. The patient was otherwise healthy and was not taking any medications...
March 2017: Acta Stomatologica Croatica
Rubén Abraham Domínguez-Pérez, Juan Pablo Loyola-Rodriguez, Carlos Abud-Mendoza, Angel Gabriel Alpuche-Solis, José Luis Ayala-Herrera, Rita Elizabeth Martínez-Martínez
OBJECTIVE: Historically, it has been shown that rheumatoid arthritis (RA) and periodontitis (PE) share pathophysiological similarities and possibly a genetic background. In order to elucidate the genetic background between both diseases, we evaluated the distributions of five SNPs genotypes and all the possible haplotypes composed in subjects with isolated RA, PE, combined diseases and healthy controls. MATERIALS AND METHODS: The study population consisted of 280 Mexican subjects...
May 2017: Acta Odontologica Scandinavica
Hui-Yong Xu, Er-Min Nie, Gang Deng, Ling-Zhi Lai, Feng-Yang Sun, Hua Tian, Fu-Chun Fang, Ya-Guang Zou, Bu-Ling Wu, Jun Ou-Yang
Orthodontic tooth movement is a process stimulated and maintained by external tensile stress; periodontal ligament remodeling serves an important role during this process. However, the function and underlying mechanism of periostin (PN) during orthodontic periodontal ligament remodeling remain unclear. The present study established in vitro and in vivo models of orthodontic treatment to investigate the expression levels of PN under conditions of external tensile stress load. These results indicated that tensile stress load increased the expression levels of PN in mouse peridontal ligaments and human periodontal ligament cells (hPDLCs), during orthodontic tooth movement...
April 2017: Molecular Medicine Reports
Y L Cao, M Qiao, Z H Xu, G M Zou, L L Ma, W G Li, B H Xu
OBJECTIVE: To explore the clinical characteristics of IgA nephropathy (IgAN) with severe chronic periodontitis and aggressive periodontitis. METHODS: A total of 436 hospitalized patients who underwent renal needle biopsy in the department of nephrology of China-Japan Friendship Hospital from November 2013 to December 2014 were recruited in the study and blindly had periodontal examination. The patients were divided into IgAN group and non-IgAN group according to the renal pathology...
January 5, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Anton Sculean, Akira Aoki, George Romanos, Frank Schwarz, Richard J Miron, Raluca Cosgarea
Antimicrobial photodynamic therapy (PDT) has attracted much attention for the treatment of pathogenic biofilm associated with peridontitis and peri-implantitis. However, data from randomized controlled clinical studies (RCTs) are limited and, to some extent, controversial, making it difficult to provide appropriate recommendations. Therefore, the aims of the present study were (a) to provide an overview on the current evidence from RCTs evaluating the potential clinical benefit for the additional use of PDT to subgingival mechanical debridement (ie, scaling and root planing) alone in nonsurgical periodontal therapy; and (b) to provide clinical recommendations for the use of PDT in periodontal practice...
October 2015: Dental Clinics of North America
Xianghui Feng, Lilei Zhu, Li Xu, Huanxin Meng, Li Zhang, Xiuyun Ren, Ruifang Lu, Yu Tian, Dong Shi, Xiane Wang
OBJECTIVE: To date, no information on the distribution of periodontal microorganisms among family members of Chinese patients with aggressive peridontitis (AgP) is available. The aim of the present study was to investigate the probability of transmission of eight periodontal microorganisms between patients with aggressive periodontitis and their family members. DESIGN: Saliva and pooled subgingival plaque samples were collected from 103 participants from 41 nuclear families (including 41 AgP probands, 19 mothers, 22 fathers, 21 siblings)...
March 2015: Archives of Oral Biology
Xiaodong Zhou, Wenyi Zhang, Xiaoli Liu, Wu Zhang, Yiming Li
Diabetes mellitus and periodontitis are both common, chronic diseases. It is generally accepted that the inter-relationship between diabetes mellitus and periodontitis is a two-way relationship, i.e. the presence of one condition tends to increases the risk and severity of the other, and vice versa. Mechanisms for this two-way relationship are largely unknown. Hyperlipidemia is a group of disorders characterized by an excess of lipids in the bloodstream. Hyperlipidemia increases the risk of diabetes and peridontitis...
April 2015: Archives of Oral Biology
Selma Jakupovic, Edin Cerjakovic, Alan Topcic, Muhamed Ajanovic, Alma Konjhodzic- Prcic, Amra Vukovic
INTRODUCTION: An abfraction lesion is a type of a non-carious cervical lesion (NCCL) that represents a sharp defect on the cervical part of tooth, caused by occlusal biomechanical forces. The largest prevalence of the NCCL is found on the mandibular first premolar. The goal of the study is, by means of a numerical method - the finite element method (FEM), in an appropriate computer program, conduct a stress analysis of the mandibular premolar under various static loads, with a special reference to the biomechanics of cervical tooth region...
August 2014: Acta Informatica Medica: AIM
Umair Ahmed, Farzeen Tanwir
PURPOSE: To present a short review of recent literature available on the association of periodontal and cardiovascular diseases (CVD) and the role of peridontal disease as a risk factor to exacerbate CVD. MATERIALS AND METHODS: A thorough search of articles was carried out on the databases PUBMED and MEDLINE on the association of periodontal and cardiovascular diseases (CVD). The selected literature included review articles, observational and case-control studies as well as randomised control trials...
2015: Oral Health & Preventive Dentistry
Ning Song, Fangli Lü, Shiguang Huang, Guicong Ding, Zhumin Zhou, Zhiqing Liao
OBJECTIVE: To examine the effect of aqueous extracts of Scutellaria baicalensis Georgi and Radix paeoniae Alba on periodontitis mice and compare the results of the two herbs for the treatment of the periodontitis mice. METHODS: Sixty-four SPF 12-week-old male Kunming mice were selected and randomly divided into four groups:Control group(C); Experimental periodontitis group (P):the peridontitis models in Kunming mice were prepared by wrapping silk ligature and inoculating with putative periodontopathic bacteria; Scutellaria baicalensis Georgi treatment group (SG): periodontitis was induced by the same method described above, the mice were gavaged with Scutellaria baicalensis Georgi; Radix paeoniae Alba treatment group (RG): periodontitis was induced by the same method described above, the mice were gavaged with Radix paeoniae Alba...
February 2014: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
Shaila V Kothiwale, Babasaheb R Desai, Veerappa A Kothiwale, Megha Gandhid, Savita Konin
PURPOSE: To investigate the association between maternal periodontal disease and its effect on haemoglobin levels and low birth weight infants. MATERIALS AND METHODS: This observational study included 770 mothers. Data regarding the periodontal status, pregnancy outcome variables, haemoglobin levels (Hb%) and other factors that may contribute to adverse pregnancy outcomes were collected. The data were analysed using the chi-square test and univariate logistic regression analysis...
2014: Oral Health & Preventive Dentistry
Rocío Santos-García, Benito Sánchez-Domínguez, Mario D Cordero, José V Rios-Santos, María R Jaramillo-Santos, Mariano H Climent, Pedro Bullon
OBJECTIVE: [corrected] Fibromyalgia (FM) is a chronic pain syndrome with unknown etiology, which affects predominantly women. Mitochondrial alteration could have a role in the pathophysilogical mechanisms of inflammatory conditions as FM and periodontitis. The aim of the present study was assay the relationship between both diseases and mitochondrial dysfunction. PATIENT AND METHODS: We study the presence of periodontitis in twelve patients diagnosed of FM and mitochondrial dysfunction described...
February 2012: Journal of Clinical and Experimental Dentistry
Brian Chee, Boram Park, P Mark Bartold
For many years an association between diabetes and periodontitis has been suspected. In more recent times this relationship has been suggested to be bidirectional with each condition being able to influence the other. In this review the two-way relationship between diabetes and periodontitis is considered. For this narrative review a very broad search strategy of the literature was developed using both EMBASE and MEDLINE (via PubMed) databases. The reference lists from the selected papers were also scanned, and this provided an additional source of papers for inclusion and further assessment...
December 2013: International Journal of Evidence-based Healthcare
Wiwat Pichayakorn, Prapaporn Boonme
The aims of this study were to find the optimal formulation for the preparation of metronidazole-loaded chitosan microparticles (MTZ-MPs) via an emulsion cross-linking process, and to compare the in vitro release of MTZ from hydrogels and films containing the drug in forms of MTZ-MPs and raw powders. The effects of emulsifier type and concentration, amount of cross-linking agent, cross-linking time, drug:chitosan ratio, form of drug adding and washing method on the properties of the MTZ-MPs were investigated...
April 1, 2013: Materials Science & Engineering. C, Materials for Biological Applications
S Barry, J Allotey, A M Brundler, M S Duggal
BACKGROUND: Cystic hygroma (CH) is a congenital malformation of the lymphatic system. It most commonly presents in the neck, and aetiological factors include environmental and genetic factors. CASE REPORT: A 13-year-old female presented with spontaneous dental pain affecting the maxillary left first and second permanent molar teeth. Medical history revealed a history of left sided cervico-facial-thoracic CH. She was diagnosed with periapical peridontitis and required extraction of both teeth...
December 2012: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
D K Maurya, N Mittal, K R Sharma, G Nath
Ayurvedic literature contains a wealth of information on the diagnosis and treatment of periodontal diseases. This article discusses the use of triphala in the treatment of such diseases.
October 1997: Ancient Science of Life
Thomas Wilson
No abstract text is available yet for this article.
October 2011: Texas Dental Journal
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