keyword
MENU ▼
Read by QxMD icon Read
search

Muscle wasting

keyword
https://www.readbyqxmd.com/read/29470824/turning-up-the-heat-an-evaluation-of-the-evidence-for-heating-to-promote-exercise-recovery-muscle-rehabilitation-and-adaptation
#1
REVIEW
Hamish McGorm, Llion A Roberts, Jeff S Coombes, Jonathan M Peake
Historically, heat has been used in various clinical and sports rehabilitation settings to treat soft tissue injuries. More recently, interest has emerged in using heat to pre-condition muscle against injury. The aim of this narrative review was to collate information on different types of heat therapy, explain the physiological rationale for heat therapy, and to summarise and evaluate the effects of heat therapy before, during and after muscle injury, immobilisation and strength training. Studies on skeletal muscle cells demonstrate that heat attenuates cellular damage and protein degradation (following in vitro challenges/insults to the cells)...
February 22, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29466448/a-dystrophic-duchenne-mouse-model-for-testing-human-antisense-oligonucleotides
#2
Marcel Veltrop, Laura van Vliet, Margriet Hulsker, Jill Claassens, Conny Brouwers, Cor Breukel, Jos van der Kaa, Margot M Linssen, Johan T den Dunnen, Sjef Verbeek, Annemieke Aartsma-Rus, Maaike van Putten
Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disease generally caused by reading frame disrupting mutations in the DMD gene resulting in loss of functional dystrophin protein. The reading frame can be restored by antisense oligonucleotide (AON)-mediated exon skipping, allowing production of internally deleted, but partially functional dystrophin proteins as found in the less severe Becker muscular dystrophy. Due to genetic variation between species, mouse models with mutations in the murine genes are of limited use to test and further optimize human specific AONs in vivo...
2018: PloS One
https://www.readbyqxmd.com/read/29463847/small-vessel-vasculopathy-due-to-aberrant-autophagy-in-lamp-2-deficiency
#3
Huan T Nguyen, Satoru Noguchi, Kazuma Sugie, Yoshiyuki Matsuo, Chuyen T H Nguyen, Hitoshi Koito, Ichiro Shiojima, Ichizo Nishino, Hiroyasu Tsukaguchi
Lysosomal associated membrane protein 2 (LAMP2) is physiologically implicated in autophagy. A genetic LAMP2 defect causes Danon disease, which consists of two major phenotypes of myopathy and cardiomyopathy. In addition, arteriopathy may manifest on rare occasions but the pathological basis remains unknown. We encountered two Danon families that developed small-vessel vasculopathy in the coronary or cerebral arteries. To investigate the underlying mechanisms, we characterized the biological features of LAMP-2-deficient mice and cultured cells...
February 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29459026/prevalence-and-risk-of-protein-energy-wasting-assessed-by-subjective-global-assessment-in-older-adults-with-advanced-chronic-kidney-disease-results-from-the-equal-study
#4
Karin Windahl, Gerd Faxén Irving, Tora Almquist, Maarit Korkeila Lidén, Moniek van de Luijtgaarden, Nicholas C Chesnaye, Pauline Voskamp, Peter Stenvinkel, Marian Klinger, Maciej Szymczak, Claudia Torino, Maurizio Postorini, Christiane Drechsler, Fergus J Caskey, Christoph Wanner, Friedo W Dekker, Kitty J Jager, Marie Evans
OBJECTIVES: Prevalence and risk factors for protein-energy wasting (PEW) are poorly studied in the nondialysis, older population with advanced chronic kidney disease (CKD). Our aim was to evaluate the prevalence of PEW in advanced stage CKD patients aged greater than 65 years. Furthermore, we aimed to describe risk factors for PEW in the overall study population and among obese individuals. DESIGN: Prospective observational cohort study. METHODS: The EQUAL study, a European Quality Study on treatment in advanced chronic kidney disease, is a multicenter prospective observational cohort study in six European countries...
February 16, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29458111/ppar%C3%AE-modulation-rescues-mitochondrial-fatty-acid-oxidation-defects-in-the-mdx-model-of-muscular-dystrophy
#5
Eric L Bell, Robert W Shine, Peter Dwyer, Lyndsay Olson, Jennifer Truong, Ross Fredenburg, Matthew Goddeeris, Dominique Stickens, Effie Tozzo
Duchenne muscular dystrophy (DMD) is a recessive, fatal X-linked disease that is characterized by progressive skeletal muscle wasting due to the absence of dystrophin, which is an a essential protein that bridges the inner cytoskeleton and extra-cellular matrix. This study set out to characterize the mitochondria in primary muscle satellite cell derived myoblasts from mdx mice and wild type control mice. Compared to wild type derived cells the mdx derived cells have reduced mitochondrial bioenergetics and have fewer mitochondria...
February 16, 2018: Mitochondrion
https://www.readbyqxmd.com/read/29454232/effects-of-mine-tailing-and-mixed-contamination-on-metals-trace-elements-accumulation-and-histopathology-of-the-chub-squalius-cephalus-tissues-evidence-from-three-differently-contaminated-sites-in-serbia
#6
Božidar Rašković, Vesna Poleksić, Stefan Skorić, Katarina Jovičić, Slađana Spasić, Aleksandar Hegediš, Nebojša Vasić, Mirjana Lenhardt
Chub (Squalius cephalus) specimens were collected in Korenita River seven months after spillover from the waste water of antimony mine tailing pond and compared with chub living in Kruščica reservoir (intended for water supply) and Međuvršje reservoir (influenced by intense emission of industrial, urban and rural wastewater). Concentrations of 15 elements (Al, As, B, Ba, Cd, Cr, Cu, Fe, Hg, Mn, Ni, Pb, Si, Sr, Zn) were determined in muscle, liver and gills of chub by inductively coupled plasma optical spectrometry (ICP-OES) and histopathological alterations in liver and gills were assessed...
February 14, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29452288/repetitive-tlr-3-activation-in-the-lung-induces-skeletal-muscle-adaptations-and-cachexia
#7
Ted G Graber, Brandy L Rawls, Bing Tian, William J Durham, Camille R Brightwell, Allan R Brasier, Blake B Rasmussen, Christopher S Fry
Due to immunosenescence, older adults are particularly susceptible to lung-based viral infections, with increased severity of symptoms in those with underlying chronic lung disease. Repeated respiratory viral infections produce lung maladaptations, accelerating pulmonary dysfunction. Toll like 3 receptor (TLR3) is a membrane protein that senses exogenous double-stranded RNA to activate the innate immune response to a viral infection. Polyinosinic-polycytidylic acid [poly(I:C)] mimics double stranded RNA and has been shown to activate TLR3...
February 13, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29446010/phosphaturic-mesenchymal-tumors-what-an-endocrinologist-should-know
#8
REVIEW
J M Boland, P J Tebben, A L Folpe
Tumor-induced osteomalacia (TIO), also known as "oncogenic osteomalacia", is a rare cause of osteomalacia. TIO often has an insidious onset characterized clinically by progressive muscle weakness and bone pain with fractures. The hallmark biochemical finding is a persistent low serum phosphorus concentration due to renal phosphate wasting. The vast majority of cases of TIO result from production of the phosphaturic hormone fibroblast growth factor 23 (FGF23) by a histologically distinctive mesenchymal tumor, termed "phosphaturic mesenchymal tumor" (PMT)...
February 14, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29439674/establishing-a-clinical-phenotype-for-cachexia-in-end-stage-kidney-disease-study-protocol
#9
Joanne Reid, Helen R Noble, Gary Adamson, Andrew Davenport, Ken Farrington, Denis Fouque, Kamyar Kalantar-Zadeh, John Mallett, C McKeaveney, S Porter, David S Seres, Joanne Shields, Adrian Slee, Miles D Witham, Alexander P Maxwell
BACKGROUND: Surveys using traditional measures of nutritional status indicate that muscle wasting is common among persons with end-stage kidney disease (ESKD). Up to 75% of adults undergoing maintenance dialysis show some evidence of muscle wasting. ESKD is associated with an increase in inflammatory cytokines and can result in cachexia, with the loss of muscle and fat stores. At present, only limited data are available on the classification of wasting experienced by persons with ESKD...
February 13, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29428474/low-skeletal-muscle-mass-outperforms-the-charlson-comorbidity-index-in-risk-prediction-in-patients-undergoing-pancreatic-resections
#10
D Wagner, K Marsoner, A Tomberger, J Haybaeck, J Haas, G Werkgartner, H Cerwenka, H Bacher, H J Mischinger, P Kornprat
INTRODUCTION: Low skeletal muscle mass is a known predictor of morbidity and mortality in patients undergoing major pancreatic surgeries. We sought to combine low skeletal muscle mass with established risk predictors to improve their prognostic capacity for postoperative outcome and morbidity. METHODS: As established parameters to predict preoperative mortality risk for patients, the ASA classification and the Charlson Comorbidity Index (CCI) were used. The Hounsfield Units Average Calculation (HUAC) was measured to define low skeletal muscle mass in 424 patients undergoing pancreatic resections for malignancies...
February 7, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29423219/the-effect-of-protein-supplementation-on-body-muscle-mass-and-fat-mass-in-post-bariatric-surgery-a-randomized-controlled-trial-rct-study-protocol
#11
Sahar D Al-Shamari, Mohamed Aly ElSherif, Wahiba Hamid, Fahad Hanna
Background: Severe weight loss through means of bariatric surgery has been associated with loss of muscle mass due to lack of absorption of protein. The aim of this RCT is to investigate the effectiveness of protein supplementation in reducing the risk of developing protein malnutrition and muscle wasting in post-bariatric surgery patients in Qatar. Methods and analysis: The study was based at the Department of bariatric and metabolic surgery, Doha metropolitan and regional areas...
2018: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29417752/silver-linings-on-the-horizon-highlights-from-the-10th-cachexia-conference
#12
Nicole Ebner, Stephan von Haehling
This article highlights the updates from preclinical and clinical studies into the field of wasting disorders that were presented at the 10th Cachexia Conference held in Rome, Italy, in December 2017. This year's conference saw some interesting results of larger-scale studies and clinical trials and new therapeutic targets. Herein, we summarize the biological and clinical significance of different markers and new diagnostic tools and cut-offs for the detection of skeletal muscle wasting, including micro RNAs, the ubiquitin-proteasome system, mTOR signalling, news in body composition analysis including the D3-creatine dilution method, and new biomarkers...
February 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29415881/tak1-regulates-skeletal-muscle-mass-and-mitochondrial-function
#13
Sajedah M Hindi, Shuichi Sato, Guangyan Xiong, Kyle R Bohnert, Andrew A Gibb, Yann S Gallot, Joseph D McMillan, Bradford G Hill, Shizuka Uchida, Ashok Kumar
Skeletal muscle mass is regulated by a complex array of signaling pathways. TGF-β-activated kinase 1 (TAK1) is an important signaling protein, which regulates context-dependent activation of multiple intracellular pathways. However, the role of TAK1 in the regulation of skeletal muscle mass remains unknown. Here, we report that inducible inactivation of TAK1 causes severe muscle wasting, leading to kyphosis, in both young and adult mice.. Inactivation of TAK1 inhibits protein synthesis and induces proteolysis, potentially through upregulating the activity of the ubiquitin-proteasome system and autophagy...
February 8, 2018: JCI Insight
https://www.readbyqxmd.com/read/29408692/proteomic-analysis-of-the-sarcolemma-enriched-fraction-from-dystrophic-mdx-4cv-skeletal-muscle
#14
Sandra Murphy, Margit Zweyer, Michael Henry, Paula Meleady, Rustam R Mundegar, Dieter Swandulla, Kay Ohlendieck
The highly progressive neuromuscular disorder dystrophinopathy is triggered by primary abnormalities in the Dmd gene, which causes cytoskeletal instability and loss of sarcolemmal integrity. Comparative organellar proteomics was employed to identify sarcolemma-associated proteins with an altered concentration in dystrophic muscle tissue from the mdx-4cv mouse model of dystrophinopathy. A lectin agglutination method was used to prepare a sarcolemma-enriched fraction and resulted in the identification of 190 significantly changed protein species...
February 1, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29407164/inhibition-of-the-proteasome-partially-attenuates-atrophy-in-botulinum-neurotoxin-treated-skeletal-muscle
#15
Fraser E Houston, Brian A Hain, Stephen L Dodd
Botulinum neurotoxin type A (BoNT/A) is used as a therapeutic tool to induce chemical denervation of spastically contracted muscles, yet the neurotoxin can also cause skeletal muscle atrophy. The underlying proteolytic mechanisms that induce this atrophy remain unclear. Our previous work has highlighted increased ubiquitin proteasome system (UPS) activity in soleus muscle of male Sprague Dawley rats following hind limb injection of BoNT/A, with the chymotrypsin-like activity of the 20s proteasome the most active...
February 3, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29397579/%C3%AE-motor-neurons-are-spared-from-aging-while-their-synaptic-inputs-degenerate-in-monkeys-and-mice
#16
Nicholas Maxwell, Ryan W Castro, Natalia M Sutherland, Kelli L Vaughan, Mark D Szarowicz, Rafael de Cabo, Julie A Mattison, Gregorio Valdez
Motor function deteriorates with advancing age, increasing the risk of adverse health outcomes. While it is well established that skeletal muscles and neuromuscular junctions (NMJs) degenerate with increasing age, the effect of aging on α-motor neurons and their innervating synaptic inputs remains largely unknown. In this study, we examined the soma of α-motor neurons and innervating synaptic inputs in the spinal cord of aged rhesus monkeys and mice, two species with vastly different lifespans. We found that, in both species, α-motor neurons retain their soma size despite an accumulation of large amounts of cellular waste or lipofuscin...
February 4, 2018: Aging Cell
https://www.readbyqxmd.com/read/29397466/evaluation-of-mercury-lead-and-cadmium-in-the-waste-material-of-crevalle-jack-fish-from-the-gulf-of-urab%C3%A3-colombian-caribbean-as-a-possible-raw-material-in-the-production-of-sub-products
#17
Sara Elisa Gallego Ríos, Claudia María Ramírez Botero, Beatriz Estella López Marín, Claudia M Velásquez Rodríguez
The Gulf of Urabá, currently considered a national strategic ecoregion, could be threatened by the presence of heavy metals such as mercury (Hg), lead (Pb), and cadmium (Cd), which directly affect the aquatic ecosystem. In Colombia, investigations on marine species pollution are scarce; however, their products are consumed. The aim of this study was to quantify the contents of Hg, Pb, and Cd in muscle and in waste material (head-gills, viscera, fins-tail), in one of one of the most commercialized resources, the crevalle jack (Caranx hippos), and to determine their presence in some of the body portions that are used in the production of sub-products...
February 3, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29397069/characterisation-of-the-biological-response-of-saccharomyces-cerevisiae-to-the-loss-of-an-allele-of-the-eukaryotic-initiation-factor-4a
#18
Veronica Venturi, Richard Little, Peter W Bircham, Juliana Rodigheri Brito, Paul H Atkinson, David R Maass, Paul H Teesdale-Spittle
The translation initiation machinery is emerging as an important target for therapeutic intervention, with potential in the treatment of cancer, viral infections, and muscle wasting. Amongst the targets for pharmacological control of translation initiation is the eukaryotic initiation factor 4A (eIF4A), an RNA helicase that is essential for cap-dependent translation initiation. We set out to explore the system-wide impact of a reduction of functional eIF4A. To this end, we investigated the effect of deletion of TIF1, one of the duplicate genes that produce eIF4A in yeast, through synthetic genetic array interactions and system-wide changes in GFP-tagged protein abundances...
January 31, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29396542/blocking-extracellular-activation-of-myostatin-as-a-strategy-for-treating-muscle-wasting
#19
M Pirruccello-Straub, J Jackson, S Wawersik, M T Webster, L Salta, K Long, W McConaughy, A Capili, C Boston, G J Carven, N K Mahanthappa, K J Turner, A Donovan
Many growth factors are intimately bound to the extracellular matrix, with regulated processing and release leading to cellular stimulation. Myostatin and GDF11 are closely related members of the TGFβ family whose activation requires two proteolytic cleavages to release the growth factor from the prodomain. Specific modulation of myostatin and GDF11 activity by targeting growth factor-receptor interactions has traditionally been challenging. Here we demonstrate that a novel strategy for blocking myostatin and GDF11, inhibition of growth factor release, specifically and potently inhibits signaling both in vitro and in vivo...
February 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29393052/unilateral-muscle-artifacts-due-to-non-compliance-during-uptake-phase-of-18f-fdg-pet-ct-in-an-oncologic-patient
#20
William Makis, Emmanuel W Hudson
A 49-year-old male patient with a prior history of poor compliance with medical appointments was referred for an 18F-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) for the staging of a rectal squamous cell carcinoma. The PET/CT showed unilateral diffuse skeletal muscle 18F-FDG uptake as well as bilateral salivary gland uptake artifacts, suggestive of non-compliance with patient preparation instructions. The PET/CT nurse noted that during the 18F-FDG uptake phase, the patient appeared intoxicated, and she found two beer cans hidden in the waste disposal beside his chair just prior to imaging...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
keyword
keyword
93446
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"