keyword
MENU ▼
Read by QxMD icon Read
search

phase I

keyword
https://www.readbyqxmd.com/read/28938170/aromatic-hydrazones-derived-from-nicotinic-acid-hydrazide-as-fluorimetric-ph-sensing-molecules-structural-analysis-by-computational-and-spectroscopic-methods-in-solid-phase-and-in-solution
#1
T Benković, A Kenđel, J Parlov-Vuković, D Kontrec, V Chiş, S Miljanić, N Galić
Structural analyses of aroylhydrazones were performed by computational and spectroscopic methods (solid state NMR, 1 and 2D NMR spectroscopy, FT-IR (ATR) spectroscopy, Raman spectroscopy, UV-Vis spectrometry and spectrofluorimetry) in solid state and in solution. The studied compounds were N'-(2,3-dihydroxyphenylmethylidene)-3-pyridinecarbohydrazide (1), N'-(2,5-dihydroxyphenylmethylidene)-3-pyridinecarbohydrazide (2), N'-(3-chloro-2-hydroxy-phenylmethylidene)-3-pyridinecarbohydrazide (3), and N'-(2-hydroxy-4-methoxyphenyl-methylidene)-3-pyridinecarbohydrazide (4)...
September 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28937270/feasibility-of-free-breathing-lung-mri-for-radiotherapy-using-non-cartesian-k-space-acquisition-schemes
#2
Shivani Kumar, Robba Rai, Alto Stemmer, Sonal Josan, Lois Holloway, Shalini Vinod, Daniel Moses, Gary Liney
OBJECTIVES: To test a free breathing MRI protocol for anatomical and functional assessment during lung cancer radiotherapy by assessing two non-cartesian acquisition schemes based on a T1W 3D gradient recall echo sequence: (i) stack-of stars (StarVIBE) and (ii) spiral (SpiralVIBE) trajectories Methods: MR images on five healthy volunteers were acquired on a wide bore 3T scanner (Skyra, Siemens Healthcare). Anatomical image quality was assessed on: (1) free breathing (StarVIBE), (2) the standard clinical sequence (VIBE) acquired in a 20 second compliant breath-hold and (3) 20 second non-complaint breath-hold...
September 13, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28937215/infrared-spectroscopy-of-the-entrance-channel-complex-formed-between-the-hydroxyl-radical-and-methane-in-helium-nanodroplets
#3
Paul L Raston, Emmanuel I Obi, Gary E Douberly
The entrance channel complex in the exothermic OH + CH4 → H2O + CH3 reaction has been isolated in helium nanodroplets following the sequential pick-up of the hydroxyl radical and methane. The a-type OH stretching band was probed with infrared depletion spectroscopy, revealing a qualitatively similar spectrum to that previously reported in the gas phase, but with additional substructure that is due to the different internal rotation states of methane (jCH4 = 0, 1, or 2) in the complex. We fit the spectra by assuming the rotational constants of the complex are the same for all internal rotation states; however, subband origins are found to decrease with increasing jCH4...
September 22, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28937211/asymmetric-conjugated-molecules-based-on-1-benzothieno-3-2-b-1-benzothiophene-for-high-mobility-organic-thin-film-transistors-influence-of-alkyl-chain-length
#4
Keqiang He, Weili Li, Hongkun Tian, Jidong Zhang, Donghang Yan, Yanhou Geng, Fosong Wang
We herein report the synthesis and characterization of a series of [1]benzothieno[3,2-b][1]benzothiophene (BTBT)-based asymmetric conjugated molecules, i.e., 2-(5-alkylthiophen-2-yl)[1]benzothieno[3,2-b][1]benzothiophene (BTBT-Tn, in which T and n represent thiophene and the number of carbons in the alkyl group, respectively). All the molecules with n ≥ 4 show mesomorphism and display smectic A, smectic B (n = 4) or smectic E (n > 4) phases and then crystalline phases in succession upon cooling from the isotropic state...
September 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28937041/evaluation-of-circulating-endometrial-cells-as-a-biomarker-for-endometriosis
#5
Ying Chen, Hong-Lan Zhu, Zhe-Wen Tang, Kuang Hong Neoh, Dong-Fang Ouyang, Heng Cui, Hong-Yan Cheng, Rui-Qiong Ma, Xue Ye, Ray Ps Han, Xiao-Hong Chang
BACKGROUND: Circulating endometrial cells (CECs) have been reported to be present in the peripheral blood of women with endometriosis (EM), providing clear and specific evidence of the presence of ectopic lesions. In this study, we established a method with a high detection rate of CECs, assessed the diagnostic value of CECs for EM and compared with serum CA125, and proposed a hypothesis for the pathogenesis of EM from the new perspective of CECs. METHODS: The participants were enrolled prospectively from October 2015 to July 2016...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28936951/-preliminary-evaluation-of-sequential-therapy-by-high-flow-nasal-cannula-oxygen-therapy-following-endotracheal-tube-extubation-in-mechanically-ventilated-patients
#6
Zhengfang Zhu, Yuhao Liu, Qixing Wang, Sheng Wang
OBJECTIVE: To evaluate the feasibility and effect of sequential treatment by the heated humidified high flow nasal cannula oxygen therapy (HFNC) in mechanically ventilated patients following endotracheal tube extubation. METHODS: A prospective randomized controlled trial was conducted. Forty-nine patients with the sequential treatment after tracheal intubation extraction admitted to Department of Critical Care Medicine of Shanghai Tenth People's Hospital from January 1st to December 31st 2016 were enrolled...
September 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28936722/kinetics-of-photosystem-ii-electron-transport-a-mathematical-analysis-based-on-chlorophyll-fluorescence-induction
#7
Agu Laisk, Vello Oja
The OJDIP rise in chlorophyll fluorescence during induction at different light intensities was mathematically modeled using 24 master equations describing electron transport through photosystem II (PSII) plus ordinary differential equations for electron budgets in plastoquinone, cytochrome f, plastocyanin, photosystem I, and ferredoxin. A novel feature of the model is consideration of electron in- and outflow budgets resulting in changes in redox states of Tyrosine Z, P680, and QA as sole bases for changes in fluorescence yield during the transient...
September 21, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28936607/time-of-flight-mr-angiography-in-cerebral-venous-sinus-thrombosis
#8
Dimitri Renard, Emmanuelle Le Bars, Caroline Arquizan, Nicolas Gaillard, Nicolas Menjot de Champfleur, Isabelle Mourand
Recently, time-of-flight (TOF) and gadolinium-enhanced MR angiography (MRA) imaging have been used to demonstrate subacute intramural hematoma in cervical artery dissection and to detect intraplaque haemorrhage. Our aim was to perform an exploratory study to analyse if venous thrombus-related signal changes (potentially showing iso- or hyperintensity) in cerebral venous sinus thrombosis (CVST) could be observed on 3D-TOF MRA imaging. We analysed retrospectively MRIs of CVST patients in whom both contrast-enhanced MR venography (CEMRV) and 3D-TOF sequences were performed in the acute/subacute phase (i...
September 21, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28936510/low-temperature-and-high-pressure-phases-of-a-room-temperature-ionic-liquid-and-polyiodides-1-methyl-3-propylimidazolium-iodide
#9
Hiroshi Abe, Hiroaki Kishimura, Mayumi Takaku, Mai Watanabe, Nozomu Hamaya
Using simultaneous small-angle X-ray scattering (SAXS) combined with differential scanning calorimetry (DSC) and wide-angle X-ray scattering (WAXS) combined with DSC measurements, low-temperature (LT) solid phases of a room-temperature ionic liquid (RTIL) and its mixtures were examined at ambient pressure. The considered RTIL was 1-methyl-3-propylimidazolium iodide ([C3mim][I]), and the mixtures could be expressed as [C3mim][Im]. Under high-pressure (HP), the crystallization of pure [C3mim][I] was suppressed, as a LT-amorphous form of pure [C3mim][I] was formed...
September 22, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28935942/oxygen-evolution-reaction-dynamics-monitored-by-an-individual-nanosheet-based-electronic-circuit
#10
Peiyao Wang, Mengyu Yan, Jiashen Meng, Gengping Jiang, Longbing Qu, Xuelei Pan, Jefferson Zhe Liu, Liqiang Mai
The oxygen evolution reaction involves complex interplay among electrolyte, solid catalyst, and gas-phase and liquid-phase reactants and products. Monitoring catalysis interfaces between catalyst and electrolyte can provide valuable insights into catalytic ability. But it is a challenging task due to the additive solid supports in traditional measurement. Here we design a nanodevice platform and combine on-chip electrochemical impedance spectroscopy measurement, temporary I-V measurement of an individual nanosheet, and molecular dynamic calculations to provide a direct way for nanoscale catalytic diagnosis...
September 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28935857/sensorimotor-computation-underlying-phototaxis-in-zebrafish
#11
Sébastien Wolf, Alexis M Dubreuil, Tommaso Bertoni, Urs Lucas Böhm, Volker Bormuth, Raphaël Candelier, Sophia Karpenko, David G C Hildebrand, Isaac H Bianco, Rémi Monasson, Georges Debrégeas
Animals continuously gather sensory cues to move towards favourable environments. Efficient goal-directed navigation requires sensory perception and motor commands to be intertwined in a feedback loop, yet the neural substrate underlying this sensorimotor task in the vertebrate brain remains elusive. Here, we combine virtual-reality behavioural assays, volumetric calcium imaging, optogenetic stimulation and circuit modelling to reveal the neural mechanisms through which a zebrafish performs phototaxis, i.e...
September 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28935542/phase-i-trial-of-veliparib-a-poly-adp-ribose-polymerase-inhibitor-plus-metronomic-cyclophosphamide-in-metastatic-her2-negative-breast-cancer
#12
Jesus Anampa, Alice Chen, John Wright, Margi Patel, Christine Pellegrino, Karen Fehn, Joseph A Sparano, Eleni Andreopoulou
BACKGROUND: Poly-ADP-ribose-polymerase is an essential nuclear enzyme, involved in base-excision repair of damaged DNA. Poly-ADP-ribose-polymerase inhibition sensitizes tumor cells to cytotoxic agents, which induce DNA damage, including cyclophosphamide (C), and metronomic dosing of C may optimize potential for synergy. METHODS: The primary objective of this phase I trial was to determine the safety and identify the recommended phase II dose of the combination of low-dose oral C (50, 75, 100, and 125 mg) once daily in combination with veliparib (V) (100, 200, and 300 mg) administered twice a day (BID) for 21-day cycles using a standard 3 + 3 design in patients with metastatic human epidermal growth factor receptor 2/neu-negative breast cancer...
September 1, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28935457/-development-and-implementation-of-an-outpatient-clinic-at-an-initial-reception-centre-for-asylum-seekers-in-the-german-federal-state-of-baden-wuerttemberg
#13
C Nikendei, D Huhn, G Adler, P Becker von Rose, T M Eckstein, B Fuchs, S C Gewalt, B Greiner, T Günther, W Herzog, T Junghanss, T Krczal, D Lorenzen, T Lutz, M A Manigault, N Reinhart, M Rodenberg, I Schelletter, J Szecsenyi, R Steen, C Straßner, M Thomsen, K Wahedi, K Bozorgmehr
In 2015, more than 890,000 asylum seekers were registered in Germany. The provision of medical and psychosocial care for asylum seekers is facing numerous obstacles. Access to health care is mostly insufficient, particularly in initial reception centres. The present article describes the development and implementation of an interdisciplinary outpatient clinic for asylum seekers at the main registration authority in the state of Baden-Wuerttemberg operated by physicians of the University Hospital of Heidelberg and the local Medical Association in Heidelberg...
September 19, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28935273/a-multicenter-open-label-expanded-phase-2-study-to-evaluate-the-safety-and-efficacy-of-etirinotecan-pegol-a-polymer-conjugate-of-irinotecan-in-women-with-recurrent-platinum-resistant-or-refractory-ovarian-cancer
#14
G Rustin, I Vergote, J P Micha, L R Duska, N Reed, J Bendell, D Spitz, G Dark, U Hoch, M Tagliaferri, A L Hannah, A A Garcia
OBJECTIVE: Etirinotecan pegol (EP) is a novel polyethylene glycol conjugated form of irinotecan with documented activity in platinum-resistant ovarian cancer (PROC). We report the results of the expanded portion of a phase II study of EP in patients with PROC who received prior pegylated liposomal doxorubicin (PLD) or who were unable to receive it. METHODS: This multicenter, open-label, phase II study evaluated EP q21d for PROC. The primary endpoint was objective response rate (ORR) by Response Evaluation Criteria in Solid Tumors version 1...
September 18, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28935006/novel-h-shunt-venovenous-bypass-for-liver-transplantation-in-cynomolgus-macaques
#15
Yojiro Kato, Adam D Griesemer, Anette Wu, Hugo P Sondermeijer, Joshua I Weiner, Raimon Duran-Struuck, Mercedes Martinez, Andrea R Slate, Alexander Romanov, Jay H Lefkowitch, Megan Sykes, Tomoaki Kato
Cynomolgus monkeys are often used in preclinical transplantation research. Performing liver transplantation in cynomolgus monkeys is challenging because they poorly tolerate portal vein clamping during the anhepatic phase. Finding an alternative to portal vein clamping is necessary before preclinical liver transplant models can be performed with reliable outcomes. We used 3 different techniques to perform 5 liver transplants in male cynomolgus macaques (weight, 7.4-10.8 kg; mismatched for MHC I and II; matched for ABO)...
October 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28934961/area-asymmetry-of-heart-rate-variability-signal
#16
Chang Yan, Peng Li, Lizhen Ji, Lianke Yao, Chandan Karmakar, Changchun Liu
BACKGROUND: Heart rate fluctuates beat-by-beat asymmetrically which is known as heart rate asymmetry (HRA). It is challenging to assess HRA robustly based on short-term heartbeat interval series. METHOD: An area index (AI) was developed that combines the distance and phase angle information of points in the Poincaré plot. To test its performance, the AI was used to classify subjects with: (i) arrhythmia, and (ii) congestive heart failure, from the corresponding healthy controls...
September 21, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28934639/changes-in-nursing-students-expectations-of-nursing-clinical-faculties-competences-a-longitudinal-mixed-methods-study
#17
Robert Lovrić, Nada Prlić, Dragana Milutinović, Igor Marjanac, Boštjan Žvanut
BACKGROUND: Changes in nursing students' expectations of their clinical nursing faculty competences over the course of time are an insufficiently researched phenomenon. OBJECTIVES: To explore what competences BSc nursing students expect from their clinical faculties during their clinical training, and whether their expectations changed during their three-year studies. Furthermore, to survey factors which influenced their expectations and whether the fulfilment levels of their expectations influenced their feelings, learning, and behaviour...
September 8, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28934360/pkacs-attenuate-innate-antiviral-response-by-phosphorylating-visa-and-priming-it-for-march5-mediated-degradation
#18
Bing-Ru Yan, Lu Zhou, Ming-Ming Hu, Mi Li, Heng Lin, Yan Yang, Yan-Yi Wang, Hong-Bing Shu
Sensing of viral RNA by RIG-I-like receptors initiates innate antiviral response, which is mediated by the central adaptor VISA. How the RIG-I-VISA-mediated antiviral response is terminated at the late phase of infection is enigmatic. Here we identified the protein kinase A catalytic (PKAC) subunits α and β as negative regulators of RNA virus-triggered signaling in a redundant manner. Viral infection up-regulated cellular cAMP levels and activated PKACs, which then phosphorylated VISA at T54. This phosphorylation abrogated virus-induced aggregation of VISA and primed it for K48-linked polyubiquitination and degradation by the E3 ligase MARCH5, leading to attenuation of virus-triggered induction of downstream antiviral genes...
September 21, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28934314/mode-of-action-of-plectasin-derived-peptides-against-gas-gangrene-associated-clostridium-perfringens-type-a
#19
Xueling Zheng, Xiumin Wang, Da Teng, Ruoyu Mao, Ya Hao, Na Yang, Lifen Zong, Jianhua Wang
NZ2114 and MP1102 are novel plectasin-derived peptides with potent activity against Gram-positive bacteria. The antibacterial characteristics and mechanism of NZ2114 and MP1102 against gas gangrene-associated Clostridium perfringens were studied for the first time. The minimal inhibitory concentration and minimal bactericidal concentration of NZ2114 and MP1102 against resistant C. perfringens type A strain CVCC 46 were 0.91 μM. Based on the fractional inhibitory concentration index (FICI) result, an additive or synergic effect was observed between NZ2114 (FICI = 0...
2017: PloS One
https://www.readbyqxmd.com/read/28934287/priming-effects-on-labile-and-stable-soil-organic-carbon-decomposition-pulse-dynamics-over-two-years
#20
Xiuwei Zhang, Xiaozeng Han, Wantai Yu, Peng Wang, Weixin Cheng
Soil organic carbon (SOC) is a major component in the global carbon cycle. Yet how input of plant litter may influence the loss of SOC through a phenomenon called priming effect remains highly uncertain. Most published results about the priming effect came from short-term investigations for a few weeks or at the most for a few months in duration. The priming effect has not been studied at the annual time scale. In this study for 815 days, we investigated the priming effect of added maize leaves on SOC decomposition of two soil types and two treatments (bare fallow for 23 years, and adjacent old-field, represent stable and relatively labile SOC, respectively) of SOC stabilities within each soil type, using a natural 13C-isotope method...
2017: PloS One
keyword
keyword
93445
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"