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https://www.readbyqxmd.com/read/28641369/markers-of-inflammation-and-incident-breast-cancer-risk-in-the-women-s-health-study
#1
Deirdre K Tobias, Akintunde O Akinkuolie, Paulette D Chandler, Patrick R Lawler, JoAnn E Manson, Julie E Buring, Paul M Ridker, Lu Wang, I-Min Lee, Samia Mora
Chronic inflammation may be a risk factor for breast cancer development and progression, yet which inflammatory biomarkers and pathways are relevant is unknown. The study included 27,071 Women's Health Study participants (mean, 54.5 years old) free of cancer and cardiovascular disease at enrollment (1992 to 1995) with baseline measures of four inflammatory biomarkers: high sensitivity C-reactive protein (hsCRP), fibrinogen, N-acetyl side-chains of acute phase proteins (GlycA), and soluble intercellular adhesion molecule-1 (sICAM-1)...
June 21, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28641357/-the-german-thorax-registry-implementation-of-an-established-tool-of-perioperative-health-care-research
#2
Jérôme Defosse, Mark Schieren, Torsten Loop, Cerstin Arndt, Rainer Röhrig, Erich Stoelben, Corinna Ludwig, Alexander Schleppers, Frank Wappler, Mark Gerbershagen, Alberto Lopez-Pastorini
The collection of clinical treatment data in registry databases is an important aspect of health services research. It allows for a critical evaluation of the safety, efficacy and cost-effectiveness of clinical treatment concepts in large patient populations. The findings of registry research represent real-world patients and treatment structures as they are not limited by strict inclusion criteria or unrealistic conditions as applied in prospective clinical trials. The implementation of the German Thorax Registry has enabled the collection and analysis of data on the interdisciplinary care (thoracic surgery, anaesthesiology, intensive care, pain management) of patients undergoing thoracic surgery...
June 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28641195/biotransformation-in-the-zebrafish-embryo-temporal-gene-transcription-changes-of-cytochrome-p450-enzymes-and-internal-exposure-dynamics-of-the-ahr-binding-xenobiotic-benz-a-anthracene
#3
Agnes Kühnert, Carolina Vogs, Bettina Seiwert, Silke Aulhorn, Rolf Altenburger, Henner Hollert, Eberhard Küster, Wibke Busch
Not much is known about the biotransformation capability of zebrafish (Danio rerio) embryos. For understanding possible toxicity differences to adult fish, it might be crucial to understand the biotransformation of chemicals in zebrafish embryos i.e. as part of toxicokinetics. The biotransformation capabilities were analysed for two different stages of zebrafish embryos in conjunction with the internal concentrations of a xenobiotic. Zebrafish embryos of the late cleavage/early blastula period (2-26 hpf) and the early pharyngula period (26-50 hpf) were exposed for 24 h to the AhR binding compound benz[a]anthracene (BaA)...
June 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28641182/unraveling-the-complexities-of-the-velocity-dependency-of-e-coli-retention-and-release-parameters-in-saturated-porous-media
#4
Salini Sasidharan, Scott A Bradford, Saeed Torkzaban, Xueyan Ye, Joanne Vanderzalm, Xinqiang Du, Declan Page
Escherichia coli transport and release experiments were conducted to investigate the pore-water velocity (v) dependency of the sticking efficiency (α), the fraction of the solid surface area that contributed to retention (Sf), the percentage of injected cells that were irreversibly retained (Mirr), and cell release under different (10-300mM) ionic strength (IS) conditions. Values of α, Sf, and Mirr increased with increasing IS and decreasing v, but the dependency on v was greatest at intermediate IS (30 and 50mM)...
June 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28641127/deep-brain-stimulation-of-subthalamic-nucleus-helps-in-improving-late-phase-motor-planning-in-parkinson-s-disease
#5
Patil Ashlesh, Sood Sanjay Kumar, Kochhar Kanwal Preet, Goyal Vinay
OBJECTIVE: Deep brain stimulation of subthalamic nucleus (DBS-STN) is a well-accepted treatment for Parkinson's disease (PD) but its effect on motor planning in the disease is yet unclear. This study examines the effect of switching the stimulation ON and OFF on components of bereitschaftspotentials in PD. PATIENTS AND METHODS: Scalp bereitschaftspotentials were recorded during self-paced right wrist extensions at Fz, Cz, Pz, C3 and C4 sites in patients on DBS-STN plus medications (DBS-STN group) as treatment modality or on medications only (Med group) and compared with age matched healthy controls...
June 15, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28640923/how-much-detail-is-needed-in-modeling-a-transcranial-magnetic-stimulation-figure-8-coil-measurements-and-brain-simulations
#6
Petar I Petrov, Stefano Mandija, Iris E C Sommer, Cornelis A T van den Berg, Sebastiaan F W Neggers
BACKGROUND: Despite TMS wide adoption, its spatial and temporal patterns of neuronal effects are not well understood. Although progress has been made in predicting induced currents in the brain using realistic finite element models (FEM), there is little consensus on how a magnetic field of a typical TMS coil should be modeled. Empirical validation of such models is limited and subject to several limitations. METHODS: We evaluate and empirically validate models of a figure-of-eight TMS coil that are commonly used in published modeling studies, of increasing complexity: simple circular coil model; coil with in-plane spiral winding turns; and finally one with stacked spiral winding turns...
2017: PloS One
https://www.readbyqxmd.com/read/28640770/physiological-responses-and-time-motion-analysis-of-small-combat-games-in-kickboxing-impact-of-ring-size-and-number-of-within-round-sparring-partners
#7
Ibrahim Ouergui, Nizar Houcine, Hamza Marzouki, Philip Davis, Emerson Franchini, Nabil Gmada, Ezzedine Bouhlel
Ouergui, I, Houcine, N, Marzouki, H, Davis, P, Franchini, E, Gmada, N, and Bouhlel, E. Physiological responses and time-motion analysis of small combat games in kickboxing: impact of ring size and number of within-round sparring partners. J Strength Cond Res 31(7): 1840-1846, 2017-The study aimed to investigate the physiological responses and time-structure of small combat games (SCGs) in kickboxing according to ring sizes and number of sparring partners. Twenty athletes from regional (n = 13) and national levels (n = 7) participated in the study (mean ± SD, age: 20...
July 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28640759/electroactive-%C3%AE-crystalline-phase-inclusion-and-photoluminescence-response-of-heat-controlled-spin-coated-pvdf-tio2-free-standing-nanocomposite-film-for-nanogenerator-and-active-nanosensor
#8
Md Mehebub Alam, Ayesha Sultana, Debabrata Sarkar, Dipankar Mandal
The electroactive β-phase is most desirable due to its highest piezo-, pyro- and ferro-electric properties in poly(vinylidene fluoride) (PVDF). Induction of β-phase is successfully accomplished in titanium dioxide (TiO2) nanoparticles (NPs) doped spin coated PVDF nanocomposite (PNC) films. The optimized yields of β-phase and homogeneous ultra-smooth free standing PNC film is utilized in mechanical energy harvesting application by fabricating a nanogenerator (NG) where the typical electrical poling step is not undertaken...
June 22, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28636883/the-effects-of-monocular-training-on-binocular-functions-in-anisometropic-amblyopia
#9
Wuli Jia, Fangfang Lan, Zhao Xin, Zhong-Lin Lu, Chang-Bing Huang, Wuxiao Zhao, Min Li
PURPOSE: It's been shown that intensive monocular perceptual learning can improve visual acuity, contrast sensitivity, and vernier acuity in the amblyopic eye in adults with amblyopia. It is however not clear how much monocular training can enhance binocular visual functions. In the current study, we aimed to evaluate effects of monocular training on a variety of binocular functions. METHODS: Nineteen anisometropic amblyopes (18.5±1.26 yrs) were trained in a grating contrast detection task near each individual's cutoff spatial frequency for 6 to 10 days (630 trials/day)...
June 18, 2017: Vision Research
https://www.readbyqxmd.com/read/28636680/unifying-the-microscopic-picture-of-his-containing-turns-from-gas-phase-model-peptides-to-crystallized-proteins
#10
Woon Yong Sohn, Sana Habka, Eric Gloaguen, Michel Mons
The presence in crystallized proteins of a local anchoring between the side chain of a His residue, located in the central position of a γ- or β-turn, and its local main chain environment, was assessed by the comparison of protein structures with relevant isolated model peptides. Gas phase laser spectroscopy, combined with relevant quantum chemistry methods, was used to characterize the γ- and β-turn structures in these model peptides. A conformer-selective NH stretch infrared study provided evidence for the formation in vacuo of two types of short-range H-bonded motifs, labelled ε-6(δ) and δ-(δ)7/π(H), bridging the His side chain (in its gauche+ rotamer) to the neighbouring NH(i) and CO(i) sites of the backbone; each side chain-backbone motif was found to be specific of the tautomer (ε or δ) adopted by the His side chain in its neutral form...
June 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28636566/detection-of-muscle-gap-by-l-bia-in-muscle-injuries-clinical-prognosis
#11
L Nescolarde, J Yanguas, J Terricabras, H Lukaski, X Alomar, J Rosell-Ferrer, G Rodas
Sport-related muscle injury classifications are based basically on imaging criteria such as ultrasound (US) and magnetic resonance imaging (MRI) without consensus because of a lack of clinical prognostics for return-to-play (RTP), which is conditioned upon the severity of the injury, and this in turn with the muscle gap (muscular fibers retraction). Recently, Futbol Club Barcelona's medical department proposed a new muscle injury classification in which muscle gap plays an important role, with the drawback that it is not always possible to identify by MRI...
June 21, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28636538/phase-i-dose-escalation-study-of-the-c-met-tyrosine-kinase-inhibitor-sar125844-in-asian-patients-with-advanced-solid-tumors-including-patients-with-met-amplified-gastric-cancer
#12
Kohei Shitara, Tae Min Kim, Tomoya Yokota, Masahiro Goto, Taroh Satoh, Jin-Hee Ahn, Hyo Song Kim, Sylvie Assadourian, Corinne Gomez, Marzia Harnois, Satoshi Hamauchi, Toshihiro Kudo, Toshihido Doi, Yung-Jue Bang
SAR125844 is a potent and selective inhibitor of the c-Met kinase receptor. This was an open-label, phase I, multicenter, dose-escalation, and dose-expansion trial of SAR125844 in Asian patients with solid tumors, a subgroup of whom had gastric cancer and MET amplification (NCT01657214). SAR125844 was administered by intravenous infusion (260-570 mg/m2) on days 1, 8, 15, and 22 of each 28-day cycle. Objectives were to determine the maximum tolerated dose (MTD) and to evaluate SAR125844 safety and pharmacokinetic profile...
June 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28636310/sensing-mechanisms-in-the-redox-regulated-2fe-2s-cluster-containing-bacterial-transcriptional-factor-soxr
#13
Kazuo Kobayashi
Bacteria possess molecular biosensors that enable responses to a variety of stressful conditions, including oxidative stress, toxic compounds, and interactions with other organisms, through elaborately coordinated regulation of gene expression. In Escherichia coli and related bacteria, the transcription factor SoxR functions as a sensor of oxidative stress and nitric oxide (NO). SoxR protein contains a [2Fe-2S] cluster essential for its transcription-enhancing activity, which is regulated by redox changes in the [2Fe-2S] cluster...
June 21, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28636208/a-phase-i-trial-of-prn1008-a-novel-reversible-covalent-inhibitor-of-bruton-s-tyrosine-kinase-in-healthy-volunteers
#14
Patrick F Smith, Janakan Krishnarajah, Philip A Nunn, Ron J Hill, Dane Karr, D Tam, Mohammad Masjedizadeh, Jens O Funk, Steve G Gourlay
AIM: To evaluate the safety, tolerability, and PK/PD of PRN1008, a novel BTK inhibitor, in healthy volunteers, and thus determine the dose range for future clinical studies. METHODS: This was a two-part randomized, placebo controlled study in healthy volunteers using a liquid formulation. Part I was a single ascending dose design with dose levels of 50 to 1200 mg (n=6 active, 2 placebo per cohort); Part II was a multiple ascending dose design, with dose regimens ranging from 300 mg to 900 mg daily, either qd or bd for 10 days...
June 21, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28636046/lead-ii-soaps-crystal-structures-polymorphism-and-solid-and-liquid-mesophases
#15
F J Martínez-Casado, M Ramos-Riesco, J A Rodríguez-Cheda, M I Redondo-Yélamos, L Garrido, A Fernández-Martínez, J García-Barriocanal, I da Silva, M Durán-Olivencia, A Poulain
The long-chain members of the lead(ii) alkanoate series or soaps, from octanoate to octadecanoate, have been thoroughly characterized by means of XRD, PDF analysis, DSC, FTIR, ssNMR and other techniques, in all their phases and mesophases. The crystal structures at room temperature of all of the members of the series are now solved, showing the existence of two polymorphic forms in the room temperature crystal phase, different to short and long-chain members. Only nonanoate and decanoate present both forms, and this polymorphism is proven to be monotropic...
June 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28635534/exploring-premenstrual-dysphoric-disorder-pmdd-in-the-work-context-a-qualitative-study
#16
Claire Hardy, Jenna Hardie
This study aims to explore women's experience of premenstrual dysphoric disorder (PMDD) in the workplace, and identify if organizations can do anything to help. Analysis of 15 semi-structured interviews, using an inductive thematic analysis approach, revealed the most common symptoms women experience at work include difficulty in concentrating, self-doubt, paranoia, fatigue, tearfulness, a heightened sensitivity to the environment and people, outbursts, and finding social interaction particularly difficult during this premenstrual "episode" phase...
February 21, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28634761/unveiling-the-compositional-variety-of-cardiolipins-in-rhodobacter-sphaeroides-by-liquid-chromatography-with-electrospray-ionization-and-multistage-collision-induced-dissociation-mass-spectrometry
#17
Sara Granafei, Ilario Losito, Massimo Trotta, Angela Agostiano, Francesco Palmisano, Tommaso R I Cataldi
Cardiolipins (CL) contained in the lipid extracts of the photosynthetic bacterium Rhodobacter sphaeroides (strain R26) were systematically characterized by reversed-phase liquid chromatography coupled to electrospray ionization mass spectrometry, performed in single (MS), tandem (MS/MS) and sequential (MS(3)) modes using a linear ion trap mass spectrometer. The total number of carbon atoms and C=C bonds of each CL and, subsequently, those related to each of the constituting phosphatidic acid (PA) units, along with the location of the latter on the central glycerol backbone, were inferred from MS and MS/MS data, respectively...
June 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28634654/improvement-in-latent-variable-indirect-response-modeling-of-multiple-categorical-clinical-endpoints-application-to-modeling-of-guselkumab-treatment-effects-in-psoriatic-patients
#18
Chuanpu Hu, Bruce Randazzo, Amarnath Sharma, Honghui Zhou
Exposure-response modeling plays an important role in optimizing dose and dosing regimens during clinical drug development. The modeling of multiple endpoints is made possible in part by recent progress in latent variable indirect response (IDR) modeling for ordered categorical endpoints. This manuscript aims to investigate the level of improvement achievable by jointly modeling two such endpoints in the latent variable IDR modeling framework through the sharing of model parameters. This is illustrated with an application to the exposure-response of guselkumab, a human IgG1 monoclonal antibody in clinical development that blocks IL-23...
June 20, 2017: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/28634446/are-distal-and-proximal-visual-cues-equally-important-during-spatial-learning-in-mice-a-pilot-study-of-overshadowing-in-the-spatial-domain
#19
Marie Hébert, Jan Bulla, Denis Vivien, Véronique Agin
Animals use distal and proximal visual cues to accurately navigate in their environment, with the possibility of the occurrence of associative mechanisms such as cue competition as previously reported in honey-bees, rats, birds and humans. In this pilot study, we investigated one of the most common forms of cue competition, namely the overshadowing effect, between visual landmarks during spatial learning in mice. To this end, C57BL/6J × Sv129 mice were given a two-trial place recognition task in a T-maze, based on a novelty free-choice exploration paradigm previously developed to study spatial memory in rodents...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28634436/dual-coding-theory-explains-biphasic-collective-computation-in-neural-decision-making
#20
Bryan C Daniels, Jessica C Flack, David C Krakauer
A central question in cognitive neuroscience is how unitary, coherent decisions at the whole organism level can arise from the distributed behavior of a large population of neurons with only partially overlapping information. We address this issue by studying neural spiking behavior recorded from a multielectrode array with 169 channels during a visual motion direction discrimination task. It is well known that in this task there are two distinct phases in neural spiking behavior. Here we show Phase I is a distributed or incompressible phase in which uncertainty about the decision is substantially reduced by pooling information from many cells...
2017: Frontiers in Neuroscience
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